545380-34-5 | QNZ

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$48.00	$34.00
5mg	95%	in stock	$116.00	$81.00
10mg	95%	in stock	$191.00	$134.00
25mg	95%	in stock	$340.00	$238.00
50mg	95%	in stock	$454.00	$318.00
100mg	95%	in stock	$555.00	$388.00
250mg	95%	in stock	$883.00	$618.00
1g	95%	in stock	$2,135.00	$1,494.00

Description

• Catalog Number: AG18985
• Chemical Name: QNZ
• CAS Number: 545380-34-5
• Molecular Formula: C22H20N4O
• Molecular Weight: 356.4204
• MDL Number: MFCD06411436
• SMILES: Nc1ccc2c(c1)c(NCCc1ccc(cc1)Oc1ccccc1)ncn2

Computed Properties

• Complexity: 434
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 4.7

Literature

• Diallyl trisulfide suppresses doxorubicin-induced cardiomyocyte apoptosis by inhibiting MAPK/NF-κB signaling through attenuation of ROS generation.

  Environmental toxicology 20180101

• Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.

  Leukemia 20160101

• CPT-11 activates NLRP3 inflammasome through JNK and NF-κB signalings.

  Toxicology and applied pharmacology 20151201

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Infection of polarized airway epithelial cells by normal and small-colony variant strains of Staphylococcus aureus is increased in cells with abnormal cystic fibrosis transmembrane conductance regulator function and is influenced by NF-κB.

  Infection and immunity 20110901

• Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.

  Chemistry & biology 20110624

• Axotomy induces axonogenesis in hippocampal neurons through STAT3.

  Cell death & disease 20110601

• Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production.

  PloS one 20110101

• JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.

  Journal of biomedical science 20110101

• Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.

  PloS one 20110101

• SERCA2 regulates non-CF and CF airway epithelial cell response to ozone.

  PloS one 20110101

• Signaling pathways involved in LPS induced TNFalpha production in human adipocytes.

  Journal of inflammation (London, England) 20100101

• Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.

  PloS one 20100101

• High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.

  Genome medicine 20100101

• Reactive oxygen species enhance TLR10 expression in the human monocytic cell line THP-1.

  International journal of molecular sciences 20100101

• Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock.

  Journal of cellular and molecular medicine 20090801

• Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.

  Bioorganic & medicinal chemistry letters 20090315

• Laminin activates NF-kappaB in Schwann cells to enhance neurite outgrowth.

  Neuroscience letters 20080704

• Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis.

  BMC immunology 20080101

• Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells.

  The Journal of biological chemistry 20060505

• A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives.

  Bioorganic & medicinal chemistry 20030901

• Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation.

  Bioorganic & medicinal chemistry 20030206

• Signal transduction through NF-kappa B.

  Immunology today 19980201

• The role of nuclear factor-kappa B in cytokine gene regulation.

  American journal of respiratory cell and molecular biology 19970701

• NF-kappa B: ten years after.

  Cell 19961004

• Function and activation of NF-kappa B in the immune system.

  Annual review of immunology 19940101

• Cytokines in clinical and experimental transplantation.

  Mediators of inflammation 19940101