546-43-0 | Alantolactone

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$9.00	$6.00
25mg	98%	in stock	$32.00	$22.00
250mg	95%	in stock	$267.00	$187.00
1g	95%	in stock	$605.00	$423.00

Description

• Catalog Number: AI52250
• Chemical Name: Alantolactone
• CAS Number: 546-43-0
• Molecular Formula: C15H20O2
• Molecular Weight: 232.3181
• MDL Number: MFCD00274568
• SMILES: C[C@H]1CCC[C@]2(C1=C[C@H]1[C@@H](C2)OC(=O)C1=C)C
• NSC Number: 93131

Computed Properties

• Complexity: 421
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 3.7

Literature

• Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression.

  Toxicology letters 20140130

• Alantolactone induces activation of apoptosis in human hepatoma cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction.

  IUBMB life 20120901

• Antistaphylococcal activity of Inula helenium L. root essential oil: eudesmane sesquiterpene lactones induce cell membrane damage.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20120601

• The tibetan uterotonic zhi byed 11: mechanisms of action, efficacy, and historical use for postpartum hemorrhage.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharides.

  Arthritis and rheumatism 20120101

• Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells.

  International journal of biological sciences 20120101

• Evaluation of protective effect of Butea monosperma (lam.) Taub in experimental hepatotoxicity in rats.

  Journal of pharmacology & pharmacotherapeutics 20120101

• Ultrasound-assisted extraction of total flavonoids from Inula helenium.

  Pharmacognosy magazine 20120101

• Sesquiterpene lactones from Inula falconeri, a plant endemic to the Himalayas, as potential anti-inflammatory agents.

  European journal of medicinal chemistry 20111101

• Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway.

  Journal of biomolecular screening 20110601

• Screening for Compositae sensitization with pure allergens: implications of molecular structure, strength of reaction, and time of testing.

  Contact dermatitis 20110201

• Potent cytotoxic effects of Calomeria amaranthoides on ovarian cancers.

  Journal of experimental & clinical cancer research : CR 20110101

• Modeling natural anti-inflammatory compounds by molecular topology.

  International journal of molecular sciences 20110101

• Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa.

  Toxicology in vitro : an international journal published in association with BIBRA 20100901

• Structure-activity relationship studies on derivatives of eudesmanolides from Inula helenium as toxicants against Aedes aegypti larvae and adults.

  Chemistry & biodiversity 20100701

• Protection by Chrysanthemum zawadskii extract from liver damage of mice caused by carbon tetrachloride is maybe mediated by modulation of QR activity.

  Nutrition research and practice 20100401

• HPLC determination and NMR structural elucidation of sesquiterpene lactones in Inula helenium.

  Journal of pharmaceutical and biomedical analysis 20100311

• Ultrasound-assisted extraction of alantolactone and isoalantolactone from Inula helenium roots.

  Pharmacognosy magazine 20100101

• Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats.

  Pharmacognosy research 20100101

• Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes.

  Journal of medicinal food 20091001

• Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium.

  Phytotherapy research : PTR 20081101

• A rapid identification of Radix inulae and its active component alantolactone in the Tibetan medicine Manuxitang.

  Bioscience trends 20080401

• Microbial transformation of alantolactone by Mucor polymorphosporus.

  Journal of Asian natural products research 20080101

• Induction of detoxifying enzyme by sesquiterpenes present in Inula helenium.

  Journal of medicinal food 20070901

• Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.

  Bioorganic & medicinal chemistry letters 20061101

• Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system.

  Bioorganic & medicinal chemistry 20060101

• Simultaneous quantification of eudesmanolides and thymol derivatives from tissues of Inula helenium and I. royleana by reversed-phase high-performance liquid chromatography.

  Phytochemical analysis : PCA 20060101

• Separation and determination of two sesquiterpene lactones in Radix inulae and Liuwei Anxian San by microemulsion electrokinetic chromatography.

  Biomedical chromatography : BMC 20041201

• Erythema multiforme due to contact with weeds: a recurrence after patch testing.

  Contact dermatitis 20030101

• Antifungal highly oxygenated guaianolides and other constituents from Ajania fruticulosa.

  Phytochemistry 20011201

• Antimycobacterial plant terpenoids.

  Planta medica 20011101

• Sensitization and cross-reaction patterns in Danish Compositae-allergic patients.

  Contact dermatitis 20011001

• Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis.

  Planta medica 20010801

• Patch test sensitization to Compositae mix, sesquiterpene-lactone mix, Compositae extracts, laurel leaf, Chlorophorin, Mansonone A, and dimethoxydalbergione.

  American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20010301

• Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.

  Bioorganic & medicinal chemistry letters 20010212

• Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.

  Planta medica 19990501

• A murine in vitro model of allergic contact dermatitis to sesquiterpene alpha-methylene-gamma-butyrolactones.

  Archives of dermatological research 19920101