565460-15-3 | Urb602

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$47.00	$33.00
10mg	≥98%	in stock	$85.00	$60.00
50mg	≥98%	in stock	$353.00	$247.00
100mg	≥98%	in stock	$614.00	$430.00

Description

• Catalog Number: AB72348
• Chemical Name: Urb602
• CAS Number: 565460-15-3
• Molecular Formula: C19H21NO2
• Molecular Weight: 295.3755
• MDL Number: MFCD08457914
• SMILES: O=C(Nc1cccc(c1)c1ccccc1)OC1CCCCC1

Computed Properties

• Complexity: 345
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 22
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 4.9

Literature

• Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats.

  Pediatric research 20121001

• Expression and function of monoacylglycerol lipase in mouse β-cells and human islets of Langerhans.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors.

  Bioorganic & medicinal chemistry letters 20111115

• Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20111012

• Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain.

  British journal of pharmacology 20110801

• Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ.

  British journal of pharmacology 20110801

• Modulation of anticonvulsant effects of cannabinoid compounds by GABA-A receptor agonist in acute pentylenetetrazole model of seizure in rat.

  Neurochemical research 20110801

• Memory encoding in hippocampal ensembles is negatively influenced by cannabinoid CB1 receptors.

  Behavioural pharmacology 20110801

• Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults.

  Neuroscience 20110331

• Behavioral sequelae following acute diisopropylfluorophosphate intoxication in rats: comparative effects of atropine and cannabinomimetics.

  Neurotoxicology and teratology 20100101

• Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.

  Journal of medicinal chemistry 20091210

• Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons.

  Molecular pharmacology 20091201

• Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.

  Journal of medicinal chemistry 20091126

• Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound palmitoylethanolamide.

  European journal of pharmacology 20090521

• Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.

  Nature chemical biology 20090101

• Distribution and function of monoacylglycerol lipase in the gastrointestinal tract.

  American journal of physiology. Gastrointestinal and liver physiology 20081201

• Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake?

  Pharmacological research 20080701

• Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity.

  British journal of pharmacology 20080401

• Microglia produce and hydrolyze palmitoylethanolamide.

  Neuropharmacology 20080101

• Fatty pain cures.

  Chemistry & biology 20071201

• URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.

  Chemistry & biology 20071201

• The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation.

  British journal of pharmacology 20071101

• The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors.

  British journal of pharmacology 20070301

• Inhibitors of monoacylglycerol lipase as novel analgesics.

  British journal of pharmacology 20070301

• Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro.

  British journal of pharmacology 20070101

• URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain.

  Chemistry & biology 20060801

• Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia.

  Neuroscience letters 20060424

• An endocannabinoid mechanism for stress-induced analgesia.

  Nature 20050623

• Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

  Journal of medicinal chemistry 20030605