568-73-0 | Tanshinone i

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%	in stock	$74.00	$52.00
100mg	95%	in stock	$76.00	$53.00
250mg	95%	in stock	$128.00	$90.00
1g	95%	in stock	$342.00	$239.00

Description

• Catalog Number: AI52729
• Chemical Name: Tanshinone i
• CAS Number: 568-73-0
• Molecular Formula: C18H12O3
• Molecular Weight: 276.28607999999997
• MDL Number: MFCD00210563
• SMILES: Cc1coc2-c3c(C(=O)C(=O)c12)c1cccc(c1cc3)C

Computed Properties

• Complexity: 471
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 3
• XLogP3: 3.7

Literature

• Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice.

  Toxicology and applied pharmacology 20180401

• Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B.

  Chemico-biological interactions 20171225

• Tanshinone IIA ameliorated endothelial dysfunction in rats with chronic intermittent hypoxia.

  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20170101

• Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.

  The New phytologist 20160401

• Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines.

  Chemical research in toxicology 20150817

• Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.

  Chemico-biological interactions 20150325

• Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia.

  Chinese journal of integrative medicine 20121101

• Tanshinone IIA in acute promyelocytic leukemia.

  The American journal of the medical sciences 20121001

• PEG and ABA trigger methyl jasmonate accumulation to induce the MEP pathway and increase tanshinone production in Salvia miltiorrhiza hairy roots.

  Physiologia plantarum 20121001

• Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.

  Bioorganic & medicinal chemistry 20121001

• Release behavior of tanshinone IIA sustained-release pellets based on crack formation theory.

  Journal of pharmaceutical sciences 20120801

• Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation.

  Translational research : the journal of laboratory and clinical medicine 20120801

• Salvia miltiorrhiza causes tonic contraction in rat ileum through Ca²⁺-calmodulin pathway.

  Journal of ethnopharmacology 20120801

• Design, synthesis and vasodilative activity of tanshinone IIA derivatives.

  Bioorganic & medicinal chemistry letters 20120801

• [Clarithromycin combined with tanshinone for rhinosinusal and laryngeal radiation injury in patients with nasopharyngeal carcinoma after radiotherapy].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120801

• The protective effects of tanshinone IIA on β-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron.

  Brain research bulletin 20120701

• Rational design of core-shell molecularly imprinted polymer based on computational simulation and Doehlert experimental optimization: application to the separation of tanshinone IIA from Salvia miltiorrhiza Bunge.

  Analytical and bioanalytical chemistry 20120701

• [Effects of tanshinone IIA on Wnt/beta-catenin signaling pathway of high glucose induced renal tubular epithelial cell transdifferentiation].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120701

• Tanshinones from Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling.

  Pharmaceutical research 20120601

• Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway.

  Molecular biology reports 20120601

• Tanshinone IIA prevents uric acid nephropathy in rats through NF-κB inhibition.

  Planta medica 20120601

• Tanshinone IIA prevents doxorubicin-induced cardiomyocyte apoptosis through Akt-dependent pathway.

  International journal of cardiology 20120531

• Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120515

• Roles of reactive oxygen species in methyl jasmonate and nitric oxide-induced tanshinone production in Salvia miltiorrhiza hairy roots.

  Plant cell reports 20120501

• Tanshinone IIA inhibits BT-20 human breast cancer cell proliferation through increasing caspase 12, GADD153 and phospho-p38 protein expression.

  International journal of molecular medicine 20120501

• Tanshinones increase fibrinolysis through inhibition of plasminogen activator inhibitor-1.

  CNS neuroscience & therapeutics 20120501

• [Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120501

• [Study on solid dispersion of binary vector of tanshinone II A].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

• Tanshinone IIA inhibits human breast cancer MDA-MB-231 cells by decreasing LC3-II, Erb-B2 and NF-κBp65.

  Molecular medicine reports 20120401

• Tanshinone IIA-loaded reconstituted high density lipoproteins: Atherosclerotic plaque targeting mechanism in a foam cell model and pharmacokinetics in rabbits.

  Die Pharmazie 20120401

• Modeling gradient elution in countercurrent chromatography: efficient separation of tanshinones from Salvia miltiorrhiza Bunge.

  Journal of separation science 20120401

• Development of intravenous lipid emulsion of tanshinone IIA and evaluation of its anti-hepatoma activity in vitro.

  International journal of pharmaceutics 20120315

• Production of salvianolic acid B in roots of Salvia miltiorrhiza (Danshen) during the post-harvest drying process.

  Molecules (Basel, Switzerland) 20120227

• Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120215

• Protective effect of tanshinone IIA on rat kidneys during hypothermic preservation.

  Molecular medicine reports 20120201

• Tanshinone IIA induces growth inhibition and apoptosis in gastric cancer in vitro and in vivo.

  Oncology reports 20120201

• Novel Tanshinone II A ternary solid dispersion pellets prepared by a single-step technique: in vitro and in vivo evaluation.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120201

• Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro.

  Anti-cancer drugs 20120201

• Antiandrogenic, maspin induction, and antiprostate cancer activities of tanshinone IIA and its novel derivatives with modification in ring A.

  Journal of medicinal chemistry 20120126

• Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120115

• Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress.

  European journal of pharmacology 20120115

• Cardiovascular actions and therapeutic potential of tanshinone IIA.

  Atherosclerosis 20120101

• Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells.

  Journal of natural medicines 20120101

• Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo.

  Molecular medicine reports 20120101

• Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells.

  Clinical and experimental pharmacology & physiology 20120101

• Protection of Tanshinone IIA to human peritoneal mesothelial cells (HPMC) through delaying cellular senescence induced by high glucose.

  Renal failure 20120101

• Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion.

  Frontiers in bioscience (Elite edition) 20120101

• Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling.

  BMC complementary and alternative medicine 20120101

• Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats.

  Biological & pharmaceutical bulletin 20120101

• Metabolic profiles and cDNA-AFLP analysis of Salvia miltiorrhiza and Salvia castanea Diel f. tomentosa Stib.

  PloS one 20120101

• Analysis of Danshen and twelve related Salvia species.

  Natural product communications 20120101

• Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function.

  PloS one 20120101

• Tanshinone IIA attenuates the inflammatory response and apoptosis after traumatic injury of the spinal cord in adult rats.

  PloS one 20120101

• Tanshinone IIA stimulates erythrocyte phosphatidylserine exposure.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.

  Bioorganic & medicinal chemistry letters 20111215

• Tanshinone IIa alleviates the biochemical changes associated with hypoxic ischemic brain damage in a rat model.

  Phytotherapy research : PTR 20111201

• [Correlation between expression level of functional genes and tanshinones' accumulation in Salvia miltiorrhiza from different areas].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201

• Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells.

  Cancer letters 20111128

• Tanshinone IIA-induced attenuation of lung injury in endotoxemic mice is associated with reduction of hypoxia-inducible factor 1α expression.

  American journal of respiratory cell and molecular biology 20111101

• Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20111101

• Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet.

  Archives of biochemistry and biophysics 20111101

• [Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111101

• Structure and remodeling behavior of drug-loaded high density lipoproteins and their atherosclerotic plaque targeting mechanism in foam cell model.

  International journal of pharmaceutics 20111031

• [Investigation on the molecular structures and electronic absorption spectra of Tanshinone II A and Tanshinone II A -Cu(II) complex].

  Guang pu xue yu guang pu fen xi = Guang pu 20111001

• Cytotoxic effect and apoptotic mechanism of tanshinone A, a novel tanshinone derivative, on human erythroleukemic K562 cells.

  European journal of pharmacology 20110930

• Development of a strategy and process parameters for a green process in counter-current chromatography: purification of tanshinone IIA and cryptotanshinone from Salvia miltiorrhiza Bunge as a case study.

  Journal of chromatography. A 20110909

• Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.

  International journal of cancer 20110901

• Effects of tanshinone IIA, a major component of Salvia miltiorrhiza, on platelet aggregation in healthy newborn piglets.

  Journal of ethnopharmacology 20110901

• [Study on the pharmacokinetics of tashinone II(A) -loaded polylactic acid nanoparticles in rabbit].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110901

• In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.

  Bioorganic & medicinal chemistry 20110815

• Preparation, characterization and cytotoxicity evaluation of tanshinone IIA nanoemulsions.

  Journal of biomedical nanotechnology 20110801

• [Apoptosis inducing effect of tanshinone II(A) on human nasopharyngeal carcinoma CNE cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

• Ultrasonication-assisted extraction and preconcentration of medicinal products from herb by ionic liquids.

  Talanta 20110715

• Extraction and preparative purification of tanshinones from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110701

• [Effect of tanshinone II A on TLR4 and TNF-α of endothelial cells induced by LPS].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20110701

• Tanshinone IIA prevents cardiac remodeling through attenuating NAD (P)H oxidase-derived reactive oxygen species production in hypertensive rats.

  Die Pharmazie 20110701

• Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship.

  Fitoterapia 20110601

• Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways.

  Journal of ethnopharmacology 20110601

• QSAR study for cytotoxicity of diterpenoid tanshinones.

  Interdisciplinary sciences, computational life sciences 20110601

• Preparation and physicochemical characterizations of tanshinone IIA solid dispersion.

  Archives of pharmacal research 20110601

• Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures.

  Metabolic engineering 20110501

• Nano-LC-MS/MS based proteomics of hepatocellular carcinoma cells compared to Chang liver cells and tanshinone IIA induction.

  Molecular bioSystems 20110501

• In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.

  Environmental toxicology and pharmacology 20110501

• [Effects of elicitors on accumulation of phenolic acids and tanshinones in Salvia miltiorrhiza hairy root].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

• [Effects of phytohormones on hairy root growth and tanshinone biosynthesis of Salvia miltiorrhiza].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

• Tanshinone IIA ameliorates seawater exposure-induced lung injury by inhibiting aquaporins (AQP) 1 and AQP5 expression in lung.

  Respiratory physiology & neurobiology 20110430

• Tanshinone IIA increases recruitment of bone marrow mesenchymal stem cells to infarct region via up-regulating stromal cell-derived factor-1/CXC chemokine receptor 4 axis in a myocardial ischemia model.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110415

• Candidate genes involved in tanshinone biosynthesis in hairy roots of Salvia miltiorrhiza revealed by cDNA microarray.

  Molecular biology reports 20110401

• Modeling of tanshinone synthesis and phase distribution under the combined effect of elicitation and in situ adsorption in Salvia miltiorrhiza hairy root cultures.

  Biotechnology letters 20110401

• Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line.

  Toxicology and applied pharmacology 20110401

• Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways.

  Therapeutic advances in cardiovascular disease 20110401

• Tanshinone IIA suppresses lung injury and apoptosis, and modulates protein kinase B and extracellular signal-regulated protein kinase pathways in rats challenged with seawater exposure.

  Clinical and experimental pharmacology & physiology 20110401

• Plant density-dependent variations in bioactive markers and root yield in Australian-grown Salvia miltiorrhiza Bunge.

  Chemistry & biodiversity 20110401

• Metabolomic strategy to study therapeutic and synergistic effects of tanshinone IIA, salvianolic acid B and ginsenoside Rb1 in myocardial ischemia rats.

  Journal of ethnopharmacology 20110308

• Tanshinone IIA attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide.

  Journal of ethnopharmacology 20110308

• Regulation of adhesion molecules expression in TNF-α-stimulated brain microvascular endothelial cells by tanshinone IIA: involvement of NF-κB and ROS generation.

  Phytotherapy research : PTR 20110301

• Tanshinone IIA acts via p38 MAPK to induce apoptosis and the down-regulation of ERCC1 and lung-resistance protein in cisplatin-resistant ovarian cancer cells.

  Oncology reports 20110301

• Molecular imprinting in ionic liquid-modified porous polymer for recognitive separation of three tanshinones from Salvia miltiorrhiza Bunge.

  Analytical and bioanalytical chemistry 20110301

• Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.

  Natural product reports 20110301

• Direct vasorelaxation by a novel phytoestrogen tanshinone IIA is mediated by nongenomic action of estrogen receptor through endothelial nitric oxide synthase activation and calcium mobilization.

  Journal of cardiovascular pharmacology 20110301

• [Effects of soil water content on seedlings growth and active ingredients of Salvia miltiorrhiza].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110201

• [Growth inhibition of tanshinones on SPC-A-1 cell line and their structure-activity relationship].

  Zhongguo fei ai za zhi = Chinese journal of lung cancer 20110120

• Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation.

  Journal of plant physiology 20110115

• Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression.

  European journal of pharmacology 20110110

• Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy.

  Cardiovascular diabetology 20110101

• [Effect of sulfonic tanshinone sodium injection on the expression and activity of aquaporin-5 of human alveolar epithelial cells after seawater exposure].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20110101

• Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Tanshinone IIA attenuates peritoneal fibrosis through inhibition of fibrogenic growth factors expression in peritoneum in a peritoneal dialysis rat model.

  Renal failure 20110101

• Tanshinone IIA inhibits angiotensin II-induced cell proliferation in rat cardiac fibroblasts.

  The American journal of Chinese medicine 20110101

• Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway.

  International journal of biological sciences 20110101

• Tanshinone IIA attenuates seawater aspiration-induced lung injury by inhibiting macrophage migration inhibitory factor.

  Biological & pharmaceutical bulletin 20110101

• [The quality of Salvia miltforthiza from Beijing suburbs with different growing modes].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110101

• Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20101215

• The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201

• The neuroprotective effects of tanshinone IIA on β-amyloid-induced toxicity in rat cortical neurons.

  Neuropharmacology 20101201

• Tanshinone IIA protects the human blood-brain barrier model from leukocyte-associated hypoxia-reoxygenation injury.

  European journal of pharmacology 20101201

• The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts.

  Arthritis and rheumatism 20101201

• Activation of CYP3A-mediated testosterone 6β-hydroxylation by tanshinone IIA and midazolam 1-hydroxylation by cryptotanshinone in human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20101201

• Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease.

  Phytotherapy research : PTR 20101201

• Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes.

  Acta pharmacologica Sinica 20101201

• [Inhibitory effect of tanshinones on proliferation of K562 cell line and its structure-activity relationship].

  Zhongguo shi yan xue ye xue za zhi 20101201

• Study of anti-myocardial cell oxidative stress action and effect of tanshinone IIA on prohibitin expression.

  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20101201

• Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic-mass spectrometry and the application to pharmacokinetics in rats.

  Journal of pharmaceutical and biomedical analysis 20101102

• Tanshinone IIA enhances BMP-2-stimulated commitment of C2C12 cells into osteoblasts via p38 activation.

  Amino acids 20101101

• A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway.

  Cancer letters 20101101

• Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro.

  Annals of hematology 20101101

• C/EBPβ and CHOP participate in tanshinone IIA-induced differentiation and apoptosis of acute promyelocytic leukemia cells in vitro.

  International journal of hematology 20101101

• [A successful case of tanshinone II A treatment for relapsed acute promyelocytic leukemia after maintainance therapy of all-trans retinoic acid and arsenic trioxide].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20101101

• [Absorption mechanism of tanshinone II A, cryptotanshinone, tanshinone I and tanshinones extract in rat small intestine in vivo].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

• [Effect of tanshitone on prevention and treatment of retinoic acid induced osteoporosis in mice].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

• [Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].

  Yao xue xue bao = Acta pharmaceutica Sinica 20101101

• Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice.

  Journal of ethnopharmacology 20101028

• [Preparation and in vitro evaluation of tanshinone IIA pulsatile release pellets].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20101018

• Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100901

• Tanshinone IIA inhibits Hep-J5 cells by increasing calreticulin, caspase 12 and GADD153 protein expression.

  International journal of molecular medicine 20100901

• Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures.

  Applied microbiology and biotechnology 20100901

• Preparation and evaluation of silica-based ionic liquid-modified stationary phase for HPLC.

  Journal of chromatographic science 20100901

• [Effect of tanshinone IIA pretreatment on IL-1β and RelA mRNA expression in rats with focal cerebral ischemia].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100901

• [Effect of Tanshinone IIA on phosphorylated NMDA receptor 1 expression and intracellular free calcium concentration in neonatal SD rats with hypoxic ischemic brain damage].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20100901

• Tanshinone IIA modulates pulmonary vascular response to agonist and hypoxia primarily via inhibiting Ca2+ influx and release in normal and hypoxic pulmonary hypertension rats.

  European journal of pharmacology 20100825

• Synthesis and vasodilative activity of tanshinone IIA derivatives.

  Bioorganic & medicinal chemistry letters 20100815

• [Effect of tanshinone IIA on the change of calcium current induced by beta-amyloid protein 25-35 in neurons of nucleus basalis of Meynert].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20100801

• [Data distribution characteristics and deviation of tanshinone IIA content in Radix Salviae Miltiorrhizae].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801

• Regioselective glucuronidation of tanshinone iia after quinone reduction: identification of human UDP-glucuronosyltransferases, species differences, and interaction potential.

  Drug metabolism and disposition: the biological fate of chemicals 20100701

• [Dissolution of tanshinone IIA from xianling gubao capsule].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100701

• [Neuroprotective effects of tanshinone II A on vascular dementia in rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100701

• Effects of biotic and abiotic elicitors on cell growth and tanshinone accumulation in Salvia miltiorrhiza cell cultures.

  Applied microbiology and biotechnology 20100601

• Nanostructured lipid carriers constituted from high-density lipoprotein components for delivery of a lipophilic cardiovascular drug.

  International journal of pharmaceutics 20100531

• The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke.

  Brain research bulletin 20100531

• Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.

  Journal of natural products 20100528

• Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway.

  Journal of ethnopharmacology 20100527

• Tanshinone IIA protects rat primary hepatocytes against carbon tetrachloride toxicity via inhibiting mitochondria permeability transition.

  Pharmaceutical biology 20100501

• [Effect of tanshinone II A on the transforming growth factor beta1/Smads signal pathway in rats with hypertensive myocardial hypertrophy].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100501

• [Self-microemulsifying drug delivery system increasing solubility and intestinal absorption in situ of tanshinones].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100501

• Structural elucidation of metabolites of tanshinone I and its analogue dihydrotanshinone I in rats by HPLC-ESI-MSn.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100415

• Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats.

  Diabetes, obesity & metabolism 20100401

• [Study on the chemical stability of tanshinone IIA].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100401

• [Transcriptome characterization for Salvia miltiorrhiza using 454 GS FLX].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100401

• Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia.

  Brain research 20100319

• Tanshinone IIA protects against immune-mediated liver injury through activation of T-cell subsets and regulation of cytokines.

  Immunopharmacology and immunotoxicology 20100301

• Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100301

• Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells.

  Proteomics 20100301

• Tanshinone IIA inhibits constitutive STAT3 activation, suppresses proliferation, and induces apoptosis in rat C6 glioma cells.

  Neuroscience letters 20100212

• Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential.

  International journal of molecular medicine 20100201

• Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage.

  Neuroscience bulletin 20100201

• Tanshinone II A induces apoptosis and S phase cell cycle arrest in activated rat hepatic stellate cells.

  Basic & clinical pharmacology & toxicology 20100101

• Direct purification of tanshinones from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography without presaturation of the two-phase solvent mixture.

  Journal of separation science 20100101

• [Apoptosis of NB4 cells induced by Tanshinone II A combined with arsenic trioxide].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100101

• [A study on the effect of Tanshinone II A against human breast cancer in vivo].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100101

• Down-regulation of telomerase activity and activation of caspase-3 are responsible for Tanshinone I-induced apoptosis in monocyte leukemia cells in vitro.

  International journal of molecular sciences 20100101

• Tanshinone IIA increases mRNA expression of efflux transporters in cultured human intestinal cell.

  The American journal of Chinese medicine 20100101

• Tanshinone IIA induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway.

  Biological & pharmaceutical bulletin 20100101

• Study of sodium tanshinone II A sulfonate tissue distribution in rat by liquid chromatography/tandem mass spectrometry.

  Arzneimittel-Forschung 20100101

• Tanshinone IIA inhibits miR-1 expression through p38 MAPK signal pathway in post-infarction rat cardiomyocytes.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Experimental study of the anti-cancer mechanism of tanshinone IIA against human breast cancer.

  International journal of molecular medicine 20091201

• Ionic liquid surfactant-mediated ultrasonic-assisted extraction coupled to HPLC: application to analysis of tanshinones in Salvia miltiorrhiza bunge.

  Journal of separation science 20091201

• Anti-inflammatory effects of tanshinone IIA on radiation-induced microglia BV-2 cells inflammatory response.

  Cancer biotherapy & radiopharmaceuticals 20091201

• A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.

  Organic letters 20091119

• Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.

  Cancer letters 20091118

• Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding.

  Biochemical pharmacology 20091115

• Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091101

• Nuclear matrix protein, prohibitin, was down-regulated and translocated from nucleus to cytoplasm during the differentiation of osteosarcoma MG-63 cells induced by ginsenoside Rg1, cinnamic acid, and tanshinone IIA (RCT).

  Journal of cellular biochemistry 20091101

• Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1.

  British journal of pharmacology 20091101

• Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells.

  Acta pharmacologica Sinica 20091101

• [Effect of tanshinone II on hepatic fibrosis in mice].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20091101

• Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway.

  British journal of pharmacology 20091001

• Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats.

  Chinese journal of integrative medicine 20091001

• Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels.

  European journal of pharmacology 20090901

• Characterization of tanshinones with quinone reductase induction activity from Radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20090901

• [Apoptosis of MR2 cells induced by Tanshinone II A combined with arsenic trioxide].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090901

• Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20090801

• The effect of tanshinone IIA upon the TGF-beta1/Smads signaling pathway in hypertrophic myocardium of hypertensive rats.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090801

• [A new identification and quautitation method for radix Salviae miltiorrhizae].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

• Metabolic profiles of three related Salvia species.

  Fitoterapia 20090701

• Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090701

• Tanshinone IIA selectively enhances hyperpolarization-activated cyclic nucleotide-modulated (HCN) channel instantaneous current.

  Journal of pharmacological sciences 20090701

• [Tanshinone IIA down-regulates the expression of MMP-12 and TF in RAW 264.7 cells].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090701

• HPLC profiles and biomarker contents of Australian-grown Salvia miltiorrhiza f. alba roots.

  Chemistry & biodiversity 20090701

• Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris.

  International journal of cardiology 20090626

• Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice.

  Phytotherapy research : PTR 20090501

• Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6.

  Xenobiotica; the fate of foreign compounds in biological systems 20090501

• Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats.

  Die Pharmazie 20090501

• Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20090401

• Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis.

  Oncology reports 20090401

• Tanshinone IIA reduces lethality and acute lung injury in LPS-treated mice by inhibition of PLA2 activity.

  European journal of pharmacology 20090401

• Seasonal variations in bioactive marker contents in Australian-grown Salvia miltiorrhiza roots.

  Chemistry & biodiversity 20090401

• Tanshinone IIA: a potent, natural anti-carcinogenic agent for the management of systemic malignancies.

  Chinese journal of integrative medicine 20090401

• Solid-phase extraction of tanshinones from Salvia Miltiorrhiza Bunge using ionic liquid-modified silica sorbents.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090315

• [Effect of Tanshinone II A on expression of EGF and EGFR in hepatocellular carcinoma cell line SMMC-7721].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20090301

• [A study on anticancer activity of tanshinone II A against human breast cancer].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090301

• [Influence of solid dispersion technique combination on dissolution of tanshinone IIA].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301

• Quercetin activates human Kv1.5 channels by a residue I502 in the S6 segment.

  Clinical and experimental pharmacology & physiology 20090201

• Protective effect of Tanshinone IIA on the early stage of experimental diabetic nephropathy.

  Biological & pharmaceutical bulletin 20090201

• Cultivar variations of Australian-grown Danshen (Salvia miltiorrhiza): bioactive markers and root yields.

  Chemistry & biodiversity 20090201

• [Effects of Tanshinone IIa on cytokines and platelets in immune vasculitis and its mechanism].

  Zhongguo shi yan xue ye xue za zhi 20090201

• [Effect of tanshinone II A on the calcineurin activity in proliferating vascular smooth muscle cells of rats].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090201

• The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS.

  The Journal of steroid biochemistry and molecular biology 20090201

• PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.

  Chemico-biological interactions 20090115

• Cloning and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza (Chinese sage) hairy roots.

  Biotechnology and applied biochemistry 20090101

• The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism.

  Endocrinology 20090101

• [Effect of tanshinone II A on NB4 cell induced procoagulant activity in human umbilical vein endothelial cells].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090101

• [AOTF-near infrared spectroscopy for determining tanshinone II A in returning extraction process of Salvia miltiorrhiza].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090101

• Genetic stability, active constituent, and pharmacoactivity of Salvia miltiorrhiza hairy roots and wild plant.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

• The effect of tanshinone IIA on renal and liver functions in ovine fetuses in utero.

  Drug and chemical toxicology 20090101

• The effect of tanshinone IIA on the cardiovascular system in ovine fetus in utero.

  The American journal of Chinese medicine 20090101

• Study on the intestinal absorption profiles of tanshinone IIA and its inclusion complex with cyclodextrin in rats.

  PDA journal of pharmaceutical science and technology 20090101

• Tanshinone II-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo.

  Tumori 20090101

• Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts.

  European journal of pharmacology 20081228

• Investigation of Danshen and related medicinal plants in China.

  Journal of ethnopharmacology 20081208

• Inhibition of microsomal triglyceride transfer protein expression and atherogenic risk factor apolipoprotein B100 secretion by tanshinone IIA in HepG2 cells.

  Phytotherapy research : PTR 20081201

• Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma.

  Journal of drug targeting 20081201

• Tanshinone IIA down-regulates the protein expression of ErbB-2 and up-regulates TNF-alpha in colon cancer cells in vitro and in vivo.

  International journal of molecular medicine 20081201

• Tanshinone IIA interacts with DNA by minor groove-binding.

  Biological & pharmaceutical bulletin 20081201

• [A full length cDNA of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase cloning and analysis of introduced gene expression in Salvia miltiorrhiza].

  Yao xue xue bao = Acta pharmaceutica Sinica 20081201

• [Study of molecular mechanism of tanshinone II A inducing differentiation in acute promyelocytic leukemia NB4 cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201

• Vascular effects of different lipophilic components of 'Danshen', a traditional Chinese medicine, in the isolated porcine coronary artery.

  Journal of natural products 20081101

• Growth inhibition and apoptosis induction by tanshinone I in human colon cancer Colo 205 cells.

  International journal of molecular medicine 20081101

• Anticancer effects of tanshinone I in human non-small cell lung cancer.

  Molecular cancer therapeutics 20081101

• [Experiment of extracting Salviae miltiorrhizae on using O/W microemulsion].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

• Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase.

  Life sciences 20081010

• Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules.

  Carcinogenesis 20081001

• Effect of tanshinone IIA on the noncovalent interaction between warfarin and human serum albumin studied by electrospray ionization mass spectrometry.

  Journal of the American Society for Mass Spectrometry 20081001

• Potency and property of DNA conformational damage determine ATM activation: two new DNA topological probes.

  Cell biochemistry and function 20081001

• Effects of tanshinone IIA on transforming growth factor beta1-Smads signal pathway in renal interstitial fibroblasts of rats.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081001

• Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model.

  Clinical and investigative medicine. Medecine clinique et experimentale 20081001

• [Study of growth inhibitory effect and apoptosis induced by different matches of Tanshinone IIA and Salvianolic Acid B on Acute Promyelocytic Leukemia cells (HL-60)].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081001

• Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels.

  Journal of ethnopharmacology 20080926

• Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest.

  Life sciences 20080912

• Growth inhibition and apoptosis induction by tanshinone IIA in human colon adenocarcinoma cells.

  Planta medica 20080901

• Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells.

  International journal of oncology 20080901

• Tanshinone IIA inhibits human breast cancer cells through increased Bax to Bcl-xL ratios.

  International journal of molecular medicine 20080901

• Determination of tanshinone I in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.

  Journal of chromatographic science 20080901

• [Mechanism of copper and zinc on tanshinones of cultivated Salvia miltiorrhiza].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• [Inhibitory effects and mechanism of tanshinone IIA on proliferation of rat aortic smooth muscle cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• Tanshinone IIA: a new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels.

  European journal of pharmacology 20080820

• Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine.

  Drug metabolism and disposition: the biological fate of chemicals 20080801

• Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways.

  Innate immunity 20080801

• Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats.

  Biological & pharmaceutical bulletin 20080801

• [Optimization of enzymatic extraction of effective constituents from fibrous roots of Salvia miltiorrhiza by central composite design and response surface method].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801

• Role of P-glycoprotein in the transport of tanshinone I, one active triterpenoid from Salvia miltiorrhiza.

  Drug metabolism letters 20080801

• [Effect of tanshinone II A on angiotensin receptor in hypertrophic myocardium of rats with pressure over-loading].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080701

• Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro.

  Phytotherapy research : PTR 20080601

• T-DNA activation tagging as a tool to isolate Salvia miltiorrhiza transgenic lines for higher yields of tanshinones.

  Planta medica 20080601

• Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge.

  Archives of pharmacal research 20080601

• [Preparation and quality evaluation of intravenous tanshinone II (A) emulsion].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

• Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway.

  Journal of cellular biochemistry 20080501

• Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza, PF2401-SF.

  Biomedical chromatography : BMC 20080501

• Effects of tanshinone IIA on the hepatotoxicity and gene expression involved in alcoholic liver disease.

  Archives of pharmacal research 20080501

• Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza).

  Xenobiotica; the fate of foreign compounds in biological systems 20080401

• [Changes of c-fos, c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin II and effects of tanshinone II A].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

• [Comparative research on pharmacodynamics of Danshen co-microemulsion on hemorheology in rats with hyperlipidemia].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080401

• Ultrahigh diterpenoid tanshinone production through repeated osmotic stress and elicitor stimulation in fed-batch culture of Salvia miltiorrhiza hairy roots.

  Applied microbiology and biotechnology 20080301

• [Comparison of tanshinone IIA in Radix Salviae Miltorrhizae from Shandong].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080301

• [Study on technical processes for extraction and purification of total tanshinones].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080301

• [Tanshinone II A inhibits in vitro cellular proliferation and migration of vascular smooth muscle cell of rabbit].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080301

• Tanshinone IIA ameliorates trinitrobenzene sulfonic acid (TNBS)-induced murine colitis.

  Digestive diseases and sciences 20080201

• Orthogonal array design for the optimization of supercritical fluid extraction of tanshinones from Danshen.

  Journal of separation science 20080201

• Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases.

  Xenobiotica; the fate of foreign compounds in biological systems 20080201

• Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis.

  Translational research : the journal of laboratory and clinical medicine 20080201

• [A new method for quick analysis of tanshinone II(A) and salvianolic acid in Fufang Danshen tablets by AOTF-near infrared spectroscopy].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

• Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit.

  Journal of ethnopharmacology 20080117

• Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101

• Comparative genotoxicity evaluation of imidazolinone herbicides in somatic cells of Drosophila melanogaster.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101

• The prediction of the hepatic clearance of tanshinone IIA in rat liver subcellular fractions: accuracy improvement.

  Current drug metabolism 20080101

• [Inhibitive effect of local perfusion of tanshinone II A nanoparticles on MMP-2 secretion].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080101

• Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin.

  The international journal of biochemistry & cell biology 20080101

• The correlation of Salvia miltiorrhiza extract-induced regulation of osteoclastogenesis with the amount of components tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone.

  Immunopharmacology and immunotoxicology 20080101

• Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071231

• Enhanced secondary metabolite (tanshinone) production of Salvia miltiorrhiza hairy roots in a novel root-bacteria coculture process.

  Applied microbiology and biotechnology 20071201

• Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201

• Growth-inhibiting and apoptosis-inducing effects of Tanshinone II A on human gastric carcinoma cells.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20071201

• [Analysis on biomasses and contents of active components in roots of Salvia miltiorrhiza from different populations].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201

• Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.

  European journal of pharmacology 20071128

• Simultaneous determination and pharmacokinetic study of water-soluble and lipid-soluble components of danshen in rat plasma using HPLC-UV method.

  Biomedical chromatography : BMC 20071101

• Establishment of a new human glioblastoma multiforme cell line (WJ1) and its partial characterization.

  Cellular and molecular neurobiology 20071101

• Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet.

  Life sciences 20071013

• PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071001

• In situ intestinal absorption behaviors of tanshinone IIA from its inclusion complex with hydroxypropyl-beta-cyclodextrin.

  Biological & pharmaceutical bulletin 20071001

• [Inhibition effects of constituents of Radix Salviae Miltiorrhizae on proliferation and procollagen transcription of dermal fibroblasts in systemic sclerosis].

  Zhonghua yi xue za zhi 20070911

• Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang.

  Journal of pharmaceutical and biomedical analysis 20070903

• Chromatographic fingerprinting analysis of Danshen root (Salvia miltiorrhiza Radix et Rhizoma) and its preparations using high performance liquid chromatography with diode array detection and electrospray mass spectrometry (HPLC-DAD-ESI/MS).

  Journal of separation science 20070901

• [In situ extraction effect of macroporous resins on tanshinones in Salvia miltiorrhiza hairy root culture].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

• [Contrast studies on content of hydrophobic components between Salvia yunnanensis roots and Salvia miltiorrhiza roots].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070901

• Complexation of tanshinone IIA with 2-hydroxypropyl-beta-cyclodextrin: effect on aqueous solubility, dissolution rate, and intestinal absorption behavior in rats.

  International journal of pharmaceutics 20070816

• Tanshinone IIA inhibits endothelin-1 production in TNF-alpha-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis.

  Acta pharmacologica Sinica 20070801

• Investigation of the improved effects of 2-hydroxypropyl-beta-cyclodextrin on solubility, dissolution rate, and intestinal absorptive profile of tanshinone IIA in rats.

  Archives of pharmacal research 20070801

• [The inhibitive effect produced by local perfusion of tanshinone IIA nanoparticle on neointimal hyperplasia of rabbit carotid artery following intimal denudation].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20070801

• Involvement of P-glycoprotein and multidrug resistance associated protein 1 in the transport of tanshinone IIB, a primary active diterpenoid quinone from the roots of Salvia miltiorrhiza, across the blood-brain barrier.

  Drug metabolism letters 20070801

• Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis.

  European journal of pharmacology 20070730

• Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.

  Journal of natural products 20070701

• [Effect of tanshinone II A on angiotensin II induced nitric oxide production and endothelial nitric oxide synthase gene expression in cultured porcine aortic endothelial cells].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070701

• [The influence of steaming processing on components in Chinese medicine by HPLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070701

• [The inhibitive effect of sodium tanshinone II A sulfonic acid on intimal hyperplasia in rabbit iliac artery ballon injury model].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070701

• Identification of tanshinones and their metabolites in rat bile after oral administration of TTE-50, a standardized extract of Salvia miltiorrhiza by HPLC-ESI-DAD-MSn.

  Journal of pharmaceutical and biomedical analysis 20070628

• Cryptotanshinone inhibits macrophage migration by impeding F-actin polymerization and filopodia extension.

  Life sciences 20070620

• Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress.

  Vascular pharmacology 20070601

• [Growth inhibition and multidrug resistance-reversing effect of tanshinone I A on human breast cancer cell with estrogen receptor negative].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070601

• Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats.

  Chinese journal of integrative medicine 20070601

• Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood-brain barrier.

  Xenobiotica; the fate of foreign compounds in biological systems 20070601

• [Preparation of tanshinone microemulsion and its absorption in rat intestine in situ].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

• [Advance of study on apoptosis inducer of several types of natural drug].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20070601

• [Quality analysis of Radix Salviae Miltiorrhizae from different habitats by HPLC and TLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070601

• [Determination of tanshinone II A and deoxyschizandrin in danshenwuweizi tablet by RP-HPLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070601

• The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells.

  Journal of ethnopharmacology 20070522

• Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats.

  Neuroscience letters 20070507

• Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells.

  Biochemical pharmacology 20070501

• Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method.

  Biomedical chromatography : BMC 20070501

• Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice.

  Chemical & pharmaceutical bulletin 20070501

• Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

  Current drug metabolism 20070501

• [Studies on chemical constituents of Prunella vulgaris].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070501

• Coupling continuous ultrasound-assisted extraction with ultrasonic probe, solid-phase extraction and high-performance liquid chromatography for the determination of sodium Danshensu and four tanshinones in Salvia miltiorrhiza bunge.

  Analytica chimica acta 20070425

• Enhancement of tanshinone production in Salvia miltiorrhiza Bunge (red or Chinese sage) hairy-root culture by hyperosmotic stress and yeast elicitor.

  Biotechnology and applied biochemistry 20070401

• Role of ATP-binding cassette drug transporters in the intestinal absorption of tanshinone IIB, one of the major active diterpenoids from the root of Salvia miltiorrhiza.

  Xenobiotica; the fate of foreign compounds in biological systems 20070401

• Simultaneous determination of four tanshinones in Salvia miltiorrhiza by pressurized liquid extraction and capillary electrochromatography.

  Journal of separation science 20070401

• [Comparison of two preparation methods applied in tanshinone II(A)-loaded PLGA nanoparticles].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

• Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells.

  Journal of neuro-oncology 20070301

• [Pharmacokinetic interactions between the main components in the extracts of Salvia miltiorrhiza Bge. in rat].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070301

• [Effects of 2-n-nonyl-1,3-dioxolane as an enhanceron transdermal absorption of Salvia miltiorrhiza gel].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070301

• Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation.

  Current drug metabolism 20070201

• [Inhibition of cell growth and induction of apoptosis in human hepatoma cell line HepG2 by tanshione IIA].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20070201

• [Effects of methyl jasmonat on accumulation and release of tanshinones in suspension cultures of Salvia miltiorrhiza hairy root].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070201

• New developments in the chemistry and biology of the bioactive constituents of Tanshen.

  Medicinal research reviews 20070101

• Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells.

  Mitochondrion 20070101

• Profiling the metabolic difference of seven tanshinones using high-performance liquid chromatography/multi-stage mass spectrometry with data-dependent acquisition.

  Rapid communications in mass spectrometry : RCM 20070101

• Study of the phase I and phase II metabolism of a mixture containing multiple tanshinones using liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• [Study on uniform-design for optimizing supercritical-CO2 fluid extraction technique of tanshinones in radix salviae].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

• Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism.

  Journal of ethnopharmacology 20061124

• Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro.

  Journal of biomedical science 20061101

• Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion.

  Planta medica 20061101

• [Complete remission of acute promyelocytic leukemia resisting all-trans retinoic acid of one case treated by tanshinone II A].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20061101

• Synthesis of novel chemical probes for the study of tanshinone binding proteins.

  Bioorganic & medicinal chemistry letters 20060915

• [Studies on in vitro culture of adventitious root in Salvia miltiorrhiza].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060901

• [Quantitative analysis on Radix Salviae miltiorrhizae by NIR].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060901

• Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways.

  European journal of pharmacology 20060807

• Addition of tanshinone IIA to UW solution decreases skeletal muscle ischemia-reperfusion injury.

  Acta pharmacologica Sinica 20060801

• [Effect of micronization on the quality of Salvia miltiorrhiza Bge].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060801

• [Protective effect of tanshinones against liver injury in mice loaded with restraint stress].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060701

• Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1.

  Experimental & molecular medicine 20060630

• Inhibition of ethanol-induced toxicity by tanshinone IIA in PC12 cells.

  Acta pharmacologica Sinica 20060601

• [Studies on absorptive mechanism of lipophilic components of danshen from its hydroxypropyl-beta-cyclodextrin inclusion complex].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20060601

• Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry.

  Journal of mass spectrometry : JMS 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• [Experimental study of effect of tanshinone on artery restenosis in rat carotid injury model].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060401

• [Initial studies of microemulsion formulation for the delivery of a combination of Tanshiones and Salvianolic acids].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060401

• [Preparation of tanshinone transfersome and its deformability].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060301

• Simultaneous quantification of cryptotanshinone and its active metabolite tanshinone IIA in plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS).

  Journal of pharmaceutical and biomedical analysis 20060213

• Identification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. A 20060203

• [Synergistic effects of biotic and abiotic elicitors on the production of tanshinones in Salvia miltiorrhiza hairy root culture].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

• [Effects of Tanshinone IIA on procoagulant activity of human ECV304 cell line induced by NB4 cells].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060101

• Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20060101

• Characterization of tanshinones in the roots of Salvia miltiorrhiza (Dan-shen) by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20060101

• High-performance liquid chromatographic determination of tanshinones in the roots of Salvia miltiorrhiza and related traditional chinese medicinal preparations.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20060101

• Determination of cryptotanshinone and its metabolite in rat plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051205

• Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use.

  Journal of clinical pharmacology 20051201

• Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-electrospray ionisation-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105

• [Analysis of four components in Fufang Danshen Tablets by high performance liquid chromatography with electrochemical and ultraviolet detections].

  Se pu = Chinese journal of chromatography 20051101

• Efficient production and recovery of diterpenoid tanshinones in Salvia miltiorrhiza hairy root cultures with in situ adsorption, elicitation and semi-continuous operation.

  Journal of biotechnology 20051010

• Partial neuroprotective effect of pretreatment with tanshinone IIA on neonatal hypoxia-ischemia brain damage.

  Pediatric research 20051001

• [Inhibitive effect to collagen fiber of tanshinone II A in iliac artery following balloon injury in rabbit].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20051001

• Potential anticancer activity of tanshinone IIA against human breast cancer.

  International journal of cancer 20050920

• Induction and potentiation of diterpenoid tanshinone accumulation in Salvia miltiorrhiza hairy roots by beta-aminobutyric acid.

  Applied microbiology and biotechnology 20050801

• Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza bunge.

  Archives of pharmacal research 20050801

• Preparation and pharmacokinetic evaluation of Tashinone IIA solid lipid nanoparticles.

  Drug development and industrial pharmacy 20050701

• [Effects of mineral cations on the accumulation of tanshinone II A and protocatechuic aldehyde in the adventitious root culture of Salvia niltiorrhiza].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050601

• Tanshinone: an inhibitor of proliferation of vascular smooth muscle cells.

  Journal of ethnopharmacology 20050513

• [A study on the cell differentiation induced by tanshinone IIA and its molecular mechanism in retinoic acid: resistant acute promyelocytic leukemia].

  Zhonghua nei ke za zhi 20050501

• [Studies on chemical constituents in roots of Peucedanum praeruptorum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050501

• Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro.

  Experimental & molecular medicine 20050430

• Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice.

  Journal of ethnopharmacology 20050426

• [Advances in study of the pharmacological effects of danshen on hemorheology].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401

• [Inhibition of proliferation and induction of apoptosis by tanshinone II A in NCI-H460 cell].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050401

• Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC.

  Journal of pharmaceutical and biomedical analysis 20050309

• Compound 278E, structurally modified from tanshinone, induces monocytic differentiation and regulates proto-oncogene expression in human leukemic HL-60 cells.

  Anti-cancer drugs 20050201

• [Alteration of activities of telomerase in tanshinone IIA inducing apoptosis of the leukemia cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201

• Determining the purity of samples from natural products by coupling HPLC and CCD spectrometry.

  Journal of separation science 20050201

• Preparation and study on the inclusion complexes of two tanshinone compounds with beta-cyclodextrin.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050101

• [The growth of Salvia miltiorrhiza seedling and root system following transplantation].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050101

• Tanshinone IIA isolated from Salvia miltiorrhiza elicits the cell death of human endothelial cells.

  Journal of biomedical science 20050101

• Tanshinone production in roots of micropropagated Salvia przewalskii Maxim.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

• Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells.

  Archives of pharmacal research 20041201

• Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.

  Journal of medicinal chemistry 20041104

• [Differentiation and apoptosis of NB4 cells synergistically induced by Tanshinone II A and all-trans retinoic acid].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20041101

• [Studies on HPLC fingerprints of tanshinone microemulsion].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041101

• [Effect of tanshinone microemulsion on reversing MDR in human tumor cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041101

• Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells.

  World journal of gastroenterology 20040715

• Identification of major active constituents in the fingerprint of Salvia miltiorrhiza Bunge developed by high-speed counter-current chromatography.

  Journal of chromatography. A 20040702

• Effects of tanshinone on neuropathological changes induced by amyloid beta-peptide(1-40) injection in rat hippocampus.

  Acta pharmacologica Sinica 20040701

• Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge.

  Biochemical pharmacology 20040501

• Tanshinone prevents cancellous bone loss induced by ovariectomy in rats.

  Acta pharmacologica Sinica 20040501

• Evaluation of pressurized liquid extraction and pressurized hot water extraction for tanshinone I and IIA in Salvia miltiorrhiza using LC and LC-ESI-MS.

  Journal of chromatographic science 20040401

• Studies on the spectroscopic behavior of cryptotanshinone, tanshinone IIA, and tanshinone I.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040301

• [Enhancement of the bystander effect by tanshinone IIA in HSV-tK/GCV system is related to expression of connexin 43 mRNA].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040301

• [Study on the characteristic of assimilating nitrogenous phosphorous fertilizer and the accumulation disciplinarian of total tanshinons of Salvia miltiorrhiza].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040301

• [The experimental study of the effect of tanshinone on artery restenosis in mouse].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040301

• Enhancement of tanshinone production in Salvia miltiorrhiza hairy root culture by Ag+ elicitation and nutrient feeding.

  Planta medica 20040201

• Induction of CYP1A by a diterpene quinone tanshinone IIA isolated from a medicinal herb Salvia miltiorrhiza in C57BL/6J but not in DBA/2J mice.

  Life sciences 20040102

• [Anticancer effect of tanshinone and its mechanisms].

  Ai zheng = Aizheng = Chinese journal of cancer 20031201

• Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells.

  Planta medica 20031101

• [Purification and fingerprinting development of Salvia miltiorrhiza Bunge by high-speed counter-current chromatography].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20031101

• Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats.

  Acta pharmacologica Sinica 20031001

• [The variation of Caspase3 activity in tanshinone induced NB4 cells apoptosis].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20030701

• [Study of Salvia przewalskii and evaluation of its uses].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030701

• Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo.

  Antimicrobial agents and chemotherapy 20030601

• [Effect of tanshinone IIA on the growth behavior of human hepatoma cell line BEL-7402 in vitro and its mechanism].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030601

• Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2.

  Xenobiotica; the fate of foreign compounds in biological systems 20030601

• [Protective effects of tanshinone IIA on injured primary cultured rat hepatocytes induced by CCl4].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030601

• Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20030501

• [Determination of tanshinone IIA in rat plasma and the pharmacokinetics by RP-HPLC method].

  Yao xue xue bao = Acta pharmaceutica Sinica 20030501

• [Studies on the extraction of ingredients from Chinese traditional medicine with CO2 supercritical fluid].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030501

• Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells.

  Pharmacology & toxicology 20030401

• Growth inhibition and apoptosis induction in human hepatoma cells by tanshinone II A.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20030101

• Novel sustained-release implant of herb extract using chitosan.

  Biomaterials 20021201

• Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses.

  Phytotherapy research : PTR 20021101

• [Medicinal resources of Salvia yunnanensis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020901

• Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza.

  Archives of pharmacal research 20020801

• [Review of germplasm resources studies on Salvia miltiorrhiza].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020701

• [Kinetic model for extraction process of Chinese traditional medicine].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020701

• Study on the relationship between NB4 cell apoptosis induced by tanshinone IIA and the cell mitochondrial transmembrane potential.

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20020601

• Separation of tanshinones from Salvia miltiorrhiza bunge by multidimensional counter-current chromatography.

  Journal of chromatography. A 20020201

• [Extraction of three tanshinones from the root of Salvia miltiorrhiza Bunge by supercritical carbon dioxide fluid and their analysis with high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20020101

• [Effect of tanshinone IIA on CCl4-induced liver fibrosis in rats].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020101

• [Study on the differentiation of K562 cell-line induced by Tanshinone II A].

  Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20020101

• [A study on apoptosis of nasopharyngeal carcinoma cell line induced by Tanshinone II A and its molecular mechanism].

  Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20020101

• Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones.

  Journal of natural products 20011101

• [Spectroscopic studies on the binding of effective component of Chinese herbs with human serum albumin].

  Guang pu xue yu guang pu fen xi = Guang pu 20011001

• [Protective effect of tanshinone IIA on acute hepatic injury in mice].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010801

• Microwave-assisted extraction of tanshinones from Salvia miltiorrhiza bunge with analysis by high-performance liquid chromatography.

  Journal of chromatography. A 20010713

• [Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010601

• [Protective effect of tanshinone on injured cultured PC12 cells in vitro].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010601

• Inhibition of serum deprivation-induced PC12 cell apoptosis by tanshinone II A.

  Acta pharmacologica Sinica 20010501

• [Study on improving the dissolution rate of tanshinone in vitro by solvent deposition method].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010301

• [SFE-CGC determination of tanshinone in Salvia miltiorrhiza Bunge].

  Yao xue xue bao = Acta pharmaceutica Sinica 20010101