57-66-9 | 4-(dipropylsulfamoyl)benzoic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	99%	in stock	$8.00	$5.00
5g	99%	in stock	$18.00	$12.00
10g	99%	in stock	$28.00	$19.00
25g	99%	in stock	$46.00	$32.00
50g	99%	in stock	$82.00	$57.00
100g	99%	in stock	$138.00	$96.00

Description

• Catalog Number: AB78599
• Chemical Name: 4-(dipropylsulfamoyl)benzoic acid
• CAS Number: 57-66-9
• Molecular Formula: C13H19NO4S
• Molecular Weight: 285.3593
• MDL Number: MFCD00038402
• SMILES: CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC

Computed Properties

• Complexity: 374
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 3.2

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  Journal of neuroscience research 20070701

• Mechanistic study on the intestinal absorption and disposition of baicalein.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701

• Characterisation of exogenous folate transport in Plasmodium falciparum.

  Molecular and biochemical parasitology 20070701

• Active renal secretion of NXY-059, a novel neuroprotectant, is mediated via an organic acid transporter.

  Journal of clinical pharmacology 20070701

• Electrokinetic migration of acidic drugs across a supported liquid membrane.

  Journal of chromatography. A 20070608

• Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells.

  Drug metabolism and disposition: the biological fate of chemicals 20070601

• Possible multiple transporters were involved in hepatobiliary excretion of antofloxacin in rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20070601

• Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid.

  Neuroscience letters 20070517

• The pancreatohepatorenal cAMP-adenosine mechanism.

  The Journal of pharmacology and experimental therapeutics 20070501

• Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

  Current drug metabolism 20070501

• Quantitation of Armillarisin A in human plasma by liquid chromatography-electrospray tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20070411

• Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins.

  European journal of pharmacology 20070410

• Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).

  Pharmaceutical research 20070401

• One center's experience: the serology and drugs associated with drug-induced immune hemolytic anemia--a new paradigm.

  Transfusion 20070401

• Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells.

  The Journal of pharmacy and pharmacology 20070401

• Progesterone inhibits folic acid transport in human trophoblasts.

  The Journal of membrane biology 20070401

• DNA damage caused by benzo(a)pyrene in MCF-7 cells is increased by verapamil, probenecid and PSC833.

  Toxicology letters 20070227

• Chiral recognition of amethopterin enantiomers by the reduced folate carrier in Caco-2 cells.

  Drug metabolism and pharmacokinetics 20070225

• Schisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1.

  Cancer letters 20070208

• Evidence of Oatp and Mdr1 in cryopreserved rat hepatocytes.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070201

• Efflux of drugs and solutes from brain: the interactive roles of diffusional transcapillary transport, bulk flow and capillary transporters.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070101

• Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model.

  Journal of neural transmission (Vienna, Austria : 1996) 20070101

• In silico prediction of pregnane X receptor activators by machine learning approaches.

  Molecular pharmacology 20070101

• [A case of papillitis revealing primary syphilis].

  Medecine et maladies infectieuses 20070101

• Mitoxantrone permeability in MDCKII cells is influenced by active influx transport.

  Molecular pharmaceutics 20070101

• Flow cytometric monitoring of multidrug drug resistance protein 1 (MRP1/ABCC1) -mediated transport of 2',7'-bis-(3-carboxypropyl)-5-(and-6)- carboxyfluorescein (BCPCF) into human erythrocyte membrane inside-out vesicles.

  Molecular membrane biology 20070101

• [Diagnosis of interstitial nephropathy caused by BK virus in renal transplantation. Therapeutic management with cidofovir plus probenecid].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20070101

• Verapamil, but not probenecid, co-administration can convert desloratadine to a sedating antihistamine in mice.

  Drug metabolism letters 20070101

• High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid.

  Circulation 20061205

• Schistosoma mansoni: biochemical characterization of lactate transporters or similar proteins.

  Experimental parasitology 20061101

• Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.

  The Journal of pharmacy and pharmacology 20061101

• Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.

  Drug metabolism and disposition: the biological fate of chemicals 20061001

• Comparison of permeation enhancing strategies for an oral factor Xa inhibitor using the Caco-2 cell monolayer model.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001

• Potential gamma-hydroxybutyric acid (GHB) drug interactions through blood-brain barrier transport inhibition: a pharmacokinetic simulation-based evaluation.

  Journal of pharmacokinetics and pharmacodynamics 20061001

• Function of multidrug resistance-associated protein 2 in acute hepatic failure rats.

  European journal of pharmacology 20060928

• Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes.

  Epilepsy research 20060901

• Membrane transporter proteins: a challenge for CNS drug development.

  Dialogues in clinical neuroscience 20060901

• Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).

  American journal of physiology. Renal physiology 20060801

• The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6) -beta-D-glucopyranoside in the human intestinal cell line caco-2.

  Pharmaceutical research 20060801

• A blistering disease: bullous erysipelas.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060801

• Efficacy of probenecid for a patient with juvenile dermatomyositis complicated with calcinosis.

  The Journal of rheumatology 20060801

• Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.

  Biopharmaceutics & drug disposition 20060701

• Tubular transporters and clearance of adefovir.

  European journal of pharmacology 20060701

• Human vascular smooth muscle cells express a urate transporter.

  Journal of the American Society of Nephrology : JASN 20060701

• Subchronic treatment with kynurenine and probenecid: effects on prepulse inhibition and firing of midbrain dopamine neurons.

  Journal of neural transmission (Vienna, Austria : 1996) 20060501

• A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors.

  Cancer chemotherapy and pharmacology 20060501

• Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid.

  Drug metabolism and disposition: the biological fate of chemicals 20060501

• Transfer of probenecid and cephalexin into breast milk.

  The Annals of pharmacotherapy 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Carrier-mediated processes at several rat brain interfaces determine the neuropharmacokinetics of morphine and morphine-6-beta-D-glucuronide.

  Life sciences 20060411

• Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

• Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.

  The Journal of pharmacology and experimental therapeutics 20060301

• Probenecid with oseltamivir for human influenza A (H5N1) virus infection?

  The New England journal of medicine 20060223

• In vivo and in vitro modulation of MDR molecules in murine thymocytes.

  International immunopharmacology 20060201

• Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy.

  Pediatric transplantation 20060201

• [Molecular mechanism in biological transport in the kidney: Urate transporter URAT1].

  Nihon rinsho. Japanese journal of clinical medicine 20060201

• A concise history of gout and hyperuricemia and their treatment.

  Arthritis research & therapy 20060101

• Elevated reactive oxygen species but not glutathione regulate mercury resistance to AML-2/DX100 cells.

  Immunopharmacology and immunotoxicology 20060101

• Febuxostat--treatment for hyperuricemia and gout?

  The New England journal of medicine 20051208

• Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: confocal microscopic analysis of secreted fluid droplets.

  The Journal of experimental biology 20051201

• Wartime tactic doubles power of scarce bird-flu drug.

  Nature 20051103

• Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules.

  The Journal of pharmacology and experimental therapeutics 20051101

• Handling of the homocysteine S-conjugate of methylmercury by renal epithelial cells: role of organic anion transporter 1 and amino acid transporters.

  The Journal of pharmacology and experimental therapeutics 20051101

• Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity.

  Drug metabolism and disposition: the biological fate of chemicals 20051101

• An update on the treatment options for gout and calcium pyrophosphate deposition.

  Expert opinion on pharmacotherapy 20051101

• Transepithelial urate transport by avian renal proximal tubule epithelium in primary culture.

  The Journal of experimental biology 20051101

• [Tubular transporters OAT1 and MRP2 and clearance of adefovir].

  Nephrologie & therapeutique 20051101

• A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.

  The Journal of pharmacology and experimental therapeutics 20051001

• Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20051001

• Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1.

  Kidney international 20051001

• Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats.

  Epilepsia 20051001

• MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid.

  International journal of cancer 20050920

• Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1.

  The Journal of pharmacology and experimental therapeutics 20050901

• Effects of active transport of 5-hydroxyindoleacetic acid on measures of serotonin metabolism in the brain.

  Neuroscience and behavioral physiology 20050901

• Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.

  Life sciences 20050826

• Phenolsulfonphthalein transport by potential-sensitive urate transport system.

  European journal of pharmacology 20050822

• Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculo virus co-expression system.

  Life sciences 20050617

• Effect of probenecid on the pharmacokinetics of carbamazepine in healthy subjects.

  European journal of clinical pharmacology 20050601

• Specificity of the fluorescein transport process in Malpighian tubules of the cricket Acheta domesticus.

  The Journal of experimental biology 20050601

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Functional expression of pig renal organic anion transporter 3 (pOAT3).

  Biochimie 20050501

• The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.

  Molecular cancer therapeutics 20050501

• Systemically administered glucosamine-kynurenic acid, but not pure kynurenic acid, is effective in decreasing the evoked activity in area CA1 of the rat hippocampus.

  European journal of pharmacology 20050418

• Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects.

  American journal of physiology. Renal physiology 20050401

• UDP-glucuronosyltransferases and clinical drug-drug interactions.

  Pharmacology & therapeutics 20050401

• Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line.

  Immunology 20050401

• Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice.

  Journal of pharmacological sciences 20050401

• Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein.

  Toxicon : official journal of the International Society on Toxinology 20050301

• Synthesis and biological testing of aminoxyls designed for long-term retention by living cells.

  Organic & biomolecular chemistry 20050221

• Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11).

  Molecular pharmacology 20050201

• Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis.

  Journal of medical virology 20050201

• Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas.

  Biochemical pharmacology 20050201

• Characterization of secretory intestinal transport of phenolsulfonphthalein.

  Drug metabolism and pharmacokinetics 20050201

• Mercury induces multidrug resistance-associated protein gene through p38 mitogen-activated protein kinase.

  Toxicology letters 20050115

• Pharmacology of drugs for hyperuricemia. Mechanisms, kinetics and interactions.

  Contributions to nephrology 20050101

• Potential utility of natural polyphenols for reversing fat-induced insulin resistance.

  Medical hypotheses 20050101

• Influence of probenecid on the delivery of morphine-6-glucuronide to the brain.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101

• Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.

  Clinical pharmacology and therapeutics 20050101

• The outcome of oropharyngeal gonorrhoea treatment with different regimens.

  International journal of STD & AIDS 20050101

• Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts.

  Anticancer research 20050101

• Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter.

  American journal of nephrology 20050101

• Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites.

  Xenobiotica; the fate of foreign compounds in biological systems 20050101

• Beta-trace protein (prostaglandin D synthase)--a stable and reliable protein in perilymph.

  German medical science : GMS e-journal 20050101

• Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

  British journal of pharmacology 20041201

• Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans.

  Anesthesiology 20041201

• Comparative effects of pyrimethamine-sulfadoxine, with and without probenecid, on Plasmodium falciparum gametocytes in children with acute, uncomplicated malaria.

  Annals of tropical medicine and parasitology 20041201

• Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease.

  Experimental neurology 20041101

• Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.

  Journal of the American Society of Nephrology : JASN 20041101

• Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study.

  Neuropharmacology 20041101

• Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier.

  Endocrinology 20040901

• Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.

  Drug metabolism and disposition: the biological fate of chemicals 20040901

• Monocarboxylate transport inhibition alters retinal function and cellular amino acid levels.

  The European journal of neuroscience 20040901

• An integrated model for the analysis of pharmacokinetic data from microdialysis experiments.

  Pharmaceutical research 20040901

• Syphilis in the HIV-infected patient: an update on epidemiology, diagnosis, and management.

  Current HIV/AIDS reports 20040901

• Endogenous kynurenic acid disrupts prepulse inhibition.

  Biological psychiatry 20040815

• Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney.

  American journal of physiology. Renal physiology 20040801

• ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages.

  Antiviral therapy 20040801

• [Synthesis of polymeric drug nanomicrospheres containing probenecid].

  Guang pu xue yu guang pu fen xi = Guang pu 20040801

• The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter.

  The Journal of physiology 20040615

• Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.

  The Journal of pharmacology and experimental therapeutics 20040601

• Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia.

  The Journal of pharmacology and experimental therapeutics 20040601

• Evaluation and comparison of MRP1 activity with three fluorescent dyes and three modulators in leukemic cell lines.

  Leukemia research 20040601

• Renal secretion of the antiviral nucleoside analog AM188 is inhibited by probenecid, p-aminohippuric acid, and cimetidine in the isolated perfused rat kidney.

  Pharmaceutical research 20040601

• Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023.

  Cancer chemotherapy and pharmacology 20040501

• Localization of heparin and low-molecular-weight heparin in the rat kidney.

  Thrombosis and haemostasis 20040501

• Open randomized study of pyrimethamine-sulphadoxine vs. pyrimethamine-sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children.

  Tropical medicine & international health : TM & IH 20040501

• Hepatobiliary excretion of berberine.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• [Role of active transport of 5-hydroxyindoleacetic acid in serotonin metabolism in the brain].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20040401

• Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa.

  Biochemical pharmacology 20040315

• Once-daily cefazolin and probenecid for skin and soft tissue infections.

  The Annals of pharmacotherapy 20040301

• Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential.

  British journal of pharmacology 20040301

• Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.

  Trends in parasitology 20040301

• Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells.

  Hypertension (Dallas, Tex. : 1979) 20040201

• Function and localization of urate transporter 1 in mouse kidney.

  Journal of the American Society of Nephrology : JASN 20040201

• [Therapy of syphilis].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20040201

• Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine.

  Journal of pharmacological sciences 20040201

• Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats.

  Epilepsy research 20040201

• Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion.

  Journal of the American Society of Nephrology : JASN 20040101

• Transport of 99mTc-MAG3 via rat renal organic anion transporter 1.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20040101

• Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.

  Epilepsy research 20040101

• Cryptosporidium parvum: effect of multi-drug reversing agents on the expression and function of ATP-binding cassette transporters.

  Experimental parasitology 20040101

• Hyperuricaemia and preeclampsia: is there a pathogenic link?

  Medical hypotheses 20040101

• Bodipy-FL-verapamil: a fluorescent probe for the study of multidrug resistance proteins.

  Cellular oncology : the official journal of the International Society for Cellular Oncology 20040101

• Two male siblings with hereditary renal hypouricemia and exercise-induced ARF.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20031201

• Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport.

  Toxicology and applied pharmacology 20031115

• Effect of probenecid and quinidine on the transport of alovudine (3'-fluorothymidine) to the rat brain studied by microdialysis.

  Pharmacology & toxicology 20031101

• Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

• Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.

  Biochemical and biophysical research communications 20031010

• Functional expression of the multidrug resistance protein 1 in microglia.

  The Journal of pharmacology and experimental therapeutics 20031001

• Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro.

  Neuropharmacology 20031001

• Sources for superoxide release: lessons from blockade of electron transport, NADPH oxidase, and anion channels in diaphragm.

  Antioxidants & redox signaling 20031001

• Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter.

  FEBS letters 20030911

• Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier.

  Journal of neurochemistry 20030901

• Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.

  Hepatology (Baltimore, Md.) 20030801

• UV or X-irradiation increases the cytoplasmic accumulation of rhodamine 123 in various cancer cell lines.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030801

• Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions.

  The Journal of biological chemistry 20030627

• Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells.

  Pharmaceutical research 20030601

• Probenecid-induced changes in the clearance of pranoprofen enantiomers.

  Chirality 20030505

• Effect of chronic probenecid therapy on cefazolin serum concentrations.

  The Annals of pharmacotherapy 20030501

• Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient.

  American journal of physiology. Renal physiology 20030401

• Control of hepatocyte DNA synthesis by intracellular pH and its role in the action of tumor promoters.

  Journal of cellular physiology 20030401

• An artificial amino acid, 4-iodo-L-meta-tyrosine: biodistribution and excretion via kidney.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030401

• Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030401

• ATP released from astrocytes during swelling activates chloride channels.

  Journal of neurophysiology 20030401

• Morphine blood-brain barrier transport is influenced by probenecid co-administration.

  Pharmaceutical research 20030401

• Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics.

  European journal of pharmacology 20030328

• Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells.

  Molecular pharmacology 20030301

• Sulfate conjugating and transport functions of MDCK distal tubular cells.

  Kidney international 20030301

• Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver.

  The Journal of pharmacology and experimental therapeutics 20030201

• Transport of 5-formyltetrahydrofolate into primary cultured rat astrocytes.

  Archives of biochemistry and biophysics 20030201

• Mechanisms by which 2',3'-dideoxyinosine (ddI) crosses the guinea-pig CNS barriers; relevance to HIV therapy.

  Journal of neurochemistry 20030201

• Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug.

  British journal of clinical pharmacology 20030201

• Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.

  Chemico-biological interactions 20030106

• Prolactin regulation of the pendrin-iodide transporter in the mammary gland.

  American journal of physiology. Endocrinology and metabolism 20030101

• Urate transport via human PAH transporter hOAT1 and its gene structure.

  Kidney international 20030101

• Pharmacokinetics and renal effects of cidofovir with a reduced dose of probenecid in HIV-infected patients with cytomegalovirus retinitis.

  Journal of clinical pharmacology 20030101

• No-wash dyes for calcium flux measurement.

  BioTechniques 20030101

• Endometritis does not predict reproductive morbidity after pelvic inflammatory disease.

  American journal of obstetrics and gynecology 20030101

• Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats.

  Pharmaceutical research 20030101

• [Drug therapy for idiopathic hyperuricemia--introduction, dose, and side effects].

  Nihon rinsho. Japanese journal of clinical medicine 20030101

• [Molecular mechanism for urinary excretion of hypoxanthine and xanthine].

  Nihon rinsho. Japanese journal of clinical medicine 20030101

• Effect of the dimeric bile acid analogue S 0960, a specific inhibitor of the apical sodium-dependent bile salt transporter in the ileum, on the renal handling of taurocholate.

  Arzneimittel-Forschung 20030101

• Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells.

  Cancer research 20021215

• Single-cell image analysis to assess ABC-transporter-mediated efflux in highly purified hematopoietic progenitors.

  Cytometry 20021201

• Screening for 18 diuretics and probenecid in doping analysis by liquid chromatography-tandem mass spectrometry.

  Biomedical chromatography : BMC 20021201

• p-Aminohippurate transport at the apical membrane in the OK kidney epithelial cell line.

  Pharmaceutical research 20021201

• Lyme disease.

  Clinical evidence 20021201

• Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease.

  Brain research 20021122

• Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells.

  Cancer chemotherapy and pharmacology 20021101

• Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid response.

  The Journal of steroid biochemistry and molecular biology 20021101

• Functional analysis of ABCA8, a new drug transporter.

  Biochemical and biophysical research communications 20021018

• Disposition of acamprosate in the rat: influence of probenecid.

  Biopharmaceutics & drug disposition 20021001

• The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1).

  AIDS (London, England) 20020906

• Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.

  Journal of pineal research 20020901

• Chronic arsenic-exposed human prostate epithelial cells exhibit stable arsenic tolerance: mechanistic implications of altered cellular glutathione and glutathione S-transferase.

  Toxicology and applied pharmacology 20020901

• Reduced gastrointestinal toxicity following inhibition of the biliary excretion of irinotecan and its metabolites by probenecid in rats.

  Pharmaceutical research 20020901

• The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats.

  Neuroscience letters 20020830

• Characterization of methotrexate transport and its drug interactions with human organic anion transporters.

  The Journal of pharmacology and experimental therapeutics 20020801

• Differential effects of p-glycoprotein and multidrug resistance protein-1 on productive human immunodeficiency virus infection.

  The Journal of infectious diseases 20020801

• Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.

  The Journal of biological chemistry 20020726

• CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20020701

• Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity.

  Journal of the American Society of Nephrology : JASN 20020701

• Outpatient pelvic inflammatory disease treatment as effective as inpatient care, study finds.

  Report on medical guidelines & outcomes research 20020614

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