578-68-7 | 4-Aminoquinoline

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$6.00	$5.00
1g	95%	in stock	$17.00	$12.00
5g	95%	in stock	$40.00	$28.00
25g	95%	in stock	$198.00	$138.00

Description

• Catalog Number: AG65904
• Chemical Name: 4-Aminoquinoline
• CAS Number: 578-68-7
• Molecular Formula: C9H8N2
• Molecular Weight: 144.1732
• MDL Number: MFCD00463448
• SMILES: Nc1ccnc2c1cccc2

Computed Properties

• Complexity: 136
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.6

Literature

• Azide-alkyne cycloaddition en route to 4-aminoquinoline-ferrocenylchalcone conjugates: synthesis and anti-TB evaluation.

  Future medicinal chemistry 20171001

• Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.

  Bioorganic & medicinal chemistry 20150901

• New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors.

  The Journal of biological chemistry 20150306

• Design and synthesis of a new class of 4-aminoquinolinyl- and 9-anilinoacridinyl Schiff base hydrazones as potent antimalarial agents.

  Chemical biology & drug design 20140801

• Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents.

  European journal of medicinal chemistry 20131101

• Synthesis and bioevaluation of novel 4-aminoquinoline-tetrazole derivatives as potent antimalarial agents.

  European journal of medicinal chemistry 20130801

• 4-aminoquinoline-triazine-based hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum.

  Chemical biology & drug design 20130501

• Synthesis and biological evaluation of a new class of 4-aminoquinoline-rhodanine hybrid as potent anti-infective agents.

  European journal of medicinal chemistry 20130401

• Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline.

  Bioorganic & medicinal chemistry 20121001

• Antiplasmodial activities of 4-aminoquinoline-statine compounds.

  Bioorganic & medicinal chemistry letters 20120915

• Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.

  Bioorganic & medicinal chemistry 20120901

• Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.

  Journal of medicinal chemistry 20120809

• Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials.

  European journal of medicinal chemistry 20120801

• Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands.

  Tropical medicine & international health : TM & IH 20120701

• Synthesis and biological activity of cymantrene and cyrhetrene 4-aminoquinoline conjugates against malaria, leishmaniasis, and trypanosomiasis.

  Dalton transactions (Cambridge, England : 2003) 20120607

• 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.

  European journal of medicinal chemistry 20120601

• In vitro antimalarial activity and molecular docking analysis of 4-aminoquinoline-clubbed 1,3,5-triazine derivatives.

  Letters in applied microbiology 20120501

• (E)-2-[2-(4-Chloro-benzyl-idene)hydrazin-1-yl]-4-{[3-(dimethyl-aza-nium-yl)prop-yl]amino}-quinazolin-1-ium bis-(perchlorate).

  Acta crystallographica. Section E, Structure reports online 20120501

• Postmortem hydroxychloroquine concentrations in nontoxic cases.

  The American journal of forensic medicine and pathology 20120301

• Reversed chloroquine molecules as a strategy to overcome resistance in malaria.

  Current topics in medicinal chemistry 20120301

• Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents.

  European journal of medicinal chemistry 20120301

• Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial.

  PLoS medicine 20120301

• Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy.

  Autophagy 20120201

• Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.

  PLoS neglected tropical diseases 20120201

• Development and application of a next-generation-sequencing (NGS) approach to detect known and novel gene defects underlying retinal diseases.

  Orphanet journal of rare diseases 20120101

• Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action.

  Malaria journal 20120101

• Biological activities of nitidine, a potential anti-malarial lead compound.

  Malaria journal 20120101

• Novel Insights into the Interplay between Apoptosis and Autophagy.

  International journal of cell biology 20120101

• Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence 'transmission blocking' assay.

  PloS one 20120101

• Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites.

  PloS one 20120101

• Synthesis and antiplasmodial activity of streptocyanine/peroxide and streptocyanine/4-aminoquinoline hybrid dyes.

  Organic & biomolecular chemistry 20111107

• The Ca2+-ATPase (SERCA1) is inhibited by 4-aminoquinoline derivatives through interference with catalytic activation by Ca2+, whereas the ATPase E2 state remains functional.

  The Journal of biological chemistry 20111104

• Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity.

  Journal of medicinal chemistry 20111027

• Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy.

  Expert opinion on drug metabolism & toxicology 20110901

• Buchwald reaction as the key step for the synthesis of metabolically more stable analogs of amodiaquine.

  European journal of medicinal chemistry 20110701

• 4-aminoquinoline analogues and its platinum (II) complexes as antimalarial agents.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110701

• Synthesis of 4-aminoquinoline analogues and their platinum(II) complexes as new antileishmanial and antitubercular agents.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110601

• Synthesis and pharmacological evaluation of bivalent antagonists of the nociceptin opioid receptor.

  European journal of medicinal chemistry 20110401

• The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance.

  ACS chemical biology 20110318

• Huprines as a new family of dual acting trypanocidal-antiplasmodial agents.

  Bioorganic & medicinal chemistry 20110301

• Plasmodium berghei K173: selection of resistance to naphthoquine in a mouse model.

  Experimental parasitology 20110201

• Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.

  Journal of medicinal chemistry 20110113

• Molecular modeling and UV-vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ).

  Bioorganic & medicinal chemistry letters 20110101

• Hepatitis C virus infection may lead to slower emergence of P. falciparum in blood.

  PloS one 20110101

• Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum.

  Malaria journal 20110101

• Monitoring of clinical efficacy and in vitro sensitivity of Plasmodium vivax to chloroquine in area along Thai Myanmar border during 2009-2010.

  Malaria journal 20110101

• Phase I randomized dose-ascending placebo-controlled trials of ferroquine--a candidate anti-malarial drug--in adults with asymptomatic Plasmodium falciparum infection.

  Malaria journal 20110101

• How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?

  Malaria journal 20110101

• Natural products as starting points for future anti-malarial therapies: going back to our roots?

  Malaria journal 20110101

• Continuous oral chloroquine as a novel route for Plasmodium prophylaxis and cure in experimental murine models.

  BMC research notes 20110101

• Prediction of inhibitory activity of epidermal growth factor receptor inhibitors using grid search-projection pursuit regression method.

  PloS one 20110101

• Development of ELISA-based methods to measure the anti-malarial drug chloroquine in plasma and in pharmaceutical formulations.

  Malaria journal 20110101

• PfMDR1: mechanisms of transport modulation by functional polymorphisms.

  PloS one 20110101

• A new high-throughput method for simultaneous detection of drug resistance associated mutations in Plasmodium vivax dhfr, dhps and mdr1 genes.

  Malaria journal 20110101

• Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening.

  Malaria journal 20110101

• Drugs for malaria: something old, something new, something borrowed.

  F1000 biology reports 20110101

• Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania.

  Malaria journal 20110101

• Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents.

  Bioorganic & medicinal chemistry letters 20101201

• Trioxaquines: hybrid molecules for the treatment of malaria.

  Drug news & perspectives 20101201

• Synthesis and antimalarial activities of rhenium bioorganometallics based on the 4-aminoquinoline structure.

  Bioorganic & medicinal chemistry 20101115

• 4-Aminoquinoline derived antimalarials: synthesis, antiplasmodial activity and heme polymerization inhibition studies.

  European journal of medicinal chemistry 20101101

• Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines.

  Bioorganic & medicinal chemistry 20100915

• Fixed artesunate-amodiaquine combined pre-formulation study for the treatment of malaria.

  International journal of pharmaceutics 20100816

• Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R).

  Bioorganic & medicinal chemistry 20100815

• A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults.

  PLoS neglected tropical diseases 20100801

• Extensive drug resistance in malaria and tuberculosis.

  Emerging infectious diseases 20100701

• Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models.

  Journal of medicinal chemistry 20100513

• Functionalized 4-aminoquinolines by rearrangement of pyrazole N-heterocyclic carbenes.

  Angewandte Chemie (International ed. in English) 20100401

• Chloroquine and its derivatives exacerbate B19V-associated anemia by promoting viral replication.

  PLoS neglected tropical diseases 20100401

• In vitro sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea.

  Tropical medicine & international health : TM & IH 20100301

• Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment.

  Molecular and biochemical parasitology 20100201

• A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells.

  European journal of medicinal chemistry 20100201

• Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo.

  Bioorganic & medicinal chemistry letters 20100201

• Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates.

  Bioorganic & medicinal chemistry letters 20100101

• Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance.

  Malaria journal 20100101

• Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type.

  Malaria journal 20100101

• Methylene blue: revisited.

  Journal of anaesthesiology, clinical pharmacology 20100101

• Structural modifications of quinoline-based antimalarial agents: Recent developments.

  Journal of pharmacy & bioallied sciences 20100101

• Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker.

  Bioorganic & medicinal chemistry 20091201

• Genetic basis of inherited macular dystrophies and implications for stem cell therapy.

  Stem cells (Dayton, Ohio) 20091101

• Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.

  Bioorganic & medicinal chemistry 20090915

• Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4-aminoquinoline with potent antiplasmodial activity.

  Bioorganic & medicinal chemistry 20090901

• Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.

  Experimental parasitology 20090701

• Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols.

  PLoS neglected tropical diseases 20090701

• In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa.

  The Journal of infectious diseases 20090601

• Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials.

  Bioorganic & medicinal chemistry letters 20090501

• Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity.

  ChemMedChem 20090401

• Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.

  Journal of medicinal chemistry 20090312

• Synthesis and in vitro antitubercular activity of a series of quinoline derivatives.

  Bioorganic & medicinal chemistry 20090215

• Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.

  Journal of medicinal chemistry 20090122

• Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.

  Journal of pharmaceutical sciences 20090101

• Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination.

  Malaria journal 20090101

• A comparative, randomized clinical trial of artemisinin/naphtoquine twice daily one day versus artemether/lumefantrine six doses regimen in children and adults with uncomplicated falciparum malaria in Côte d'Ivoire.

  Malaria journal 20090101

• 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription.

  Virology journal 20090101

• Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells.

  Malaria journal 20090101

• Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents.

  Bioorganic & medicinal chemistry letters 20081215

• Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines.

  Organic & biomolecular chemistry 20081207

• Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action.

  Molecules (Basel, Switzerland) 20081120

• New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton.

  Journal of medicinal chemistry 20081009

• Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice.

  Journal of hypertension 20081001

• Synthesis and antimalarial activity of new amino analogues of amodiaquine.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20080901

• Synthesis and antimalarial activity of novel side chain modified antimalarial agents derived from 4-aminoquinoline.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20080901

• Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase.

  Bioorganic & medicinal chemistry 20080815

• Recovery of mouse neuromuscular junctions from single and repeated injections of botulinum neurotoxin A.

  The Journal of physiology 20080701

• Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline.

  Bioorganic & medicinal chemistry letters 20080701

• Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.

  Journal of medicinal chemistry 20080313

• Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080201

• Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi.

  PloS one 20080101

• Metallocene antimalarials: the continuing quest.

  Metal-based drugs 20080101

• [Urotensin II promotes atherosclerosis].

  Seikagaku. The Journal of Japanese Biochemical Society 20080101

• The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea.

  Malaria journal 20080101

• Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population.

  Malaria journal 20080101

• Bis-quinolinium cyclophanes: highly potent and selective non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel.

  Current medicinal chemistry 20080101

• Molecular epidemiology of drug-resistant malaria in western Kenya highlands.

  BMC infectious diseases 20080101

• Pharmacodynamic interaction between 4-aminoquinolines and retinol in Plasmodium falciparum in vitro.

  Wiener klinische Wochenschrift 20080101

• 4-Amino-2-methyl-quinolinium hydrogensulfate dihydrate.

  Acta crystallographica. Section E, Structure reports online 20080101

• Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

• Chloroquine ototoxicity.

  Clinical rheumatology 20071101

• Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.

  Bioorganic & medicinal chemistry letters 20070901

• Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases.

  Biochemical pharmacology 20070615

• Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance.

  Molecular and biochemical parasitology 20070501

• Response to malaria epidemics in Africa.

  Emerging infectious diseases 20070501

• Synthesis and antimalarial activity of new isotebuquine analogues.

  Journal of medicinal chemistry 20070222

• Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives.

  Journal of medicinal chemistry 20070125

• Fujita-Ban QSAR analysis and CoMFA study of quinoline antagonists of immunostimulatory CpG-oligodeoxynucleotides.

  Bioorganic & medicinal chemistry 20070101

• Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed?

  Malaria journal 20070101

• Exploration of rate-limiting conformational state for 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl][1,1'-biphenyl]-2-ols and N(omega)-oxides (tebuquine analogues) for antimalarial activity using molecular shape analysis and molecular field analysis studies.

  Journal of chemical information and modeling 20070101

• Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses.

  Virology journal 20070101

• In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border.

  Malaria journal 20070101

• [Ocular toxicity due to 4-aminoquinoline derivatives].

  Arquivos brasileiros de oftalmologia 20070101

• Rapid selection of dhfr mutant allele in Plasmodium falciparum isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guinea.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20061101

• The use of antirheumatic disease drugs during pregnancy.

  Women's health (London, England) 20061101

• 4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

  Bioorganic & medicinal chemistry letters 20061015

• Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol.

  Bioorganic & medicinal chemistry 20060815

• Probing the role of the covalent linkage of ferrocene into a chloroquine template.

  Journal of medicinal chemistry 20060727

• Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania.

  The Journal of infectious diseases 20060615

• Genotoxicity of chloroquine in rat liver cells: protective role of free radical scavengers.

  Cell biology and toxicology 20060501

• Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro.

  Memorias do Instituto Oswaldo Cruz 20060501

• Sensitive fluorescence HPLC assay for AQ-13, a candidate aminoquinoline antimalarial, that also detects chloroquine and N-dealkylated metabolites.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060403

• Design, synthesis and antimalarial activity of a new class of iron chelators.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20060301

• Three 4-aminoquinolines of antimalarial interest.

  Acta crystallographica. Section C, Crystal structure communications 20060201

• A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.

  Current topics in medicinal chemistry 20060101

• Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine.

  Malaria journal 20060101

• Primaquine synergises the activity of chloroquine against chloroquine-resistant P. falciparum.

  Biochemical pharmacology 20051015

• Human urotensin II accelerates foam cell formation in human monocyte-derived macrophages.

  Hypertension (Dallas, Tex. : 1979) 20051001

• 4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity.

  Bioorganic & medicinal chemistry 20050915

• Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: design, construction, characterization, and pharmacology of metaquine.

  Journal of medicinal chemistry 20050825

• Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.

  Bioorganic & medicinal chemistry 20050502

• Design and synthesis of new antimalarial agents from 4-aminoquinoline.

  Bioorganic & medicinal chemistry 20050315

• Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities.

  Bioorganic & medicinal chemistry letters 20050215

• 1,4-bis(3-aminopropyl)piperazine libraries: from the discovery of classical chloroquine-like antimalarials to the identification of new targets.

  Combinatorial chemistry & high throughput screening 20050201

• Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.

  Molecular pharmaceutics 20050101

• Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].

  Malaria journal 20050101

• [Acute chloroquine intoxication--rare, but always serious: case reports and literature review].

  Przeglad lekarski 20050101

• In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine.

  Biochemical and biophysical research communications 20041008

• Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.

  Bioorganic & medicinal chemistry letters 20040802

• A new class of nonpeptide bradykinin B(2) receptor ligand, incorporating a 4-aminoquinoline framework. Identification of a key pharmacophore to determine species difference and agonist/antagonist profile.

  Journal of medicinal chemistry 20040506

• Synergistic interaction of a chloroquine metabolite with chloroquine against drug-resistant malaria parasites.

  Biochemical pharmacology 20040401

• Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs.

  Life sciences 20040305

• Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea.

  The American journal of tropical medicine and hygiene 20040301

• A correlation study of quinoline derivatives and their pharmaceutical behavior by ab initio calculated NQR parameters.

  Journal of computer-aided molecular design 20040301

• Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

  Journal of combinatorial chemistry 20040101

• Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.

  Journal of medicinal chemistry 20031106

• Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists.

  Bioorganic & medicinal chemistry letters 20031006

• Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.

  Biochemical pharmacology 20030901

• Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties.

  The Journal of antimicrobial chemotherapy 20030801

• Short report: association between chloroquine and amodiaquine resistance and allelic variation in the Plasmodium falciparum multiple drug resistance 1 gene and the chloroquine resistance transporter gene in isolates from the upper Nile in southern Sudan.

  The American journal of tropical medicine and hygiene 20030801

• Porphyrin-aminoquinoline conjugates as telomerase inhibitors.

  Organic & biomolecular chemistry 20030321

• The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids.

  Malaria journal 20030101

• Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine.

  Malaria journal 20030101

• Double-drug development against antioxidant enzymes from Plasmodium falciparum.

  Redox report : communications in free radical research 20030101

• Carbene and nitrene rearrangements: a theoretical study of cyclic allenes and carbenes, carbodiimides, and azirines.

  The Journal of organic chemistry 20021213

• 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.

  Biochemistry 20020305

• Pharmacodynamic modelling of reversible gastric acid pump inhibition in dog and man.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20011201

• A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

  Journal of medicinal chemistry 20011122

• Comparative clinical characteristics and responses to oral 4-aminoquinoline therapy of malarious children who did and did not develop 4-aminoquinoline-induced pruritus.

  Annals of tropical medicine and parasitology 20011001

• Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes and Vero cells: inhibition of channel function by chloroquine and related compounds in vitro and intoxification in vivo.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010701

• Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.

  Mini reviews in medicinal chemistry 20010701

• The additive in vitro anti-HIV-1 effect of chloroquine, when combined with zidovudine and hydroxyurea.

  Biochemical pharmacology 20010615

• Analysis of the ABCR (ABCA4) gene in 4-aminoquinoline retinopathy: is retinal toxicity by chloroquine and hydroxychloroquine related to Stargardt disease?

  American journal of ophthalmology 20010601

• Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials.

  Mini reviews in medicinal chemistry 20010501

• Antimalarial drugs in systemic lupus erythematosus: use in pregnancy.

  Drug safety 20010101