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Pro-oxidant/pro-inflammatory alterations in the offspring´s heart of mild diabetic rats are regulated by maternal treatments with a mitochondrial antioxidant.
Reproductive toxicology (Elmsford, N.Y.) 20171001
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Prevention of gentamicin-induced apoptosis with the mitochondria-targeted antioxidant mitoquinone.
The Laryngoscope 20121101
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Chemical and technological delivery systems for idebenone: a review of literature production.
Expert opinion on drug delivery 20121101
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Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation.
International journal of pharmaceutics 20120915
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Idebenone loaded solid lipid nanoparticles interact with biomembrane models: calorimetric evidence.
Molecular pharmaceutics 20120904
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Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection.
Bioorganic & medicinal chemistry 20120901
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Antioxidants and other pharmacological treatments for Friedreich ataxia.
The Cochrane database of systematic reviews 20120418
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Monogenic mitochondrial disorders.
The New England journal of medicine 20120322
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Nanostructured lipid carriers improve skin permeation and chemical stability of idebenone.
AAPS PharmSciTech 20120301
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Is Leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20120301
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Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.
Movement disorders : official journal of the Movement Disorder Society 20120301
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Assessment of neurological efficacy of idebenone in pediatric patients with Friedreich's ataxia: data from a 6-month controlled study followed by a 12-month open-label extension study.
Journal of neurology 20120201
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The effects of idebenone on mitochondrial bioenergetics.
Biochimica et biophysica acta 20120201
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Towards a modern definition of vitamin E-evidence for a quinone hypothesis.
Bioorganic & medicinal chemistry letters 20120101
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Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin.
Physiological research 20120101
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In vitro evaluation on a model of blood brain barrier of idebenone-loaded solid lipid nanoparticles.
Journal of nanoscience and nanotechnology 20120101
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Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I.
PloS one 20120101
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Determination of idebenone in plasma by HPLC with post-column fluorescence derivatization using 2-cyanoacetamide.
Chemical & pharmaceutical bulletin 20120101
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Idebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathy.
PloS one 20120101
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Effect of long-term oral treatment with L-arginine and idebenone on the prevention of stroke-like episodes in an adult MELAS patient.
Revue neurologique 20111101
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Idebenone induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells.
Neurotoxicity research 20111101
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A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy.
Brain : a journal of neurology 20110901
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Idebenone treatment in Leber's hereditary optic neuropathy.
Brain : a journal of neurology 20110901
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Treatment of Leber hereditary optic neuropathy.
Brain : a journal of neurology 20110901
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Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry 20110714
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Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A.
Naunyn-Schmiedeberg's archives of pharmacology 20110701
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α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.
Bioorganic & medicinal chemistry letters 20110615
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In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain.
Drug development and industrial pharmacy 20110601
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Idebenone as a novel, therapeutic approach for Duchenne muscular dystrophy: results from a 12 month, double-blind, randomized placebo-controlled trial.
Neuromuscular disorders : NMD 20110601
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Effects of liposomal encapsulation on the antioxidant activity of lipophilic prodrugs of idebenone.
Journal of liposome research 20110301
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Combined therapy with idebenone and deferiprone in patients with Friedreich's ataxia.
Cerebellum (London, England) 20110301
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Idebenone in Friedreich ataxia cardiomyopathy-results from a 6-month phase III study (IONIA).
American heart journal 20110301
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NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels.
PloS one 20110101
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[Idebenone (noben) -- from theory to practice].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101
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Differential expression of PGC-1α and metabolic sensors suggest age-dependent induction of mitochondrial biogenesis in Friedreich ataxia fibroblasts.
PloS one 20110101
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Updates in neuro-ophthalmology. Highlights from the 37th annual meeting of the North American Neuro-Ophthalmology Society,February 5-10, 2011, Vancouver, Canada.
Reviews in neurological diseases 20110101
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Antioxidant therapy: current status and future prospects.
Current medicinal chemistry 20110101
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Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice.
PloS one 20110101
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Antioxidant idebenone-loaded nanoparticles based on chitosan and N-carboxymethylchitosan.
Nanomedicine : nanotechnology, biology, and medicine 20101201
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Pharmacokinetic evaluation of idebenone.
Expert opinion on drug metabolism & toxicology 20101101
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Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria.
Bioorganic & medicinal chemistry 20100901
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Nitric oxide pros and cons: The role of L-arginine, a nitric oxide precursor, and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat.
Brain research bulletin 20100830
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A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia.
Archives of neurology 20100801
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Exercise capacity and idebenone intervention in children and adolescents with Friedreich ataxia.
Archives of physical medicine and rehabilitation 20100701
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Intermediate-dose idebenone and quality of life in Friedreich ataxia.
Pediatric neurology 20100501
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Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade.
Molecular genetics and metabolism 20100301
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Coenzyme Q10 in neuromuscular and neurodegenerative disorders.
Current drug targets 20100101
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Emergent and unusual allergens in cosmetics.
Dermatitis : contact, atopic, occupational, drug 20100101
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Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects.
PloS one 20100101
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[The use of noben (idebenone) in the complex treatment of episodic and chronic migraine].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101
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Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Bioorganic & medicinal chemistry letters 20091201
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Antioxidants and other pharmacological treatments for Friedreich ataxia.
The Cochrane database of systematic reviews 20091007
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Neurophysiological evaluation in children with Friedreich's ataxia.
Early human development 20091001
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Low-dose idebenone treatment in Friedreich's ataxia with and without cardiac hypertrophy.
Journal of neurology 20090901
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Characterizing gait, locomotor status, and disease severity in children and adolescents with Friedreich ataxia.
Journal of neurologic physical therapy : JNPT 20090901
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Use of Noben (idebenone) in the treatment of dementia and memory impairments without dementia.
Neuroscience and behavioral physiology 20090601
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Pharmacokinetics and metabolism of idebenone in healthy male subjects.
European journal of clinical pharmacology 20090501
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Efficacy of idebenone for respiratory failure in a patient with Leigh syndrome: a long-term follow-up study.
Journal of the neurological sciences 20090315
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Investigating idebenone and idebenone linoleate metabolism: in vitro pig ear and mouse melanocyte studies.
Journal of cosmetic dermatology 20090301
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Introduction. Idebenone in the treatment of Friedreich ataxia.
Journal of neurology 20090301
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Idebenone: an emerging therapy for Friedreich ataxia.
Journal of neurology 20090301
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Pharmacokinetic properties and metabolism of idebenone.
Journal of neurology 20090301
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Clinical experience with high-dose idebenone in Friedreich ataxia.
Journal of neurology 20090301
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Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance.
European heart journal 20090101
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Pharmacotherapy for Friedreich ataxia.
CNS drugs 20090101
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Idebenone treatment in paediatric and adult patients with Friedreich ataxia: long-term follow-up.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20081101
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Idebenone in Friedreich's ataxia.
Expert opinion on pharmacotherapy 20080901
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Allergic contact dermatitis to hydroxydecyl ubiquinone (idebenone) following application of anti-ageing cosmetic cream.
Contact dermatitis 20080901
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An update on inherited ataxias.
Current neurology and neuroscience reports 20080701
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Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
Journal of agricultural and food chemistry 20080611
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Determination of the antioxidative capacity of an antioxidant complex and idebenone: an in vitro rapid and sensitive method.
Journal of cosmetic dermatology 20080601
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Antioxidant use in Friedreich ataxia.
Journal of the neurological sciences 20080415
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Allergic contact dermatitis to idebenone in an over-the-counter anti-ageing cream.
Contact dermatitis 20080401
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Allergic contact dermatitis to hydroxydecyl ubiquinone: a newly described contact allergen in cosmetics.
Contact dermatitis 20080401
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Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone).
Journal of bioenergetics and biomembranes 20080401
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Effect of the antioxidant idebenone on adverse events under mycophenolate mofetil therapy in a rat model.
Transplantation 20080315
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Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents.
Journal of medicinal chemistry 20080214
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Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E.
Neuroreport 20080212
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Cosmeceuticals for the attenuation of extrinsic and intrinsic dermal aging.
Journal of drugs in dermatology : JDD 20080201
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Biochemical study of idebenone effect on mitochondrial metabolism of yeast.
Cell biology international 20080101
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[Noben (idebenone) in the treatment of dementia and memory impairment without dementia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101
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Effect of CoQ homologues on reactive oxygen generation by mitochondria.
BioFactors (Oxford, England) 20080101
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Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial.
The Lancet. Neurology 20071001
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A comparison of the relative antioxidant potency of L-ergothioneine and idebenone.
Journal of cosmetic dermatology 20070901
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Protective effects of Fe-Aox29, a novel antioxidant derived from a molecular combination of Idebenone and vitamin E, in immortalized fibroblasts and fibroblasts from patients with Friedreich Ataxia.
Molecular and cellular biochemistry 20070801
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Friedreich's ataxia: coenzyme Q10 and vitamin E therapy.
Mitochondrion 20070601
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Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with Friedreich ataxia.
Archives of neurology 20070601
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[Response to idebenone and multivitamin therapy in Leber's hereditary optic neuropathy].
Archivos de la Sociedad Espanola de Oftalmologia 20070601
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Neurological, cardiological, and oculomotor progression in 104 patients with Friedreich ataxia during long-term follow-up.
Archives of neurology 20070401
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Allergic contact dermatitis to idebenone used as an antioxidant in an anti-wrinkle cream.
Contact dermatitis 20070201
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Idebenone, green tea, and Coffeeberry extract: new and innovative antioxidants.
Dermatologic therapy 20070101
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[The use of noben for correction of mitochondrial disorders in Friedrich's disease].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101
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A calorimetric evaluation of the interaction of amphiphilic prodrugs of idebenone with a biomembrane model.
Journal of colloid and interface science 20060715
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Protective properties of idebenone in noise-induced hearing loss in the guinea pig.
Neuroreport 20060626
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Effect of oil phase lipophilicity on in vitro drug release from o/w microemulsions with low surfactant content.
Drug development and industrial pharmacy 20060601
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Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid.
The Journal of investigative dermatology 20060501
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone.
Biochemical and biophysical research communications 20060106
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[The use of idebenone (noben) in neurological practice].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101
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Progression despite replacement of a myopathic form of coenzyme Q10 defect.
Neurology 20040824
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Tolerability and improved protective action of idebenone-loaded pegylated liposomes on ethanol-induced injury in primary cortical astrocytes.
Journal of pharmaceutical sciences 20040701
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Idebenone delays the onset of cardiac functional alteration without correction of Fe-S enzymes deficit in a mouse model for Friedreich ataxia.
Human molecular genetics 20040515
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Quinone analogues regulate mitochondrial substrate competitive oxidation.
Biochemical and biophysical research communications 20040416
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Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients.
Neuropediatrics 20040401
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Chemical and enzymatic stability evaluation of lipoamino acid esters of idebenone.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20040301
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Idebenone treatment in Friedreich patients: one-year-long randomized placebo-controlled trial.
Neurology 20040210
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Idebenone treatment fails to slow cognitive decline in Alzheimer's disease.
Neurology 20031209
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Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis.
Free radical biology & medicine 20031201
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Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031001
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[Successful idebenone therapy of hypertrophic cardiomyopathy in Friedreich ataxia].
Orvosi hetilap 20030622
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Neurology 20030527
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Neurology 20030527
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Idebenone treatment in Friedreich's ataxia: neurological, cardiac, and biochemical monitoring.
Neurology 20030527
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A cellular model for Friedreich Ataxia reveals small-molecule glutathione peroxidase mimetics as novel treatment strategy.
Human molecular genetics 20021115
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Ethanol-induced injury in rat primary cortical astrocytes involves oxidative stress: effect of idebenone.
Neuroscience letters 20020823
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Friedreich's ataxia: idebenone treatment in early stage patients.
Neuropediatrics 20020801
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Molecular insights into Friedreich's ataxia and antioxidant-based therapies.
Trends in molecular medicine 20020501
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Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia.
Heart (British Cardiac Society) 20020401
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Heart hypertrophy and function are improved by idebenone in Friedreich's ataxia.
Free radical research 20020401
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Monitoring of idebenone treatment in patients with Friedreich's ataxia by high-pressure liquid chromatography with electrochemical detection.
Journal of neuroscience methods 20020330
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Safety and efficacy of idebenone versus tacrine in patients with Alzheimer's disease: results of a randomized, double-blind, parallel-group multicenter study.
Pharmacopsychiatry 20020101
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Improved antioxidant effect of idebenone-loaded polyethyl-2-cyanoacrylate nanocapsules tested on human fibroblasts.
Pharmaceutical research 20020101
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Coenzyme Q(10) and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits.
Molecular genetics and metabolism 20020101
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Leber's hereditary optic neuropathy (LHON/11778) with myoclonus: report of two cases.
Journal of neurology, neurosurgery, and psychiatry 20011201
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[Delayed apoptosis and its regulation in astrocytes].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010901
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Idebenone in patients with Friedreich ataxia.
Neuroscience letters 20010629
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Idebenone - monograph.
Alternative medicine review : a journal of clinical therapeutic 20010201
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Dramatic improvement in mitochondrial cardiomyopathy following treatment with idebenone.
Journal of inherited metabolic disease 20010201
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Vitamin E prevents apoptosis in cortical neurons during hypoxia and oxygen reperfusion.
Laboratory investigation; a journal of technical methods and pathology 19981101
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Idebenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in age-related cognitive disorders.
Drugs & aging 19940801
