582-24-1 | 2-Hydroxyacetophenone

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$16.00	$11.00
5g	95%	in stock	$18.00	$12.00
10g	95%	in stock	$20.00	$14.00
25g	95%	in stock	$44.00	$31.00
100g	95%	in stock	$166.00	$116.00
500g	95%	in stock	$739.00	$517.00

Description

• Catalog Number: AB62346
• Chemical Name: 2-Hydroxyacetophenone
• CAS Number: 582-24-1
• Molecular Formula: C8H8O2
• Molecular Weight: 136.1479
• MDL Number: MFCD00041829
• SMILES: OCC(=O)c1ccccc1
• NSC Number: 171232

Computed Properties

• Complexity: 114
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.1

Literature

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  Parkinsonism & related disorders 20090201

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  Molecular pain 20090101

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  Movement disorders : official journal of the Movement Disorder Society 20080915

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• Dichloridobis(2-{1-[2-(1H-indol-3-yl)ethyl-iminio]eth-yl}phenolate-κO)zinc(II)-2-{1-[2-(1H-indol-3-yl)ethyl-iminio]eth-yl}phenolate (1/2).

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  The European journal of neuroscience 20070801

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  Molecular and cellular neurosciences 20070601

• Activation of group I metabotropic glutamate receptors on main olfactory bulb granule cells and periglomerular cells enhances synaptic inhibition of mitral cells.

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• Recurrent dendrodendritic inhibition of accessory olfactory bulb mitral cells requires activation of group I metabotropic glutamate receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070523

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  Letters in applied microbiology 20070501

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• Axon-glia communication evokes calcium signaling in olfactory ensheathing cells of the developing olfactory bulb.

  Glia 20070301

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  Molecular and cellular neurosciences 20070301

• Developmental dependence, the role of the kinases p38 MAPK and PKC, and the involvement of tumor necrosis factor-R1 in the induction of mGlu-5 LTD in the dentate gyrus.

  Neuroscience 20070105

• Priming of long-term potentiation mediated by ryanodine receptor activation in rat hippocampal slices.

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• Unique regulation of long term potentiation in the rat ventral hippocampus.

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• JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1.

  The European journal of neuroscience 20070101

• Retrograde endocannabinoid inhibition of goldfish retinal cones is mediated by 2-arachidonoyl glycerol.

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  The Journal of chemical physics 20061207

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  European journal of pharmacology 20061010

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  Neurochemistry international 20060901

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  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040601

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• Using model complexes to augment and advance metalloproteinase inhibitor design.

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• Mechanisms of postspaceflight orthostatic hypotension: low alpha1-adrenergic receptor responses before flight and central autonomic dysregulation postflight.

  American journal of physiology. Heart and circulatory physiology 20040401

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• Method for simultaneous measurement of norepinephrine, 3-methoxy-4-hydroxyphenylglycol and 3,4-dihydroxyphenylglycol by liquid chromatography with electrochemical detection: application in rat cerebral cortex and plasma after lithium chloride treatment.

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• Expression and functional properties of group I metabotropic glutamate receptors in bovine chromaffin cells.

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• Alpha-hydroxyketones as inhibitors of urease.

  Bioorganic & medicinal chemistry 20040115

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  Molecular diversity 20040101

• Blockade of excitatory amino acid transporters in the rat hippocampus results in enhanced activation of group I and group III metabotropic glutamate receptors.

  Neuropharmacology 20031201

• Hippocampal mGluR1 and consolidation of contextual fear conditioning.

  Brain research bulletin 20031115

• In vivo monitoring of norepinephrine and its metabolites in skeletal muscle.

  Neurochemistry international 20031101

• mGluRs: a target for pharmacotherapy in Parkinson disease.

  Experimental neurology 20031101

• Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta.

  The European journal of neuroscience 20031101

• Elucidation of Homer 1a function in the nucleus accumbens using adenovirus gene transfer technology.

  Annals of the New York Academy of Sciences 20031101

• Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant mice.

  Annals of the New York Academy of Sciences 20031101

• Changes in hippocampal gene expression after neuroprotective activation of group I metabotropic glutamate receptors.

  Brain research. Molecular brain research 20031007

• Electroencephalographic burst suppression versus loss of reflexes anesthesia with propofol or thiopental: differences of variance in the catecholamine and cardiovascular response to tracheal intubation.

  Anesthesia and analgesia 20031001

• Involvement of transient receptor potential-like channels in responses to mGluR-I activation in midbrain dopamine neurons.

  The European journal of neuroscience 20031001

• Distinct subtypes of group I metabotropic glutamate receptors on rat spinal neurons mediate complex facilitatory and inhibitory effects.

  The European journal of neuroscience 20031001

• Hydroxyl radicals release in rat striatum involves metabotropic glutamate receptors.

  Brain research bulletin 20030830

• Endocannabinoids contribute to short-term but not long-term mGluR-induced depression in the hippocampus.

  The European journal of neuroscience 20030801

• Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.

  Neuron 20030717

• Group I mGluR ligands fail to affect 6-hydroxydopamine- induced death and glutamate release of PC12 cells.

  Acta pharmacologica Sinica 20030701

• Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotension.

  Clinical science (London, England : 1979) 20030601

• 6-(2-Hydroxybenzoyl)-5-(pyrrol-2-yl)-3H-pyrrolizine.

  Acta crystallographica. Section C, Crystal structure communications 20030601

• Intracellular calcium release resulting from mGluR1 receptor activation modulates GABAA currents in wide-field retinal amacrine cells: a study with caffeine.

  The European journal of neuroscience 20030601

• Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability.

  Neuron 20030508

• Spectroscopic studies on chromotropic mixed-ligand copper(II) complexes containing o-hydroxy benzoyl derivatives and dinitrogen bases.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030501

• Acute electrophysiologic effects of intravenous amiodarone are independent of a sympatholytic action in humans.

  Journal of cardiovascular pharmacology 20030501

• Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension.

  Neurology 20030422

• Spectral studies and structure of a 2-hydroxyacetophenone 3-hexamethyleneiminyl thiosemicarbazonate(-2) copper(II) complex containing 1,10-phenanthroline.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030401

• Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat.

  Neuropharmacology 20030301

• Interactions between adenosine and metabotropic glutamate receptors in the rat hippocampal slice.

  British journal of pharmacology 20030301

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  Epilepsy research 20030301

• Group I metabotropic glutamate receptor-mediated calcium signalling and immediate early gene expression in cultured rat striatal neurons.

  The European journal of neuroscience 20030201

• Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices.

  The Journal of physiology 20030115

• Dual modulation of gabaergic transmission by metabotropic glutamate receptors in rat ventral tegmental area.

  Neuroscience 20030101

• The role of Ca2+ in the generation of spontaneous astrocytic Ca2+ oscillations.

  Neuroscience 20030101

• Mechanisms underlying the inhibition of long-term potentiation by preconditioning stimulation in the hippocampus in vitro.

  Neuroscience 20030101

• Autonomic control after blockade of the norepinephrine transporter: a model of orthostatic intolerance.

  Journal of applied physiology (Bethesda, Md. : 1985) 20021201

• Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene.

  Endocrinology 20021201

• Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.

  Circulation 20021029

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  Hearing research 20021001

• Recent progress in asymmetric two-center catalysis.

  Chemical communications (Cambridge, England) 20020921

• NMDA-induced phosphorylation and regulation of mGluR5.

  Pharmacology, biochemistry, and behavior 20020901

• Metabotropic and NMDA glutamate receptor interactions with osmotic stimuli in supraoptic neurons.

  Pharmacology, biochemistry, and behavior 20020901

• Glutamate cascade to cAMP response element-binding protein phosphorylation in cultured striatal neurons through calcium-coupled group I metabotropic glutamate receptors.

  Molecular pharmacology 20020901

• Synthesis and metal ion uptake studies of chelating resins derived from formaldehyde-furfuraldehyde condensed phenolic Schiff bases of 4,4'-diaminodiphenylether and o-hydroxyacetophenone.

  Talanta 20020719

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  The Journal of physiology 20020615

• Long-term pharmacoclinical follow-up in schizophrenic patients treated with risperidone. Plasma and red blood cell concentrations of risperidone and its 9-hydroxymetabolite and their relationship to whole blood serotonin and tryptophan, plasma homovanillic acid, 5-hydroxyindoleacetic acid, dihydroxyphenylethyleneglycol and clinical evaluations.

  Progress in neuro-psychopharmacology & biological psychiatry 20020601

• Mechanisms and physiological role of enhancement of mGlu5 receptor function by group II mGlu receptor activation in rat perirhinal cortex.

  The Journal of physiology 20020501

• Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus.

  Brain research bulletin 20020501

• A comparative photomechanistic study (spin trapping, EPR spectroscopy, transient kinetics, photoproducts) of nucleoside oxidation (dG and 8-oxodG) by triplet-excited acetophenones and by the radicals generated from alpha-oxy-substituted derivatives through Norrish-type I cleavage.

  Journal of the American Chemical Society 20020417

• Androgen induced norepinephrine release from postganglionic neurons mediates accessory sex organ smooth muscle proliferation.

  The Journal of urology 20020401

• Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia.

  Autonomic neuroscience : basic & clinical 20020318

• Norepinephrine turnover is increased in suprabulbar subcortical brain regions and is related to whole-body sympathetic activity in human heart failure.

  Circulation 20020305

• Postsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region.

  Journal of neurophysiology 20020301

• Group I metabotropic glutamate receptors activate burst firing in rat midbrain dopaminergic neurons.

  Neuropharmacology 20020301

• Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation.

  The European journal of neuroscience 20020301

• Spiroiminodihydantoin is a major product in the photooxidation of 2'-deoxyguanosine by the triplet states and oxyl radicals generated from hydroxyacetophenone photolysis and dioxetane thermolysis.

  Organic letters 20020221

• Influence of leptin on neurotransmitter overflow from the rat brain in vitro.

  Regulatory peptides 20020215

• Local sympathetic function in human skeletal muscle and adipose tissue assessed by microdialysis.

  Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20020201

• Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice.

  The European journal of neuroscience 20020101

• Norepinephrine metabolism in neuron: dissociation between 3,4-dihydroxyphenylglycol and 3,4-dihydroxymandelic acid pathways.

  Acta pharmacologica Sinica 20020101

• Neurotransmission of the cochlear inner hair cell synapse--implications for inner ear therapy.

  Advances in oto-rhino-laryngology 20020101

• Interactions between ionotropic and metabotropic glutamate receptors regulate cAMP response element-binding protein phosphorylation in cultured striatal neurons.

  Neuroscience 20020101

• Octreotide-induced suppression of the hyperglycemic response to neostigmine or bombesin: relationship to hypothalamic noradrenergic drive.

  Brain research 20011116

• Internalization of ionotropic glutamate receptors in response to mGluR activation.

  Nature neuroscience 20011101

• Effects of metabotropic glutamate receptor agonists and antagonists on D-aspartate release from mouse cerebral cortical and striatal slices.

  Neurochemical research 20011101

• Group I metabotropic glutamate receptor activation increases phosphorylation of cAMP response element-binding protein, Elk-1, and extracellular signal-regulated kinases in rat dorsal striatum.

  Brain research. Molecular brain research 20011019

• Metabotropic glutamate receptors stimulate phospholipase D via different pathways in the adult and neonate rat hippocampus.

  Neurochemical research 20011001

• The effect of magnesium deficiency on volatile anaesthetic requirement in the rat: the role of central noradrenergic neuronal activity.

  Magnesium research 20010901

• Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors.

  Neuron 20010816

• Priming stimulation of group II metabotropic glutamate receptors inhibits the subsequent induction of rat hippocampal long-term depression in vitro.

  Neuroscience letters 20010706

• Effect of cardiac sympathetic nervous activity on mode of death in congestive heart failure.

  European heart journal 20010701

• Metabotropic glutamate receptor subtypes modulating neurotransmission at parallel fibre-Purkinje cell synapses in rat cerebellum.

  Neuropharmacology 20010701

• Noradrenaline synthesis, release and vesicular transport in the rat brain following subarachnoid haemorrhage.

  Brain research bulletin 20010701

• Effect of microgravity on plasma catecholamine responses to stressors during space flight.

  Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 20010701

• Exacerbation of neuronal cell death by activation of group I metabotropic glutamate receptors: role of NMDA receptors and arachidonic acid release.

  Experimental neurology 20010601

• Multifunctional asymmetric catalysis.

  Chemical & pharmaceutical bulletin 20010501

• Central suppressive effect of octreotide on the hyperglycemic response to 2-deoxy-D-glucose injection or cold-swim stress in awake rats: possible mediation role of hypothalamic noradrenergic drive.

  Brain research 20010323

• Inverse relationship between plasma epinephrine and testosterone levels during acute glucoprivation in healthy men.

  Life sciences 20010309

• Dialysate dihydroxyphenylglycol as a window for in situ axoplasmic norepinephrine disposition.

  Neurochemistry international 20010301

• Protein phosphatase inhibitors facilitate DHPG-induced LTD in the CA1 region of the hippocampus.

  British journal of pharmacology 20010301

• Pyriform cortex beta-waves: odor-specific sensitization following repeated olfactory stimulation.

  Brain research 20010223

• Norepinephrine reuptake is impaired in skeletal muscle of hypertensive rats in vivo.

  Hypertension (Dallas, Tex. : 1979) 20010201

• Upregulation of preprodynorphin and preproenkephalin mRNA expression by selective activation of group I metabotropic glutamate receptors in characterized primary cultures of rat striatal neurons.

  Brain research. Molecular brain research 20010131

• Myocardial interstitial norepinephrine and dihydroxyphenylglycol levels during ischemia and reperfusion.

  Cardiovascular research 20010101

• Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats.

  British journal of pharmacology 20010101

• Comparison of nitrophenylethyl and hydroxyphenacyl caging groups.

  Biopolymers 20010101

• Toluene and ethylbenzene oxidation by purified naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4.

  Applied and environmental microbiology 19960901