58546-54-6 | Gomisin A

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$42.00	$29.00
5mg	98%(HPLC)	in stock	$119.00	$83.00
10mg	98%(HPLC)	in stock	$203.00	$142.00
20mg		in stock	$394.00	$276.00
25mg	98%(HPLC)	in stock	$418.00	$293.00

Description

• Catalog Number: AB78931
• Chemical Name: Gomisin A
• CAS Number: 58546-54-6
• Molecular Formula: C23H28O7
• Molecular Weight: 416.4642
• MDL Number: MFCD01941645
• SMILES: COc1cc2CC(C)(O)C(C)Cc3c(c2c(c1OC)OC)c(OC)c1c(c3)OCO1

Computed Properties

• Complexity: 588
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• Undefined Atom Stereocenter Count: 2
• XLogP3: 3.9

Literature

• Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.

  Chemico-biological interactions 20150425

• Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.

  Toxicological sciences : an official journal of the Society of Toxicology 20150101

• Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140101

• Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability.

  Hypertension research : official journal of the Japanese Society of Hypertension 20120901

• Production of lignans in calluses of Schisandra chinensis.

  Journal of natural medicines 20120401

• The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury.

  Biological & pharmaceutical bulletin 20120101

• The role of the lignan constituents in the effect of Schisandra chinensis fruit extract on penile erection.

  Phytotherapy research : PTR 20111201

• Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.

  Molecules (Basel, Switzerland) 20110503

• Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS.

  Phytochemical analysis : PCA 20110101

• Effects of gomisin A on vascular contraction in rat aortic rings.

  Naunyn-Schmiedeberg's archives of pharmacology 20110101

• Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100701

• [Research on liposoluble ingredients of Quchiling].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

• Gomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cells.

  Journal of ethnopharmacology 20090907

• [Study on the chemical constituents of the fruit handles from Schizandra chinensis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090701

• Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice.

  Journal of pharmacological sciences 20080201

• Amyloid-beta-induced cytotoxicity of PC-12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction.

  Journal of pharmacological sciences 20070501

• Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells.

  Biochemical pharmacology 20060928

• Gomisin A improves scopolamine-induced memory impairment in mice.

  European journal of pharmacology 20060807

• Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats.

  The Journal of pharmacology and experimental therapeutics 20060301

• Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.

  Journal of neuroscience research 20040501

• Effects of gomisin A on the promotor action and serum bile acid concentration in hepatocarcinogenesis induced by 3'-methyl-4-dimethylamino-azobenzene.

  Biological & pharmaceutical bulletin 19951001