587871-26-9 | KU-55933

Packsize	Purity	Availability	Price	Discounted Price
1mg	96+%	in stock	$13.00	$9.00
5mg	96+%	in stock	$32.00	$22.00
10mg	96+%	in stock	$46.00	$33.00
100mg	98%(HPLC)	in stock	$415.00	$291.00
250mg	98%(HPLC)	in stock	$701.00	$491.00

Description

• Catalog Number: AG65553
• Chemical Name: KU-55933
• CAS Number: 587871-26-9
• Molecular Formula: C21H17NO3S2
• Molecular Weight: 395.4946
• MDL Number: MFCD08276985
• SMILES: O=c1cc(oc(c1)c1cccc2c1Sc1ccccc1S2)N1CCOCC1

Computed Properties

• Complexity: 643
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• XLogP3: 3.9

Literature

• 1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism.

  Toxicology letters 20170415

• Sterigmatocystin-induced checkpoint adaptation depends on Chk1 in immortalized human gastric epithelial cells in vitro.

  Archives of toxicology 20170101

• The ovarian DNA damage repair response is induced prior to phosphoramide mustard-induced follicle depletion, and ataxia telangiectasia mutated inhibition prevents PM-induced follicle depletion.

  Toxicology and applied pharmacology 20160201

• Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis.

  Chemical research in toxicology 20160119

• Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics.

  Environmental health perspectives 20160101

• γ-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

  Toxicology in vitro : an international journal published in association with BIBRA 20151001

• Repairing of N-mustard derivative BO-1055 induced DNA damage requires NER, HR, and MGMT-dependent DNA repair mechanisms.

  Oncotarget 20150922

• The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.

  Molecular and cellular biology 20150401

• Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity.

  Nucleic acids research 20141110

• Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response.

  The Journal of pharmacology and experimental therapeutics 20140701

• Direct activation of ATM by resveratrol under oxidizing conditions.

  PloS one 20140101

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Osteoblasts survive the arsenic trioxide treatment by activation of ATM-mediated pathway.

  Biochemical pharmacology 20130401

• The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?

  The Journal of pharmacology and experimental therapeutics 20121201

• Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells.

  Oral oncology 20121101

• Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells.

  DNA repair 20121101

• Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.

  Toxicology 20120904

• Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

  Bioorganic & medicinal chemistry letters 20120901

• Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells.

  Chinese journal of cancer 20120801

• DNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATM.

  Chemical research in toxicology 20120716

• Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.

  The Journal of biological chemistry 20120504

• ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability.

  Cell cycle (Georgetown, Tex.) 20120501

• Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death.

  Biochemical and biophysical research communications 20120330

• Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.

  Chembiochem : a European journal of chemical biology 20120319

• Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.

  Biochemical pharmacology 20120315

• DNA damage responses in cells exposed to sulphur mustard.

  Toxicology letters 20120225

• The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals.

  Toxicological sciences : an official journal of the Society of Toxicology 20120101

• DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines.

  PloS one 20120101

• Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A.

  PloS one 20120101

• Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.

  The Journal of biological chemistry 20111111

• AT cells are not radiosensitive for simple chromosomal exchanges at low dose.

  Mutation research 20111101

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.

  Oncogene 20111013

• DNA damage-sensing kinases mediate the mouse 2-cell embryo's response to genotoxic stress.

  Biology of reproduction 20110901

• DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.

  Molecular pharmacology 20110801

• 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.

  Toxicology and applied pharmacology 20110801

• Asperlin induces G₂/M arrest through ROS generation and ATM pathway in human cervical carcinoma cells.

  Biochemical and biophysical research communications 20110610

• KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.

  Nature structural & molecular biology 20110605

• Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells.

  Apoptosis : an international journal on programmed cell death 20110501

• Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.

  Journal of medicinal chemistry 20110414

• Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

  Nature chemical biology 20110413

• Impact of G₂ checkpoint defect on centromeric instability.

  Oncogene 20110317

• Three independent mechanisms for arrest in G2 after ionizing radiation.

  Cell cycle (Georgetown, Tex.) 20110301

• [The role of DNA double strains damage repairing mechanisms in high glucose-induced endothelial senescence].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110301

• Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-κB activation.

  DNA repair 20110207

• ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.

  The EMBO journal 20110202

• Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

  Nature genetics 20110201

• Targeting the DNA double strand break repair machinery in prostate cancer.

  PloS one 20110101

• Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.

  PloS one 20110101

• ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.

  Science signaling 20101207

• Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease.

  Cellular and molecular life sciences : CMLS 20101101

• Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.

  The Journal of biological chemistry 20101022

• ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.

  Molecular cell 20101008

• Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.

  International journal of radiation oncology, biology, physics 20100901

• DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin.

  Toxicological sciences : an official journal of the Society of Toxicology 20100501

• ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation.

  Journal of cellular biochemistry 20100501

• The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.

  Molecular cancer therapeutics 20100101

• Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent.

  International journal of radiation oncology, biology, physics 20091201

• Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.

  Molecular cancer therapeutics 20091001

• ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions.

  International journal of radiation oncology, biology, physics 20090901

• Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.

  Carcinogenesis 20090801

• Coactivation of ATM/ERK/NF-kappaB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes.

  Free radical biology & medicine 20090601

• Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells.

  Cancer research 20090415

• ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype.

  Blood 20090409

• Cadmium-induced adaptive response in cells of Chinese hamster ovary cell lines with varying DNA repair capacity.

  Radiation research 20090401

• DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide.

  Toxicology 20090329

• DNA double helix unwinding triggers transcription block-dependent apoptosis: a semiquantitative probe of the response of ATM, RNAPII, and p53 to two DNA intercalators.

  Chemical research in toxicology 20090316

• The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.

  Radiation oncology (London, England) 20090101

• p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.

  Oncogene 20080605

• Chk1 and Claspin potentiate PCNA ubiquitination.

  Genes & development 20080501

• Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080315

• Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling.

  DNA repair 20080301

• A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.

  Nature chemical biology 20080201

• Rapid activation of ATM on DNA flanking double-strand breaks.

  Nature cell biology 20071101

• Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.

  Journal of medicinal chemistry 20070419

• Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.

  Cancer research 20070201

• Small molecule-based reversible reprogramming of cellular lifespan.

  Nature chemical biology 20060701

• Emerging cancer therapeutic opportunities target DNA-repair systems.

  Trends in pharmacological sciences 20060601

• Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.

  Nucleic acids research 20060101

• Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.

  Biochemical pharmacology 20051219

• hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.

  Cell 20051216

• Features of selective kinase inhibitors.

  Chemistry & biology 20050601

• Chronicles in drug discovery.

  Drug news & perspectives 20050601

• Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.

  Nature cell biology 20050501

• ATM: HIV-1's Achilles heel?

  Nature cell biology 20050501

• Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.

  Cancer research 20041215