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Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3'-bioxindoles.
Organic & biomolecular chemistry 20121128
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Enantioselective construction of multifunctionalized spirocyclohexaneoxindoles through organocatalytic Michael-Aldol cyclization of isatin derived alkenes with linear dialdehydes.
Organic & biomolecular chemistry 20121128
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Aza-oxindole synthesis via base promoted Truce-Smiles rearrangement.
Chemical communications (Cambridge, England) 20121118
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Enantioselective Michael addition of 3-aryloxindoles to a vinyl bisphosphonate ester catalyzed by a cinchona alkaloid derived thiourea catalyst.
Organic & biomolecular chemistry 20121021
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Synthesis of oxindolyl pyrazolines and 3-amino oxindole building blocks via a nitrile imine [3 + 2] cycloaddition strategy.
Organic letters 20121019
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Facile synthesis of dispirooxindole-fused heterocycles via domino 1,4-dipolar addition and Diels-Alder reaction of in situ generated Huisgen 1,4-dipoles.
Organic letters 20121019
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Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer.
Journal of medicinal chemistry 20120927
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Spiro-fused pyrrolidine, piperidine, and oxindole scaffolds from lactams.
Organic letters 20120921
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Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists.
Bioorganic & medicinal chemistry 20120915
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Application of the systems chemistry approach on the ammonolysis of 1-ethoxycarbonyl- and 1-phenoxycarbonyl-3-(2-thienyl)oxindoles. A method to predict reactivity.
The Journal of organic chemistry 20120907
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Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease.
Bioorganic & medicinal chemistry letters 20120901
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Highly enantioselective trapping of zwitterionic intermediates by imines.
Nature chemistry 20120901
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1-Methyl-1'-(4-methyl-phen-yl)-2',3',5',6',7',7a'-hexa-hydro-1'H-dispiro-[piperidine-3,2'-pyrrolizine-3',3''-indoline]-4,2''-dione.
Acta crystallographica. Section E, Structure reports online 20120901
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Indole peroxygenase activity of indoleamine 2,3-dioxygenase.
Proceedings of the National Academy of Sciences of the United States of America 20120828
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Copper-catalyzed domino coupling reaction: an efficient method to synthesize oxindoles.
Organic & biomolecular chemistry 20120821
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Domino carbopalladation-cross-coupling for the synthesis of 3,3-disubstituted oxindoles.
Organic letters 20120803
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Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins.
Organic letters 20120803
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Synthesis, characterization and in vitro antimicrobial evaluation of new compounds incorporating oxindole nucleus.
Journal of enzyme inhibition and medicinal chemistry 20120801
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Enamino-oxindole HIV protease inhibitors.
Bioorganic & medicinal chemistry letters 20120801
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The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 20120801
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Development and full validation of an UPLC-MS/MS method for the determination of an anti-allergic indolinone derivative in rat plasma, and application to a preliminary pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120801
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A labeled substrate approach to discovery of biocatalytic reactions: a proof of concept transformation with N-methylindole.
Journal of the American Chemical Society 20120801
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Catalytic and enantioselective α-functionalization of oxindoles through oxidative reactions with naphthoquinones.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120727
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InCl3-mediated addition of indole to isatogens: an expeditious synthesis of 13-deoxy-isatisine A.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120727
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Multicomponent reaction to construct spirocyclic oxindoles with a Michael (triple Michael)/cyclization cascade sequence as the key step.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120727
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Strategies for the enantioselective synthesis of spirooxindoles.
Organic & biomolecular chemistry 20120721
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Enantioselective synthesis of 3,3'-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction.
Organic & biomolecular chemistry 20120721
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Organocatalytic enantioselective stereoablative hydroxylation of 3-halooxindoles: an effective method for the construction of enantioenriched 3-substituted 3-hydroxy-2-oxindoles.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120716
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Catalytic asymmetric synthesis of spirooxindoles by a mannich-type reaction of isothiocyanato oxindoles.
Angewandte Chemie (International ed. in English) 20120709
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Diastereodivergent synthesis of 3-spirocyclopropyl-2-oxindoles through direct enantioselective cyclopropanation of oxindoles.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120702
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Catalytic asymmetric exo'-selective [3+2] cycloaddition for constructing stereochemically diversified spiro[pyrrolidin-3,3'-oxindole]s.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120702
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(3Z,3'E)-3,3'-[Cyclo-hexane-1,2-diylbis(aza-nylyl-idene)]bis-(indolin-2-one) N,N-dimethyl-formamide monosolvate dihydrate.
Acta crystallographica. Section E, Structure reports online 20120701
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3-[(E)-Benzyl-idene]indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20120701
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Enantioselective Michael addition of 3-aryl-substituted oxindoles to methyl vinyl ketone catalyzed by a binaphthyl-modified bifunctional organocatalyst.
Molecules (Basel, Switzerland) 20120618
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Catalytic asymmetric sulfenylation of unprotected 3-substituted oxindoles.
Organic letters 20120601
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5-Methyl-3,3-bis-(4-methyl-piperazin-1-yl)-1-[2-(4-methyl-piperazin-1-yl)eth-yl]indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20120601
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1,5-Bis(2-oxoindolin-3-yl-idene)thio-carbonohydrazide tetra-hydro-furan monosolvate.
Acta crystallographica. Section E, Structure reports online 20120601
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Bicyclic guanidine-catalyzed asymmetric Michael additions of 3-benzyl-substituted oxindoles to N-maleimides.
Chemical communications (Cambridge, England) 20120525
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Organocatalytic asymmetric conjugate addition of 3-monosubstituted oxindoles to (E)-1,4-diaryl-2-buten-1,4-diones: a strategy for the indirect enantioselective furanylation and pyrrolylation of 3-alkyloxindoles.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120521
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Phenyliodine bis(trifluoroacetate)-mediated oxidative C-C bond formation: synthesis of 3-hydroxy-2-oxindoles and spirooxindoles from anilides.
Organic letters 20120504
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Access to spirocyclic oxindoles via N-heterocyclic carbene-catalyzed reactions of enals and oxindole-derived α,β-unsaturated imines.
Organic letters 20120504
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A novel class of sugar-based ether-linked-dispirooxindolo-pyrrolidines/pyrrolizidines through [3+2]-cycloaddition of azomethine ylides.
Carbohydrate research 20120501
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Intramolecular 1,3-dipolar cycloaddition reactions in the synthesis of complex annelated quinolines, α-carbolines and coumarins.
Molecular diversity 20120501
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Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity.
European journal of medicinal chemistry 20120501
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A catalytic metal-free Ritter reaction to 3-substituted 3-aminooxindoles.
Organic & biomolecular chemistry 20120428
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Ionic nucleophilic catalysis of chiral ammonium betaines for highly stereoselective aldol reaction from oxindole-derived vinylic carbonates.
Journal of the American Chemical Society 20120425
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Catalytic stereoselective synthesis of diverse oxindoles and spirooxindoles from isatins.
ACS combinatorial science 20120409
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Zinc-mediated diastereoselective synthesis of 3-amino oxindoles by addition of methyl and terminal alkynes to N-tert-butanesulfinyl ketimines.
The Journal of organic chemistry 20120406
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Ring enlargement versus selenoetherification on the reaction of allenyl oxindoles with selenenylating reagents.
The Journal of organic chemistry 20120406
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Protective effect of isorhynchophylline against β-amyloid-induced neurotoxicity in PC12 cells.
Cellular and molecular neurobiology 20120401
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Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists.
Bioorganic & medicinal chemistry letters 20120401
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Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy.
Bioorganic & medicinal chemistry letters 20120401
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5-Chloro-spiro-[indoline-3,7'-6H,7H,8H-pyrano[3,2-c:5,6-c']di[1]benzopyran]-2,6',8'-trione.
Acta crystallographica. Section E, Structure reports online 20120401
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5-Methyl-spiro-[indoline-3,7'-[6H,7H,8H]pyrano[3,2-c:5,6-c']di[1]benzopyran]-2,6',8'-trione chloroform hemisolvate.
Acta crystallographica. Section E, Structure reports online 20120401
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2-(4-Isobutyl-phen-yl)-N'-[(3Z)-2-oxoindolin-3-yl-idene]propano-hydrazide.
Acta crystallographica. Section E, Structure reports online 20120401
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Astaxanthin treatment reduced oxidative induced pro-inflammatory cytokines secretion in U937: SHP-1 as a novel biological target.
Marine drugs 20120401
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Aza-oxindole synthesis by oxidative coupling of C(sp2)-H and C(sp3)-H centers.
Chemical communications (Cambridge, England) 20120325
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Palladium-catalyzed amidation by chemoselective C(sp3)-H activation: concise route to oxindoles using a carbamoyl chloride precursor.
Angewandte Chemie (International ed. in English) 20120312
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Asymmetric synthesis of allenyl oxindoles and spirooxindoles by a catalytic enantioselective Saucy-Marbet Claisen rearrangement.
Angewandte Chemie (International ed. in English) 20120305
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N-Heterocyclic carbene-catalyzed three-component domino reaction of alkynyl aldehydes with oxindoles.
Organic letters 20120302
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Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials.
Current topics in medicinal chemistry 20120301
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Induction of activation of the antioxidant response element and stabilization of Nrf2 by 3-(3-pyridylmethylidene)-2-indolinone (PMID) confers protection against oxidative stress-induced cell death.
Toxicology and applied pharmacology 20120301
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5-Fluoro-6'H,7'H,8'H-spiro-[indoline-3,7'-pyrano[3,2-c:5,6-c']di-1-benzopyran]-2,6',8'-trione.
Acta crystallographica. Section E, Structure reports online 20120301
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1-(2-Hy-droxy-eth-yl)-1'-methyl-4'-(naph-thal-en-1-yl)-1'',2'',3'',4''-tetra-hydro-dispiro-[indoline-3,2'-pyrrolidine-3',2''-naphthalene]-2,1''-dione.
Acta crystallographica. Section E, Structure reports online 20120301
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1'-Methyl-4'-phenyl-dispiro-[chromane-3,3'-pyrrolidine-2',3''-indoline]-2,2''-dione.
Acta crystallographica. Section E, Structure reports online 20120301
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Efficient synthesis of multicyclic spirooxindoles via a cascade Michael/Michael/oxa-Michael reaction of curcumins and isatylidene malononitriles.
Organic & biomolecular chemistry 20120227
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First domino radical cyclisation/Smiles rearrangement combination.
Chemical communications (Cambridge, England) 20120227
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Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers.
Chemical communications (Cambridge, England) 20120227
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Facile synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via Brønsted acid catalyzed sp3 C-H functionalization.
Organic letters 20120203
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Diclofenac metabolism in the mouse: novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry.
Xenobiotica; the fate of foreign compounds in biological systems 20120201
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The Arabidopsis concentration-dependent influx/efflux transporter ABCB4 regulates cellular auxin levels in the root epidermis.
The Plant journal : for cell and molecular biology 20120201
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Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations.
Journal of molecular graphics & modelling 20120201
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Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions.
Molecular diversity 20120201
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Protein tyrosine phosphatase inhibitors: a patent review (2002 - 2011).
Expert opinion on therapeutic patents 20120201
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2'-Hy-droxy-methyl-1'-(4-methyl-phen-yl)-2'-nitro-1',2',5',6',7',7a'-hexa-hydro-spiro-[indoline-3,3'-pyrrolizin]-2-one.
Acta crystallographica. Section E, Structure reports online 20120201
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1'-Methyl-4'-phenyl-2''-sulfanylidene-dispiro-[indoline-3,2'-pyrrolidine-3',5''-1,3-thia-zolidine]-2,4''-dione.
Acta crystallographica. Section E, Structure reports online 20120201
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Indolinones as promising scaffold as kinase inhibitors: a review.
Mini reviews in medicinal chemistry 20120201
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Core-structure-oriented asymmetric organocatalytic substitution of 3-hydroxyoxindoles: application in the enantioselective total synthesis of (+)-folicanthine.
Angewandte Chemie (International ed. in English) 20120123
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Dioxindole in asymmetric catalytic synthesis: routes to enantioenriched 3-substituted 3-hydroxyoxindoles and the preparation of maremycin A.
Angewandte Chemie (International ed. in English) 20120123
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Synthesis of oxindoles via visible light photoredox catalysis.
Organic & biomolecular chemistry 20120121
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Highly efficient and stereoselective construction of dispiro-[oxazolidine-2-thione]bisoxindoles and dispiro[imidazolidine-2-thione]bisoxindoles.
Organic letters 20120120
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Asymmetric hydroxyamination of oxindoles catalyzed by chiral bifunctional tertiary amine thiourea: construction of 3-amino-2-oxindoles with quaternary stereocenters.
Organic & biomolecular chemistry 20120114
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Enantioselective organocatalytic oxyamination of unprotected 3-substituted oxindoles.
Organic & biomolecular chemistry 20120114
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Synthesis of highly functionalized chiral 3,3'-disubstituted oxindoles via an organocatalytic enantioselective Michael addition of nitroalkanes to indolylidenecyanoacetates.
Organic letters 20120106
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HPLC analysis of oxindole alkaloids in Uncaria tomentosa: sample preparation and analysis optimisation by factorial design.
Phytochemical analysis : PCA 20120101
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Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial.
Evidence-based complementary and alternative medicine : eCAM 20120101
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Synthesis and anticancer activity of Indolin-2-one derivatives bearing the 4-thiazolidinone moiety.
Archiv der Pharmazie 20120101
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Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.
Autophagy 20120101
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Comparative study of fourteen alkaloids from Uncaria rhynchophylla hooks and leaves using HPLC-diode array detection-atmospheric pressure chemical ionization/MS method.
Chemical & pharmaceutical bulletin 20120101
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1'-Methyl-4'-(4-methyl-phen-yl)dispiro-[1-benzopyran-3(4H),3'-pyrrolidine-2',3''-indoline]-2,2''-dione.
Acta crystallographica. Section E, Structure reports online 20120101
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Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells.
International journal of nanomedicine 20120101
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Synthesis of a dual functional anti-MDR tumor agent PH II-7 with elucidations of anti-tumor effects and mechanisms.
PloS one 20120101
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Carcinogenic effects of N-nitroso-3-(substituted phenylimino)-indolin-2-one derivatives.
Journal of pharmacy & bioallied sciences 20120101
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Violacein induces death of resistant leukaemia cells via kinome reprogramming, endoplasmic reticulum stress and Golgi apparatus collapse.
PloS one 20120101
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Ethylene in organic synthesis: a new route to anticholenergic pyrrolidinoindolines, and other molecules with all carbon-quaternary centers via asymmetric hydrovinylation.
Organic letters 20111216
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Catalytic asymmetric construction of spirocyclopentaneoxindoles by a combined Ru-catalyzed cross-metathesis/double Michael addition sequence.
Organic letters 20111202
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Highly enantioselective one-pot synthesis of spirocyclopentaneoxindoles containing the oxime group by organocatalyzed Michael addition/ISOC/fragmentation sequence.
Organic letters 20111202
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Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.
European journal of medicinal chemistry 20111201
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Binding of oxindole-Schiff base copper(II) complexes to DNA and its modulation by the ligand.
Journal of inorganic biochemistry 20111201
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1',6-Dimethyl-4'-phenyl-dispiro-[1-benzopyran-3(4H),3'-pyrrolidine-2',3''-indoline]-2,2''-dione.
Acta crystallographica. Section E, Structure reports online 20111201
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V2 receptor antagonist; tolvaptan.
Electrolyte & blood pressure : E & BP 20111201
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Pericyclic cascade with chirality transfer: reaction pathway and origin of enantioselectivity of the hetero-Claisen approach to oxindoles.
Angewandte Chemie (International ed. in English) 20111125
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Polarized IR spectra of the hydrogen bond in two different oxindole polymorphs with cyclic dimers in their lattices.
The journal of physical chemistry. A 20111110
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Synthesis and biological evaluation of 3-substituted-indolin-2-one derivatives containing chloropyrrole moieties.
Molecules (Basel, Switzerland) 20111108
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Indolin-2-one p38α inhibitors III: bioisosteric amide replacement.
Bioorganic & medicinal chemistry letters 20111101
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1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study.
European journal of medicinal chemistry 20111101
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(E)-3-(1-Phenyl-ethyl-idene)indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20111101
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1,3,3-Tribenzyl-indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20111101
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Trifluoroacetic acid-promoted synthesis of 3-hydroxy, 3-amino and spirooxindoles from α-keto-N-anilides.
Organic letters 20111021
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Diastereo- and enantioselective conjugate addition of 3-substituted oxindoles to nitroolefins catalyzed by a chiral Ni(OAc)2-diamine complex under mild conditions.
Organic letters 20111007
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Receptor-based QSAR study for a series of 3,3-disubstituted-5-aryl oxindoles and 6-aryl benzimidazol-2-ones derivatives as progesterone receptor inhibitors.
SAR and QSAR in environmental research 20111001
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Catalytic enantioselective total synthesis of hodgkinsine B.
Angewandte Chemie (International ed. in English) 20110919
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Enantioselective Michael/cyclization reaction sequence: scaffold-inspired synthesis of spirooxindoles with multiple stereocenters.
Angewandte Chemie (International ed. in English) 20110919
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Chiral counteranion synergistic organocatalysis under high temperature: efficient construction of optically pure spiro[cyclohexanone-oxindole] backbone.
Organic letters 20110916
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Indolin-2-one p38α inhibitors II: Lead optimisation.
Bioorganic & medicinal chemistry letters 20110915
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Synthesis and structure-activity relationships of constrained heterocyclic analogues of combretastatin A4.
ChemMedChem 20110905
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Ultrasound promoted clay catalyzed efficient and one pot synthesis of substituted oxindoles.
Ultrasonics sonochemistry 20110901
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Violacein and related tryptophan metabolites produced by Chromobacterium violaceum: biosynthetic mechanism and pathway for construction of violacein core.
Applied microbiology and biotechnology 20110901
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Ligand polarizability contributes to tau fibril binding affinity.
Bioorganic & medicinal chemistry 20110901
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Spiro-[cyclo-propane-1,3'-indolin]-2'-one.
Acta crystallographica. Section E, Structure reports online 20110901
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Asymmetric decarboxylative allylation of oxindoles.
Organic letters 20110819
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Addition of TMSCN to chiral ketimines derived from isatin. Synthesis of an oxindole-based peptidomimetic and a bioactive spirohydantoin.
Organic & biomolecular chemistry 20110807
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Rauniticine-allo-oxindole B and rauniticinic-allo acid B, new heteroyohimbine-type oxindole alkaloids from the stems of Malaysian Uncaria longiflora var. pteropoda.
Molecules (Basel, Switzerland) 20110804
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Design, synthesis and biological evaluation of novel 4-thiazolidinones containing indolin-2-one moiety as potential antitumor agent.
European journal of medicinal chemistry 20110801
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3-(Diphenyl-methyl-idene)indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20110801
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Indolin-2-one p38α inhibitors I: design, profiling and crystallographic binding mode.
Bioorganic & medicinal chemistry letters 20110715
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Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed α-arylation/alkylation sequence.
Angewandte Chemie (International ed. in English) 20110704
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Novel small molecule drugs inhibit tumor cell metabolism and show potent anti-tumorigenic potential.
Cancer chemotherapy and pharmacology 20110701
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Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di(indolyl)indolin-2-ones.
Bioorganic & medicinal chemistry letters 20110701
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The Knoevenagel product of indolin-2-one and ferrocene-1,1'-dicarbaldehyde.
Acta crystallographica. Section C, Crystal structure communications 20110701
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Thyroidology over the ages.
Indian journal of endocrinology and metabolism 20110701
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Syntheses of spirocyclic oxindole-butenolides by using three-component cycloadditions of isocyanides, allenoates, and isatins.
Chemistry (Weinheim an der Bergstrasse, Germany) 20110627
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Irreversible Nek2 kinase inhibitors with cellular activity.
Journal of medicinal chemistry 20110623
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Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea.
Chemical communications (Cambridge, England) 20110621
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Directed oxidative cyclizations to C2- or C4-positions of indole: efficient construction of the bicyclo[4.3.1]decane core of welwitindolinones.
Organic letters 20110617
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Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain.
Bioorganic & medicinal chemistry letters 20110615
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Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 20110615
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Electron density of two bioactive oligocyclic indole and oxindole derivatives obtained from low-order X-ray data and invariom application.
Chemistry, an Asian journal 20110606
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Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines.
European journal of medicinal chemistry 20110601
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Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst.
Nature chemistry 20110601
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Tris(3-hy-droxy-imino-1-methyl-indolin-2-one) monohydrate.
Acta crystallographica. Section E, Structure reports online 20110601
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Facile creation of 2-substituted indolin-3-ones by using primary-secondary diamine catalysts.
Chemistry (Weinheim an der Bergstrasse, Germany) 20110523
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Chiral capillary electrophoresis-mass spectrometry of tetrahydroisoquinoline-derived neurotoxins: observation of complex stereoisomerism.
Journal of chromatography. A 20110520
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Amino-indanol-catalyzed asymmetric Michael additions of oxindoles to protected 2-amino-1-nitroethenes for the synthesis of 3,3'-disubstituted oxindoles bearing α,β-diamino functionality.
The Journal of organic chemistry 20110520
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Synthesis and antitumor activity of 5-[1-(3-(dimethylamino)propyl)-5-halogenated-2-oxoindolin-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamides.
Bioorganic & medicinal chemistry letters 20110515
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Iodo-carbocyclization of electron-deficient alkenes: synthesis of oxindoles and spirooxindoles.
Organic letters 20110506
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Dynamic 1H NMR study around the carbon-carbon single bond and partial carbon-carbon double bond in the two particular phosphorus ylides and in an enaminoester.
Magnetic resonance in chemistry : MRC 20110501
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Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors.
Oncotarget 20110501
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A [3+2] dipolar cycloaddition route to 3-hydroxy-3-alkyl oxindoles: an approach to pyrrolidinoindoline alkaloids.
Organic letters 20110415
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Highly enantioselective synthesis of α,α-dialkylmalonates by phase-transfer catalytic desymmetrization.
Journal of the American Chemical Society 20110406
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Core-structure-motivated design of a phosphine-catalyzed [3+2] cycloaddition reaction: enantioselective syntheses of spirocyclopenteneoxindoles.
Journal of the American Chemical Society 20110406
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Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring.
European journal of medicinal chemistry 20110401
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Flexible strategy for syntheses of spirooxindoles using palladium-catalyzed carbosilylation and Sakurai-type cyclization.
Organic letters 20110401
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SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants.
PLoS pathogens 20110401
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1',1''-Dimethyl-4'-(naphthalen-1-yl)-1,2,3,4-tetra-hydro-naphthalene-2-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-1,2''-dione.
Acta crystallographica. Section E, Structure reports online 20110401
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Stir bar sorptive extraction of diclofenac from liquid formulations: a proof of concept study.
Journal of pharmaceutical and biomedical analysis 20110325
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Catalytic asymmetric 1,3-dipolar cycloaddition of N-unprotected 2-oxoindolin-3-ylidene derivatives and azomethine ylides for the construction of spirooxindole-pyrrolidines.
Organic & biomolecular chemistry 20110321
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Chiral calcium VAPOL phosphate mediated asymmetric chlorination and Michael reactions of 3-substituted oxindoles.
Journal of the American Chemical Society 20110316
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Oxindole derivatives as inhibitors of TAK1 kinase.
Bioorganic & medicinal chemistry letters 20110315
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Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design.
Antiviral chemistry & chemotherapy 20110307
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Catalytic thia-Sommelet-Hauser rearrangement: application to the synthesis of oxindoles.
Organic letters 20110304
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Molybdenum-catalyzed asymmetric allylic alkylation of 3-alkyloxindoles: reaction development and applications.
Chemistry (Weinheim an der Bergstrasse, Germany) 20110301
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Organocatalytic Michael-alkylation cascade: the enantioselective nitrocyclopropanation of oxindoles.
Chemistry (Weinheim an der Bergstrasse, Germany) 20110301
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Highly enantioselective catalytic benzoyloxylation of 3-aryloxindoles using chiral VAPOL calcium phosphate.
Angewandte Chemie (International ed. in English) 20110201
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Different biochemical correlates for different neuropsychiatric abnormalities in patients with cirrhosis.
Hepatology (Baltimore, Md.) 20110201
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rac-(rel-1R,2R,4S)-Spiro-[bicyclo-[2.2.1]heptane-2,3'-indol]-2'-amine.
Acta crystallographica. Section E, Structure reports online 20110201
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Dimethyl 2-(1-benzyl-2-oxoindolin-3-yl-idene)-1,3-dithiole-4,5-dicarboxyl-ate.
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Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.
Journal of natural products 20110128
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Enantioselective Morita-Baylis-Hillman reaction of isatins with acrylates: facile creation of 3-hydroxy-2-oxindoles.
Organic letters 20110107
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Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System.
Evidence-based complementary and alternative medicine : eCAM 20110101
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Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as β-amyloid aggregation inhibitors.
European journal of medicinal chemistry 20110101
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Structure-based drug design and AutoDock study of potential protein tyrosine kinase inhibitors.
Bioinformation 20110101
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(E)-1,1'-Dibutyl-3,3'-biindolinyl-idene-2,2'-dione.
Acta crystallographica. Section E, Structure reports online 20110101
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Recent advances in molecular diagnosis of thyroid cancer.
Journal of thyroid research 20110101
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Combined 3D-QSAR modeling and molecular docking studies on pyrrole-indolin-2-ones as Aurora A kinase inhibitors.
International journal of molecular sciences 20110101
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Medullary thyroid carcinoma: molecular signaling pathways and emerging therapies.
Journal of thyroid research 20110101
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How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer.
Journal of thyroid research 20110101
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Indole alkaloids from Aspidosperma rigidum and A. schultesii and their antiparasitic effects.
Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101
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Differential inhibitor sensitivity between human kinases VRK1 and VRK2.
PloS one 20110101
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Investigation of the structure requirement for 5-HT₆ binding affinity of arylsulfonyl derivatives: a computational study.
International journal of molecular sciences 20110101
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Combined 3D-QSAR and docking modelling study on indolocarbazole series compounds as Tie-2 inhibitors.
International journal of molecular sciences 20110101
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Investigation on quantitative structure activity relationships and pharmacophore modeling of a series of mGluR2 antagonists.
International journal of molecular sciences 20110101
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A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates.
Scientia pharmaceutica 20110101
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The importance of being profiled: improving drug candidate safety and efficacy using ion channel profiling.
Frontiers in pharmacology 20110101
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In silico identification of structure requirement for novel thiazole and oxazole derivatives as potent fructose 1,6-bisphosphatase inhibitors.
International journal of molecular sciences 20110101
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New antiangiogenics in non-small cell lung cancer treatment: Vargatef™ (BIBF 1120) and beyond.
Therapeutics and clinical risk management 20110101
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Structural requirements of N-substituted spiropiperidine analogues as agonists of nociceptin/orphanin FQ receptor.
International journal of molecular sciences 20110101
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Molecular-field-based three-dimensional similarity studies on quinoline-based CNS active agents.
ISRN pharmaceutics 20110101
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Synthesis, antimicrobial and antioxidant activity of some oxindoles.
Indian journal of pharmaceutical sciences 20110101
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Asymmetric conjugate addition of oxindoles to 2-chloroacrylonitrile: a highly effective organocatalytic strategy for simultaneous construction of 1,3-nonadjacent stereocenters leading to chiral pyrroloindolines.
Chemistry (Weinheim an der Bergstrasse, Germany) 20101227
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Highly enantioselective organocatalytic α-amination reactions of aryl oxindoles: developing designer multifunctional alkaloid catalysts.
Organic letters 20101217
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Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.
Bioorganic & medicinal chemistry letters 20101215
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Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition.
Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201
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A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation.
European journal of medicinal chemistry 20101201
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3-[2-(1H-Benzimidazol-2-ylsulfan-yl)eth-yl]-1,3-oxazolidin-2-one.
Acta crystallographica. Section E, Structure reports online 20101201
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Novel potent orally active multitargeted receptor tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of 2-indolinone derivatives.
Journal of medicinal chemistry 20101125
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A myosin V inhibitor based on privileged chemical scaffolds.
Angewandte Chemie (International ed. in English) 20101102
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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3'-Hy-droxy-methyl-1'-methyl-3'-nitro-4'-(o-tol-yl)spiro-[indoline-3,2'-pyrrolidin]-2-one.
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Palladium-catalyzed carbo-heterofunctionalization of alkenes for the synthesis of oxindoles and spirooxindoles.
Organic letters 20101015
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Palladium-catalyzed tandem diperoxidation/C-H activation resulting in diperoxy-oxindole in air.
Organic letters 20101015
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Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones.
Journal of medicinal chemistry 20101014
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Stereocontrolled creation of all-carbon quaternary stereocenters by organocatalytic conjugate addition of oxindoles to vinyl sulfone.
Angewandte Chemie (International ed. in English) 20101011
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Organocatalytic and electrophilic approach to oxindoles with C3-quaternary stereocenters.
Organic letters 20101001
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4-(3-Fluoro-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide.
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Methyl 3-[(1H-benzimidazol-1-yl)meth-yl]-1-methyl-4-(4-methyl-phen-yl)-2'-oxopyrrolidine-2-spiro-3'-1-benzimidazole-3-carboxyl-ate.
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5,6-Dimeth-oxy-4',5'-diphenyl-indane-2-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-1,2''-dione.
Acta crystallographica. Section E, Structure reports online 20101001
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Copper-catalyzed asymmetric addition of arylboronates to isatins: a catalytic cycle involving alkoxocopper intermediates.
Chemical communications (Cambridge, England) 20100928
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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.
Bioorganic & medicinal chemistry letters 20100915
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A facile method for the synthesis of oxindole based quaternary alpha-aminonitriles via the Strecker reaction.
Organic & biomolecular chemistry 20100907
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Synthesis of selenophene derivatives as novel CHK1 inhibitors.
Bioorganic & medicinal chemistry letters 20100901
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1-(2-Oxoindolin-3-yl-idene)-4-[2-(tri-fluoro-meth-yl)phen-yl]thio-semicarbazide.
Acta crystallographica. Section E, Structure reports online 20100901
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1-(2-Oxoindolin-3-yl-idene)-4-[2-(trifluoro-meth-oxy)phen-yl]thio-semi-carbazide.
Acta crystallographica. Section E, Structure reports online 20100901
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5'-Amino-2-oxo-2',3'-dihydro-spiro-[indoline-3,7'-thieno[3,2-b]pyran]-6'-carbonitrile 1',1'-dioxide.
Acta crystallographica. Section E, Structure reports online 20100901
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3-[2-(5H-Indolo[2,3-b]quinoxalin-5-yl)eth-yl]-1,3-oxazolidin-2-one.
Acta crystallographica. Section E, Structure reports online 20100901
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Synthesis, electrochemical studies and anticancer activity of ferrocenyl oxindoles.
Dalton transactions (Cambridge, England : 2003) 20100821
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Branch-selective synthesis of oxindole and indene scaffolds: transition metal-controlled intramolecular aryl amidation leading to c3 reverse-prenylated oxindoles.
Organic letters 20100820
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Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B.
Angewandte Chemie (International ed. in English) 20100809
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First C-H activation route to oxindoles using copper catalysis.
Organic letters 20100806
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Oxidative protein labeling in mass-spectrometry-based proteomics.
Analytical and bioanalytical chemistry 20100801
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Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.
Bioorganic & medicinal chemistry letters 20100801
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N'-(1-Allyl-2-oxoindolin-3-yl-idene)benzohydrazide.
Acta crystallographica. Section E, Structure reports online 20100801
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2-Chloro-N-isopropyl-N-phenyl-acetamide.
Acta crystallographica. Section E, Structure reports online 20100801
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Highly enantioselective construction of spiro[4H-pyran-3,3'-oxindoles] through a domino Knoevenagel/Michael/cyclization sequence catalyzed by cupreine.
Organic letters 20100716
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Organocatalytic enantioselective hydroxymethylation of oxindoles with paraformaldehyde as C1 unit.
The Journal of organic chemistry 20100716
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Highly diastereo- and enantioselective Michael additions of 3-substituted oxindoles to maleimides catalyzed by chiral bifunctional thiourea-tertiary amine.
Organic letters 20100702
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Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors.
Bioorganic & medicinal chemistry 20100701
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4-(2-Ethyl-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide.
Acta crystallographica. Section E, Structure reports online 20100701
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(Z)-2-(2-Isopropyl-5-methyl-phen-oxy)-N'-(2-oxoindolin-3-yl-idene)acetohydrazide.
Acta crystallographica. Section E, Structure reports online 20100701
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4-(3-Iodo-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide.
Acta crystallographica. Section E, Structure reports online 20100701
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1-[2-Oxo-5-(trifluoro-meth-oxy)indolin-3-yl-idene]-4-[4-(trifluoro-methyl)-phen-yl]thio-semicarbazide.
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Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins.
Organic & biomolecular chemistry 20100628
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Highly enantioselective synthesis of 3-amino-2-oxindole derivatives: catalytic asymmetric alpha-amination of 3-substituted 2-oxindoles with a chiral scandium complex.
Chemistry (Weinheim an der Bergstrasse, Germany) 20100611
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Oxidative dearomatization in the synthesis of erythrina, oxindole and hexahydropyrrolo[2,3-b]indole skeletons.
Chemical communications (Cambridge, England) 20100607
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Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to spiro[pyrrolidine-3,3'-oxindoles]. Total synthesis of (+/-)-coerulescine, (+/-)-horsfiline, (+/-)-elacomine, and (+/-)-6-deoxyelacomine.
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Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy.
The American journal of gastroenterology 20100601
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Xanthine oxidase/tyrosinase inhibiting, antioxidant, and antifungal oxindole alkaloids from Isatis costata.
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4-(3-Methoxy-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide.
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4-(3-Nitro-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide.
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(E,Z)-3-(3',5'-Dimethoxy-4'-hydroxy-benzylidene)-2-indolinone blocks mast cell degranulation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100512
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Synthesis of notoamide J: a potentially pivotal intermediate in the biosynthesis of several prenylated indole alkaloids.
The Journal of organic chemistry 20100507
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Six-component reactions for the stereoselective synthesis of 3-arylidene-2-oxindoles via sequential one-pot Ugi/Heck carbocyclization/Sonogashira/nucleophilic addition.
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Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer.
The oncologist 20100501
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4-(2-Fluoro-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide.
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4-(5-Chloro-2-methyl-phen-yl)-1-[2-oxo-5-(trifluoro-meth-oxy)indolin-3-yl-idene]thio-semicarbazide.
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Dimeric quinidine-catalyzed enantioselective aminooxygenation of oxindoles: an organocatalytic approach to 3-hydroxyoxindole derivatives.
Journal of the American Chemical Society 20100428
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An efficient stereoselective synthesis of 3-spirocyclopentene- and 3-spiropyrazole-2-oxindoles via 1,3-dipolar cycloaddition reaction.
Chemical communications (Cambridge, England) 20100428
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Evolution of a strategy for total synthesis of the marine fungal alkaloid (+/-)-communesin F.
The Journal of organic chemistry 20100416
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Oxindole synthesis by palladium-catalysed aromatic C-H alkenylation.
Chemical communications (Cambridge, England) 20100414
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Catalytic asymmetric synthesis of 3-(alpha-hydroxy-beta-carbonyl) oxindoles by a Sc(III)-catalyzed direct aldol-type reaction.
Chemistry (Weinheim an der Bergstrasse, Germany) 20100322
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Highly enantioselective intramolecular cyanoamidation: (+)-horsfiline, (-)-coerulescine, and (-)-esermethole.
Organic letters 20100305
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Predictive comparative QSAR modelling of (phenylpiperazinyl-alkyl) oxindoles as selective 5-HT1A antagonists by stepwise regression, PCRA, FA-MLR and PLS techniques.
European journal of medicinal chemistry 20100301
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Organocatalytic tandem reaction to construct six-membered spirocyclic oxindoles with multiple chiral centres through a formal [2+2+2] annulation.
Chemistry (Weinheim an der Bergstrasse, Germany) 20100301
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4'-(2,4-Dichloro-phen-yl)-1,1'-dimethyl-piperidine-3-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-4,2''-dione.
Acta crystallographica. Section E, Structure reports online 20100301
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Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.
Bioorganic & medicinal chemistry 20100215
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Catalytic asymmetric synthesis of 3-aminooxindoles: enantiofacial selectivity switch in bimetallic vs monometallic Schiff base catalysis.
Journal of the American Chemical Society 20100203
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Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib.
Acta crystallographica. Section C, Crystal structure communications 20100201
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5-Chloro-benzothia-zole-2-spiro-3'-indolin-2'-one.
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Asymmetric Michael addition reaction of 3-substituted-N-Boc oxindoles to activated terminal alkenes catalyzed by a bifunctional tertiary-amine thiourea catalyst.
Organic & biomolecular chemistry 20100107
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Catalytic double stereoinduction in asymmetric allylic alkylation of oxindoles.
Chemistry (Weinheim an der Bergstrasse, Germany) 20100104
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Catalytic asymmetric synthesis of substituted 3-hydroxy-2-oxindoles.
Angewandte Chemie (International ed. in English) 20100101
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Thyroid cancer: current molecular perspectives.
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Covalent anchoring of chloroperoxidase and glucose oxidase on the mesoporous molecular sieve SBA-15.
International journal of molecular sciences 20100101
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Metabolism of isorhynchophylline in rats detected by LC-MS.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101
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New targeted molecular therapies for dedifferentiated thyroid cancer.
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Ethnomedicine of the Kagera Region, north western Tanzania. Part 2: The medicinal plants used in Katoro Ward, Bukoba District.
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Efficacy of c-Met inhibitor for advanced prostate cancer.
BMC cancer 20100101
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Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line.
Molecular cancer 20100101
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Enantioselective synthesis of substituted oxindoles and spirooxindoles with applications in drug discovery.
Current opinion in drug discovery & development 20100101
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Total synthesis of (±)-coerulescine and (±)-horsfiline.
Beilstein journal of organic chemistry 20100101
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Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.
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Synthesis and evaluation of 1,3 di-substituted schiff, mannich bases and spiro isatin derivatives.
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1'-Benzyl-4,4''-bis-(4-chloro-phen-yl)-3-(2,6-dichloro-phen-yl)-1''-methyl-4,5-dihydro-isoxazole-5-spiro-3'-piperidine-5'-spiro-3''-pyrrolidine-2''-spiro-3'''-indoline-2''',4'-dione.
Acta crystallographica. Section E, Structure reports online 20100101
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1'-Methyl-2-oxo-5'-phenyl-spiro-[indoline-3,3'-pyrrolidine]-4',4'-dicarbo-nitrile.
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The genus Gelsemium: An update.
Pharmacognosy reviews 20100101
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Synthesis, characterization, and analgesic activity of novel schiff base of isatin derivatives.
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[Anticancer effects of a novel indolinone compound in nasopharyngeal carcinoma cells].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20091218
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Expanding the scope of cinchona alkaloid-catalyzed enantioselective alpha-aminations of oxindoles: a versatile approach to optically active 3-amino-2-oxindole derivatives.
The Journal of organic chemistry 20091204
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Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells.
Molecular and cellular neurosciences 20091201
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Violacein-producing Collimonas sp. from the sea surface microlayer of costal waters in Trøndelag, Norway.
Marine drugs 20091201
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Asymmetric construction of quaternary stereocenters by direct organocatalytic amination of 3-substituted oxindoles.
Chemical communications (Cambridge, England) 20091128
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Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor.
Bioorganic & medicinal chemistry 20091115
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3-Hydr-oxy-3-nitro-methyl-indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20091101
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Functionalization and rearrangement of spirocyclohexadienyl oxindoles: experimental and theoretical investigations.
Chemistry (Weinheim an der Bergstrasse, Germany) 20091026
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Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation.
Biochemical pharmacology 20091015
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Oxindole-Schiff base copper(II) complexes interactions with human serum albumin: spectroscopic, oxidative damage, and computational studies.
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Diethyl 1-acetyl-4'-(4-chloro-phen-yl)-5'-(4-nitro-phen-yl)-2-oxospiro-[indoline-3,3'-pyrrolidine]-2',2'-dicarboxyl-ate.
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Organocatalytic synthesis of spiro[pyrrolidin-3,3'-oxindoles] with high enantiopurity and structural diversity.
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Securin promotes the identification of favourable outcome in invasive breast cancer.
British journal of cancer 20090915
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Selective synthesis of 3-aryl quinolin-2(1H)-ones and 3-(1-arylmethylene)oxindoles involving a 2-fold arene C-H activation process.
The Journal of organic chemistry 20090904
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Highly enantioselective and organocatalytic alpha-amination of 2-oxindoles.
Organic letters 20090903
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Access to a welwitindolinone core using sequential cycloadditions.
Organic letters 20090820
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Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential.
Bioorganic & medicinal chemistry letters 20090815
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Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations.
Organic letters 20090806
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Stereocontrolled synthesis of spirooxindoles through Lewis acid-promoted [5 + 2]-annulation of chiral silyl alcohols.
Organic letters 20090806
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Antioxidant potential study of some synthesized N-heterocycles.
Bangladesh Medical Research Council bulletin 20090801
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Palladium-catalyzed enantioselective alpha-arylation and alpha-vinylation of oxindoles facilitated by an axially chiral P-stereogenic ligand.
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Direct N-carbamoylation of 3-monosubstituted oxindoles with alkyl imidazole carboxylates.
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Organocatalytic asymmetric allylic alkylation of oxindoles with Morita-Baylis-Hillman carbonates.
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A homodinuclear Mn(III)2-Schiff base complex for catalytic asymmetric 1,4-additions of oxindoles to nitroalkenes.
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Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: application to the formal synthesis of (+)-physostigmine.
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5-Bromo-1-methyl-indolin-2-one.
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4'-(4-Methoxy-phen-yl)-1,1',1''-trimethyl-dispiro-[indoline-3,2'-pyrrolidine-3',3''-pyrrolidine]-2,2'',5''-trione.
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Reactions of ortho-lithiophenyl (-hetaryl) isocyanides with carbonyl compounds: rearrangements of 2-metalated 4H-3,1-benzoxazines.
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Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich tyrosine kinase 2 (PYK2) inhibitors: retrospective analysis by CYP3A4 molecular docking, quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry.
Bioorganic & medicinal chemistry letters 20090615
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Oxindole synthesis by direct C-H, Ar-H coupling.
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Concise synthesis of the bicyclic scaffold of N-methylwelwitindolinone C isothiocyanate via an indolyne cyclization.
Organic letters 20090604
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Four tetracyclic oxindole alkaloids and a taberpsychine derivative from a Malayan Tabernaemontana.
Phytochemistry 20090601
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Enantioselective synthesis of SM-130686 based on the development of asymmetric Cu(I)F catalysis to access 2-oxindoles containing a tetrasubstituted carbon.
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Stereoselective oxindole synthesis by palladium-catalyzed cyclization reaction of 2-(alkynyl)aryl isocyanates with amides.
Organic letters 20090521
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Ruthenium-catalyzed alkylation of oxindole with alcohols.
The Journal of organic chemistry 20090515
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3'-Benz-yloxy-3-hydr-oxy-3,3'-bi-1H-indole-2,2'(3H,3'H)-dione monohydrate.
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Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.
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Ugi-post functionalization, from a single set of ugi-adducts to two distinct heterocycles by microwave-assisted palladium-catalyzed cyclizations: tuning the reaction pathways by ligand switch.
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Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics.
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Ghrelin receptor modulators and their therapeutic potential.
Future medicinal chemistry 20090401
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Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line.
European journal of medicinal chemistry 20090301
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Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity.
Bioorganic & medicinal chemistry 20090301
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Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones.
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Enantioselective formal synthesis of (+)-dihydrocorynantheine and (-)-dihydrocorynantheol.
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Synthesis of oxindoles by tandem Heck-reduction-cyclization (HRC) from a single bifunctional, in situ generated Pd/C catalyst.
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AcOLeDMAP and BnOLeDMAP: conformationally restricted nucleophilic catalysts for enantioselective rearrangement of indolyl acetates and carbonates.
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Effect of Alkaloid-Free and Alkaloid-Rich preparations from Uncaria tomentosa bark on mitotic activity and chromosome morphology evaluated by Allium Test.
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Structure-based CoMFA and CoMSIA study of indolinone inhibitors of PDK1.
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Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.
Molecular pharmacology 20090101
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The discovery of highly potent CGRP receptor antagonists.
Bioorganic & medicinal chemistry letters 20090101
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Oxindole synthesis by direct coupling of C(sp2)-H and C(sp3)-H centers.
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Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays.
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Angewandte Chemie (International ed. in English) 20090101
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Catalytic enantioselective stereoablative alkylation of 3-halooxindoles: facile access to oxindoles with C3 all-carbon quaternary stereocenters.
Angewandte Chemie (International ed. in English) 20090101
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A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication.
BMC microbiology 20090101
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Sunitinib: a multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20090101
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6-Bromo-1-butylindoline-2,3-dione.
Acta crystallographica. Section E, Structure reports online 20090101
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1-Benzyl-4',5'-diphenyl-piperidine-3-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-4,2''-dione.
Acta crystallographica. Section E, Structure reports online 20090101
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(Z)-5-Fluoro-3-[(1H-pyrrol-2-yl)methyl-ene]indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20090101
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Catalytic enantioselective Meerwein-Eschenmoser Claisen rearrangement: asymmetric synthesis of allyl oxindoles.
Journal of the American Chemical Society 20081203
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Stereoselective synthesis of 3-alkylideneoxindoles by palladium-catalyzed cyclization reaction of 2-(alkynyl)aryl isocyanates with organoboron reagents.
Organic letters 20081106
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Blood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib.
British journal of cancer 20081104
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Synthesis and biological evaluation of diversely substituted indolin-2-ones.
European journal of medicinal chemistry 20081101
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Benzoxazinoid biosynthesis in dicot plants.
Phytochemistry 20081101
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(13)C, (15)N CPMAS NMR and GIAO DFT calculations of stereoisomeric oxindole alkaloids from Cat's Claw (Uncaria tomentosa).
Solid state nuclear magnetic resonance 20081101
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(E)-5-Chloro-3-(2,6-dichloro-benzyl-idene)-indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20081101
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Rearrangement of spirocyclic oxindoles with lithium amide bases.
Organic letters 20081016
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Samarium(II)-mediated spirocyclization by intramolecular aryl radical addition onto an aromatic ring.
The Journal of organic chemistry 20080919
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Diazonamide support studies: stereoselective formation of the C10 chiral center in both the CDEFG and AEFG fragments.
Organic letters 20080918
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Stereoselective oxidative rearrangement of 2-aryl tryptamine derivatives.
Organic letters 20080918
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Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
Bioorganic & medicinal chemistry letters 20080915
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Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis.
Chemical communications (Cambridge, England) 20080914
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Combined 3D-QSAR modeling and molecular docking study on indolinone derivatives as inhibitors of 3-phosphoinositide-dependent protein kinase-1.
Journal of chemical information and modeling 20080901
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1',5-Dinitro-2'-phenyl-2',3',5',6',7',7a'-hexa-hydro-spiro-[indoline-3,3'-1'H-pyrrolizin]-2-one.
Acta crystallographica. Section E, Structure reports online 20080901
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Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.
Journal of medicinal chemistry 20080828
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Intermolecular enolate heterocoupling: scope, mechanism, and application.
Journal of the American Chemical Society 20080827
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Organocatalytic stereoselective mannich reaction of 3-substituted oxindoles.
Organic letters 20080821
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Enantioselective synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed cyanoamidation.
Organic letters 20080807
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2'-Methyl-2'-nitro-1'-phenyl-2',3',5',6',7',7a'-hexa-hydro-spiro-[indoline-3,3'-1'H-pyrrolizin]-2-one.
Acta crystallographica. Section E, Structure reports online 20080801
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Orthogonal Pd- and Cu-based catalyst systems for C- and N-arylation of oxindoles.
Journal of the American Chemical Society 20080723
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Palladium-catalyzed C-H functionalization of N-arylpropiolamides with aryliodonium salts: selective synthesis of 3-(1-arylmethylene)oxindoles.
The Journal of organic chemistry 20080718
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Facile and general synthesis of quaternary 3-aminooxindoles.
Organic letters 20080703
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BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.
Cancer research 20080615
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Molecular docking/dynamics studies of Aurora A kinase inhibitors.
Journal of molecular graphics & modelling 20080601
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Synthesis of (2-oxoindolin-3-ylidene)methyl acetates involving a C-H functionalization process.
Organic letters 20080501
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Identification of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays.
Proteomics 20080501
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1-Allyl-3,3-diphenyl-indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20080501
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1-Allyl-3,3-di-p-tolyl-indolin-2-one.
Acta crystallographica. Section E, Structure reports online 20080501
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(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists.
Journal of medicinal chemistry 20080424
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Palladium-catalyzed alpha-arylation of oxindoles.
Organic letters 20080403
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Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).
Journal of medicinal chemistry 20080327
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A new route to indolines by the Cu-catalyzed cyclization reaction of 2-ethynylanilines with sulfonyl azides.
Organic letters 20080320
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Fragment-based de novo ligand design by multiobjective evolutionary optimization.
Journal of chemical information and modeling 20080301
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5'-Chloro-spiro-[1,3-dioxolane-2,3'-indolin]-2'-one: a potential anti-convulsant.
Acta crystallographica. Section E, Structure reports online 20080301
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Structural characterization of an enantiomerically pure amino acid imidazolide and direct formation of the beta-lactam nucleus from an alpha-amino acid.
Organic letters 20080207
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1'-Phenyl-6'-thia-cyclo-heptane-1-spiro-2'-perhydro-pyrrolizine-3'-spiro-3''-indoline-2,2''-dione.
Acta crystallographica. Section E, Structure reports online 20080201
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4'-Amino-2,2''-dioxo-2,2'',3,3''-tetra-hydro-1H-indole-3-spiro-1'-cyclo-pent-3'-ene-2'-spiro-3''-1H-indole-3',5',5'-tricarbonitrile dihydrate.
Acta crystallographica. Section E, Structure reports online 20080201
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1-Aminoindanes as novel motif with potential atypical antipsychotic properties.
Bioorganic & medicinal chemistry letters 20080115
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Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
Journal of medicinal chemistry 20080110
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(2E)-N-(2-iodo-4,6-dimethylphenyl)-2-methylbut-2-enamide.
Acta crystallographica. Section C, Crystal structure communications 20080101
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Double-strand DNA cleavage induced by oxindole-Schiff base copper(II) complexes with potential antitumor activity.
Journal of inorganic biochemistry 20080101
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[Synthesis of 1-furfuryl-indolin-2-one derivatives and preliminary evaluation of their antitumor activities].
Yao xue xue bao = Acta pharmaceutica Sinica 20080101
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Palladium-catalyzed tandem Heck reaction/C-H functionalization--preparation of spiro-indane-oxindoles.
Angewandte Chemie (International ed. in English) 20080101
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Marine biofilm bacteria evade eukaryotic predation by targeted chemical defense.
PloS one 20080101
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Synthesis of dihydrophenanthridines by a sequence of Ugi-4CR and palladium-catalyzed intramolecular C-H functionalization.
Beilstein journal of organic chemistry 20080101
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Design and synthesis of novel oxindoles as potential non-nucleosidic reverse transcriptase inhibitors against HIV.
Nucleic acids symposium series (2004) 20080101
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Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases.
Current chemical genomics 20080101
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Oxindolealanine in age-related human cataracts.
Experimental eye research 20071201
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Mo-catalyzed regio-, diastereo-, and enantioselective allylic alkylation of 3-aryloxindoles.
Journal of the American Chemical Society 20071128
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Potent oxindole based human beta3 adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters 20071115
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Design, synthesis and pharmacological evaluation of HIV-1 reverse transcriptase inhibition of new indolin-2-ones.
Medicinal chemistry (Shariqah (United Arab Emirates)) 20071101
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Enantioselective construction of spirocyclic oxindolic cyclopentanes by palladium-catalyzed trimethylenemethane-[3+2]-cycloaddition.
Journal of the American Chemical Society 20071017
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Synthesis of novel functionalized 3-spiropyrrolizidine and 3-spiropyrrolidine oxindoles from Baylis-Hillman adducts of isatin and heteroaldehydes with azomethine ylides via [3+2]-cycloaddition.
Organic letters 20071011
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The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation.
FEBS letters 20070918
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Substitution and cyclization reactions involving the quasi-antiaromatic 2H-indol-2-one ring system.
Organic letters 20070913
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Hydrodynamic stress induces monoterpenoid oxindole alkaloid accumulation by Uncaria tomentosa (Willd) D. C. cell suspension cultures via oxidative burst.
Biotechnology and bioengineering 20070901
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Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand.
Bioorganic & medicinal chemistry 20070901
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Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.
Bioorganic & medicinal chemistry letters 20070901
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1'-Methylcyclooctane-1-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-2,2''-dione and 1,1'-dimethylpiperidine-3-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-2'',4-dione.
Acta crystallographica. Section C, Crystal structure communications 20070901
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Palladium-catalyzed carbonylative annulation reaction of 2-(1-alkynyl)benzenamines: selective synthesis of 3-(halomethylene)indolin-2-ones.
Organic letters 20070816
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Sunitinib malate.
Cancer chemotherapy and pharmacology 20070801
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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.
Bioorganic & medicinal chemistry letters 20070715
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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.
Bioorganic & medicinal chemistry letters 20070715
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Straightforward stereoselective synthesis of spiro-epoxyoxindoles.
Organic letters 20070426
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Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines.
Phytomedicine : international journal of phytotherapy and phytopharmacology 20070401
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Synthesis and biological evaluation of 3-(substituted-benzylidene)-1,3-dihydro-indolin derivatives as human protein kinase CK2 and p60(c-Src) tyrosine kinase inhibitors.
Biological & pharmaceutical bulletin 20070401
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Polyhydroxylated indolines and oxindoles from C-glycosides via sequential Henry reaction, Michael addition, and reductive amination/amidation.
The Journal of organic chemistry 20070330
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Isatinones A and B, new antifungal oxindole alkaloids from Isatis costata.
Molecules (Basel, Switzerland) 20070206
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Quantification of active principles and pigments in leaf extracts of Isatis tinctoria by HPLC/UV/MS.
Planta medica 20070201
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c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays.
British journal of cancer 20070129
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Acid-promoted cyclization reactions of tetrahydroindolinones. Model studies for possible application in a synthesis of selaginoidine.
The Journal of organic chemistry 20070119
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Structure-activity relationship study of oxindole-based inhibitors of cyclin-dependent kinases based on least-squares support vector machines.
Analytica chimica acta 20070109
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Simple and one-pot protocol for synthesis of indene-spiro-oxindoles involving tandem Prins and Friedel-Crafts reactions.
Organic letters 20070104
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Palladium-catalyzed enantioselective domino heck-cyanation sequence: development and application to the total synthesis of esermethole and physostigmine.
Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
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Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives.
Acta pharmacologica Sinica 20070101
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3D-QSAR CoMFA study on oxindole derivatives as cyclin dependent kinase 1 (CDK1) and cyclin dependent kinase 2 (CDK2) inhibitors.
Medicinal chemistry (Shariqah (United Arab Emirates)) 20070101
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A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles.
Journal of combinatorial chemistry 20070101
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Generation of FGF reporter transgenic zebrafish and their utility in chemical screens.
BMC developmental biology 20070101
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Cinchona-alkaloid-catalyzed enantioselective direct aldol-type reaction of oxindoles with ethyl trifluoropyruvate.
Angewandte Chemie (International ed. in English) 20070101
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Antiangiogenic agents: an update on small molecule VEGFR inhibitors.
Current medicinal chemistry 20070101
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Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain.
Journal of neural transmission. Supplementum 20070101
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Lewis acid-catalyzed enantioselective hydroxylation reactions of oxindoles and beta-keto esters using DBFOX ligand.
Journal of the American Chemical Society 20061227
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In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum.
Biochemistry 20061226
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Enantioselective arylation of 2-methylacetoacetates catalyzed by CuI/trans-4-hydroxy-L-proline at low reaction temperatures.
Journal of the American Chemical Society 20061220
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Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors.
Molecular cancer therapeutics 20061201
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Biophysical characterization of an indolinone inhibitor in the ATP-binding site of DNA gyrase.
Biochemical and biophysical research communications 20061103
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Efficient asymmetric synthesis of novel gastrin receptor antagonist AG-041R via highly stereoselective alkylation of oxindole enolates.
The Journal of organic chemistry 20061027
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Heteroyohimbinoid type oxindole alkaloids from Mitragyna parvifolia.
Phytochemistry 20061001
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Acid-base catalysis of chiral Pd complexes: development of novel catalytic asymmetric reactions and their application to synthesis of drug candidates.
Chemical & pharmaceutical bulletin 20061001
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Paratunamides A-D, oxindole alkaloids from Cinnamodendron axillare.
Journal of natural products 20061001
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An efficient synthesis of a spirocyclic oxindole analogue.
Molecules (Basel, Switzerland) 20060914
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Solid phase approaches to N-heterocycles using a sulfur linker cleaved by SmI2.
The Journal of organic chemistry 20060818
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General strategy for the syntheses of corynanthe, tacaman, and oxindole alkaloids.
The Journal of organic chemistry 20060818
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Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1.
Biochemical pharmacology 20060814
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Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.
Journal of neuroscience research 20060801
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Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
Bioorganic & medicinal chemistry letters 20060701
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Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties.
European journal of medicinal chemistry 20060601
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Palladium asymmetric allylic alkylation of prochiral nucleophiles: horsfiline.
Organic letters 20060511
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Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.
Bioorganic & medicinal chemistry letters 20060415
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Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I.
Bioorganic & medicinal chemistry letters 20060415
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Selective kinase inhibition by exploiting differential pathway sensitivity.
Chemistry & biology 20060401
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Diastereoselection in the formation of spirocyclic oxindoles by the intramolecular Heck reaction.
The Journal of organic chemistry 20060331
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Highly diastereoselective one-pot synthesis of spirocyclic oxindoles through intramolecular Ullmann coupling and Claisen rearrangement.
Angewandte Chemie (International ed. in English) 20060327
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Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups.
Blood 20060301
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Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416.
Toxicology in vitro : an international journal published in association with BIBRA 20060301
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Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
British journal of haematology 20060301
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A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin.
Phytotherapy research : PTR 20060301
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Synthesis and pharmacological profile of an orally-active growth hormone secretagogue, SM-130686.
Combinatorial chemistry & high throughput screening 20060301
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Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells.
Chemical research in toxicology 20060301
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Synthesis of the putative structure of fistulosin using the ruthenium-catalyzed cycloisomerization of diene.
The Journal of organic chemistry 20060203
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A new chemical tool for exploring the physiological function of the PDE2 isozyme.
Bioorganic & medicinal chemistry letters 20060115
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The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta.
BMC complementary and alternative medicine 20060101
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Synthesis and evaluation of antimicrobial and anticonvulsant activities of some new 3-[2- (5-aryl-1,3,4-oxadiazol-2-yl/4-carbethoxymethylthiazol-2-yl) imino-4-thiazolidinon-5-ylidene]-5-substituted/nonsubstituted 1H-indole-2-ones and investigation of their structure-activity relationships.
Arzneimittel-Forschung 20060101
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Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40).
Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101
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Oxindole synthesis through intramolecular nucleophilic addition of vinylpalladiums to aryl isocyanates.
Angewandte Chemie (International ed. in English) 20051202
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In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors.
Bioorganic & medicinal chemistry letters 20051201
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Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor.
Bioorganic & medicinal chemistry letters 20051115
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Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach.
European journal of medicinal chemistry 20051101
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Inflammation 2005 - Seventh World Congress. Highlights I.
IDrugs : the investigational drugs journal 20051001
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Rapid access to the Welwitindolinone alkaloid skeleton by cyclization of indolecarboxaldehyde substituted cyclohexanones.
Organic letters 20050915
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Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review.
Evidence-based complementary and alternative medicine : eCAM 20050901
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Indolin-2-ones with high in vivo efficacy in a model for multiple sclerosis.
Journal of medicinal chemistry 20050825
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Stereoselective synthesis of 3-alkylideneoxindoles via palladium-catalyzed domino reactions.
The Journal of organic chemistry 20050819
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SAR studies of 6-aryl-1,3-dihydrobenzimidazol-2-ones as progesterone receptor antagonists.
Bioorganic & medicinal chemistry letters 20050801
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Catalytic enantioselective fluorination of oxindoles.
Journal of the American Chemical Society 20050727
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Identification of degradation products of diclofenac by electrospray ion trap mass spectrometry.
Journal of pharmaceutical and biomedical analysis 20050715
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Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies.
European journal of pharmacology 20050711
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Scavenging of reactive oxygen species by novel indolin-2-one and indoline-2-thione derivatives.
Biopolymers 20050701
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Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis.
Journal of cellular biochemistry 20050701
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Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Pharmacology, biochemistry, and behavior 20050701
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Nitrated and oxidized products of a single tryptophan residue in human Cu,Zn-superoxide dismutase treated with either peroxynitrite-carbon dioxide or myeloperoxidase-hydrogen peroxide-nitrite.
Journal of biochemistry 20050701
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TiCl4 catalyzed tandem construction of C-C and C-O bonds: a simple and one-pot atom-economical stereoselective synthesis of spiro-oxindoles.
Chemical communications (Cambridge, England) 20050528
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Identification of natural dyes used in works of art by pyrolysis-gas chromatography/mass spectrometry combined with in situ trimethylsilylation.
Analytical and bioanalytical chemistry 20050501
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Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor.
Proteomics 20050401
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Structure-activity relationships of the oxindole growth hormone secretagogues.
Bioorganic & medicinal chemistry letters 20050401
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AG-041R, a novel indoline-2-one derivative, stimulates chondrogenesis in a bipotent chondroprogenitor cell line CL-1.
Osteoarthritis and cartilage 20050401
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A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth.
Molecular cancer therapeutics 20050401
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Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma.
Journal of immunology (Baltimore, Md. : 1950) 20050301
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Indol-2-one intermediates: mechanistic evidence and synthetic utility. Total syntheses of (+/-)-flustramines A and C.
Organic letters 20050217
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An active ingredient of Cat's Claw water extracts identification and efficacy of quinic acid.
Journal of ethnopharmacology 20050115
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HPLC quantification of uncarine D and the anti-plasmodial activity of alkaloids from leaves of Mitragyna inermis (Willd.) O. Kuntze.
Phytochemical analysis : PCA 20050101
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Recent developments on KCNQ potassium channel openers.
Current medicinal chemistry 20050101
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Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis.
Toxicological reviews 20050101
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Genotoxic and cytotoxic studies of beta-sitosterol and pteropodine in mouse.
Journal of biomedicine & biotechnology 20050101
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Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711].
Journal of inflammation (London, England) 20050101
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Palladium-catalyzed asymmetric allylation of prochiral nucleophiles: synthesis of 3-allyl-3-aryl oxindoles.
Angewandte Chemie (International ed. in English) 20041227
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MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo.
International journal of cancer 20041220
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Identification of indigoid dyes in natural organic pigments used in historical art objects by high-performance liquid chromatography coupled to electrospray ionization mass spectrometry.
Journal of mass spectrometry : JMS 20041201
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A Lewis acid-promoted cyclization of ethenetricarboxylate derivative aromatic compounds. Novel syntheses of oxindoles and benzofuranones via Friedel-Crafts intramolecular Michael addition.
Organic & biomolecular chemistry 20041107
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Methanol extracts of Hamelia patens containing oxindole alkaloids relax KCl-induced contraction in rat myometrium.
Biological & pharmaceutical bulletin 20041001
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3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner.
Journal of experimental therapeutics & oncology 20041001
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One-pot homolytic aromatic substitutions/HWE olefinations under microwave conditions for the formation of a small oxindole library.
Organic letters 20040930
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Tissue distribution of molidone in a multidrug overdose.
Journal of analytical toxicology 20040901
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New spirocyclic oxindole synthesis based on a hetero Claisen rearrangement.
Organic letters 20040708
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Electroorganic synthesis using a fluoride ion mediator under ultrasonic irradiation: synthesis of oxindole and 3-oxotetrahydroisoquinoline derivatives.
Organic letters 20040708
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Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinoma.
Journal of the National Cancer Institute 20040707
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Javaniside, a novel DNA cleavage agent from Alangium javanicum having an unusual oxindole skeleton.
Chemical communications (Cambridge, England) 20040521
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Novel pyrrole-containing progesterone receptor modulators.
Bioorganic & medicinal chemistry letters 20040503
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Substituted E-3-(2-Chloro-3-indolylmethylene)1,3-dihydroindol-2-ones with antitumor activity.
Bioorganic & medicinal chemistry 20040301
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Inhibitory activity of indolin-2-one derivatives on compound 48/80-induced histamine release from mast cells.
Die Pharmazie 20040301
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A new series of potent oxindole inhibitors of CDK2.
Bioorganic & medicinal chemistry letters 20040223
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Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles.
Bioorganic & medicinal chemistry letters 20040223
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A holistic passive integrative sampling approach for assessing the presence and potential impacts of waterborne environmental contaminants.
Chemosphere 20040201
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Design and synthesis of aminopropyl tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase.
Bioorganic & medicinal chemistry letters 20040105
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Characterisation of natural indigo and shellfish purple by mass spectrometric techniques.
Rapid communications in mass spectrometry : RCM 20040101
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[Effects of 3-substituted aryl oxindole(PH II-7) on cell cycle of tumor cells].
Yao xue xue bao = Acta pharmaceutica Sinica 20031101
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New oxindole alkaloids and iridoid from Carolina jasmine (Gelsemium sempervirens Ait. f.).
Chemical & pharmaceutical bulletin 20031001
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Mapping the kinase domain of Janus Kinase 3.
Bioorganic & medicinal chemistry letters 20030915
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Inactivation of Ret/Ptc1 oncoprotein and inhibition of papillary thyroid carcinoma cell proliferation by indolinone RPI-1.
Cellular and molecular life sciences : CMLS 20030701
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Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid.
Organic letters 20030612
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Potential inhibitors of angiogenesis. Part I: 3-(imidazol-4(5)-ylmethylene)indolin-2-ones.
Journal of enzyme inhibition and medicinal chemistry 20030601
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SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer.
Molecular cancer therapeutics 20030501
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Synthesis of potent oxindole CDK2 inhibitors.
Bioorganic & medicinal chemistry 20030417
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Enantioselective fluorination mediated by N-fluoroammonium salts of cinchona alkaloids: first enantioselective synthesis of BMS-204352 (MaxiPost).
The Journal of organic chemistry 20030321
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A short diastereoselective synthesis of the putative alkaloid jamtine, using a tandem pummerer/mannich cyclization sequence.
The Journal of organic chemistry 20030207
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AG-041R stimulates cartilage matrix synthesis without promoting terminal differentiation in rat articular chondrocytes.
Osteoarthritis and cartilage 20030201
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Gelsemine: a thought-provoking target for total synthesis.
Angewandte Chemie (International ed. in English) 20030103
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Reactions of the ionized enol tautomer of acetanilide: elimination of HNCO via a novel rearrangement.
European journal of mass spectrometry (Chichester, England) 20030101
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RET/PTC oncoproteins: molecular targets of new drugs.
Tumori 20030101
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Enantiospecific, stereospecific total synthesis of the oxindole alkaloid alstonisine.
Organic letters 20021128
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SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase.
Blood 20021015
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Further insights into the reaction of melatonin with hydroxyl radical.
Bioorganic chemistry 20021001
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Enantioselective total synthesis of quadrigemine C and psycholeine.
Journal of the American Chemical Society 20020807
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Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors.
Blood 20020715
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Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors.
Bioorganic & medicinal chemistry letters 20020617
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Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.
Phytomedicine : international journal of phytotherapy and phytopharmacology 20020501
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Densitometric determination of diclofenac, 1-(2,6-dichlorophenyl)indolin-2-one and indolin-2-one in pharmaceutical preparations and model solutions.
Journal of pharmaceutical and biomedical analysis 20020415
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The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.
Bioorganic & medicinal chemistry letters 20020408
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Rational determination of transfer free energies of small drugs across the water-oil interface.
Journal of medicinal chemistry 20020103
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Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms.
Marine pollution bulletin 20020101
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Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands.
Progress in brain research 20020101
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Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents.
Angiogenesis 20020101
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Oxindole derivatives as orally active potent growth hormone secretagogues.
Journal of medicinal chemistry 20011220
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Azomethine ylide cycloaddition/reductive heterocyclization approach to oxindole alkaloids: asymmetric synthesis of (-)-horsfiline.
The Journal of organic chemistry 20011214
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Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686.
The Journal of endocrinology 20011201
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Why are the terpenoid indole alkaloids of type I homochiral?
Chirality 20010801
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Investigation of Uña De Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa.
Phytochemistry 20010701
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Improved method for the determination of oxindole alkaloids in Uncaria tomentosa by high performance liquid chromatography.
Planta medica 20010701
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Synthesis, absolute configuration, and enantiomeric enrichment of a cruciferous oxindole phytoalexin, (S)-(-)-spirobrassinin, and its oxazoline analog.
The Journal of organic chemistry 20010601
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Improved catalysts for the palladium-catalyzed synthesis of oxindoles by amide alpha-arylation. Rate acceleration, use of aryl chloride substrates, and a new carbene ligand for asymmetric transformations.
The Journal of organic chemistry 20010518
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Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.
Bioorganic & medicinal chemistry letters 20010507
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Diclofenac sodium injection sterilized by autoclave and the occurrence of cyclic reaction producing a small amount of impurity.
Journal of pharmaceutical sciences 20010501
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Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.
Cancer research 20010501
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AG-041R, a novel indoline-2-one derivative, induces systemic cartilage hyperplasia in rats.
European journal of pharmacology 20010427
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Two stereoisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E.
Acta crystallographica. Section C, Crystal structure communications 20010401
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Weekly dosing with the platelet-derived growth factor receptor tyrosine kinase inhibitor SU9518 significantly inhibits arterial stenosis.
Circulation research 20010330
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Novel oxindole derivatives and their biological activity.
Folia microbiologica 20010101
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Crystal structure of a conformation-selective casein kinase-1 inhibitor.
The Journal of biological chemistry 20000630
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Characterization of novel inhibitors of cyclin-dependent kinases.
Biochemical and biophysical research communications 19990714