59729-37-2 | Fexinidazole

Packsize	Purity	Availability	Price	Discounted Price
25mg	95%	in stock	$44.00	$31.00
100mg	98%	in stock	$106.00	$75.00
250mg	98%	in stock	$163.00	$114.00
1g	98%	in stock	$336.00	$236.00
5g	98%	in stock	$1,505.00	$1,054.00

Description

• Catalog Number: AG69028
• Chemical Name: Fexinidazole
• CAS Number: 59729-37-2
• Molecular Formula: C12H13N3O3S
• Molecular Weight: 279.3149
• MDL Number: MFCD00866607
• SMILES: CSc1ccc(cc1)OCc1ncc(n1C)[N+](=O)[O-]

Computed Properties

• Complexity: 305
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• XLogP3: 2.5

Literature

• Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).

  Mutagenesis 20120901

• Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies.

  Bioorganic & medicinal chemistry letters 20120715

• The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.

  Science translational medicine 20120201

• Development of novel drugs for human African trypanosomiasis.

  Future microbiology 20110601

• 1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.

  European journal of medicinal chemistry 20110501

• Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis.

  Bioorganic & medicinal chemistry letters 20110201

• Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.

  Current topics in medicinal chemistry 20110101

• Potential new drugs for human African trypanosomiasis: some progress at last.

  Current opinion in infectious diseases 20101201

• Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.

  PLoS neglected tropical diseases 20101201