60-80-0 | 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$13.00	$9.00
25g	98%	in stock	$15.00	$10.00
100g	98%	in stock	$43.00	$30.00
500g	>99.0%(GC)(T)	in stock	$169.00	$118.00

Description

• Catalog Number: AI53399
• Chemical Name: 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-
• CAS Number: 60-80-0
• Molecular Formula: C11H12N2O
• Molecular Weight: 188.2258
• MDL Number: MFCD00003146
• SMILES: O=c1cc(n(n1c1ccccc1)C)C

Computed Properties

• Complexity: 267
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 0.4

Literature

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• Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma.

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• Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse.

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  International journal of pharmaceutics 20121015

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  Experimental and molecular pathology 20121001

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  Molecular and cellular biochemistry 20121001

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• Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors.

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• Italian guidelines for primary headaches: 2012 revised version.

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• The predominance of type I oligosaccharides is a feature specific to human breast milk.

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  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20120501

• 1-[3-(Anthracen-9-yl)-5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20120501

• What is the role of free radical scavengers in acute stroke?

  JPMA. The Journal of the Pakistan Medical Association 20120501

• Phenylobacterium muchangponense sp. nov., isolated from beach soil, and emended description of the genus Phenylobacterium.

  International journal of systematic and evolutionary microbiology 20120401

• Quantitative liver function tests improve the prediction of clinical outcomes in chronic hepatitis C: results from the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis Trial.

  Hepatology (Baltimore, Md.) 20120401

• Glucuronidation of edaravone by human liver and kidney microsomes: biphasic kinetics and identification of UGT1A9 as the major UDP-glucuronosyltransferase isoform.

  Drug metabolism and disposition: the biological fate of chemicals 20120401

• Synthesis of D-ring-substituted (5'R)- and (5'S)-17β-pyrazolinylandrostene epimers and comparison of their potential anticancer activities.

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• Current advances in detection and treatment of babesiosis.

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• 1-[3-(4-Chloro-phen-yl)-5-(4-meth-oxy-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20120401

• 1-[3-(4-Chloro-phen-yl)-5-(4-meth-oxy-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]butan-1-one.

  Acta crystallographica. Section E, Structure reports online 20120401

• 1-(1,3-Benzothia-zol-2-yl)-3-phenyl-2-pyrazoline.

  Acta crystallographica. Section E, Structure reports online 20120401

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  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120315

• Synthesis and in vitro antifungal evaluation of 1,3,5-trisubstituted-2-pyrazoline derivatives.

  Chemical biology & drug design 20120301

• Recent advances in the therapeutic applications of pyrazolines.

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  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20120301

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  Acta crystallographica. Section E, Structure reports online 20120301

• 5-(4-Eth-oxy-phen-yl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

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• Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis.

  Hepatitis monthly 20120301

• Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients--a preliminary study.

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• Assessment of groundwater pollution in Tokyo using PPCPs as sewage markers.

  Environmental science & technology 20120207

• Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain.

  Brain research 20120203

• Lower rim 1,3-di{4-antipyrine}amide conjugate of calix[4]arene: synthesis, characterization, and selective recognition of Hg2+ and its sensitivity toward pyrimidine bases.

  The Journal of organic chemistry 20120203

• Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20120201

• Prediction and evaluation of fetal toxicity induced by NSAIDs using transplacental kinetic parameters obtained from human placental perfusion studies.

  British journal of clinical pharmacology 20120201

• Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro antibacterial, antifungal activities.

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• Combination of reactive oxygen species and tissue-type plasminogen activator enhances the induction of gelatinase B in brain endothelial cells.

  The International journal of neuroscience 20120201

• 3-(4-Chloro-phen-yl)-5-(thio-phen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

  Acta crystallographica. Section E, Structure reports online 20120201

• (2E)-1-(3,4-Dichloro-phen-yl)-3-(2-hy-droxy-phen-yl)prop-2-en-1-one.

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• On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library. 3. Focus on ion trap and upfront CID.

  Journal of mass spectrometry : JMS 20120201

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  The journal of physical chemistry. B 20120126

• Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs.

  Bioorganic & medicinal chemistry 20120115

• Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury.

  Neuroscience 20120110

• Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils.

  Neuroscience letters 20120106

• Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C(14)-erythromycin breath test and the antipyrine clearance test.

  Cancer chemotherapy and pharmacology 20120101

• Effect of Fasciola hepatica proteins on the functioning of rat hepatocytes.

  Parasitology research 20120101

• Validation of an HPLC method for the simultaneous determination of diminazene diaceturate and phenazone in injectable veterinary granules and bulk powders.

  Pakistan journal of pharmaceutical sciences 20120101

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  Bioorganic chemistry 20120101

• Kallolide A acetate pyrazoline.

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  Aviation, space, and environmental medicine 20120101

• Effect of edaravone on Aβ1-40 induced enhancement of voltage-gated calcium channel current.

  CNS neuroscience & therapeutics 20120101

• In vitro placental model optimization for nanoparticle transport studies.

  International journal of nanomedicine 20120101

• Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.

  Journal of pharmacological sciences 20120101

• Immunological response as a source to variability in drug metabolism and transport.

  Frontiers in pharmacology 20120101

• Validated HPLC Method for Concurrent Determination of Antipyrine, Carbamazepine, Furosemide and Phenytoin and its Application in Assessment of Drug Permeability through Caco-2 Cell Monolayers.

  Scientia pharmaceutica 20120101

• Comprehensive and facile synthesis of some functionalized bis-heterocyclic compounds containing a thieno[2,3-b]thiophene motif.

  International journal of molecular sciences 20120101

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  Nihon Hoshasen Gijutsu Gakkai zasshi 20120101

• The safety of cruciferous plants in humans: a systematic review.

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• The analgesic effect of different antidepressants combined with aspirin on thermally induced pain in Albino mice.

  The Libyan journal of medicine 20120101

• Binuclear Cu(II) and Co(II) Complexes of Tridentate Heterocyclic Shiff Base Derived from Salicylaldehyde with 4-Aminoantipyrine.

  Bioinorganic chemistry and applications 20120101

• Weekly intra-amniotic IGF-1 treatment increases growth of growth-restricted ovine fetuses and up-regulates placental amino acid transporters.

  PloS one 20120101

• Antitumor, Analgesic, and Anti-inflammatory Activities of Synthesized Pyrazolines.

  Journal of young pharmacists : JYP 20120101

• Density functional theory (DFT) study of edaravone derivatives as antioxidants.

  International journal of molecular sciences 20120101

• Robust calibration models to predict antipyrine content in various kinds of packaged hospital powder preparations by using near-infrared spectroscopy.

  Bio-medical materials and engineering 20120101

• Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina.

  Investigative ophthalmology & visual science 20111228

• Pregnenolone derivatives as potential anticancer agents.

  Steroids 20111220

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  Bioorganic & medicinal chemistry letters 20111215

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  The Cochrane database of systematic reviews 20111207

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  Journal of enzyme inhibition and medicinal chemistry 20111201

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  International journal of molecular medicine 20111201

• Experimental and theoretical study of two new pyrazoline derivatives based on dibenzofuran.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111201

• Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma.

  Journal of veterinary science 20111201

• (E)-1-(4,4''-Difluoro-5'-meth-oxy-1,1':3',1''-terphenyl-4'-yl)-3-(6-meth-oxy-naphthalen-2-yl)prop-2-en-1-one.

  Acta crystallographica. Section E, Structure reports online 20111201

• 5-(4-Meth-oxy-phen-yl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

  Acta crystallographica. Section E, Structure reports online 20111201

• A tale of two polymorphic pharmaceuticals: pyrithyldione and propyphenazone and their 1937 co-crystal patent.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20111125

• Gold(I)-catalyzed formation of 3-pyrazolines through cycloaddition of diaziridine to alkynes.

  Organic letters 20111104

• Optimization of monosaccharide determination using anthranilic acid and 1-phenyl-3-methyl-5-pyrazolone for gastropod analysis.

  Analytical biochemistry 20111101

• Relative quantitation of glycans using stable isotopic labels 1-(d0/d5) phenyl-3-methyl-5-pyrazolone by mass spectrometry.

  Analytical biochemistry 20111101

• The transfer of 6-mercaptopurine in the dually perfused human placenta.

  Reproductive toxicology (Elmsford, N.Y.) 20111101

• One-pot nonreductive O-glycan release and labeling with 1-phenyl-3-methyl-5-pyrazolone followed by ESI-MS analysis.

  Proteomics 20111101

• 3-(4-Meth-oxy-phen-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde.

  Acta crystallographica. Section E, Structure reports online 20111101

• (2E)-1-(2,5-Dimeth-oxy-phen-yl)-3-(3-nitro-phen-yl)prop-2-en-1-one.

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  Rinsho shinkeigaku = Clinical neurology 20111101

• Acquired platinum resistance enhances tumour angiogenesis through angiotensin II type 1 receptor in bladder cancer.

  British journal of cancer 20111025

• Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20111015

• Characterization of phenazone transformation products on light-activated TiO2 surface by high-resolution mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20111015

• Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs).

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20111009

• Preparation of starch-based pellets by hot-melt extrusion.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20111001

• The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis.

  Arthritis and rheumatism 20111001

• Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone.

  Developmental neuroscience 20111001

• Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.

  Journal of neurotrauma 20111001

• Passage of 4-nonylphenol across the human placenta.

  Placenta 20111001

• New method for absolute spinal cord ischemia protection in rabbits.

  Journal of vascular surgery 20111001

• 4-[2-(2-Meth-oxy-phen-yl)hydrazinyl-idene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

  Acta crystallographica. Section E, Structure reports online 20111001

• Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice.

  Investigative ophthalmology & visual science 20110921

• Singlet oxygen is essential for neutrophil extracellular trap formation.

  Biochemical and biophysical research communications 20110916

• Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20110910

• Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion.

  Toxicology letters 20110910

• Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110901

• Ionization energies, proton affinities, and pKa values of a large series of edaravone derivatives: implication for their free radical scavenging activity.

  The journal of physical chemistry. B 20110901

• Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents.

  European journal of medicinal chemistry 20110901

• Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates.

  Archiv der Pharmazie 20110801

• ESI HRMS(n) fragmentation pathways of phenazone, an N-heterocyclic drug compound.

  Journal of mass spectrometry : JMS 20110801

• 1-(4-Methyl-phenyl-sulfon-yl)-5-phenyl-4,5-dihydro-1H-pyrazole.

  Acta crystallographica. Section E, Structure reports online 20110801

• 3,5-Bis(4-meth-oxy-phen-yl)-4,5-dihydro-isoxazole.

  Acta crystallographica. Section E, Structure reports online 20110801

• Effects of CYP1A2 gene polymorphisms on antipyrine CYP1A2-dependent metabolism.

  Bulletin of experimental biology and medicine 20110801

• Comparison of polysaccharides from different Dendrobium using saccharide mapping.

  Journal of pharmaceutical and biomedical analysis 20110715

• Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies.

  Bioorganic & medicinal chemistry letters 20110715

• Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice.

  Naunyn-Schmiedeberg's archives of pharmacology 20110701

• Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia.

  Current molecular medicine 20110701

• A review on various heterocyclic moieties and their antitubercular activity.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110701

• 1,5-Dimethyl-4-(1-methyl-3-oxo-3-phenylprop-1-enyl-amino)-2-phenyl-1H-pyrazol-3(2H)-one.

  Acta crystallographica. Section E, Structure reports online 20110701

• [Preparation of rivastigmine liposome and its pharmacokinetics in rats after intranasal administration].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110701

• In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice.

  Brain research 20110623

• New treatment of free-radical scavenger in adrenoleukodystrophy.

  Journal of clinical pharmacy and therapeutics 20110601

• Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat.

  The journal of sexual medicine 20110601

• 3,5-Bis(4-fluoro-phen-yl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde.

  Acta crystallographica. Section E, Structure reports online 20110601

• Edaravone alleviates delayed neuronal death and long-dated cognitive dysfunction of hippocampus after transient focal ischemia in Wistar rat brains.

  Neuroscience 20110519

• Conformations of antipyrines.

  The journal of physical chemistry. A 20110512

• Acute inferior myocardial infarction with low atrial rhythm due to propyphenazone: Kounis syndrome.

  International journal of cardiology 20110505

• Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment.

  Investigative ophthalmology & visual science 20110501

• C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation.

  Arteriosclerosis, thrombosis, and vascular biology 20110501

• Solid-phase treatment with the fungus Trametes versicolor substantially reduces pharmaceutical concentrations and toxicity from sewage sludge.

  Bioresource technology 20110501

• Translational stroke research of the combination of thrombolysis and antioxidant therapy.

  Stroke 20110501

• Relationship between lipophilicity and absorption from the liver surface of paraben derivatives and antipyrine in rats.

  The Journal of pharmacy and pharmacology 20110501

• [Future neuroprotective strategies in the post-thrombolysis era--neurovascular unit protection and vascular endothelial protection].

  Rinsho shinkeigaku = Clinical neurology 20110501

• Modulation of the foreign body reaction for implants in the subcutaneous space: microdialysis probes as localized drug delivery/sampling devices.

  Journal of diabetes science and technology 20110501

• Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity.

  The Journal of biological chemistry 20110415

• Importance of physicochemical properties for the design of new pesticides.

  Journal of agricultural and food chemistry 20110413

• Self-medication of migraine and tension-type headache: summary of the evidence-based recommendations of the Deutsche Migräne und Kopfschmerzgesellschaft (DMKG), the Deutsche Gesellschaft für Neurologie (DGN), the Österreichische Kopfschmerzgesellschaft (ÖKSG) and the Schweizerische Kopfwehgesellschaft (SKG).

  The journal of headache and pain 20110401

• Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.

  Neuroscience research 20110401

• Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis.

  Drug metabolism and disposition: the biological fate of chemicals 20110401

• Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.

  Bioorganic & medicinal chemistry letters 20110401

• Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats.

  The Journal of pharmacy and pharmacology 20110401

• Edaravone, a hydroxyl radical scavenger, ameliorates the severity of pulmonary hypertension in a porcine model of neonatal sepsis.

  The Tohoku journal of experimental medicine 20110401

• Validated HPLC method for determination of caffeine level in human plasma using synthetic plasma: application to bioavailability studies.

  Journal of chromatographic science 20110401

• Prevalence and patterns of nitrosatable drug use among U.S. women during early pregnancy.

  Birth defects research. Part A, Clinical and molecular teratology 20110401

• 3,5-Bis(4-methyl-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

  Acta crystallographica. Section E, Structure reports online 20110401

• 2-Phenyl-8,9,10,11-tetra-hydro-1-benzo-thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine.

  Acta crystallographica. Section E, Structure reports online 20110401

• [Stimulative effect of edaravone on growth of neuronal stem cells and precursor cells following lesioning of hippocampal dentate gyrus].

  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20110401

• The use of convection-enhanced delivery with liposomal toxins in neurooncology.

  Toxins 20110401

• Transfer of PAMAM dendrimers across human placenta: prospects of its use as drug carrier during pregnancy.

  Journal of controlled release : official journal of the Controlled Release Society 20110330

• Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger.

  Brain research 20110325

• A new in situ brain perfusion flow correction method for lipophilic drugs based on the pH-dependent Crone-Renkin equation.

  Pharmaceutical research 20110301

• [Effects of edaravone on glial fibrillary acidic protein and interleukin-lβ expression and neuronal apoptosis in juvenile rat hippocampus after status convulsion].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110301

• [Separation of 1-phenyl-3-methyl-5-pyrazolone derivatives of traditional Chinese medicine oligosaccharides by capillary zone electrophoresis].

  Se pu = Chinese journal of chromatography 20110301

• Edaravone for acute intracerebral haemorrhage.

  The Cochrane database of systematic reviews 20110216

• Effects of GABA(A) receptor blockade on regional cerebral blood flow and blood-brain barrier disruption in focal cerebral ischemia.

  Journal of the neurological sciences 20110215

• OH radical scavenging activity of Edaravone: mechanism and kinetics.

  The journal of physical chemistry. B 20110210

• Towards a selected reaction monitoring mass spectrometry fingerprint approach for the screening of oligosaccharidoses.

  Analytica chimica acta 20110207

• Spontaneous intracerebral hemorrhage associated with ingestion of isometheptine containing anti-migraine medication.

  Clinical neurology and neurosurgery 20110201

• Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone.

  Bioorganic chemistry 20110201

• Effects of continuous intravenous infusion of MCI-186 on functional recovery after spinal cord injury in rats.

  Journal of neurotrauma 20110201

• Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†).

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110201

• 3,5-Bis(4-meth-oxy-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

  Acta crystallographica. Section E, Structure reports online 20110201

• (2E)-3-(3-Bromo-4-meth-oxy-phen-yl)-1-(pyridin-2-yl)prop-2-en-1-one.

  Acta crystallographica. Section E, Structure reports online 20110201

• 1-[5-(Anthracen-9-yl)-3-(4-nitro-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one.

  Acta crystallographica. Section E, Structure reports online 20110201

• 3-[5-(2,4-Dichloro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-4-hy-droxy-2H-chromen-2-one.

  Acta crystallographica. Section E, Structure reports online 20110201

• CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease.

  Journal of immunology (Baltimore, Md. : 1950) 20110115

• Synthesis and anti-bacterial activities of a bis-chalcone derived from thiophene and its bis-cyclized products.

  Molecules (Basel, Switzerland) 20110112

• Synthesis, reactions and biological evaluation of some new naphtho[2,1-b]furan derivatives bearing a pyrazole nucleus.

  Molecules (Basel, Switzerland) 20110105

• Effect of edaravone on the estimated glomerular filtration rate in patients with acute ischemic stroke and chronic kidney disease.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20110101

• A combined treatment for acute larger lacunar-type infarction.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20110101

• The synthesis, X-ray crystal structure and optical properties of novel 5-aryl-3-ferrocenyl-1-pyridazinyl-pyrazoline derivatives.

  Journal of fluorescence 20110101

• Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells.

  Pancreas 20110101

• Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?

  International immunopharmacology 20110101

• Effect of a free radical scavenger, edaravone, on free radical reactions: related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model.

  Acta neurochirurgica. Supplement 20110101

• Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A comparative study on edaravone derivatives.

  Journal of radiation research 20110101

• Placental transfer of the insulin analog glargine in the ex vivo perfused placental cotyledon model.

  Endocrine research 20110101

• Effects of edaravone on a rat model of punch-drunk syndrome.

  Neurologia medico-chirurgica 20110101

• Microwave assisted solvent free synthesis of 1,3-diphenylpropenones.

  Chemistry Central journal 20110101

• Cerebral changes occurring in arginase and dimethylarginine dimethylaminohydrolase (DDAH) in a rat model of sleeping sickness.

  PloS one 20110101

• [Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20110101

• Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model.

  Journal of burn care & research : official publication of the American Burn Association 20110101

• Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke.

  BMC neurology 20110101

• 1-[5-(Anthracen-9-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20110101

• Solid-phase extraction of antipyrine dye for spectrophotometric determination of phenolic compounds in water.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20110101

• Erythema multiforme due to antitubercular drugs.

  Lung India : official organ of Indian Chest Society 20110101

• Edaravone guards dopamine neurons in a rotenone model for Parkinson's disease.

  PloS one 20110101

• Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control.

  International journal of molecular sciences 20110101

• Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

  Journal of pharmacy & bioallied sciences 20110101

• Age-related changes in the hepatic pharmacology and toxicology of paracetamol.

  Current gerontology and geriatrics research 20110101

• Novel benzimidazole derivatives as expected anticancer agents.

  Acta poloniae pharmaceutica 20110101

• Antioxidant therapy: current status and future prospects.

  Current medicinal chemistry 20110101

• Mapping functional brain activation using [14C]-iodoantipyrine in male serotonin transporter knockout mice.

  PloS one 20110101

• Basophil activation test for investigation of IgE-mediated mechanisms in drug hypersensitivity.

  Journal of visualized experiments : JoVE 20110101

• Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs.

  Biological & pharmaceutical bulletin 20110101

• Infrared imaging and spectral-domain optical coherence tomography findings correlate with microperimetry in acute macular neuroretinopathy: a case report.

  Journal of medical case reports 20110101

• The state of the art of pyrazole derivatives as monoamine oxidase inhibitors and antidepressant/anticonvulsant agents.

  Current medicinal chemistry 20110101

• A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates.

  Scientia pharmaceutica 20110101

• [Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

• Detection and quantification of citrullinated chemokines.

  PloS one 20110101

• Chemical exposure as etiology in developmental origin of adult onset human cancer.

  Frontiers in pharmacology 20110101

• Edaravone attenuates impairment of synaptic plasticity in granule cell layer of the dentate gyrus following traumatic brain injury.

  The Kurume medical journal 20110101

• Protective effects of edaravone on experimental spinal cord injury in rats.

  Pediatric neurosurgery 20110101

• Pharmacogenetics and gender association with psychotic episodes on nortriptyline lower doses: patient cases.

  ISRN pharmaceutics 20110101

• Design, synthesis, and pharmacological activity of nonallergenic pyrazolone-type antipyretic analgesics.

  Journal of medicinal chemistry 20101223

• Edaravone: a new therapeutic approach for the treatment of acute stroke.

  Medical hypotheses 20101201

• Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes.

  Biomaterials 20101201

• Drug structure-transport relationships.

  Journal of pharmacokinetics and pharmacodynamics 20101201

• [ERK1/2 mediates edaravone-triggered protection against myocardial damage induced by isoprenaline in H9c2 cells].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20101201

• 3',7',7'-Trimethyl-1'-phenyl-5',6',7',8'-tetra-hydro-spiro-[indoline-3,4'-(1H,4H-pyrazolo-[3,4-b]chromene)]-2,5'-dione.

  Acta crystallographica. Section E, Structure reports online 20101201

• 2-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino]-1-methyl-2-oxoethyl pyrrolidine-1-carbodithio-ate.

  Acta crystallographica. Section E, Structure reports online 20101201

• 1-[5-(4-Meth-oxy-phen-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20101201

• A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation.

  Neuroscience letters 20101112

• Investigation of microdialysis sampling calibration approaches for lipophilic analytes: doxorubicin.

  Journal of pharmaceutical and biomedical analysis 20101102

• Synthesis and biological evaluation of N-antipyrine-4-substituted amino-3-chloromaleimide derivatives.

  European journal of medicinal chemistry 20101101

• Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities.

  European journal of medicinal chemistry 20101101

• Synthesis and molluscicidal evaluation of some new pyrazole, isoxazole, pyridine, pyrimidine, 1,4-thiazine and 1,3,4-thiadiazine derivatives incorporating benzofuran moiety.

  European journal of medicinal chemistry 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage.

  Current neurovascular research 20101101

• Human health risk assessment of pharmaceuticals in water: issues and challenges ahead.

  International journal of environmental research and public health 20101101

• 4-[(E)-3-Meth-oxy-5-nitro-4-(4-nitro-benz-yloxy)benzyl-idene-amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

  Acta crystallographica. Section E, Structure reports online 20101101

• 5-(Anthracen-9-yl)-3-(4-nitro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

  Acta crystallographica. Section E, Structure reports online 20101101

• [Concept of branch atheromatous disease (BAD) and its clinical significance].

  Rinsho shinkeigaku = Clinical neurology 20101101

• Gene network analysis to determine the effects of antioxidant treatment in a rat model of neonatal hypoxic-ischemic encephalopathy.

  Journal of molecular neuroscience : MN 20101001

• Relationships between solid dispersion preparation process, particle size and drug release--an NMR and NMR microimaging study.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101001

• Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail.

  European journal of medicinal chemistry 20101001

• 2-[5-(1,3-Benzodioxol-5-yl)-3-ferrocenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thia-zole.

  Acta crystallographica. Section E, Structure reports online 20101001

• 1-{5-[4-(Hex-yloxy)phen-yl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}ethanone.

  Acta crystallographica. Section E, Structure reports online 20101001

• Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina.

  European journal of pharmacology 20100910

• New pyrazoline derivatives and their antidepressant activity.

  European journal of medicinal chemistry 20100901

• Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.

  Heart and vessels 20100901

• The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis.

  Free radical research 20100901

• Effects of edaravone on muscle atrophy and locomotor function in patients with ischemic stroke: a randomized controlled pilot study.

  Drugs in R&D 20100901

• Development and validation of an HPLC method for simultaneous determination of trimethoprim and sulfamethoxazole in human plasma.

  European journal of drug metabolism and pharmacokinetics 20100901

• 2-Amino-5-methyl-pyridinium 2-hy-droxy-benzoate.

  Acta crystallographica. Section E, Structure reports online 20100901

• Ethyl 2-[(Z)-2-benzyl-hydrazin-1-yl-idene]-2-bromo-acetate.

  Acta crystallographica. Section E, Structure reports online 20100901

• Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.

  Journal of medicinal chemistry 20100826

• Placental transfer and DNA binding of benzo(a)pyrene in human placental perfusion.

  Toxicology letters 20100816

• Discovery and optimization of pyrazoline compounds as B-Raf inhibitors.

  Bioorganic & medicinal chemistry letters 20100815

• Quality assessment of a placental perfusion protocol.

  Reproductive toxicology (Elmsford, N.Y.) 20100801

• Preparation of some pyrazoline derivatives and evaluation of their antifungal activities.

  Journal of enzyme inhibition and medicinal chemistry 20100801

• Synthesis of novel alpha-pyranochalcones and pyrazoline derivatives as Plasmodium falciparum growth inhibitors.

  Bioorganic & medicinal chemistry letters 20100801

• Investigation of the microbial degradation of phenazone-type drugs and their metabolites by natural biofilms derived from river water using liquid chromatography/tandem mass spectrometry (LC-MS/MS).

  Water research 20100801

• 1-(3'-[125I]Iodophenyl)-3-methy-2-pyrazolin-5-one: preparation, solution stability, and biodistribution in normal mice.

  Chemical & pharmaceutical bulletin 20100801

• Di-μ-chlorido-bis-{chlorido[(R)/(S)-1,5-di-phenyl-3-(2-pyridyl-κN)-2-pyrazoline-κN]zinc(II)}.

  Acta crystallographica. Section E, Structure reports online 20100801

• 3,5-Bis(4-fluoro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

  Acta crystallographica. Section E, Structure reports online 20100801

• 1-[3,5-Bis(4-chloro-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20100801

• 4-[(1-Hy-droxy-2-naphth-yl)methyl-ene-amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

  Acta crystallographica. Section E, Structure reports online 20100801

• Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.

  Cancer letters 20100701

• A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?

  Expert opinion on pharmacotherapy 20100701

• Toxicokinetics of the food-toxin IQ in human placental perfusion is not affected by ABCG2 or xenobiotic metabolism.

  Placenta 20100701

• VUV photon-induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights.

  Journal of mass spectrometry : JMS 20100701

• Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats.

  Yao xue xue bao = Acta pharmaceutica Sinica 20100701

• 1,5-Dimethyl-4-{[1-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl-idene)eth-yl]amino}-2-phenyl-1H-pyrazol-3(2H)-one.

  Acta crystallographica. Section E, Structure reports online 20100701

• 1-[3-(2-Nitro-phen-yl)-5-phenyl-2-pyrazolin-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20100701

• 4-{(E)-[2-(4-Iodo-but-oxy)benzyl-idene]amino}-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

  Acta crystallographica. Section E, Structure reports online 20100701

• A novel method for inducing focal ischemia in vitro.

  Journal of neuroscience methods 20100630

• A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery.

  Journal of neuroscience methods 20100630

• Scavenging activity of aminoantipyrines against hydroxyl radical.

  European journal of medicinal chemistry 20100601

• Long-term calibration considerations during subcutaneous microdialysis sampling in mobile rats.

  Biomaterials 20100601

• Transplacental transfer and biotransformation of genistein in human placenta.

  Placenta 20100601

• 3,5-Bis(4-bromo-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

  Acta crystallographica. Section E, Structure reports online 20100601

• 4-[(Z)-Allyl-amino-(phen-yl)methyl-ene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

  Acta crystallographica. Section E, Structure reports online 20100601

• (E)-5-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino-meth-yl]-2-methoxy-phenyl 4-bromo-benzene-sulfonate.

  Acta crystallographica. Section E, Structure reports online 20100601

• 2-Amino-5-chloro-pyridinium salicylate.

  Acta crystallographica. Section E, Structure reports online 20100601

• Two-column sequential injection chromatography--new approach for fast and effective analysis and its comparison with gradient elution chromatography.

  Analytica chimica acta 20100523

• Edaravone directly reacts with singlet oxygen and protects cells from attack.

  Life sciences 20100522

• Is the mechanisms of fipronil-induced thyroid disruption specific of the rat: Re-evaluation of fipronil thyroid toxicity in sheep?

  Toxicology letters 20100504

• Transplacental transfer and metabolism of bupropion.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20100501

• The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats.

  Anesthesia and analgesia 20100501

• Antimicrobial activity of new 4,6-disubstituted pyrimidine, pyrazoline, and pyran derivatives.

  Archives of pharmacal research 20100501

• (4Z)-4-[(Cyclo-propyl-amino)(phen-yl)methyl-ene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

  Acta crystallographica. Section E, Structure reports online 20100501

• Transfer of bisphenol A across the human placenta.

  American journal of obstetrics and gynecology 20100401

• [A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20100401

• [Effect of edaravone on extracellular signal-regulated kinase 1/2 pathway following severe traumatic brain injury in rats].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20100401

• [Development of a new HPLC technique for analyzing monosaccharide composition and its application in the quality control of Silybum marianum polysaccharide].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100401

• Determination of pharmaceuticals in river water by column switching of large sample volumes and liquid chromatography-diode array detection, assisted by chemometrics: an integrated approach to green analytical methodologies.

  Journal of chromatography. A 20100326

• Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.

  European journal of pharmacology 20100325

• Hochuekkito, a Kampo (traditional Japanese herbal) Medicine, Enhances Mucosal IgA Antibody Response in Mice Immunized with Antigen-entrapped Biodegradable Microparticles.

  Evidence-based complementary and alternative medicine : eCAM 20100301

• Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis.

  BJU international 20100301

• Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms.

  Antioxidants & redox signaling 20100301

• Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.

  Neuroscience research 20100301

• Barrier capacity of human placenta for nanosized materials.

  Environmental health perspectives 20100301

• Experimental and theoretical studies on o-, m- and p-chlorobenzylideneaminoantipyrines.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100301

• Application of photo-fenton as a tertiary treatment of emerging contaminants in municipal wastewater.

  Environmental science & technology 20100301

• Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies.

  Bioorganic & medicinal chemistry 20100301

• N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system.

  Anesthesia and analgesia 20100301

• [Protection of edaravone on neurons and its effects on the expression of interleukin-lbeta in juvenile rat hippocampus following status convulsion].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20100301

• Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats.

  The Journal of pharmacy and pharmacology 20100301

• 3-Chloro-6-{4-[3-(trifluoro-meth-yl)phen-yl]piperazin-1-yl}pyridazine.

  Acta crystallographica. Section E, Structure reports online 20100301

• 1-[3,5-Bis(4-fluoro-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20100301

• Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model?

  The British journal of radiology 20100201

• Edaravone, a free radical scavenger, in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss.

  Auris, nasus, larynx 20100201

• Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats.

  Neurochemical research 20100201

• Metal-based biologically active agents: Synthesis, characterization, antibacterial and antileukemia activity evaluation of Cu(II), V(IV) and Ni(II) complexes with antipyrine-derived compounds.

  European journal of medicinal chemistry 20100201

• Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery--a pilot study.

  Naunyn-Schmiedeberg's archives of pharmacology 20100201

• 6-Chloro-3-[5-(4-fluoro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2-methyl-4-phenyl-quinoline.

  Acta crystallographica. Section E, Structure reports online 20100201

• The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100131

• Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro.

  Brain research 20100111

• Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat.

  NeuroImage 20100101

• Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20100101

• Insulin glargine safety in pregnancy: a transplacental transfer study.

  Diabetes care 20100101

• Degradation of fifteen emerging contaminants at microg L(-1) initial concentrations by mild solar photo-Fenton in MWTP effluents.

  Water research 20100101

• Pyrazoline bearing benzimidazoles: search for anticancer agent.

  European journal of medicinal chemistry 20100101

• Vibrational spectroscopic study of o-, m- and p-hydroxybenzylideneaminoantipyrines.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100101

• Small temperature variations alter edaravone-induced neuroprotection of cortical cultures exposed to prolonged hypoxic episodes.

  British journal of anaesthesia 20100101

• Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies.

  Bioorganic & medicinal chemistry letters 20100101

• Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells.

  Neurochemistry international 20100101

• Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.

  Bioorganic & medicinal chemistry letters 20100101

• Investigation of the intestinal permeability and first-pass metabolism of drugs in cynomolgus monkeys using single-pass intestinal perfusion.

  Biological & pharmaceutical bulletin 20100101

• Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function.

  Aktuelle Urologie 20100101

• A novel administration route of edaravone--II: mucosal absorption of edaravone from edaravone/hydroxypropyl-beta-cyclodextrin complex solution including L-cysteine and sodium hydrogen sulfite.

  Pharmacology 20100101

• Effects of fentanyl pretreatment on regional cerebral blood flow in focal cerebral ischemia in rats.

  Pharmacology 20100101

• Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment? A retrospective study of edaravone therapy.

  Clinical drug investigation 20100101

• Psychiatric comorbidity and suicide risk in patients with chronic migraine.

  Neuropsychiatric disease and treatment 20100101

• Clinical research on liver reserve function by 13C-phenylalanine breath test in aged patients with chronic liver diseases.

  BMC geriatrics 20100101

• Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study.

  Environmental health : a global access science source 20100101

• Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine.

  Neuropsychiatric disease and treatment 20100101

• Adsorption and quantum chemical studies on the inhibition potentials of some thiosemicarbazides for the corrosion of mild steel in acidic medium.

  International journal of molecular sciences 20100101

• In vitro studies of ferric carboxymaltose on placental permeability using the dual perfusion model of human placenta.

  Arzneimittel-Forschung 20100101

• Evaluation of In Vitro Activity of Essential Oils against Trypanosoma brucei brucei and Trypanosoma evansi.

  Journal of parasitology research 20100101

• Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve.

  Molecular vision 20100101

• Protective effect of edaravone against PrP106-126-induced PC12 cell death.

  Journal of biochemical and molecular toxicology 20100101

• Antidiarrhoea and toxicological evaluation of the leaf extract of Dissotis rotundifolia Triana (Melastomataceae).

  BMC complementary and alternative medicine 20100101

• Antibiotic Treatment of Dogs and Cats during Pregnancy.

  Veterinary medicine international 20100101

• Synthesis and Antimicrobial Activity of 2-[2-(2,6-dichloro phenyl)amino]benzyl-3-(5-substituted phenyl-4,5-dihydro-1H-pyrazol-3-yl-amino)-6,8-dibromoquinazolin-4(3H)ones.

  Journal of young pharmacists : JYP 20100101

• Senna occidentalis leaf extract possesses antitrypanosomal activity and ameliorates the trypanosome-induced anemia and organ damage.

  Pharmacognosy research 20100101

• Synthesis and Biological Evaluation of Chalcones having Heterosubstituent(s).

  Indian journal of pharmaceutical sciences 20100101

• A novel electrochemical sensor for probing doxepin created on a glassy carbon electrode modified with poly(4-amino- benzoic acid)/multi-walled carbon nanotubes composite film.

  Sensors (Basel, Switzerland) 20100101

• Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4.

  Biochemical and biophysical research communications 20091225

• Edaravone, a novel free radical scavenger, reduces high-mobility group box 1 and prolongs survival in a neonatal sepsis model.

  Shock (Augusta, Ga.) 20091201

• Long-lasting enhancement of CYP activity after discontinuation of repeated administration of phenobarbital in dogs.

  Research in veterinary science 20091201

• Influence of perfusate composition on drug disposition in the in-situ perfused rat lung.

  International journal of pharmaceutics 20091201

• Contribution and limit of the model of perfused cotyledon to the study of placental transfer of drugs. Example of a protease inhibitor of HIV: nelfinavir.

  European journal of obstetrics, gynecology, and reproductive biology 20091201

• Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

  Bioorganic & medicinal chemistry letters 20091201

• Effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction.

  Journal of cardiology 20091201

• [The protective effect of edaravone on the treatment of sepsis in rats].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20091201

• 5-Bromo-2-[5-(4-nitro-phen-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]pyrimidine.

  Acta crystallographica. Section E, Structure reports online 20091201

• The characteristics of enriched nitrifier culture in the degradation of selected pharmaceutically active compounds.

  Journal of hazardous materials 20091115

• Correlation between in vitro dissolution profiles from enteric-coated dosage forms and in vivo absorption in rats for high-solubility and high-permeability model drugs.

  Journal of pharmaceutical sciences 20091101

• Coupling of solid-phase microextraction with micellar desorption and high performance liquid chromatography for the determination of pharmaceutical residues in environmental liquid samples.

  Biomedical chromatography : BMC 20091101

• Biological activities of pyrazoline derivatives--a recent development.

  Recent patents on anti-infective drug discovery 20091101

• The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.

  Neurotoxicity research 20091101

• Edaravone (MCI-186) is effective as a free radical scavenger following arteriovenous sheathotomy for treatment of macular oedema associated with branch retinal vein occlusion.

  The British journal of ophthalmology 20091101

• At the biological modeling and simulation frontier.

  Pharmaceutical research 20091101

• Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy.

  Journal of forensic and legal medicine 20091101

• Phenylpyrazolone derivatives inhibit gastric emptying in rats by a capsaicin-sensitive afferent pathway.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20091101

• (4Z)-4-[(4-Methoxy-benzyl-amino)(phen-yl)methyl-ene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

  Acta crystallographica. Section E, Structure reports online 20091101

• 4-[1-Acetyl-3-(4-methoxy-phen-yl)-2-pyrazolin-5-yl]phenol.

  Acta crystallographica. Section E, Structure reports online 20091101

• Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction.

  Chemical communications (Cambridge, England) 20091007

• Changes of expression of glucose transporters in the fetal lamb brain after MCI-186 administration to the maternal circulation with 10-min persistent umbilical cord occlusion.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20091001

• Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury.

  Muscle & nerve 20091001

• Modeling placental transport: correlation of in vitro BeWo cell permeability and ex vivo human placental perfusion.

  Toxicology in vitro : an international journal published in association with BIBRA 20091001

• Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF.

  Journal of neurochemistry 20091001

• Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

  Bioorganic & medicinal chemistry 20091001

• [Synthesis and spectrum of novel pyrazoline fluorescent compounds].

  Guang pu xue yu guang pu fen xi = Guang pu 20091001

• Edaravone, a free radical scavenger, retards the development of amygdala kindling in rats.

  Neuroscience letters 20090925

• Experimental and theoretical comparative studies on two 2-pyrazoline derivatives.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090915

• Antifibrotic effect of edaravone in rat liver cirrhosis induced by dimethylnitrosamine.

  Clinical and experimental medicine 20090901

• Mechanistic insight into neurotoxicity of tissue plasminogen activator-induced thrombolysis products in a rat intraluminal middle cerebral artery occlusion model.

  Journal of neurotrauma 20090901

• Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free-radical scavenger.

  BJU international 20090901

• Accumulation of oxidative stress around the stroke-like lesions of MELAS patients.

  Mitochondrion 20090901

• Experimental and theoretical studies on vibrational spectra of 4-(2-furanylmethyleneamino)antipyrine, 4-benzylideneaminoantipyrine and 4-cinnamilideneaminoantipyrine.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090901

• Development of cardiac dysfunction induced by repetitive transient myocardial ischemia is inhibited by edaravone in conscious rats.

  Clinical and experimental pharmacology & physiology 20090901

• Sex differences in functional brain activation during noxious visceral stimulation in rats.

  Pain 20090901

• Targeted analysis of protein citrullination using chemical modification and tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20090901

• Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.

  Chemical research in toxicology 20090901

• Effects of some 1,3,5-trisubstitued-2-pyrazoline derivatives on depression and anxiety parameters of mice.

  Archives of pharmacal research 20090901

• 4-{(Z)-(sec-Butyl-amino)(phen-yl)methyl-ene}-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

  Acta crystallographica. Section E, Structure reports online 20090901

• 5-(2-Fur-yl)-3-methyl-1-(3-nitro-phen-yl)-4,5-dihydro-1H-pyrazole.

  Acta crystallographica. Section E, Structure reports online 20090901

• 3-Methyl-1-(3-nitro-phen-yl)-5-phenyl-4,5-dihydro-1H-pyrazole.

  Acta crystallographica. Section E, Structure reports online 20090901

• 5-Benzoyl-N,4-diphenyl-4,5-dihydro-1H-pyrazole-3-carboxamide.

  Acta crystallographica. Section E, Structure reports online 20090901

• 3-(3,4-Dichloro-phen-yl)-1-(2-naphth-yl)prop-2-en-1-one.

  Acta crystallographica. Section E, Structure reports online 20090901

• Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage.

  Chinese medical journal 20090820

• Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model.

  Neuroscience 20090818

• Experimental and theoretical studies on 4-(2,4-dichlorobenzylideneamino)antipyrine and 4-(2,6-dichlorobenzylideneamino)antipyrine.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090815

• Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model.

  The British journal of radiology 20090801

• Effect of plasma proteins on buprenorphine transfer across dually perfused placental lobule.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20090801

• Anterior spinal artery as a collateral channel in patients with acute bilateral vertebral artery occlusions. Two case reports.

  Neurologia medico-chirurgica 20090801

• Ethanol consumption by Wistar rat dams affects selenium bioavailability and antioxidant balance in their progeny.

  International journal of environmental research and public health 20090801

• [Effects of edaravone on the expression of interleukin-1beta, nuclear factor-kappaB and neuron apoptosis in juvenile rat hippocampus after status convulsion].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20090801

• Performance of UV and UV/H2O2 processes for the removal of pharmaceuticals detected in secondary effluent of a sewage treatment plant in Japan.

  Journal of hazardous materials 20090730

• Could quantitative liver function tests gain wide acceptance among hepatologists?

  World journal of gastroenterology 20090728

• Synthesis of 1-phenyl-3-biphenyl-5-(N-ethylcarbazole-3-yl)-2-pyrazoline and its use as DNA probe.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090715

• The effect of probenecid and MK-571 on the feto-maternal transfer of saquinavir in dually perfused human term placenta.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090712

• Edaravone, a free radical scavenger, mitigates both gray and white matter damages after global cerebral ischemia in rats.

  Brain research 20090707

• Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives.

  European journal of medicinal chemistry 20090701

• Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells.

  Molecular and cellular biochemistry 20090701

• Ischemia independent lesion evolution during focal stroke in rats.

  Experimental neurology 20090701

• Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox(-/-) mice.

  Laboratory investigation; a journal of technical methods and pathology 20090701

• Therapeutic effect of edaravone on inner ear barotrauma in the guinea pig.

  Neurochemistry international 20090701

• Dimethylarginine dimethylaminohydrolase in rat penile tissue: reduced enzyme activity is responsible for erectile dysfunction in a rat model of atherosclerosis.

  International journal of impotence research 20090701

• Protective effect of dermorphin analogue sedatin on indomethacin-induced injury to the gastric mucosa.

  Bulletin of experimental biology and medicine 20090701

• Synthesis and antinociceptive activities of some pyrazoline derivatives.

  European journal of medicinal chemistry 20090601

• A novel fluorescent assay for edaravone with aqueous functional CdSe quantum dots.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090601

• Edaravone inhibits DNA peroxidation and neuronal cell death in neonatal hypoxic-ischemic encephalopathy model rat.

  Pediatric research 20090601

• Edaravone in ALS.

  Experimental neurology 20090601

• The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.

  The Journal of pharmacology and experimental therapeutics 20090601

• Electrophysiological study on differentiation of rat bone marrow stromal stem cells into neuron-like cells in vitro by edaravone.

  Chinese journal of traumatology = Zhonghua chuang shang za zhi 20090601

• [Effects of edaravone on IRE1 mRNA expression and neuronal apoptosis in the hippocampus of rats with status convulsivus].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090601

• Acute myocardial infarction and Kounis syndrome.

  International journal of cardiology 20090515

• A novel administration route for edaravone: I. Effects of metabolic inhibitors on skin permeability of edaravone.

  International journal of pharmaceutics 20090508

• Thermophilic treatment of bulk drug pharmaceutical industrial wastewaters by using hybrid up flow anaerobic sludge blanket reactor.

  Bioresource technology 20090501

• Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo.

  The Journal of pharmacology and experimental therapeutics 20090501

• Transplacental pharmacokinetics of diclofenac in perfused human placenta.

  Drug metabolism and disposition: the biological fate of chemicals 20090501

• Retinal artery embolization during carotid angioplasty and carotid artery stenting: case report.

  Neurologia medico-chirurgica 20090501

• Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart.

  Heart and vessels 20090501

• Quantification of 4-methylaminoantipyrine, the active metabolite of dipyrone, in human plasma.

  Bioanalysis 20090501

• 2-Methyl-1,10b-dihydro-5H-pyrazolo[1,5-c][1,3]benzoxazin-5-one.

  Acta crystallographica. Section E, Structure reports online 20090501

• Indirect photodegradation of amine drugs in aqueous solution under simulated sunlight.

  Environmental science & technology 20090415

• Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.

  European journal of medicinal chemistry 20090401

• Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone.

  Clinical and experimental nephrology 20090401

• Vascular perfused segments of human intestine as a tool for drug absorption.

  Drug metabolism and disposition: the biological fate of chemicals 20090401

• Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090401

• Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H(2)O(2).

  Water research 20090401

• Protective effects of edaravone against cobalt chloride-induced apoptosis in PC12 cells.

  Neuroscience bulletin 20090401

• Edaravone reduces brain oedema and attenuates cell death after intracerebral haemorrhage in mice.

  Brain injury 20090401

• Structural and photoluminescent studies of lanthanide complexes with tripodal triRNTB (N-substituted tris(benzimidazol-2-ylmethyl)amine): ligand substituent, anionic and secondary ligand effects.

  Dalton transactions (Cambridge, England : 2003) 20090328

• Efficient approach to androstene-fused arylpyrazolines as potent antiproliferative agents. Experimental and theoretical studies of substituent effects on BF(3)-catalyzed intramolecular [3 + 2] cycloadditions of olefinic phenylhydrazones.

  Journal of the American Chemical Society 20090325

• Synthesis and spectral characteristics of two novel intramolecular charge transfer fluorescent dyes.

  Talanta 20090315

• Determination of cyclophosphamide enantiomers in plasma by LC-MS/MS: Application to pharmacokinetics in breast cancer and lupus nephritis patients.

  Chirality 20090301

• Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells.

  Journal of neuroscience research 20090301

• Microbial degradation of pharmaceuticals in estuarine and coastal seawater.

  Environmental pollution (Barking, Essex : 1987) 20090301

• Quantitative tests of liver function measure hepatic improvement after sustained virological response: results from the HALT-C trial.

  Alimentary pharmacology & therapeutics 20090301

• Investigation of the role of oligopeptide transporter PEPT1 and sodium/glucose cotransporter SGLT1 in intestinal absorption of their substrates using small GTP-binding protein Rab8-null mice.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• Transplacental transfer of nitrosodimethylamine in perfused human placenta.

  Placenta 20090301

• Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage.

  Neurosurgery 20090301

• [Topics of the brain protection in neonate, which has been your better choice, the brain hypothermia or the medicine?].

  No to hattatsu = Brain and development 20090301

• Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells.

  International journal of pharmaceutics 20090223

• Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells.

  Neuroscience 20090218

• Porcine buccal mucosa as an in vitro model: relative contribution of epithelium and connective tissue as permeability barriers.

  Journal of pharmaceutical sciences 20090201

• Expression of syndecan-2 in the amoeboid microglial cells and its involvement in inflammation in the hypoxic developing brain.

  Glia 20090201

• Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

  Stroke 20090201

• Oxidative stress and monooxygenase liver function in patients with coronary heart disease and multiple organ dysfunction syndrome.

  European journal of anaesthesiology 20090201

• Antioxidant potential of new pyrazoline derivatives to prevent oxidative damage.

  Basic & clinical pharmacology & toxicology 20090201

• Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress.

  Expert opinion on pharmacotherapy 20090201

• [Edaravone protects hearing from acute acoustic trauma in guinea pigs].

  Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20090201

• 1-Acetyl-5-ferrocenyl-3-phenyl-2-pyrazoline.

  Acta crystallographica. Section E, Structure reports online 20090201

• Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

• Edaravone derivatives containing NO-donor functions.

  Journal of medicinal chemistry 20090122

• Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents.

  Bioorganic & medicinal chemistry 20090115

• New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.

  Bioorganic & medicinal chemistry 20090115

• Edaravone, a free radical scavenger, is effective on neuropathic pain in rats.

  Brain research 20090112

• Fipronil-induced disruption of thyroid function in rats is mediated by increased total and free thyroxine clearances concomitantly to increased activity of hepatic enzymes.

  Toxicology 20090108

• Synthesis, spectral studies and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines.

  European journal of medicinal chemistry 20090101

• Synthesis, characterization, antioxidant activity and DNA-binding studies of three rare earth (III) complexes with 1-(4-aminoantipyrine)-3-tosylurea ligand.

  Journal of fluorescence 20090101

• Protective effect of edaravone against tobramycin-induced ototoxicity.

  Acta oto-laryngologica 20090101

• Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus.

  Seizure 20090101

• Low-dose edaravone injection into the clamped aorta prevents ischemic spinal cord injury.

  Annals of vascular surgery 20090101

• Bilateral middle cerebral artery infarctions following mild varicella infection: a case report.

  Brain & development 20090101

• The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator.

  Experimental neurology 20090101

• Bioorthogonal ligation in the spotlight.

  Angewandte Chemie (International ed. in English) 20090101

• Protective effects of free radical scavenger edaravone against xanthine oxidase-mediated permeability increases in human intestinal epithelial cell monolayer.

  Journal of burn care & research : official publication of the American Burn Association 20090101

• [Thrombolysis by intravenous tissue plasminogen activator (t-PA)--current status and future direction].

  Brain and nerve = Shinkei kenkyu no shinpo 20090101

• Signaling pathway on the effect of oxygenated warm perfusion prior to cold preservation of the liver grafts from non-heart-beating donors, and the additive effect of edaravone.

  Transplantation proceedings 20090101

• Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial).

  Cerebrovascular diseases (Basel, Switzerland) 20090101

• Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction.

  Internal medicine (Tokyo, Japan) 20090101

• [Lipid peroxidation and cytochrome P-450-dependent metabolism of xenobiotics in patients with coronary heart disease and multiple organ failure].

  Anesteziologiia i reanimatologiia 20090101

• The impact of cocaine and heroin on the placental transfer of methadone.

  Reproductive biology and endocrinology : RB&E 20090101

• Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture.

  Journal of anesthesia 20090101

• Influence of overt diabetes mellitus on cyclosporine pharmacokinetics in a canine model.

  Experimental diabetes research 20090101

• Why amphibians are more sensitive than mammals to xenobiotics.

  PloS one 20090101

• Novel 3-(p-substituted phenyl)-6-bromo-4(3H)-quinazolinone derivatives of promising antiinflammatory and analgesic properties.

  Acta poloniae pharmaceutica 20090101

• Pathophysiological changes that affect drug disposition in protein-energy malnourished children.

  Nutrition & metabolism 20090101

• Antibody-dependent transplacental transfer of malaria blood-stage antigen using a human ex vivo placental perfusion model.

  PloS one 20090101

• Functional role of p-glycoprotein and binding protein effect on the placental transfer of lopinavir/ritonavir in the ex vivo human perfusion model.

  Obstetrics and gynecology international 20090101

• Therapeutic properties and tolerance of procaine and phenazone containing ear drops in infants and very young children.

  Arzneimittel-Forschung 20090101

• Repeated edaravone treatment reduces oxidative cell damage in rat brain induced by middle cerebral artery occlusion.

  Redox report : communications in free radical research 20090101

• Applications of nanomaterials in electrochemical enzyme biosensors.

  Sensors (Basel, Switzerland) 20090101

• Simultaneous determination of acrylamide, its metabolite glycidamide and antipyrine in human placental perfusion fluid and placental tissue by liquid chromatography-electrospray tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081215

• Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages.

  Shock (Augusta, Ga.) 20081201

• Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction.

  European journal of clinical pharmacology 20081201

• Correlation of free radical level and apoptosis after intracerebral hemorrhage in rats.

  Neuroscience bulletin 20081201

• Ranking of pharmaceuticals detected in the environment: aggregation and weighting procedures.

  Combinatorial chemistry & high throughput screening 20081201

• Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model.

  Neurologia medico-chirurgica 20081201

• Current migraine management - patient acceptability and future approaches.

  Neuropsychiatric disease and treatment 20081201

• [3-(4-Chloro-phen-yl)-5-hydr-oxy-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl](3-pyrid-yl)methanone.

  Acta crystallographica. Section E, Structure reports online 20081201

• Synthesis, fungicidal, and insecticidal activities of beta-Methoxyacrylate-containing N-acetyl pyrazoline derivatives.

  Journal of agricultural and food chemistry 20081126

• Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta.

  Toxicology letters 20081110

• Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice.

  The European respiratory journal 20081101

• Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model.

  Journal of pediatric surgery 20081101

• [A comparison of protective effect of propofol and edaravone pretreatment against cerebral ischemia-reperfusion injury].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20081101

• Validation of the use of nonnaive surgically catheterized rats for pharmacokinetics studies.

  Journal of the American Association for Laboratory Animal Science : JAALAS 20081101

• [Neuroprotective therapy for ischemic stroke with free radical scavenger and gene-stem cell therapy].

  Rinsho shinkeigaku = Clinical neurology 20081101

• 1-[3-(2,4-Dichloro-5-fluoro-phen-yl)-5-(3-methyl-2-thien-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20081101

• Changes in regional brain perfusion during functional brain activation: comparison of [(64)Cu]-PTSM with [(14)C]-Iodoantipyrine.

  Brain research 20081009

• Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

  Journal of medicinal chemistry 20081009

• Synthesis and antimicrobial activity of some new heterocycles incorporating antipyrine moiety.

  European journal of medicinal chemistry 20081001

• Kinetics of gold nanoparticles in the human placenta.

  Reproductive toxicology (Elmsford, N.Y.) 20081001

• Biphasic effects of free radical scavengers against bleomycin-induced pulmonary fibrosis.

  Pulmonary pharmacology & therapeutics 20081001

• Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice.

  Experimental neurology 20081001

• Transport kinetics of cisplatin in the perfused human placental lobule in vitro.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20081001

• Pharmacogenomics.

  Indian journal of pharmacology 20081001

• [Cardioprotective effect of edaravone pharmacological postconditioning on acute myocardial ischemia/reperfusion injury: experiment with rats].

  Zhonghua yi xue za zhi 20080923

• Protective effects of edaravone against ischemia-induced facial palsy.

  Auris, nasus, larynx 20080901

• Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors.

  European journal of medicinal chemistry 20080901

• The antioxidative activity of riboflavin in the presence of antipyrin. Spectroscopic studies.

  Journal of fluorescence 20080901

• Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway.

  Journal of neurochemistry 20080901

• Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice.

  Metabolic brain disease 20080901

• Preventive effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced lung injury in mice.

  Respirology (Carlton, Vic.) 20080901

• A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors.

  Transplantation proceedings 20080901

• [Outcome assessment in treatment of edaravone in childhood ischemic stroke].

  No to hattatsu = Brain and development 20080901

• 1,5-Dimethyl-4-[(E)-3-phenoxy-benzyl-ideneamino]-2-phenyl-1H-pyrazol-3(2H)-one.

  Acta crystallographica. Section E, Structure reports online 20080901

• 3,5-Bis[1-acetyl-5-(4-chloro-phen-yl)-4,5-dihydro-1H-pyrazol-3-yl]-2,6-dimethyl-pyridine.

  Acta crystallographica. Section E, Structure reports online 20080901

• 1-[5-(3,4-Dichlorophenyl)-3-(2-naphthyl)-4,5-dihydropyrazol-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20080901

• 3,5-Dimethyl-1-(2-pyridylcarbon-yl)-5-[(2-pyridylcarbon-yl)hydrazino]-2-pyrazoline methanol hemisolvate.

  Acta crystallographica. Section E, Structure reports online 20080901

• Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice.

  Neuroscience letters 20080822

• Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model.

  Chinese medical journal 20080820

• How close can you get? Studies of ultrafast light-induced processes in ruthenium-[60] fullerene dyads with short pyrazolino and pyrrolidino links.

  Inorganic chemistry 20080818

• Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis.

  Neuroscience letters 20080808

• Effect of medical castration on CYP3A4 enzyme activity using the erythromycin breath test.

  Cancer chemotherapy and pharmacology 20080801

• Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax.

  Shock (Augusta, Ga.) 20080801

• Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2.

  Biological & pharmaceutical bulletin 20080801

• Comparison of analytical and theoretical pharmaceutical concentrations in human urine in Germany.

  Water research 20080801

• 1-Acetyl-3-(4-chloro-phen-yl)-5-(4-fluoro-phen-yl)-2-pyrazoline.

  Acta crystallographica. Section E, Structure reports online 20080801

• 1,1',5,5'-Tetra-methyl-2,2'-diphenyl-4,4'-[p-phenyl-enebis(methyl-idynenitrilo)]di-1H-pyrazol-3(2H)-one.

  Acta crystallographica. Section E, Structure reports online 20080801

• 2,3,4-Trihydroxy-benzaldehyde.

  Acta crystallographica. Section E, Structure reports online 20080801

• 5-Hydr-oxy-1-(3-hydr-oxy-2-naphtho-yl)-3,5-dimethyl-2-pyrazoline.

  Acta crystallographica. Section E, Structure reports online 20080801

• 1-[3-(2-Naphth-yl)-5-(3,4,5-trimethoxy-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

  Acta crystallographica. Section E, Structure reports online 20080801

• A novel design of artificial membrane for improving the PAMPA model.

  Pharmaceutical research 20080701

• Microdosing assessment to evaluate pharmacokinetics and drug metabolism in rats using liquid chromatography-tandem mass spectrometry.

  Pharmaceutical research 20080701

• Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(L-lactic acid) microspheres in healthy pigs.

  European journal of nuclear medicine and molecular imaging 20080701

• Edaravone (MCI-186), a free radical scavenger, attenuates retinal ischemia/reperfusion injury in rats.

  Acta pharmacologica Sinica 20080701

• Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol.

  Journal of neurotrauma 20080701

• [Multi-center survey of edaravone treatment in children].

  No to hattatsu = Brain and development 20080701

• Administration of free radical scavenger edaravone associated with higher frequency of hemorrhagic transformation in patients with cardiogenic embolism.

  Neurologia medico-chirurgica 20080701

• [Synthesis of new blue pyrazoline fluorescent compounds and study of infrared spectroscopy].

  Guang pu xue yu guang pu fen xi = Guang pu 20080701

• Dibromidobis-(4-hydr-oxy-1,5-dimethyl-2-phenyl-3-pyrazolone)zinc(II).

  Acta crystallographica. Section E, Structure reports online 20080701

• 3,5-Bis[1-acetyl-5-(4-chloro-phen-yl)-4,5-dihydro-1H-pyrazol-3-yl]-2,6-dimethyl-pyridine tetra-hydro-furan solvate.

  Acta crystallographica. Section E, Structure reports online 20080701

• Zinc-catalyzed synthesis of pyrazolines and pyrazoles via hydrohydrazination.

  Organic letters 20080619

• Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

  Journal of medicinal chemistry 20080612

• Mild hepatitis at recommended doses of acetaminophen in patients with evidence of constitutionally enhanced cytochrome P450 system activity.

  Journal of clinical pharmacy and therapeutics 20080601

• Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model.

  Prenatal diagnosis 20080601

• In vitro metabolism study of edaravone in Wistar and hairless rat skin.

  Biological & pharmaceutical bulletin 20080601

• Aroylethenesulfonylacetic acid methyl ester: a synthon for novel sulfone linked bis heterocycles.

  Chemical & pharmaceutical bulletin 20080601

• 1,5-Dimethyl-4-[(5-methyl-2-furyl)-methyl-ene-amino]-2-phenyl-1H-pyrazol-3(2H)-one.

  Acta crystallographica. Section E, Structure reports online 20080601

• Cholecystokinin antagonists (part 1): Antinociceptive, anxiolytic and antidepressant effects of N-(5-methyl-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazol-4-yl)-N'-phenylureas and carboxamides.

  Drug discoveries & therapeutics 20080601

• Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats.

  European journal of pharmacology 20080531

• Environmentally relevant concentrations of pharmaceuticals influence the initial adhesion of bacteria.

  Aquatic toxicology (Amsterdam, Netherlands) 20080530

• Edaravone prevents kainic acid-induced neuronal death.

  Brain research 20080513

• Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver.

  Pharmaceutical research 20080501

• Inhibition of placental P-glycoprotein: impact on indinavir transfer to the foetus.

  British journal of clinical pharmacology 20080501

• Bioactivation of a dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide) scaffold to a putative p-chlorophenyl isocyanate in rat liver microsomes and in vivo in rats.

  Chemical research in toxicology 20080501

• [From the plant to chemistry--the early history of 'rheumatic medication'].

  Zeitschrift fur Rheumatologie 20080501

• Inhibition of neointimal hyperplasia development by MCI-186 is correlated with downregulation of nuclear factor-kappaB pathway.

  Circulation journal : official journal of the Japanese Circulation Society 20080501

• [Case of transient cortical blindness due to thrombosis of the transverse sinus].

  Rinsho shinkeigaku = Clinical neurology 20080501

• [Protective effects of edaravone on renal ischemia-reperfusion injury in rats].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20080501

• Synthesis and biological activity of some new pyrazoline and pyrrolo[3,4-c]pyrazole-4,6-dione derivatives: reaction of nitrilimines with some dipolarophiles.

  Molecules (Basel, Switzerland) 20080429

• Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat.

  Pharmaceutical research 20080401

• Treatment of yellow fever.

  Antiviral research 20080401

• Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model.

  Drug metabolism and disposition: the biological fate of chemicals 20080401

• Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.

  Bioorganic & medicinal chemistry 20080401

• Behaviour and redox sensitivity of pharmaceutical residues during bank filtration - Investigation of residues of phenazone-type analgesics.

  Chemosphere 20080401

• 1-Acetyl-3-ferrocenyl-5-(2-nitro-phen-yl)-2-pyrazoline.

  Acta crystallographica. Section E, Structure reports online 20080401

• The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice.

  European journal of pharmacology 20080331

• Flattened cortical maps of cerebral function in the rat: a region-of-interest approach to data sampling, analysis and display.

  Neuroscience letters 20080328

• Photoinduced electron transfer in coaggregates of dicyanonaphthalene and pyrazoline.

  The journal of physical chemistry. A 20080320

• A flow sensitive alternating inversion recovery (FAIR)-MRI protocol to measure hemispheric cerebral blood flow in a mouse stroke model.

  Experimental neurology 20080301

• Edaravone prevents iNOS expression by inhibiting its promoter transactivation and mRNA stability in cytokine-stimulated hepatocytes.

  Nitric oxide : biology and chemistry 20080301

• Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20080301

• Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.

  The AAPS journal 20080301

• 4-[(5R*,10bR*)-2-Methyl-1,10b-dihydro-pyrazolo[1,5-c][1,3]benzoxazin-5-yl]benzoic acid.

  Acta crystallographica. Section E, Structure reports online 20080301

• Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.

  Brain research 20080208

• Novel Pd(II) complexes of 1-N-substituted 3-phenyl-2-pyrazoline derivatives and evaluation of antiamoebic activity.

  European journal of medicinal chemistry 20080201

• The radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) reacts with a pterin derivative and produces a cytotoxic substance that induces intracellular reactive oxygen species generation and cell death.

  The Journal of pharmacology and experimental therapeutics 20080201

• Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage.

  Stroke 20080201

• Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.

  Anti-cancer drugs 20080201

• Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents.

  Bioorganic & medicinal chemistry letters 20080201

• A program of anticipatory guidance for the prevention of emergency department visits for ear pain.

  Archives of pediatrics & adolescent medicine 20080201

• Otitis media, shared decision making, and enhancing value in pediatric practice.

  Archives of pediatrics & adolescent medicine 20080201

• Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.

  Journal of chromatographic science 20080201

• Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model.

  European journal of obstetrics, gynecology, and reproductive biology 20080101

• Edaravone inhibits collagen-induced arthritis possibly through suppression of nuclear factor-kappa B.

  Molecular immunology 20080101

• Spontaneous resolution of isolated dissecting aneurysm on the posterior inferior cerebellar artery.

  Acta neurochirurgica 20080101

• The conversion of chicken manure to bio-oil by fast pyrolysis. III. Analyses of chicken manure, bio-oils and char by Py-FIMS and Py-FDMS.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20080101

• Transfer of methadone across the dually perfused preterm human placental lobule.

  American journal of obstetrics and gynecology 20080101

• Free drug metabolic clearance in elderly people.

  Clinical pharmacokinetics 20080101

• Dihydroartemisinin potentiates the cytotoxic effect of temozolomide in rat C6 glioma cells.

  Pharmacology 20080101

• The novel antioxidant edaravone: from bench to bedside.

  Cardiovascular therapeutics 20080101

• Synthesis of some new quinazolin-4-one derivatives and evaluation of their antimicrobial and antiinflammatory effects.

  Acta poloniae pharmaceutica 20080101

• The metabolism and transplacental transfer of oseltamivir in the ex vivo human model.

  Infectious diseases in obstetrics and gynecology 20080101

• Edaravone improves the survival of rats subjected to hemorrhagic shock without resuscitation.

  Surgery today 20080101

• Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons.

  BMC neuroscience 20080101

• Reactive oxygen species generation through NADH oxidation by pterin derivatives.

  Nucleic acids symposium series (2004) 20080101

• Removal of selected pharmaceuticals by chlorination, coagulation-sedimentation and powdered activated carbon treatment.

  Water science and technology : a journal of the International Association on Water Pollution Research 20080101

• Combination drug therapy using edaravone and Daio-Orengedoku-to after transient focal ischemia in rats.

  Methods and findings in experimental and clinical pharmacology 20080101

• Internal carotid artery occlusion manifesting only as oculomotor nerve palsy.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20080101

• Novel treatments for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

  Acta neurochirurgica. Supplement 20080101

• Antioxidants and neuroprotection in the adult and developing central nervous system.

  Current medicinal chemistry 20080101

• Antiinflammatory, analgesic and antipyretic activity of certain thiazolidinones.

  Indian journal of pharmaceutical sciences 20080101

• Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents.

  Indian journal of pharmaceutical sciences 20080101

• Benzyl 5-ferrocenyl-3-(4-methyl-phen-yl)-2-pyrazoline-1-dithio-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20080101

• Synthesis and Activity Evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles.

  Indian journal of pharmaceutical sciences 20080101

• Calibration in non-linear NIR spectroscopy using principal component artificial neural networks.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071231

• Discovery of metaflumizone, a novel semicarbazone insecticide.

  Veterinary parasitology 20071215

• Use of elevated flow rates in preparative subcritical fluid chromatography.

  Journal of chromatography. A 20071214

• Reorganization of functional brain maps after exercise training: Importance of cerebellar-thalamic-cortical pathway.

  Brain research 20071212

• A novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat focal cerebral ischemia.

  Brain research 20071205

• Soluble epoxide hydrolase: a novel therapeutic target in stroke.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20071201

• Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia.

  Neuroscience research 20071201

• Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats.

  Journal of gastroenterology and hepatology 20071201

• Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance.

  Clinical and experimental nephrology 20071201

• [Epileptogenic and non-epileptogenic zones: blood flow studies of temporo-limbic seizures].

  Revue neurologique 20071201

• Multiple N-methylation by a designed approach enhances receptor selectivity.

  Journal of medicinal chemistry 20071129

• Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability.

  Journal of medicinal chemistry 20071129

• Concurrent determination of topotecan and model permeability markers (atenolol, antipyrine, propranolol and furosemide) by reversed phase liquid chromatography: utility in Caco-2 intestinal absorption studies.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115

• Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one).

  Journal of photochemistry and photobiology. B, Biology 20071112

• Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats.

  Digestive diseases and sciences 20071101

• Investigation of the behavior and metabolism of pharmaceutical residues during purification of contaminated ground water used for drinking water supply.

  Chemosphere 20071101

• Evaluation of the role of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one).

  Drug metabolism and disposition: the biological fate of chemicals 20071101

• Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells.

  American journal of physiology. Cell physiology 20071101

• Design, synthesis, and biological testing of pyrazoline derivatives of combretastatin-A4.

  Bioorganic & medicinal chemistry letters 20071101

• Protective effect of edaravone against endolymphatic hydrops.

  Acta oto-laryngologica 20071101

• Edaravone, a potent free radical scavenger, prevents anthracycline-induced myocardial cell death.

  Circulation journal : official journal of the Japanese Circulation Society 20071101

• Free radical scavenger edaravone suppresses x-ray-induced apoptosis through p53 inhibition in MOLT-4 cells.

  Journal of radiation research 20071101

• Study on the fluorescence properties of a new intramolecular charge transfer compound 1,5-diphenyl-3-(N-ethylcarbazole-3-yl)-2-pyrazoline.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071001

• Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger.

  Glia 20071001

• MCI-186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling.

  Journal of neuroscience research 20071001

• Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats.

  Neurotoxicity research 20071001

• Effect of synthetic dermorphin analogues on tissue homeostasis in the myocardium of newborn albino rats.

  Bulletin of experimental biology and medicine 20071001

• Effect of sedatin (synthetic dermorphin analog) on the development of Acipenser schrenckii young fish.

  Bulletin of experimental biology and medicine 20071001

• Polymer mobilization and drug release during tablet swelling. A 1H NMR and NMR microimaging study.

  Journal of controlled release : official journal of the Controlled Release Society 20070926

• Placental transfer of quetiapine in relation to P-glycoprotein activity.

  Journal of psychopharmacology (Oxford, England) 20070901

• A minimal physiological model of thiopental distribution kinetics based on a multiple indicator approach.

  Drug metabolism and disposition: the biological fate of chemicals 20070901

• Maternal-fetal transport kinetics of carboplatin in the perfused human placental lobule: in vitro study.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20070901

• [Degradation mechanism and efficiency of organic pollutants of landfill leachate in different redox zones].

  Huan jing ke xue= Huanjing kexue 20070901

• Mechanisms for the effect of arginine-containing dermorphin analogue on proliferative processes in the gastric mucosa of albino rats.

  Bulletin of experimental biology and medicine 20070901

• Antipyrine clearance in comparison to conventional liver function tests in hepatitis C virus patients.

  European journal of pharmacology 20070827

• The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress.

  Neuroscience letters 20070823

• Design, synthesis, and in vivo SAR of a novel series of pyrazolines as potent selective androgen receptor modulators.

  Journal of medicinal chemistry 20070809

• Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate.

  Drug metabolism and disposition: the biological fate of chemicals 20070801

• Comparative disposition of pharmacologic markers for cytochrome P-450 mediated metabolism, glomerular filtration rate, and extracellular and total body fluid volume of Greyhound and Beagle dogs.

  Journal of veterinary pharmacology and therapeutics 20070801

• [From willow bark to the coxibs. Development of antiphlogistic analgesics].

  Schmerz (Berlin, Germany) 20070801

• Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo.

  Journal of pharmacological sciences 20070801

• Decreased intestinal CYP3A and P-glycoprotein activities in rats with adjuvant arthritis.

  Drug metabolism and pharmacokinetics 20070801

• Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy.

  European journal of pharmacology 20070730

• Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.

  The Journal of pharmacology and experimental therapeutics 20070701

• Differential inhibition by oxygen radicals of vasoactive amines-induced contractions in the porcine coronary artery.

  Biological & pharmaceutical bulletin 20070701

• Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients.

  Radiation medicine 20070701

• QSAR study on permeability of hydrophobic compounds with artificial membranes.

  Bioorganic & medicinal chemistry 20070601

• A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20070601

• Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts.

  The Journal of thoracic and cardiovascular surgery 20070601

• Quantitative liver functions in Turner syndrome with and without hormone replacement therapy.

  European journal of endocrinology 20070601

• 3-(4-Bromophenyl)-5-(4-dimethylaminophenyl)-1-phenyl-2-pyrazoline: X-ray and density functional theory (DFT) studies.

  Acta crystallographica. Section C, Crystal structure communications 20070601

• Synthesis and antitubercular activity of substituted novel pyrazoline derivatives.

  Natural product research 20070601

• Toxicity of diazinon and its metabolites increases in diabetic rats.

  Toxicology letters 20070515

• Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta.

  Drug metabolism and disposition: the biological fate of chemicals 20070501

• Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger.

  Journal of pharmacological sciences 20070501

• Effect of edaravone, a free radical scavenger, on ischemic cerebral edema assessed by magnetic resonance imaging.

  Neurologia medico-chirurgica 20070501

• Maternal-fetal transport kinetics of methotrexate in perfused human placenta: in vitro study.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20070501

• Cortical contusion induces trans-hemispheric reorganization of blood flow maps.

  Brain research 20070413

• Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis.

  Atherosclerosis 20070401

• Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.

  Cell death and differentiation 20070401

• Circulatory transport and capillary-tissue exchange as determinants of the distribution kinetics of inulin and antipyrine in dog.

  Journal of pharmaceutical sciences 20070401

• Granulocyte-macrophage colony-stimulating factor-induced vessel growth restores cerebral blood supply after bilateral carotid artery occlusion.

  Stroke 20070401

• Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain.

  Journal of pharmacological sciences 20070401

• Melatonin influences the proliferative and differentiative activity of neural stem cells.

  Journal of pineal research 20070401

• Simultaneous determination of paracetamol, caffeine and propyphenazone in ternary mixtures by micellar electrokinetic capillary chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301

• Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction.

  The Journal of thoracic and cardiovascular surgery 20070301

• Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury.

  Biological & pharmaceutical bulletin 20070301

• Urgent endarterectomy using pretreatment with free radical scavenger, edaravone, and early clamping of the parent arteries for cervical carotid artery stenosis with crescendo transient ischemic attacks caused by mobile thrombus and hemodynamic cerebral ischemia. Case report.

  Neurologia medico-chirurgica 20070301

• Edaravone inhibits lipid peroxidation in neonatal hypoxic-ischemic rats: an in vivo microdialysis study.

  Neuroscience letters 20070227

• Synthesis, structural activity relationship and anti-tubercular activity of novel pyrazoline derivatives.

  European journal of medicinal chemistry 20070201

• Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?

  Antioxidants & redox signaling 20070201

• Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening.

  Toxicology in vitro : an international journal published in association with BIBRA 20070201

• Silicone rod extraction of pharmaceuticals from water.

  Analytical and bioanalytical chemistry 20070201

• Development of a multicommuted flow-through optosensor for the determination of a ternary pharmaceutical mixture.

  Journal of pharmaceutical and biomedical analysis 20070117

• Edaravone protects the vestibular periphery from free radical-induced toxicity in response to perilymphatic application of (+/-)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid.

  European journal of pharmacology 20070112

• Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.

  Brain research 20070112

• Edaravone reduces ischemia-reperfusion injury mediators in rat liver.

  The Journal of surgical research 20070101

• The specific free radical scavenger edaravone suppresses bleomycin-induced acute pulmonary injury in rabbits.

  Clinical and experimental pharmacology & physiology 20070101

• Effects of edaravone on singlet oxygen released from activated human neutrophils.

  Journal of pharmacological sciences 20070101

• A novel reaction of the 'Huisgen zwitterion' with chalcones and dienones: an efficient strategy for the synthesis of pyrazoline and pyrazolopyridazine derivatives.

  Angewandte Chemie (International ed. in English) 20070101

• Alfentanil-induced miosis as a surrogate measure of alfentanil pharmacokinetics in patients with mild and moderate liver cirrhosis.

  Clinical pharmacokinetics 20070101

• Hydroxyl radical mediates the augmented angiotensin II responses in thoracic aorta of spontaneously hypertensive rats.

  Pharmacology 20070101

• Structure-based modelling in reproductive toxicology: (Q)SARs for the placental barrier.

  SAR and QSAR in environmental research 20070101

• Determination of the analgesic components of Spasmomigraine tablet by liquid chromatography with ultraviolet detection.

  Journal of AOAC International 20070101

• An improved synthesis of 1,3,5-triaryl-2-pyrazolines in acetic acid aqueous solution under ultrasound irradiation.

  Beilstein journal of organic chemistry 20070101

• Interaction of rat lung SSAO with the novel 1-N-substituted thiocarbamoyl-3-substituted phenyl-5-(2-pyrolyl)-2-pyrazoline derivatives.

  Journal of neural transmission (Vienna, Austria : 1996) 20070101

• Effects of MCI-186 upon neutrophil-derived active oxygens.

  Redox report : communications in free radical research 20070101

• Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux.

  Clinical pharmacokinetics 20070101

• Development and validation of chemometrics-assisted spectrophotometry and liquid chromatography methods for the simultaneous determination of the active ingredients in two multicomponent mixtures containing chlorpheniramine maleate and phenylpropanolamine hydrochloride.

  Journal of AOAC International 20070101

• Antiarrhythmics: elimination and dosage considerations in hepatic impairment.

  Clinical pharmacokinetics 20070101

• [Oxidative stress and hepatic monooxygenase function in patients with coronary heart disease before and after cardiac surgery].

  Anesteziologiia i reanimatologiia 20070101

• Transition metal complexes of quinolino[3,2-b]benzodiazepine and quinolino[3,2-b]benzoxazepine: synthesis, characterization, and antimicrobial studies.

  Bioinorganic chemistry and applications 20070101

• Folate during reproduction: the Canadian experience with folic acid fortification.

  Nutrition research and practice 20070101

• Targeting receptors, transporters and site of absorption to improve oral drug delivery.

  Drug target insights 20070101

• Spectrophotometric study of the charge-transfer complexes of iodine with antipyrine in organic solvents.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061201

• Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis.

  Journal of neurophysiology 20061201

• Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base.

  Bioorganic & medicinal chemistry letters 20061201

• Physiologically based synthetic models of hepatic disposition.

  Journal of pharmacokinetics and pharmacodynamics 20061201

• Anterior and posterior inferior cerebellar artery infarction with sudden deafness and vertigo.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20061201

• Chiral resolution of monosaccharides as 1-phenyl-3-methyl-5-pyrazolone derivatives by ligand-exchange CE using borate anion as a central ion of the chiral selector.

  Electrophoresis 20061201

• Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice.

  Acta pharmacologica Sinica 20061201

• Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study).

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20061201

• Protective effect of radical scavenger edaravone against puromycin nephrosis.

  Clinical nephrology 20061201

• Long-term comparison of trace organics removal performances between conventional and membrane activated sludge processes.

  Water environment research : a research publication of the Water Environment Federation 20061201

• Synthesis and characterization of pseudo-affinity ligand for penicillin acylase purification.

  International journal of biological macromolecules 20061115

• Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20061101

• Evaluation of cocktail approach to standardise Caco-2 permeability experiments.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061101

• Edaravone reduces myocardial infarct size and improves cardiac function and remodelling in rabbits.

  Clinical and experimental pharmacology & physiology 20061101

• [Electron spin resonance method and brain diseases].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20061101

• Alkoxyl radical-scavenging activity of edaravone in patients with traumatic brain injury.

  Journal of neurotrauma 20061101

• Modeling seasonal redox dynamics and the corresponding fate of the pharmaceutical residue phenazone during artificial recharge of groundwater.

  Environmental science & technology 20061101

• Effect of antipyrine on the gastric emptying of liquid in rats.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20061101

• [Easing pain in palliative care and death with dignity-euthanasia].

  Masui. The Japanese journal of anesthesiology 20061101

• [Edaravone].

  Nihon rinsho. Japanese journal of clinical medicine 20061028

• Synthesis and in vitro antitumor evaluation of some indeno[1,2-c]pyrazol(in)es substituted with sulfonamide, sulfonylurea(-thiourea) pharmacophores, and some derived thiazole ring systems.

  Bioorganic & medicinal chemistry 20061001

• Transfer of metformin across the dually perfused human placental lobule.

  American journal of obstetrics and gynecology 20061001

• Permeability assessment of poorly water-soluble compounds under solubilizing conditions: the reciprocal permeability approach.

  Journal of pharmaceutical sciences 20061001

• Synthesis, structure, and in vitro antitumor activity of some glycoside derivatives of ferrocenyl-chalcones and ferrocenyl-pyrazolines.

  ChemMedChem 20061001

• Effects of edaravone on N-methyl-D-aspartate (NMDA)-mediated cytochrome c release and apoptosis in neonatal rat cerebrocortical slices.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20061001

• The therapeutic efficacy of edaravone in extensively burned rats.

  Archives of surgery (Chicago, Ill. : 1960) 20061001

• MCI-186 administered to the maternal circulation inhibits fetal brain injury resulting from total umbilical cord occlusion in the chronically instrumented fetal lamb.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20061001

• Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species.

  Brain research 20060907

• The action of urocortins on body temperature in rats.

  Peptides 20060901

• Modulation of antipyrine clearance by polysaccharide peptide (PSP) isolated from Coriolus versicolor in the rat.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060901

• Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria.

  Journal of Zhejiang University. Science. B 20060901

• Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice.

  Circulation journal : official journal of the Japanese Circulation Society 20060901

• Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model.

  Transplantation proceedings 20060901

• Effect of human serum albumin on transplacental transfer of glyburide.

  Biochemical pharmacology 20060828

• Membrane-assisted liquid-liquid extraction coupled with gas chromatography-mass spectrometry for determination of selected polycyclic musk compounds and drugs in water samples.

  Journal of chromatography. A 20060818

• Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum.

  European journal of pharmacology 20060807

• Transit time dispersion in pulmonary and systemic circulation: effects of cardiac output and solute diffusivity.

  American journal of physiology. Heart and circulatory physiology 20060801

• Estrogenic activity of pharmaceuticals and pharmaceutical mixtures in a yeast reporter gene system.

  Reproductive toxicology (Elmsford, N.Y.) 20060801

• MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) attenuated simulated ischemia/reperfusion injury in cultured rat hippocampal cells.

  Biological & pharmaceutical bulletin 20060801

• Primary sclerosing cholangitis: correlation of hepatobiliary scintigraphy with clinical and laboratory status.

  Australasian radiology 20060801

• Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060801

• Hyperbaric oxygen combined with intravenous edaravone for treatment of acute embolic stroke: a pilot clinical trial.

  Neurologia medico-chirurgica 20060801

• Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats.

  Pharmacological research 20060701

• First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model.

  Drug metabolism and disposition: the biological fate of chemicals 20060701

• Development of an in vitro rat intestine segmental perfusion model to investigate permeability and predict oral fraction absorbed.

  Pharmaceutical research 20060701

• Long-term efficacy of edaravone in patients with acute myocardial infarction.

  Circulation journal : official journal of the Japanese Circulation Society 20060701

• Protective effect of edaravone in inner-ear barotrauma in guinea pigs.

  The Journal of laryngology and otology 20060701

• Persistent cerebrovascular effects of MDMA and acute responses to the drug.

  The European journal of neuroscience 20060701

• Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.

  Journal of medicinal chemistry 20060629

• Novel bis(1-acyl-2-pyrazolines) of potential anti-inflammatory and molluscicidal properties.

  Bioorganic & medicinal chemistry 20060601

• Synthesis of some new testosterone derivatives fused with substituted pyrazoline ring as promising 5alpha-reductase inhibitors.

  Acta pharmaceutica (Zagreb, Croatia) 20060601

• Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage.

  Free radical research 20060601

• What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine.

  Drug metabolism and pharmacokinetics 20060601

• [Advanced medical therapy in patients with acute ischemic stroke].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060601

• Novel synthesis of highly functionalized pyrazolines and pyrazoles by triphenylphosphine-mediated reaction of dialkyl azodicarboxylate with allenic esters.

  Organic letters 20060525

• The involvement of a cyclooxygenase 1 gene-derived protein in the antinociceptive action of paracetamol in mice.

  European journal of pharmacology 20060524

• Synthesis, characterization and antiamoebic activity of 1-(thiazolo[4,5-b]quinoxaline-2-yl)-3-phenyl-2-pyrazoline derivatives.

  Bioorganic & medicinal chemistry letters 20060515

• An antioxidant treatment potentially protects myocardial energy metabolism by regulating uncoupling protein 2 expression in a chronic beta-adrenergic stimulation rat model.

  Life sciences 20060515

• Optimal window for ictal blood flow mapping. Insight from the study of discrete temporo-limbic seizures in rats.

  Epilepsy research 20060501

• Specific modification of peptide-bound citrulline residues.

  Analytical biochemistry 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations.

  The Journal of pharmacy and pharmacology 20060501

• Apoptosis in ischemic spinal cord injury.

  The Journal of thoracic and cardiovascular surgery 20060501

• The free-radical scavenger, edaravone, augments NO release from vascular cells and platelets after laser-induced, acute endothelial injury in vivo.

  Platelets 20060501

• High-performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestinal permeability studies using timed wavelength detection.

  Biomedical chromatography : BMC 20060401

• A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia.

  American journal of physiology. Heart and circulatory physiology 20060401

• [Microsomal oxidative metabolism in the liver of rats treated with vinorelbine: evaluation through antipyrine elimination].

  Gastroenterologia y hepatologia 20060401

• Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats.

  Biological & pharmaceutical bulletin 20060401

• Patient age is a strong independent predictor of 13C-aminopyrine breath test results: a comparative study with histology, duplex-Doppler and a laboratory index in patients with chronic hepatitis C virus infection.

  Clinical and experimental pharmacology & physiology 20060401

• Validation of a new high-performance liquid chromatography assay for nizatidine.

  Therapeutic drug monitoring 20060401

• Edaravone inhibits the disease activity in rheumatoid arthritis.

  Journal of clinical pharmacy and therapeutics 20060401

• Comparison of the percutaneous absorption of hydrophilic and lipophilic compounds in shed snake skin and human skin.

  Die Pharmazie 20060401

• Quantitative structure-pharmacokinetic relationships for drug clearance by using statistical learning methods.

  Journal of molecular graphics & modelling 20060301

• MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060301

• Synthesis and evaluation of N-(3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-1H-indole-carboxamides as cholecystokinin antagonists.

  The Journal of pharmacy and pharmacology 20060301

• Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion.

  Heart and vessels 20060301

• [Homeostatic conditions affect the protective effect of edaravone on ischemic injury in neurons].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060301

• Synthesis and molecular modelling of novel substituted-4,5-dihydro-(1H)-pyrazole derivatives as potent and highly selective monoamine oxidase-A inhibitors.

  Chemical biology & drug design 20060301

• Inhibition of human neutrophil oxidative burst by pyrazolone derivatives.

  Free radical biology & medicine 20060215

• Functionalized magnesium organometallics as versatile intermediates for the synthesis of polyfunctional heterocycles.

  Chemical communications (Cambridge, England) 20060214

• Mobility of pharmaceuticals carbamazepine, diclofenac, ibuprofen, and propyphenazone in miscible-displacement experiments.

  Journal of contaminant hydrology 20060201

• Edaravone inhibits rheumatoid synovial cell proliferation and migration.

  Free radical research 20060201

• The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice.

  International journal of molecular medicine 20060201

• The production of hydroxyl radicals in the fetal lamb brain resulting from occlusion of the umbilical circulation and the transplacental effect of MCI-186 to inhibit hydroxyl radical production.

  Pediatric research 20060201

• Synthetic studies on erythromycin derivatives: reactivity of the C12-21 alkene.

  Molecules (Basel, Switzerland) 20060131

• A porcine model for fixed drug eruptions in humans: the case of antipyrine in the Yucatan micropig.

  Journal of applied toxicology : JAT 20060101

• Protective effect of edaravone against the ototoxicity of Pseudomonas aeruginosa exotoxin A.

  Acta oto-laryngologica 20060101

• Influences of drugs on the oxygen uptake rate and biosorption of activated sludge.

  Biological & pharmaceutical bulletin 20060101

• Edaravone diminishes free radicals from circulating neutrophils in patients with ischemic brain attack.

  Internal medicine (Tokyo, Japan) 20060101

• Maternal-fetal transport and disposition of copper, iron, molybdenum, selenium and zinc in experimentally induced diabetic rats.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20060101

• Reactive oxygen species generated by mitochondrial injury in human brain microvessel endothelial cells.

  Clinical hemorheology and microcirculation 20060101

• Edaravone in acute ischemic stroke.

  Internal medicine (Tokyo, Japan) 20060101

• Efficacy of edaravone in cardioembolic stroke.

  Internal medicine (Tokyo, Japan) 20060101

• [Gilbert's syndrome: a clinicogenetic trial].

  Terapevticheskii arkhiv 20060101

• New modalities for the treatment of acute cardioembolic stroke.

  Internal medicine (Tokyo, Japan) 20060101

• Synthesis, biological evaluation and 3D-QSAR of 1,3,5-trisubstituted-4,5-dihydro-(1H)-pyrazole derivatives as potent and highly selective monoamine oxidase A inhibitors.

  Current medicinal chemistry 20060101

• Morphological regeneration and hepatic functional mass after right hemihepatectomy.

  Digestive surgery 20060101

• Antimicrobial and toxicological evaluation of the leaves of Baissea axillaries Hua used in the management of HIV/AIDS patients.

  BMC complementary and alternative medicine 20060101

• Dipyrone and aminopyrine are effective scavengers of reactive nitrogen species.

  Redox report : communications in free radical research 20060101

• [The clinicobiological status of patients with pulmonary tuberculosis concurrent with chronic hepatitis B and/or C].

  Problemy tuberkuleza i boleznei legkikh 20060101

• Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury.

  CNS drug reviews 20060101

• Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach.

  Arthritis research & therapy 20060101

• Cardioprotective effect of edaravone against ischaemia-reperfusion injury in the rabbit heart before, during and after reperfusion treatment.

  The Journal of international medical research 20060101

• Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases.

  Recent patents on cardiovascular drug discovery 20060101

• Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure.

  Circulation 20051206

• Dielectric relaxation spectroscopy of heteronuclear cobalt(II)-copper(II) complex of 1-phenyl-3-methyl-5-pyrazolone.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051201

• MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats.

  American journal of physiology. Heart and circulatory physiology 20051201

• Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention.

  The Journal of pharmacology and experimental therapeutics 20051201

• Experimental study on the protective effects of edaravone against ischemic spinal cord injury.

  The Journal of thoracic and cardiovascular surgery 20051201

• Transfer of meropenem in the ex vivo human placenta perfusion model.

  Infectious diseases in obstetrics and gynecology 20051201

• Comparative application of wavelet approaches to absorption and ratio spectra for the simultaneous determination of diminazene aceturate and phenazone in veterinary granules for injection.

  Die Pharmazie 20051201

• Prediction of absorbability of poorly water-soluble drugs based on permeability obtained through modified in vitro chamber method.

  Drug metabolism and pharmacokinetics 20051201

• Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs.

  Journal of controlled release : official journal of the Controlled Release Society 20051128

• Effects of nicotine-specific antibodies, Nic311 and Nic-IgG, on the transfer of nicotine across the human placenta.

  Biochemical pharmacology 20051125

• The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB.

  Cancer letters 20051118

• Region-dependent role of the mucous/glycocalyx layers in insulin permeation across rat small intestinal membrane.

  Pharmaceutical research 20051101

• Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy.

  Stroke 20051101

• A free radical scavenger, edaravone, inhibits lipid peroxidation and the production of nitric oxide in hypoxic-ischemic brain damage of neonatal rats.

  American journal of obstetrics and gynecology 20051101

• Synthesis of new 2-thiouracil-5-sulphonamide derivatives with antibacterial and antifungal activity.

  Archives of pharmacal research 20051101

• Death of an infant involving benzocaine.

  Journal of forensic sciences 20051101

• Post-exposure administration of edaravone attenuates noise-induced hearing loss.

  European journal of pharmacology 20051017

• Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction.

  Free radical biology & medicine 20051015

• Heterocyclic ring scaffolds as small-molecule cholesterol absorption inhibitors.

  Organic & biomolecular chemistry 20051007

• Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats.

  Pediatric nephrology (Berlin, Germany) 20051001

• 4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.

  Bioorganic & medicinal chemistry letters 20051001

• Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain.

  Stroke 20051001

• Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy.

  Surgical neurology 20051001

• Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder.

  Urology 20051001

• Analysis of the monosaccharide components in Angelica polysaccharides by high performance liquid chromatography.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20051001

• Protective effect of a radical scavenger, MCI-186 on islet cell damages induced by oxidative stress.

  Transplantation proceedings 20051001

• [Bilateral multiple border zone infarctions after massive bleeding: report of two cases].

  Rinsho shinkeigaku = Clinical neurology 20051001

• 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines: synthesis and in vitro antiamoebic activities.

  European journal of medicinal chemistry 20050901

• Use of nonlinear mixed effect modeling for the intestinal absorption data: application to ritonavir in the rat.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050901

• Oxidation of pharmaceuticals during water treatment with chlorine dioxide.

  Water research 20050901

• Pharmacokinetic and pharmacodynamic factors that can affect sensitivity to neurotoxic sequelae in elderly individuals.

  Environmental health perspectives 20050901

• Two N-substituted 3,5-diphenyl-2-pyrazoline-1-thiocarboxamides.

  Acta crystallographica. Section C, Crystal structure communications 20050901

• Transfer of ciprofloxacin, ofloxacin and levofloxacin across the perfused human placenta in vitro.

  European journal of obstetrics, gynecology, and reproductive biology 20050901

• The role of edaravone on the impairment of endothelial barrier function induced by acute oxidative stress in cultured human umbilical vein endothelial cell monolayer.

  The Journal of trauma 20050901

• Excipient effects on gastrointestinal transit and drug absorption in beagle dogs.

  International journal of pharmaceutics 20050826

• Antipyrine test predicts pharmacodynamics in docetaxel and cisplatin combination chemotherapy.

  Lung cancer (Amsterdam, Netherlands) 20050801

• Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity.

  Journal of neurochemistry 20050801

• Time course and mapping of cerebral perfusion during amygdala secondarily generalized seizures.

  Epilepsia 20050801

• Effect of the free radical scavenger MCI-186 on spinal cord reperfusion after transient ischemia in the rabbit.

  The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20050801

• A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation.

  Transplantation 20050727

• Synthesis and structure of cyclopropano-annelated homosesquinorbornene derivatives containing pyramidalized double bonds: evidence for the sterical effect of a cyclopropyl group on the degree of C=C double-bond pyramidalization.

  The Journal of organic chemistry 20050708

• Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

  Journal of pharmaceutical sciences 20050701

• MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats.

  Transplant international : official journal of the European Society for Organ Transplantation 20050701

• Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat.

  Journal of cardiovascular pharmacology 20050701

• Lack of antiapoptotic effects of antiplatelet drug, aspirin and clopidogrel, and antioxidant, MCI-186, against focal ischemic brain damage in rats.

  Neurological research 20050701

• Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model.

  Neurological research 20050701

• Restoration of cerebral vasoreactivity by an L-type calcium channel blocker following fluid percussion brain injury.

  Journal of neurotrauma 20050701

• Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction.

  Neurologia medico-chirurgica 20050701

• Role of the mucous/glycocalyx layers in insulin permeation across the rat ileal membrane.

  International journal of pharmaceutics 20050613

• Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats.

  European journal of pharmacology 20050601

• Comparison of data obtained from sedated versus unsedated wireless telemetry capsule placement: does sedation affect the results of ambulatory 48-hour pH testing?

  The Laryngoscope 20050601

• State-dependent block of rat Nav1.4 sodium channels expressed in xenopus oocytes by pyrazoline-type insecticides.

  Neurotoxicology 20050601

• Phenylobacterium falsum sp. nov., an Alphaproteobacterium isolated from a nonsaline alkaline groundwater, and emended description of the genus Phenylobacterium.

  Systematic and applied microbiology 20050601

• [A case of stroke-like episode of MELAS of which progressive spread would be prevented by edaravone].

  Rinsho shinkeigaku = Clinical neurology 20050601

• Neuroprotection and enhanced recovery with edaravone after acute spinal cord injury in rats.

  Spine 20050515

• High performance liquid chromatographic determination of N-butyryl glucosamine in rat plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

• Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

  Journal of medicinal chemistry 20050505

• Cyclooxygenase-2 is an obligatory factor in methamphetamine-induced neurotoxicity.

  The Journal of pharmacology and experimental therapeutics 20050501

• The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy.

  Hypertension (Dallas, Tex. : 1979) 20050501

• Influence of the labeling group on ionization and fragmentation of carbohydrates in mass spectrometry.

  Journal of the American Society for Mass Spectrometry 20050501

• A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model.

  Critical care medicine 20050501

• Bacterial translocation in hemorrhagic shock: Are we any wiser?

  Critical care medicine 20050501

• Bacterial translocation and intestinal neutrophil lipid peroxidation in a hemorrhagic shock model--Rat race or rat trap?

  Critical care medicine 20050501

• Electrochemical, quantum-chemical and antioxidant properties of antipyrine and its derivatives.

  Journal of pharmaceutical and biomedical analysis 20050429

• Role of conformation and electronic structure in the chemistry of ground and excited state o-pyrazolylphenylnitrenes.

  Journal of the American Chemical Society 20050420

• Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus.

  European journal of pharmacology 20050411

• ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats.

  Acta pharmacologica Sinica 20050401

• Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.

  Current drug targets. CNS and neurological disorders 20050401

• Novel pyrazole derivatives as potential promising anti-inflammatory antimicrobial agents.

  Archiv der Pharmazie 20050401

• Maternal treatment with MCI-186 does not improve delayed deterioration of cellular bioenergetic state and mitochondrial activity following transient intrauterine ischemia in the fetal rat brain.

  Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20050401

• Synthesis and antiamoebic activities of 1-N-substituted cyclised pyrazoline analogues of thiosemicarbazones.

  Bioorganic & medicinal chemistry 20050315

• Endotoxin from various gram-negative bacteria has differential effects on function of hepatic cytochrome P450 and drug transporters.

  European journal of pharmacology 20050307

• Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches.

  Neurobiology of disease 20050301

• Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase.

  Atherosclerosis 20050301

• Effects of edaravone on human neutrophil function.

  Acta anaesthesiologica Scandinavica 20050301

• A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats.

  The Journal of pharmacology and experimental therapeutics 20050201

• Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat.

  Free radical biology & medicine 20050201

• Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives.

  Bioorganic & medicinal chemistry letters 20050201

• The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia.

  Neuropharmacology 20050201

• Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats.

  Acta anaesthesiologica Scandinavica 20050201

• [Treatment of cerebral infarction patients with IGT].

  Nihon rinsho. Japanese journal of clinical medicine 20050201

• Exploring the role of different drug transport routes in permeability screening.

  Journal of medicinal chemistry 20050127

• Enhancement of topical delivery of drugs via direct penetration by reducing blood flow rate in skin.

  International journal of pharmaceutics 20050120

• Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.

  European journal of pharmacology 20050110

• Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.

  Pharmacology 20050101

• Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats.

  Journal of hepatology 20050101

• [A case of common carotid artery dissection showing remission in short-term].

  No shinkei geka. Neurological surgery 20050101

• MCI-186 inhibits tumor growth through suppression of EGFR phosphorylation and cell cycle arrest.

  Anticancer research 20050101

• Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity.

  Arthritis research & therapy 20050101

• Drug-induced anaphylaxis : case/non-case study based on an italian pharmacovigilance database.

  Drug safety 20050101

• Synthesis and evaluation of N-(5-methyl-3-oxo-1,2- diphenyl-2,3-dihydro-1H-pyrazol-4-yl)-N'-phenylureas as cholecystokinin antagonists.

  Arzneimittel-Forschung 20050101

• Effects of a free radical scavenger, MCI-186, on ischemia-reperfusion injury during extended liver resection in dogs.

  Hepato-gastroenterology 20050101

• [Markers of impact and effects of dioxines in firemen who participated in fire extinguishing at 'Irkutskcabel' plant].

  Meditsina truda i promyshlennaia ekologiia 20050101

• Computational study on use of single-point analysis method for quantitating local cerebral blood flow in mice.

  Advances in experimental medicine and biology 20050101

• Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia.

  Brain research 20041217

• Membrane permeability and antipyrine absorption in a rat model of ischemic colitis.

  International journal of pharmaceutics 20041122

• [Clinical guidelines for stroke].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20041110

• Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution.

  The Journal of pharmacology and experimental therapeutics 20041101

• Simultaneous determination of ropivacaine and antipyrine by high performance liquid chromatography and its application to the in vitro transplacental study.

  Biomedical chromatography : BMC 20041101

• Pretreatment with the free radical scavenger edaravone prevents cerebral hyperperfusion after carotid endarterectomy.

  Neurosurgery 20041101

• Lipopolysaccharide-induced expression of multiple alternatively spliced MEFV transcripts in human synovial fibroblasts: a prominent splice isoform lacks the C-terminal domain that is highly mutated in familial Mediterranean fever.

  Arthritis and rheumatism 20041101

• Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers.

  Environmental health perspectives 20041101

• EPR imaging to estimate the in vivo intracerebral reducing ability of mature rats after neonatal hypoxic-ischemic brain injury.

  Magnetic resonance imaging 20041101

• Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers.

  The American journal of cardiology 20041015

• Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction.

  The Journal of pharmacology and experimental therapeutics 20041001

• Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling.

  Drug metabolism and disposition: the biological fate of chemicals 20041001

• Pharmaceuticals in the river Elbe and its tributaries.

  Chemosphere 20041001

• Efficacy of phenazone in the treatment of acute migraine attacks: a double-blind, placebo-controlled, randomized study.

  Cephalalgia : an international journal of headache 20041001

• Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041001

• Detection and identification of phenazone-type drugs and their microbial metabolites in ground and drinking water applying solid-phase extraction and gas chromatography with mass spectrometric detection.

  Journal of chromatography. A 20041001

• Safety of the new selective cyclooxygenase type 2 inhibitors rofecoxib and celecoxib in patients with anaphylactoid reactions to nonsteroidal anti-inflammatory drugs.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20041001

• Study of hepatic function matching between Banna minipig inbred and humans.

  Transplantation proceedings 20041001

• Zirconium-catalyzed enantioselective [3+2] cycloaddition of hydrazones to olefins leading to optically active pyrazolidine, pyrazoline, and 1,3-diamine derivatives.

  Journal of the American Chemical Society 20040915

• Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11.

  European journal of pharmacology 20040913

• Relationship between flow-metabolism uncoupling and evolving axonal injury after experimental traumatic brain injury.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20040901

• Effect of edaravone on streptomycin-induced vestibulotoxicity in the Guinea pig.

  The Laryngoscope 20040901

• Effects of edaravone on reperfusion injury in patients with acute myocardial infarction.

  The American journal of cardiology 20040815

• Antioxidant effect of MCI-186, a new Free-Radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model.

  The Journal of surgical research 20040801

• MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia.

  The Annals of thoracic surgery 20040801

• Evaluating barriers to bioavailability in vivo: validation of a technique for separately assessing gastrointestinal absorption and hepatic extraction.

  Pharmaceutical research 20040801

• [Study on fluorescence spectra of four kinds of pyrazoline dimers].

  Guang pu xue yu guang pu fen xi = Guang pu 20040801

• Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.

  Proceedings of the National Academy of Sciences of the United States of America 20040727

• Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats.

  Brain research. Developmental brain research 20040719

• Development of a model based on body composition to predict drug kinetics-1 evaluation in healthy volunteers.

  Pharmacological research 20040701

• Enhancement effect of p-menthane-3,8-diol on in vitro permeation of antipyrine and indomethacin through Yucatan micropig skin.

  Drug development and industrial pharmacy 20040701

• Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion.

  Journal of the neurological sciences 20040615

• Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors.

  Bioorganic & medicinal chemistry letters 20040607

• Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes.

  British journal of pharmacology 20040601

• N-[(1E)-Amino[3-methyl-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]methylene]-1H-imidazole-1-carboxamide.

  Acta crystallographica. Section C, Crystal structure communications 20040601

• In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone; Radicut), a clinical drug.

  Journal of radiation research 20040601

• Regulation of drug absorption from small intestine by enteric nervous system I: a poorly absorbable drug via passive diffusion.

  Drug metabolism and pharmacokinetics 20040601

• Transplacental passage of vancomycin in the ex vivo human perfusion model.

  Infectious diseases in obstetrics and gynecology 20040601

• Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.

  Kidney international 20040501

• Tetracycline compound placement to prevent dry socket: a postoperative study of 200 impacted mandibular third molars.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20040501

• Developmental effects of propyphenazone in analgesic and antipyretic combination with caffeine or paracetamol.

  Human & experimental toxicology 20040501

• Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia coli O157:H7.

  Biochemical pharmacology 20040415

• Inhibitory effect of free radical scavenger, MCI-186, in the increase of hydroxyl radical induced by iminodipropionitrile in rats.

  Journal of the neurological sciences 20040415

• Wavelet analysis for the multicomponent determination in a binary mixture of caffeine and propyphenazone in tablets.

  Farmaco (Societa chimica italiana : 1989) 20040401

• Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain.

  Neurological research 20040401

• Edaravone inhibits acute renal injury and cyst formation in cisplatin-treated rat kidney.

  Free radical research 20040401

• The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma.

  European journal of pharmacology 20040308

• Evolution of diaschisis in a focal stroke model.

  Stroke 20040301

• Transfer of inflammatory cytokines across the placenta.

  Obstetrics and gynecology 20040301

• [Propyphenazone. Pharmacology and use].

  Medizinische Monatsschrift fur Pharmazeuten 20040301

• [Research and development of the free radical scavenger edaravone as a neuroprotectant].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040301

• Inappropriately low angiotensin II generation: a factor determining reduced kidney function and survival in patients with decompensated cirrhosis.

  Journal of hepatology 20040301

• Regional heterogeneity of cerebral blood flow response to graded pressure-controlled hemorrhage.

  The Journal of trauma 20040301

• Effect of the arginine-containing mu,delta-opiate receptor agonist sedatin on DNA synthesis in the epithelium of the gastric fundus in albino rats.

  Bulletin of experimental biology and medicine 20040301

• Sex-dependent modulation of treatment response.

  Dialogues in clinical neuroscience 20040301

• Impact of amphotericin B on the cytochrome P450 system in HIV-infected patients.

  European journal of medical research 20040227

• The reaction rate of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with hydroxyl radical.

  Chemical & pharmaceutical bulletin 20040201

• The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury.

  The British journal of surgery 20040201

• [Effects of edaravone, minocycline and ONO-1078 on oxygen/glucose deprivation-induced electrophysiological alteration in rat hippocampal slices].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040201

• Extension of cerebral hypoperfusion and ischaemic pathology beyond MCA territory after intraluminal filament occlusion in C57Bl/6J mice.

  Brain research 20040130

• Activation of cerebral cortex during acoustic challenge or acute foot-shock in freely moving, nontethered rats.

  Neuroscience letters 20040102

• Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs.

  The Journal of pharmacology and experimental therapeutics 20040101

• Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats.

  International journal of molecular medicine 20040101

• [Alterations of antiproliferative effects of serum obtained from patients with acute cerebral infarction treated with a radical scavenger, edaravone, with or without amlodipine using an in vitro cultured basilar artery smooth muscle cells].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040101

• Effects of chronic isovolaemic haemodilution on regional cerebral blood flow in conscious rats.

  European journal of anaesthesiology 20040101

• [Effects of glutamine on antioxidants systems and hepatic detoxification in rats: influence of formulation].

  Nutricion hospitalaria 20040101

• Effect of erythrocytes on the hepatic distribution kinetics of antipyrine.

  European journal of drug metabolism and pharmacokinetics 20040101

• Dynamic tests to study liver function.

  European review for medical and pharmacological sciences 20040101

• High-performance liquid chromatography/inductively coupled plasma mass spectrometry and tandem mass spectrometry for the detection of carbon-containing compounds.

  Rapid communications in mass spectrometry : RCM 20040101

• A new free radical scavenger, edaravone, ameliorates oxidative liver damage due to ischemia-reperfusion in vitro and in vivo.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20040101

• [Determination of nonmetabolized antipyrine in human urine].

  Eksperimental'naia i klinicheskaia farmakologiia 20040101

• The perfused everted intestinal segment of rat. 1st communication: absorption kinetics of markers of different permeation mechanisms.

  Arzneimittel-Forschung 20040101

• Protective effects of a free radical scavenger, MCI-186, on high-glucose-induced dysfunction of human dermal microvascular endothelial cells.

  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20040101

• Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA.

  Korean journal of radiology 20040101

• Dosimetry and risk from low- versus high-LET radiation of Auger events and the role of nuclide carriers.

  International journal of radiation biology 20040101

• Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells.

  Biological & pharmaceutical bulletin 20031201

• 2-Amino-6-(1-imidazolylmethyl)-4-(3,5,5-trimethyl-2-pyrazolin-1-yl)-1,3,5-triazine and 2-amino-6-(1-benzimidazolylmethyl)-4-(3,5,5-trimethyl-2-pyrazolin-1-yl)-1,3,5-triazine hemihydrate.

  Acta crystallographica. Section C, Crystal structure communications 20031201

• [An improved quantitative method for evaluation of ischemic injury and neuroprotection in mouse brain slices].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031201

• Ex vivo human placental transfer of the peptides pramlintide and exenatide (synthetic exendin-4).

  Human & experimental toxicology 20031201

• Diclofenac inhibition of sodium currents in rat dorsal root ganglion neurons.

  Brain research 20031128

• Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

  British journal of cancer 20031117

• A theoretical investigation on DPPH radical-scavenging mechanism of edaravone.

  Bioorganic & medicinal chemistry letters 20031103

• Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression.

  American journal of physiology. Heart and circulatory physiology 20031101

• Inhibition of [18F]FP-TZTP binding by loading doses of muscarinic agonists P-TZTP or FP-TZTP in vivo is not due to agonist-induced reduction in cerebral blood flow.

  Synapse (New York, N.Y.) 20031101

• Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.

  Drug metabolism and disposition: the biological fate of chemicals 20031101

• High-speed electrophoretic analysis of 1-phenyl-3-methyl-5-pyrazolone derivatives of monosaccharides on a quartz microchip with whole-channel UV detection.

  Electrophoresis 20031101

• MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits.

  The Journal of thoracic and cardiovascular surgery 20031101

• Optimization of the RP-HPLC method for multicomponent analgetic drug determination.

  Bollettino chimico farmaceutico 20031101

• [Advances in the diagnosis and treatment of cerebral ischemia during the acute phase].

  Rinsho shinkeigaku = Clinical neurology 20031101

• [Gene therapy and neuroprotection for cerebral infarction].

  Rinsho shinkeigaku = Clinical neurology 20031101

• Free radical scavenger protects against inner hair cell loss after cochlear ischemia.

  Neuroreport 20031006

• Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin.

  The Journal of pharmacology and experimental therapeutics 20031001

• Convergent synthesis and antibacterial activity of pyrazole and pyrazoline derivatives of diazepam.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20031001

• Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes.

  The Journal of biological chemistry 20030919

• Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.

  International journal of pharmaceutics 20030916

• Chemometric evaluation of pharmaceutical properties of antipyrine granules by near-infrared spectroscopy.

  AAPS PharmSciTech 20030901

• The effects of diminazene aceturate on systemic blood pressure in clinically healthy adult dogs.

  Journal of the South African Veterinary Association 20030901

• Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression.

  European journal of pharmacology 20030822

• Lack of interaction of digoxin and P-glycoprotein inhibitors, quinidine and verapamil in human placenta in vitro.

  European journal of obstetrics, gynecology, and reproductive biology 20030815

• Determination of 1-phenyl-3-methyl-5-pyrazolone-labeled carbohydrates by liquid chromatography and micellar electrokinetic chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030805

• High-throughput optimization by statistical designs: example with rat liver slices cryopreservation.

  Analytical biochemistry 20030801

• Functional brain mapping in freely moving rats during treadmill walking.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030801

• 4,5-Dihydro-3-methyl-5-(4-methylphenyl)-1H-pyrazole-1-carboxamide.

  Acta crystallographica. Section C, Crystal structure communications 20030801

• A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury.

  Free radical research 20030801

• The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats.

  International journal of molecular medicine 20030701

• The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats.

  International journal of molecular medicine 20030701

• Clinical usefulness of edaravone for acute liver injury.

  Journal of gastroenterology and hepatology 20030701

• [The clinical effect of combination therapy with edaravone and sodium ozagrel for acute cerebral infarction].

  No to shinkei = Brain and nerve 20030701

• Photolysis of chiral 1-pyrazolines to cyclopropanes: mechanism and stereospecificity.

  The Journal of organic chemistry 20030613

• Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5-one, a free radical scavenger, on acute toxicity of paraquat in mice.

  Toxicology letters 20030605

• Investigation of the release behavior of a covered-rod-type formulation using silicone.

  Journal of controlled release : official journal of the Controlled Release Society 20030605

• Comparison of skin permeation enhancement by 3-l-menthoxypropane-1,2-diol and l-menthol: the permeation of indomethacin and antipyrine through Yucatan micropig skin and changes in infrared spectra and X-ray diffraction patterns of stratum corneum.

  International journal of pharmaceutics 20030604

• Size-tunable emission from 1,3-diphenyl-5-(2-anthryl)-2-pyrazoline nanoparticles.

  Journal of the American Chemical Society 20030604

• A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo.

  The Journal of pharmacology and experimental therapeutics 20030601

• Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.

  Intensive care medicine 20030601

• Efficacy of edaravone, a free radical scavenger, on left ventricular function and structure in diabetes mellitus.

  Journal of cardiovascular pharmacology 20030601

• Changes in antipyrine clearance and platelet count, but not conventional liver tests, correlate with fibrotic change in chronic hepatitis C: value for predicting fibrotic progression.

  The American journal of gastroenterology 20030601

• Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030525

• Synthesis and antimycotic activity of N-azolyl-2,4-dihydroxythiobenzamides.

  Bioorganic & medicinal chemistry 20030515

• Effect of ursodeoxycholic acid on the impairment induced by maternal cholestasis in the rat placenta-maternal liver tandem excretory pathway.

  The Journal of pharmacology and experimental therapeutics 20030501

• Naturopathic treatment for ear pain in children.

  Pediatrics 20030501

• Excretion of foetal bilirubin by the rat placenta-maternal liver tandem.

  Placenta 20030501

• Solid-phase synthesis of pyrazolines and isoxazolines with sodium benzenesulfinate as a traceless linker.

  Organic letters 20030403

• Tuning the photoinduced electron-transfer thermodynamics in 1,3,5-triaryl-2-pyrazoline fluorophores: X-ray structures, photophysical characterization, computational analysis, and in vivo evaluation.

  Journal of the American Chemical Society 20030402

• Determination of polar pharmaceuticals in sewage water of Greece by gas chromatography-mass spectrometry.

  Chemosphere 20030401

• How reversible is hepatic functional impairment in autoimmune hepatitis?

  Journal of gastroenterology and hepatology 20030401

• IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone.

  The Journal of allergy and clinical immunology 20030401

• Inmunoferon, an immunomodulator of natural origin, does not affect the rat liver cytochrome P-450 and phase II conjugation enzymes.

  Methods and findings in experimental and clinical pharmacology 20030401

• Proteolytic enzyme conjugated to SC-glucan as an enzymatic transdermal drug penetration enhancer.

  Die Pharmazie 20030401

• Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver.

  European journal of pharmacology 20030328

• Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig.

  European journal of pharmacology 20030307

• Novel transdermal drug penetration enhancer: synthesis and enhancing effect of alkyldisiloxane compounds containing glucopyranosyl group.

  Journal of controlled release : official journal of the Controlled Release Society 20030307

• Placental passage of clarithromycin surpasses other macrolide antibiotics.

  American journal of obstetrics and gynecology 20030301

• Direct comparison of local cerebral blood flow rates measured by MRI arterial spin-tagging and quantitative autoradiography in a rat model of experimental cerebral ischemia.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030201

• Transplacental passage of lamotrigine in a human placental perfusion system in vitro and in maternal and cord blood in vivo.

  European journal of clinical pharmacology 20030201

• N-in-one permeability studies of heterogeneous sets of compounds across Caco-2 cell monolayers.

  Pharmaceutical research 20030201

• [A new species of the genus Phenylobacterium for the degradation of LAS (linear alkylbenzene sulfonate)].

  Wei sheng wu xue bao = Acta microbiologica Sinica 20030201

• Semi-automated hollow-fibre membrane extraction, a novel enrichment technique for the determination of biologically active compounds in water samples.

  Journal of chromatography. A 20030124

• Analysis of carbohydrates as 1-phenyl-3-methyl-5-pyrazolone derivatives by capillary/microchip electrophoresis and capillary electrochromatography.

  Journal of pharmaceutical and biomedical analysis 20030115

• Syntheses, crystal structures, and luminescent properties of lanthanide complexes with tripodal ligands bearing benzimidazole and pyridine groups.

  Inorganic chemistry 20030113

• Cortical spreading depression causes a long-lasting decrease in cerebral blood flow and induces tolerance to permanent focal ischemia in rat brain.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030101

• Cerebral hypoperfusion and delayed hippocampal response after induction of adult kaolin hydrocephalus.

  Stroke 20030101

• Transarterial chemoembolization (TACE) for unresectable hepatocellular carcinoma in cirrhotics: functional hepatic reserve and survival.

  Hepato-gastroenterology 20030101

• Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters.

  Cerebrovascular diseases (Basel, Switzerland) 20030101

• Influence of nifedipine, nitrendipine and verapamil at low concentration on antipyrine metabolism examined by extracorporeal rat liver perfusion.

  Polish journal of pharmacology 20030101

• Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone).

  Redox report : communications in free radical research 20030101

• Synthesis of the metabolites of a free radical scavenger edaravone (MCI-186, Radicut).

  Redox report : communications in free radical research 20030101

• [Current aspects of the treatment of migraine].

  Likars'ka sprava 20030101

• The bidirectional transfer and fetal vascular pressure changes due to the presence of 125I-labeled inhibin A in the ex-vivo human placental model.

  Infectious diseases in obstetrics and gynecology 20030101

• Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger.

  Arzneimittel-Forschung 20030101

• Effects of edaravone on experimental brain injury in view of free radical reaction.

  Acta neurochirurgica. Supplement 20030101

• Changes in blood flow and function of the liver after right portal vein embolization.

  Archives of surgery (Chicago, Ill. : 1960) 20021201

• Contractile responses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI-186, a new hydroxyl radical scavenger.

  Acta neurochirurgica 20021201

• Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat.

  Transplantation 20021127

• Determination of diminazene aceturate in pharmaceutical formulations by HPLC and identification of related substances by LC/MS.

  Journal of pharmaceutical and biomedical analysis 20021107

• Biological and metabolic study of naproxen-propyphenazone mutual prodrug.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20021101

• Identification and significance of phenazone drugs and their metabolites in ground- and drinking water.

  Chemosphere 20021101

• COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.

  Proceedings of the National Academy of Sciences of the United States of America 20021015

• Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys.

  Drug metabolism and disposition: the biological fate of chemicals 20021001

• An implantable bolus infusion pump for use in freely moving, nontethered rats.

  American journal of physiology. Heart and circulatory physiology 20021001

• Early effects of acid-base management during hypothermia on cerebral infarct volume, edema, and cerebral blood flow in acute focal cerebral ischemia in rats.

  Anesthesiology 20021001

• Dynamic variations of local cerebral blood flow in maximal electroshock seizures in the rat.

  Epilepsia 20021001

• Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20021001

• Myocardial protection of MCI-186 in rabbit ischemia-reperfusion.

  Life sciences 20020927

• Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats.

  European journal of pharmacology 20020913

• Direct analysis of nine pharmaceuticals in culture media by use of cartridge separation with electrospray mass spectrometric detection.

  Analytical and bioanalytical chemistry 20020901

• Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta.

  BJOG : an international journal of obstetrics and gynaecology 20020901

• Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats.

  Neuroscience letters 20020823

• Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method.

  Drug metabolism and disposition: the biological fate of chemicals 20020801

• The concordance of early antipyrine and thiopental distribution kinetics.

  The Journal of pharmacology and experimental therapeutics 20020801

• Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells.

  Pharmaceutical research 20020801

• Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil.

  Experimental brain research 20020701

• 4,5-Dihydro-3-methyl-5-(4-methylphenyl)-1H-pyrazole-1-carboxamidinium acetate acetone hemisolvate.

  Acta crystallographica. Section C, Crystal structure communications 20020701

• Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer.

  International journal of pharmaceutics 20020604

• A study of immunoglobulin G glycosylation in monoclonal and polyclonal species by electrospray and matrix-assisted laser desorption/ionization mass spectrometry.

  Analytical biochemistry 20020601

• Sequential morphological and permeability changes in the rete capillaries during hyperglycaemia.

  Microscopy research and technique 20020601

• Absence of placental transfer of pentasaccharide (Fondaparinux, Arixtra) in the dually perfused human cotyledon in vitro.

  Thrombosis and haemostasis 20020501

• [Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20020501

• Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils.

  Neuroscience research 20020501

• Synthesis of syn and anti isomers of trans-cyclopropyl arginine.

  The Journal of organic chemistry 20020405

• Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI.

  NMR in biomedicine 20020401

• The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020401

• Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans.

  Clinical pharmacology and therapeutics 20020401

• The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans.

  The Journal of pharmacy and pharmacology 20020401

• Enzyme and plasma protein induction by multiple oral administrations of phenobarbital at a therapeutic dosage regimen in dogs.

  Journal of veterinary pharmacology and therapeutics 20020401

• Migraine, Midrin, and Imitrex.

  Headache 20020401

• Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men.

  Clinical pharmacology and therapeutics 20020301

• Influence of albumin supplementation on tacrolimus and cyclosporine therapy early after liver transplantation.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20020301

• Diabetes and elimination of antipyrine in man: an analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement.

  Pharmacology & toxicology 20020301

• Albendazole metabolism in patients with neurocysticercosis: antipyrine as a multifunctional marker drug of cytochrome P450.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20020201

• Exercise-induced oxidative stress in older adults as a function of habitual activity level.

  Journal of the American Geriatrics Society 20020201

• Rational determination of transfer free energies of small drugs across the water-oil interface.

  Journal of medicinal chemistry 20020103

• Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry.

  Clinical chemistry 20020101

• Transplacental transfer and metabolism of buprenorphine.

  The Journal of pharmacology and experimental therapeutics 20020101

• Imaging of ischemic but viable myocardium using a new 18F-labeled 2-nitroimidazole analog, 18F-FRP170.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020101

• Auto-protective redox buffering systems in stimulated macrophages.

  BMC immunology 20020101

• Next generation of everyday analgesics.

  American journal of therapeutics 20020101

• The onset of action and the analgesic efficacy of Saridon (a propyphenazone/paracetamol/ caffeine combination) in comparison with paracetamol, ibuprofen, aspirin and placebo (pooled statistical analysis).

  Current medical research and opinion 20020101

• Probucol and liver efficiency during chemically-induced hepatocarcinogenesis.

  Anticancer research 20020101

• A new method for measuring oxidative stress in claudicants during strenuous exercise using free radical derivatives of antipyrine as indicators: a pilot study.

  Annals of clinical and laboratory science 20020101

• [Absorption function of the large intestine in patients with nonspecific ulcerative colitis].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20020101

• Effects of prenatal exposure to combination of acetaminophen, isopropylantipyrine and caffeine on intrauterine development in rats.

  Human & experimental toxicology 20020101

• Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration.

  Cells, tissues, organs 20020101

• Automated structural assignment of derivatized complex N-linked oligosaccharides from tandem mass spectra.

  Rapid communications in mass spectrometry : RCM 20020101

• Edarabone scavenges nitric oxide.

  Redox report : communications in free radical research 20020101

• [Experience of biologically active supplements to food containing indoles and isothiocyanates in patients with chronic viral hepatitis].

  Voprosy pitaniia 20020101

• Drug-induced hepatitis with hepatic granuloma due to saridon.

  Journal of gastroenterology 20020101

• Comparison of MEGX (monoethylglycinexylidide) and antipyrine tests in patients with liver cirrhosis.

  European journal of drug metabolism and pharmacokinetics 20020101

• An examination of whether human placental perfusion allows accurate prediction of placental drug transport: studies with diazepam.

  Journal of pharmacological and toxicological methods 20020101

• Derivative ratio spectra-zero crossing spectrophotometry and LC method applied to the quantitative determination of paracetamol, propyphenazone and caffeine in ternary mixtures.

  Journal of pharmaceutical and biomedical analysis 20011201

• Exercise-induced oxidative stress in older adults as measured by antipyrine oxidation.

  Metabolism: clinical and experimental 20011201

• Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter.

  Biological & pharmaceutical bulletin 20011201

• Determination of ototoxicity of common otic drops using isolated cochlear outer hair cells.

  The Laryngoscope 20011201

• A female with asymptomatic primary biliary cirrhosis associated with pernicious anemia.

  Journal of gastroenterology and hepatology 20011201

• [Neuroprotective therapy for the treatment of acute ischemic stroke].

  Rinsho shinkeigaku = Clinical neurology 20011201

• [Determination of naoning pian by multi-wavelength linear regression method].

  Guang pu xue yu guang pu fen xi = Guang pu 20011201

• Polymeric transdermal drug penetration enhancer. The enhancing effect of oligodimethylsiloxane containing a glucopyranosyl end group.

  Journal of controlled release : official journal of the Controlled Release Society 20011109

• Effects of recombinant tissue plasminogen activator after intraluminal thread occlusion in mice: role of hemodynamic alterations.

  Stroke 20011101

• Placental transfer of SR49059 in the human dually perfused cotyledon in vitro.

  Placenta 20011101

• Antioxidant supplementation and exercise-induced oxidative stress in the 60-year-old as measured by antipyrine hydroxylates.

  The British journal of nutrition 20011101

• Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver.

  Human & experimental toxicology 20011101

• Theoretical considerations on the in vivo intestinal permeability determination by means of the single pass and recirculating techniques.

  International journal of pharmaceutics 20011023

• Regioselective synthesis of polysubstituted pyrazoles and isoxazoles.

  The Journal of organic chemistry 20011005

• Phosphorylation of cyclic adenosine monophosphate response element binding protein in oligodendrocytes in the corpus callosum after focal cerebral ischemia in the rat.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011001

• Exercise training and oxidative stress in the elderly as measured by antipyrine hydroxylation products.

  Free radical research 20011001

• Ten-year combination treatment with colchicine and ursodeoxycholic acid for primary biliary cirrhosis: a double-blind, placebo-controlled trial on symptomatic patients.

  Alimentary pharmacology & therapeutics 20010901

• Cognitive toxicity of drugs used in the elderly.

  Dialogues in clinical neuroscience 20010901

• Schedule of controlled substances: placement of dichloralphenazone into Schedule IV. Final rule.

  Federal register 20010816

• An autoradiographic study of regional blood flow distribution in the rat kidney during ureteric obstruction--the role of vasoactive compounds.

  BJU international 20010801

• Lack of hypercapnic increase in cerebral blood flow at high blood viscosity in conscious blood-exchanged rats.

  Anesthesiology 20010801

• Impairment of metabolic function in chronic hepatitis C is related to factors associated with resistance to therapy.

  The American journal of gastroenterology 20010801

• Dissociation of brain edema induced by cold injury in rat model: MR imaging and perfusion studies with 14C-iodo-antipyrine.

  Annals of nuclear medicine 20010801

• Simultaneous measurement of cerebral blood flow and mRNA signals: pixel-based inter-modality correlational analysis.

  Journal of neuroscience methods 20010730

• ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.

  Journal of medicinal chemistry 20010719

• The effects of uterine and umbilical blood flows on the transfer of propofol across the human placenta during in vitro perfusion.

  Anesthesia and analgesia 20010701

• Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media.

  Archives of pediatrics & adolescent medicine 20010701

• Uncoupling of cerebral blood flow and metabolism after cerebral contusion in the rat.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010701

• Disease recurrence after living liver transplantation for primary biliary cirrhosis: a clinical and histological follow-up study.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20010701

• Experimental and computational screening models for the prediction of intestinal drug absorption.

  Journal of medicinal chemistry 20010607

• Direct nuclear magnetic resonance spectroscopic analysis of (13)C-labeled antipyrine metabolites in human urine.

  Drug metabolism and disposition: the biological fate of chemicals 20010601

• Oxygen delivery at high blood viscosity and decreased arterial oxygen content to brains of conscious rats.

  American journal of physiology. Heart and circulatory physiology 20010601

• Metabolic functions of the liver during chemotherapy in children with acute lymphoblastic leukemia.

  International journal of clinical pharmacology and therapeutics 20010601

• Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines.

  European journal of medicinal chemistry 20010601

• In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery.

  Journal of controlled release : official journal of the Controlled Release Society 20010518

• Structure-hepatic disposition relationships for cationic drugs in isolated perfused rat livers: transmembrane exchange and cytoplasmic binding process.

  The Journal of pharmacology and experimental therapeutics 20010501

• Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter.

  Biological & pharmaceutical bulletin 20010501

• Investigation of different combinations of derivatization, separation methods and electrospray ionization mass spectrometry for standard oligosaccharides and glycans from ovalbumin.

  Journal of mass spectrometry : JMS 20010501

• Metabolic capacity and interindividual variation in toxicokinetics of styrene in volunteers.

  Human & experimental toxicology 20010501

• Antioxidants reduce oxidative stress in claudicants.

  The Journal of surgical research 20010401

• Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine.

  Headache 20010401

• Capillary electrophoretic analysis of carbohydrates derivatized by in-capillary condensation with 1-phenyl-3-methyl-5-pyrazolone.

  Journal of chromatography. A 20010316

• Analysis of sialo-N-glycans in glycoproteins as 1-phenyl-3-methyl-5-pyrazolone derivatives by capillary electrophoresis.

  Journal of chromatography. A 20010302

• Drug-induced hemodynamic perturbations alter the disposition of markers of blood volume, extracellular fluid, and total body water.

  The Journal of pharmacology and experimental therapeutics 20010301

• Quantitative analysis of rat inner ear blood flow using the iodo[(14)C]antipyrine technique.

  Hearing research 20010301

• Comparison of cell inactivation by Auger electrons using the two reagents 4-[123I]iodoantipyrine and [123I]NaI.

  Radiation and environmental biophysics 20010301

• Urine antipyrine metabolites in rats with different resistance to hypoxia subjected to cold stress.

  Bulletin of experimental biology and medicine 20010301

• Intravenous pharmacokinetics of penicillin G and antipyrine in ostriches (Struthio camelus) and emus (Dromaius novaehollandiae).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010301

• Transplacental transfer of amitriptyline and nortriptyline in isolated perfused human placenta.

  Psychopharmacology 20010201

• Antipyrine clearance and metabolite formation in primary biliary cirrhosis.

  Digestive diseases and sciences 20010201

• The discovery of indoxacarb: oxadiazines as a new class of pyrazoline-type insecticides.

  Pest management science 20010201

• [Simultaneous determination of three components in antongding injection by Kalman filtering method].

  Guang pu xue yu guang pu fen xi = Guang pu 20010201

• Experimental stroke in the female diabetic, db/db, mouse.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010101

• Enhancement of jejunal absorption of conjugated bile acid by neurotensin in rats.

  Gastroenterology 20010101

• Pesticidal properties of parthenin (from Parthenium hysterophorus) and related compounds.

  Pest management science 20010101

• Synthesis and antimicrobial activity of novel pyrazole, pyrazoline, pyrazolinone and pyrazolidinedione derivatives of benzimidazole.

  Bollettino chimico farmaceutico 20010101

• Clinical pharmacokinetics of quetiapine: an atypical antipsychotic.

  Clinical pharmacokinetics 20010101

• [The liver monooxygenase system activity in the long-term compression syndrome and treatment with benzonal in prepubertal rats and rabbits].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• [Effect of hypoxic stress on xenobiotic metabolism and activities of various isoforms of cytochrome P-450].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity.

  European journal of medicinal chemistry 20010101

• Pharmacokinetic and pharmacodynamic aspects of the ideal COX-2 inhibitor: a pharmacologist's perspective.

  Clinical and experimental rheumatology 20010101

• [Changes in the immune status parameters and their correction in various forms of tick-borne encephalitis].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20010101

• Effect of phenobarbital and spironolactone treatment on the oxidative metabolism of antipyrine by rat liver microsomes.

  Polish journal of pharmacology 20010101

• Induction of hepatic and presystemic metabolism of antipyrine in the mice: rifampicin versus rifabutin.

  European journal of drug metabolism and pharmacokinetics 20010101

• [Optimal conditions for extraction of 'caffetin' and 'saridon' tablet components from aqueous solutions].

  Sudebno-meditsinskaia ekspertiza 20010101

• [Insidious drug eruption].

  Duodecim; laaketieteellinen aikakauskirja 20010101

• The role of nitro-reduction and nitric oxide in the toxicity of chloramphenicol.

  Human & experimental toxicology 19990201

• Effect of zidovudine therapy in patients with HIV infection on endogenous interferon plasma levels and the hepatic cytochrome P450 enzyme system.

  Chemotherapy 19980101

• Autoimmune haemolytic anaemia induced by propyphenazone.

  Vox sanguinis 19980101

• Synthesis of some N,N-disubstituted carbamodithioic acid esters tested for antifungal activity.

  Farmaco (Societa chimica italiana : 1989) 19950501

• Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease.

  American journal of veterinary research 19940201

• Liver enzyme induction and serum lipid levels after replacement of carbamazepine with oxcarbazepine.

  Epilepsia 19940101

• Antipyrine congeners as antidepressant agents.

  Arzneimittel-Forschung 19931001

• Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients.

  British journal of clinical pharmacology 19930901

• Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis.

  Scandinavian journal of gastroenterology 19930801

• Neurotoxicity after intracarotid 1,3-bis(2-chloroethyl)-1-nitrosourea administration in the rat: hemodynamic changes studied by double-tracer autoradiography.

  Neurosurgery 19910701

• A fatality after antipyrine administration.

  Clinical pharmacology and therapeutics 19910601

• Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats.

  Japanese journal of cancer research : Gann 19910201

• CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment.

  Journal of hepatology 19910101

• [Benign intracranial hypertension caused by sulfenazone].

  La Pediatria medica e chirurgica : Medical and surgical pediatrics 19890101

• Microsomal enzyme induction by permethrin in rats.

  Veterinary and human toxicology 19880801

• The influence of antipyrene on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced urinary tract carcinogenesis.

  Carcinogenesis 19880501

• Diagnosis of antibody-mediated drug allergy. Pyrazolinone and pyrazolidinedione cross-reactivity relationships.

  Allergy 19871101

• Risks of agranulocytosis and aplastic anemia. A first report of their relation to drug use with special reference to analgesics. The International Agranulocytosis and Aplastic Anemia Study.

  JAMA 19861003

• Morphological changes in the liver due to phenazone and its derivatives.

  Agents and actions. Supplements 19860101

• [Toxic hemolytic anemia in the newborn infant following ingestion of a phenazone derivative (Cibalgin) via breast milk].

  Zeitschrift fur Geburtshilfe und Perinatologie 19850101

• A new reproducible experimental model of analgesic nephropathy.

  The Journal of pathology 19830101

• Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.

  Acta pathologica et microbiologica Scandinavica. Section A, Pathology 19810501

• Analgesic nephropathy induced by common proprietary mixtures.

  The Medical journal of Australia 19800517

• The radiological diagnosis of analgesic nephropathy.

  Clinical radiology 19750701

• Recurrent acute renal failure induced by phenazone hypersensitivity.

  Lancet (London, England) 19731229

• Toxic liver injuries.

  Acta pathologica japonica 19730801

• The origins of analgesic nephropathy.

  The British journal of psychiatry : the journal of mental science 19730701

• Iatrogenic encephalopathy.

  Postgraduate medical journal 19700501

• Short-term study of the effect of phenacetin, phenazone and amidopyrine on the rat kidney.

  British journal of pharmacology and chemotherapy 19680101