600-18-0 | 2-Oxobutanoic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$12.00	$8.00
1g	98%	in stock	$22.00	$16.00
5g	98%	in stock	$80.00	$56.00
25g	98%	in stock	$320.00	$224.00
100g	98%	in stock	$1,016.00	$712.00

Description

• Catalog Number: AB62445
• Chemical Name: 2-Oxobutanoic acid
• CAS Number: 600-18-0
• Molecular Formula: C4H6O3
• Molecular Weight: 102.0886
• MDL Number: MFCD00004164
• SMILES: CCC(=O)C(=O)O
• NSC Number: 60533

Computed Properties

• Complexity: 95.1
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 0.1

Literature

• Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents.

  Nature chemistry 20141001

• Exploration of the active site of Escherichia coli cystathionine γ-synthase.

  Protein science : a publication of the Protein Society 20121101

• Crystal structure of reaction intermediates in pyruvate class II aldolase: substrate cleavage, enolate stabilization, and substrate specificity.

  The Journal of biological chemistry 20121019

• Microbial Community-Level Physiological Profiles (CLPP) and herbicide mineralization potential in groundwater affected by agricultural land use.

  Journal of contaminant hydrology 20121001

• Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death.

  The Journal of biological chemistry 20120914

• Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death.

  Oncogene 20120816

• Expression, purification, crystallization and preliminary X-ray analysis of 4-hydroxy-3-methyl-2-keto-pentanoate aldolase (asHPAL) from Arthrobacter simplex strain AKU 626.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20120801

• Isolation of Rhizobacteria from Jatropha curcas and characterization of produced ACC deaminase.

  Journal of basic microbiology 20120601

• Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I.

  The FEBS journal 20120601

• Development of a continuous assay and steady-state characterization of Escherichia coli threonine synthase.

  Analytical biochemistry 20120401

• Efficient bioconversion of l-threonine to 2-oxobutyrate using whole cells of Pseudomonas stutzeri SDM.

  Bioresource technology 20120401

• System-level insights into yeast metabolism by thermodynamic analysis of elementary flux modes.

  PLoS computational biology 20120301

• Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.

  Autophagy 20120201

• Biosynthesis of polyhydroxyalkanoates containing 2-hydroxybutyrate from unrelated carbon source by metabolically engineered Escherichia coli.

  Applied microbiology and biotechnology 20120101

• Combined inactivation of the Clostridium cellulolyticum lactate and malate dehydrogenase genes substantially increases ethanol yield from cellulose and switchgrass fermentations.

  Biotechnology for biofuels 20120101

• Autophagy and mechanisms of effective immunity.

  Frontiers in immunology 20120101

• Variable carbon catabolism among Salmonella enterica serovar Typhi isolates.

  PloS one 20120101

• Recent progress in synthetic biology for microbial production of C3-C10 alcohols.

  Frontiers in microbiology 20120101

• Mechanistic studies on the enzymatic processing of fluorinated methionine analogues by Trichomonas vaginalis methionine γ-lyase.

  The Biochemical journal 20110915

• Multimodal dynamic response of the Buchnera aphidicola pLeu plasmid to variations in leucine demand of its host, the pea aphid Acyrthosiphon pisum.

  Molecular microbiology 20110901

• Renewable energy from Cyanobacteria: energy production optimization by metabolic pathway engineering.

  Applied microbiology and biotechnology 20110801

• Asymmetric formal [3+2] cycloaddition reaction of isocyanoesters to 2-oxobutenoate esters by a multifunctional chiral silver catalyst.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110704

• Night-time atmospheric chemistry of methacrylates.

  Environmental science and pollution research international 20110701

• The decoupling between genetic structure and metabolic phenotypes in Escherichia coli leads to continuous phenotypic diversity.

  Journal of evolutionary biology 20110701

• Chemopreventive mechanisms of α-keto acid metabolites of naturally occurring organoselenium compounds.

  Amino acids 20110601

• Exploring methionine γ-lyase structure-function relationship via microspectrophotometry and X-ray crystallography.

  Biochimica et biophysica acta 20110601

• Effects of gamma-ray-induced free radicals on the metal content and amino acid composition of human metallothionein-1.

  Journal of biosciences 20110601

• The hepatocarcinogenic effect of methionine and choline deficient diets: an adaptation to the Warburg effect?

  Alcoholism, clinical and experimental research 20110501

• Significant catalytic roles for Glu47 and Gln 110 in all four of the C-C bond-making and -breaking steps of the reactions of acetohydroxyacid synthase II.

  Biochemistry 20110419

• Kinetic resolution of 2-hydroxybutanoate racemic mixtures by NAD-independent L-lactate dehydrogenase.

  Bioresource technology 20110401

• ACC deaminase activity in avirulent Agrobacterium tumefaciens D3.

  Canadian journal of microbiology 20110401

• Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.

  Biochemistry 20110322

• Computational screening of novel thiamine-catalyzed decarboxylation reactions of 2-keto acids.

  Bioprocess and biosystems engineering 20110301

• Cloning and characterisation of a cystathionine β/γ-lyase from two Oenococcus oeni oenological strains.

  Applied microbiology and biotechnology 20110201

• Product-assisted catalysis as the basis of the reaction specificity of threonine synthase.

  The Journal of biological chemistry 20110128

• From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis.

  The Plant cell 20110101

• De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growth.

  PloS one 20110101

• Molecular breeding of advanced microorganisms for biofuel production.

  Journal of biomedicine & biotechnology 20110101

• Assay of the multiple energy-producing pathways of mammalian cells.

  PloS one 20110101

• Glycated albumin suppresses glucose-induced insulin secretion by impairing glucose metabolism in rat pancreatic β-cells.

  Nutrition & metabolism 20110101

• Deep sequencing reveals the complex and coordinated transcriptional regulation of genes related to grain quality in rice cultivars.

  BMC genomics 20110101

• The existence of an insulin-stimulated glucose and non-essential but not essential amino acid substrate interaction in diabetic pigs.

  BMC biochemistry 20110101

• Carbon metabolic pathways in phototrophic bacteria and their broader evolutionary implications.

  Frontiers in microbiology 20110101

• Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread.

  Nutrition journal 20110101

• Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population.

  Journal of cardiovascular disease research 20110101

• Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control.

  Malaria journal 20110101

• The evolution of metabolic networks of E. coli.

  BMC systems biology 20110101

• Dehydratase mediated 1-propanol production in metabolically engineered Escherichia coli.

  Microbial cell factories 20110101

• Dietary deficiency of essential amino acids rapidly induces cessation of the rat estrous cycle.

  PloS one 20110101

• When Cells Suffocate: Autophagy in Cancer and Immune Cells under Low Oxygen.

  International journal of cell biology 20110101

• Three-component assembly and divergent ring-expansion cascades of functionalized 2-iminooxetanes.

  Angewandte Chemie (International ed. in English) 20101122

• Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment.

  Molecular genetics and metabolism 20101001

• Characterization of a dual specificity aryl acid adenylation enzyme with dual function in nikkomycin biosynthesis.

  Biopolymers 20100901

• Cloning and characterization of a plasmid encoded ACC deaminase from an indigenous Pseudomonas fluorescens FY32.

  Current microbiology 20100701

• Engineering Corynebacterium glutamicum for isobutanol production.

  Applied microbiology and biotechnology 20100701

• Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli.

  Biochemistry 20100629

• Identification of a sotolon pathway in dry white wines.

  Journal of agricultural and food chemistry 20100623

• Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling.

  Biochemistry 20100504

• Characterization of two isotypes of l-threonine dehydratase from Entamoeba histolytica.

  Molecular and biochemical parasitology 20100401

• Characterization of ACC deaminase gene in Pseudomonas entomophila strain PS-PJH isolated from the rhizosphere soil.

  Journal of basic microbiology 20100401

• Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin.

  Microbiology (Reading, England) 20100301

• Microbial L-methioninase: production, molecular characterization, and therapeutic applications.

  Applied microbiology and biotechnology 20100301

• Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns.

  The Plant cell 20100301

• Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production.

  Journal of molecular biology 20100226

• Alternative isoleucine synthesis pathway in cyanobacterial species.

  Microbiology (Reading, England) 20100201

• Genome sequence of the pea aphid Acyrthosiphon pisum.

  PLoS biology 20100201

• Pentanol isomer synthesis in engineered microorganisms.

  Applied microbiology and biotechnology 20100101

• Predicting the pathway involved in post-translational modification of elongation factor P in a subset of bacterial species.

  Biology direct 20100101

• The path to next generation biofuels: successes and challenges in the era of synthetic biology.

  Microbial cell factories 20100101

• The complete multipartite genome sequence of Cupriavidus necator JMP134, a versatile pollutant degrader.

  PloS one 20100101

• Prediction of novel synthetic pathways for the production of desired chemicals.

  BMC systems biology 20100101

• alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population.

  PloS one 20100101

• Microbial electrosynthesis: feeding microbes electricity to convert carbon dioxide and water to multicarbon extracellular organic compounds.

  mBio 20100101

• Synthetic biology guides biofuel production.

  Journal of biomedicine & biotechnology 20100101

• Crystal structure of the Formin mDia1 in autoinhibited conformation.

  PloS one 20100101

• Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence.

  BMC genomics 20100101

• Characterization of acetohydroxyacid synthase I from Escherichia coli K-12 and identification of its inhibitors.

  Bioscience, biotechnology, and biochemistry 20100101

• Metabolic response of Geobacter sulfurreducens towards electron donor/acceptor variation.

  Microbial cell factories 20100101

• Biosynthesis of chiral 3-hydroxyvalerate from single propionate-unrelated carbon sources in metabolically engineered E. coli.

  Microbial cell factories 20100101

• Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women.

  PloS one 20100101

• Experimental study of photooxidation products of ethylbenzene.

  Journal of environmental sciences (China) 20100101

• Branched-Chain Amino Acid Metabolism in Arabidopsis thaliana.

  The arabidopsis book 20100101

• The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.

  Nature chemical biology 20091201

• The role of autophagy in tumour development and cancer therapy.

  Expert reviews in molecular medicine 20091201

• Transaminase-catalyzed asymmetric synthesis of L-2-aminobutyric acid from achiral reactants.

  Biotechnology letters 20091001

• Dual effects of aliphatic carboxylic acids on cresolase and catecholase reactions of mushroom tyrosinase.

  Journal of enzyme inhibition and medicinal chemistry 20091001

• Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation.

  Plant molecular biology 20091001

• Engineering the substrate binding site of benzoylformate decarboxylase.

  Biochemistry 20090908

• Arabidopsis methionine gamma-lyase is regulated according to isoleucine biosynthesis needs but plays a subordinate role to threonine deaminase.

  Plant physiology 20090901

• Catalytic asymmetric synthesis of beta-sultams as precursors for taurine derivatives.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20090817

• A high affinity pyruvate decarboxylase is present in cottonwood leaf veins and petioles: a second source of leaf acetaldehyde emission?

  Phytochemistry 20090701

• Abnormal tricarboxylic acid cycle metabolites in isovaleric acidaemia.

  Journal of inherited metabolic disease 20090601

• Modulation of butyrate transport in Caco-2 cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20090401

• Selective backbone labelling of ILV methyl labelled proteins.

  Journal of biomolecular NMR 20090401

• Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase.

  The FEBS journal 20090301

• Coordinations between gene modules control the operation of plant amino acid metabolic networks.

  BMC systems biology 20090101

• Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters.

  Molecular systems biology 20090101

• Characterization of alpha-isopropylmalate synthases containing different copy numbers of tandem repeats in Mycobacterium tuberculosis.

  BMC microbiology 20090101

• Carbohydrate metabolism and carbon fixation in Roseobacter denitrificans OCh114.

  PloS one 20090101

• Non-antibiotic selection systems for soybean somatic embryos: the lysine analog aminoethyl-cysteine as a selection agent.

  BMC biotechnology 20090101

• Potential plant growth promoting traits and bioacidulation of rock phosphate by thiosulfate oxidizing bacteria isolated from crop plants.

  Journal of basic microbiology 20081201

• The interconversion of ACC deaminase and D-cysteine desulfhydrase by directed mutagenesis.

  Planta 20081201

• Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.

  Bioorganic & medicinal chemistry 20081201

• Metabolic engineering of Escherichia coli for 1-butanol and 1-propanol production via the keto-acid pathways.

  Metabolic engineering 20081101

• Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment.

  Journal of biomolecular NMR 20081001

• Genome-scale reconstruction and analysis of the Pseudomonas putida KT2440 metabolic network facilitates applications in biotechnology.

  PLoS computational biology 20081001

• Identification of a methioninase inhibitor, myrsinoic acid B, from Myrsine seguinii Lév., and its inhibitory activities.

  Bioscience, biotechnology, and biochemistry 20080901

• Tetrazolium reduction methods for assessment of substrate oxidation and strain differentiation among mycoplasmas, with particular reference to Mycoplasma bovigenitalium and some members of the Mycoplasma mycoides cluster.

  Journal of applied microbiology 20080801

• The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium.

  Cell death and differentiation 20080801

• Isothermal titration microcalorimetry reveals the cooperative and noncompetitive nature of inhibition of Sinorhizobium meliloti L5-30 dihydrodipicolinate synthase by (S)-lysine.

  Biochemistry 20080729

• Structural, functional and calorimetric investigation of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti l5-30, does not support involvement in rhizopine biosynthesis.

  Chembiochem : a European journal of chemical biology 20080702

• Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function.

  Diabetes 20080701

• Structural insight into substrate binding and catalysis of a novel 2-keto-3-deoxy-D-arabinonate dehydratase illustrates common mechanistic features of the FAH superfamily.

  Journal of molecular biology 20080530

• Fertilizer-dependent efficiency of Pseudomonads for improving growth, yield, and nutrient use efficiency of wheat (Triticum aestivum L.).

  Applied microbiology and biotechnology 20080501

• Methyl jasmonate-elicited herbivore resistance: does MeJA function as a signal without being hydrolyzed to JA?

  Planta 20080401

• Metabolism of halophilic archaea.

  Extremophiles : life under extreme conditions 20080301

• Optimized two-dimensional thin layer chromatography to monitor the intracellular concentration of acetyl phosphate and other small phosphorylated molecules.

  Biological procedures online 20080101

• Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae.

  Genome biology 20080101

• The hidden universal distribution of amino acid biosynthetic networks: a genomic perspective on their origins and evolution.

  Genome biology 20080101

• Native bacterial endophytes promote host growth in a species-specific manner; phytohormone manipulations do not result in common growth responses.

  PloS one 20080101

• Iterative reconstruction of a global metabolic model of Acinetobacter baylyi ADP1 using high-throughput growth phenotype and gene essentiality data.

  BMC systems biology 20080101

• Norvaline is accumulated after a down-shift of oxygen in Escherichia coli W3110.

  Microbial cell factories 20080101

• Deregulation of acetohydroxy-acid synthase: Loss of allosteric inhibition conferred by mutations in the catalytic subunit.

  Folia microbiologica 20080101

• ACC deaminase from plant growth-promoting bacteria affects crown gall development.

  Canadian journal of microbiology 20071201

• Perspective of plant growth promoting rhizobacteria (PGPR) containing ACC deaminase in stress agriculture.

  Journal of industrial microbiology & biotechnology 20071001

• SanM catalyzes the formation of 4-pyridyl-2-oxo-4-hydroxyisovalerate in nikkomycin biosynthesis by interacting with SanN.

  Biochemical and biophysical research communications 20070914

• Selection and properties of alpha-acetolactate decarboxylase-deficient spontaneous mutants of Streptococcus thermophilus.

  Food microbiology 20070901

• Structure and function of enzymes involved in the anaerobic degradation of L-threonine to propionate.

  Journal of biosciences 20070901

• A novel strategy for enzymatic synthesis of 4-hydroxyisoleucine: identification of an enzyme possessing HMKP (4-hydroxy-3-methyl-2-keto-pentanoate) aldolase activity.

  FEMS microbiology letters 20070801

• Perspectives of bacterial ACC deaminase in phytoremediation.

  Trends in biotechnology 20070801

• Synthesis of 4-hydroxyisoleucine by the aldolase-transaminase coupling reaction and basic characterization of the aldolase from Arthrobacter simplex AKU 626.

  Bioscience, biotechnology, and biochemistry 20070701

• Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.

  Biochemistry 20070626

• Biomass in the manufacture of industrial products--the use of proteins and amino acids.

  Applied microbiology and biotechnology 20070601

• Rhythm of the beta-cell oscillator is not governed by a single regulator: multiple systems contribute to oscillatory behavior.

  American journal of physiology. Endocrinology and metabolism 20070501

• Bacillus decisifrondis sp. nov., isolated from soil underlying decaying leaf foliage.

  International journal of systematic and evolutionary microbiology 20070501

• Transcriptional analysis of L-methionine catabolism in Brevibacterium linens ATCC9175.

  Applied microbiology and biotechnology 20070401

• Autophagy gene-dependent clearance of apoptotic cells during embryonic development.

  Cell 20070309

• Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

  Plant & cell physiology 20070201

• The crystal structure of Escherichia coli TdcF, a member of the highly conserved YjgF/YER057c/UK114 family.

  BMC structural biology 20070101

• [Overproduction of noncanonical amino acids by Escherichia coli cells].

  Mikrobiologiia 20070101

• Crystal structures of Salmonella typhimurium biodegradative threonine deaminase and its complex with CMP provide structural insights into ligand-induced oligomerization and enzyme activation.

  The Journal of biological chemistry 20061222

• A threonine synthase homolog from a mammalian genome.

  Biochemical and biophysical research communications 20061201

• Silencing threonine deaminase and JAR4 in Nicotiana attenuata impairs jasmonic acid-isoleucine-mediated defenses against Manduca sexta.

  The Plant cell 20061101

• Development of a convenient new synthetic route to [3]ferrocenophanones.

  Dalton transactions (Cambridge, England : 2003) 20060414

• Hypobaric hypoxia affects endogenous levels of alpha-keto acids in murine heart ventricles.

  Biochemical and biophysical research communications 20060414

• Somatostatin inhibits oxidative respiration in pancreatic beta-cells.

  Endocrinology 20060301

• Crystallization and preliminary X-ray crystallographic analysis of biodegradative threonine deaminase (TdcB) from Salmonella typhimurium.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20060301

• Effect of plant growth promoting rhizobacteria containing ACC-deaminase on maize (Zea mays L.) growth under axenic conditions and on nodulation in mung bean (Vigna radiata L.).

  Letters in applied microbiology 20060201

• Cystathionine gamma-lyase contributes to selenomethionine detoxification and cytosolic glutathione peroxidase biosynthesis in mouse liver.

  Biological trace element research 20060201

• Purifications and characterizations of a ferredoxin and its related 2-oxoacid:ferredoxin oxidoreductase from the hyperthermophilic archaeon, Sulfolobus solfataricus P1.

  Journal of biochemistry and molecular biology 20060131

• Novel ligands for the extracellular solute receptors of two bacterial TRAP transporters.

  Microbiology (Reading, England) 20060101

• Eleven ancestral gene families lost in mammals and vertebrates while otherwise universally conserved in animals.

  BMC evolutionary biology 20060101

• Methionine catabolism in Saccharomyces cerevisiae.

  FEMS yeast research 20060101

• Accelerating the reconstruction of genome-scale metabolic networks.

  BMC bioinformatics 20060101

• Pyruvate protects glucose-deprived Müller cells from nitric oxide-induced oxidative stress by radical scavenging.

  Glia 20051201

• Alterations in neutrophil (PMN) free intracellular alpha-keto acid profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine.

  Amino acids 20051101

• Biocatalytic approaches to hetero-Diels-Alder adducts of carbonyl compounds.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20051007

• Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily.

  Journal of molecular biology 20050930

• Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy.

  Analytical biochemistry 20050701

• The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation.

  Oncogene 20050616

• Gene expression and characterization of two 2-oxoacid:ferredoxin oxidoreductases from Aeropyrum pernix K1.

  FEBS letters 20050425

• Structure of ACC synthase inactivated by the mechanism-based inhibitor L-vinylglycine.

  FEBS letters 20050425

• Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver.

  Protein science : a publication of the Protein Society 20050301

• Bombesin and nutrients independently and additively regulate hormone release from GIP/Ins cells.

  American journal of physiology. Endocrinology and metabolism 20050101

• Bioinformatic mapping of AlkB homology domains in viruses.

  BMC genomics 20050101

• Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene.

  BMC genomics 20050101

• The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana.

  Plant molecular biology 20050101

• Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of propionate kinase (TdcD) from Salmonella typhimurium.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20050101

• Propanol as an end product of threonine fermentation.

  Archives of microbiology 20041201

• Expression and characterization of 1-aminocyclopropane-1-carboxylate deaminase from the rhizobacterium Pseudomonas putida UW4: a key enzyme in bacterial plant growth promotion.

  Biochimica et biophysica acta 20041201

• Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction.

  Biochemistry 20041026

• Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.

  The Journal of endocrinology 20041001

• Transcarboxylase 5S structures: assembly and catalytic mechanism of a multienzyme complex subunit.

  The EMBO journal 20040915

• Structural and enzymatic properties of 1-aminocyclopropane-1-carboxylate deaminase homologue from Pyrococcus horikoshii.

  Journal of molecular biology 20040820

• Role of a conserved arginine in the mechanism of acetohydroxyacid synthase: catalysis of condensation with a specific ketoacid substrate.

  The Journal of biological chemistry 20040604

• Assay method for antitumor L-methionine gamma-lyase: comprehensive kinetic analysis of the complex reaction with L-methionine.

  Analytical biochemistry 20040415

• 4-methylthio 2-oxobutanoate transaminase: a specific target for antiproliferative agents.

  Bulletin du cancer 20040401

• Evaluation of the Escherichia coli threonine deaminase gene as a selectable marker for plant transformation.

  Planta 20040301

• S-methylmethionine is both a substrate and an inactivator of 1-aminocyclopropane-1-carboxylate synthase.

  Archives of biochemistry and biophysics 20040101

• Electrospray ionization mass spectrometry in the structural characterization of some diphenyllead(IV) thiosemicarbazonates.

  Rapid communications in mass spectrometry : RCM 20040101

• Effect of alpha-ketobutyrate on microvascular thickness in the diabetic rat kidney.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20031201

• Conversion of the aminocrotonate intermediate limits the rate of gamma-elimination reaction catalyzed by L-cystathionine gamma-lyase of the yeast Saccharomyces cerevisiae.

  Journal of biochemistry 20031001

• Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.

  Diabetologia 20030901

• Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene.

  Drug metabolism and disposition: the biological fate of chemicals 20030801

• Anaplerotic reactions in tumour proliferation and apoptosis.

  Biochemical pharmacology 20030801

• 3-Hydroxy-4,5-dimethyl-2(5H)-furanone: a key odorant of the typical aroma of oxidative aged Port wine.

  Journal of agricultural and food chemistry 20030716

• The anabolic pyruvate oxidoreductase from Methanococcus maripaludis.

  Archives of microbiology 20030601

• Finding of an isoleucine derivative of a recombinant protein for pharmaceutical use.

  Journal of pharmaceutical and biomedical analysis 20030401

• A sensitive and robust method for obtaining intermolecular NOEs between side chains in large protein complexes.

  Journal of biomolecular NMR 20030301

• Reaction of 1-amino-2-methylenecyclopropane-1-carboxylate with 1-aminocyclopropane-1-carboxylate deaminase: analysis and mechanistic implications.

  Biochemistry 20030225

• Structure and function correlations between the rat liver threonine deaminase and aminotransferases.

  Biochimica et biophysica acta 20030131

• Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family.

  Biochemistry 20030114

• Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids.

  Biochemistry 20030114

• Strategies used by rhizobia to lower plant ethylene levels and increase nodulation.

  Canadian journal of microbiology 20021101

• Amino acid catabolism and generation of volatiles by lactic acid bacteria.

  Journal of dairy science 20021001

• Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides.

  Toxicology letters 20020905

• Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo.

  Journal of cellular physiology 20020901

• Investigations of outbreaks of contagious caprine pleuropneumonia in Eritrea.

  Tropical animal health and production 20020901

• Pyruvate restores contractile function and antioxidant defenses of hydrogen peroxide-challenged myocardium.

  Journal of molecular and cellular cardiology 20020901

• Methyl mercaptan production by periodontal bacteria.

  International dental journal 20020601

• Substrate recognition by 2-oxoacid:ferredoxin oxidoreductase from Sulfolobus sp. strain 7.

  Biochimica et biophysica acta 20020520

• Lactobacillus reuteri DSM 20016: purification and characterization of a cystathionine gamma-lyase and use as adjunct starter in cheesemaking.

  The Journal of dairy research 20020501

• Synthesis of labeled 1-amino-2-methylenecyclopropane-1-carboxylic acid, an inactivator of 1-aminocyclopropane-1-carboxylate deaminase.

  The Journal of organic chemistry 20020419

• Significance of two distinct types of tryptophan synthase beta chain in Bacteria, Archaea and higher plants.

  Genome biology 20020101

• Molecular cloning and tissue distribution of mammalian L-threonine 3-dehydrogenases.

  BMC biochemistry 20020101

• The human L-threonine 3-dehydrogenase gene is an expressed pseudogene.

  BMC genetics 20020101

• Concomitant extracellular accumulation of alpha-keto acids and higher alcohols by Zygosaccharomyces rouxii.

  Journal of bioscience and bioengineering 20020101

• Ammonia assimilation in Klebsiella pneumoniae F-5-2 that can utilize ammonium and nitrate ions simultaneously: purification and characterization of glutamate dehydrogenase and glutamine synthetase.

  Journal of bioscience and bioengineering 20020101

• Crystallization and some properties of D-lactate dehydrogenase from Staphylococcus sp. LDH-1.

  Journal of bioscience and bioengineering 20020101

• Cobalamin deficiency results in severe metabolic disorder of serine and threonine in rats.

  Biochimica et biophysica acta 20011205

• Threonine metabolism in isolated rat hepatocytes.

  American journal of physiology. Endocrinology and metabolism 20011201

• Glutamate 47 in 1-aminocyclopropane-1-carboxylate synthase is a major specificity determinant.

  Biochemistry 20011016

• Contribution of enzymic alpha, gamma-elimination reaction in detoxification pathway of selenomethionine in mouse liver.

  Toxicology and applied pharmacology 20011001

• Optimized labeling of 13CHD2 methyl isotopomers in perdeuterated proteins: potential advantages for 13C relaxation studies of methyl dynamics of larger proteins.

  Journal of biomolecular NMR 20011001

• Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroxyacid synthase.

  Acta crystallographica. Section D, Biological crystallography 20010901

• 1-Aminocyclopropane-1-carboxylate synthase of Penicillium citrinum: primary structure and expression in Escherichia coli and Saccharomyces cerevisiae.

  Bioscience, biotechnology, and biochemistry 20010701

• Poly(ethylene glycol)-supported bisoxazolines as ligands for catalytic enantioselective synthesis.

  The Journal of organic chemistry 20010504

• Chemo-enzymatic D-enantiomerization of DL-lactate.

  Biotechnology and bioengineering 20010405

• Involvement of branched-chain amino acid aminotransferases in the production of fusel alcohols during fermentation in yeast.

  Applied microbiology and biotechnology 20010401

• Development and evaluation of a boronate inhibitor of gamma-glutamyl transpeptidase.

  Archives of biochemistry and biophysics 20010115

• Artefactual pyruvate and 2-oxobutyrate produced by trimethylsilylation of methylmalonic and ethylmalonic acids in the presence of oxygen.

  Journal of inherited metabolic disease 19991001

• In vivo nephrotoxic action of an isomeric mixture of S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in Fischer-344 rats.

  Toxicology 19910325

• Mechanistic studies on the pyridoxal phosphate enzyme 1-aminocyclopropane-1-carboxylate deaminase from Pseudomonas sp.

  Biochemistry 19811222