61281-37-6 | Schisandrin B

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$61.00	$43.00
5mg	≥98%	in stock	$148.00	$104.00
10mg	≥98%	in stock	$265.00	$186.00
25mg	≥98%	in stock	$580.00	$406.00

Description

• Catalog Number: AI66239
• Chemical Name: Schisandrin B
• CAS Number: 61281-37-6
• Molecular Formula: C23H28O6
• Molecular Weight: 400.4648
• MDL Number: MFCD00887634
• SMILES: COc1cc2C[C@H](C)[C@H](C)Cc3c(c2c(c1OC)OC)c(OC)c1c(c3)OCO1

Computed Properties

• Complexity: 544
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Undefined Atom Stereocenter Count: 2
• XLogP3: 5.1

Literature

• The Nrf2-ARE pathway is associated with Schisandrin b attenuating benzo(a)pyrene-Induced HTR cells damages in vitro.

  Environmental toxicology 20161101

• Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.

  Chemico-biological interactions 20150425

• Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121201

• Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia.

  European journal of pharmacology 20121005

• Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB.

  Free radical biology & medicine 20121001

• Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

  Bioorganic & medicinal chemistry letters 20120901

• Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5.

  International journal of oncology 20120401

• Enrichment and purification of deoxyschizandrin and γ-schizandrin from the extract of Schisandra chinensis fruit by macroporous resins.

  Molecules (Basel, Switzerland) 20120319

• Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes.

  Cell biology international 20120301

• Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice.

  Free radical research 20120101

• Prooxidant-induced glutathione antioxidant response in vitro and in vivo: a comparative study between schisandrin B and curcumin.

  Biological & pharmaceutical bulletin 20120101

• Beneficial effect of (-)schisandrin B against 3-nitropropionic acid-induced cell death in PC12 cells.

  BioFactors (Oxford, England) 20120101

• Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases.

  Oxidative medicine and cellular longevity 20120101

• Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo.

  The American journal of Chinese medicine 20120101

• The protective effects of tea polyphenols and schisandrin B on nephrotoxicity of mercury.

  Biological trace element research 20111201

• Gomisin N has anti-allergic effect and inhibits inflammatory cytokine expression in mouse bone marrow-derived mast cells.

  Immunopharmacology and immunotoxicology 20111201

• Prevention and treatment of doxorubicin-induced cardiotoxicity by dexrazoxane and schisandrin B in rabbits.

  International journal of toxicology 20111201

• Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro.

  Toxicology 20110815

• Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice.

  Free radical research 20110801

• Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts.

  Fitoterapia 20110601

• Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate.

  Naunyn-Schmiedeberg's archives of pharmacology 20110601

• Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells.

  World journal of gastroenterology 20110521

• Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.

  Molecules (Basel, Switzerland) 20110503

• Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.

  Journal of medicinal chemistry 20110414

• Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue.

  Fitoterapia 20110401

• Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells.

  Molecular and cellular biochemistry 20110401

• Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes.

  Free radical research 20110401

• Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells.

  Phytotherapy research : PTR 20110301

• A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein.

  Journal of proteome research 20110107

• Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS.

  Phytochemical analysis : PCA 20110101

• (-)Schisandrin B ameliorates paraquat-induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells.

  BioFactors (Oxford, England) 20110101

• Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells.

  BioFactors (Oxford, England) 20110101

• Schisandrin B prevents doxorubicin-induced chronic cardiotoxicity and enhances its anticancer activity in vivo.

  PloS one 20110101

• Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats.

  Fitoterapia 20101201

• Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae Chinensis extracts) by self-emulsifying drug delivery systems.

  Drug development and industrial pharmacy 20101101

• A new 3,4-seco-lupane-type triterpenoid from the pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms.

  Natural product research 20101001

• Highly sensitive determination of Schisandrin and Schisandrin B in plasma of rats after administration of Wurenchun (Fructus Schisandrae Chinensis Extracts) preparations by LC-ESI-MS/MS.

  Biomedical chromatography : BMC 20100601

• [Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100501

• Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity.

  Methods and findings in experimental and clinical pharmacology 20100401

• A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera.

  Analytica chimica acta 20100303

• [Research on liposoluble ingredients of Quchiling].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

• [Schisandrin B prevents doxorubicin-induced cardiotoxicity in rabbits].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100101

• Schisandrin B-induced glutathione antioxidant response and cardioprotection are mediated by reactive oxidant species production in rat hearts.

  Biological & pharmaceutical bulletin 20100101

• [Changes of lignans' content in stems of Schisandra chinensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

• Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and associated changes in the Ca(2+)-induced mitochondrial permeability transition and mitochondrial membrane potential in AML12 hepatocytes.

  Phytotherapy research : PTR 20091101

• Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091101

• Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity.

  Die Pharmazie 20090701

• [Selection of mobile phases for the determination of gamma-schisandrin and multi-active constituents in Schisandra chinensis and its preparations by high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20090501

• Optimization of extraction and purification of active fractions from Schisandra chinensis (Turcz.) and its osteoblastic proliferation stimulating activity.

  Phytotherapy research : PTR 20090201

• Effect of schisandrin B and sesamin mixture on CCl(4)-induced hepatic oxidative stress in rats.

  Phytotherapy research : PTR 20090201

• Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract.

  Natural product research 20090101

• Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats.

  Biological & pharmaceutical bulletin 20080701

• [Lignans from different processed products of Schisandra chinensis fruits].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080601

• Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes.

  Life sciences 20080523

• Schisandrin B Enhances Renal Mitochondrial Antioxidant Status, Functional and Structural Integrity, and Protects against Gentamicin-Induced Nephrotoxicity in Rats.

  Biological & pharmaceutical bulletin 20080401

• Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice.

  The Journal of pharmacy and pharmacology 20080301

• Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice.

  BioFactors (Oxford, England) 20080101

• Inhibitory effect of schisandrin B on gastric cancer cells in vitro.

  World journal of gastroenterology 20071228

• Schisandrin B prevents doxorubicin-induced cardiotoxicity via enhancing glutathione redox cycling.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20071115

• Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers.

  Biological & pharmaceutical bulletin 20070601

• Schisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1.

  Cancer letters 20070208

• Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver.

  Molecular and cellular biochemistry 20061201

• (-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes.

  Molecular and cellular biochemistry 20060901

• Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats.

  Biogerontology 20060801

• Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein.

  Cancer chemotherapy and pharmacology 20060701

• A novel experimental model of acute hypertriglyceridemia induced by schisandrin B.

  European journal of pharmacology 20060510

• Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells.

  Biochemical pharmacology 20060227

• Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes.

  Pharmacology 20060101

• Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells.

  BioFactors (Oxford, England) 20060101

• Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver.

  Life sciences 20051021

• Schisandrin B--a novel inhibitor of P-glycoprotein.

  Biochemical and biophysical research communications 20050923

• Separation and determination of active components in Schisandra chinensis Baill. and its medicinal preparations by non-aqueous capillary electrophoresis.

  Biomedical chromatography : BMC 20050901

• Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells.

  Molecular and cellular biochemistry 20050801

• [Effects of schisandrin B on reversing multidrug resistance in human breast cancer cells transfected with mdr1 gene].

  Zhonghua yi xue za zhi 20050622

• Preparative separation and purification of deoxyschisandrin and gamma-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography.

  Journal of chromatography. A 20050225

• Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats.

  Molecular and cellular biochemistry 20041101

• Antioxidative effect of schisanhenol on human low density lipoprotein and its quantum chemical calculation.

  Acta pharmacologica Sinica 20040801

• Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.

  Journal of neuroscience research 20040501

• Determination of specific receptor sites for platelet activating factor in bovine neutrophils.

  American journal of veterinary research 20040501

• Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins.

  Free radical biology & medicine 20030815

• Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice.

  BioFactors (Oxford, England) 20030101

• Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury.

  BioFactors (Oxford, England) 20030101

• In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin.

  Planta medica 20021101

• Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain.

  Molecular and cellular biochemistry 20020901

• Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.

  Planta medica 20020301

• [Study on supercritical CO2 fluid extraction and separation of components from fruits of Schisandra sphenanthera].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20011101

• Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts.

  Molecular and cellular biochemistry 20010401

• Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver.

  Cell stress & chaperones 20010101