613-92-3 | N-Hydroxy-benzamidine

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$6.00	$4.00
1g	97%	in stock	$8.00	$6.00
10g	95%	in stock	$23.00	$17.00
25g	97%	in stock	$44.00	$31.00

Description

• Catalog Number: AB70891
• Chemical Name: N-Hydroxy-benzamidine
• CAS Number: 613-92-3
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.1512
• MDL Number: MFCD00031485
• SMILES: O/N=C(/c1ccccc1)\N
• NSC Number: 13999

Computed Properties

• Complexity: 128
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 1.1

Literature

• The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues.

  Chemical research in toxicology 20121119

• Insight into technetium amidoxime complex: oxo technetium(V) complex of N-substituted benzamidoxime as new basic structure for molecular imaging.

  Inorganic chemistry 20110207

• Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).

  The Biochemical journal 20110115

• Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives.

  European journal of medicinal chemistry 20101201

• A novel and specific fluorescence reaction for uracil.

  Analytica chimica acta 20100803

• The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs.

  Journal of medicinal chemistry 20081225

• Involvement of stearoyl-CoA desaturase in the reduction of amidoxime prodrugs.

  Xenobiotica; the fate of foreign compounds in biological systems 20080901

• N,N'-dihydroxyamidines: a new prodrug principle to improve the oral bioavailability of amidines.

  Journal of medicinal chemistry 20071227

• Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme.

  The Journal of biological chemistry 20061117

• Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid).

  Drug metabolism and disposition: the biological fate of chemicals 20051101

• Characterization and partial purification of the rat and human enzyme systems active in the reduction of N-hydroxymelagatran and benzamidoxime.

  Drug metabolism and disposition: the biological fate of chemicals 20050401

• Metabolism of benzamidoxime (N-hydroxyamidine) in human hepatocytes and role of UDP-glucuronosyltransferases.

  Xenobiotica; the fate of foreign compounds in biological systems 20050101

• N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship.

  Journal of medicinal chemistry 20020214

• Phase 2 metabolites of N-hydroxylated amidines (amidoximes): synthesis, in vitro formation by pig hepatocytes, and mutagenicity testing.

  Chemical research in toxicology 20010301