6133-30-8 | (S)-2-Guanidinosuccinic acid

Packsize	Purity	Availability	Price	Discounted Price
50mg	≥95%	in stock	$74.00	$52.00
100mg	≥95%	in stock	$138.00	$97.00
250mg	≥95%	in stock	$196.00	$137.00
500mg	≥95%	in stock	$354.00	$248.00

Description

• Catalog Number: AB46225
• Chemical Name: (S)-2-Guanidinosuccinic acid
• CAS Number: 6133-30-8
• Molecular Formula: C5H9N3O4
• Molecular Weight: 175.1427
• MDL Number: MFCD00055819
• SMILES: NC(=N)N[C@H](C(=O)O)CC(=O)O

Computed Properties

• Complexity: 221
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 4
• XLogP3: -2

Literature

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  PloS one 20120101

• [Analysis of transporter function and development to clinical application].

  Seikagaku. The Journal of Japanese Biochemical Society 20110401

• Simultaneous determination of guanidinosuccinic acid and guanidinoacetic acid in urine using high performance liquid chromatography/tandem mass spectrometry.

  Analytica chimica acta 20100916

• Impact of increasing haemodialysis frequency versus haemodialysis duration on removal of urea and guanidino compounds: a kinetic analysis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090701

• First indications demonstrating the preventive effects of NZ-419, a novel intrinsic antioxidant, on the initiation and/or progression of chronic renal failure in rats.

  Biological & pharmaceutical bulletin 20090701

• Accumulation of methylguanidine and changes in guanidino compound levels in plasma, urine, and kidneys of furosemide-treated rats.

  Metabolism: clinical and experimental 20080601

• Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080401

• Premature aging in uremia.

  Molecular and cellular biochemistry 20070401

• Anisoin: a useful pre-chromatographic derivatization fluorogenic reagent for LC analysis of guanidino compounds.

  Journal of pharmaceutical and biomedical analysis 20060911

• Biochemical validation of a rat model for polycystic kidney disease: comparison of guanidino compound profile with the human condition.

  Kidney international 20060601

• Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions.

  American journal of physiology. Renal physiology 20050401

• GSA: behavioral, histological, electrophysiological and neurochemical effects.

  Physiology & behavior 20050215

• [Guanidino compounds derivatives (guanidinosuccinic acid, guanidinoacetic acid)].

  Nihon rinsho. Japanese journal of clinical medicine 20041101

• Effect of NaCN on currents evoked by uremic retention solutes in dissociated mouse neurons.

  Brain research 20040515

• Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.

  Kidney international 20030501

• Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation.

  Molecular and cellular biochemistry 20030201

• Methyl group deficiency and guanidino production in uremia.

  Molecular and cellular biochemistry 20030201

• Methyl group deficiency States.

  Nephron 20020901

• Long-term effect of partial nephrectomy on biological parameters, kidney histology, and guanidino compound levels in mice.

  Metabolism: clinical and experimental 20011201

• Influence of 72% injury in one kidney on several organs involved in guanidino compound metabolism: a time course study.

  Pflugers Archiv : European journal of physiology 20010701

• Role of nitric oxide in the synthesis of guanidinosuccinic acid, an activator of the N-methyl-D-aspartate receptor.

  Kidney international. Supplement 20010201

• Erythrocyte transketolase activity and guanidino compounds in hemodialysis patients.

  Kidney international. Supplement 20010201