617-35-6 | Ethyl pyruvate

Packsize	Purity	Availability	Price	Discounted Price
25g	95%	in stock	$6.00	$4.00
100g	99%	in stock	$18.00	$12.00
500g	95%	in stock	$50.00	$35.00

Description

• Catalog Number: AB46133
• Chemical Name: Ethyl pyruvate
• CAS Number: 617-35-6
• Molecular Formula: C5H8O3
• Molecular Weight: 116.1152
• MDL Number: MFCD00009123
• SMILES: CCOC(=O)C(=O)C
• NSC Number: 48386

Computed Properties

• Complexity: 106
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• XLogP3: 0.4

Literature

• Ethyl pyruvate protects rats from phosgene-induced pulmonary edema by inhibiting cyclooxygenase2 and inducible nitric oxide synthase expression.

  Journal of applied toxicology : JAT 20130101

• Effects of Ethyl Pyruvate on Allodynia, TNF-α Expression, and Apoptosis in the Dorsal Root Ganglion after Spinal Nerve Ligation Injury.

  The Korean journal of pain 20121001

• Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals.

  Antioxidants & redox signaling 20120915

• HMGB1 in renal ischemic injury.

  American journal of physiology. Renal physiology 20120915

• A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury.

  Fertility and sterility 20120901

• Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation.

  Investigative ophthalmology & visual science 20120901

• Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats.

  Acta gastro-enterologica Belgica 20120901

• Role of high mobility group box 1 (HMGB1) in wound healing.

  The Journal of surgical research 20120701

• Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms.

  Neurochemistry international 20120701

• HMGB1 was a pivotal synergistic effecor for CpG oligonucleotide to enhance the progression of human lung cancer cells.

  Cancer biology & therapy 20120701

• Therapeutic treatment with ethyl pyruvate attenuates the severity of liver injury in rats with severe acute pancreatitis.

  Pancreas 20120701

• Decontamination of green onions and baby spinach by vaporized ethyl pyruvate.

  Journal of food protection 20120601

• Ethyl pyruvate reduces ventilation-induced neutrophil infiltration and oxidative stress.

  Experimental biology and medicine (Maywood, N.J.) 20120601

• Ethyl pyruvate promotes spinal cord repair by ameliorating the glial microenvironment.

  British journal of pharmacology 20120501

• Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo.

  Oncology reports 20120501

• HMGB1: a potential therapeutic target for myocardial ischemia and reperfusion injury.

  International journal of cardiology 20120322

• Ethyl pyruvate ameliorates albuminuria and glomerular injury in the animal model of diabetic nephropathy.

  American journal of physiology. Renal physiology 20120301

• Differences in lipopolysaccharide- and lipoteichoic acid-induced cytokine/chemokine expression.

  Intensive care medicine 20120201

• Peculiarity of methoxy group-substituted phenylhydrazones in Fischer indole synthesis.

  Proceedings of the Japan Academy. Series B, Physical and biological sciences 20120111

• Chiral ammonium-capped rhodium(0) nanocatalysts: synthesis, characterization, and advances in asymmetric hydrogenation in neat water.

  ChemSusChem 20120109

• Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats.

  Molecular biology reports 20120101

• An in vitro spinal cord slice preparation for recording from lumbar motoneurons of the adult mouse.

  Journal of neurophysiology 20120101

• Effects of continuous erythropoietin receptor activator in sepsis-induced acute kidney injury and multi-organ dysfunction.

  PloS one 20120101

• Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose.

  Critical care (London, England) 20120101

• Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?

  Critical care (London, England) 20120101

• Reperfusion strategies in the management of extremity vascular injury with ischaemia.

  The British journal of surgery 20120101

• Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate.

  Experimental oncology 20120101

• Toll-like receptors in ischaemia and its potential role in the pathophysiology of muscle damage in critical limb ischaemia.

  Cardiology research and practice 20120101

• Small interference RNA targeting TLR4 gene effectively attenuates pulmonary inflammation in a rat model.

  Journal of biomedicine & biotechnology 20120101

• Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.

  Mediators of inflammation 20120101

• Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity.

  PloS one 20120101

• Therapeutic effect of captopril, pentoxifylline, and cordyceps sinensis in pre-hepatic portal hypertensive rats.

  Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20120101

• Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation.

  Molecular pain 20120101

• Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury.

  Frontiers in physiology 20120101

• Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.

  Clinical & developmental immunology 20120101

• Dengue virus infection mediates HMGB1 release from monocytes involving PCAF acetylase complex and induces vascular leakage in endothelial cells.

  PloS one 20120101

• Uric acid and HMGB1 are involved in the induction of autoantibodies elicited in mice infected with mouse hepatitis virus A59.

  Autoimmunity 20111201

• [Ethyl pyruvate inhibited HMGB1 expression induced by LPS in macrophages].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20111201

• Inhaled nitric oxide aggravates phosgene model of acute lung injury.

  Inhalation toxicology 20111101

• Ethyl 2-[(carbamothioyl-amino)-imino]-propano-ate.

  Acta crystallographica. Section E, Structure reports online 20110801

• Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine.

  Nutrients 20110801

• Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease.

  Journal of immunology (Baltimore, Md. : 1950) 20110715

• Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats.

  Investigative ophthalmology & visual science 20110701

• Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1.

  Toxicology and applied pharmacology 20110615

• In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats.

  Thrombosis research 20110601

• Kainic Acid-induced neurotoxicity: targeting glial responses and glia-derived cytokines.

  Current neuropharmacology 20110601

• Ethyl pyruvate reduces acute lung injury via regulation of iNOS and HO-1 expression in endotoxemic rats.

  The Journal of surgical research 20110515

• Ethyl pyruvate decreases proinflammatory gene expression in lipopolysaccharide-stimulated equine monocytes.

  Veterinary immunology and immunopathology 20110515

• Preliminary safety and biological efficacy studies of ethyl pyruvate in normal mature horses.

  Equine veterinary journal 20110501

• Alternative fluids for prehospital resuscitation: 'pharmacological' resuscitation fluids.

  The Journal of trauma 20110501

• Ethyl pyruvate, an anti-inflammatory agent, inhibits tumor angiogenesis through inhibition of the NF-κB signaling pathway.

  Cancer letters 20110428

• Inhibitory mechanism of MMP-9 gene expression by ethyl pyruvate in lipopolysaccharide-stimulated BV2 microglial cells.

  Neuroscience letters 20110408

• Pyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production.

  Amino acids 20110401

• High-mobility group box 1, oxidative stress, and disease.

  Antioxidants & redox signaling 20110401

• The first case of competitive heterogeneously catalyzed enantioselective hydrogenation of ketones.

  Chemical communications (Cambridge, England) 20110207

• Interaction of ethyl pyruvate in vitro with NF-κB subunits, RelA and p50.

  European journal of pharmacology 20110110

• Effects of ethyl pyruvate and other α-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion.

  The Journal of surgical research 20110101

• Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes.

  Endocrinology 20110101

• Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion.

  The Journal of trauma 20110101

• A hepatic protein, fetuin-A, occupies a protective role in lethal systemic inflammation.

  PloS one 20110101

• Higher hypochlorous acid scavenging activity of ethyl pyruvate compared to its sodium salt.

  Bioscience, biotechnology, and biochemistry 20110101

• The role of receptor for advanced glycation endproducts (RAGE) in infection.

  Critical care (London, England) 20110101

• Systemically administered ligands of Toll-like receptor 2, -4, and -9 induce distinct inflammatory responses in the murine lung.

  Mediators of inflammation 20110101

• Trauma is danger.

  Journal of translational medicine 20110101

• An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.

  PloS one 20110101

• Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-κB pathway after traumatic brain injury in the rat.

  Mediators of inflammation 20110101

• Prevention of cataract in diabetic mice by topical pyruvate.

  Clinical ophthalmology (Auckland, N.Z.) 20110101

• Tissue factor, blood coagulation, and beyond: an overview.

  International journal of inflammation 20110101

• Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.

  International journal of molecular sciences 20110101

• Differential regional expression patterns of α-synuclein, TNF-α, and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment.

  Journal of neuroinflammation 20110101

• The beneficial effect of direct peritoneal resuscitation on septic shock in rats.

  Journal of biomedicine & biotechnology 20110101

• Using Complementary and Alternative Medicines to Target the Host Response during Severe Influenza.

  Evidence-based complementary and alternative medicine : eCAM 20101201

• HMGB1 activates nuclear factor-κB signaling by RAGE and increases the production of TNF-α in human umbilical vein endothelial cells.

  Immunobiology 20101201

• Transglutaminase 2 expression induced by lipopolysaccharide stimulation together with NO synthase induction in cultured astrocytes.

  Neurochemistry international 20101201

• [Effect of ethyl pyruvate on expression of inflammatory factors and mitogen-activated protein kinase proteins in renal ischemic/reperfusion injury in BABL/c mice].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101201

• Ethyl pyruvate has anti-inflammatory and delayed myocardial protective effects after regional ischemia/reperfusion injury.

  Yonsei medical journal 20101101

• Ethyl pyruvate diminishes the endotoxin-induced inflammatory response of bovine mammary endothelial cells.

  Journal of dairy science 20101101

• Ethyl pyruvate downregulates tumor necrosis factor alpha and interleukin (IL)-6 and upregulates IL-10 in lipopolysaccharide-stimulated canine peripheral blood mononuclear cells.

  The Journal of veterinary medical science 20101001

• Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat.

  Experimental neurology 20101001

• Cell to Cell Interaction Can Activate Membrane-bound APRIL Which Are Expressed on Inflammatory Macrophages.

  Immune network 20101001

• Ethyl pyruvate stabilizes hypoxia-inducible factor 1 alpha via stimulation of the TCA cycle.

  Cancer letters 20100928

• HMGB1 release and redox regulates autophagy and apoptosis in cancer cells.

  Oncogene 20100923

• Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage.

  Shock (Augusta, Ga.) 20100801

• Inhibition by ethyl pyruvate of the nuclear translocation of nuclear factor-kappaB in cultured lung epithelial cells.

  Pulmonary pharmacology & therapeutics 20100801

• The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds.

  Biochemical pharmacology 20100715

• Association between high-mobility group box-1 protein release and immune function of dendritic cells in thermal injury.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20100701

• Responses of cultured human keratocytes and myofibroblasts to ethyl pyruvate: a microarray analysis of gene expression.

  Investigative ophthalmology & visual science 20100601

• Ethyl pyruvate prevents intestinal inflammatory response and oxidative stress in a rat model of extrahepatic cholestasis.

  The Journal of surgical research 20100515

• Diastereoselective synthesis of fused [1,3]oxazines from ethyl pyruvate, activated acetylenes and N-heterocycles.

  Molecular diversity 20100501

• Hypertonic sodium pyruvate solution is more effective than Ringer's ethyl pyruvate in the treatment of hemorrhagic shock.

  Shock (Augusta, Ga.) 20100501

• Intraocular penetration of pyruvate following its topical administration in mice.

  Molecular and cellular biochemistry 20100501

• Cancer and inflammation: promise for biologic therapy.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20100501

• Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate.

  Magnetic resonance in medicine 20100501

• Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model.

  Biochemical and biophysical research communications 20100409

• [Influence of splenic high mobility group box-1 protein on immune function of regulatory T lymphocytes in scald rats].

  Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20100401

• Ethyl (2E)-2-(hydroxy-imino)propanoate.

  Acta crystallographica. Section E, Structure reports online 20100401

• Role of high-mobility group box 1 protein in the pathogenesis of intestinal barrier injury in rats with severe acute pancreatitis.

  Pancreas 20100301

• Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms.

  Neurobiology of disease 20100301

• Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate.

  Cancer research 20100301

• Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction.

  Chemical communications (Cambridge, England) 20100227

• Ethyl pyruvate inhibits peroxynitrite-induced DNA damage and hydroxyl radical generation: implications for neuroprotection.

  Neurochemical research 20100201

• Natural alkaloids and synthetic relatives as chiral templates of the Orito's reaction.

  Chirality 20100101

• Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain.

  Neurotoxicity research 20100101

• LucidDraw: efficiently visualizing complex biochemical networks within MATLAB.

  BMC bioinformatics 20100101

• Peritoneal inflammation after twenty-week exposure to dialysis solution: effect of solution versus catheter-foreign body reaction.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20100101

• Proline-Glycine-Proline (PGP) and High Mobility Group Box Protein-1 (HMGB1): Potential Mediators of Cystic Fibrosis Airway Inflammation.

  The open respiratory medicine journal 20100101

• Novel insights for systemic inflammation in sepsis and hemorrhage.

  Mediators of inflammation 20100101

• DAMPening inflammation by modulating TLR signalling.

  Mediators of inflammation 20100101

• Ethyl pyruvate therapy attenuates experimental severe arthritis caused by type II collagen (CII) in the mouse (CIA).

  International journal of immunopathology and pharmacology 20100101

• Current and emerging strategies for the treatment and management of systemic lupus erythematosus based on molecular signatures of acute and chronic inflammation.

  Journal of inflammation research 20100101

• Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.

  American journal of respiratory cell and molecular biology 20091201

• Ethyl pyruvate enhances intra-resuscitation hemodynamics in prolonged ventricular fibrillation arrest.

  Resuscitation 20091201

• Autophagy inhibition in combination cancer treatment.

  Current opinion in investigational drugs (London, England : 2000) 20091201

• Diastereoselective synthesis of fused [1,3]thiazolo[1,3]oxazins and [1,3]oxazino[2,3-b][1,3]benzothiazoles.

  Molecular diversity 20091101

• Modulation of intracellular ROS levels by TIGAR controls autophagy.

  The EMBO journal 20091007

• Shape-selective enantioselective hydrogenation on Pt nanoparticles.

  Journal of the American Chemical Society 20090902

• Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis.

  Journal of leukocyte biology 20090901

• Ethyl pyruvate administration inhibits hepatic tumor growth.

  Journal of leukocyte biology 20090901

• Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos.

  Molecular cancer therapeutics 20090901

• Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury.

  Shock (Augusta, Ga.) 20090801

• Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma.

  Naunyn-Schmiedeberg's archives of pharmacology 20090801

• Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate.

  Expert opinion on investigational drugs 20090801

• [Effects of ethyl pyruvate on injuries of sepsis in mice].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20090801

• Ethyl pyruvate modulates adhesive and secretory reactions in human lung epithelial cells.

  Life sciences 20090605

• A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass.

  Journal of cardiothoracic and vascular anesthesia 20090601

• Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits.

  Anesthesiology 20090601

• Anti-inflammatory resuscitation improves survival in hemorrhage with trauma.

  The Journal of trauma 20090601

• The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages: Implication for Atherosclerosis.

  Immune network 20090601

• Ethyl pyruvate ameliorates liver injury secondary to severe acute pancreatitis.

  The Journal of surgical research 20090515

• Effect of ethyl pyruvate on physical and immunological barriers of the small intestine in a rat model of sepsis.

  The Journal of trauma 20090501

• Neuroprotective effects of ethyl pyruvate on brain energy metabolism after ischemia-reperfusion injury: a 31P-nuclear magnetic resonance study.

  Neurochemical research 20090401

• Ethyl pyruvate improves survival in awake hemorrhage.

  Journal of molecular medicine (Berlin, Germany) 20090401

• The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats.

  Shock (Augusta, Ga.) 20090301

• Ethyl pyruvate protects colonic anastomosis from ischemia-reperfusion injury.

  Surgical innovation 20090301

• Anti-inflammatory adjuvant in resuscitation fluids improves survival in hemorrhage.

  Critical care medicine 20090301

• Would you like your colloid straight or with a twist of an anti-inflammatory antioxidant?

  Critical care medicine 20090301

• Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress.

  Neurochemistry international 20090201

• Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice.

  Critical care medicine 20090101

• Heme Oxygenase-1 is an Essential Cytoprotective Component in Oxidative Tissue Injury Induced by Hemorrhagic Shock.

  Journal of clinical biochemistry and nutrition 20090101

• Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model.

  Respiratory research 20090101

• The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2.

  Cardiology research and practice 20090101

• Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice.

  American journal of physiology. Renal physiology 20081201

• Stereoselective reduction of carbonyl compounds with Actinomycete: purification and characterization of three alpha-keto ester reductases from Streptomyces avermitilis.

  Bioscience, biotechnology, and biochemistry 20081201

• 1-(1-Naphthyl)ethylamine adsorption on platinum surfaces: on the mechanism of chiral modification in catalysis.

  Journal of the American Chemical Society 20081105

• The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in rats.

  Clinical toxicology (Philadelphia, Pa.) 20081101

• Relationship between high-mobility group box 1 protein release and T-cell suppression in rats after thermal injury.

  Shock (Augusta, Ga.) 20081001

• The role of high mobility group box1 in pulmonary fibrosis.

  American journal of respiratory cell and molecular biology 20081001

• Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia.

  Free radical biology & medicine 20081001

• Polar [3 + 2] cycloaddition of ketones with electrophilically activated carbonyl ylides. Synthesis of spirocyclic dioxolane indolinones.

  Organic & biomolecular chemistry 20080907

• Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors.

  Biochemical pharmacology 20080901

• The role of high-mobility group box-1 in renal ischemia and reperfusion injury and the effect of ethyl pyruvate.

  Transplantation proceedings 20080901

• Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats.

  World journal of gastroenterology 20080728

• Systemic release of high mobility group box 1 protein during severe murine influenza.

  Journal of immunology (Baltimore, Md. : 1950) 20080715

• Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-kappaB pathway.

  British journal of pharmacology 20080701

• Synphos modified Pt nanoclusters, their heterogenization by silica sol-gel entrapment, and catalytic activity in hydrogenolysis of bicyclo[2.2.2]oct-7-enes and hydrogenation of ethyl pyruvate.

  Nanotechnology 20080604

• Effects of ethyl pyruvate on myocardial apoptosis and expression of Bcl-2 and Bax proteins after ischemia-reperfusion in rats.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080601

• Synthesis and biological activity of functionalized indole-2-carboxylates, triazino- and pyridazino-indoles.

  Archiv der Pharmazie 20080501

• Ethyl pyruvate decreased early nuclear factor-kappaB levels but worsened survival in lipopolysaccharide-challenged mice.

  Critical care medicine 20080401

• Bull's eye missed by the magic bullet: preclinical investigations, publication bias, and promising new interventions.

  Critical care medicine 20080401

• Ethyl pyruvate reduces germ cell-specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion.

  Journal of pediatric surgery 20080401

• Targeting the lipopolysaccharides: still a matter of debate?

  Current opinion in anaesthesiology 20080401

• Ethyl pyruvate.

  Current opinion in anaesthesiology 20080401

• Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine expression.

  The Journal of surgical research 20080301

• [Protective effect of ethyl pyruvate on barrier function of intestinal mucosa in dogs with septic shock].

  Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 20080301

• Sepsis: from bench to bedside.

  Clinics (Sao Paulo, Brazil) 20080201

• The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury.

  The Journal of surgical research 20080101

• [Effect of ethyl pyruvate on indices of tissue oxygenation and perfusion in dogs with septic shock].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20080101

• Protective effects of ethyl pyruvate treatment on paraquat-intoxicated rats.

  Human & experimental toxicology 20080101

• Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation.

  Theoretical biology & medical modelling 20080101

• Bench-to-bedside review: latest results in hemorrhagic shock.

  Critical care (London, England) 20080101

• Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC.

  International journal of biological sciences 20080101

• Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity.

  PloS one 20080101

• Management of sepsis.

  BMJ (Clinical research ed.) 20071103

• Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo.

  Shock (Augusta, Ga.) 20071101

• Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation.

  Radiation research 20071101

• Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices.

  Anesthesiology 20071001

• Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis.

  Pancreas 20071001

• The protective effect of ethyl pyruvate on lung injury after burn in rats.

  Saudi medical journal 20071001

• [Effect of ethyl pyruvate on renal high mobility group box-1 protein expression and acute kidney injury in rats with delayed resuscitation after thermal injury].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20070901

• Oxidative damage in rat erythrocyte membranes following ethanol intake: effect of ethyl pyruvate.

  Chemico-biological interactions 20070830

• Role of guiding groups in cinchona-modified platinum for controlling the sense of enantiodifferentiation in the hydrogenation of ketones.

  Journal of the American Chemical Society 20070829

• Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells.

  International journal of molecular medicine 20070801

• [Advances in high mobility group box-1 protein mediated multiple organ dysfunction and its potential interventional strategies].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20070801

• Ethyl pyruvate: a novel anti-inflammatory agent.

  Journal of internal medicine 20070401

• Ethyl pyruvate: a novel treatment for sepsis.

  Current drug targets 20070401

• Enantioselective hydrogenation of ethyl pyruvate over diop modified Pt nanoclusters. Determination of geometry of the ligand adsorption mode via DRIFTS.

  Physical chemistry chemical physics : PCCP 20070221

• Beneficial effects of ethyl pyruvate in septic shock from peritonitis.

  Archives of surgery (Chicago, Ill. : 1960) 20070201

• Promising therapeutic agents for sepsis.

  Trends in microbiology 20070101

• Protective effect of ethyl pyruvate on msP rat leukocytes damaged by alcohol intake.

  Journal of applied toxicology : JAT 20070101

• HMGB1 as a potential therapeutic target.

  Novartis Foundation symposium 20070101

• Ethyl pyruvate: a novel treatment for sepsis.

  Novartis Foundation symposium 20070101

• The first organocatalytic carbonyl-ene reaction: isomerisation-free C-C bond formations catalysed by H-bonding thio-ureas.

  Beilstein journal of organic chemistry 20070101

• Bench-to-bedside review: High-mobility group box 1 and critical illness.

  Critical care (London, England) 20070101

• A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1.

  PloS one 20070101

• Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy.

  Journal of burns and wounds 20070101

• Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells.

  Thrombosis and haemostasis 20061201

• Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus.

  Journal of neuroscience research 20061115

• Haemodynamic and metabolic effects of resuscitation with Ringer's ethyl pyruvate in the acute phase of porcine endotoxaemic shock.

  Acta anaesthesiologica Scandinavica 20061101

• [Relation between level of expression of high mobility group protein B1 in hepatic tissue with the severity and prognosis of sepsis in rat].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20061101

• Is pyruvate an endogenous anti-inflammatory molecule?

  Nutrition (Burbank, Los Angeles County, Calif.) 20060901

• Introduction to serial reviews on redox signaling in immune function and cellular responses in lung injury and diseases.

  Free radical biology & medicine 20060701

• Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule.

  Medical science monitor : international medical journal of experimental and clinical research 20060501

• Determination of geometric orientation of adsorbed cinchonidine on Pt and Fe and quiphos on Pt nanoclusters via DRIFTS.

  Physical chemistry chemical physics : PCCP 20060321

• [Effect of treatment with ethyl pyruvate on multiple organ dysfunction and mortality following delayed resuscitation after burn injury in rat].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060301

• [Effect of ethyl pyruvate on peroxidation injury of intestinal mucosa in rats with severe abdominal infection].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060301

• Treatment of severe sepsis: where next? Current and future treatment approaches after the introduction of drotrecogin alfa.

  Vascular health and risk management 20060301

• Highly enantioselective direct reductive coupling of conjugated alkynes and alpha-ketoesters via rhodium-catalyzed asymmetric hydrogenation.

  Journal of the American Chemical Society 20060125

• Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20060101

• Bench-to-bedside review: critical illness-associated cognitive dysfunction--mechanisms, markers, and emerging therapeutics.

  Critical care (London, England) 20060101

• The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro.

  Biochemical pharmacology 20051125

• Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain.

  Brain research 20051026

• Efficiency in isotetronic acid synthesis via a diamine-acid couple catalyzed ethyl pyruvate homoaldol reaction.

  Organic letters 20051013

• Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window.

  Stroke 20051001

• The cytokine activity of HMGB1--extracellular escape of the nuclear protein.

  Chang Gung medical journal 20051001

• Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia.

  Critical care medicine 20050901

• Neonicotinoid nitroguanidine insecticide metabolites: synthesis and nicotinic receptor potency of guanidines, aminoguanidines, and their derivatives.

  Chemical research in toxicology 20050901

• Ethyl pyruvate ameliorates ileus induced by bowel manipulation in mice.

  Surgery 20050901

• [Effects of ethyl pyruvate on splenocyte proliferation and apoptosis in burn rats with delayed resuscitation].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20050701

• Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice.

  Kidney international 20050601

• Oxoester oxidoreductase activities in new isolates of Pichia anomala from apple, grape and cane juices.

  FEMS yeast research 20050401

• Future strategies in the treatment of acute renal failure: growth factors, stem cells, and other novel therapies.

  Current opinion in pediatrics 20050401

• Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65.

  The Journal of pharmacology and experimental therapeutics 20050301

• Ringer's ethyl pyruvate in hemorrhagic shock and resuscitation does not improve early hemodynamics or tissue energetics.

  Shock (Augusta, Ga.) 20050301

• Ethyl pyruvate enhances ATP levels, reduces oxidative stress and preserves cardiac function in a rat model of off-pump coronary bypass.

  Heart, lung & circulation 20050301

• Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis.

  European journal of pharmacology 20050131

• Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis.

  Transplantation 20050127

• [Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20050101

• Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate.

  Critical care (London, England) 20050101

• Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis.

  Shock (Augusta, Ga.) 20041001

• Synthesis of cladobotryal, CJ16,169, and CJ16,170.

  Organic letters 20040819

• Native versus recombinant high-mobility group B1 proteins: functional activity in vitro.

  Inflammation 20040801

• Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis.

  Critical care medicine 20040701

• Ethyl pyruvate: a simple solution?

  Critical care medicine 20040701

• Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia.

  The Journal of thoracic and cardiovascular surgery 20040501

• Ethyl pyruvate: a novel treatment for sepsis and shock.

  Minerva anestesiologica 20040501

• Direct catalytic asymmetric aldol reactions of pyruvates: scope and mechanism.

  Organic & biomolecular chemistry 20040407

• Identification of catalyst surface species during asymmetric platinum-catalysed hydrogenation in a 'supercritical' solvent.

  Chemical communications (Cambridge, England) 20040321

• Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells.

  The Journal of pharmacology and experimental therapeutics 20040101

• 8th Annual Toronto Critical Care Medicine Symposium, 30 October-1 November 2003, Toronto, Ontario, Canada.

  Critical care (London, England) 20040101

• Investigation of chiral reactions: the structural detection of new hydrogenated isocinchona alkaloids from mixtures without isolation using electrospray ionization tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction.

  Shock (Augusta, Ga.) 20031201

• Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion.

  Intensive care medicine 20031101

• Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice.

  Kidney international 20031101

• Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice.

  The Journal of laboratory and clinical medicine 20031101

• Catalytic enantioselective transamination of alpha-keto esters: an organic approach to enzymatic reactions.

  Chemical communications (Cambridge, England) 20031021

• Ringer's ethyl pyruvate solution: a novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis.

  The Journal of trauma 20030501

• Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers.

  The Journal of pharmacology and experimental therapeutics 20030101

• Ethyl pyruvate: a novel anti-inflammatory agent.

  Critical care medicine 20030101

• Hydrogenation of cinchona alkaloids over supported Pt catalyst.

  Chirality 20030101

• Investigations in chiral reactions: identification of new adducts in the reactions of ethyl pyruvate with acetic anhydride and pyridine.

  Rapid communications in mass spectrometry : RCM 20030101

• Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock.

  Shock (Augusta, Ga.) 20021201

• Possible mechanism for involvement of cysteine in aroma production in wine.

  Journal of agricultural and food chemistry 20021009

• Structural characterization of acetylpyridinium-ethyl pyruvate adducts by electrospray ionization mass spectrometry.

  Journal of mass spectrometry : JMS 20021001

• Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock.

  American journal of physiology. Gastrointestinal and liver physiology 20020701

• Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats.

  Shock (Augusta, Ga.) 20020601

• Unexpected change of the sense of the enantioselective hydrogenation of ethyl pyruvate catalyzed by a Pt-alumina-cinchona alkaloid system.

  Chemical communications (Cambridge, England) 20020521

• Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution.

  Current opinion in clinical nutrition and metabolic care 20020301

• A highly atom efficient, solvent promoted addition of tetraallylic, tetraallenic, and tetrapropargylic stannanes to carbonyl compounds.

  The Journal of organic chemistry 20011116

• Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats.

  Critical care medicine 20010801

• Ringer's ethyl pyruvate solution: a novel resuscitation fluid.

  Minerva anestesiologica 20010401