623142-96-1 | Ki20227

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$43.00	$30.00
5mg	≥98%	in stock	$159.00	$111.00
10mg	98%	in stock	$249.00	$174.00
25mg	98%	in stock	$422.00	$295.00
500mg	98% by HPLC	in stock	$6,165.00	$4,315.00
1000mg	98% by HPLC	in stock	$9,831.00	$6,882.00

Description

• Catalog Number: AG65566
• Chemical Name: Ki20227
• CAS Number: 623142-96-1
• Molecular Formula: C24H24N4O5S
• Molecular Weight: 480.5362
• MDL Number: MFCD12024693
• SMILES: COc1cc(ccc1NC(=O)NC(c1nccs1)C)Oc1ccnc2c1cc(OC)c(c2)OC

Computed Properties

• Complexity: 661
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 8
• Undefined Atom Stereocenter Count: 1
• XLogP3: 3.6

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Comprehensive analysis of kinase inhibitor selectivity.

  Nature biotechnology 20111030

• Inhibition of the c-fms proto-oncogene autocrine loop and tumor phenotype in glucocorticoid stimulated human breast carcinoma cells.

  Breast cancer research and treatment 20110901

• Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

  Chemistry & biology 20101124

• The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis.

  Journal of neuroimmunology 20080301

• The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model.

  European journal of immunology 20080101

• A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.

  Molecular cancer therapeutics 20061101