63-37-6 | 5'-Cytidylic acid

Packsize	Purity	Availability	Price	Discounted Price
5g	95%	in stock	$7.00	$5.00
10g	95%	in stock	$10.00	$7.00
25g	95%	in stock	$18.00	$13.00
100g	98%(HPLC)	in stock	$70.00	$49.00
500g	95%	in stock	$143.00	$101.00

Description

• Catalog Number: AI54026
• Chemical Name: 5'-Cytidylic acid
• CAS Number: 63-37-6
• Molecular Formula: C9H14N3O8P
• Molecular Weight: 323.1965
• MDL Number: MFCD00006544
• SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1n1ccc(nc1=O)N)COP(=O)(O)O

Computed Properties

• Complexity: 531
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 4
• XLogP3: -3.4

Literature

• Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme.

  ACS chemical biology 20170818

• Application of ProTide technology to gemcitabine: a successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development.

  Journal of medicinal chemistry 20140227

• Characterization of the CDP-D-mannitol biosynthetic pathway in Streptococcus pneumoniae 35A.

  Glycobiology 20121201

• Amino acid residues important for CMP-sialic acid recognition by the CMP-sialic acid transporter: analysis of the substrate specificity of UDP-galactose/CMP-sialic acid transporter chimeras.

  Glycobiology 20121201

• Cytotoxicity of new duplex drugs linking 3'-C-ethynylcytidine and 5-fluor-2'-deoxyuridine against human melanoma cells.

  International journal of cancer 20121101

• Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging.

  Chemical communications (Cambridge, England) 20121009

• Cytosine to uracil conversion through hydrolytic deamination of cytidine monophosphate hydroxy-alkylated on the amino group: a liquid chromatography--electrospray ionization--mass spectrometry investigation.

  Journal of mass spectrometry : JMS 20121001

• A high-throughput screen for polysialyltransferase activity.

  Analytical biochemistry 20120801

• Association of a multi-synthetase complex with translating ribosomes in the archaeon Thermococcus kodakarensis.

  FEBS letters 20120730

• Construction of supramolecular helical nanofibers using renewable biomaterials: self-assembly of a cytidylic acid-appended bolaamphiphile in lemon juice.

  Chemical communications (Cambridge, England) 20120707

• Thermal diffusion of nucleotides.

  The journal of physical chemistry. B 20120628

• Ultrafast IR spectroscopy of polymeric cytosine nucleic acids reveal the long-lived species is due to a localised state.

  Physical chemistry chemical physics : PCCP 20120514

• Hybrid- and complex-type N-glycans are not essential for Newcastle disease virus infection and fusion of host cells.

  Glycobiology 20120301

• Comparison of the quantitative performances and measurement uncertainty estimates obtained during method validation versus routine applications of a novel hydrophilic interaction chromatography method for the determination of cidofovir in human plasma.

  Journal of pharmaceutical and biomedical analysis 20120105

• UTP affects the Schwannoma cell line proteome through P2Y receptors leading to cytoskeletal reorganisation.

  Proteomics 20120101

• Detailed mitochondrial phenotyping by high resolution metabolomics.

  PloS one 20120101

• Sialyl residues modulate LPS-mediated signaling through the Toll-like receptor 4 complex.

  PloS one 20120101

• Functional characterization of EngA(MS), a P-loop GTPase of Mycobacterium smegmatis.

  PloS one 20120101

• The Chlamydia psittaci genome: a comparative analysis of intracellular pathogens.

  PloS one 20120101

• The effects of addition of mononucleotides on Sma nuc endonuclease activity.

  TheScientificWorldJournal 20120101

• Analysis of 5'-mononucleotides in infant formula and adult/pediatric nutritional formula by liquid chromatography: First Action 2011.20.

  Journal of AOAC International 20120101

• HILIC-MS/MS method for the quantitation of nucleotides in infant formula and adult nutritional formula: First Action 2011.21.

  Journal of AOAC International 20120101

• A novel cytarabine crystalline lipid prodrug: hexadecyloxypropyl cytarabine 3',5'-cyclic monophosphate for proliferative vitreoretinopathy.

  Molecular vision 20120101

• Loss-of-function mutation in bi-functional marine bacterial sialyltransferase.

  Bioscience, biotechnology, and biochemistry 20120101

• Evaluation of a UCMK/dCK fusion enzyme for gemcitabine-mediated cytotoxicity.

  Biochemical and biophysical research communications 20111209

• Structure of the 2-aminopurine-cytosine base pair formed in the polymerase active site of the RB69 Y567A-DNA polymerase.

  Biochemistry 20111122

• Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni.

  The Journal of biological chemistry 20111014

• Adsorption of ribose nucleotides on manganese oxides with varied mn/o ratio: implications for chemical evolution.

  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20111001

• Unilateral facial paralysis caused by Ramsay Hunt syndrome.

  The Journal of craniofacial surgery 20110901

• Enhanced sialylation of recombinant human erythropoietin in Chinese hamster ovary cells by combinatorial engineering of selected genes.

  Glycobiology 20110801

• Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or taxane/cisplatinum.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110801

• Epigenetic inactivation of PCDH10 in human prostate cancer cell lines.

  Cell biology international 20110701

• Unique self-anhydride formation in the degradation of cytidine-5'-monophosphosialic acid (CMP-Neu5Ac) and cytidine-5'-diphosphosialic acid (CDP-Neu5Ac) and its application in CMP-sialic acid analogue synthesis.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110627

• Synthesis of new chiral heterocyclic Schiff base modulated Cu(II)/Zn(II) complexes: their comparative binding studies with CT-DNA, mononucleotides and cleavage activity.

  Journal of photochemistry and photobiology. B, Biology 20110503

• Biochemical properties of Candida parapsilosis ecto-5'-nucleotidase and the possible role of adenosine in macrophage interaction.

  FEMS microbiology letters 20110401

• Profile of nucleotides and nucleosides in Taiwanese human milk.

  Pediatrics and neonatology 20110401

• CDP-choline-induced contractions in the mouse gastric fundus through purinoceptors and Rho/Rho-kinase signalling.

  Life sciences 20110314

• Single nucleotide polymorphisms of the IL28B and sustained virologic response of patients with chronic hepatitis C to PEG-interferon/ribavirin therapy: A meta-analysis: Meta-analysis of IL28B.

  Hepatitis monthly 20110301

• Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.

  Journal of medicinal chemistry 20110113

• Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle.

  Journal of clinical biochemistry and nutrition 20110101

• Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling.

  Nutrition journal 20110101

• Enzymes are enriched in bacterial essential genes.

  PloS one 20110101

• Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections.

  Frontiers in microbiology 20110101

• Molecular characterization of the uncultivatable hemotropic bacterium Mycoplasma haemofelis.

  Veterinary research 20110101

• Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors.

  PloS one 20110101

• Evidence for a two-metal-ion mechanism in the cytidyltransferase KdsB, an enzyme involved in lipopolysaccharide biosynthesis.

  PloS one 20110101

• Genome of Mycoplasma haemofelis, unraveling its strategies for survival and persistence.

  Veterinary research 20110101

• Towards in vivo imaging of cancer sialylation.

  International journal of molecular imaging 20110101

• Open-ITC: an alternate computational approach to analyze the isothermal titration calorimetry data of complex binding mechanisms.

  Journal of molecular recognition : JMR 20110101

• Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.

  The Journal of biological chemistry 20101105

• Clozapine treatment causes oxidation of proteins involved in energy metabolism in lymphoblastoid cells: a possible mechanism for antipsychotic-induced metabolic alterations.

  Journal of psychiatric practice 20100901

• [Determination of nucleotides in infant formula milk powder by ion chromatography].

  Se pu = Chinese journal of chromatography 20100901

• The crystal structure of ribonuclease A in complex with thymidine-3'-monophosphate provides further insight into ligand binding.

  Proteins 20100815

• Ion-pair high-performance liquid chromatography with diode array detection coupled to dual electrospray atmospheric pressure chemical ionization time-of-flight mass spectrometry for the determination of nucleotides in baby foods.

  Journal of chromatography. A 20100806

• Chemoenzymatic synthesis and enzymatic analysis of 8-modified cytidine monophosphate-sialic acid and sialyl lactose derivatives.

  Journal of the American Chemical Society 20100714

• Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.

  Biochemistry 20100706

• Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis.

  The FEBS journal 20100701

• Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.

  Nature 20100610

• Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling.

  Analytical chemistry 20100601

• Nucleotides and nucleosides in ovine and caprine milk during lactation.

  Journal of dairy science 20100601

• In planta protein sialylation through overexpression of the respective mammalian pathway.

  The Journal of biological chemistry 20100521

• Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5'-monophosphates bearing a biodegradable protecting group.

  Organic & biomolecular chemistry 20100507

• Characterization of a putative 3-deoxy-D-manno-2-octulosonic acid (Kdo) transferase gene from Arabidopsis thaliana.

  Glycobiology 20100501

• Site-specific labeling of nucleotides for making RNA for high resolution NMR studies using an E. coli strain disabled in the oxidative pentose phosphate pathway.

  Journal of biomolecular NMR 20100501

• Characterization of two isotypes of l-threonine dehydratase from Entamoeba histolytica.

  Molecular and biochemical parasitology 20100401

• Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2'-C-methyl-cytidine to its 5'-monophosphate metabolite.

  Antiviral research 20100301

• Modulation of human UMP/CMP kinase affects activation and cellular sensitivity of deoxycytidine analogs.

  Biochemical pharmacology 20100201

• Non-homologous isofunctional enzymes: a systematic analysis of alternative solutions in enzyme evolution.

  Biology direct 20100101

• A liquid chromatographic method for routine analysis of 5'-mononucleotides in pediatric formulas.

  Journal of AOAC International 20100101

• Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species.

  BMC genomics 20100101

• Cloning and biochemical characterization of a novel lipolytic gene from activated sludge metagenome, and its gene product.

  Microbial cell factories 20100101

• Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus.

  PloS one 20100101

• Treatment of acute, non-traumatic pain using a combination of diclofenac-cholestyramine, uridine triphosphate, cytidine monophosphate, and hydroxycobalamin.

  Proceedings of the Western Pharmacology Society 20100101

• Analysis of residuals from enzyme kinetic and protein folding experiments in the presence of correlated experimental noise.

  Analytical biochemistry 20091201

• Cloning and characterization of cytidine monophosphate-3-deoxy-d-manno-octulosonate synthetase from Arabidopsis thaliana.

  Journal of bioscience and bioengineering 20091201

• Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.

  European journal of medicinal chemistry 20091101

• A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme.

  Journal of molecular biology 20091016

• Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes.

  The FEBS journal 20091001

• The flexibility of a distant loop modulates active site motion and product release in ribonuclease A.

  Biochemistry 20090804

• Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics.

  Pharmacogenetics and genomics 20090801

• Interaction of cytidine 5'-monophosphate with Au(111): an in situ infrared spectroscopic study.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20090713

• The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.

  Glycobiology 20090701

• Crystal structure of alpha/beta-galactoside alpha2,3-sialyltransferase from a luminous marine bacterium, Photobacterium phosphoreum.

  FEBS letters 20090618

• A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy.

  Journal of medicinal chemistry 20090423

• Synthesis and activity of modified cytidine 5'-monophosphate probes for T4 RNA ligase 1.

  Nucleosides, nucleotides & nucleic acids 20090401

• Simple sequence repeats in Haemophilus influenzae.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20090301

• The possible role of human milk nucleotides as sleep inducers.

  Nutritional neuroscience 20090201

• Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase.

  Journal of the American Chemical Society 20090114

• High level of sialate-O-acetyltransferase activity in lymphoblasts of childhood acute lymphoblastic leukaemia (ALL): enzyme characterization and correlation with disease status.

  Glycoconjugate journal 20090101

• Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.

  PloS one 20090101

• The relationship between spotted fever group Rickettsiae and ixodid ticks.

  Veterinary research 20090101

• Synthesis of sialoglycopolypeptide for potentially blocking influenza virus infection using a rat alpha2,6-sialyltransferase expressed in BmNPV bacmid-injected silkworm larvae.

  BMC biotechnology 20090101

• The role of UPF0157 in the folding of M. tuberculosis dephosphocoenzyme A kinase and the regulation of the latter by CTP.

  PloS one 20090101

• Molecular evolution of the hyperthermophilic archaea of the Pyrococcus genus: analysis of adaptation to different environmental conditions.

  BMC genomics 20090101

• A Comparative Study of Metabolic Network Topology between a Pathogenic and a Non-Pathogenic Bacterium for Potential Drug Target Identification.

  Summit on translational bioinformatics 20090101

• Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo.

  Research in veterinary science 20081201

• Mononuclear phagocytes in the blood of turtles characterized by ultrastructural and cytochemical analyses and by phagocytic activity.

  Micron (Oxford, England : 1993) 20081201

• Online immobilized metal affinity chromatography/mass spectrometric analysis of changes elicited by cCMP in the murine brain phosphoproteome.

  Rapid communications in mass spectrometry : RCM 20081201

• Potentially prebiotic synthesis of pyrimidine beta-D-ribonucleotides by photoanomerization/hydrolysis of alpha-D-cytidine-2'-phosphate.

  Chembiochem : a European journal of chemical biology 20081013

• Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics.

  Drug metabolism and disposition: the biological fate of chemicals 20080901

• The influence of proline isomerization and off-pathway intermediates on the folding mechanism of eukaryotic UMP/CMP Kinase.

  Journal of molecular biology 20080829

• Determination of nucleotides in infant formula by ion-exchange liquid chromatography.

  Journal of agricultural and food chemistry 20080827

• Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid.

  Carbohydrate research 20080811

• The Whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution.

  DNA research : an international journal for rapid publication of reports on genes and genomes 20080801

• Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells.

  Oncogene 20080703

• Induction of nucleoside phosphorylase in Enterobacter aerogenes and enzymatic synthesis of adenine arabinoside.

  Journal of Zhejiang University. Science. B 20080701

• Miscoding properties of 6alpha- and 6beta-diastereoisomers of the N(2)-(estradiol-6-yl)-2'-deoxyguanosine DNA adduct by Y-family human DNA polymerases.

  Biochemistry 20080624

• [Ultrastructural analysis of 5' nucleotides distribution in acute myeloid leukemia subtypes].

  Zhongguo shi yan xue ye xue za zhi 20080601

• The mildiomycin biosynthesis: initial steps for sequential generation of 5-hydroxymethylcytidine 5'-monophosphate and 5-hydroxymethylcytosine in Streptoverticillium rimofaciens ZJU5119.

  Chembiochem : a European journal of chemical biology 20080523

• Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv.

  Journal of molecular modeling 20080501

• DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells.

  Oncogene 20080417

• Cloning and expression of the sucrose phosphorylase gene from Leuconostoc mesenteroides in Escherichia coli.

  Biotechnology letters 20080401

• Human pancreatic ribonuclease presents higher endonucleolytic activity than ribonuclease A.

  Archives of biochemistry and biophysics 20080315

• Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins.

  Journal of biomedical science 20080301

• The value of oral cytarabine ocfosfate and etoposide in the treatment of refractory and elderly AML patients.

  International journal of hematology 20080301

• Effect of the nucleotides CMP and UMP on exhaustion in exercise rats.

  Journal of physiology and biochemistry 20080301

• Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15.

  The Journal of biological chemistry 20080208

• CMP substitutions preferentially inhibit polysialic acid synthesis.

  Glycobiology 20080201

• Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions.

  Neuroscience letters 20080124

• Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.

  The Journal of biological chemistry 20080118

• Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products.

  Biochemistry 20080108

• CMP-pseudaminic acid is a natural potent inhibitor of PseB, the first enzyme of the pseudaminic acid pathway in Campylobacter jejuni and Helicobacter pylori.

  ChemMedChem 20080101

• Crystal structure of Vibrionaceae Photobacterium sp. JT-ISH-224 alpha2,6-sialyltransferase in a ternary complex with donor product CMP and acceptor substrate lactose: catalytic mechanism and substrate recognition.

  Glycobiology 20080101

• Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.

  Autonomic & autacoid pharmacology 20080101

• Separation of cytidine 5'-triphosphate biosynthesized from cytidine 5'-monophosphate on ion-exchange resin and HPLC analysis of cytidine compounds.

  Applied biochemistry and biotechnology 20080101

• Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations.

  Blood cells, molecules & diseases 20080101

• Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains.

  BMC microbiology 20080101

• Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation.

  Breast cancer research : BCR 20080101

• Biomimetic aminoacylation of ribonucleotides and RNA with aminoacyl phosphate esters and lanthanum salts.

  Journal of the American Chemical Society 20071226

• Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system.

  European journal of pharmacology 20071222

• Direct measurement of a pK(a) near neutrality for the catalytic cytosine in the genomic HDV ribozyme using Raman crystallography.

  Journal of the American Chemical Society 20071031

• Purification, crystallization and preliminary crystallographic characterization of the alpha 2,6-sialyltransferase from Photobacterium sp. JT-ISH-224.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20070801

• Synthesis and biological activity of a gemcitabine phosphoramidate prodrug.

  Journal of medicinal chemistry 20070726

• Differences in glutamic acid and 5'-ribonucleotide contents between flesh and pulp of tomatoes and the relationship with umami taste.

  Journal of agricultural and food chemistry 20070711

• Conformation of 3'CMP bound to RNase A using TrNOESY.

  Archives of biochemistry and biophysics 20070701

• Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase.

  The FEBS journal 20070701

• Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.

  The FEBS journal 20070701

• Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation.

  American journal of hematology 20070501

• The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates.

  The FEBS journal 20070401

• [Study on CTP production from CMP by beer yeast cell immobilized in PVA].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20070301

• Two-step potentially prebiotic synthesis of alpha-d-cytidine-5'-phosphate from d-glyceraldehyde-3-phosphate.

  Journal of the American Chemical Society 20070110

• The study of helical distortions due to environmental changes: choice of parameters.

  Biophysical chemistry 20070101

• Phosphatidylinositol synthase of Tetrahymena: inositol isomers as substrates in phosphatidylinositol biosynthesis and headgroup exchange reactions.

  The Journal of eukaryotic microbiology 20070101

• Mass spectrometric identification of Rab23 phosphorylation as a response to challenge by cytidine 3',5'-cyclic monophosphate in mouse brain.

  Rapid communications in mass spectrometry : RCM 20070101

• Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system.

  Archives of physiology and biochemistry 20070101

• Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase.

  Nucleosides, nucleotides & nucleic acids 20070101

• Denoising inferred functional association networks obtained by gene fusion analysis.

  BMC genomics 20070101

• Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma.

  Journal of medicinal chemistry 20061228

• Crystal structures of Salmonella typhimurium biodegradative threonine deaminase and its complex with CMP provide structural insights into ligand-induced oligomerization and enzyme activation.

  The Journal of biological chemistry 20061222

• Interactions of 1,12-diamino-4,9-dioxadodecane (OSpm) and Cu(II) ions with pyrimidine and purine nucleotides: adenosine-5'-monophosphate (AMP) and cytidine-5'-monophosphate (CMP).

  Journal of inorganic biochemistry 20061101

• Complete crystallographic analysis of the dynamics of CCA sequence addition.

  Nature 20061026

• Label-free and reagentless aptamer-based sensors for small molecules.

  Journal of the American Chemical Society 20061025

• Base and phosphate electron detachment energies of deoxyribonucleotide anions.

  Journal of the American Chemical Society 20061018

• On-line enhancement technique for the analysis of nucleotides using capillary zone electrophoresis/mass spectrometry.

  Analytical chemistry 20060915

• Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction.

  Glycobiology 20060901

• RNA recognition and cleavage by the SARS coronavirus endoribonuclease.

  Journal of molecular biology 20060811

• Structure of Staphylococcus aureus cytidine monophosphate kinase in complex with cytidine 5'-monophosphate.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20060801

• Transcript-assisted transcriptional proofreading.

  Science (New York, N.Y.) 20060728

• Tapping the nucleotide pool of the host: novel nucleotide carrier proteins of Protochlamydia amoebophila.

  Molecular microbiology 20060601

• Orientation of ordered structures of cytosine and cytidine -monophosphate adsorbed at Au(110)/liquid interfaces.

  Physical review letters 20060303

• The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate.

  The FEBS journal 20060301

• Differential proteome analysis of tonsils from children with chronic tonsillitis or with hyperplasia reveals disease-associated protein expression differences.

  Analytical and bioanalytical chemistry 20060301

• Cytidine 5'-monophosphate (CMP)-induced structural changes in a multifunctional sialyltransferase from Pasteurella multocida.

  Biochemistry 20060221

• The role of the 3' terminus of the Sindbis virus genome in minus-strand initiation site selection.

  Virology 20060220

• Charge transfer complexes of adenosine-5'-monophosphate and cytidine-5'-monophosphate with water-soluble cobalt(II) Schiff base complexes in aqueous solution.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060101

• Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier.

  Glycobiology 20060101

• Metabolic engineering of microbes for oligosaccharide and polysaccharide synthesis.

  Microbial cell factories 20060101

• Combinatorial multinuclear NMR and X-ray diffraction studies of uranium(VI)-nucleotide complexes.

  Journal of the American Chemical Society 20051102

• Enzymatic synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid.

  Bioscience, biotechnology, and biochemistry 20051001

• [Determination of cytidine triphosphate and related compound triphos and related compounds in the liquid of enzymatical reaction by high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20050901

• Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia.

  Blood 20050415

• Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter.

  Blood 20050401

• ITC in the post-genomic era...? Priceless.

  Biophysical chemistry 20050401

• Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium.

  Molecular pharmacology 20050301

• Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.

  Journal of medicinal chemistry 20050224

• Development of a simple and efficient method for assaying cytidine monophosphate sialic acid synthetase activity using an enzymatic reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide converting system.

  Analytical biochemistry 20050201

• Investigation of multiple binding sites on ribonuclease A using nano-electrospray ionization mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• A comprehensive update of the sequence and structure classification of kinases.

  BMC structural biology 20050101

• Chemical and enzymatic synthesis of 4'-thio-beta-D-arabinofuranosylcytosine monophosphate and triphosphate.

  Nucleosides, nucleotides & nucleic acids 20050101

• IR and Raman study on the interactions of the 5'-GMP and 5'-CMP phosphate groups with Mg(II), Ca(II), Sr(II), Ba(II), Cr(III), Co(II), Cu(II), Zn(II), Cd(II), Al(III) and Ga(III).

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20041201

• Interferon-alpha-2b and oral cytarabine ocfosfate for newly diagnosed chronic myeloid leukaemia.

  Annals of oncology : official journal of the European Society for Medical Oncology 20041201

• Isothermal titration calorimetric study of RNase-A kinetics (cCMP --> 3'-CMP) involving end-product inhibition.

  Pharmaceutical research 20040901

• Substrate-induced conformational changes in human UMP/CMP kinase.

  The Journal of biological chemistry 20040806

• The development of a continuous isothermal titration calorimetric method for equilibrium studies.

  Analytical biochemistry 20040801

• Fulminant bronchiolitis obliterans organizing pneumonia following 2 d of treatment with hydroxyurea, interferon-alpha and oral cytarabine ocfosfate for chronic myelogenous leukemia.

  European journal of haematology 20040701

• Molecular basis of Japanese variants of pyrimidine 5'-nucleotidase deficiency.

  British journal of haematology 20040701

• Mononucleotide recognition by cyclic trinuclear palladium(II) complexes containing 4,7-phenanthroline N,N bridges.

  Dalton transactions (Cambridge, England : 2003) 20040521

• cis-acting elements at opposite ends of the Citrus tristeza virus genome differ in initiation and termination of subgenomic RNAs.

  Virology 20040425

• Inhibitory effect of pyrimidine and purine nucleotides on the multiplication of Babesia gibsoni: possible cause of low parasitemia and simultaneous reticulocytosis in canine babesiosis.

  The Journal of veterinary medical science 20040401

• Multilamellar liposomes formed by phosphatidyl nucleosides: an NMR-HR-MAS characterization.

  Langmuir : the ACS journal of surfaces and colloids 20040217

• Selective detection and identification of sugar nucleotides by CE-electrospray-MS and its application to bacterial metabolomics.

  Analytical chemistry 20040201

• [Binding of unnatural alpha,beta-oligocytidylates with DNA duplexes].

  Molekuliarnaia biologiia 20040101

• The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal.

  Biochemical and biophysical research communications 20031114

• Solution structure and function of an essential CMP kinase of Streptococcus pneumoniae.

  Protein science : a publication of the Protein Society 20031101

• The blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes: sequence analysis, organization, and initial characterization.

  Chembiochem : a European journal of chemical biology 20030905

• GTPase catalysis by Ras and other G-proteins: insights from Substrate Directed SuperImposition.

  Journal of molecular biology 20030829

• Quantitative determination of noncovalent binding interactions using automated nanoelectrospray mass spectrometry.

  Analytical chemistry 20030701

• Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli.

  Chembiochem : a European journal of chemical biology 20030509

• Reaction of human UMP-CMP kinase with natural and analog substrates.

  European journal of biochemistry 20030401

• Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases.

  Bioorganic & medicinal chemistry letters 20030120

• Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.

  Acta crystallographica. Section D, Biological crystallography 20030101

• A severe hepatic disorder with myelodysplastic syndrome, treated with cytarabine ocfosfate, in a dog.

  Australian veterinary journal 20030101

• Production of cytidine 5'-monophosphate N-acetylneuraminic acid using recombinant Escherichia coli as a biocatalyst.

  Biotechnology and bioengineering 20021205

• Spectrum of phenotypes and genotypes in Parkinson's disease.

  Journal of neurology 20021001

• Internal initiation sites of de novo RNA synthesis within the hepatitis C virus polypyrimidine tract.

  Biochemical and biophysical research communications 20020719

• Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase.

  Biochimica et biophysica acta 20020718

• The mechanism of phosphorylation of natural nucleosides and anti-HIV analogues by nucleoside diphosphate kinase is independent of their sugar substituents.

  Chembiochem : a European journal of chemical biology 20020702

• Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2.

  Japanese journal of cancer research : Gann 20020701

• Toward the design of ribonuclease (RNase) inhibitors: ion effects on the thermodynamics of binding of 2'-CMP to RNase A.

  The Journal of pharmacology and experimental therapeutics 20020601

• Toward RNase inhibitors: thermodynamics of 2'-CMP/RNase-A binding in multi-ion buffer.

  Biochemical pharmacology 20020601

• Measurement of genome wide DNA methylation by reversed-phase high-performance liquid chromatography.

  Methods (San Diego, Calif.) 20020601

• Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity.

  The Journal of biological chemistry 20020531

• Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis.

  European journal of biochemistry 20020501

• Results of a phase II trial of a combination of oral cytarabine ocfosfate (YNK01) and interferon alpha-2b for the treatment of chronic myelogenous leukemia patients in chronic phase.

  Leukemia 20020401

• Cellular and biochemical mechanisms of the resistance of human cancer cells to a new anticancer ribo-nucleoside, TAS-106.

  Japanese journal of cancer research : Gann 20020401

• Determination of RNase A/2'-cytidine monophosphate binding affinity and enthalpy by a global fit of thermal unfolding curves.

  Analytical biochemistry 20020315

• Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.

  Cancer research 20020315

• Efficient sialyltransferase inhibitors based on glycosides of N-acetylglucosamine.

  Journal of the American Chemical Society 20020227

• Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae.

  The Journal of biological chemistry 20020208

• Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.

  Journal of molecular biology 20020208

• Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme.

  Journal of molecular biology 20020201

• Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.

  Structure (London, England : 1993) 20020201

• Bone marrow cytogenetic complete remission achieved by interferon-alpha plus cytarabine ocfosfate therapy in a patient with chronic myelogenous leukemia during extramedullary blast crisis.

  International journal of hematology 20020201

• Fluorescence sensing of ionic analytes in water: from transition metal ions to vitamin B13.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20020104

• Reversible substrate-induced domain motions in ribonuclease A.

  Proteins 20020101

• Characterization of alpha(2-->6)-sialyltransferase reaction intermediates: use of alternative substrates to unmask kinetic isotope effects.

  Methods in enzymology 20020101

• Prediction and overview of the RpoN-regulon in closely related species of the Rhizobiales.

  Genome biology 20020101

• Core promoter for initiation of Cucumber mosaic virus subgenomic RNA4A.

  Molecular plant pathology 20020101

• Interferon alpha plus intermittent oral Ara-C ocfosfate (YNK-01) in chronic myeloid leukemia primarily resistant or with minimal cytogenetic response to interferon.

  Haematologica 20011201

• Continuous oral cytarabine ocfosfate with interferon-alpha-2b for patients with newly diagnosed chronic myeloid leukaemia: a pilot study.

  British journal of haematology 20011201

• Synthesis and nucleic acid-binding properties of water-soluble porphyrins appending platinum(II) complexes.

  Chemical & pharmaceutical bulletin 20011201

• Inhibition of CMP-sialic acid transport into Golgi vesicles by nucleoside monophosphates.

  Biochemistry 20011127

• Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region.

  Life sciences 20011005

• Chimpanzee models for human disease and immunobiology.

  Immunological reviews 20011001

• The structure of CMP:2-keto-3-deoxy-manno-octonic acid synthetase and of its complexes with substrates and substrate analogs.

  Journal of molecular biology 20010907

• Titanium(IV) targets phosphoesters on nucleotides: implications for the mechanism of action of the anticancer drug titanocene dichloride.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20010901

• Cytochemical analysis of acid phosphatase activity in the venom secretory cells of Bothrops jararaca.

  Tissue & cell 20010801

• Novel method for enzymatic synthesis of CMP-NeuAc.

  Bioscience, biotechnology, and biochemistry 20010801

• Allosteric binding of nucleoside triphosphates to RNA polymerase regulates transcription elongation.

  Cell 20010727

• Mechanistic studies on phosphopantothenoylcysteine decarboxylase.

  Journal of the American Chemical Society 20010704

• AraC-based pharmacotherapy of chronic myeloid leukaemia.

  Expert opinion on pharmacotherapy 20010701

• Dominant inheritance of sialuria, an inborn error of feedback inhibition.

  American journal of human genetics 20010601

• Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria.

  The Journal of biological chemistry 20010427

• A highly specific pathogen-responsive promoter element from the immediate-early activated CMPG1 gene in Petroselinum crispum.

  The Plant journal : for cell and molecular biology 20010401

• Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells.

  Glycoconjugate journal 20010301

• Van't Hoff and calorimetric enthalpies from isothermal titration calorimetry: are there significant discrepancies?

  Biochemistry 20010213

• Use of nucleotides in weanling rats with diarrhea induced by a lactose overload: effect on the evolution of diarrhea and weight and on the histopathology of intestine, liver and spleen.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010201

• Capillary electrophoretic study of carboplatin and analogues with nucleoside monophosphates, di- and trinucleotides.

  Journal of inorganic biochemistry 20010115

• A molecular dynamics study based post facto free energy analysis of the binding of bovine angiogenin with UMP and CMP ligands.

  Indian journal of biochemistry & biophysics 20010101

• CDP-choline, but not cytidine, protects hippocampal CA1 neurones in the gerbil following transient forebrain ischaemia.

  Folia neuropathologica 20010101

• Eutectic phases in ice facilitate nonenzymatic nucleic acid synthesis.

  Astrobiology 20010101

• [Late phase II study of YNK-01 (an oral prodrug of cytarabine) for hepatocellular carcinoma].

  Gan to kagaku ryoho. Cancer & chemotherapy 19981001

• Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxynonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase.

  The Journal of biological chemistry 19930205

• Antibody-nucleic acid complexes. Oligo(dG)n and -(dT)n specificities associated with anti-DNA antibodies from autoimmune MRL mice.

  Biochemistry 19891226

• Synthesis and cytostatic and antiviral activities of 1-beta-D-ribofuranosyl-5-alkylcytosine (5-alkylcytidine) cyclic 3',5'-monophosphates.

  Journal of medicinal chemistry 19890101

• Inhibition of herpes simplex virus DNA polymerase by purine ribonucleoside monophosphates.

  The Journal of biological chemistry 19860205

• Inhibition of phosphatidylinositol synthase and other membrane-associated enzymes by stereoisomers of hexachlorocyclohexane.

  The Journal of biological chemistry 19850310

• Membrane phospholipid metabolism in the isoproterenol-induced cardiomyopathy of the rat.

  Recent advances in studies on cardiac structure and metabolism 19750101