6326-79-0 | 6-Bromoisatin

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$13.00	$10.00
10g	98%	in stock	$16.00	$12.00
25g	98%	in stock	$35.00	$25.00
100g	98%	in stock	$123.00	$87.00

Description

• Catalog Number: AB45398
• Chemical Name: 6-Bromoisatin
• CAS Number: 6326-79-0
• Molecular Formula: C8H4BrNO2
• Molecular Weight: 226.0269
• MDL Number: MFCD01631138
• SMILES: Brc1ccc2c(c1)NC(=O)C2=O
• NSC Number: 30748

Computed Properties

• Complexity: 241
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.3

Upstream Synthesis Route

6-Bromoisatin, a versatile chemical compound, finds a crucial role in chemical synthesis due to its unique properties and reactivity. In the realm of organic chemistry, 6-Bromoisatin serves as a valuable building block in the synthesis of various biologically active compounds and pharmaceuticals. Its bromine substituent enables selective functionalization reactions, making it a useful intermediate in the preparation of complex molecules.One of the key applications of 6-Bromoisatin in chemical synthesis is its utilization as a key starting material for the synthesis of diverse heterocyclic compounds. By engaging in palladium-catalyzed cross-coupling reactions, 6-Bromoisatin can be transformed into various substituted indoles, which serve as essential structural motifs in many natural products and drug candidates. Additionally, the bromine atom in 6-Bromoisatin can participate in nucleophilic substitution reactions, facilitating the introduction of functional groups at specific positions in the molecule.Furthermore, 6-Bromoisatin's versatility extends to its use in the construction of complex alkaloid structures through efficient synthetic routes. By leveraging its reactivity and compatibility with various transformation methods, chemists can access novel molecular scaffolds with potential biological activity. Whether employed in the assembly of heterocyclic frameworks or the modification of existing structures, 6-Bromoisatin plays a vital role in advancing the field of synthetic organic chemistry.

Literature

• Marine compounds selectively induce apoptosis in female reproductive cancer cells but not in primary-derived human reproductive granulosa cells.

  Marine drugs 20120101

• Novel methodology for the extraction and identification of natural dyestuffs in historical textiles by HPLC-UV-Vis-ESI MS. Case study: chasubles from the Wawel Cathedral collection.

  Analytical and bioanalytical chemistry 20110301

• Bioactivity of the Murex Homeopathic Remedy and of Extracts from an Australian Muricid Mollusc against Human Cancer Cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• QSAR study of isatin analogues as in vitro anti-cancer agents.

  European journal of medicinal chemistry 20100301

• Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: a potential colorectal cancer chemopreventative.

  Cancer biology & therapy 20100301

• Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

  ChemMedChem 20091207

• Sex-specific Tyrian purple genesis: precursor and pigment distribution in the reproductive system of the marine mollusc, Dicathais orbita.

  Journal of chemical ecology 20080101

• In vitro cytotoxicity evaluation of some substituted isatin derivatives.

  Bioorganic & medicinal chemistry 20070115