648449-76-7 | AS-604850

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$9.00	$6.00
5mg	99%	in stock	$19.00	$13.00
10mg	99%	in stock	$28.00	$19.00
25mg	99%	in stock	$45.00	$31.00
50mg	99%	in stock	$73.00	$51.00

Description

• Catalog Number: AD16696
• Chemical Name: AS-604850
• CAS Number: 648449-76-7
• Molecular Formula: C11H5F2NO4S
• Molecular Weight: 285.22350639999996
• MDL Number: MFCD09265247
• SMILES: O=C1NC(=O)C(=Cc2ccc3c(c2)OC(O3)(F)F)S1

Computed Properties

• Complexity: 468
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 2.8

Literature

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration.

  The international journal of biochemistry & cell biology 20121101

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells.

  Journal of hepatology 20101101

• Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor.

  International immunopharmacology 20100901

• Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells.

  Blood 20060115

• Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

  Nature medicine 20050901

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419