65-86-1 | Orotic acid

Packsize	Purity	Availability	Price	Discounted Price
100g	98+%	in stock	$13.00	$9.00
500g	98+%	in stock	$57.00	$40.00

Description

• Catalog Number: AB46812
• Chemical Name: Orotic acid
• CAS Number: 65-86-1
• Molecular Formula: C5H4N2O4
• Molecular Weight: 156.0963
• MDL Number: MFCD00149398
• SMILES: O=c1[nH]c(=O)[nH]c(c1)C(=O)O

Computed Properties

• Complexity: 268
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1
• XLogP3: -1.4

Literature

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  Toxicological sciences : an official journal of the Society of Toxicology 20150401

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• Determination of 5-aminoimidazole-4-carboxamide in human plasma by ion-pair extraction and LC-MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070815

• Carbanions from decarboxylation of orotate analogs: stability and mechanistic implications.

  Bioorganic chemistry 20070801

• Production of uridine 5'-monophosphate by Corynebacterium ammoniagenes ATCC 6872 using a statistically improved biocatalytic process.

  Applied microbiology and biotechnology 20070801

• Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.

  The Journal of pharmacology and experimental therapeutics 20070801

• Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium.

  Microbiology (Reading, England) 20070801

• Structures of ligand-free and inhibitor complexes of dihydroorotase from Escherichia coli: implications for loop movement in inhibitor design.

  Journal of molecular biology 20070727

• Low citrulline may not be diagnostic of ornithine transcarbamylase deficiency: a case report.

  Journal of inherited metabolic disease 20070601

• mer-Diaquabis(1H-imidazole-kappaN3)[orotato(2-)]cobalt(II).

  Acta crystallographica. Section C, Crystal structure communications 20070601

• Lithium toxicity from an Internet dietary supplement.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20070601

• Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis.

  Biochemistry 20070515

• The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.

  FEMS microbiology letters 20070501

• Mechanism of flavin reduction in the class 1A dihydroorotate dehydrogenase from Lactococcus lactis.

  Biochemistry 20070403

• Comparative studies on pyrimidine metabolism in excised cotyledons of Pinus radiata during shoot formation in vitro.

  Journal of plant physiology 20070401

• Potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for differential diagnosis of nonalcoholic steatohepatitis and fatty liver in rats using magnetic resonance imaging.

  Investigative radiology 20070401

• Regulation of the pyrimidine biosynthetic pathway in a pyrD knockout mutant of Pseudomonas aeruginosa.

  Journal of basic microbiology 20070401

• Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase.

  FEMS microbiology letters 20070301

• Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20070301

• Citrin deficiency: a novel cause of failure to thrive that responds to a high-protein, low-carbohydrate diet.

  Pediatrics 20070301

• Japanese black cattle with orotic aciduria detected by gas-chromatography/mass-spectrometry.

  The Journal of veterinary medical science 20070301

• Two step derivatization for the analyses of organic, amino acids and glycines on filter paper plasma by GC-MS/SIM.

  Archives of pharmacal research 20070301

• Dicoumarol impairs mitochondrial electron transport and pyrimidine biosynthesis in human myeloid leukemia HL-60 cells.

  Biochemical pharmacology 20070201

• Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

  Journal of medicinal chemistry 20070125

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  Journal of proteome research 20070101

• The clinical application of metabolic therapy for cardiovascular disease.

  Heart, lung & circulation 20070101

• Swainsonine reduces 5-fluorouracil tolerance in the multistage resistance of colorectal cancer cell lines.

  Molecular cancer 20070101

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  Journal of the International Society of Sports Nutrition 20070101

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  Chemistry Central journal 20070101

• Classical genetics.

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  Voprosy pitaniia 20070101

• Improved protocols for functional analysis in the pathogenic fungus Aspergillus flavus.

  BMC microbiology 20070101

• The oncoprotein H-RasV12 increases mitochondrial metabolism.

  Molecular cancer 20070101

• Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases.

  Biochemistry 20061219

• New lanthanum (III) complex--synthesis, characterization, and cytotoxic activity.

  Archiv der Pharmazie 20061101

• catena-Poly[[[triaquacobalt(II)]-mu-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylato(2-)] 1.72-hydrate].

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• European Academy of Paediatrics, Barcelona, Spain, October 7-10, 2006. Abstracts.

  European journal of pediatrics 20061101

• Crystallization and preliminary X-ray diffraction analysis of Leishmania major dihydroorotate dehydrogenase.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20061001

• Effects of arginine treatment on nutrition, growth and urea cycle function in seven Japanese boys with late-onset ornithine transcarbamylase deficiency.

  European journal of pediatrics 20060901

• Endogenous ascorbic acid modulates meristem reactivation in white spruce somatic embryos and affects thymidine and uridine metabolism.

  Tree physiology 20060901

• Control of ribosome turnover during growth of the haloalkaliphilic archaeon Natronococcus occultus.

  Research in microbiology 20060901

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  Plant science : an international journal of experimental plant biology 20060901

• Thermodynamic analysis of catalysis by the dihydroorotases from hamster and Bacillus caldolyticus, as compared with the uncatalyzed reaction.

  Biochemistry 20060711

• Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase.

  Protein expression and purification 20060701

• Long-term correction of ammonia metabolism and prolonged survival in ornithine transcarbamylase-deficient mice following liver-directed treatment with adeno-associated viral vectors.

  Molecular therapy : the journal of the American Society of Gene Therapy 20060701

• Vector-related tumorigenesis not found in ornithine transcarbamylase-deficient mice.

  Molecular therapy : the journal of the American Society of Gene Therapy 20060701

• Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis.

  The Journal of biological chemistry 20060630

• 13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus.

  Biochemistry 20060613

• Pre-operative preparation for cardiac surgery utilising a combination of metabolic, physical and mental therapy.

  Heart, lung & circulation 20060601

• Micellar electrokinetic capillary chromatographic method for the quantitative analysis of uricosuric and antigout drugs in pharmaceutical preparations.

  Electrophoresis 20060601

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  Biochemistry 20060425

• PCR-mediated seamless gene deletion and marker recycling in Saccharomyces cerevisiae.

  Yeast (Chichester, England) 20060415

• Stability of large segmental duplications in the yeast genome.

  Genetics 20060401

• Accelerated decarboxylation of 1,3-dimethylorotic acid in ionic liquid.

  Bioorganic chemistry 20060401

• Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.

  Bioorganic & medicinal chemistry letters 20060315

• Electronic structure of orotic acid III geometric feature and thermal properties of some transition metal orotic acid complexes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060301

• Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms.

  Parasitology international 20060301

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  Clinical biochemistry 20060301

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  Electrophoresis 20060301

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  Journal of chromatography. A 20060224

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  Metabolism: clinical and experimental 20060201

• Influence of calcium and phosphorus, lactose, and salt-to-moisture ratio on Cheddar cheese quality: changes in residual sugars and water-soluble organic acids during ripening.

  Journal of dairy science 20060201

• Counter-selectable marker for bacterial-based interaction trap systems.

  BioTechniques 20060201

• An unusual clinical and biochemical presentation of ornithine transcarbamylase deficiency in a male patient.

  Journal of inherited metabolic disease 20060201

• An engineered nonsense URA3 allele provides a versatile system to detect the presence, absence and appearance of the [PSI+] prion in Saccharomyces cerevisiae.

  Yeast (Chichester, England) 20060130

• The diagnostic utility of a genetics evaluation in children with pervasive developmental disorders.

  Genetics in medicine : official journal of the American College of Medical Genetics 20060101

• Integration of genomic and metabonomic data in systems biology--are we 'there' yet?

  Current opinion in drug discovery & development 20060101

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  Alternative therapies in health and medicine 20060101

• Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.

  Arzneimittel-Forschung 20060101

• Pyrimidine base supplementation effects curdlan production in Agrobacterium sp. ATCC 31749.

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• PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats.

  Anticancer research 20060101

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  Nutrition journal 20060101

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  Microbial cell factories 20060101

• A fluoroorotic acid-resistant mutant of Arabidopsis defective in the uptake of uracil.

  Journal of experimental botany 20060101

• 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans.

  Mycologia 20060101

• Analysis of pyrimidine synthesis de novo intermediates in urine during crisis of a patient with ornithine transcarbamylase deficiency.

  Nucleosides, nucleotides & nucleic acids 20060101

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• The Elbs and Boyland-Sims peroxydisulfate oxidations.

  Beilstein journal of organic chemistry 20060101

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  Clinical biochemistry 20051101

• Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20051001

• Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway.

  American journal of physiology. Gastrointestinal and liver physiology 20050901

• A high-efficiency method to replace essential genes with mutant alleles in yeast.

  Yeast (Chichester, England) 20050730

• The influence of metals on the electronic system of biologically important ligands. Spectroscopic study of benzoates, salicylates, nicotinates and isoorotates. Review.

  Journal of inorganic biochemistry 20050701

• Inhibition of de novo pyrimidine synthesis in growing potato tubers leads to a compensatory stimulation of the pyrimidine salvage pathway and a subsequent increase in biosynthetic performance.

  The Plant cell 20050701

• Urinary uracil in female patients with ornithine transcarbamylase deficiency.

  Pediatrics international : official journal of the Japan Pediatric Society 20050601

• Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits.

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• Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells.

  Parasitology international 20050301

• Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid.

  Biochemical pharmacology 20050215

• 5-Fluoro-orotic acid induces chromosome alterations in Candida albicans.

  Yeast (Chichester, England) 20050115

• Regulation of pyrimidine biosynthesis in Acidovorax delafieldii.

  Journal of basic microbiology 20050101

• [Clinical value of the use of magnesium orotate in adolescents with syndrome of cardiac connective tissue dysplasia].

  Kardiologiia 20050101

• Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid.

  Nutrition (Burbank, Los Angeles County, Calif.) 20050101

• Dietary supplementation with orotate and uracil increases adaptive growth of jejunal mucosa after massive small bowel resection in rats.

  JPEN. Journal of parenteral and enteral nutrition 20050101

• Ornithine aminotransferase deficiency: diagnostic difficulties in neonatal presentation.

  Journal of inherited metabolic disease 20050101

• Synthesis and properties of PNA oligomers containing orotic acid derivatives.

  Nucleosides, nucleotides & nucleic acids 20050101

• Mechanism of the dihydroorotase reaction.

  Biochemistry 20041228

• The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20041201

• Alterations in pyrimidine nucleotide metabolism as an early signal during the execution of programmed cell death in tobacco BY-2 cells.

  Journal of experimental botany 20041201

• Analysis of pyrimidine synthesis 'de novo' intermediates in urine and dried urine filter- paper strips with HPLC-electrospray tandem mass spectrometry.

  Clinical chemistry 20041101

• mer-Diaquabis(1H-imidazole-kappaN3)(orotato-kappa2N3,O4nickel(II).

  Acta crystallographica. Section C, Crystal structure communications 20041101

• Comparison of ion-pair chromatography and capillary zone electrophoresis for the assay of organic acids as markers of abnormal metabolism.

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  Chemical & pharmaceutical bulletin 20041001

• Alleviation of fatty liver by alpha-linolenic acid.

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• Interstitial deletion of chromosome 2q32-34 associated with multiple congenital anomalies and a urea cycle defect (CPS I deficiency).

  American journal of medical genetics. Part A 20040730

• Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics.

  Journal of the American Chemical Society 20040609

• Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy.

  Biochemistry 20040601

• Improvement of culture conditions and evidence for nuclear transformation by homologous recombination in a red alga, Cyanidioschyzon merolae 10D.

  Plant & cell physiology 20040601

• A suspected case of ornithine transcarbamylase deficiency in a cat.

  The Journal of veterinary medical science 20040601

• Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age.

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  Brain research 20040515

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  Acta paediatrica (Oslo, Norway : 1992) 20040501

• An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.

  Physiological genomics 20040413

• Modest catalysis of the decarboxylation of orotate by hydrogen bonding: a theoretical model for orotidine- 5' -monophosphate decarboxylase.

  Bioorganic chemistry 20040401

• Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile.

  Molecular and biochemical parasitology 20040401

• Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.

  Protein science : a publication of the Protein Society 20040401

• pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.

  Eukaryotic cell 20040401

• Analytical derivatization-a tool for determination of orotic acid.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040125

• Alanine : glyoxylate aminotransferase of Saccharomyces cerevisiae-encoding gene AGX1 and metabolic significance.

  Yeast (Chichester, England) 20040115

• Regulation of pyrimidine nucleotide formation in Pseudomonas reptilivora.

  Letters in applied microbiology 20040101

• Determination of orotic acid, uric acid, and creatinine in milk by liquid chromatography.

  Journal of AOAC International 20040101

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  Biomeditsinskaia khimiia 20040101

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  JPEN. Journal of parenteral and enteral nutrition 20040101

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  Microbiology and immunology 20040101

• Magnesium orotate--experimental and clinical evidence.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 20040101

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  Carcinogenesis 20031201

• Experimental evidence for the existence of the passive antitumor defense system formed by the synergistic action of certain small substances of the circulatory system.

  Cancer biotherapy & radiopharmaceuticals 20031201

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  Magnetic resonance in medicine 20031101

• Cloning and disruption of the PpURA5 gene and construction of a set of integration vectors for the stable genetic modification of Pichia pastoris.

  Yeast (Chichester, England) 20031101

• Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.

  British journal of cancer 20031020

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  Clinica chimica acta; international journal of clinical chemistry 20030901

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• Concentration and purification of orotic acid directly from whey with an expanded bed adsorption system.

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• Quantification of non-protein nitrogen components of infant formulae and follow-up milks: comparison with cows' and human milk.

  The British journal of nutrition 20030701

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• Comprehensive study of the luminescent properties and lifetimes of Eu(3+) and Tb(3+) chelated with various ligands in aqueous solutions: influence of the synergic agent, the surfactant and the energy level of the ligand triplet.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030601

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  Biological & pharmaceutical bulletin 20030501

• Hexaaquanickel diorotate(1-) dihydrate at 150 K.

  Acta crystallographica. Section C, Crystal structure communications 20030401

• Determination of orotic acid in urine by capillary zone electrophoresis in tandem-coupled columns with diode array detection.

  Journal of chromatography. A 20030321

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  Clinical chemistry 20030301

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• Microarray analysis of orthologous genes: conservation of the translational machinery across species at the sequence and expression level.

  Genome biology 20030101

• Rapid determination of orotic acid in urine by a fast liquid chromatography/tandem mass spectrometric method.

  Rapid communications in mass spectrometry : RCM 20030101

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  Heart, lung & circulation 20030101

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  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021205

• N-acetylglutamate synthase deficiency and the treatment of hyperammonemic encephalopathy.

  Annals of neurology 20021201

• Control of pyrimidine formation in Pseudomonas putida ATCC 17536.

  Canadian journal of microbiology 20021201

• Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells.

  Mitochondrion 20021201

• Equilibrium of formation of the 6-carbanion of UMP, a potential intermediate in the action of OMP decarboxylase.

  Journal of the American Chemical Society 20021127

• Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

  The Journal of biological chemistry 20021101

• The dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers.

  Protein science : a publication of the Protein Society 20021101

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  Journal of paediatrics and child health 20021001

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  European journal of clinical nutrition 20021001

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  Mutation research 20020725

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• A new type of dihydroorotate dehydrogenase, type 1S, from the thermoacidophilic archaeon Sulfolobus solfataricus.

  Extremophiles : life under extreme conditions 20020601

• Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.

  Bioscience, biotechnology, and biochemistry 20020601

• Molecular identification of a renal urate anion exchanger that regulates blood urate levels.

  Nature 20020523

• Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.

  Journal of hepatology 20020501

• The interaction of 5-fluoroorotic acid with transition metals: synthesis and characterisation of Ni(II), Cu(II) and Zn(II) complexes.

  Journal of inorganic biochemistry 20020428

• Transfer RNA gene-targeted retrotransposition of Dictyostelium TRE5-A into a chromosomal UMP synthase gene trap.

  Journal of molecular biology 20020426

• Development of a CE method to analyze organic acids in dairy products: application to study the metabolism of heat-shocked spores.

  Journal of agricultural and food chemistry 20020327

• Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography.

  Biochemistry 20020326

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  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020301

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  Genes & development 20020215

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  Electrophoresis 20020201

• The oral anti-volatile sulphur compound effects of zinc salts and their stability constants.

  European journal of oral sciences 20020201

• Dietary orotic acid increases 1 ,2-diacylglycerol level and lowers superoxide dismutase activity in rat liver.

  Journal of nutritional science and vitaminology 20020201

• Fluorescence sensing of ionic analytes in water: from transition metal ions to vitamin B13.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20020104

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  Human gene therapy 20020101

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  Vestnik Rossiiskoi akademii meditsinskikh nauk 20020101

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• Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism.

  BMC pediatrics 20020101

• A nonradioactive high-performance liquid chromatographic microassay for uridine 5'-monophosphate synthase, orotate phosphoribosyltransferase, and orotidine 5'-monophosphate decarboxylase.

  Analytical biochemistry 20011215

• Theoretical studies of mechanisms and kinetic isotope effects on the decarboxylation of orotic acid and derivatives.

  Journal of the American Chemical Society 20011205

• Evolution: constantly avoiding mutation.

  Current biology : CB 20011113

• Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase.

  The Journal of pharmacology and experimental therapeutics 20011101

• Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration.

  Parasitology international 20011101

• Orotic acid added to casein, but not to egg protein, soy protein, or wheat gluten diets increases 1,2-diacylglycerol levels and lowers superoxide dismutase activities in rat liver.

  Bioscience, biotechnology, and biochemistry 20011001

• Specific inhibition of a family 1A dihydroorotate dehydrogenase by benzoate pyrimidine analogues.

  Journal of medicinal chemistry 20010830

• Pitfalls in the detection of heterozygosity by allopurinol in a variant form of ornithine carbamoyltransferase deficiency.

  Journal of inherited metabolic disease 20010801

• Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis.

  Archives of biochemistry and biophysics 20010715

• Simple gas chromatographic-mass spectrometric procedure for diagnosing pyrimidine degradation defects for prevention of severe anticancer side effects.

  Journal of chromatography. B, Biomedical sciences and applications 20010705

• Contribution of the bacterial endosymbiont to the biosynthesis of pyrimidine nucleotides in the deep-sea tube worm Riftia pachyptila.

  The Journal of biological chemistry 20010629

• Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.

  Biochemistry 20010619

• Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.

  Nature structural biology 20010601

• Intra-day variations in urinary pyrimidines in ornithine carbamoyltransferase deficiency and healthy individuals.

  Clinica chimica acta; international journal of clinical chemistry 20010601

• Capillary zone electrophoresis of orotic acid in urine with on-line isotachophoresis sample pretreatment and diode array detection.

  Journal of chromatography. A 20010504

• Rapid selection against truncation mutants in yeast reverse two-hybrid screens.

  BioTechniques 20010501

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  Journal of pediatric gastroenterology and nutrition 20010501

• Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies.

  Biochemistry 20010410

• Successful living-donor liver transplantation from an asymptomatic carrier mother in ornithine transcarbamylase deficiency.

  The Journal of pediatrics 20010301

• Large-scale production of the carbohydrate portion of the sialyl-Tn epitope, alpha-Neup5Ac-(2-->6)-D-GalpNAc, through bacterial coupling.

  Carbohydrate research 20010227

• Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.

  Biochemistry 20010220

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  Journal of inherited metabolic disease 20010201

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  The Journal of pediatrics 20010101

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  Voenno-meditsinskii zhurnal 20010101

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  Stomatologiia 20010101

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  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.

  Plant foods for human nutrition (Dordrecht, Netherlands) 20010101

• Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from Toxoplasma gondii.

  Biochemical pharmacology 19991101

• Effects of C-terminal deletion on the activity and thermostability of orotate phosphoribosyltransferase from Thermus thermophilus.

  Journal of biochemistry 19990101

• Magnesium orotate in myocardial and neuronal protection.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 19990101

• Metabolic supplementation with orotic acid and magnesium orotate.

  Cardiovascular drugs and therapy 19980901

• In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.

  Carcinogenesis 19940901

• Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii.

  Biochemical pharmacology 19940817

• Increase of serum very low density lipoproteins in rats after administration of alpha-hexachlorocyclohexane.

  Naunyn-Schmiedeberg's archives of pharmacology 19770601

• Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase.

  Biochimica et biophysica acta 19530101