656820-32-5 | Reversine

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$22.00	$15.00
5mg	98%	in stock	$26.00	$18.00
10mg	98%	in stock	$33.00	$23.00
50mg	98%	in stock	$75.00	$52.00
100mg	98%	in stock	$125.00	$87.00
250mg	98%	in stock	$209.00	$146.00
1g	98%	in stock	$565.00	$395.00

Description

• Catalog Number: AH14548
• Chemical Name: Reversine
• CAS Number: 656820-32-5
• Molecular Formula: C21H27N7O
• Molecular Weight: 393.4854
• MDL Number: MFCD07784513
• SMILES: C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2c1nc[nH]2

Computed Properties

• Complexity: 503
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 5
• XLogP3: 3.9

Literature

• Reversine promotes porcine muscle derived stem cells (PMDSCs) differentiation into female germ-like cells.

  Journal of cellular biochemistry 20121201

• The synthetic purine reversine selectively induces cell death of cancer cells.

  Journal of cellular biochemistry 20121001

• Preliminary evidence for the dedifferentiation of RAW 264.7 cells into mesenchymal progenitor-like cells by a purine analog.

  Tissue engineering. Part A 20120901

• [Research progress of cell dedifferentiation induced by reversine].

  Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20120901

• Reversine, a 2,6-disubstituted purine, as an anti-cancer agent in differentiated and undifferentiated thyroid cancer cells.

  Pharmaceutical research 20120701

• Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors.

  Bioorganic & medicinal chemistry letters 20120701

• Preferential killing of p53-deficient cancer cells by reversine.

  Cell cycle (Georgetown, Tex.) 20120601

• Small molecules that recapitulate the early steps of urodele amphibian limb regeneration and confer multipotency.

  ACS chemical biology 20120420

• Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.

  The Journal of biological chemistry 20120217

• Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy.

  Journal of biomedical science 20120101

• Reversin increase the plasticity of bone marrow-derived mesenchymal stem cell for generation of cardiomyocyte in vitro.

  Acta medica Indonesiana 20120101

• APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.

  Nature cell biology 20110918

• Novel chemically defined approach to produce multipotent cells from terminally differentiated tissue syncytia.

  ACS chemical biology 20110617

• Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.

  Nature communications 20110501

• Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.

  The EMBO journal 20110420

• Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells.

  Proteome science 20110101

• Proteomic definitions of mesenchymal stem cells.

  Stem cells international 20110101

• Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1.

  PloS one 20110101

• Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest.

  PloS one 20110101

• A simple guide screw method for intracranial xenograft studies in mice.

  Journal of visualized experiments : JoVE 20110101

• Reversine increases multipotent human mesenchymal cells differentiation potential.

  Journal of biological regulators and homeostatic agents 20110101

• Cell reprogramming: expectations and challenges for chemistry in stem cell biology and regenerative medicine.

  Cell death and differentiation 20100801

• Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.

  The Journal of cell biology 20100712

• Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells.

  Tissue engineering. Part A 20100401

• Beneficial effects of reversine on in vitro development of miniature pig somatic cell nuclear transfer embryos.

  The Journal of reproduction and development 20100401

• Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity.

  Nature medicine 20100401

• Ontology-based meta-analysis of global collections of high-throughput public data.

  PloS one 20100101

• Proteomic signature of reversine-treated murine fibroblasts by 2-D difference gel electrophoresis and MS: possible associations with cell signalling networks.

  Electrophoresis 20090601

• The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts.

  Cell death and differentiation 20090201

• Reversine increases the plasticity of lineage-committed cells toward neuroectodermal lineage.

  The Journal of biological chemistry 20090130

• Proteomic analysis of blastema formation in regenerating axolotl limbs.

  BMC biology 20090101

• Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells.

  Molecular cancer therapeutics 20080501

• Induction of growth arrest and polycomb gene expression by reversine allows C2C12 cells to be reprogrammed to various differentiated cell types.

  Proteomics 20071201

• The 2,6-disubstituted purine reversine induces growth arrest and polyploidy in human cancer cells.

  International journal of oncology 20071201

• Reversine stimulates adipocyte differentiation and downregulates Akt and p70(s6k) signaling pathways in 3T3-L1 cells.

  Biochemical and biophysical research communications 20070629

• Reversine inhibits spontaneous synaptic transmission in cultured rat hippocampal neurons.

  Cell biology international 20070601

• Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line.

  Aquatic toxicology (Amsterdam, Netherlands) 20070330

• Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle.

  Cell death and differentiation 20061201

• Small molecules driving myotube fission.

  Chemistry & biology 20051001

• 'Reversine' and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.

  Journal of medicinal chemistry 20050728

• Small molecules, big plans--can low-molecular-weight compounds control human regeneration?

  Angewandte Chemie (International ed. in English) 20040806

• Unraveling the molecular basis for regenerative cellular plasticity.

  PLoS biology 20040801

• Stem cells from differentiated cells.

  Molecular interventions 20040401

• Dedifferentiation? What's next?

  Molecular interventions 20040401

• Dedifferentiation of lineage-committed cells by a small molecule.

  Journal of the American Chemical Society 20040121