66309-69-1 | Cefotiam dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
25mg		in stock	$142.00	$99.00
1g	≥ 98% (Assay: Anhydrous basis)	in stock	$228.00	$160.00
5g	≥ 98% (Assay: Anhydrous basis)	in stock	$836.00	$586.00
25g	≥ 98% (Assay: Anhydrous basis)	in stock	$3,068.00	$2,148.00

Description

• Catalog Number: AI54625
• Chemical Name: Cefotiam dihydrochloride
• CAS Number: 66309-69-1
• Molecular Formula: C18H25Cl2N9O4S3
• Molecular Weight: 598.5500
• MDL Number: MFCD20488053
• SMILES: CN(CCn1nnnc1SCC1=C(C(=O)O)N2[C@H](SC1)[C@@H](C2=O)NC(=O)Cc1csc(n1)N)C.Cl.Cl

Computed Properties

• Complexity: 848
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 36
• Hydrogen Bond Acceptor Count: 13
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 10

Literature

• Molecular-weight-dependent, anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4.

  Drug metabolism and pharmacokinetics 20110101

• [Antimicrobial prophylaxis in radical prostatectomy : single dose versus 1-day treatment].

  Hinyokika kiyo. Acta urologica Japonica 20101001

• Detection of specific IgE antibodies to cefotiam-HSA conjugate by ELISA in a nurse with occupational anaphylaxis.

  Allergy 20100601

• Severe ulcerated 'bodybuilding acne' caused by anabolic steroid use and exacerbated by isotretinoin.

  International wound journal 20100601

• Multidrug-resistant Neisseria gonorrhoeae with reduced cefotaxime susceptibility is increasingly common in men who have sex with men, Amsterdam, the Netherlands.

  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20090917

• [Two cases of emphysematous pyelonephritis successfully treated by transurethral catheterization].

  Hinyokika kiyo. Acta urologica Japonica 20090501

• Systemic use of antibiotics does not prevent postoperative infection in elective colorectal surgery: a randomized controlled trial.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20090201

• Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.

  American journal of physiology. Renal physiology 20080701

• Penetration and exposure of cefotiam into the peritoneal fluid of abdominal surgery patients after intravenous administration.

  Journal of chemotherapy (Florence, Italy) 20080601

• Postmortem diagnosis of fatal anaphylaxis during intravenous administration of therapeutic and diagnostic agents: evaluation of clinical laboratory parameters and immunohistochemistry in three cases.

  Legal medicine (Tokyo, Japan) 20080501

• Quantitative prediction of oral absorption of PEPT1 substrates based on in vitro uptake into Caco-2 cells.

  International journal of pharmaceutics 20080416

• Development of breakpoints of cephems for intraabdominal infections based on pharmacokinetics and pharmacodynamics in the peritoneal fluid of patients.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080401

• Malakoplakia of the kidney.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20080201

• Prophylactic antibiotics given within 24 hours of surgery, compared with antibiotics given for 72 hours perioperatively, increased the rate of methicillin-resistant Staphylococcus aureus isolated from surgical site infections.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080201

• Spermatic cord abscess with concurrent prostatic abscess involving the seminal vesicle.

  Radiation medicine 20080201

• Randomized prospective comparison of fosfomycin and cefotiam for prevention of postoperative infection following urological surgery.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20071001

• [Fundamental study on the selection of antimicrobial prophylactic agents in abdominal surgery].

  The Japanese journal of antibiotics 20070801

• Cl- -dependent upregulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3.

  American journal of physiology. Renal physiology 20070701

• In vitro activity of cefotiam against oxacillin-resistant Staphylococcus epidermidis strains--reevaluation of beta-lactam antibiotics efficiency on MRSE.

  The Japanese journal of antibiotics 20070601

• Antibiotic prophylaxis in cerebrospinal fluid shunting: reassessment of Cefotiam penetration into human CSF.

  Zentralblatt fur Neurochirurgie 20070201

• Antibiotic prophylaxis in radical prostatectomy: 1-day versus 4-day treatments.

  International journal of urology : official journal of the Japanese Urological Association 20061201

• [Role of Ph-SA in enhancing bactericidal activity of beta-lactam antibiotics].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060101

• [Intraocular penetration of cefotiam hydrochloride, a kind of cephalosporin after filtration surgery in rabbit eyes].

  Nippon Ganka Gakkai zasshi 20050901

• The significance of the intraoperative repeated dosing of antimicrobials for preventing surgical wound infection in colorectal surgery.

  Surgery today 20050101

• Camel bite: an unusual type of head injury in an infant.

  Journal of pediatric surgery 20041001

• Flupenthixol and cefotiam: effects on vitamin A metabolism in rats.

  The British journal of nutrition 20041001

• [Efficacy of cefotiam hexetil in acute maxillary sinusitis, with a short five day vs ten day treatment].

  Medecine et maladies infectieuses 20041001

• Accidental intrathecal infusion of cefotiam: clinical presentation and management.

  European journal of clinical pharmacology 20040701

• Unexpected impaired consciousness in RA: a rare complication of SIADH induced by increased IL-6.

  Clinical and experimental rheumatology 20040101

• [Surveillance of susceptibility of clinical isolates to cefmetazole between 2000 and 2002].

  The Japanese journal of antibiotics 20031201

• Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2.

  Pharmaceutical research 20030901

• Protection with antibody to tumor necrosis factor differs with similarly lethal Escherichia coli versus Staphylococcus aureus pneumonia in rats.

  Anesthesiology 20030701

• [Antimicrobial activity of fosfomycin against beta-lactamase-producing methicillin-sensitive Staphylococcus aureus and methicillin-sensitive coagulase-negative staphylococci].

  The Japanese journal of antibiotics 20030401

• Successful treatment of a Salmonella aortic arch aneurysm.

  The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20030201

• [A questionnaire survey on the theory of postoperative infection prophylaxis in otorhinolaryngology].

  The Japanese journal of antibiotics 20030201

• [Prophylactic antibiotics in lumbar disc surgery: analysis of 1,030 procedures].

  Zentralblatt fur Neurochirurgie 20030101

• Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients.

  Arzneimittel-Forschung 20030101

• [A questionnaire survey on antimicrobial chemotherapy for acute peritonitis].

  The Japanese journal of antibiotics 20021201

• [A questionnaire survey on the theory of postoperative infection prophylaxis in urology].

  The Japanese journal of antibiotics 20021001

• Pharmacokinetics of antibiotic prophylaxis in major orthopedic surgery and blood-saving techniques.

  Orthopedics 20010701

• [Immunological properties of S-1090, cefmatilen hydrochloride hydrate].

  The Journal of toxicological sciences 20010501

• Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20010101

• Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses.

  Dermatology (Basel, Switzerland) 19960101

• [Potential nephrotoxicity of 2nd generation cephalosporins: cefuroxime versus cefotiam].

  Infection 19930101

• [Postmarketing survey on the clinical use of cefotiam].

  The Japanese journal of antibiotics 19830801

• Nephrotoxicity of cefotiam (CGP 14221/E) in rats and rabbits.

  Archives of toxicology 19810901

• Comparison of amino acids bathing the oxyntic gland area in the stimulation of gastric secretion.

  Gastroenterology 19760101