6640-24-0 | 1-(3-chlorophenyl)piperazine

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Description

• Catalog Number: AB44536
• Chemical Name: 1-(3-chlorophenyl)piperazine
• CAS Number: 6640-24-0
• Molecular Formula: C10H13ClN2
• Molecular Weight: 196.6766
• MDL Number: MFCD00040732
• SMILES: Clc1cccc(c1)N1CCNCC1
• NSC Number: 49307

Computed Properties

• Complexity: 157
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 1.7

Literature

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• Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies.

  The pharmacogenomics journal 20060101

• The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients.

  Behavioral and brain functions : BBF 20060101

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  Therapie 20060101

• Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.

  Journal of chromatography. A 20051209

• Estradiol supplementation modulates neuroendocrine response to M-chlorophenylpiperazine in menstrual status migrainosus triggered by oral contraception-free interval.

  Human reproduction (Oxford, England) 20051201

• Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice.

  Neuropharmacology 20051201

• Methylone and mCPP, two new drugs of abuse?

  Addiction biology 20051201

• Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine.

  Brain research 20051116

• m-Chlorophenylpiperazine exacerbates perception of salicylate-induced tinnitus in rats.

  The European journal of neuroscience 20051101

• Enhanced 5-HT2C receptor signaling is associated with haloperidol-induced 'early onset' vacuous chewing in rats: implications for antipsychotic drug therapy.

  Psychopharmacology 20051001

• Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter.

  Psychopharmacology 20051001

• Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat.

  Clinical and experimental pharmacology & physiology 20051001

• Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities.

  Brain research 20050928

• Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

  Anais da Academia Brasileira de Ciencias 20050901

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  Dialogues in clinical neuroscience 20050901

• Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder.

  Neuropsychiatric disease and treatment 20050901

• Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa.

  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20050805

• Serotonergic/glutamatergic interactions: potentiation of phencyclidine-induced stimulus control by citalopram.

  Pharmacology, biochemistry, and behavior 20050701

• Analgesic therapy in postherpetic neuralgia: a quantitative systematic review.

  PLoS medicine 20050701

• Responsiveness of 5-HT(1A) and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition.

  Journal of psychiatry & neuroscience : JPN 20050701

• Brain angiotensin and anxiety-related behavior: the transgenic rat TGR(ASrAOGEN)680.

  Brain research 20050607

• The use of sudden darkness in mice: a behavioural and pharmacological approach.

  Psychopharmacology 20050601

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  Current drug metabolism 20050601

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  Dialogues in clinical neuroscience 20050601

• Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on ethanol discrimination in the rat.

  Alcohol (Fayetteville, N.Y.) 20050601

• Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology.

  Biological psychiatry 20050515

• Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding.

  Journal of psychopharmacology (Oxford, England) 20050501

• Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6.

  Psychiatry research 20050430

• Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats.

  Brain research 20050408

• Measurement and characterization of energy intake in the mouse.

  Current protocols in pharmacology 20050401

• Agonist diversity in 5-HT(2C) receptor-mediated weight control in rats.

  Psychopharmacology 20050301

• m-CPP, a 5-HT2C receptor agonist that modifies the perfusion pressure of the hindquarter vascular bed of anesthetized rat.

  Pharmacology 20050201

• Anxiogenic treatments do not increase fear-potentiated startle in mice.

  Biological psychiatry 20050101

• Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs.

  Current topics in medicinal chemistry 20050101

• Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs.

  Neuroscience 20050101

• Pharmacological challenge with a serotonin 1D agonist in alcohol dependence.

  BMC psychiatry 20050101

• Effects of the 5-HT7 receptor antagonists SB-269970 and DR 4004 in autoshaping Pavlovian/instrumental learning task.

  Behavioural brain research 20041206

• Thermogenic effect of YM348, a novel 5-HT2C-receptor agonist, in rats.

  The Journal of pharmacy and pharmacology 20041201

• Anxiety-like state associates with taste to produce conditioned taste aversion.

  Biological psychiatry 20041201

• Behavioral effects of serotonin and serotonin agonists in two crayfish species, Procambarus clarkii and Orconectes rusticus.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20041201

• Behavioral phenotype of pre-proenkephalin-deficient mice on diverse congenic backgrounds.

  Psychopharmacology 20041101

• Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor.

  Pharmacopsychiatry 20041101

• Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice.

  Psychopharmacology 20041001

• Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041001

• Increased repetitive behaviours and prolactin responsivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders.

  The international journal of neuropsychopharmacology 20040901

• Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice.

  Progress in neuro-psychopharmacology & biological psychiatry 20040901

• A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits.

  Physiology & behavior 20040801

• Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats.

  Pharmacology, biochemistry, and behavior 20040801

• Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

  Naunyn-Schmiedeberg's archives of pharmacology 20040801

• Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile.

  Pharmacopsychiatry 20040701

• Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats.

  Pharmacology 20040601

• Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disorders.

  The Journal of clinical psychiatry 20040601

• New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.

  Journal of medicinal chemistry 20040506

• Indoline derivatives as 5-HT(2C) receptor agonists.

  Bioorganic & medicinal chemistry letters 20040503

• mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes.

  Neuropharmacology 20040401

• Relationship between anorexia and loss of serotonin uptake sites in brain of mice and rats receiving d-norfenfluramine or d-fenfluramine.

  Pharmacology, biochemistry, and behavior 20040301

• The application of the principles of clinical drug development to pharmacological challenge tests of the serotonergic system.

  Journal of psychopharmacology (Oxford, England) 20040301

• Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury.

  Pain 20040301

• m-Chlorophenylpiperazine (mCPP) modulates the discriminative stimulus effects of cocaine through actions at the 5-HT2C receptor.

  Behavioral neuroscience 20040201

• Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.

  European journal of pharmacology 20040126

• Neurobiological correlates of diagnosis and underlying traits in patients with borderline personality disorder compared with normal controls.

  Psychiatry research 20040101

• Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution.

  Molecular psychiatry 20040101

• Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist.

  European journal of pharmacology 20040101

• Bulimia nervosa with co-morbid avoidant personality disorder: behavioural characteristics and serotonergic function.

  Psychological medicine 20040101

• Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan.

  Neuropsychobiology 20040101

• Serotoninergics attenuate hyperlocomotor activity in rats. Potential new therapeutic strategy for hyperactivity.

  Neurotoxicity research 20040101

• Substitution profiles of N-methyl-D-aspartate antagonists in ethanol-discriminating inbred mice.

  Alcohol (Fayetteville, N.Y.) 20040101

• 5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy.

  Experimental neurology 20031201

• Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta.

  The European journal of neuroscience 20031101

• Implications of compulsive and impulsive traits for serotonin status in women with bulimia nervosa.

  Psychiatry research 20031015

• A PET study after treatment with an anxiety-provoking agent, m-chlorophenyl-piperazine, in conscious rhesus monkeys.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030901

• Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

  British journal of pharmacology 20030901

• Involvement of 5-HT(2) receptor in imipramine-induced hyperglycemia in mice.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030901

• Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats.

  Brain research 20030815

• Regulation of septo-hippocampal activity by 5-hydroxytryptamine(2C) receptors.

  The Journal of pharmacology and experimental therapeutics 20030801

• Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety.

  Life sciences 20030801

• MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys.

  Pharmacology, biochemistry, and behavior 20030801

• Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze.

  European journal of pharmacology 20030725

• Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

  Journal of medicinal chemistry 20030703

• Neuroendocrine response to the serotonin agonist M-chlorophenylpiperazine in women with menstrual status migrainosus.

  Neuroendocrinology 20030701

• m-CPP-induced self-grooming is mediated by 5-HT2C receptors.

  Behavioural brain research 20030616

• Effects of single and repeated electroconvulsive shock on the social and agonistic behaviour of resident rats.

  Neuropharmacology 20030601

• Screening for and validated quantification of amphetamines and of amphetamine- and piperazine-derived designer drugs in human blood plasma by gas chromatography/mass spectrometry.

  Journal of mass spectrometry : JMS 20030601

• Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia.

  Psychopharmacology 20030501

• Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test.

  Methods and findings in experimental and clinical pharmacology 20030501

• Effects of m-CPP in altering neuronal function: blocking depolarization in invertebrate motor and sensory neurons but exciting rat dorsal horn neurons.

  Brain research 20030418

• Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415

• Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.

  Cephalalgia : an international journal of headache 20030301

• Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity.

  Neuropharmacology 20030301

• The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study.

  Pharmacology, biochemistry, and behavior 20030301

• Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs.

  Biological psychiatry 20030215

• Differential regulation of somatodendritic and nerve terminal dopamine release by serotonergic innervation of substantia nigra.

  Journal of neurochemistry 20030201

• Effect of repeated administration of dexfenfluramine on feeding and brain Fos in mice.

  Physiology & behavior 20030201

• Central serotonergic effects of m-chlorophenylpiperazine (mCPP) among normal control adolescents.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101

• Pharmacological characterization of 5-HT(1B) receptor-mediated inhibition of local excitatory synaptic transmission in the CA1 region of rat hippocampus.

  British journal of pharmacology 20030101

• 5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function.

  The European journal of neuroscience 20030101

• 5-HT2C receptor agonists as potential drugs for the treatment of obesity.

  Current topics in medicinal chemistry 20030101

• Piperazine-derived designer drug 1-(3-chlorophenyl)piperazine (mCPP): GC-MS studies on its metabolism and its toxicological detection in rat urine including analytical differentiation from its precursor drugs trazodone and nefazodone.

  Journal of analytical toxicology 20030101

• Anxiolytic-like profile of propofol, a general anesthetic, in the plus-maze test in mice.

  Polish journal of pharmacology 20030101

• Neuroendocrine response to meta-chlorophenylpiperazine and ipsapirone in relation to anxiety and aggression.

  Psychiatry research 20021215

• Synthesis and pharmacological evaluation of new arylpiperazines. 3-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-quinazolidin-4-one - a dual serotonin 5-HT(1A)/5-HT(2A) receptor ligand with an anxiolytic-like activity.

  Bioorganic & medicinal chemistry 20021201

• Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021201

• Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies.

  Bipolar disorders 20021201

• Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brain.

  Neuropharmacology 20021201

• Involvement of 5-HT(2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism?

  Cellular and molecular neurobiology 20021201

• Neurogenetics of emotional reactivity to stress in animals.

  Dialogues in clinical neuroscience 20021201

• Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat.

  European journal of pharmacology 20021122

• 2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine].

  The Journal of pharmacology and experimental therapeutics 20021101

• 5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze.

  Psychopharmacology 20021101

• The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and men.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021101

• In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone.

  Xenobiotica; the fate of foreign compounds in biological systems 20021101

• Allelic variants of the serotonin(2C) receptor and neuroendocrinological responses to the serotonin(2C) receptor agonist m-chlorophenylpiperazine in healthy male volunteers.

  Pharmacopsychiatry 20021101

• Effects of GABA(A) compounds on mCPP drug discrimination in rats.

  Life sciences 20021018

• mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids.

  Pharmacology, biochemistry, and behavior 20021001

• p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro.

  Journal of neurochemistry 20020901

• Are there anxious genes?

  Dialogues in clinical neuroscience 20020901

• 5-HT(2C) receptor activation by m-chlorophenylpiperazine detected in humans with fMRI.

  Neuroreport 20020827

• Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients.

  Therapeutic drug monitoring 20020801

• Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats.

  International journal of impotence research 20020801

• The effects of serotonin agonists on the hypothalamic regulation of sexual receptivity in Syrian hamsters.

  Hormones and behavior 20020801

• Central administration of mCPP, a serotonin 5-HT(2B/2C) agonist, decreases water intake in rats.

  Pharmacology, biochemistry, and behavior 20020701

• Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression.

  Archives of general psychiatry 20020701

• Therapeutic and adverse actions of serotonin transporter substrates.

  Pharmacology & therapeutics 20020701

• Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms.

  Psychopharmacology 20020601

• Treatment of depression associated with the menstrual cycle: premenstrual dysphoria, postpartum depression, and the perimenopause.

  Dialogues in clinical neuroscience 20020601

• Gonadal steroids, brain, and behavior: role of context.

  Dialogues in clinical neuroscience 20020601

• Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents.

  Psychopharmacology 20020501

• Antinociceptive role of 5-HT1A receptors in rat spinal cord.

  British journal of anaesthesia 20020501

• Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramine.

  Synapse (New York, N.Y.) 20020401

• Human CYP3A4 and the metabolism of nefazodone and hydroxynefazodone by human liver microsomes and heterologously expressed enzymes.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020401

• Serotonin 2C receptor agonists and the behavioural satiety sequence in mice.

  Pharmacology, biochemistry, and behavior 20020401

• Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats.

  Pharmacology, biochemistry, and behavior 20020401

• Serotonin releasing agents. Neurochemical, therapeutic and adverse effects.

  Pharmacology, biochemistry, and behavior 20020401

• The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20020401

• Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat.

  Progress in neuro-psychopharmacology & biological psychiatry 20020401

• The atypical 5-HT2 receptor mediating tachycardia in pithed rats: pharmacological correlation with the 5-HT2A receptor subtype.

  British journal of pharmacology 20020301

• Saccadic peak velocity and EEG as end-points for a serotonergic challenge test.

  Human psychopharmacology 20020301

• Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis.

  Neuropharmacology 20020201

• Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administration.

  Psychopharmacology 20020201

• Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors.

  Bioorganic & medicinal chemistry letters 20020121

• Perturbations of plasma cortisol and DHEA-S following discontinuation of cocaine use in cocaine addicts.

  Psychoneuroendocrinology 20020101

• Psychomotor slowing, neuroendocrine responses, and behavioral changes after oral administration of meta-chlorophenylpiperazine in normal volunteers.

  Psychiatry research 20011231

• The subjective effects of MDMA and mCPP in moderate MDMA users.

  Drug and alcohol dependence 20011201

• The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia.

  Journal of clinical psychopharmacology 20011201

• The 5-HT2C/2B receptor agonist m-chlorophenylpiperazine (mCPP) inhibits 2-deoxy-D-glucose (2-DG)-induced hyperphagia in rats.

  Biological & pharmaceutical bulletin 20011201

• Effects of serotonin and serotonin analogs on posture and agonistic behavior in crayfish.

  Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 20011201

• Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.

  The international journal of neuropsychopharmacology 20011201

• m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors.

  Behavioural pharmacology 20011201

• Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man.

  Xenobiotica; the fate of foreign compounds in biological systems 20011101

• Altered responsiveness to 5-HT at the crayfish neuromuscular junction due to chronic p-CPA and m-CPP treatment.

  Brain research 20011019

• Association of serotonin and cortisol indices with childhood abuse in bulimia nervosa.

  Archives of general psychiatry 20010901

• Mapping of brain activation in response to pharmacological agents using fMRI in the rat.

  Magnetic resonance imaging 20010901

• Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells.

  Biochemical pharmacology 20010815

• Self-destructiveness and serotonin function in bulimia nervosa.

  Psychiatry research 20010805

• Pedophilia is accompanied by increased plasma concentrations of catecholamines, in particular epinephrine.

  Psychiatry research 20010805

• Tryptophan hydroxylase gene and major psychoses.

  Psychiatry research 20010805

• SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety.

  Neuropharmacology 20010801

• Altered response to meta-chlorophenylpiperazine in anorexia nervosa: support for a persistent alteration of serotonin activity after short-term weight restoration.

  The International journal of eating disorders 20010701

• Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat.

  Pharmacopsychiatry 20010701

• The serotonergic 5-HT(2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections.

  Experimental neurology 20010601

• A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation.

  Psychopharmacology 20010601

• 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010501

• Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors.

  Neuroscience research 20010501

• Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010501

• Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

  Psychological medicine 20010501

• Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients.

  Pharmacology & toxicology 20010501

• Effect of aerobic exercise on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine and to ipsapirone in untrained healthy subjects.

  Psychopharmacology 20010501

• Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats.

  Journal of psychopharmacology (Oxford, England) 20010301

• Neuroendocrine and behavioral responses to mCPP in Obsessive-Compulsive Disorder.

  Psychoneuroendocrinology 20010201

• Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons.

  Pharmacology, biochemistry, and behavior 20010201

• Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC).

  Cephalalgia : an international journal of headache 20010201

• Low versus standard dose mCPP challenge in obsessive-compulsive patients.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101

• Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101

• Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa.

  Psychological medicine 20010101

• Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement.

  Psychopharmacology 20010101

• m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors.

  Neuroscience 20010101

• Inhibition of K(+)-evoked release of rat striatal 5-hydroxytryptamine by an atypical antidepressant: trazodone.

  Neuropsychobiology 20010101

• Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.

  Pharmacology, biochemistry, and behavior 20010101

• Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.

  Circulation 20001205

• Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.

  European journal of pharmacology 20000707

• Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.

  Synapse (New York, N.Y.) 20000201

• Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions.

  Psychopharmacology 19991001

• Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions.

  Psychopharmacology 19990701

• High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.

  Journal of neurochemistry 19990501

• Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors.

  Naunyn-Schmiedeberg's archives of pharmacology 19990101

• Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.

  Drug metabolism and disposition: the biological fate of chemicals 19980601

• [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.

  Naunyn-Schmiedeberg's archives of pharmacology 19980101

• Effect of fenfluramine challenge on cocaine craving in addicted male users.

  The American journal on addictions 19980101

• The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.

  European journal of pharmacology 19970501

• SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

  Neuropharmacology 19970101

• Bupropion plasma levels and CYP2D6 phenotype.

  Therapeutic drug monitoring 19961001

• In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties.

  British journal of pharmacology 19960201

• Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist: effects on apparent agonist affinities.

  Biochemical pharmacology 19960112

• Post-synaptic 5-HT1A receptor involvement in yawning and penile erections induced by apomorphine, physostigmine and mCPP in rats.

  Psychopharmacology 19950801

• Trazodone treatment increases plasma prolactin concentrations in depressed patients.

  International clinical psychopharmacology 19950601

• Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission.

  European journal of pharmacology 19940811

• Central action of glaucine in rodents.

  Acta poloniae pharmaceutica 19940101

• Prolonged penile erections induced by hydroxyzine: possible mechanism of action.

  Neuropsychobiology 19940101

• d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.

  European journal of pharmacology 19930921

• Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

  The Journal of biological chemistry 19930825

• Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

  Molecular pharmacology 19930301

• Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

  Molecular pharmacology 19930301

• Trazodone induction of migraine headache through mCPP.

  The American journal of psychiatry 19920501

• Basic central pharmacological properties of thiophosphoric acid alkaloid derivatives from Chelidonium majus L.

  Polish journal of pharmacology and pharmacy 19920101

• Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

  Molecular pharmacology 19910801

• A pilot placebo-controlled study of chronic m-CPP administration in Alzheimer's disease.

  Biological psychiatry 19910715

• Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment.

  Archives of general psychiatry 19880201

• Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions.

  Journal of neural transmission 19870101

• Central antiserotonergic and antidopaminergic action of pirenperone, a putative 5-HT2 receptor antagonist.

  Polish journal of pharmacology and pharmacy 19850101

• 1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole.

  The Journal of pharmacy and pharmacology 19821001