666837-93-0 | Su9516

Packsize	Purity	Availability	Price	Discounted Price
1mg	99+%	in stock	$23.00	$17.00
5mg	99+%	in stock	$68.00	$48.00

Description

• Catalog Number: AB47055
• Chemical Name: Su9516
• CAS Number: 666837-93-0
• Molecular Formula: C13H11N3O2
• Molecular Weight: 241.2453
• MDL Number: MFCD17010284
• SMILES: COc1ccc2c(c1)/C(=C/c1c[nH]cn1)/C(=O)N2

Computed Properties

• Complexity: 369
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• Undefined Bond Stereocenter Count: 1
• XLogP3: 1

Literature

• Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations.

  Journal of medicinal chemistry 20060824

• The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism.

  Molecular pharmacology 20060801

• Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-dependent kinase 2 inhibitors.

  Bioorganic & medicinal chemistry letters 20030602

• SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells.

  Biochemical pharmacology 20021001

• A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells.

  Cancer research 20010815