69304-47-8 | Brivudine

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$6.00	$4.00
25mg	95%	in stock	$23.00	$17.00
250mg	95%	in stock	$98.00	$69.00
1g	95%	in stock	$235.00	$165.00
5g	95%	in stock	$729.00	$510.00

Description

• Catalog Number: AB71587
• Chemical Name: Brivudine
• CAS Number: 69304-47-8
• Molecular Formula: C11H13BrN2O5
• Molecular Weight: 333.1353
• MDL Number: MFCD00058585
• SMILES: Br/C=C/c1cn([C@H]2C[C@@H]([C@H](O2)CO)O)c(=O)[nH]c1=O

Computed Properties

• Complexity: 450
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: -0.4

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• Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors.

  Antiviral research 19900301

• Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.

  Journal of medicinal chemistry 19900201

• Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.

  Journal of medicinal chemistry 19890801

• (E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity.

  Biochemical pharmacology 19890615

• Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides.

  Journal of medicinal chemistry 19890201

• Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.

  Journal of medicinal chemistry 19880901

• Comparison of two bromovinyl nucleoside analogs, 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and E-5-(2-bromovinyl)-2'-deoxyuridine, with acyclovir in inhibition of Epstein-Barr virus replication.

  Antimicrobial agents and chemotherapy 19880701

• Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds.

  Journal of medicinal chemistry 19880101

• Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication.

  Antimicrobial agents and chemotherapy 19870901

• 2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.

  Journal of medicinal chemistry 19870701

• In vitro and in vivo antiviral activity of 2'-fluorinated arabinosides of 5-(2-haloalkyl)uracil.

  Antiviral research 19870601

• Selective inhibitory effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 2'-nor-cyclic GMP on adenovirus replication in vitro.

  Antimicrobial agents and chemotherapy 19870201

• Inhibiting effect of (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine on varicella-zoster virus replication in cell culture.

  Antimicrobial agents and chemotherapy 19870101

• Effect of antiviral agents on replication of herpes simplex virus type 1 in brain cultures.

  Antimicrobial agents and chemotherapy 19861201

• A novel selective broad-spectrum anti-DNA virus agent.

  Nature 19861001

• Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.

  Journal of medicinal chemistry 19860701

• Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines.

  Journal of medicinal chemistry 19860501

• Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.

  Journal of medicinal chemistry 19860401

• Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.

  Journal of medicinal chemistry 19860401

• Comparison of susceptibilities of varicella-zoster virus and herpes simplex viruses to nucleoside analogs.

  Antimicrobial agents and chemotherapy 19860301

• Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.

  Journal of medicinal chemistry 19860201

• Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2.

  Antimicrobial agents and chemotherapy 19860101

• 5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.

  Journal of medicinal chemistry 19851101

• Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2'-deoxyuridine, against herpes simplex virus.

  Antimicrobial agents and chemotherapy 19850801

• Comparative efficacy and selectivity of some nucleoside analogs against Epstein-Barr virus.

  Antimicrobial agents and chemotherapy 19850601

• Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.

  Journal of medicinal chemistry 19850601

• Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.

  Journal of medicinal chemistry 19850501

• Uridine 5'-diphosphate glucose analogues. Inhibitors of protein glycosylation that show antiviral activity.

  Journal of medicinal chemistry 19850101

• Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine 'acyclic' nucleoside analogues.

  Journal of medicinal chemistry 19841101

• Inhibition of human and woodchuck hepatitis virus DNA polymerase by the triphosphates of acyclovir, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and E-5-(2-bromovinyl)-2'-deoxyuridine.

  Antiviral research 19840801

• In vitro and in vivo antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and related compounds.

  Antiviral research 19840601

• 5-substituted deoxyuridines--structural requirements for antiviral activity against herpes simplex virus types 1 and 2 and possible biochemical basis for relative potency.

  Antiviral research 19840601

• Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.

  Journal of medicinal chemistry 19840301

• Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils.

  Journal of medicinal chemistry 19840101

• Oral antiviral drugs in experimental herpes simplex keratitis.

  Antimicrobial agents and chemotherapy 19831201

• Efficacy and selectivity of some nucleoside analogs as anti-human cytomegalovirus agents.

  Antimicrobial agents and chemotherapy 19831001

• Synergistic antiviral activity of acyclovir and interferon on human cytomegalovirus.

  Antimicrobial agents and chemotherapy 19830901

• Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines.

  Antiviral research 19830901

• Structural requirements of olefinic 5-substituted deoxyuridines for antiherpes activity.

  Journal of medicinal chemistry 19830901

• Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.

  Journal of medicinal chemistry 19830501

• Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].

  Journal of medicinal chemistry 19830401

• Synthesis and antiviral properties of some 2'-deoxy-5-(fluoroalkenyl)uridines.

  Journal of medicinal chemistry 19821101

• Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine against different herpes simplex virus strains in cell culture and against experimental herpes encephalitis in mice.

  Antiviral research 19821001

• Inhibitory effect of E-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on herpes simplex virus replication and DNA synthesis.

  Journal of virology 19820701

• Efficiency and selectivity of (E)-5-(2-bromovinyl)-2'-deoxyuridine and some other 5-substituted 2'-deoxypyrimidine nucleosides as anti-herpes agents.

  Antiviral research 19820501

• Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus.

  Antimicrobial agents and chemotherapy 19820201

• In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.

  Antimicrobial agents and chemotherapy 19820101

• Antiherpes activity of [E]-5-(1-propenyl)-2'-deoxyuridine and 5-(1-propenyl)-1-beta-D-arabinofuranosyluracil.

  Antiviral research 19811101

• Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases.

  Antimicrobial agents and chemotherapy 19810901

• Antiherpesviral and anticellular effects of 1-beta-D-arabinofuranosyl-E-5-(2-halogenovinyl) uracils.

  Antimicrobial agents and chemotherapy 19810701

• Selective inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine.

  Antimicrobial agents and chemotherapy 19810501

• Anti-herpes simplex virus and anti-human cell growth activity of E-5-propenyl-2'-deoxyuridine and the concept of selective protection in antivirus chemotherapy.

  Antimicrobial agents and chemotherapy 19801201

• (E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis.

  Antimicrobial agents and chemotherapy 19800101

• (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

  Proceedings of the National Academy of Sciences of the United States of America 19790601

• Letter: Panarteritis and regional enteritis.

  Gastroenterology 19760101