69308-37-8 | (R)-4-Amino-3-(4-chlorophenyl)butanoic acid

Packsize	Purity	Availability	Price	Discounted Price
25mg	>95.0%(T)(HPLC)	in stock	$26.00	$18.00
100mg	>95.0%(T)(HPLC)	in stock	$67.00	$47.00
1g	97%	in stock	$403.00	$282.00
5g	97%	in stock	$1,179.00	$825.00
10g	97%	in stock	$1,879.00	$1,316.00
25g	97%	in stock	$3,744.00	$2,621.00

Description

• Catalog Number: AB48599
• Chemical Name: (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
• CAS Number: 69308-37-8
• Molecular Formula: C10H12ClNO2
• Molecular Weight: 213.6608
• MDL Number: MFCD01321057
• SMILES: NC[C@@H](c1ccc(cc1)Cl)CC(=O)O

Computed Properties

• Complexity: 191
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: -1

Literature

• Discovery of a novel potent GABA(B) receptor agonist.

  Bioorganic & medicinal chemistry letters 20111101

• Efficacy and safety study of arbaclofen placarbil in patients with spasticity due to spinal cord injury.

  Spinal cord 20110901

• Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen.

  The Journal of pharmacology and experimental therapeutics 20090901

• QSAR and molecular modeling studies of baclofen analogues as GABA(B) agonists. Insights into the role of the aromatic moiety in GABA(B) binding and activation.

  Journal of medicinal chemistry 20010524

• Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.

  Nature 19970320