69659-80-9 | Sodium tanshinone IIA sulfonate

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$7.00	$5.00
10mg	98%	in stock	$13.00	$9.00
25mg	98%	in stock	$23.00	$17.00
50mg	98%	in stock	$38.00	$27.00
250mg	98%	in stock	$112.00	$79.00
1g	98%	in stock	$139.00	$97.00
5g	98%	in stock	$387.00	$271.00

Description

• Catalog Number: AH18466
• Chemical Name: Sodium tanshinone IIA sulfonate
• CAS Number: 69659-80-9
• Molecular Formula: C19H17NaO6S
• Molecular Weight: 396.3894
• MDL Number: MFCD09028094
• SMILES: O=C1c2c(ccc3c2CCCC3(C)C)c2c(C1=O)c(C)c(o2)S(=O)(=O)[O-].[Na+]

Computed Properties

• Complexity: 742
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1

Literature

• Sodium tanshinone IIA sulfonate prevents hypoxic trophoblast-induced endothelial cell dysfunction via targeting HMGB1 release.

  Journal of biochemical and molecular toxicology 20170701

• Tanshinone IIA protects rabbits against LPS-induced disseminated intravascular coagulation (DIC).

  Acta pharmacologica Sinica 20121001

• Anti-PRRSV effect and mechanism of sodium tanshinone IIA sulfonate in vitro.

  Journal of Asian natural products research 20120101

• A novel protocol for the preparation of sodium tanshinone sulphonates by direct ultrasound-assisted sulphonation of the crude extract of the roots of Salvia miltiorrhiza Bunge and following counter-current chromatography purification.

  Phytochemical analysis : PCA 20110101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Tanshinone IIA improves impaired nerve functions in experimental diabetic rats.

  Biochemical and biophysical research communications 20100813

• Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.

  American journal of respiratory cell and molecular biology 20091201

• Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets.

  American journal of physiology. Heart and circulatory physiology 20091001

• Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro.

  Experimental & molecular medicine 20090731

• Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090701

• Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.

  Xenobiotica; the fate of foreign compounds in biological systems 20090701

• Changes of c-fos and c-jun mRNA expression in angiotensin II-induced cardiomyocyte hypertrophy and effects of sodium tanshinone IIA sulfonate.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081001

• Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma/STAT1 pathways.

  Journal of clinical immunology 20080901

• Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism.

  Chinese journal of integrative medicine 20080901

• Effect of sodium tanshinone II A sulfonate on phosphorylation of extracellular signal-regulated kinase 1/2 in angiotensin II-induced hypertrophy of myocardial cells.

  Chinese journal of integrative medicine 20080601

• Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation.

  Journal of cardiovascular pharmacology 20080401

• [Changes of c-fos, c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin II and effects of tanshinone II A].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

• Determination of sodium tanshinone IIA sulfonate in plasma by liquid chromatography-electrospray ionisation-tandem mass spectrometry.

  Biomedical chromatography : BMC 20071101

• Pharmacological activity of cardiovascular agents from herbal medicine.

  Cardiovascular & hematological agents in medicinal chemistry 20071001

• Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice.

  Chemical & pharmaceutical bulletin 20070501

• A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1.

  Journal of immunology (Baltimore, Md. : 1950) 20070315

• Ion-pair reversed-phase HPLC: assay validation of sodium tanshinone IIA sulfonate in mouse plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202

• Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells.

  Biochemical pharmacology 20020815