700-06-1 | Indole-3-methanol

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$6.00	$4.00
1g	98%	in stock	$10.00	$7.00
5g	98%	in stock	$14.00	$10.00
25g	98%	in stock	$17.00	$12.00
500g	98%	in stock	$251.00	$176.00

Description

• Catalog Number: AB74767
• Chemical Name: Indole-3-methanol
• CAS Number: 700-06-1
• Molecular Formula: C9H9NO
• Molecular Weight: 147.1739
• MDL Number: MFCD00149341
• SMILES: OCc1c[nH]c2c1cccc2
• NSC Number: 525801

Computed Properties

• Complexity: 138
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 1.1

Literature

• Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway.

  Chemico-biological interactions 20180625

• Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay.

  Toxicology in vitro : an international journal published in association with BIBRA 20180201

• Enhancement of colon carcinogenesis by the combination of indole-3 carbinol and synbiotics in hemin-fed rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180201

• The promising effect of linagliptin and/or indole-3-carbinol on experimentally-induced polycystic ovarian syndrome.

  Chemico-biological interactions 20170801

• Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells.

  Archives of toxicology 20170501

• In vitro analysis of factors influencing CYP1A2 expression as potential determinants of interindividual variation.

  Pharmacology research & perspectives 20170401

• Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.

  Journal of hypertension 20161001

• Global gene expression and morphological alterations in the mammary gland after gestational exposure to bisphenol A, genistein and indole-3-carbinol in female Sprague-Dawley offspring.

  Toxicology and applied pharmacology 20160715

• The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: a review.

  Gene 20150510

• Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation.

  Chemico-biological interactions 20140325

• Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital.

  The Journal of toxicological sciences 20140201

• 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation.

  Toxicological sciences : an official journal of the Society of Toxicology 20140101

• Natural indoles, indole-3-carbinol and 3,3'-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression.

  Toxicology and applied pharmacology 20140101

• Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats.

  Reproductive toxicology (Elmsford, N.Y.) 20140101

• Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver.

  The Journal of toxicological sciences 20130101

• Screening of drugs to counteract human papillomavirus 16 E6 repression of E-cadherin expression.

  Investigational new drugs 20121201

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.

  Molecular and cellular endocrinology 20121105

• Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.

  Molecular carcinogenesis 20121101

• In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: involvement of Nrf2 and cell cycle/apoptosis signaling pathways.

  Molecular carcinogenesis 20121001

• Chronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent hypertension.

  The American journal of the medical sciences 20121001

• Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16(Ink4a)) in early-stage liver tumor-promotion facilitating liver cell regeneration in rats.

  Toxicology 20120928

• 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.

  Toxicology and applied pharmacology 20120915

• Antiangiogenic activity of indole-3-carbinol in endothelial cells stimulated with activated macrophages.

  Food chemistry 20120915

• In vitro suppression of growth of murine WEHI-3 leukemia cells and in vivo promotion of phagocytosis in a leukemia mice model by indole-3-carbinol.

  Journal of agricultural and food chemistry 20120808

• Modulation of carcinogen metabolizing cytochromes P450 in rat liver and kidney by cabbage and sauerkraut juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate.

  Phytotherapy research : PTR 20120801

• Modulation of CYP1A1, CYP1A2 and CYP1B1 expression by cabbage juices and indoles in human breast cell lines.

  Nutrition and cancer 20120801

• Diindolilmethane (DIM) selectively inhibits cancer stem cells.

  Biochemical and biophysical research communications 20120720

• [EGFR-dependent impact of indol-3-carbinol on radiosensitivity of lung cancer cells].

  Zhongguo fei ai za zhi = Chinese journal of lung cancer 20120720

• Emerging roles for modulation of microRNA signatures in cancer chemoprevention.

  Current cancer drug targets 20120701

• The cruciferous phytoalexins rapalexin A, brussalexin A and erucalexin: chemistry and metabolism in Leptosphaeria maculans.

  Bioorganic & medicinal chemistry 20120701

• Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices.

  Clinical and experimental pharmacology & physiology 20120701

• Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage.

  Toxicologic pathology 20120601

• Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3' diindolylmethane (DIM).

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512

• B-DIM impairs radiation-induced survival pathways independently of androgen receptor expression and augments radiation efficacy in prostate cancer.

  Cancer letters 20120501

• 3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest.

  Oncology reports 20120501

• The roles of different porcine cytochrome P450 enzymes and cytochrome b5A in skatole metabolism.

  Animal : an international journal of animal bioscience 20120501

• Effect of the pasteurization process on the contents of ascorbigen, indole-3-carbinol, indole-3-acetonitrile, and 3,3'-diindolylmethane in fermented cabbage.

  Journal of agricultural and food chemistry 20120411

• Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.

  Drug metabolism and disposition: the biological fate of chemicals 20120401

• Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals.

  Molecular carcinogenesis 20120301

• Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy.

  Journal of the American Society of Nephrology : JASN 20120301

• Synthesis and evaluation of the cytotoxicities of tetraindoles: observation that the 5-hydroxy tetraindole (SK228) induces G₂ arrest and apoptosis in human breast cancer cells.

  Journal of medicinal chemistry 20120223

• The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-κB, MAPK, and p53 signaling.

  Chemico-biological interactions 20120205

• Direct interactions between intestinal immune cells and the diet.

  Cell cycle (Georgetown, Tex.) 20120201

• Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment.

  British journal of cancer 20120117

• The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120101

• Imatinib ameliorates renal morphological changes in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.

  American journal of physiology. Renal physiology 20120101

• Tumor angiogenesis as a target for dietary cancer prevention.

  Journal of oncology 20120101

• The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1.

  Journal of biomedicine & biotechnology 20120101

• The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes.

  Journal of oncology 20120101

• Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis.

  Pulmonary medicine 20120101

• Novel targets for detection of cancer and their modulation by chemopreventive natural compounds.

  Frontiers in bioscience (Elite edition) 20120101

• Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).

  BMC medicine 20120101

• Ecologically appropriate xenobiotics induce cytochrome P450s in Apis mellifera.

  PloS one 20120101

• Marine compounds selectively induce apoptosis in female reproductive cancer cells but not in primary-derived human reproductive granulosa cells.

  Marine drugs 20120101

• Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells.

  PloS one 20120101

• 3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.

  PloS one 20120101

• Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM.

  PloS one 20120101

• Gene expression signature of DMBA-induced hamster buccal pouch carcinomas: modulation by chlorophyllin and ellagic acid.

  PloS one 20120101

• The safety of cruciferous plants in humans: a systematic review.

  Journal of biomedicine & biotechnology 20120101

• 3,3'Diindolylmethane suppresses vascular smooth muscle cell phenotypic modulation and inhibits neointima formation after carotid injury.

  PloS one 20120101

• Cigarette smoke exposure-associated alterations to non-coding RNA.

  Frontiers in genetics 20120101

• 3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.

  PloS one 20120101

• Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.

  PloS one 20120101

• AHR and the Transcriptional Regulation of Type-17/22 ILC.

  Frontiers in immunology 20120101

• Isolated Lymphoid Follicles are Dynamic Reservoirs for the Induction of Intestinal IgA.

  Frontiers in immunology 20120101

• Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury.

  Frontiers in physiology 20120101

• Current knowledge on pancreatic cancer.

  Frontiers in oncology 20120101

• Role of the Aryl Hydrocarbon Receptor in Controlling Maintenance and Functional Programs of RORγt(+) Innate Lymphoid Cells and Intraepithelial Lymphocytes.

  Frontiers in immunology 20120101

• Induction of endoplasmic reticulum stress response by the indole-3-carbinol cyclic tetrameric derivative CTet in human breast cancer cell lines.

  PloS one 20120101

• Effects of indole-3-carbinol and phenethyl isothiocyanate on bile and pancreatic juice excretion in rats.

  The journal of medical investigation : JMI 20120101

• Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo.

  PloS one 20120101

• Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway.

  Medical oncology (Northwood, London, England) 20111201

• Cancer chemoprevention by targeting the epigenome.

  Current drug targets 20111201

• Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes.

  International journal of obesity (2005) 20111201

• Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis.

  Cancer letters 20111201

• Interaction of cruciferous phytoanticipins with plant fungal pathogens: indole glucosinolates are not metabolized but the corresponding desulfo-derivatives and nitriles are.

  Phytochemistry 20111201

• Dietary ligands of the aryl hydrocarbon receptor induce anti-inflammatory and immunoregulatory effects on murine dendritic cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20111201

• Transient renin-angiotensin system stimulation in an early stage of life causes sustained hypertension in rats.

  Journal of hypertension 20111201

• Indole-3-carbinol and ultraviolet B induce apoptosis of human melanoma cells via down-regulation of MITF.

  Die Pharmazie 20111201

• Indole-3-carbinol enhances the resolution of rat liver fibrosis and stimulates hepatic stellate cell apoptosis by blocking the inhibitor of κB kinase α/inhibitor of κB-α/nuclear factor-κB pathway.

  The Journal of pharmacology and experimental therapeutics 20111101

• Angiotensin II-dependent hypertension causes reversible changes in the platelet proteome.

  Journal of hypertension 20111101

• Indole-3-carbinol inhibits telomerase activity and gene expression in prostate cancer cell lines.

  Anticancer research 20111101

• 3,3'-Diindolylmethane induces immunotoxicity via splenocyte apoptosis in neonatal mice.

  Toxicology letters 20111010

• Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cells.

  Archives of toxicology 20111001

• Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrative nucleoside transporter 1.

  Anticancer research 20111001

• Induction of cancer cell death by isoflavone: the role of multiple signaling pathways.

  Nutrients 20111001

• Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells.

  The Prostate 20110915

• Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats.

  Archives of toxicology 20110901

• Effectiveness of cidofovir intralesional treatment in recurrent respiratory papillomatosis.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20110901

• Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C?

  Oncology reports 20110901

• Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.

  Carcinogenesis 20110901

• Adjuvant therapy for laryngeal papillomatosis.

  Acta dermatovenerologica Alpina, Pannonica, et Adriatica 20110901

• LC-MS/MS quantification of sulforaphane and indole-3-carbinol metabolites in human plasma and urine after dietary intake of selenium-fortified broccoli.

  Journal of agricultural and food chemistry 20110810

• 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts.

  Free radical research 20110801

• Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.

  Journal of hypertension 20110801

• [Therapeutic effect of indole-3-carbinol on pig serum-induced hepatic fibrosis in rats].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110801

• Dimer radical cations of indole and indole-3-carbinol: localized and delocalized radical cations of diindolylmethane.

  The journal of physical chemistry. A 20110707

• Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.

  Biopharmaceutics & drug disposition 20110701

• MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease.

  Immune network 20110601

• Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine.

  Toxicology 20110510

• RuCl₃·3H₂O catalyzed reactions: facile synthesis of bis(indolyl)methanes under mild conditions.

  Molecules (Basel, Switzerland) 20110509

• Direct renin inhibition with aliskiren normalizes blood pressure in Cyp1a1-Ren2 transgenic rats with inducible angiotensin ii-dependent malignant hypertension.

  The American journal of the medical sciences 20110501

• Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice.

  Carcinogenesis 20110401

• Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice.

  Nutrition (Burbank, Los Angeles County, Calif.) 20110401

• Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate.

  The British journal of nutrition 20110301

• Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro.

  Toxicological sciences : an official journal of the Society of Toxicology 20110301

• Treatment of recurrent respiratory papillomatosis lung involvement by cidofovir infusion.

  Scandinavian journal of infectious diseases 20110201

• Enhancement of renin and prorenin receptor in collecting duct of Cyp1a1-Ren2 rats may contribute to development and progression of malignant hypertension.

  American journal of physiology. Renal physiology 20110201

• 3,3'-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model.

  Molecular carcinogenesis 20110201

• Indole-3-carbinol inhibits hepatic stellate cells proliferation by blocking NADPH oxidase/reactive oxygen species/p38 MAPK pathway.

  European journal of pharmacology 20110115

• Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK1/2.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.

  The Journal of physiology 20110101

• Bioactive food components and cancer-specific metabonomic profiles.

  Journal of biomedicine & biotechnology 20110101

• Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells.

  Journal of Cancer 20110101

• Defined plant extracts can protect human cells against combined xenobiotic effects.

  Journal of occupational medicine and toxicology (London, England) 20110101

• Estrogen induced metastatic modulators MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in thyroid cancer.

  PloS one 20110101

• Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner.

  Nutrition journal 20110101

• The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines.

  Breast cancer research : BCR 20110101

• Therapeutic Implications of Targeting AKT Signaling in Melanoma.

  Enzyme research 20110101

• Medical interventions for high grade vulval intraepithelial neoplasia.

  The Cochrane database of systematic reviews 20110101

• Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt.

  PloS one 20110101

• Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells.

  PloS one 20110101

• Indole-3-carbinol inhibits prostate cancer cell migration via degradation of beta-catenin.

  Oncology research 20110101

• How to reduce your cancer risk: mechanisms and myths.

  International journal of general medicine 20110101

• Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity.

  BMC cancer 20110101

• Oral carcinogenesis and oral cancer chemoprevention: a review.

  Pathology research international 20110101

• Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.

  PloS one 20110101

• Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic.

  Mutation research 20110101

• Adipocyte-derived factor as a modulator of oxidative estrogen metabolism: implications for obesity and estrogen-dependent breast cancer.

  In vivo (Athens, Greece) 20110101

• Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells.

  Molecular cancer 20110101

• Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice.

  Bioscience, biotechnology, and biochemistry 20110101

• Inhibition of fatty acid synthase and Sp1 expression by 3,3'-diindolylmethane in human breast cancer cells.

  Nutrition and cancer 20110101

• Understanding carcinogenesis for fighting oral cancer.

  Journal of oncology 20110101

• Indole-3-carbinol generates reactive oxygen species and induces apoptosis.

  Biological & pharmaceutical bulletin 20110101

• Nigerian foodstuffs with prostate cancer chemopreventive polyphenols.

  Infectious agents and cancer 20110101

• Selenium and lung cancer: a systematic review and meta analysis.

  PloS one 20110101

• The role of tobacco-derived carcinogens in pancreas cancer.

  ISRN oncology 20110101

• Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal Activity.

  Molecular biology international 20110101

• Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infection.

  International journal of biological sciences 20110101

• Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats.

  The Journal of toxicological sciences 20110101

• Effect of Turkish propolis extracts on proteome of prostate cancer cell line.

  Proteome science 20110101

• Development of derivatives of 3, 3'-diindolylmethane as potent Leishmania donovani bi-subunit topoisomerase IB poisons.

  PloS one 20110101

• Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

  Clinical epigenetics 20110101

• [The results of adjuvant therapy of juvenile recurring respiratory papillomatosis with the use of indole-3-carbinol].

  Vestnik otorinolaringologii 20110101

• THP-1 Macrophages and SGBS Adipocytes - A New Human in vitro Model System of Inflamed Adipose Tissue.

  Frontiers in endocrinology 20110101

• Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices.

  Clinical and experimental pharmacology & physiology 20101201

• Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol.

  Anticancer research 20101201

• Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.

  The American journal of the medical sciences 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro.

  Oral oncology 20101001

• Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.

  Carcinogenesis 20100901

• Inhibition of cancer cell invasion and metastasis by genistein.

  Cancer metastasis reviews 20100901

• Effects of lycopene, indole-3-carbinol, and luteolin on nitric oxide production and iNOS expression are organ-specific in rats.

  Arhiv za higijenu rada i toksikologiju 20100901

• 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.

  Chemico-biological interactions 20100805

• Effects of combined treatment with resveratrol and indole-3-carbinol.

  Bulletin of experimental biology and medicine 20100801

• Effect of 4-methoxyindole-3-carbinol on the proliferation of colon cancer cells in vitro, when treated alone or in combination with indole-3-carbinol.

  Journal of agricultural and food chemistry 20100728

• Radicals and radical ions derived from indole, indole-3-carbinol and diindolylmethane.

  The journal of physical chemistry. A 20100701

• 3,3'-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators.

  Molecular carcinogenesis 20100701

• A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation.

  Cancer prevention research (Philadelphia, Pa.) 20100701

• Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.

  Cancer research 20100615

• Automated generation and reactions of 3-hydroxymethylindoles in continuous-flow microreactors.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20100611

• Synthesis and biological evaluation of a gamma-cyclodextrin-based formulation of the anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b':7,8-b'':10,11-b''']tetraindole (CTet).

  Molecules (Basel, Switzerland) 20100604

• The renin-angiotensin system as a primary cause of polyarteritis nodosa in rats.

  Journal of cellular and molecular medicine 20100601

• Diet, microRNAs and prostate cancer.

  Pharmaceutical research 20100601

• Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy.

  Current drug targets 20100601

• Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research.

  Pharmaceutical research 20100601

• Transient induction of ANG II-dependent malignant hypertension causes sustained elevation of blood pressure and augmentation of the pressor response to ANG II in CYP1A1-REN2 transgenic rats.

  The American journal of the medical sciences 20100601

• Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis.

  Recent patents on food, nutrition & agriculture 20100601

• Cancer prevention with natural compounds.

  Seminars in oncology 20100601

• Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys.

  Cancer chemotherapy and pharmacology 20100501

• The potential efficacy of 3,3'-diindolylmethane in prevention of prostate cancer development.

  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20100501

• Pharmacological exploitation of indole-3-carbinol to develop potent antitumor agents.

  Mini reviews in medicinal chemistry 20100501

• The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker.

  International journal of andrology 20100401

• Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.

  Molecular biology of the cell 20100401

• AT1 receptor blockade prevents the increase in blood pressure and the augmentation of intrarenal ANG II levels in hypertensive Cyp1a1-Ren2 transgenic rats fed with a high-salt diet.

  The American journal of the medical sciences 20100401

• Dioxin-induced changes in epididymal sperm count and spermatogenesis.

  Environmental health perspectives 20100401

• Inappropriately high circulating and intrarenal angiotensin II levels during dietary salt loading exacerbate hypertension in Cyp1a1-Ren-2 transgenic rats.

  Journal of hypertension 20100301

• Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100301

• Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture.

  Experimental dermatology 20100201

• Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice.

  Carcinogenesis 20100201

• Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol.

  Carcinogenesis 20100201

• The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100101

• Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs.

  Cancer prevention research (Philadelphia, Pa.) 20100101

• Indole-3-carbinol inhibits nasopharyngeal carcinoma.

  International journal of toxicology 20100101

• Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages.

  Mediators of inflammation 20100101

• Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study.

  BMC cancer 20100101

• Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors.

  Molecular cancer 20100101

• Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study.

  Therapeutics and clinical risk management 20100101

• Diindolylmethane (DIM) spontaneously forms from indole-3-carbinol (I3C) during cell culture experiments.

  In vivo (Athens, Greece) 20100101

• Redox regulation in cancer: a double-edged sword with therapeutic potential.

  Oxidative medicine and cellular longevity 20100101

• Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer.

  Oxidative medicine and cellular longevity 20100101

• 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.

  BMC cancer 20100101

• Antimutagenicity and antiproliferative studies of lipidic extracts from white shrimp (Litopenaeus vannamei).

  Marine drugs 20100101

• Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking hormonal contraceptives or supplements: a randomized controlled trial.

  Breast cancer : basic and clinical research 20100101

• [Approaches to raising efficacy of treatment of patients with chronic prostatitis associated with intracellular infections].

  Urologiia (Moscow, Russia : 1999) 20100101

• Minireview: modulation of hormone receptor signaling by dietary anticancer indoles.

  Molecular endocrinology (Baltimore, Md.) 20091201

• Cellular signaling perturbation by natural products.

  Cellular signalling 20091101

• Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics.

  Cancer treatment reviews 20091101

• Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma.

  Molecular pharmacology 20091101

• Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism.

  American journal of physiology. Heart and circulatory physiology 20091101

• tert-Butyl 3-[2,2-bis-(ethoxy-carbon-yl)vin-yl]-2-bromo-methyl-1H-indole-1-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20091101

• The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract.

  Drug metabolism and disposition: the biological fate of chemicals 20091001

• OSU-A9, a potent indole-3-carbinol derivative, suppresses breast tumor growth by targeting the Akt-NF-kappaB pathway and stress response signaling.

  Carcinogenesis 20091001

• [Effects of indole-3-carbinol on the outcome of tumor and the changes of anti-oxidative system in null mice grafted with nasopharyngeal carcinoma].

  Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20091001

• 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice.

  Inflammatory bowel diseases 20090801

• Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.

  Cancer research 20090801

• Dietary chemopreventive phytochemicals: too little or too much?

  Cancer prevention research (Philadelphia, Pa.) 20090701

• Angiotensin-converting enzyme is a modifier of hypertensive end organ damage.

  The Journal of biological chemistry 20090605

• Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades.

  Clinical immunology (Orlando, Fla.) 20090601

• The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract.

  Journal of applied microbiology 20090601

• 3,3'-diindolylmethane induction of p75NTR-dependent cell death via the p38 mitogen-activated protein kinase pathway in prostate cancer cells.

  Cancer prevention research (Philadelphia, Pa.) 20090601

• Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity.

  International journal of cancer 20090515

• Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cells.

  Journal of cellular physiology 20090401

• Evaluation of indole-based probes for high-throughput screening of drug binding to human serum albumin: Analysis by high-performance affinity chromatography.

  Journal of separation science 20090401

• Effect of boiling on the content of ascorbigen, indole-3-carbinol, indole-3-acetonitrile, and 3,3'-diindolylmethane in fermented cabbage.

  Journal of agricultural and food chemistry 20090325

• Pharmacotherapy of recurrent respiratory papillomatosis: an expert opinion.

  Expert opinion on pharmacotherapy 20090301

• Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats.

  Journal of hypertension 20090301

• Medical treatment of cervical intraepithelial neoplasia II, III: an update review.

  International journal of clinical oncology 20090201

• Indole-3-carbinol inhibits Sp1-induced matrix metalloproteinase-2 expression to attenuate migration and invasion of breast cancer cells.

  Journal of agricultural and food chemistry 20090114

• Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells.

  The Journal of nutrition 20090101

• Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol.

  Retrovirology 20090101

• Ascorbigen: chemistry, occurrence, and biologic properties.

  Clinics in dermatology 20090101

• CYP1B1 mutations in Spanish patients with primary congenital glaucoma: phenotypic and functional variability.

  Molecular vision 20090101

• Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors.

  BMC cancer 20090101

• Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling.

  BMC genomics 20090101

• Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells.

  BMC gastroenterology 20090101

• Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension.

  Vascular pharmacology 20090101

• Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin.

  Breast cancer : basic and clinical research 20090101

• Urinary estrogen metabolites and prostate cancer: a case-control study and meta-analysis.

  Journal of experimental & clinical cancer research : CR 20090101

• Changes in hippocampal metabolites after effective treatment for fibromyalgia: a case study.

  The Clinical journal of pain 20090101

• A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy.

  Molecular cancer 20090101

• Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system.

  Neuro endocrinology letters 20090101

• Loquat (Eriobotrya japonica) extracts suppress the adhesion, migration and invasion of human breast cancer cell line.

  Nutrition research and practice 20090101

• [Effects of indol-3-carbinol and epigallocatexin-3-gallate on alteration and reparation in affected urethra of experimental animals].

  Urologiia (Moscow, Russia : 1999) 20090101

• The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.

  Proceedings of the National Academy of Sciences of the United States of America 20081216

• Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol.

  Cancer prevention research (Philadelphia, Pa.) 20081201

• BRCA1 transcriptional activity is enhanced by interactions between its AD1 domain and AhR.

  Cancer chemotherapy and pharmacology 20081101

• Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.

  Cancer letters 20081008

• Indole-3-carbinol prevents H(2)O(2)-induced inhibition of gap junctional intercellular communication by inactivation of PKB/Akt.

  The Journal of veterinary medical science 20081001

• Synergistic action of dietary phyto-antioxidants on survival and proliferation of ovarian cancer cells.

  Gynecologic oncology 20080901

• Aflatoxin B1 detoxification by CYP321A1 in Helicoverpa zea.

  Archives of insect biochemistry and physiology 20080901

• Cancer is a preventable disease that requires major lifestyle changes.

  Pharmaceutical research 20080901

• Mechanism of decreased susceptibility for Gram-negative bacteria and synergistic effect with ampicillin of indole-3-carbinol.

  Biological & pharmaceutical bulletin 20080901

• Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801

• Indole-3-carbinol suppresses tumor-induced angiogenesis by inhibiting tube formation and inducing apoptosis.

  Bioscience, biotechnology, and biochemistry 20080801

• Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout.

  Environmental health perspectives 20080801

• AH receptor agonist activity in human blood measured with a cell-based bioassay: evidence for naturally occurring AH receptor ligands in vivo.

  Journal of exposure science & environmental epidemiology 20080701

• Inhibitory effects of a dietary phytochemical 3,3'-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

• 5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells.

  Molecular cancer therapeutics 20080701

• Indole-3-carbinol-induced modulation of NF-kappaB signalling is breast cancer cell-specific and does not correlate with cell death.

  Breast cancer research and treatment 20080601

• Identification of indole glucosinolate breakdown products with antifeedant effects on Myzus persicae (green peach aphid).

  The Plant journal : for cell and molecular biology 20080601

• Putative mechanisms of action for indole-3-carbinol in the prevention of colorectal cancer.

  Expert opinion on therapeutic targets 20080601

• 3,3'-Diindolylmethane stimulates murine immune function in vitro and in vivo.

  The Journal of nutritional biochemistry 20080501

• Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines.

  Biochemical pharmacology 20080501

• Indole-3-carbinol as a chemopreventive and anti-cancer agent.

  Cancer letters 20080418

• A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers.

  Toxicologic pathology 20080401

• Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

  Journal of applied toxicology : JAT 20080301

• Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301

• Indole-3-acetonitrile production from indole glucosinolates deters oviposition by Pieris rapae.

  Plant physiology 20080301

• Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.

  Carcinogenesis 20080301

• N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.

  Biochemical pharmacology 20080201

• Recurrent respiratory papillomatosis: an overview of current thinking and treatment.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080201

• Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities.

  Analytical and bioanalytical chemistry 20080201

• Antiplatelet and antithrombotic activity of indole-3-carbinol in vitro and in vivo.

  Phytotherapy research : PTR 20080101

• Renoprotective effects of neuronal NOS-derived nitric oxide and cyclooxygenase-2 metabolites in transgenic rats with inducible malignant hypertension.

  American journal of physiology. Renal physiology 20080101

• Red clover isoflavones biochanin A and formononetin are potent ligands of the human aryl hydrocarbon receptor.

  The Journal of steroid biochemistry and molecular biology 20080101

• Prorenin and glomerulosclerosis?

  Journal of hypertension 20080101

• Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis.

  Journal of hypertension 20080101

• Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer.

  In vivo (Athens, Greece) 20080101

• TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells.

  BMC cancer 20080101

• Selective androgen receptor modulators in preclinical and clinical development.

  Nuclear receptor signaling 20080101

• Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells.

  Drug design, development and therapy 20080101

• Recurrent Respiratory Papillomatosis (RRP)-Juvenile Onset.

  Clinical medicine. Oncology 20080101

• Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study.

  Ecancermedicalscience 20080101

• Inhibition of amyloid fibrillation of lysozyme by indole derivatives--possible mechanism of action.

  The FEBS journal 20071201

• Aldosterone receptor antagonism alleviates proteinuria, but not malignant hypertension, in Cyp1a1-Ren2 transgenic rats.

  American journal of physiology. Renal physiology 20071101

• Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.

  Molecular cancer therapeutics 20071101

• Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells.

  Molecular cancer therapeutics 20071001

• In vitro antimicrobial activity and the mode of action of indole-3-carbinol against human pathogenic microorganisms.

  Biological & pharmaceutical bulletin 20071001

• Short-term modulation of cell proliferation and apoptosis and preventive/therapeutic efficacy of various agents in a mammary cancer model.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070915

• Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.

  Acta pharmacologica Sinica 20070901

• A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells.

  Cancer research 20070815

• Indole-3-carbinol - induced growth inhibition can be converted to a cytotoxic response in the presence of TPA+Ca(2+) in squamous cell carcinoma cell lines.

  FEBS letters 20070807

• Computer-aided rational drug design: a novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling.

  Journal of medicinal chemistry 20070726

• Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.

  The Journal of clinical investigation 20070702

• Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro.

  Carcinogenesis 20070701

• Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels.

  Cancer research 20070701

• Renal vascular and tubulointerstitial inflammation and proliferation in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.

  American journal of physiology. Renal physiology 20070601

• A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals.

  Nutrition reviews 20070601

• The candidacidal activity of indole-3-carbinol that binds with DNA.

  IUBMB life 20070601

• Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.

  Toxicological sciences : an official journal of the Society of Toxicology 20070401

• Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination.

  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20070401

• Allelochemical induction of cytochrome P450 monooxygenases and amelioration of xenobiotic toxicity in Helicoverpa zea.

  Journal of chemical ecology 20070301

• Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.

  Pharmacological research 20070301

• Chemopreventive herbal anti-oxidants: current status and future perspectives.

  Journal of clinical biochemistry and nutrition 20070301

• EGFR and Src are involved in indole-3-carbinol-induced death and cell cycle arrest of human breast cancer cells.

  Carcinogenesis 20070201

• Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis.

  Breast cancer research : BCR 20070101

• The effect of indole-3-carbinol on the expression of CYP1A1, CYP1B1 and AhR genes and proliferation of MCF-7 cells.

  Acta biochimica Polonica 20070101

• Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes.

  BMC evolutionary biology 20070101

• Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines.

  Molecular medicine (Cambridge, Mass.) 20070101

• Sensitive and robust gene expression changes in fish exposed to estrogen--a microarray approach.

  BMC genomics 20070101

• 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice.

  Breast cancer research : BCR 20070101

• Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7.

  BMC pharmacology 20070101

• S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cells.

  BMC cancer 20070101

• Putative cancer chemopreventive agents of dietary origin-how safe are they?

  Nutrition and cancer 20070101

• Effects of prepubertal indole-3-carbinol treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Sprague-Dawley rats.

  In vivo (Athens, Greece) 20070101

• Abstracts of papers presented at the 2007 pittsburgh conference.

  Journal of automated methods & management in chemistry 20070101

• Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.

  Biochemical pharmacology 20061215

• Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20061201

• AT1 receptor blockade is superior to conventional triple therapy in protecting against end-organ damage in Cyp1a1-Ren-2 transgenic rats with inducible hypertension.

  Journal of hypertension 20061201

• Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061201

• A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands.

  Bioorganic & medicinal chemistry letters 20061101

• Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein.

  The American journal of pathology 20061101

• Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells.

  Cellular and molecular life sciences : CMLS 20061101

• Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model.

  Molecular cancer therapeutics 20061101

• Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.

  Mutation research 20061010

• Estrogen receptor alpha as a target for indole-3-carbinol.

  The Journal of nutritional biochemistry 20061001

• Brassica vegetable consumption reduces urinary F2-isoprostane levels independent of micronutrient intake.

  Carcinogenesis 20061001

• Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene.

  Carcinogenesis 20061001

• Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension.

  American journal of physiology. Renal physiology 20060901

• In vivo relevance of two critical levels for NAD(P)H:quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro.

  Toxicology in vitro : an international journal published in association with BIBRA 20060801

• Indole-3-carbinol alters placental cytochrome P450 1A1 and P-glycoprotein levels in rats: a potential role in intensifying fetal intrauterine growth-retardation produced by tobacco smoke.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20060801

• Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae.

  Mutation research 20060725

• Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective.

  Journal of controlled release : official journal of the Controlled Release Society 20060720

• British Association of Paediatric Otorhinolaryngology members experience with recurrent respiratory papillomatosis.

  International journal of pediatric otorhinolaryngology 20060701

• Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers.

  Drug metabolism and disposition: the biological fate of chemicals 20060701

• Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats.

  Journal of the renin-angiotensin-aldosterone system : JRAAS 20060601

• 3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells.

  The Journal of surgical research 20060515

• Molecular targets of dietary agents for prevention and therapy of cancer.

  Biochemical pharmacology 20060514

• Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment.

  Apoptosis : an international journal on programmed cell death 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells.

  Cancer research 20060501

• Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20060501

• Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives.

  Biochemistry 20060418

• Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer.

  The Prostate 20060401

• Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450.

  Toxicology and applied pharmacology 20060301

• Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout.

  Toxicological sciences : an official journal of the Society of Toxicology 20060301

• Using salmonid microarrays to understand the dietary modulation of carcinogenesis in rainbow trout.

  Toxicological sciences : an official journal of the Society of Toxicology 20060301

• Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells.

  Chemical research in toxicology 20060301

• Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane.

  Molecular cancer therapeutics 20060301

• Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells.

  International journal of cancer 20060215

• BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.

  British journal of cancer 20060213

• 3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer.

  Biochemical and biophysical research communications 20060210

• Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats.

  Carcinogenesis 20060201

• Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats.

  Journal of carcinogenesis 20060101

• Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A.

  Breast cancer research : BCR 20060101

• The natural chemopreventive compound indole-3-carbinol: state of the science.

  In vivo (Athens, Greece) 20060101

• A randomized phase II trial of indole-3-carbinol in the treatment of vulvar intraepithelial neoplasia.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101

• A zebrafish assay for identifying neuroprotectants in vivo.

  Neurotoxicology and teratology 20060101

• Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

  Journal of applied toxicology : JAT 20060101

• Transcriptome profiling of human hepatocytes treated with Aroclor 1254 reveals transcription factor regulatory networks and clusters of regulated genes.

  BMC genomics 20060101

• Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

  Journal of applied toxicology : JAT 20060101

• Modulation of apoptosis by cancer chemopreventive agents.

  Mutation research 20051211

• Enhanced tubuloglomerular feedback in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.

  American journal of physiology. Renal physiology 20051201

• Recurrent respiratory papillomatosis: pathogenesis to treatment.

  Current opinion in otolaryngology & head and neck surgery 20051201

• Nutrition and primary prevention of breast cancer: foods, nutrients and breast cancer risk.

  European journal of obstetrics, gynecology, and reproductive biology 20051201

• Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051201

• Indole-3-carbinol. Monograph.

  Alternative medicine review : a journal of clinical therapeutic 20051201

• 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease.

  Biochemical and biophysical research communications 20051125

• Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.

  Carcinogenesis 20051101

• [Current therapeutic options for recurrent respiratory papillomatosis].

  HNO 20051101

• Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis.

  International journal of oncology 20051101

• Molecular targets of dietary polyphenols with anti-inflammatory properties.

  Yonsei medical journal 20051031

• Molecular characterization of the gallate dioxygenase from Pseudomonas putida KT2440. The prototype of a new subgroup of extradiol dioxygenases.

  The Journal of biological chemistry 20051021

• Characterization of the oxidase activity in mammalian catalase.

  The Journal of biological chemistry 20051021

• Re: Xue et al. Effects of analogs of indole-3-carbinol cyclic trimerization, etc. Chem. Biol. Interact. 152 (2005) 119.

  Chemico-biological interactions 20051020

• Interactive effects of superoxide anion and nitric oxide on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertension.

  American journal of physiology. Renal physiology 20051001

• Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.

  Cell cycle (Georgetown, Tex.) 20050901

• Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol.

  European journal of cancer (Oxford, England : 1990) 20050901

• Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells.

  Toxicology letters 20050814

• A phase I study of indole-3-carbinol in women: tolerability and effects.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050801

• Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.

  Blood 20050715

• Inhibition of cell proliferation and in vitro markers of angiogenesis by indole-3-carbinol, a major indole metabolite present in cruciferous vegetables.

  Journal of agricultural and food chemistry 20050629

• Prior exposure to indole-3-carbinol decreases the incidence of specific cyclophosphamide-induced developmental defects in mice.

  Birth defects research. Part B, Developmental and reproductive toxicology 20050601

• Effects of analogs of indole-3-carbinol cyclic trimerization product in human breast cancer cells.

  Chemico-biological interactions 20050415

• Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats.

  American journal of physiology. Renal physiology 20050401

• 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice.

  Carcinogenesis 20050401

• Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

  Journal of biochemistry and molecular biology 20050331

• Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex.

  The Journal of biological chemistry 20050311

• Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner.

  Biochemical and biophysical research communications 20050304

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  Biochemical and biophysical research communications 20050218

• Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis.

  Journal of medical virology 20050201

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  Toxicology and applied pharmacology 20050201

• Targets for indole-3-carbinol in cancer prevention.

  The Journal of nutritional biochemistry 20050201

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  Toxicological sciences : an official journal of the Society of Toxicology 20050101

• Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells.

  Frontiers in bioscience : a journal and virtual library 20050101

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  Oncology reports 20050101

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  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20050101

• Red maca (Lepidium meyenii) reduced prostate size in rats.

  Reproductive biology and endocrinology : RB&E 20050101

• Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells.

  Cancer research 20050101

• Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo.

  Molecular medicine (Cambridge, Mass.) 20050101

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  GMS current topics in otorhinolaryngology, head and neck surgery 20050101

• Cell signaling pathways altered by natural chemopreventive agents.

  Mutation research 20041102

• Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism.

  Carcinogenesis 20041101

• Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma.

  International journal of cancer 20041010

• Indole-3-carbinol activates the cyclin-dependent kinase inhibitor p15(INK4b) gene.

  FEBS letters 20041008

• Induction of apoptosis in human prostate cancer cell line, PC3, by 3,3'-diindolylmethane through the mitochondrial pathway.

  British journal of cancer 20041004

• Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041001

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  Antiviral research 20040901

• An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium.

  British journal of cancer 20040802

• Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040801

• Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells.

  Carcinogenesis 20040701

• Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol.

  Toxicology and applied pharmacology 20040701

• Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040601

• Indole-3-carbinol for recurrent respiratory papillomatosis: long-term results.

  Journal of voice : official journal of the Voice Foundation 20040601

• Inhibition of MUC1 expression by indole-3-carbinol.

  International journal of cancer 20040510

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  Human & experimental toxicology 20040501

• Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium.

  Integrative cancer therapies 20040301

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  Bioscience, biotechnology, and biochemistry 20040301

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  Free radical research 20040301

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  Cell stress & chaperones 20040301

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  Anticancer research 20040101

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  Cancer detection and prevention 20040101

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  Anticancer research 20040101

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  Nutrition and cancer 20040101

• Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis.

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  Anticancer research 20040101

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  Nutrition and cancer 20040101

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  Cancer 20031201

• Broccoli compound inhibits HSV.

  AIDS patient care and STDs 20031101

• A selective irreversible inhibitor targeting a PDZ protein interaction domain.

  Journal of the American Chemical Society 20031008

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  Journal of the American College of Nutrition 20031001

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  ANZ journal of surgery 20030901

• The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030801

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  Toxicological sciences : an official journal of the Society of Toxicology 20030701

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  Toxicological sciences : an official journal of the Society of Toxicology 20030701

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  FEBS letters 20030605

• Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030601

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  Xenobiotica; the fate of foreign compounds in biological systems 20030501

• Cervical dysplasia: early intervention.

  Alternative medicine review : a journal of clinical therapeutic 20030501

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  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030425

• Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.

  Molecular carcinogenesis 20030401

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  Cancer letters 20030128

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• Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.

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  Toxicologic pathology 20030101

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  Mutation research 20030101

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  Mutation research 20030101

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  Mutation research 20030101

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  Nutrition and cancer 20030101

• Chapter 17: Genital human papillomavirus infections--current and prospective therapies.

  Journal of the National Cancer Institute. Monographs 20030101

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  Anticancer research 20030101

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  Microbiological research 20030101

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  Journal of agricultural and food chemistry 20021106

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  Molecular cancer therapeutics 20021101

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  Carcinogenesis 20021001

• Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells.

  Journal of cancer research and clinical oncology 20021001

• Endocrine disruption by indole-3-carbinol and tamoxifen: blockage of ovulation.

  Toxicology and applied pharmacology 20020915

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  Insect molecular biology 20020801

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  Biochemical pharmacology 20020801

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  Expert opinion on pharmacotherapy 20020801

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  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20020801

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  Drug metabolism and disposition: the biological fate of chemicals 20020701

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  Clinical cancer research : an official journal of the American Association for Cancer Research 20020401

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  Alternative medicine review : a journal of clinical therapeutic 20020401

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  The Journal of steroid biochemistry and molecular biology 20020201

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  The Journal of pharmacology and experimental therapeutics 20020101

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  The Journal of pharmacology and experimental therapeutics 20020101

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  IARC scientific publications 20020101

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  Anticancer research 20020101

• A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.

  Journal of pharmacological and toxicological methods 20020101

• Transplacental exposure to indole-3-carbinol induces sex-specific expression of CYP1A1 and CYP1B1 in the liver of Fischer 344 neonatal rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20011201

• Prevention and treatment of cancer with indole-3-carbinol.

  Alternative medicine review : a journal of clinical therapeutic 20011201

• Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression.

  Carcinogenesis 20011101

• Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease.

  The Journal of biological chemistry 20010928

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  Mutation research 20010901

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  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20010901

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  Cancer letters 20010828

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  Cancer research 20010815

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  Drug metabolism and disposition: the biological fate of chemicals 20010801

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  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010801

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  Chemical research in toxicology 20010801

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  Toxicology and applied pharmacology 20010715

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  Drug metabolism and disposition: the biological fate of chemicals 20010701

• Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.

  The Journal of biological chemistry 20010622

• Oxidations of 17beta-estradiol and estrone and their interconversions catalyzed by liver, mammary gland and mammary tumor after acute and chronic treatment of rats with indole-3-carbinol or beta-naphthoflavone.

  Canadian journal of physiology and pharmacology 20010601

• Risk reduction for DDT toxicity and carcinogenesis through dietary modification.

  The journal of the Royal Society for the Promotion of Health 20010601

• Effect of nutritional indoles on activity of xenobiotic metabolism enzymes and T-2 toxicity in rats.

  Bulletin of experimental biology and medicine 20010601

• Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.

  Oncogene 20010524

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20010501

• The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

  Cancer research 20010415

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  Journal of toxicology and environmental health. Part A 20010406

• Molecular biology of the Ah receptor and its role in carcinogenesis.

  Toxicology letters 20010331

• Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats.

  Breast cancer research and treatment 20010301

• 3,3'-diindolylmethane, a major condensation product of indole-3-carbinol, is a potent estrogen in the rainbow trout.

  Toxicology and applied pharmacology 20010201

• Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.

  Carcinogenesis 20010201

• beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.

  Carcinogenesis 20010201

• Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes.

  Chemico-biological interactions 20010130

• Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins.

  The Journal of general virology 20010101

• Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds.

  Environmental toxicology 20010101

• Effects of binary mixtures of six xenobiotics on hormone concentrations and morphometric endpoints of northern bobwhite quail (Colinus virginianus).

  Chemosphere 20010101

• Unsymmetrical methylene derivatives of indoles as antiproliferative agents.

  European journal of medicinal chemistry 20010101

• Concurrent flavin-containing monooxygenase down regulation and cytochrome P450 induction by dietary indoles in the rat: implication for drug-drug interactions.

  Advances in experimental medicine and biology 20010101

• Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity.

  Lupus 20010101

• Comparative tissue-specific toxicities of 20 cancer preventive agents using cultured cells from 8 different normal human epithelia.

  In vitro & molecular toxicology 20010101

• Cruciferous vegetables and cancer prevention.

  Nutrition and cancer 20010101

• Abrogation of estrogen-mediated cellular and biochemical effects by indole-3-carbinol.

  Nutrition and cancer 20010101

• Quantitative determination of 3,3'-diindolylmethane in urine of individuals receiving indole-3-carbinol.

  Nutrition and cancer 20010101

• Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells.

  The Journal of nutrition 20001201

• Role of glutamate 144 and glutamate 164 in the catalytic mechanism of enoyl-CoA hydratase.

  Biochemistry 19990720

• Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1.

  The Biochemical journal 19981101

• Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver--predicting the outcome using early biomarkers.

  Carcinogenesis 19981001

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  Carcinogenesis 19980901

• Expression of the human aryl hydrocarbon receptor complex in yeast. Activation of transcription by indole compounds.

  The Journal of biological chemistry 19971226

• Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells.

  The Journal of biological chemistry 19971212

• Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism.

  Carcinogenesis 19970901

• Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation.

  Biochemical pharmacology 19930309

• Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  Proceedings of the National Academy of Sciences of the United States of America 19911101