71939-50-9 | Dihydroartemisinin

Packsize	Purity	Availability	Price	Discounted Price
1g	96%	in stock	$34.00	$24.00
5g	96%	in stock	$82.00	$58.00
25g	96%	in stock	$171.00	$120.00
100g	96%	in stock	$403.00	$282.00
500g	96%	in stock	$1,179.00	$825.00

Description

• Catalog Number: AB72847
• Chemical Name: Dihydroartemisinin
• CAS Number: 71939-50-9
• Molecular Formula: C15H24O5
• Molecular Weight: 284.3481
• MDL Number: MFCD18323866
• SMILES: OC1O[C@@H]2OC[C@]3(OO[C@@]42[C@H]([C@H]1C)CC[C@H]([C@@H]4C3)C)C

Computed Properties

• Complexity: 415
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• XLogP3: 2.5

Literature

• Toxicity and related mechanisms of dihydroartemisinin on porcine oocyte maturation in vitro.

  Toxicology and applied pharmacology 20180215

• Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner.

  Toxicology and applied pharmacology 20170115

• Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger.

  Antimicrobial agents and chemotherapy 20130701

• Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers.

  Journal of acquired immune deficiency syndromes (1999) 20121101

• Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20121101

• Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle.

  Toxicology 20121009

• Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparum.

  Molecular microbiology 20121001

• Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20120901

• The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis.

  Investigational new drugs 20120801

• Dihydroartemisinin-induced inhibition of proliferation in BEL-7402 cells: an analysis of the mitochondrial proteome.

  Molecular medicine reports 20120801

• Artesunate- and amodiaquine-associated extrapyramidal reactions: a series of 49 cases in VigiBase™.

  Drug safety 20120801

• [Inhibitory effect of dihydroartemisinin on the growth of human prostate cancer PC-3M cells and its mechanism].

  Zhonghua nan ke xue = National journal of andrology 20120701

• In vitro antimalarial activity and drug interactions of fenofibric acid.

  Antimicrobial agents and chemotherapy 20120601

• Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria.

  Drugs 20120507

• Effect of the in vivo activity of dihydroartemisinin against Schistosoma mansoni infection in mice.

  Parasitology research 20120501

• Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo.

  Biochemical pharmacology 20120501

• [Preparation and characterization of dihydroartemisinin/ hydroxypropyl-beta-cyclodextrin inclusion complex].

  Yao xue xue bao = Acta pharmaceutica Sinica 20120401

• Artesunate/dihydroartemisinin pharmacokinetics in acute falciparum malaria in pregnancy: absorption, bioavailability, disposition and disease effects.

  British journal of clinical pharmacology 20120301

• Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria.

  Clinical pharmacology and therapeutics 20120301

• Drug-drug interaction analysis of pyronaridine/artesunate and ritonavir in healthy volunteers.

  The American journal of tropical medicine and hygiene 20120301

• [Effect of dihydroartemisinin on the expression of BCR/ABL fusion gene in leukemia K562 cells].

  Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20120201

• A simplified intravenous artesunate regimen for severe malaria.

  The Journal of infectious diseases 20120115

• Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line.

  Molecular and cellular biochemistry 20120101

• Efficacy and safety of artemisinin-naphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia.

  Malaria journal 20120101

• Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.

  PloS one 20120101

• In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes.

  PloS one 20120101

• Histone deacetylase inhibitors facilitate dihydroartemisinin-induced apoptosis in liver cancer in vitro and in vivo.

  PloS one 20120101

• Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India.

  Malaria journal 20120101

• Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1.

  PloS one 20120101

• The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells.

  Investigational new drugs 20111201

• Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-κB pathway.

  Cancer chemotherapy and pharmacology 20111201

• Antimalarial efficacy of piperaquine-based antimalarial combination therapies: facts and uncertainties.

  Tropical medicine & international health : TM & IH 20111201

• Effects of artemisinin dimers on rat breast cancer cells in vitro and in vivo.

  Anticancer research 20111201

• Highly effective therapy for maternal malaria associated with a lower risk of vertical transmission.

  The Journal of infectious diseases 20111115

• Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trial.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20111115

• Metabolite identification of artemether by data-dependent accurate mass spectrometric analysis using an LTQ-Orbitrap hybrid mass spectrometer in combination with the online hydrogen/deuterium exchange technique.

  Rapid communications in mass spectrometry : RCM 20111115

• Monitoring of artemisinin, dihydroartemisinin, and artemether in environmental matrices using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS).

  Journal of agricultural and food chemistry 20111109

• Cytotoxicity of ethanolic extracts of Artemisia annua to Molt-4 human leukemia cells.

  Planta medica 20111101

• Indolone-N-oxide derivatives: in vitro activity against fresh clinical isolates of Plasmodium falciparum, stage specificity and in vitro interactions with established antimalarial drugs.

  The Journal of antimicrobial chemotherapy 20111101

• A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial.

  PLoS medicine 20111101

• Administrative practices of health professionals and use of artesunate-amodiaquine by community members for treating uncomplicated malaria in southern Ghana: implications for artemisinin-based combination therapy deployment.

  Tropical medicine & international health : TM & IH 20111001

• Hypoxia modulates the effect of dihydroartemisinin on endothelial cells.

  Biochemical pharmacology 20110901

• Effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum.

  Parasitology research 20110801

• Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique.

  Journal of mass spectrometry : JMS 20110801

• [Efficacy of compound dihydroartemisinin/piperaquine in treatment of uncomplicated falciparum malaria in Myanmar].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20110801

• [Advances in research of dihydroartemisinin against parasitic diseases].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110801

• Dihydroartemisinin induces caspase-8-dependent apoptosis in murine GT1-7 hypothalamic neurons.

  Toxicology mechanisms and methods 20110601

• A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue.

  Molecular and biochemical parasitology 20110601

• Dihydroartemisinin-praziquantel combinations and multiple doses of dihydroartemisinin in the treatment of Schistosoma japonicum in experimentally infected mice.

  Annals of tropical medicine and parasitology 20110601

• Synthesis and antimalarial activity of novel dihydro-artemisinin derivatives.

  Molecules (Basel, Switzerland) 20110530

• A liquid-liquid LC/MS/MS assay for the determination of artemether and DHA in malaria patient samples.

  Journal of pharmaceutical and biomedical analysis 20110515

• Antiplasmodial and antitumor activity of dihydroartemisinin analogs derived via the aza-Michael addition reaction.

  Bioorganic & medicinal chemistry letters 20110515

• Anti-tumor effects of dihydroartemisinin on human osteosarcoma.

  Molecular and cellular biochemistry 20110501

• Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo.

  Apoptosis : an international journal on programmed cell death 20110501

• Anticancer effect of dihydroartemisinin (DHA) in a pancreatic tumor model evaluated by conventional methods and optical imaging.

  Anticancer research 20110501

• Improving the solubility and bioavailability of dihydroartemisinin by solid dispersions and inclusion complexes.

  Archives of pharmacal research 20110501

• Stereolability of dihydroartemisinin, an antimalarial drug: a comprehensive thermodynamic investigation. Part 1.

  The Journal of organic chemistry 20110318

• Comparative oral bioavailability of non-fixed and fixed combinations of artesunate and amodiaquine in healthy Indian male volunteers.

  European journal of clinical pharmacology 20110301

• The multiple-dosing pharmacokinetics of artemether, artesunate, and their metabolite dihydroartemisinin in rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20110301

• In-vivo activity of dihydroartemisinin against Schistosoma japonicum.

  Annals of tropical medicine and parasitology 20110301

• Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma.

  Journal of mass spectrometry : JMS 20110201

• Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC.

  Malaria journal 20110101

• Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian children.

  Malaria journal 20110101

• Cytotoxic activity of artemisinin derivatives against cholangiocarcinoma (CL-6) and hepatocarcinoma (Hep-G2) cell lines.

  Asian Pacific journal of cancer prevention : APJCP 20110101

• Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria.

  Malaria journal 20110101

• Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance.

  PloS one 20110101

• Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal.

  Malaria journal 20110101

• Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa.

  Malaria journal 20110101

• Dihydroartemisinin shift the immune response towards Th1, inhibit the tumor growth in vitro and in vivo.

  Cellular immunology 20110101

• Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast.

  PloS one 20110101

• Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges.

  Malaria journal 20110101

• Dihydroartemisinin induces endoplasmic reticulum stress-mediated apoptosis in HepG2 human hepatoma cells.

  Tumori 20110101

• [In vitro anti-Trichomonas vaginalis effects of a mixture of dihydroartemisinin and metronidazole].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20101230

• A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.

  The American journal of tropical medicine and hygiene 20101206

• A simplified liquid chromatography-mass spectrometry assay for artesunate and dihydroartemisinin, its metabolite, in human plasma.

  Molecules (Basel, Switzerland) 20101201

• Selective toxicity of dihydroartemisinin on human CD34+ erythroid cell differentiation.

  Toxicology 20101009

• Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared with artemether-lumefantrine for uncomplicated malaria.

  The American journal of tropical medicine and hygiene 20101005

• Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity.

  Birth defects research. Part B, Developmental and reproductive toxicology 20101001

• The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells.

  FEBS letters 20100924

• Dihydroartemisinin induces apoptosis by a Bak-dependent intrinsic pathway.

  Molecular cancer therapeutics 20100901

• Dihydroartemisinin loaded nanostructured lipid carriers (DHA-NLC): evaluation of pharmacokinetics and tissue distribution after intravenous administration to rats.

  Die Pharmazie 20100901

• Effects of artemisinin derivative on the growth metabolism of Tetrahymena thermophila BF5 based on expression of thermokinetics.

  Biological trace element research 20100701

• Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo.

  Cancer letters 20100701

• Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.

  Biochemical pharmacology 20100701

• Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria.

  European journal of clinical pharmacology 20100701

• The effects of dihydroartemisinin on Giardia lamblia morphology and cell cycle in vitro.

  Parasitology research 20100701

• Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCalpha/Raf/MAPKs and NF-kappaB/AP-1-dependent mechanisms.

  Biochemical pharmacology 20100615

• Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers.

  Chemico-biological interactions 20100607

• Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-kappaB.

  Journal of cancer research and clinical oncology 20100601

• Dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan.

  Annals of tropical medicine and parasitology 20100601

• Dihydroartemisinin upregulates death receptor 5 expression and cooperates with TRAIL to induce apoptosis in human prostate cancer cells.

  Cancer biology & therapy 20100515

• Dihydroartemisinin improves the efficiency of chemotherapeutics in lung carcinomas in vivo and inhibits murine Lewis lung carcinoma cell line growth in vitro.

  Cancer chemotherapy and pharmacology 20100501

• Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso.

  Antimicrobial agents and chemotherapy 20100501

• Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells.

  Anti-cancer drugs 20100401

• Severe congenital malaria acquired in utero.

  The American journal of tropical medicine and hygiene 20100401

• [Experimental study of the function and mechanism combining dihydroartemisinin and gemcitabine in treating pancreatic cancer].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20100401

• Stereodynamic investigation of labile stereogenic centres in dihydroartemisinin.

  Molecules (Basel, Switzerland) 20100305

• Dihydroartemisinin can inhibit calmodulin, calmodulin-dependent phosphodiesterase activity and stimulate cellular immune responses.

  International immunopharmacology 20100201

• Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope.

  Parasitology research 20100201

• Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda.

  Malaria journal 20100101

• Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial.

  Malaria journal 20100101

• The pharmaceutical death-ride of dihydroartemisinin.

  Malaria journal 20100101

• An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.

  PloS one 20100101

• Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects.

  Malaria journal 20100101

• Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine.

  Malaria journal 20100101

• Development and validation of a high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemether and its active metabolite dihydroartemisinin in human plasma.

  Journal of pharmaceutical and biomedical analysis 20091205

• Progress in the development of piperaquine combinations for the treatment of malaria.

  Current opinion in infectious diseases 20091201

• Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091201

• Artemisinin combination therapy for malaria: beyond good efficacy.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091201

• Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.

  European journal of clinical pharmacology 20091001

• Artemisinin-transferrin conjugate retards growth of breast tumors in the rat.

  Anticancer research 20091001

• Comparative study of dihydroartemisinin and artesunate safety in healthy Thai volunteers.

  International journal of clinical pharmacology and therapeutics 20090901

• Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells.

  Bioorganic & medicinal chemistry letters 20090801

• [In vivo effect of dihydroartemisinin and azithromycin on the ultrastructure of Toxoplasma gondii tachyzoites].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20090801

• Artemisinin resistance in Plasmodium falciparum malaria.

  The New England journal of medicine 20090730

• Artemisinin-based combination therapy for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20090708

• Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy.

  Journal of cellular and molecular medicine 20090701

• Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.

  Experimental parasitology 20090701

• Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene.

  The American journal of tropical medicine and hygiene 20090701

• [Study on anticancer effect of dihydroartemisinin on pancreatic cancer].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20090701

• A randomized, controlled trial of artemisinin-piperaquine vs dihydroartemisinin-piperaquine phosphate in treatment of falciparum malaria.

  Chinese journal of integrative medicine 20090601

• Severe idiosyncratic drug reaction (Lyells syndrome) after ingesting dihydroartemisinin.

  Nigerian journal of clinical practice 20090601

• Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam.

  Tropical medicine & international health : TM & IH 20090501

• A liquid chromatographic-tandem mass spectrometric method for determination of artemether and its metabolite dihydroartemisinin in human plasma.

  Bioanalysis 20090401

• Antimalarial therapies in children from Papua New Guinea.

  The New England journal of medicine 20090319

• Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica.

  The Journal of antimicrobial chemotherapy 20090301

• Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215

• Application of a liquid chromatography/tandem mass spectrometry method for the pharmacokinetic study of dihydroartemisinin injectable powder in healthy Chinese subjects.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215

• Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo.

  Anti-cancer drugs 20090201

• Dihydroartemisinin-cyclodextrin complexation: solubility and stability.

  Archives of pharmacal research 20090101

• Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells.

  Journal of biomedical science 20090101

• Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats.

  Malaria journal 20090101

• Dihydroartemisinin pharmacokinetics in patients with malaria after multiple doses--assembling clues and perspectives.

  Drug metabolism and pharmacokinetics 20090101

• Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis.

  PloS one 20090101

• Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children.

  PloS one 20090101

• Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial.

  PloS one 20090101

• Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children.

  Malaria journal 20090101

• Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.

  Malaria journal 20090101

• Pharmacokinetics and pharmacodynamics of a new ACT formulation: Artesunate/Amodiaquine (TRIMALACT) following oral administration in African malaria patients.

  European journal of drug metabolism and pharmacokinetics 20090101

• A trial of combination antimalarial therapies in children from Papua New Guinea.

  The New England journal of medicine 20081211

• Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081201

• A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081201

• On-column epimerization of dihydroartemisinin: an effective analytical approach to overcome the shortcomings of the International Pharmacopoeia monograph.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081101

• Development and validation of a liquid chromatography-mass spectrometry method for the simultaneous quantification of artesunate and dihydroartemisinin in human plasma.

  The Southeast Asian journal of tropical medicine and public health 20081101

• Absence of time-dependent artesunate pharmacokinetics in healthy subjects during 5-day oral administration.

  European journal of clinical pharmacology 20081001

• Pharmacokinetics of artesunate in the domestic pig.

  The Journal of antimicrobial chemotherapy 20080901

• Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum calcium adenosine triphosphatase activity.

  Basic & clinical pharmacology & toxicology 20080901

• Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080901

• [Effects of dihydroartiminisin on proliferation and phosphorylation of mitogen-activated protein kinase in epithelial ovarian cancer cell lines].

  Zhonghua fu chan ke za zhi 20080901

• Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX).

  Reproductive toxicology (Elmsford, N.Y.) 20080801

• The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese volunteers.

  Acta tropica 20080801

• Embryotoxicity of artesunate in animal species related to drug tissue distribution and toxicokinetic profiles.

  Birth defects research. Part B, Developmental and reproductive toxicology 20080801

• Artesunate: developmental toxicity and toxicokinetics in monkeys.

  Birth defects research. Part B, Developmental and reproductive toxicology 20080801

• Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species.

  Cancer biology & therapy 20080701

• [Analyzing anti-cancer action mechanisms of dihydroartemisinin using gene chip].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701

• Micronization of dihydroartemisinin by rapid expansion of supercritical solutions.

  Drug development and industrial pharmacy 20080601

• [Dihydroartemisinin down-regulates the expression of transferrin receptor in myeloid leukemia cells].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080601

• Comparison of HPLC with electrochemical detection and LC-MS/MS for the separation and validation of artesunate and dihydroartemisinin in animal and human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080515

• Pharmacokinetics of dihydroartemisinin in Artekin tablets for single and repeated dosing in Chinese healthy volunteers.

  Biopharmaceutics & drug disposition 20080501

• Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080501

• Human fortilin is a molecular target of dihydroartemisinin.

  FEBS letters 20080402

• The role of calcium, P38 MAPK in dihydroartemisinin-induced apoptosis of lung cancer PC-14 cells.

  Cancer chemotherapy and pharmacology 20080401

• Plasmodium berghei: parasite clearance after treatment with dihydroartemisinin in an asplenic murine malaria model.

  Experimental parasitology 20080401

• Biological activity of dihydroartemisinin in canine osteosarcoma cell lines.

  American journal of veterinary research 20080401

• Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report.

  The American journal of tropical medicine and hygiene 20080401

• Pharmacokinetics of dihydroartemisinin in a murine malaria model.

  The American journal of tropical medicine and hygiene 20080401

• Optimization of an LC-MS method for the determination of artesunate and dihydroartemisinin plasma levels using liquid-liquid extraction.

  Journal of analytical toxicology 20080301

• Formation, physical stability and in vitro antimalarial activity of dihydroartemisinin nanosuspensions obtained by co-grinding method.

  Drug development and industrial pharmacy 20080301

• Solid dispersions of dihydroartemisinin in polyvinylpyrrolidone.

  Archives of pharmacal research 20080301

• Dihydroartemisinin induces apoptosis in human leukemia cells HL60 via downregulation of transferrin receptor expression.

  Anti-cancer drugs 20080301

• [Efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in Hainan, China].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20080227

• [Experimental treatment using combined Fructus psoraleae and dihydroartemisinin in mouse cryptosporidiosis].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20080227

• Orally active esters of dihydroartemisinin: Synthesis and antimalarial activity against multidrug-resistant Plasmodium yoelii in mice.

  Bioorganic & medicinal chemistry letters 20080215

• Dihydroartemisinin potentiates the cytotoxic effect of temozolomide in rat C6 glioma cells.

  Pharmacology 20080101

• Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.

  PloS one 20080101

• Pharmacokinetics of a five-day oral dihydroartemisinin monotherapy regimen in patients with uncomplicated falciparum malaria.

  Drug metabolism and pharmacokinetics 20080101

• A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya.

  Malaria journal 20080101

• Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin.

  International journal for parasitology 20071201

• Pharmacodynamics of doxycycline in a murine malaria model.

  Antimicrobial agents and chemotherapy 20071201

• A new decomposition product of dihydroartemisinin.

  Die Pharmazie 20071201

• Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: implications for embryotoxicity.

  Toxicology 20071120

• Evaluation of the safety and relative bioavailability of a new dihydroartemisinin tablet formulation in healthy Thai volunteers.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20071001

• Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug.

  ChemMedChem 20071001

• An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological studies of the drug combination.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001

• Antimalarial drug quality in Africa.

  Journal of clinical pharmacy and therapeutics 20071001

• Efficacy and safety of dihydroartemisinin-piperaquine.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20070901

• Assessment of in vitro antimalarial interactions between dihydroartemisinin and fosmidomycin.

  The Southeast Asian journal of tropical medicine and public health 20070901

• Dihydroartemisinin is an inhibitor of ovarian cancer cell growth.

  Acta pharmacologica Sinica 20070701

• Clinical efficacy of high dose monotherapy of oral dihydroartemisinin in uncomplicated falciparum malaria in viet nam.

  Japanese journal of infectious diseases 20070701

• Rectal administration of artemisinin derivatives for the treatment of malaria.

  JAMA 20070606

• Liquid chromatography-tandem mass spectrometry assay for the quantitation of beta-dihydroartemisinin in rat plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

• Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1alpha activation in C6 glioma cells.

  The Journal of pharmacy and pharmacology 20070601

• CD4 count, viral load and parasite density of HIV positive individuals undergoing malaria treatment with dihydroartemisinin in Benin City, Edo state, Nigeria.

  Journal of vector borne diseases 20070601

• [Dihydroartemisinin inhibits proliferation and induces apoptosis of rat glioma C6 cells].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070501

• Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070415

• Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison.

  Lancet (London, England) 20070303

• Pharmacokinetics of mefloquine with dihydroartemisinin as 2-day regimens in patients with uncomplicated falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20070301

• [Effect of dihydroartemisinin on the ultrastructure of Trichomonas vaginalis trophozoites in vitro].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20070227

• In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).

  The American journal of tropical medicine and hygiene 20070201

• A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia.

  Tropical medicine & international health : TM & IH 20070201

• Quality control of active ingredients in artemisinin-derivative antimalarials within Kenya and DR Congo.

  Tropical medicine & international health : TM & IH 20070101

• Dihydroartemisinin suppository in moderately severe malaria: comparative efficacy of dihydroartemisinin suppository versus intramuscular artemeter followed by oral sulfadoxine-pyrimethamine in the management of moderately severe malaria in Nigerian children.

  The American journal of tropical medicine and hygiene 20070101

• Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells.

  Methods and findings in experimental and clinical pharmacology 20070101

• Induction of apoptosis and inhibition of cell migration and tube-like formation by dihydroartemisinin in murine lymphatic endothelial cells.

  Pharmacology 20070101

• Neurotoxicity and toxicokinetics of artelinic acid following repeated oral administration in rats.

  International journal of toxicology 20070101

• A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru.

  PloS one 20070101

• In vitro interaction of dihydroartemisin and lumefantrine in clinical field isolates from Bangladesh.

  Wiener klinische Wochenschrift 20070101

• [In vitro interaction studies of azithromycin and dihydroartemisinin in Plasmodium falciparum isolates from Bangladesh].

  Wiener klinische Wochenschrift 20070101

• Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20061201

• Treatment of malaria in a mouse model by intranasal drug administration.

  International journal for parasitology 20061201

• Characterization of human urinary metabolites of the antimalarial piperaquine.

  Drug metabolism and disposition: the biological fate of chemicals 20061201

• The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.

  European journal of clinical pharmacology 20061201

• The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria.

  European journal of clinical pharmacology 20061201

• In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos.

  Reproductive toxicology (Elmsford, N.Y.) 20061101

• Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients.

  PLoS medicine 20061101

• Resistance to dihydroartemisinin.

  Emerging infectious diseases 20061101

• Artesunate and a major metabolite, dihydroartemisinin, diminish mitogen-induced lymphocyte proliferation and activation.

  The Southeast Asian journal of tropical medicine and public health 20060901

• Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation.

  International immunopharmacology 20060801

• An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos).

  Tropical medicine & international health : TM & IH 20060801

• Dihydroartemisinin inhibits angiogenesis induced by multiple myeloma RPMI8226 cells under hypoxic conditions via downregulation of vascular endothelial growth factor expression and suppression of vascular endothelial growth factor secretion.

  Anti-cancer drugs 20060801

• Artemisinin combination therapies.

  Lancet (London, England) 20060624

• Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.

  Lancet (London, England) 20060624

• In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20060601

• Artesunate and artemether are effective fasciolicides in the rat model and in vitro.

  The Journal of antimicrobial chemotherapy 20060601

• Manslaughter by fake artesunate in Asia--will Africa be next?

  PLoS medicine 20060601

• Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.

  European journal of clinical pharmacology 20060501

• Pharmacokinetics of piperaquine after repeated oral administration of the antimalarial combination CV8 in 12 healthy male subjects.

  European journal of clinical pharmacology 20060501

• A dimer of alpha- and beta-dihydroartemisinin: bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether.

  Acta crystallographica. Section C, Crystal structure communications 20060501

• Dihydroartemisinin enhances radiosensitivity of human glioma cells in vitro.

  Journal of cancer research and clinical oncology 20060201

• Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro.

  Reproductive toxicology (Elmsford, N.Y.) 20060101

• Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells.

  Cancer chemotherapy and pharmacology 20060101

• Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo.

  Cancer research 20051201

• In vitro interactions of Aspilia africana (Pers.) C.D. Adams, a traditional antimalarial medicinal plant, with artemisinin against Plasmodium falciparum.

  Journal of ethnopharmacology 20051114

• [Dihydroartemisinin inhibits the expression of vascular endothelial growth factor in K562 cells].

  Yao xue xue bao = Acta pharmaceutica Sinica 20051101

• [Effect of dihydroartemisinin on ultrastructure of Giardia lamblia in vitro].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20051030

• Pharmacokinetics of the diastereomers of arteether, a potent antimalarial drug, in rats.

  Biopharmaceutics & drug disposition 20050901

• An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20050901

• A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815

• Once-daily combination therapy for uncomplicated malaria: is this the way forward?

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815

• Efficacy comparison between anti-malarial drugs in Africans presenting with mild malaria in the Central Republic of Africa: a preliminary study.

  Parasite (Paris, France) 20050301

• Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225

• [Effects of combined artemether and dihydroarteamisinin in treatment of children with falciparum malaria].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20050101

• Pharmacokinetics of the four combination regimens of dihydroartemisinin/mefloquine in acute uncomplicated falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20050101

• Investigation of bioavailability, pharmacokinetics and safety of new pediatric formulations of artesunate and mefloquine.

  The Southeast Asian journal of tropical medicine and public health 20050101

• In vitro antimalarial drug susceptibility in Thai border areas from 1998-2003.

  Malaria journal 20050101

• Toxicokinetics and hydrolysis of artelinate and artesunate in malaria-infected rats.

  International journal of toxicology 20050101

• Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells.

  Anticancer research 20050101

• Comparison of the bioequivalence of three oral formulations of dihydroartemisinin based on ex vivo blood schizontocidal activities against Plasmodium falciparum.

  The American journal of tropical medicine and hygiene 20041201

• Pharmacokinetic investigation on the therapeutic potential of artemotil (beta-arteether) in Thai patients with severe Plasmodium falciparum malaria.

  The American journal of tropical medicine and hygiene 20041201

• Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.

  The Journal of infectious diseases 20041115

• The pharmacokinetics of oral dihydroartemisinin and artesunate in healthy Thai volunteers.

  The Southeast Asian journal of tropical medicine and public health 20040901

• Activity of dihydroartemisinin against Leishmania donovani both in vitro and vivo.

  Chinese medical journal 20040801

• Antimalarial dihydroartemisinin also inhibits angiogenesis.

  Cancer chemotherapy and pharmacology 20040501

• Synthesis of O-aminodihydroartemisinin via TMS triflate catalyzed C-O coupling reaction.

  The Journal of organic chemistry 20040430

• Design of a dissolution system for the evaluation of the release rate characteristics of artemether and dihydroartemisinin from tablets.

  International journal of pharmaceutics 20040415

• Protein binding and alpha : beta anomer ratio of dihydroartemisinin in vivo.

  British journal of clinical pharmacology 20040401

• Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria.

  British journal of clinical pharmacology 20040201

• CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.

  Tropical medicine & international health : TM & IH 20040201

• Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial.

  Lancet (London, England) 20040103

• Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria.

  British journal of clinical pharmacology 20040101

• Artemisinin induces apoptosis in human cancer cells.

  Anticancer research 20040101

• Effect of dihydroartemisinin on the antioxidant capacity of P. falciparum-infected erythrocytes.

  The Southeast Asian journal of tropical medicine and public health 20031201

• Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro.

  Pharmacological research 20030901

• Comparison of bioassay and high performance liquid chromatographic assay of artesunate and dihydroartemisinin in plasma.

  Acta tropica 20030801

• A sensitive and selective liquid chromatographic/electrospray ionization tandem mass spectrometric assay for the simultaneous quantification of alpha-,beta-arteether and its metabolite dihydroartemisinin in plasma, useful for pharmacokinetic studies.

  Journal of mass spectrometry : JMS 20030701

• Comparative clinical trial of two-fixed combinations dihydroartemisinin-napthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand.

  The Southeast Asian journal of tropical medicine and public health 20030601

• Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021215

• Modulation of multidrug resistance by artemisinin, artesunate and dihydroartemisinin in K562/adr and GLC4/adr resistant cell lines.

  Biological & pharmaceutical bulletin 20021201

• Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases.

  Drug metabolism and disposition: the biological fate of chemicals 20020901

• An open randomized clinical trial of Artecom vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.

  The Southeast Asian journal of tropical medicine and public health 20020901

• A comparative clinical trial of combinations of dihydroartemisinin plus azithromycin and dihydroartemisinin plus mefloquine for treatment of multidrug resistant falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20020901

• Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020715

• Membrane heme as a host factor in reducing effectiveness of dihydroartemisinin.

  Biochemical pharmacology 20020701

• Relative bioavailability of artesunate and dihydroartemisinin: investigations in the isolated perfused rat liver and in healthy Caucasian volunteers.

  The American journal of tropical medicine and hygiene 20020201

• The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria.

  British journal of clinical pharmacology 20020101

• Assessment of the neurotoxicity of oral dihydroartemisinin in mice.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20020101

• [Pharmacokinetic studies on artemether under conditions simulated in vivo].

  Se pu = Chinese journal of chromatography 20020101

• [Therapeutic effect of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20020101

• [Study on treatment of multi-drug resistant falciparum malaria by using a combination of dihydroartemisinin and pyronaridine].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20020101

• The effect of 10 alpha-trifluoromethylhydroartemisinin on Plasmodium berghei infection and its toxicity in experimental animals.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20020101

• Authentication of artemether, artesunate and dihydroartemisinin antimalarial tablets using a simple colorimetric method.

  Tropical medicine & international health : TM & IH 20011201

• Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria.

  The American journal of tropical medicine and hygiene 20011201

• Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells.

  Life sciences 20011121

• Multiple dose study of interactions between artesunate and artemisinin in healthy volunteers.

  British journal of clinical pharmacology 20011001

• Ammunition against malaria.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20010904

• Antimalarial activity of azithromycin, artemisinin and dihydroartemisinin in fresh isolates of Plasmodium falciparum in Thailand.

  Acta tropica 20010901

• Oral bioavailability of dihydroartemisinin in Vietnamese volunteers and in patients with falciparum malaria.

  British journal of clinical pharmacology 20010601

• Efficacy of dihydroartemisinin-mefloquine on acute uncomplicated falciparum malaria.

  Chinese medical journal 20010601

• Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.

  Journal of medicinal chemistry 20010426

• [In vitro study of the anti-pneumocystis carinii effect of arteminsin derivatives].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20010301

• The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro.

  Biochemical pharmacology 20010215

• Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.

  Journal of medicinal chemistry 20010104