74209-34-0 | 3-Bromo-7-nitro-1H-indazole

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$7.00	$5.00
1g	98%	in stock	$12.00	$9.00
5g	98%	in stock	$33.00	$23.00
10g	98%	in stock	$62.00	$44.00
25g	98%	in stock	$116.00	$81.00
100g	98%	in stock	$423.00	$296.00

Description

• Catalog Number: AB64530
• Chemical Name: 3-Bromo-7-nitro-1H-indazole
• CAS Number: 74209-34-0
• Molecular Formula: C7H4BrN3O2
• Molecular Weight: 242.0296
• MDL Number: MFCD00159910
• SMILES: [O-][N+](=O)c1cccc2c1[nH]nc2Br

Computed Properties

• Complexity: 220
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• XLogP3: 2.4

Literature

• S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease.

  Molecular neurodegeneration 20130101

• Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress.

  Basic & clinical pharmacology & toxicology 20120901

• Photoperiod-dependent effects of neuronal nitric oxide synthase inhibition on aggression in Siberian hamsters.

  Hormones and behavior 20120201

• 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP.

  Life sciences 20120116

• Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats.

  Life sciences 20111205

• Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS.

  American journal of physiology. Heart and circulatory physiology 20111001

• The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105

• Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.

  Oral diseases 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Dynamic and interacting profiles of *NO and O2 in rat hippocampal slices.

  Free radical biology & medicine 20100415

• Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.

  Bioorganic & medicinal chemistry 20090901

• Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase.

  Neuroscience 20090317

• Signaling mechanisms of interferon gamma induced apoptosis in chromaffin cells: involvement of nNOS, iNOS, and NFkappaB.

  Journal of neurochemistry 20090201

• Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.

  Bioorganic & medicinal chemistry 20080601

• Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing.

  Behavioural brain research 20080211

• NMDA inhibitors cause apoptosis of pyramidal neurons in mature piriform cortex: evidence for a nitric oxide-mediated effect involving inhibitory interneurons.

  Neuropharmacology 20070601

• Impaired nitric oxide synthase signaling dissociates social investigation and aggression.

  Behavioral neuroscience 20070401

• An AMPA glutamatergic receptor activation-nitric oxide synthesis step signals transsynaptic apoptosis in limbic cortex.

  Neuropharmacology 20060701

• Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat.

  Progress in neuro-psychopharmacology & biological psychiatry 20060101

• [Effects of new nitric oxide synthase inhibitors on spontaneous locomotor activity].

  Medicinski pregled 20060101

• Effect of N-acetylaspartylglutamate (NAAG) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat.

  Journal of neurochemistry 20050701

• Sensory nitrergic meningeal vasodilatation and non-nitrergic plasma extravasation in anaesthesized rats.

  European journal of pharmacology 20040830

• Study on the influence of potent inhibitors of neuronal nitric oxide synthase on the antinociceptive and anticonvulsant activity of benzodiazepines in mice.

  Polish journal of pharmacology 20030101

• Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.

  Neuroscience 20030101

• Consequences of nitric oxide generation in epileptic-seizure rodent models as studied by in vivo EPR.

  Magnetic resonance in medicine 20021201

• Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.

  Biochemistry 20021126

• The vasorelaxant effect of pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide in isolated rat basilar arteries is partially mediated by activation of nitrergic neurons.

  Regulatory peptides 20020715

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Prolonged increase in ciliary beat frequency after short-term purinergic stimulation in human airway epithelial cells.

  The Journal of physiology 20020115

• Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.

  Biochemistry 20011113

• Ischemia-reperfusion injury of the cochlea: effects of an iron chelator and nitric oxide synthase inhibitors.

  Hearing research 20011001

• Differential frequency-dependent regulation of transmitter release by endogenous nitric oxide at the amphibian neuromuscular synapse.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010215

• Neuronal NOS inhibitor that reduces oxidative DNA lesions and neuronal sensitivity increases the expression of intact c-fos transcripts after brain injury.

  Journal of biomedical science 20010101

• nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice.

  Neuroreport 20000911

• Anticonvulsant activity of new and potent inhibitors of nitric oxide synthase.

  Brain research bulletin 19970101

• 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase.

  Life sciences 19950101