74772-77-3 | 5-(4-((1-Methylcyclohexyl)methoxy)benzyl)thiazolidine-2,4-dione

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$30.00	$21.00
5mg	≥98%	in stock	$129.00	$90.00
10mg	≥98%	in stock	$228.00	$160.00
50mg	≥98%	in stock	$984.00	$689.00

Description

• Catalog Number: AB72042
• Chemical Name: 5-(4-((1-Methylcyclohexyl)methoxy)benzyl)thiazolidine-2,4-dione
• CAS Number: 74772-77-3
• Molecular Formula: C18H23NO3S
• Molecular Weight: 333.4451
• MDL Number: MFCD00865499
• SMILES: O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCCCC1

Computed Properties

• Complexity: 440
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• Undefined Atom Stereocenter Count: 1
• XLogP3: 4.8

Literature

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  European journal of cell biology 20120801

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• Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.

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• SR-PSOX at sites predisposed to atherosclerotic lesion formation mediates monocyte-endothelial cell adhesion.

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• Combination of ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, and cisplatin enhances the inhibition of growth of human ovarian cancers.

  Journal of cancer research and clinical oncology 20110801

• Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors.

  Journal of medicinal chemistry 20110728

• Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells.

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• 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma.

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• Troglitazone suppresses c-Myc levels in human prostate cancer cells via a PPARγ-independent mechanism.

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• Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPARγ activation in non-small cell lung carcinoma A549 cells.

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• Pigment epithelial-derived factor inhibits c-FLIP expression and assists ciglitazone-induced apoptosis in hepatocellular carcinoma.

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• Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression.

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• Combined treatment with the Cox-2 inhibitor niflumic acid and PPARγ ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells.

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• Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids.

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• Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells.

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• Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth.

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• Specific thiazolidinediones inhibit ovarian cancer cell line proliferation and cause cell cycle arrest in a PPARγ independent manner.

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• Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.

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• Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.

  Glia 20101101

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• Peroxisome proliferator-activated receptor gamma promotes neuroprotection by modulating cyclin D1 expression after focal cerebral ischemia.

  Canadian journal of physiology and pharmacology 20100701

• Effect of BMP-9 and its derived peptide on the differentiation of human white preadipocytes.

  Growth factors (Chur, Switzerland) 20100601

• Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro.

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• The MAPK-dependent regulation of the Jagged/Notch gene expression by VEGF, bFGF or PPAR gamma mediated angiogenesis in HUVEC.

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  Respirology (Carlton, Vic.) 20100201

• Opposite effects of two thiazolidinediones, ciglitazone and troglitazone, on proteinase-activated receptor-1-triggered prostaglandin E(2) release.

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• Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock.

  American journal of physiology. Gastrointestinal and liver physiology 20100101

• PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis.

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  Journal of experimental & clinical cancer research : CR 20100101

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• Down-regulation of lipoprotein lipase increases glucose uptake in L6 muscle cells.

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• Peroxisome-proliferator activator receptor-gamma activation decreases attachment of endometrial cells to peritoneal mesothelial cells in an in vitro model of the early endometriotic lesion.

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• Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma.

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• Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels.

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• Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis.

  Experimental dermatology 20090701

• Peroxisome proliferator-activated receptor gamma negatively regulates allergic rhinitis in mice.

  Allergology international : official journal of the Japanese Society of Allergology 20090601

• Peroxisome proliferator-activated receptor-gamma and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells.

  Fertility and sterility 20090501

• In vitro and in vivo anti-melanoma effects of ciglitazone.

  The Journal of investigative dermatology 20090501

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  Cancer letters 20090418

• Peroxisome proliferator-activated receptor {gamma} stimulation of adipocyte ApoE gene transcription mediated by the liver receptor X pathway.

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• Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.

  Endocrinology 20090401

• Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3.

  American journal of physiology. Endocrinology and metabolism 20090401

• Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells.

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  Experimental neurology 20090401

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• Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca(2+) in opossum kidney cells.

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  Critical care medicine 20090201

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• Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells.

  World journal of gastroenterology 20090121

• Thiazolidinediones regulate expression of cell cycle proteins in human prostate cancer cells via PPARgamma-dependent and PPARgamma-independent pathways.

  Cell cycle (Georgetown, Tex.) 20090115

• Effect of peroxisome proliferator-activated receptor-gamma on airway smooth muscle thickening in a murine model of chronic asthma.

  International archives of allergy and immunology 20090101

• Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells.

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• Involvement of peroxisome proliferator-activated receptor gamma in gonadal steroidogenesis and steroidogenic acute regulatory protein expression.

  Reproduction, fertility, and development 20090101

• CD36 signaling inhibits the translation of heat shock protein 70 induced by oxidized low density lipoprotein through activation of peroxisome proliferators-activated receptor gamma.

  Experimental & molecular medicine 20081231

• 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081201

• Molecular characterization of peroxisome proliferator-activated receptors (PPARs) and their gene expression in the differentiating adipocytes of red sea bream Pagrus major.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20081101

• Ciglitazone, a PPARgamma agonist, ameliorates diabetic nephropathy in part through homocysteine clearance.

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• Peroxisome proliferator-activated receptor gamma overexpression suppresses growth and induces apoptosis in human multiple myeloma cells.

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  Molecular pharmacology 20081001

• Troglitazone increases IL-1beta induced cyclooxygenase-2 and inducible nitric oxide synthase expression via enhanced phosphorylation of IkappaBalpha in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats.

  Biological & pharmaceutical bulletin 20081001

• Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock.

  Critical care medicine 20081001

• Systemic PPARgamma ligation inhibits allergic immune response in the skin.

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• Modulation of cell growth and PPARgamma expression in human colorectal cancer cell lines by ciglitazone.

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• Molecular mechanism of protection against chemically and gamma-radiation induced apoptosis in human colon cancer cells.

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• PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91.

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  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080521

• Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms.

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• PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis.

  American journal of physiology. Lung cellular and molecular physiology 20080501

• Pharmacological exploitation of the peroxisome proliferator-activated receptor gamma agonist ciglitazone to develop a novel class of androgen receptor-ablative agents.

  Journal of medicinal chemistry 20080410

• Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression.

  Bone 20080401

• The synthetic peroxisome proliferator-activated receptor-gamma agonist ciglitazone attenuates neuroinflammation and accelerates encapsulation in bacterial brain abscesses.

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• Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells.

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  Endocrinology 20080301

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• Methacholine-induced pulmonary gas trapping in a mouse model of allergic asthma: effect of inhaled budesonide and ciglitazone.

  European journal of pharmacology 20080106

• PPAR and LXR activators regulate ABCA12 expression in human keratinocytes.

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  International journal of oncology 20080101

• PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice.

  International journal of biological sciences 20080101

• Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma.

  Prostaglandins, leukotrienes, and essential fatty acids 20080101

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  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

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  Anticancer research 20080101

• Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.

  The EMBO journal 20071212

• Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells.

  Shock (Augusta, Ga.) 20071201

• Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes.

  Pflugers Archiv : European journal of physiology 20071201

• Minor polar compounds extra-virgin olive oil extract (MPC-OOE) inhibits NF-kappa B translocation in human monocyte/macrophages.

  Pharmacological research 20071201

• Transcriptional upregulation of gastrin in response to peroxisome proliferator-activated receptor gamma agonist triggers cell survival pathways.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071201

• Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt.

  Shock (Augusta, Ga.) 20071101

• Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management.

  Gut 20071101

• Capacitative calcium entry contributes to the differential transactivation of the epidermal growth factor receptor in response to thiazolidinediones.

  Molecular pharmacology 20071101

• Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone.

  Molecular human reproduction 20071101

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  Mini reviews in medicinal chemistry 20071101

• [Molecular mechanism of ciglitazone inhibiting the expression of extracellular matrix in human hepatic stellate cells].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20071101

• Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db mice.

  European journal of pharmacology 20071015

• Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones.

  Cardiovascular research 20071001

• Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.

  European journal of pharmacology 20071001

• Investigation of the lipophilic behaviour of some thiazolidinediones. Relationships with PPAR-gamma activity.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001

• PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats.

  Bone 20071001

• Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell lines.

  Toxicology in vitro : an international journal published in association with BIBRA 20070901

• Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation.

  Molecular pharmacology 20070901

• Quantification of PPAR-gamma protein in monocyte/macrophages from healthy smokers and non-smokers: a possible direct effect of nicotine.

  Life sciences 20070823

• Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, on the growth of human ovarian cancers.

  Cancer 20070815

• Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells.

  Molecular and cellular biochemistry 20070801

• Ciglitazone, a peroxisome proliferator-activated receptor gamma inducer, ameliorates renal preglomerular production and activity of angiotensin II and thromboxane A2 in glycerol-induced acute renal failure.

  The Journal of pharmacology and experimental therapeutics 20070801

• Glitazones induce astroglioma cell death by releasing reactive oxygen species from mitochondria: modulation of cytotoxicity by nitric oxide.

  Molecular pharmacology 20070801

• Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system.

  British journal of pharmacology 20070801

• Mitochondria, ciglitazone and liver: a neglected interaction in biochemical pharmacology.

  European journal of pharmacology 20070712

• Pro-MMP-2 activation by the PPARgamma agonist, ciglitazone, induces cell invasion through the generation of ROS and the activation of ERK.

  FEBS letters 20070710

• Ciglitazone mediates COX-2 dependent suppression of PGE2 in human non-small cell lung cancer cells.

  Prostaglandins, leukotrienes, and essential fatty acids 20070701

• Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells.

  Molecular pharmacology 20070601

• A role for inflammatory mediators in the IL-18 mediated attenuation of LTP in the rat dentate gyrus.

  Neuropharmacology 20070601

• Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines?

  Archives of biochemistry and biophysics 20070601

• Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070501

• Transdifferentiation of porcine satellite cells to adipoblasts with ciglitizone.

  Journal of animal science 20070501

• Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor gamma-dependent manner.

  International journal of oncology 20070501

• A peroxisome-proliferator activated receptor-gamma ligand could regulate the expression of leptin receptor on human hepatic stellate cells.

  Histochemistry and cell biology 20070501

• Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells.

  Immunology 20070501

• Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.

  Cellular and molecular life sciences : CMLS 20070501

• Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation.

  American journal of physiology. Renal physiology 20070401

• Peroxisome proliferator-activated receptor gamma (PPARgamma) and immunoregulation: enhancement of regulatory T cells through PPARgamma-dependent and -independent mechanisms.

  Journal of immunology (Baltimore, Md. : 1950) 20070401

• Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells.

  International journal of hematology 20070401

• Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation: impact of the suppression of nuclear translocation of ERK1/2.

  Atherosclerosis 20070301

• PPAR-gamma agonist, ciglitazone, increases pigmentation and migration of human melanocytes.

  Experimental dermatology 20070201

• Effect of thiazolidinediones on bile acid transport in rat liver.

  Life sciences 20070130

• PPAR agonists modulate human osteoclast formation and activity in vitro.

  Bone 20070101

• Peroxisome proliferator-activated receptor gamma (PPARgamma) regulates trefoil factor family 2 (TFF2) expression in gastric epithelial cells.

  The international journal of biochemistry & cell biology 20070101

• Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages.

  Immunology and cell biology 20070101

• Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat.

  Reproduction (Cambridge, England) 20070101

• Peroxisome proliferator-activated receptor-gamma agonists cause growth arrest and apoptosis in human ovarian carcinoma cell lines.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101

• Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway.

  The international journal of biochemistry & cell biology 20070101

• Reversal of systemic hypertension-associated cardiac remodeling in chronic pressure overload myocardium by ciglitazone.

  International journal of biological sciences 20070101

• Ciglitazone ameliorates homocysteine-mediated mitochondrial translocation and matrix metalloproteinase-9 activation in endothelial cells by inducing peroxisome proliferator activated receptor-gamma activity.

  Cellular and molecular biology (Noisy-le-Grand, France) 20061231

• 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway.

  Journal of neurochemistry 20061201

• Does the PGC-1/PPARgamma pathway play a role in Com-1/p8 mediated cell growth inhibition in prostate cancer?

  International journal of molecular medicine 20061201

• The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms.

  Journal of immunology (Baltimore, Md. : 1950) 20061015

• Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response.

  Journal of lipid research 20061001

• Cellular and molecular consequences of peroxisome proliferator-activated receptor-gamma activation in ovarian cancer cells.

  Neoplasia (New York, N.Y.) 20061001

• Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells.

  Toxicology and applied pharmacology 20060901

• Peroxisomal proliferator-activated receptor-gamma agonists induce partial reversion of epithelial-mesenchymal transition in anaplastic thyroid cancer cells.

  Endocrinology 20060901

• Role of PPAR-gamma on the pathogenesis and vascular changes in glycerol-induced acute renal failure.

  Pharmacological research 20060901

• PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2.

  Journal of neuroimmunology 20060901

• Rosiglitazone ameliorates cisplatin-induced renal injury in mice.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801

• Troglitazone acutely inhibits protein synthesis in endothelial cells via a novel mechanism involving protein phosphatase 2A-dependent p70 S6 kinase inhibition.

  American journal of physiology. Cell physiology 20060801

• TGF-beta inhibition of CTL re-stimulation requires accessory cells and induces peroxisome-proliferator-activated receptor-gamma (PPAR-gamma).

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060801

• Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.

  Molecular diversity 20060801

• Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells.

  Virology 20060705

• Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2.

  Molecular pharmacology 20060701

• Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line.

  Journal of cellular biochemistry 20060701

• Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.

  Toxicology letters 20060601

• Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation.

  Endocrinology 20060601

• PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells.

  Cancer letters 20060508

• Peroxisome proliferator-activated receptor gamma-independent repression of prostate-specific antigen expression by thiazolidinediones in prostate cancer cells.

  Molecular pharmacology 20060501

• A comparison of thiazolidinedione-induced adipogenesis and myogenesis in stromal-vascular cells from subcutaneous adipose tissue or semitendinosus muscle of postnatal pigs.

  Journal of animal science 20060501

• Differential modulation of cell cycle, apoptosis and PPARgamma2 gene expression by PPARgamma agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells.

  Prostaglandins, leukotrienes, and essential fatty acids 20060501

• Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis.

  Archives of dermatological research 20060401

• Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells.

  Journal of natural products 20060401

• Identification and treatment of aggressive thyroid cancers. Part 2: risk assessment and treatment.

  Oncology (Williston Park, N.Y.) 20060401

• [Effects of peroxisome proliferators-activated receptor gamma agonists on transforming growth factor-beta1 and Smads signal pathway: experiment with rat renal fibroblasts].

  Zhonghua yi xue za zhi 20060321

• Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells.

  Virology 20060315

• Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system.

  Molecular cancer research : MCR 20060301

• Adaptive-outward and maladaptive-inward arterial remodeling measured by intravascular ultrasound in hyperhomocysteinemia and diabetes.

  Journal of cardiovascular pharmacology and therapeutics 20060301

• Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways.

  Biochemical pharmacology 20060227

• The PPARgamma ligand, rosiglitazone, reduces airways hyperresponsiveness in a murine model of allergen-induced inflammation.

  Pulmonary pharmacology & therapeutics 20060101

• CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation.

  International journal of oncology 20060101

• Involvement of PPARgamma in oxidative stress-mediated prostaglandin E(2) production in SZ95 human sebaceous gland cells.

  The Journal of investigative dermatology 20060101

• Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma.

  American journal of nephrology 20060101

• Influence of ciglitazone on A549 cells growth in vitro and in vivo and mechanism.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

• Peroxisome proliferator-activated receptor-gamma is expressed by rat peritoneal mesothelial cells: its potential role in peritoneal cavity local defense.

  American journal of nephrology 20060101

• Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway.

  Cellular signalling 20051201

• LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes.

  Journal of lipid research 20051201

• Effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of retinoic acid-inducible gene-I in endothelial cells stimulated with lipopolysaccharide.

  Prostaglandins & other lipid mediators 20051201

• Effect of peroxisome proliferator-activated receptor-gamma ligand on inflammation of human gallbladder epithelial cells.

  World journal of gastroenterology 20051014

• Ciglitazone inhibits the antigen-induced leukotrienes production independently of PPARgamma in RBL-2H3 mast cells.

  European journal of pharmacology 20051003

• Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta.

  Carcinogenesis 20051001

• Inhibitors of prostaglandin transport and metabolism augment protease-activated receptor-2-mediated increases in prostaglandin E2 levels and smooth muscle relaxation in mouse isolated trachea.

  The Journal of pharmacology and experimental therapeutics 20050901

• Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms.

  Arteriosclerosis, thrombosis, and vascular biology 20050901

• Peroxisome proliferator activated receptor-gamma (PPARgamma) represses thyroid hormone signaling in growth plate chondrocytes.

  Bone 20050901

• Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation.

  Cellular signalling 20050701

• A novel PPAR response element in the murine iNOS promoter.

  Molecular immunology 20050701

• Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model.

  Canadian journal of physiology and pharmacology 20050701

• 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes.

  Experimental & molecular medicine 20050630

• PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis.

  American journal of physiology. Lung cellular and molecular physiology 20050601

• Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages.

  Immunology and cell biology 20050601

• Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.

  Neuropharmacology 20050601

• Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.

  Cancer research 20050515

• Selective activation of PPARgamma in breast, colon, and lung cancer cell lines.

  Molecular and cellular endocrinology 20050512

• Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway.

  Molecular pharmacology 20050501

• Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production.

  American journal of physiology. Cell physiology 20050401

• Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells.

  Molecular pharmacology 20050401

• Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.

  The Journal of biological chemistry 20050318

• PPAR-gamma ligands up-regulate basic fibroblast growth factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts.

  Biochemical and biophysical research communications 20050304

• Ciglitazone-induced lenticular opacities in rats: in vivo and whole lens explant culture evaluation.

  The Journal of pharmacology and experimental therapeutics 20050301

• Ciglitazone induces early cellular proliferation and NF-kappaB transcriptional activity in colon cancer cells through p65 phosphorylation.

  The international journal of biochemistry & cell biology 20050301

• Ciglitazone increases basal cytokine expression in the central nervous system of adult rats.

  Brain research 20050209

• Ciglitizone inhibits cell proliferation in human uterine leiomyoma via activation of store-operated Ca2+ channels.

  American journal of physiology. Cell physiology 20050201

• Epidermal peroxisome proliferator-activated receptor gamma as a target for ultraviolet B radiation.

  The Journal of biological chemistry 20050107

• Influence of physiological conditions on laser damage thresholds for blood, heart, and liver cells.

  Lasers in surgery and medicine 20050101

• Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors.

  Neoplasma 20050101

• A two-dimensional electrophoresis preliminary approach to human hepatocarcinoma differentiation induced by PPAR-agonists.

  Journal of cellular and molecular medicine 20050101

• Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.

  Nuclear receptor 20050101

• Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g.

  Experimental & molecular medicine 20041231

• Nuclear receptor activation and interaction with morphine.

  Journal of neuroimmunology 20041201

• Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells.

  Blood 20041115

• Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression.

  The Journal of biological chemistry 20041112

• Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands.

  Clinical immunology (Orlando, Fla.) 20041101

• Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression.

  Biochemical Society transactions 20041101

• Peroxisome proliferator-activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis.

  Fertility and sterility 20041001

• Implication of peroxisome proliferator-activated receptor gamma and proinflammatory cytokines in gastric carcinogenesis: link to Helicobacter pylori-infection.

  Journal of pharmacological sciences 20041001

• Peroxisome proliferator-activated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells.

  Biochemical and biophysical research communications 20040917

• Ciglitizone and 15d PGJ2 induce apoptosis in Jurkat and Raji cells.

  International immunopharmacology 20040901

• [A study on inflammatory regulation of human gallbladder epithelial cells by PPAR-gamma ligand].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20040901

• Ciglitazone inhibits oxidized-low density lipoprotein induced immune maturation of dendritic cells.

  Journal of cardiovascular pharmacology 20040901

• [Ciglitazone inhibits growth of lung cancer cells A549 in vitro and in vivo: an experimental study].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040901

• Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation.

  The Journal of investigative dermatology 20040801

• Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors.

  Digestive diseases and sciences 20040801

• Mitochondrial respiratory chain dysfunction, a non-receptor-mediated effect of synthetic PPAR-ligands: biochemical and pharmacological implications.

  Biochemical and biophysical research communications 20040702

• Growth hormone inhibits apoptosis in human colonic cancer cell lines: antagonistic effects of peroxisome proliferator activated receptor-gamma ligands.

  Endocrinology 20040701

• Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines.

  Free radical biology & medicine 20040701

• 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process.

  Journal of immunology (Baltimore, Md. : 1950) 20040615

• PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase.

  Circulation research 20040611

• The synthetic ligand of peroxisome proliferator-activated receptor-gamma ciglitazone affects human glioblastoma cell lines.

  The Journal of pharmacology and experimental therapeutics 20040601

• Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists.

  Kidney international 20040601

• PPARgamma inhibits GH synthesis and secretion and increases apoptosis of pituitary GH-secreting adenomas.

  European journal of endocrinology 20040601

• 15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts.

  The Journal of biological chemistry 20040521

• 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes.

  The Journal of biological chemistry 20040521

• Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.

  Bioorganic & medicinal chemistry letters 20040517

• Peroxisome proliferator-activated receptor gamma is expressed in airways and inhibits features of airway remodeling in a mouse asthma model.

  The Journal of allergy and clinical immunology 20040501

• Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression.

  Chest 20040501

• Peroxisome proliferator ameliorates endocardial endothelial and muscarinic dysfunction in spontaneously hypertensive rats.

  Antioxidants & redox signaling 20040401

• Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones.

  Thrombosis and haemostasis 20040401

• Proteome analysis of adipogenesis.

  Proteomics 20040401

• Up-regulation of p21 gene expression by peroxisome proliferator-activated receptor gamma in human lung carcinoma cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040315

• Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients.

  Journal of leukocyte biology 20040301

• Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells.

  Gut 20040301

• [The effects of nuclear factor kappa B decoy oligodeoxynucleotides on ciglitazone-induced differentiation of lung cancer cells A549].

  Zhonghua nei ke za zhi 20040301

• Src kinase-dependent epidermal growth factor receptor transactivation in PPARgamma ligand-induced suppression of Porphyromonas gingivalis interference with salivary mucin synthesis.

  IUBMB life 20040301

• PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation.

  Circulation research 20040220

• Interferon regulatory factor-1 mediates PPARgamma-induced apoptosis in vascular smooth muscle cells.

  Arteriosclerosis, thrombosis, and vascular biology 20040201

• 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells.

  The Tohoku journal of experimental medicine 20040201

• Sensing environmental lipids by dendritic cell modulates its function.

  Journal of immunology (Baltimore, Md. : 1950) 20040101

• Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma.

  The American journal of pathology 20040101

• Role of epidermal growth factor receptor transactivation in PPAR gamma-dependent suppression of Helicobacter pylori interference with gastric mucin synthesis.

  Inflammopharmacology 20040101

• Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways.

  Journal of immunology (Baltimore, Md. : 1950) 20031215

• Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201

• 15-deoxy-delta12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms.

  Journal of neurochemistry 20031101

• Inhibition of interleukin-4 production in CD4+ T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor.

  Molecular pharmacology 20031101

• Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta.

  Journal of cellular biochemistry 20031101

• Comparative studies of resistin expression and phylogenomics in human and mouse.

  Biochemical and biophysical research communications 20031024

• Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma.

  Archives of biochemistry and biophysics 20031015

• The effect of PPARgamma ligands on the proliferation and apoptosis of human melanoma cells.

  Melanoma research 20031001

• Inhibition of IgE-production by peroxisome proliferator-activated receptor ligands.

  The Journal of investigative dermatology 20031001

• Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.

  Circulation research 20030822

• Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary.

  Biology of reproduction 20030801

• Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20030715

• [Apoptosis of human lung cancer cells induced by activated peroxisome proliferator-activated receptor-gamma and its mechanism].

  Zhonghua yi xue za zhi 20030710

• PPARgamma ligand attenuates PDGF-induced mesangial cell proliferation: role of MAP kinase.

  Kidney international 20030701

• Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells.

  Cancer research 20030701

• 15-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide.

  Prostaglandins & other lipid mediators 20030701

• [Effects of peroxisome proliferator-activated receptor-gamma agonist on Fas-mediated apoptosis in HT-29 cells].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20030701

• Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells.

  Oncogene 20030619

• Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability.

  Journal of neuroscience research 20030615

• Inhibition of cyclooxygenase-2 and activation of peroxisome proliferator-activated receptor-gamma synergistically induces apoptosis and inhibits growth of human breast cancer cells.

  International journal of molecular medicine 20030601

• Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.

  The Biochemical journal 20030515

• Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis.

  Journal of leukocyte biology 20030501

• Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma.

  Cancer research 20030315

• 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism.

  Biochemical and biophysical research communications 20030307

• Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy.

  Journal of immunology (Baltimore, Md. : 1950) 20030301

• Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.

  Cancer research 20030301

• Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells.

  Fertility and sterility 20030301

• The antiproliferative effects of PPARgamma ligands in normal human mammary epithelial cells.

  Breast cancer research and treatment 20030301

• The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications.

  Gene 20030213

• Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors.

  Journal of immunology (Baltimore, Md. : 1950) 20030115

• Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20030101

• Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells.

  Cellular and molecular life sciences : CMLS 20030101

• Thiazolidinedione inhibition of peritoneal inflammation.

  Gynecologic and obstetric investigation 20030101

• Negative growth effects of ciglitazone on kidney interstitial fibroblasts: role of PPAR-gamma.

  Kidney & blood pressure research 20030101

• Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury.

  American journal of nephrology 20030101

• Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells.

  Journal of immunology (Baltimore, Md. : 1950) 20021215

• Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents.

  Prostaglandins, leukotrienes, and essential fatty acids 20021201

• Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth.

  Molecular pharmacology 20021101

• Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.

  Hypertension (Dallas, Tex. : 1979) 20021101

• [Discovery and development of a new insulin sensitizing agent, pioglitazone].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021101

• Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells.

  American journal of physiology. Endocrinology and metabolism 20021001

• Studies on non-thiazolidinedione antidiabetic agents. 1. Discovery of novel oxyiminoacetic acid derivatives.

  Chemical & pharmaceutical bulletin 20021001

• Characterization of sucrose-induced changes in cardiac phenotype.

  Pflugers Archiv : European journal of physiology 20021001

• Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells.

  Biochemical and biophysical research communications 20020920

• Thiazolidinediones as a novel class of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.

  Archives of biochemistry and biophysics 20020915

• Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects.

  Journal of acquired immune deficiency syndromes (1999) 20020901

• Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.

  The Journal of biological chemistry 20020830

• MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species.

  The Journal of biological chemistry 20020816

• Ciglitazone inhibits plasmin-induced proinflammatory monocyte activation via modulation of p38 MAP kinase activity.

  Thrombosis and haemostasis 20020801

• Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.

  Experimental cell research 20020715

• Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39.

  Biochemical and biophysical research communications 20020712

• Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701

• Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.

  Brain research 20020621

• Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.

  Journal of neurochemistry 20020601

• Suppression of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide by peroxisome proliferator-activated receptor gamma activation.

  IUBMB life 20020601

• PPAR activators inhibit endothelial cell migration by targeting Akt.

  Biochemical and biophysical research communications 20020524

• Peroxisome proliferator-activated receptor gamma agonists inhibit HIV-1 replication in macrophages by transcriptional and post-transcriptional effects.

  The Journal of biological chemistry 20020510

• Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020501

• Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer.

  Life sciences 20020419

• 15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death.

  Kidney international 20020401

• Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020401

• Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation.

  Genes and immunity 20020401

• Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities.

  Journal of medicinal chemistry 20020328

• Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors.

  Journal of immunology (Baltimore, Md. : 1950) 20020315

• Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma.

  Journal of immunology (Baltimore, Md. : 1950) 20020315

• Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.

  Arthritis and rheumatism 20020201

• [Thiazolidinediones and PPARgamma system in repair of liver damage].

  Recenti progressi in medicina 20020101

• Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells.

  International journal of gastrointestinal cancer 20020101

• 15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells.

  Prostaglandins & other lipid mediators 20011201

• Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPAR-gamma-independent manner.

  Prostaglandins & other lipid mediators 20011001

• Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.

  Prostaglandins, leukotrienes, and essential fatty acids 20011001

• trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes.

  Biochemical and biophysical research communications 20010921

• Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells.

  Carcinogenesis 20010901

• TZDs inhibit vascular smooth muscle cell growth independently of the cyclin kinase inhibitors p21 and p27.

  American journal of physiology. Endocrinology and metabolism 20010801

• Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin.

  Journal of cell science 20010801

• Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region.

  The Biochemical journal 20010715

• Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.

  European journal of pharmacology 20010713

• Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements.

  Biochemical and biophysical research communications 20010622

• Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation.

  American journal of respiratory cell and molecular biology 20010601

• Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines.

  Hepatology (Baltimore, Md.) 20010501

• Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300.

  The Journal of biological chemistry 20010413

• The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.

  European journal of immunology 20010401

• A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma.

  Biochemical and biophysical research communications 20010216

• Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010201

• Synergistic potentiation of thiazolidinedione-induced ST 13 preadipocyte differentiation by RAR synergists.

  Biochemical and biophysical research communications 20010126

• Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones.

  European journal of medicinal chemistry 20010101

• Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.

  FEBS letters 20001027

• Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line.

  British journal of pharmacology 20001001

• PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate.

  Biochemical and biophysical research communications 20000607

• Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo.

  The Journal of biological chemistry 19990326

• N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.

  Journal of medicinal chemistry 19981203

• A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.

  Cell 19951201

• Effects of ciglitazone on blood pressure and intracellular calcium metabolism.

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