749234-11-5 | Dmat

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$48.00	$34.00
5mg	≥98%	in stock	$207.00	$145.00
10mg	≥98%	in stock	$225.00	$158.00
50mg		in stock	$545.00	$382.00

Description

• Catalog Number: AB72186
• Chemical Name: Dmat
• CAS Number: 749234-11-5
• Molecular Formula: C9H7Br4N3
• Molecular Weight: 476.7880
• MDL Number: MFCD08705322
• SMILES: CN(c1[nH]c2c(n1)c(Br)c(c(c2Br)Br)Br)C

Computed Properties

• Complexity: 265
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 4.7

Literature

• Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.

  Proceedings of the National Academy of Sciences of the United States of America 20160906

• Casein kinase 2α regulates multidrug resistance-associated protein 1 function via phosphorylation of Thr249.

  Molecular pharmacology 20120901

• Modified tetrahalogenated benzimidazoles with CK2 inhibitory activity are active against human prostate cancer cells LNCaP in vitro.

  Bioorganic & medicinal chemistry 20120715

• Protein kinase CK2 is implicated in early steps of the differentiation of pre-adipocytes into adipocytes.

  Molecular and cellular biochemistry 20120601

• Structural determinants for rCNT2 sorting to the plasma membrane of polarized and non-polarized cells.

  The Biochemical journal 20120315

• Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7.

  Science signaling 20120207

• Characterization of ATM and DNA-PK wild-type and mutant cell lines upon DSB induction in the presence and absence of CK2 inhibitors.

  International journal of oncology 20120201

• Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells.

  Cancer letters 20120201

• A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

  Toxicology and applied pharmacology 20120115

• CK2α and CK2α' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives.

  European journal of medicinal chemistry 20120101

• Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer cells.

  International journal of biological sciences 20120101

• GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis.

  Nature chemical biology 20111201

• Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2.

  Journal of proteome research 20111104

• Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production.

  Journal of cellular biochemistry 20111101

• Down-regulation of CK2 activity results in a decrease in the level of cdc25C phosphatase in different prostate cancer cell lines.

  Molecular and cellular biochemistry 20111001

• Adiponectin receptor 1 interacts with both subunits of protein kinase CK2.

  Molecular and cellular biochemistry 20111001

• CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.

  DNA repair 20110905

• Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT.

  International journal of oncology 20110801

• The cytosolic protein kinase CK2 phosphorylates cardiac calsequestrin in intact cells.

  Molecular and cellular biochemistry 20110701

• Protein kinase CK2/PTEN pathway plays a key role in platelet-activating factor-mediated murine anaphylactic shock.

  Journal of immunology (Baltimore, Md. : 1950) 20110601

• Kinase inhibitors modulate huntingtin cell localization and toxicity.

  Nature chemical biology 20110529

• IL-6 stabilizes Twist and enhances tumor cell motility in head and neck cancer cells through activation of casein kinase 2.

  PloS one 20110101

• Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation.

  PloS one 20110101

• Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.

  Molecular endocrinology (Baltimore, Md.) 20100701

• Bovine herpesvirus-1 US3 protein kinase: critical residues and involvement in the phosphorylation of VP22.

  The Journal of general virology 20100501

• Phosphorylation of phosducin-like protein BDM-1 by protein kinase 2 (CK2) is required for virulence and G beta subunit stability in the fungal plant pathogen Cryphonectria parasitica.

  Molecular microbiology 20100501

• Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro.

  Cell and tissue research 20100501

• Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2.

  The Journal of biological chemistry 20100409

• Halogenated imidazole derivatives block RNA polymerase II elongation along mitogen inducible genes.

  BMC molecular biology 20100101

• Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt.

  PloS one 20100101

• Major tegument protein VP8 of bovine herpesvirus 1 is phosphorylated by viral US3 and cellular CK2 protein kinases.

  The Journal of general virology 20091201

• Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.

  International journal of oncology 20091101

• Selectivity analysis of protein kinase CK2 inhibitors DMAT, TBB and resorufin in cisplatin-induced stress responses.

  International journal of oncology 20091101

• Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells.

  Cancer research 20091015

• Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling.

  Cellular signalling 20090601

• DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks.

  Oncology reports 20090601

• Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation.

  PLoS pathogens 20090501

• Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

  The Journal of biological chemistry 20090410

• Erythrocytic casein kinase II regulates cytoadherence of Plasmodium falciparum-infected red blood cells.

  The Journal of biological chemistry 20090306

• WAVE2 is regulated by multiple phosphorylation events within its VCA domain.

  Cell motility and the cytoskeleton 20090101

• Peptide biosensors for the electrochemical measurement of protein kinase activity.

  Analytical chemistry 20081215

• Casein kinase 2 regulates the active uptake of the organic osmolyte taurine in NIH3T3 mouse fibroblasts.

  Pflugers Archiv : European journal of physiology 20081101

• The selectivity of inhibitors of protein kinase CK2: an update.

  The Biochemical journal 20081101

• New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole.

  Molecular and cellular biochemistry 20080901

• Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity.

  Current neurovascular research 20080801

• An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.

  Molecular & cellular proteomics : MCP 20080601

• Regulation of hepatitis C virion production via phosphorylation of the NS5A protein.

  PLoS pathogens 20080301

• Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells.

  Journal of biochemical and molecular toxicology 20080201

• CK2beta gene silencing increases cell susceptibility to influenza A virus infection resulting in accelerated virus entry and higher viral protein content.

  Journal of molecular signaling 20080101

• Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.

  Cancer letters 20071028

• Induction of alkaline phosphatase activity by L-ascorbic acid in human osteoblastic cells: a potential role for CK2 and Ikaros.

  Nutrition (Burbank, Los Angeles County, Calif.) 20071001

• Inhibition of protein kinase CK2 leads to a modulation of androgen receptor dependent transcription in prostate cancer cells.

  The Prostate 20070201

• Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2.

  Leukemia 20070101

• Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.

  Chemistry & biology 20051101

• Development and exploitation of CK2 inhibitors.

  Molecular and cellular biochemistry 20050601

• Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.

  Journal of medicinal chemistry 20041202

• 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.

  Biochemical and biophysical research communications 20040903

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419