75330-75-5 | Lovastatin

Packsize	Purity	Availability	Price	Discounted Price
10mg	98%	in stock	$14.00	$10.00
50mg	98%	in stock	$37.00	$26.00
1g	98%	in stock	$76.00	$53.00
5g	98%	in stock	$78.00	$55.00
25g	98%	in stock	$93.00	$65.00
100g	98%	in stock	$112.00	$79.00

Description

• Catalog Number: AC48900
• Chemical Name: Lovastatin
• CAS Number: 75330-75-5
• Molecular Formula: C24H36O5
• Molecular Weight: 404.5396
• MDL Number: MFCD00072164
• SMILES: CC[C@@H](C(=O)O[C@H]1C[C@@H](C)C=C2[C@H]1[C@@H](CC[C@@H]1C[C@@H](O)CC(=O)O1)[C@H](C=C2)C)C

Computed Properties

• Complexity: 666
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 4.3

Literature

• Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway.

  Chemico-biological interactions 20180625

• Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages.

  International journal of molecular medicine 20180201

• Rac1-mediated cardiac damage causes diastolic dysfunction in a mouse model of subacute doxorubicin-induced cardiotoxicity.

  Archives of toxicology 20180101

• Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway.

  Toxicology and applied pharmacology 20160801

• Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway.

  Oncotarget 20160301

• Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cells.

  Toxicology and applied pharmacology 20160201

• Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

  Chemical research in toxicology 20150518

• Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway.

  PloS one 20140101

• Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.

  Journal of biomedical science 20140101

• Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.

  PloS one 20140101

• Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).

  Toxicological sciences : an official journal of the Society of Toxicology 20131201

• A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

  Toxicological sciences : an official journal of the Society of Toxicology 20131101

• Hexavalent chromium-induced alteration of proteomic landscape in human skin fibroblast cells.

  Journal of proteome research 20130705

• ATP-dependent transport of statins by human and rat MRP2/Mrp2.

  Toxicology and applied pharmacology 20130601

• Dietary Monascus adlay supplements facilitate suppression of cigarette smoke-induced pulmonary endoplasmic reticulum stress, autophagy, apoptosis and emphysema-related PLGF in the rat.

  Food chemistry 20130115

• Statin use and the risk of Clostridium difficile in academic medical centres.

  Gut 20121101

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• Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice.

  Brain research 20121022

• [Histological character of intimal hyperplasia post jugular vein grafts and the protective effect of lovastatin].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20121018

• Anti-cancer characteristics of mevinolin against three different solid tumor cell lines was not solely p53-dependent.

  Journal of enzyme inhibition and medicinal chemistry 20121001

• Development and validation of a simple and fast HPLC method for determination of lovastatin, pravastatin and simvastatin.

  Journal of chromatographic science 20121001

• Combined blockade of signalling pathways shows marked anti-tumour potential in phaeochromocytoma cell lines.

  Journal of molecular endocrinology 20121001

• Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20121001

• Teratogenic risk of statins in pregnancy.

  The Annals of pharmacotherapy 20121001

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  European journal of pharmacology 20120905

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• Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis.

  The American journal of pathology 20120901

• A statin-regulated microRNA represses human c-Myc expression and function.

  EMBO molecular medicine 20120901

• Statins and new-onset diabetes: a retrospective longitudinal cohort study.

  Clinical therapeutics 20120901

• Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism.

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• Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption.

  Molecular pharmacology 20120801

• Short-term high-dose effect of lovastatin on thrombolysis by rt-PA in a human whole-blood in vitro clot model.

  Current neurovascular research 20120801

• Statins and downstream inhibitors of the isoprenylation pathway increase type 2 iodothyronine deiodinase activity.

  Endocrinology 20120801

• Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent.

  PLoS biology 20120801

• Development of monacolin K-enriched ganghwayakssuk (Artemisia princeps Pamp.) by fermentation with Monascus pilosus.

  Journal of microbiology and biotechnology 20120701

• Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats.

  Acta cirurgica brasileira 20120701

• Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats.

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  Zhonghua yi xue za zhi 20120619

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  The European journal of health economics : HEPAC : health economics in prevention and care 20120601

• Impact of CYP2D6 polymorphisms on the pharmacokinetics of lovastatin in Chinese subjects.

  European journal of clinical pharmacology 20120601

• Molecular pathways regulating macrophage polarization: implications for atherosclerosis.

  Current atherosclerosis reports 20120601

• Lovastatin alters TGF-β-induced epithelial-mesenchymal transition in porcine lens epithelial cells.

  Current eye research 20120601

• The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes.

  Molecular nutrition & food research 20120601

• Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

  Journal of medicinal chemistry 20120524

• The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity.

  Toxicology and applied pharmacology 20120515

• Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin/kexin type 9.

  Journal of the American College of Cardiology 20120508

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  Nutrition, metabolism, and cardiovascular diseases : NMCD 20120501

• Fibroblasts--a key host cell type in tumor initiation, progression, and metastasis.

  Upsala journal of medical sciences 20120501

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  Critical reviews in toxicology 20120501

• Prediction of drug-target interactions and drug repositioning via network-based inference.

  PLoS computational biology 20120501

• Lovastatin regulates brain spontaneous low-frequency brain activity in neurofibromatosis type 1.

  Neuroscience letters 20120425

• Molecular cloning of mevalonate pathway genes from Taraxacum brevicorniculatum and functional characterisation of the key enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

  Molecular biology reports 20120401

• Simultaneous determination of simvastatin, lovastatin and niacin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.

  Biomedical chromatography : BMC 20120401

• Uniform mesoporous carbon as a carrier for poorly water soluble drug and its cytotoxicity study.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120401

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  FEMS microbiology letters 20120401

• The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies.

  Langenbeck's archives of surgery 20120401

• Effect of lovastatin therapy and withdrawal on serum uric acid level in people with type 2 diabetic nephropathy.

  Nucleosides, nucleotides & nucleic acids 20120401

• The Effects of Combined Treatment with an HMG-CoA Reductase Inhibitor and PPARγ Agonist on the Activation of Rat Pancreatic Stellate Cells.

  Gut and liver 20120401

• Spectrofluorimetric determination of aliskiren in tablets and spiked human plasma through derivatization with dansyl chloride.

  Journal of fluorescence 20120301

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  Acta dermato-venereologica 20120301

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  Laboratory animal research 20120301

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  The Indian journal of medical research 20120301

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  Experimental & molecular medicine 20120227

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  Archives of medical science : AMS 20120227

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  British journal of cancer 20120214

• PPARγ contributes to PKM2 and HK2 expression in fatty liver.

  Nature communications 20120214

• Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.

  Nature cell biology 20120212

• Proteomics and bioinformatics analysis of lovastatin-induced differentiation in ARO cells.

  Journal of proteomics 20120202

• Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth.

  Cancer 20120201

• Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis.

  QJM : monthly journal of the Association of Physicians 20120201

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  Computers in biology and medicine 20120201

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  Acta orthopaedica 20120201

• Selecting an invertebrate model host for the study of fungal pathogenesis.

  PLoS pathogens 20120201

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• Acute rhabdomyolysis caused by combination therapy with atorvastatin and warfarin.

  British journal of hospital medicine (London, England : 2005) 20120201

• Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin.

  World journal of gastroenterology 20120114

• Trillin, a steroidal saponin isolated from the rhizomes of Dioscorea nipponica, exerts protective effects against hyperlipidemia and oxidative stress.

  Journal of ethnopharmacology 20120106

• Fast screening of lovastatin in red yeast rice products by flow injection tandem mass spectrometry.

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  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20120101

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  International journal of vascular medicine 20120101

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• The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects.

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  Indian journal of pharmacology 20120101

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  Oxidative medicine and cellular longevity 20120101

• Elucidation of the Rotavirus NSP4-Caveolin-1 and -Cholesterol Interactions Using Synthetic Peptides.

  Journal of amino acids 20120101

• Screening of medicinal higher Basidiomycetes mushrooms from Turkey for lovastatin production.

  International journal of medicinal mushrooms 20120101

• Abnormal barrier function in the pathogenesis of ichthyosis: therapeutic implications for lipid metabolic disorders.

  Clinics in dermatology 20120101

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  Journal of biomedicine & biotechnology 20120101

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  Evidence-based complementary and alternative medicine : eCAM 20120101

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  BMJ open 20120101

• Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders.

  Neural plasticity 20120101

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• Deciphering the molecular functions of sterols in cellulose biosynthesis.

  Frontiers in plant science 20120101

• Epigenetics modifications and therapeutic prospects in human thyroid cancer.

  Frontiers in endocrinology 20120101

• Optimization of the Nutritional Parameters for Enhanced Production of B. subtilis SPB1 Biosurfactant in Submerged Culture Using Response Surface Methodology.

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• PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials.

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• Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi.

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• Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway.

  PloS one 20120101

• The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis.

  PloS one 20120101

• Statistical optimization of process variables for antibiotic activity of Xenorhabdus bovienii.

  PloS one 20120101

• Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation.

  PloS one 20120101

• Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus.

  PloS one 20120101

• Phylogenomic and domain analysis of iterative polyketide synthases in Aspergillus species.

  Evolutionary bioinformatics online 20120101

• Effect of hydroalcoholic extract of Hypericum perforatum on selected traditional and novel biochemical factors of cardiovascular diseases and atherosclerotic lesions in hypercholesterolemic rabbits: A comparison between the extract and lovastatin.

  Journal of pharmacy & bioallied sciences 20120101

• Effects of tocotrienol and lovastatin combination on osteoblast and osteoclast activity in estrogen-deficient osteoporosis.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• A survey of the FDA's AERS database regarding muscle and tendon adverse events linked to the statin drug class.

  PloS one 20120101

• Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy.

  PloS one 20120101

• Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells.

  PloS one 20120101

• Transgelin 2 participates in lovastatin-induced anti-angiogenic effects in endothelial cells through a phosphorylated myosin light chain-related mechanism.

  PloS one 20120101

• Regulatory cross talk and microbial induction of fungal secondary metabolite gene clusters.

  Methods in enzymology 20120101

• Lovastatin production by Aspergillus terreus using agro-biomass as substrate in solid state fermentation.

  Journal of biomedicine & biotechnology 20120101

• Quantitative proteomic analysis revealed lovastatin-induced perturbation of cellular pathways in HL-60 cells.

  Journal of proteome research 20111202

• CKD-MBD after kidney transplantation.

  Pediatric nephrology (Berlin, Germany) 20111201

• Association of lower total bilirubin level with statin usage: the United States National Health and Nutrition Examination Survey 1999-2008.

  Atherosclerosis 20111201

• Therapeutics for childhood neurofibromatosis type 1 and type 2.

  Current treatment options in neurology 20111201

• Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol.

  Journal of neurochemistry 20111201

• Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway.

  Biochemical pharmacology 20111201

• Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy.

  Apoptosis : an international journal on programmed cell death 20111201

• Preparation and characterization of a lovastatin-loaded protein-free nanostructured lipid carrier resembling high-density lipoprotein and evaluation of its targeting to foam cells.

  AAPS PharmSciTech 20111201

• Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism.

  Molecular nutrition & food research 20111201

• Valosin-containing protein and neurofibromin interact to regulate dendritic spine density.

  The Journal of clinical investigation 20111201

• Fatal rhabdomyolysis in a patient with liver cirrhosis after switching from simvastatin to fluvastatin.

  Journal of Korean medical science 20111201

• Floral odor bouquet loses its ant repellent properties after inhibition of terpene biosynthesis.

  Journal of chemical ecology 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.

  Oncotarget 20111201

• Recent advances in mechanisms and treatments of airway remodeling in asthma: a message from the bench side to the clinic.

  The Korean journal of internal medicine 20111201

• Prediction of drug combinations by integrating molecular and pharmacological data.

  PLoS computational biology 20111201

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  Lakartidningen 20111201

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  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 20111201

• Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents.

  Bioorganic & medicinal chemistry letters 20111115

• Phylogeny of Penicillium and the segregation of Trichocomaceae into three families.

  Studies in mycology 20111115

• Cost-effectiveness of the use of low- and high-potency statins in people at low cardiovascular risk.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20111108

• Pathogenesis-based therapy reverses cutaneous abnormalities in an inherited disorder of distal cholesterol metabolism.

  The Journal of investigative dermatology 20111101

• Fluvastatin modulates renal water reabsorption in vivo through increased AQP2 availability at the apical plasma membrane of collecting duct cells.

  Pflugers Archiv : European journal of physiology 20111101

• Statins inhibit iNOS-mediated microbicidal potential of activated monocyte-derived dendritic cells by an IFN-β-dependent mechanism.

  European journal of immunology 20111101

• A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.

  Journal of lipid research 20111101

• Efficient bioconversion of compactin to pravastatin by the quinoline-degrading microorganism Pseudonocardia carboxydivorans isolated from petroleum-contaminated soil.

  Bioresource technology 20111101

• Statin effects on regulatory and proinflammatory factors in chronic idiopathic urticaria.

  Clinical and experimental immunology 20111101

• A cost-benefit analysis of lipid standardization in the United States.

  Preventing chronic disease 20111101

• Modifiers of symptomatic embolic risk in infective endocarditis.

  Mayo Clinic proceedings 20111101

• Preparation of lovastatin matrix sustained-release pellets by extrusion-spheronization combined with microcrystal dispersion technique.

  Archives of pharmacal research 20111101

• Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I.

  Human molecular genetics 20111015

• Highly efficient release of lovastatin from poly(lactic-co-glycolic acid) nanoparticles enhances bone repair in rats.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20111001

• Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis.

  Lipids 20111001

• Thalidomide, dexamethasone and lovastatin with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma.

  Annals of hematology 20111001

• Induction of a high-yield lovastatin mutant of Aspergillus terreus by ¹²C⁶⁺ heavy-ion beam irradiation and the influence of culture conditions on lovastatin production under submerged fermentation.

  Applied biochemistry and biotechnology 20111001

• Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts.

  Biochimica et biophysica acta 20111001

• The cytostatic effects of lovastatin on ACC-MESO-1 cells.

  The Journal of surgical research 20111001

• Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent.

  European journal of medicinal chemistry 20111001

• Antioxidant effect of red mould rice in hypercholesterolemic Wistar male rats.

  Cell biochemistry and function 20111001

• Lovastatin as treatment for neurocognitive deficits in neurofibromatosis type 1: phase I study.

  Pediatric neurology 20111001

• Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study.

  Croatian medical journal 20111001

• [Rhabdomyolysis related to statin and seizures: report of 3 cases].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20111001

• [Study on effect of berberine on modulating lipid and CPT I A gene expression].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001

• Are patients undergoing treatment of hyperlipidaemia with statins the best candidates for early cardiac rehabilitation?

  Archives of medical science : AMS 20111001

• Osteoprotective effect of Monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis.

  Journal of agricultural and food chemistry 20110914

• The 2',4',6'-trihydroxyacetophenone isolated from Myrcia multiflora has antiobesity and mixed hypolipidemic effects with the reduction of lipid intestinal absorption.

  Planta medica 20110901

• Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders.

  Pharmacological research 20110901

• Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice.

  Cardiovascular research 20110901

• AAPS workshop report: strategies to address therapeutic protein-drug interactions during clinical development.

  The AAPS journal 20110901

• Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib.

  Journal of cellular physiology 20110901

• Xuezhikang, extract of red yeast rice, inhibited tissue factor and hypercoagulable state through suppressing nicotinamide adenine dinucleotide phosphate oxidase and extracellular signal-regulated kinase activation.

  Journal of cardiovascular pharmacology 20110901

• Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients.

  Annals of neurology 20110901

• Evaluation of a pharmacist-managed amiodarone monitoring program.

  Journal of managed care pharmacy : JMCP 20110901

• Genomic and proteomic analyses of the fungus Arthrobotrys oligospora provide insights into nematode-trap formation.

  PLoS pathogens 20110901

• The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.

  PLoS genetics 20110901

• Neurotoxic effect of statins on mouse neuroblastoma NB2a cell line.

  European review for medical and pharmacological sciences 20110901

• [Clinical study on the treatment of abnormal blood lipids complicated with carotid atherosclerosis with lipid-reducing red rice minute powder: a randomized controlled trial].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110901

• Inhibition of endothelial adhesion molecule expression by Monascus purpureus-fermented rice metabolites, monacolin K, ankaflavin, and monascin.

  Journal of the science of food and agriculture 20110815

• Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.

  The Biochemical journal 20110815

• Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs.

  The pharmacogenomics journal 20110801

• Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle.

  Cell death and differentiation 20110801

• Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.

  Environmental and molecular mutagenesis 20110801

• Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells.

  Endocrine-related cancer 20110801

• Parkinson's disease mouse models in translational research.

  Mammalian genome : official journal of the International Mammalian Genome Society 20110801

• Disturbed subjective sleep characteristics in adult patients with long-standing type 1 diabetes mellitus.

  Diabetologia 20110801

• Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation.

  Endocrinology 20110801

• Juvenile toxicity assessment of open-acid lovastatin in rats.

  Birth defects research. Part B, Developmental and reproductive toxicology 20110801

• Function of MRP1/ABCC1 is not dependent on cholesterol or cholesterol-stabilized lipid rafts.

  The Biochemical journal 20110801

• SR-PSOX at sites predisposed to atherosclerotic lesion formation mediates monocyte-endothelial cell adhesion.

  Atherosclerosis 20110801

• Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity.

  Cell death & disease 20110801

• Anti-apoptotic machinery protects the necrotrophic fungus Botrytis cinerea from host-induced apoptotic-like cell death during plant infection.

  PLoS pathogens 20110801

• Diallyl disulphide and lovastatin: effects on energy and protein utilisation in, as well as methane emission from, sheep.

  Archives of animal nutrition 20110801

• Comparison of different extraction methods for the determination of statin drugs in wastewater and river water by HPLC/Q-TOF-MS.

  Talanta 20110715

• Rhadbomyolysis associated with co-administration of danazol and lovastatin.

  British journal of clinical pharmacology 20110701

• The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency.

  Pediatric research 20110701

• Use of transporter knockdown Caco-2 cells to investigate the in vitro efflux of statin drugs.

  Drug metabolism and disposition: the biological fate of chemicals 20110701

• Antitumor effects of the combination of cholesterol reducing drugs.

  Oncology reports 20110701

• Ruminal methane inhibition potential of various pure compounds in comparison with garlic oil as determined with a rumen simulation technique (Rusitec).

  The British journal of nutrition 20110701

• Is there a treatment advantage when paclitaxel and lovastatin are combined to dose anaplastic thyroid carcinoma cell lines?

  Thyroid : official journal of the American Thyroid Association 20110701

• Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells.

  Biochemical and biophysical research communications 20110701

• Trichothecenes: from simple to complex mycotoxins.

  Toxins 20110701

• Antioxidant effects of Citrus aurantifolia (Christm) juice and peel extract on LDL oxidation.

  Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110701

• New species in Aspergillus section Terrei.

  Studies in mycology 20110630

• [Pharmaco-economic optimization of cholesterol-lowering treatment with statins].

  Medicina clinica 20110625

• Polysorbates as novel lipid-modulating candidates for reducing serum total cholesterol and low-density lipoprotein levels in hyperlipidemic C57BL/6J mice and rats.

  European journal of pharmacology 20110625

• Statins and prostate cancer diagnosis and grade in a veterans population.

  Journal of the National Cancer Institute 20110608

• Lovastatin inhibits thrombospondin-1-induced smooth muscle cell chemotaxis.

  The Journal of surgical research 20110601

• Mode of action of parasporin-4, a cytocidal protein from Bacillus thuringiensis.

  Biochimica et biophysica acta 20110601

• A clone-based transcriptomics approach for the identification of genes relevant for itaconic acid production in Aspergillus.

  Fungal genetics and biology : FG & B 20110601

• Role of intestinal cytochrome P450 (P450) in modulating the bioavailability of oral lovastatin: insights from studies on the intestinal epithelium-specific P450 reductase knockout mouse.

  Drug metabolism and disposition: the biological fate of chemicals 20110601

• Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA.

  Journal of the American Chemical Society 20110601

• Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniae.

  Bioorganic & medicinal chemistry 20110601

• Niacin extended-release therapy in phase III clinical trials is associated with relatively low rates of drug discontinuation due to flushing and treatment-related adverse events: a pooled analysis.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20110601

• Lovastatin causes diminished PSA secretion by inhibiting AR expression and function in LNCaP prostate cancer cells.

  Urology 20110601

• Antihyperlipidemic activities of Pleurotus ferulae on biochemical and histological function in hypercholesterolemic rats.

  Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110601

• [Experimental studies on blood lipid regulating effects of shuanghua granules].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

• 2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells.

  Proceedings of the Japan Academy. Series B, Physical and biological sciences 20110511

• Cytotoxic effect of different statins and thiazolidinediones on malignant glioma cells.

  Cancer chemotherapy and pharmacology 20110501

• Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages.

  The Journal of veterinary medical science 20110501

• Development of natural anti-tumor drugs by microorganisms.

  Journal of bioscience and bioengineering 20110501

• Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate.

  The Journal of pharmacology and experimental therapeutics 20110501

• Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells.

  Cancer letters 20110501

• Adherence to single-pill combination versus multiple-pill combination lipid-modifying therapy among patients with mixed dyslipidemia in a managed care population.

  Current medical research and opinion 20110501

• Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita.

  The Journal of investigative dermatology 20110501

• Decrease in dipeptidyl peptidase IV activity is linked to the efficacy of differentiating compounds in follicular thyroid carcinoma cell lines.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110501

• Native low-density lipoprotein-dependent interleukin-8 production through pertussis toxin-sensitive G-protein coupled receptors and hydrogen peroxide generation contributes to migration of human aortic smooth muscle cells.

  Yonsei medical journal 20110501

• Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.

  Experimental biology and medicine (Maywood, N.J.) 20110501

• Effects of ezetimibe added to ongoing statin therapy on C-reactive protein levels in hypercholesterolemic patients.

  Korean circulation journal 20110501

• Isoprenoid biosynthetic pathway inhibition disrupts monoclonal protein secretion and induces the unfolded protein response pathway in multiple myeloma cells.

  Leukemia research 20110401

• Lovastatin promotes redifferentiation of human nucleus pulposus cells during expansion in monolayer culture.

  Artificial organs 20110401

• The effect of lovastatin on oxidative stress and antioxidant enzymes in hydrogen peroxide intoxicated rat.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110401

• Lactone form 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) stimulate the osteoblastic differentiation of mouse periodontal ligament cells via the ERK pathway.

  Journal of periodontal research 20110401

• Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.

  The Journal of biological chemistry 20110401

• Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin.

  The Journal of pharmacology and experimental therapeutics 20110401

• Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b.

  Journal of leukocyte biology 20110401

• An eight-week trial investigating the efficacy and tolerability of atorvastatin for children and adolescents with heterozygous familial hypercholesterolemia.

  Pediatric cardiology 20110401

• Chinese red yeast rice inhibition of prostate tumor growth in SCID mice.

  Cancer prevention research (Philadelphia, Pa.) 20110401

• Arecoline stimulated Cyr61 production in human gingival epithelial cells: inhibition by lovastatin.

  Oral oncology 20110401

• Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells.

  Investigative ophthalmology & visual science 20110325

• Demographic determinants of response to statin medications.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110315

• Aspergillus as a multi-purpose cell factory: current status and perspectives.

  Biotechnology letters 20110301

• Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110301

• Structure elucidation and complete NMR spectral assignment of an unusual aromatic monacolin analog from Monascus purpureus-fermented rice.

  Magnetic resonance in chemistry : MRC 20110301

• Azathioprine-induced fever in sarcoidosis.

  The Annals of pharmacotherapy 20110301

• Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy.

  Iranian journal of kidney diseases 20110301

• Survival rates of early-stage HCV-related liver cirrhosis patients without hepatocellular carcinoma are decreased by alcohol.

  Journal of clinical biochemistry and nutrition 20110301

• Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis.

  PLoS biology 20110301

• Depressogenic effects of medications: a review.

  Dialogues in clinical neuroscience 20110301

• Thrombotic Thrombocytopenic Purpura associated with Clopidogrel: a case report and review of the literature.

  Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110301

• C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20,536 patients in the Heart Protection Study.

  Lancet (London, England) 20110205

• Promotion of Monacolin K production by Agrobacterium tumefaciens-mediated transformation in Monascus albidus 9901.

  Current microbiology 20110201

• Lovastatin enhances paraoxonase enzyme activity and quells low-density lipoprotein susceptibility to oxidation in type 2 diabetic nephropathy.

  Clinical biochemistry 20110201

• Statin therapy in metabolic syndrome and hypertension post-JUPITER: what is the value of CRP?

  Current atherosclerosis reports 20110201

• Suppression of statin effectiveness by copper and zinc in yeast and human cells.

  Molecular bioSystems 20110201

• What combination therapy with a statin, if any, would you recommend?

  Current atherosclerosis reports 20110201

• OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling.

  Atherosclerosis 20110201

• Orthopaedic aspects of neurofibromatosis: update.

  Current opinion in pediatrics 20110201

• Novel extended-release formulation of lovastatin by one-step melt granulation: in vitro and in vivo evaluation.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110201

• Approach to dyslipidemia, lipodystrophy, and cardiovascular risk in patients with HIV infection.

  Current atherosclerosis reports 20110201

• Influence of one-year treatment with lovastatin on myocardial remodeling and ischemia in patients with coronary artery disease.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110201

• In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110201

• May lovastatin target both autism and epilepsy? A novel hypothesized treatment.

  Epilepsy & behavior : E&B 20110201

• Progression of carotid artery intima-media thickness during 12 years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study.

  Diabetes 20110201

• Is red yeast rice safe and effective for lowering serum cholesterol?

  Journal of the American Dietetic Association 20110201

• Lovastatin changes activities of lactate dehydrogenase A and B genes in rat myocardial cells.

  Chinese medical journal 20110201

• Production of lovastatin by wild strains of Aspergillus terreus.

  Natural product communications 20110201

• Letter: a retrospective study on the efficacy of a ten-milligram dosage of atorvastatin for treatment of hypercholesterolemia in type 2 diabetes mellitus patients (korean diabetes j 2010;34:359-67).

  Diabetes & metabolism journal 20110201

• [Retention behavior of statins in microemulsion liquid chromatography].

  Se pu = Chinese journal of chromatography 20110201

• Rosuvastatin reduces nonalcoholic fatty liver disease in patients with chronic hepatitis C treated with α-interferon and ribavirin: Rosuvastatin reduces NAFLD in HCV patients.

  Hepatitis monthly 20110201

• FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.

  Biochemistry 20110118

• Development of biodegradable porous starch foam for improving oral delivery of poorly water soluble drugs.

  International journal of pharmaceutics 20110117

• Lovastatin biosynthesis by Aspergillus terreus with the simultaneous use of lactose and glycerol in a discontinuous fed-batch culture.

  Journal of biotechnology 20110110

• Construction of a novel expression vector in Pseudonocardia autotrophica and its application to efficient biotransformation of compactin to pravastatin, a specific HMG-CoA reductase inhibitor.

  Biochemical and biophysical research communications 20110107

• Medical therapy for advanced pancreatic cancer: work in progress.

  JOP : Journal of the pancreas 20110105

• Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Statins: 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors demonstrate anti-atherosclerotic character due to their antioxidant capacity.

  Applied biochemistry and biotechnology 20110101

• Effects of bile salts on the lovastatin pharmacokinetics following oral administration to rats.

  Drug delivery 20110101

• Proteomics of industrial fungi: trends and insights for biotechnology.

  Applied microbiology and biotechnology 20110101

• Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants.

  Drug metabolism and disposition: the biological fate of chemicals 20110101

• Use of ultra high performance liquid chromatography-tandem mass spectrometry to demonstrate decreased serum statin levels after extracorporeal LDL-cholesterol elimination.

  Journal of biomedicine & biotechnology 20110101

• Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes.

  Endocrinology 20110101

• Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus.

  Epilepsy & behavior : E&B 20110101

• Statins have an early antiplatelet effect in patients with acute myocardial infarction.

  Platelets 20110101

• Effect of hydroxymethylglutaryl-CoA reductase inhibitors on low-density lipoprotein cholesterol, interleukin-6, and high-sensitivity C-reactive protein in end-stage renal disease.

  Iranian journal of kidney diseases 20110101

• Effects of lovastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats: possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by lovastatin.

  The Journal of pharmacy and pharmacology 20110101

• Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata.

  Genes to cells : devoted to molecular & cellular mechanisms 20110101

• Simvastatin is the statin that most efficiently protects against kainate-induced excitotoxicity and memory impairment.

  Journal of Alzheimer's disease : JAD 20110101

• Polyunsaturated fatty acids reduce fatty acid synthase and hydroxy-methyl-glutaryl CoA-reductase gene expression and promote apoptosis in HepG2 cell line.

  Lipids in health and disease 20110101

• Statins reduce dengue virus production via decreased virion assembly.

  Intervirology 20110101

• Cardiovascular prevention of cognitive decline.

  Cardiology research and practice 20110101

• Restoration of cognitive deficits after statin feeding in TBI.

  Restorative neurology and neuroscience 20110101

• Considering statins for cholesterol-reduction in children if lifestyle and diet changes do not improve their health: a review of the risks and benefits.

  Vascular health and risk management 20110101

• Low density lipoprotein receptor gene Ava II polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations.

  Lipids in health and disease 20110101

• Low level bacterial endotoxin activates two distinct signaling pathways in human peripheral blood mononuclear cells.

  Journal of inflammation (London, England) 20110101

• Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage.

  Malaria journal 20110101

• δ-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens.

  Lipids in health and disease 20110101

• Effect of atorvastatin and clopidogrel co-administration after coronary stenting in korean patients with stable angina.

  Korean circulation journal 20110101

• Topical preparations for pain relief: efficacy and patient adherence.

  Journal of pain research 20110101

• Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol.

  PloS one 20110101

• The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals.

  PloS one 20110101

• Synchronous high-performance liquid chromatography with a photodiode array detector and mass spectrometry for the determination of citrinin, monascin, ankaflavin, and the lactone and acid forms of monacolin K in red mold rice.

  Journal of AOAC International 20110101

• Lipoprotein(a) Is the Best Single Marker in Assessing Unstable Angina Pectoris.

  Cardiology research and practice 20110101

• Sex differences in drug disposition.

  Journal of biomedicine & biotechnology 20110101

• Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein.

  PloS one 20110101

• Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy.

  Lipids in health and disease 20110101

• Statins: cardiovascular risk reduction in percutaneous coronary intervention-basic and clinical evidence of hyperacute use of statins.

  International journal of hypertension 20110101

• Structure modeling and inhibitor prediction ofNADP oxidoreductase enzyme from Methanobrevibacter smithii.

  Bioinformation 20110101

• Ticagrelor: the evidence for its clinical potential as an oral antiplatelet treatment for the reduction of major adverse cardiac events in patients with acute coronary syndromes.

  Core evidence 20110101

• Clinical utility of rosuvastatin and other statins for cardiovascular risk reduction among the elderly.

  Clinical interventions in aging 20110101

• Elevated expression of CDK4 in lung cancer.

  Journal of translational medicine 20110101

• NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells.

  PloS one 20110101

• Hypolipidemic potential of ethanolic extract of Verbesina encelioides Benth. roots.

  Acta poloniae pharmaceutica 20110101

• Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries.

  Lipids in health and disease 20110101

• Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males.

  PloS one 20110101

• Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes.

  International journal of Alzheimer's disease 20110101

• Pleiotropic effects of the HMG-CoA reductase inhibitors.

  International journal of general medicine 20110101

• Clinical use and effectiveness of lipid lowering therapies in diabetes mellitus--an observational study from the Swedish National Diabetes Register.

  PloS one 20110101

• Genes associated with prognosis after surgery for malignant pleural mesothelioma promote tumor cell survival in vitro.

  BMC cancer 20110101

• Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism.

  PloS one 20110101

• Long-term use of fenofibrate is associated with increased prevalence of gallstone disease among patients undergoing maintenance hemodialysis.

  Renal failure 20110101

• 'Humanized' stem cell culture techniques: the animal serum controversy.

  Stem cells international 20110101

• Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.

  Clinical & developmental immunology 20110101

• Lipid lowering by hydroalcoholic extracts of Amaranthus caudatus L. induces regression of rabbits atherosclerotic lesions.

  Lipids in health and disease 20110101

• Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.

  PloS one 20110101

• Exploring dietitians' salient beliefs about shared decision-making behaviors.

  Implementation science : IS 20110101

• Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.

  Journal of biomedicine & biotechnology 20110101

• Manipulation of pH shift to enhance the growth and antibiotic activity of Xenorhabdus nematophila.

  Journal of biomedicine & biotechnology 20110101

• Clinical characteristics and evaluation of LDL-cholesterol treatment of the Spanish Familial Hypercholesterolemia Longitudinal Cohort Study (SAFEHEART).

  Lipids in health and disease 20110101

• Aliskiren: An orally active renin inhibitor.

  Journal of pharmacy & bioallied sciences 20110101

• Tolvaptan, hyponatremia, and heart failure.

  International journal of nephrology and renovascular disease 20110101

• The role of fatty aldehyde dehydrogenase in epidermal structure and function.

  Dermato-endocrinology 20110101

• Pathogenesis of the cutaneous phenotype in inherited disorders of cholesterol metabolism: Therapeutic implications for topical treatment of these disorders.

  Dermato-endocrinology 20110101

• The RNA editing pattern of cox2 mRNA is affected by point mutations in plant mitochondria.

  PloS one 20110101

• Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease.

  PloS one 20110101

• Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.

  Pharmacology 20110101

• A comparative study of the pharmacokinetics of traditional and automated dosing/blood sampling systems using gabapentin.

  Indian journal of pharmacology 20110101

• Association of statin therapy with blood pressure control in hypertensive hypercholesterolemic outpatients in clinical practice.

  Journal of cardiovascular disease research 20110101

• Generation of polyclonal antibody with high avidity to rosuvastatin and its use in development of highly sensitive ELISA for determination of rosuvastatin in plasma.

  Chemistry Central journal 20110101

• Synchronization of HeLa cells.

  Methods in molecular biology (Clifton, N.J.) 20110101

• Sensitivity to lovastatin of Saccharomyces cerevisiae strains deleted for pleiotropic drug resistance (PDR) genes.

  Journal of molecular microbiology and biotechnology 20110101

• Stem cells for cardiac repair: status, mechanisms, and new strategies.

  Stem cells international 20110101

• Treating statin-intolerant patients.

  Diabetes, metabolic syndrome and obesity : targets and therapy 20110101

• Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: a cohort study.

  BMC cardiovascular disorders 20110101

• Antiatherogenic Potential of Nigella sativa Seeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• The roles of buyang huanwu decoction in anti-inflammation, antioxidation and regulation of lipid metabolism in rats with myocardial ischemia.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Depression in vascular pathologies: the neurologist's point of view.

  Vascular health and risk management 20110101

• Morphology engineering--osmolality and its effect on Aspergillus niger morphology and productivity.

  Microbial cell factories 20110101

• Deciphering the Actions of Antiparkinsonian and Antipsychotic Drugs on cAMP/DARPP-32 Signaling.

  Frontiers in neuroanatomy 20110101

• Clopidogrel effectively suppresses endothelial microparticle generation induced by indoxyl sulfate via inhibition of the p38 mitogen-activated protein kinase pathway.

  Blood purification 20110101

• Carotid plaque regression following 6-month statin therapy assessed by 3T cardiovascular magnetic resonance: comparison with ultrasound intima media thickness.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20110101

• Ligation of macrophage Fcγ receptors recapitulates the gene expression pattern of vulnerable human carotid plaques.

  PloS one 20110101

• Assessment of cholesterol homeostasis in astrocytes and neurons.

  Methods in molecular biology (Clifton, N.J.) 20110101

• Lysophosphatidic acid and lovastatin might protect kidney in renal I/R injury by downregulating MCP-1 in rat.

  Renal failure 20110101

• Trypanosoma cruzi epimastigotes are able to store and mobilize high amounts of cholesterol in reservosome lipid inclusions.

  PloS one 20110101

• Simultaneous enrichment of deglycosylated ginsenosides and monacolin K in red ginseng by fermentation with Monascus pilosus.

  Bioscience, biotechnology, and biochemistry 20110101

• Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells.

  Journal of biomedical science 20110101

• Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis.

  PloS one 20110101

• Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma.

  Journal of experimental & clinical cancer research : CR 20110101

• Tacrolimus and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: An interaction study in CYP3A5 non-expressors, renal transplant recipients.

  Indian journal of pharmacology 20110101

• Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis.

  Frontiers in pharmacology 20110101

• Response by sex to statin plus ezetimibe or statin monotherapy: a pooled analysis of 22,231 hyperlipidemic patients.

  Lipids in health and disease 20110101

• Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.

  Respiratory research 20110101

• Branch retinal vein occlusion associated with quetiapine fumarate.

  BMC ophthalmology 20110101

• Treatment of allergic asthma: modulation of Th2 cells and their responses.

  Respiratory research 20110101

• Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid--a case report.

  Lipids in health and disease 20110101

• Striatal Signaling in L-DOPA-Induced Dyskinesia: Common Mechanisms with Drug Abuse and Long Term Memory Involving D1 Dopamine Receptor Stimulation.

  Frontiers in neuroanatomy 20110101

• Stepwise approach to myopathy in systemic disease.

  Frontiers in neurology 20110101

• Synthesis, characterization and quantification of simvastatin metabolites and impurities.

  Scientia pharmaceutica 20110101

• Three new compounds from Aspergillus terreus PT06-2 grown in a high salt medium.

  Marine drugs 20110101

• Emerging therapies for severe asthma.

  BMC medicine 20110101

• Formulation and evaluation of solid lipid nanoparticles of ramipril.

  Journal of young pharmacists : JYP 20110101

• Remembering what's new in Alzheimer's management.

  Journal of pharmacology & pharmacotherapeutics 20110101

• High Sensitivity C - Reactive Protein is Associated with Diastolic Dysfunction in Young African Americans without Clinically Evident Cardiac Disease.

  The open cardiovascular medicine journal 20110101

• Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: a cohort study.

  BMC nephrology 20110101

• The hedgehog receptor patched is involved in cholesterol transport.

  PloS one 20110101

• Neuronal (bi)polarity as a self-organized process enhanced by growing membrane.

  PloS one 20110101

• Exposure to statins and risk of common cancers: a series of nested case-control studies.

  BMC cancer 20110101

• Administration of simvastatin after kainic acid-induced status epilepticus restrains chronic temporal lobe epilepsy.

  PloS one 20110101

• Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A₂ (Lp-PLA₂): a review.

  Lipids in health and disease 20110101

• Pulsed electromagnetic fields stimulation prevents steroid-induced osteonecrosis in rats.

  BMC musculoskeletal disorders 20110101

• A retrospective cohort study of the potency of lipid-lowering therapy and race-gender differences in LDL cholesterol control.

  BMC cardiovascular disorders 20110101

• Formulation and characterization of lipid-based drug delivery system of raloxifene-microemulsion and self-microemulsifying drug delivery system.

  Journal of pharmacy & bioallied sciences 20110101

• The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells.

  PloS one 20110101

• Intraperitoneal oxygen/ozone treatment decreases the formation of experimental postsurgical peritoneal adhesions and the levels/activity of the local ubiquitin-proteasome system.

  Mediators of inflammation 20110101

• The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1.

  PloS one 20110101

• Topical treatment of CHILD nevus and Sjögren-Larsson Syndrome with combined lovastatin and cholesterol.

  European journal of dermatology : EJD 20110101

• Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein.

  PloS one 20110101

• Effectiveness of Ezetimibe in Reducing the Estimated Risk for Fatal Cardiovascular Events in Hypercholesterolaemic Patients with Inadequate Lipid Control While on Statin Monotherapy as Measured by the SCORE Model.

  Advances in preventive medicine 20110101

• Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells.

  Respiratory research 20110101

• Challenges associated with tyrosine kinase inhibitor therapy for metastatic thyroid cancer.

  Journal of thyroid research 20110101

• Changes in cholesterol homeostasis modify the response of F1B hamsters to dietary very long chain n-3 and n-6 polyunsaturated fatty acids.

  Lipids in health and disease 20110101

• L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission.

  Frontiers in behavioral neuroscience 20110101

• Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors.

  PloS one 20110101

• Optimal production and biochemical properties of a lipase from Candida albicans.

  International journal of molecular sciences 20110101

• Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity.

  PloS one 20110101

• Predicting in vivo anti-hepatofibrotic drug efficacy based on in vitro high-content analysis.

  PloS one 20110101

• Apolipoprotein E mRNA expression in mononuclear cells from normolipidemic and hypercholesterolemic individuals treated with atorvastatin.

  Lipids in health and disease 20110101

• Diffuse Idiopathic Skeletal Hyperostosis (DISH)-A Rare Etiology of Dysphagia.

  Clinical medicine insights. Arthritis and musculoskeletal disorders 20110101

• Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parameters.

  Clinical Medicine Insights. Cardiology 20110101

• Use of antimony in the treatment of leishmaniasis: current status and future directions.

  Molecular biology international 20110101

• Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.

  PloS one 20110101

• Adaptation to statins restricts human tumour growth in Nude mice.

  BMC cancer 20110101

• Regulation of neutrophil survival/apoptosis by Mcl-1.

  TheScientificWorldJournal 20110101

• Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-β1-induced expression of α-smooth muscle actin in human fetal lung fibroblasts.

  The Journal of toxicological sciences 20110101

• Ras-ERK Signaling in Behavior: Old Questions and New Perspectives.

  Frontiers in behavioral neuroscience 20110101

• P(5A)-type ATPase Cta4p is essential for Ca2+ transport in the endoplasmic reticulum of Schizosaccharomyces pombe.

  PloS one 20110101

• Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.

  Sarcoma 20110101

• Structural basis and kinetics of force-induced conformational changes of an αA domain-containing integrin.

  PloS one 20110101

• Interkingdom gene transfer of a hybrid NPS/PKS from bacteria to filamentous Ascomycota.

  PloS one 20110101

• Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cells.

  BMC neuroscience 20110101

• Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages.

  PloS one 20110101

• Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake.

  International journal of nanomedicine 20110101

• Medical angioplasty - hope and expectations: an optimistic overview.

  Journal of family & community medicine 20110101

• Assessment of monacolin in the fermented products using Monascus purpureus FTC5391.

  Journal of biomedicine & biotechnology 20110101

• Peroxisome Proliferator-Activated Receptor-α Activation Decreases Mean Arterial Pressure, Plasma Interleukin-6, and COX-2 While Increasing Renal CYP4A Expression in an Acute Model of DOCA-Salt Hypertension.

  PPAR research 20110101

• Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers.

  ISRN dentistry 20110101

• Statin-associated muscular and renal adverse events: data mining of the public version of the FDA adverse event reporting system.

  PloS one 20110101

• Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites.

  PloS one 20110101

• Preparation and characterization of pioglitazone cyclodextrin inclusion complexes.

  Journal of young pharmacists : JYP 20110101

• Critical appraisal of ticagrelor in the management of acute coronary syndrome.

  Therapeutics and clinical risk management 20110101

• Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole.

  Clinical pharmacology : advances and applications 20110101

• Mthfs is an Essential Gene in Mice and a Component of the Purinosome.

  Frontiers in genetics 20110101

• Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.

  Scientific reports 20110101

• Formulation and evaluation of controlled-release tablet of zolpidem tartrate by melt granulation technique.

  ISRN pharmaceutics 20110101

• No consensus on definition criteria for stroke registry common data elements.

  Cerebrovascular diseases extra 20110101

• Statin Hepatotoxicity: Is it a Real Concern?

  Heart views : the official journal of the Gulf Heart Association 20110101

• Statins: past and present.

  Heart views : the official journal of the Gulf Heart Association 20110101

• Improved bioavailability through floating microspheres of lovastatin.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

• Renoprotective effects of combining ACE inhibitors and statins in experimental diabetic rats.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

• Approach to lipid screening as a risk marker for cardiovascular disease in pediatric patients with diabetes.

  Frontiers in endocrinology 20110101

• Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter.

  Chemistry & biology 20101222

• Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents.

  International journal of cancer 20101215

• Membrane raft association of the Vpu protein of human immunodeficiency virus type 1 correlates with enhanced virus release.

  Virology 20101205

• Effects of Satureja khuzestanica on Serum Glucose, Lipids and Markers of Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Double-Blind Randomized Controlled Trial.

  Evidence-based complementary and alternative medicine : eCAM 20101201

• Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations.

  Investigational new drugs 20101201

• Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.

  Annals of the rheumatic diseases 20101201

• Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP.

  Molecular and cellular biochemistry 20101201

• In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Detailed molecular fingerprinting of four new anaplastic thyroid carcinoma cell lines and their use for verification of RhoB as a molecular therapeutic target.

  The Journal of clinical endocrinology and metabolism 20101201

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Engineered polyketide biosynthesis and biocatalysis in Escherichia coli.

  Applied microbiology and biotechnology 20101201

• IL-2 costimulation enables statin-mediated activation of human NK cells, preferentially through a mechanism involving CD56+ dendritic cells.

  Cancer research 20101201

• Natural variation in Arabidopsis leads to the identification of REME1, a pentatricopeptide repeat-DYW protein controlling the editing of mitochondrial transcripts.

  Plant physiology 20101201

• Experimental analysis and modelling of in vitro HUVECs proliferation in the presence of various types of drugs.

  Cell proliferation 20101201

• Response surface methodology for lovastatin production by Aspergillus terreus GD13 strain.

  Acta microbiologica et immunologica Hungarica 20101201

• d-δ-Tocotrienol-mediated cell cycle arrest and apoptosis in human melanoma cells.

  Anticancer research 20101201

• Human hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity.

  Indian journal of biochemistry & biophysics 20101201

• Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin.

  Cancer letters 20101128

• Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.

  The Journal of biological chemistry 20101126

• Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives.

  Bioorganic & medicinal chemistry letters 20101115

• Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.

  Lancet (London, England) 20101113

• Potent anti-ischaemic effects of statins in chronic stable angina: incremental benefit beyond lipid lowering?

  European heart journal 20101101

• Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells.

  Annals of hematology 20101101

• Prevalence and overlap of different lipid abnormalities in statin-treated patients at high cardiovascular risk in clinical practice in Germany.

  Clinical research in cardiology : official journal of the German Cardiac Society 20101101

• Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.

  Glia 20101101

• Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum.

  Biotechnology letters 20101101

• Lovastatin raises serum osteoprotegerin level in people with type 2 diabetic nephropathy.

  Clinical biochemistry 20101101

• Effect of fluvastatin, lovastatin, nifedipine and verapamil on the systemic exposure of nateglinide in rabbits.

  Biopharmaceutics & drug disposition 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• The requirement of p53 for maintaining chromosomal stability during tetraploidization.

  Oncotarget 20101101

• Marked variability of monacolin levels in commercial red yeast rice products: buyer beware!

  Archives of internal medicine 20101025

• Synthesis and biological evaluation of a series of aromatic bisphosphonates.

  Bioorganic & medicinal chemistry 20101015

• Accelerated solvent extraction of monacolin K from red yeast rice and purification by high-speed counter-current chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015

• Impact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster.

  Metabolism: clinical and experimental 20101001

• Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells.

  Endocrinology 20101001

• Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency.

  Journal of inherited metabolic disease 20101001

• Effects of lovastatin on the pharmacokinetics of nicardipine in rats.

  Biopharmaceutics & drug disposition 20101001

• High Lipoprotein(a) Levels are Associated With Long-Term Adverse Outcomes in Acute Myocardial Infarction Patients in High Killip Classes.

  Korean circulation journal 20101001

• Are we getting to lipid targets in real life?

  Archives of medical science : AMS 20101001

• Discovering drug-drug interactions: a text-mining and reasoning approach based on properties of drug metabolism.

  Bioinformatics (Oxford, England) 20100915

• Simvastatin-dependent up-regulation of heme oxygenase-1 via mRNA stabilization in human endothelial cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100911

• Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner.

  Neurobiology of aging 20100901

• Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats.

  Evidence-based complementary and alternative medicine : eCAM 20100901

• Do statins beneficially or adversely affect glucose homeostasis?

  Current vascular pharmacology 20100901

• Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20100901

• Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures.

  Applied microbiology and biotechnology 20100901

• Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes.

  Biopolymers 20100901

• Cholesterol depletion affects infectivity and stability of pseudorabies virus.

  Virus research 20100901

• Lovastatin inhibits gap junctional communication in cultured aortic smooth muscle cells.

  Journal of cardiovascular pharmacology and therapeutics 20100901

• Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer.

  European urology 20100901

• Gluconic acid production by Aspergillus terreus.

  Letters in applied microbiology 20100901

• Effectiveness, safety and cost of drug substitution in hypertension.

  British journal of clinical pharmacology 20100901

• Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases.

  Expert reviews in molecular medicine 20100901

• Conversion investigation for lovastatin and its derivatives by HPLC.

  Journal of chromatographic science 20100901

• Persistence with statins and onset of rheumatoid arthritis: a population-based cohort study.

  PLoS medicine 20100901

• Ultrasound diagnosis of bilateral quadriceps tendon rupture after statin use.

  The western journal of emergency medicine 20100901

• Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins.

  Oncogene 20100819

• [Effects of clinically effective dose of lovastatin on prostate cancer PC3 cells].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20100818

• Lipid raft modulation inhibits NSCLC cell migration through delocalization of the focal adhesion complex.

  Lung cancer (Amsterdam, Netherlands) 20100801

• Ichthyosis in Sjögren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion.

  Archives of dermatological research 20100801

• Inhibitory effects of norcantharidin against human lung cancer cell growth and migration.

  Cytotechnology 20100801

• Scavenger receptor-B1 and luteal function in mice.

  Journal of lipid research 20100801

• Colorimetric determination of simvastatin and lovastatin in pure form and in pharmaceutical formulations.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100801

• Unexpected common mechanistic pathways for embryotoxicity of warfarin and lovastatin.

  Reproductive toxicology (Elmsford, N.Y.) 20100801

• Immunomodulatory effects of IFN-beta and lovastatin on immunophenotype of monocyte-derived dendritic cells in multiple sclerosis.

  Archivum immunologiae et therapiae experimentalis 20100801

• Effects of fungal statins on high-glucose-induced mouse mesangial cell hypocontractility may involve filamentous actin, t-complex polypeptide 1 subunit beta, and glucose regulated protein 78.

  Translational research : the journal of laboratory and clinical medicine 20100801

• Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells.

  Anti-cancer drugs 20100801

• Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx.

  British journal of pharmacology 20100801

• Lipid rafts are essential for peroxisome biogenesis in HepG2 cells.

  Hepatology (Baltimore, Md.) 20100801

• [Effect of lovastatin and rosiglitazone on cholesterol reverse transportation in foam cell].

  Zhonghua nei ke za zhi 20100801

• The role of soy in vegetarian diets.

  Nutrients 20100801

• Chronic cholesterol depletion using statin impairs the function and dynamics of human serotonin(1A) receptors.

  Biochemistry 20100706

• Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100701

• A sustained release of lovastatin from biodegradable, elastomeric polyurethane scaffolds for enhanced bone regeneration.

  Tissue engineering. Part A 20100701

• Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.

  Diabetologia 20100701

• Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.

  American journal of physiology. Cell physiology 20100701

• Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03.

  Plant physiology 20100701

• The influence of Sam-Chil-Geun (Panax notoginseng) on the serum lipid levels and inflammations of rats with hyperlipidemia induced by poloxamer-407.

  Yonsei medical journal 20100701

• Current and future pharmacological treatment strategies in X-linked adrenoleukodystrophy.

  Brain pathology (Zurich, Switzerland) 20100701

• Red yeast rice stimulates osteoblast proliferation and increases alkaline phosphatase activity in MC3T3-E1 cells.

  Nutrition research (New York, N.Y.) 20100701

• Influence of drug treatment on glucocorticoid receptor levels in patients with coronary heart disease.

  Chinese medical journal 20100701

• A novel statin-mediated 'prenylation block-and-release' assay provides insight into the membrane targeting mechanisms of small GTPases.

  Biochemical and biophysical research communications 20100618

• Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani.

  Chembiochem : a European journal of chemical biology 20100614

• Effect of niacin ER/lovastatin on claudication symptoms in patients with peripheral artery disease.

  Vascular medicine (London, England) 20100601

• Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4.

  Diabetes 20100601

• Effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits.

  International journal of experimental pathology 20100601

• Severe hypocholesterolaemia is often neglected in haematological malignancies.

  European journal of cancer (Oxford, England : 1990) 20100601

• Statin-associated muscle-related adverse effects: a case series of 354 patients.

  Pharmacotherapy 20100601

• Lovastatin interacts with natural products to influence cultured hepatocarcinoma cell (hep-g2) growth.

  Journal of the American College of Nutrition 20100601

• The role of functional foods, nutraceuticals, and food supplements in intestinal health.

  Nutrients 20100601

• Colloid formation by drugs in simulated intestinal fluid.

  Journal of medicinal chemistry 20100527

• Lovastatin improves neurological outcome after nucleus basalis magnocellularis lesion in rats.

  Neuroscience 20100519

• A historical perspective on the discovery of statins.

  Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100511

• Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase.

  Journal of cellular and molecular medicine 20100501

• Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism.

  Journal of lipid research 20100501

• Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4.

  Mucosal immunology 20100501

• Relationships between metabolic syndrome and other baseline factors and the efficacy of ezetimibe/simvastatin and atorvastatin in patients with type 2 diabetes and hypercholesterolemia.

  Diabetes care 20100501

• Unraveling polyketide synthesis in members of the genus Aspergillus.

  Applied microbiology and biotechnology 20100501

• Soluble epoxide hydrolase in atherosclerosis.

  Current atherosclerosis reports 20100501

• HMG-CoA reductase inhibitor lovastatin causes reversible cytoskeleton perturbation by RhoA signalling suppression in peritoneal cell line Met5A.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20100501

• [Mevastatin inhibits the differentiation of thyroid-associated ophthalmopathy derived orbital preadipocytes].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20100501

• Lipid metabolism and HCV infection.

  Viruses 20100501

• Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry.

  Chembiochem : a European journal of chemical biology 20100412

• Modulation of human T cells signaling transduction by lovastatin.

  International journal of cardiology 20100401

• Enhancement of lovastatin production by supplementing polyketide antibiotics to the submerged culture of Aspergillus terreus.

  Applied biochemistry and biotechnology 20100401

• Hormone and pharmaceutical regulation of ASP production in 3T3-L1 adipocytes.

  Journal of cellular biochemistry 20100401

• Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.

  Diabetes 20100401

• A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells.

  The Journal of pharmacology and experimental therapeutics 20100401

• Effects of mevastatin on grafted bone in MRL/MpJ mice.

  Connective tissue research 20100401

• Radioprotectors and mitigators of radiation-induced normal tissue injury.

  The oncologist 20100401

• PLoS Computational Biology conference postcards from PSB 2010.

  PLoS computational biology 20100401

• A systematic review and meta-analysis on the therapeutic equivalence of statins.

  Journal of clinical pharmacy and therapeutics 20100401

• Effects of grape pomace on the antioxidant defense system in diet-induced hypercholesterolemic rabbits.

  Nutrition research and practice 20100401

• Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation.

  Anticancer research 20100401

• Ochratoxin a: general overview and actual molecular status.

  Toxins 20100401

• Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects: role of P-glycoprotein inhibition by lovastatin.

  European journal of clinical pharmacology 20100301

• Expression, localization, and pharmacological role of Kv7 potassium channels in skeletal muscle proliferation, differentiation, and survival after myotoxic insults.

  The Journal of pharmacology and experimental therapeutics 20100301

• BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1.

  Arteriosclerosis, thrombosis, and vascular biology 20100301

• Effect of statins on the viability of macrophages and smooth muscle cells.

  Journal of cardiovascular pharmacology 20100301

• Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100301

• Drug interactions with HMG-CoA reductase inhibitors (statins): the importance of CYP enzymes, transporters and pharmacogenetics.

  Current opinion in investigational drugs (London, England : 2000) 20100301

• Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome.

  Current atherosclerosis reports 20100301

• [Establishment of a model for evaluating hypolipidemic effect in HepG2 cells].

  Wei sheng yan jiu = Journal of hygiene research 20100301

• Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-regulators: synthesis, structure-activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized rats.

  Journal of medicinal chemistry 20100225

• Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer's risk factors and amyloid beta expression in hyperlipidemic Abeta40-infused rats.

  Journal of agricultural and food chemistry 20100224

• Cholesterol reduction impairs exocytosis of synaptic vesicles.

  Journal of cell science 20100215

• Improvement of trochanteric bone quality in an osteoporosis model after short-term treatment with parathyroid hormone: a new mechanical test for trochanteric region of rat femur.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100201

• Statins potentiate cytostatic/cytotoxic activity of sorafenib but not sunitinib against tumor cell lines in vitro.

  Cancer letters 20100201

• The isoprenoid pathway and transcriptional response to its inhibitors in the yeast Saccharomyces cerevisiae.

  FEMS yeast research 20100201

• In vitro interactions between primycin and different statins in their effects against some clinically important fungi.

  Journal of medical microbiology 20100201

• Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial.

  Diabetes care 20100201

• The PPR protein encoded by the LOVASTATIN INSENSITIVE 1 gene is involved in RNA editing at three sites in mitochondria of Arabidopsis thaliana.

  The Plant journal : for cell and molecular biology 20100201

• The effect of ethanol on oral cocaine pharmacokinetics reveals an unrecognized class of ethanol-mediated drug interactions.

  Drug metabolism and disposition: the biological fate of chemicals 20100201

• Lovastatin-induced cholesterol depletion affects both apical sorting and endocytosis of aquaporin-2 in renal cells.

  American journal of physiology. Renal physiology 20100201

• The mitochondrial PPR protein LOVASTATIN INSENSITIVE 1 plays regulatory roles in cytosolic and plastidial isoprenoid biosynthesis through RNA editing.

  The Plant journal : for cell and molecular biology 20100201

• Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies.

  Experimental neurology 20100201

• Prediction of cardiovascular event risk reduction from lipid changes associated with high potency dyslipidemia therapy.

  Current medical research and opinion 20100201

• Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance.

  Combinatorial chemistry & high throughput screening 20100201

• Measuring hsCRP--an important part of a comprehensive risk profile or a clinically redundant practice?

  PLoS medicine 20100201

• Lovastatin inhibits the thrombin-induced loss of barrier integrity in bovine corneal endothelium.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20100201

• Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level.

  Korean journal of anesthesiology 20100201

• Lovastatin in X-linked adrenoleukodystrophy.

  The New England journal of medicine 20100121

• A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.

  British journal of cancer 20100119

• In vivo evidence of duality effects for lovastatin in a nude mouse cancer model.

  International journal of cancer 20100115

• Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor.

  The Journal of biological chemistry 20100115

• Identification of the mokH gene encoding transcription factor for the upregulation of monacolin K biosynthesis in Monascus pilosus.

  Journal of agricultural and food chemistry 20100113

• Ethanol enhances hepatitis C virus replication through lipid metabolism and elevated NADH/NAD+.

  The Journal of biological chemistry 20100108

• Lovastatin inhibits oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-stimulated interleukin-8 mRNA and protein synthesis in human aortic endothelial cells by depleting stores of geranylgeranyl pyrophosphate.

  Atherosclerosis 20100101

• Development and characterization of a lovastatin-loaded self-microemulsifying drug delivery system.

  Pharmaceutical development and technology 20100101

• Biotechnological production and applications of statins.

  Applied microbiology and biotechnology 20100101

• A role of nitric oxide in neurite outgrowth of neuroblastoma cells triggered by mevastatin or serum reduction.

  Neuroscience letters 20100101

• Drug resistance in visceral leishmaniasis.

  Journal of biomedicine & biotechnology 20100101

• Effect of lovastatin on primary prevention of cardiovascular events in mild CKD and kidney function loss: a post hoc analysis of the Air Force/Texas Coronary Atherosclerosis Prevention Study.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20100101

• Targeting viral infection by microRNA inhibition.

  Genome biology 20100101

• Effects of lovastatin on breast cancer cells: a proteo-metabonomic study.

  Breast cancer research : BCR 20100101

• An alternative treatment of hyperlipidemia with red yeast rice: a case report.

  Journal of medical case reports 20100101

• Evaluation of a pig femoral head osteonecrosis model.

  Journal of orthopaedic surgery and research 20100101

• Current status and future directions in lipid management: emphasizing low-density lipoproteins, high-density lipoproteins, and triglycerides as targets for therapy.

  Vascular health and risk management 20100101

• Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance.

  BMC cancer 20100101

• HMG-CoA reductase inhibitors in kidney transplant recipients receiving tacrolimus: statins not associated with improved patient or graft survival.

  BMC nephrology 20100101

• Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer.

  BMC cancer 20100101

• Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells.

  Pharmacological reports : PR 20100101

• Upregulation of geranylgeranyltransferase I in bronchial smooth muscle of mouse experimental asthma: its inhibition by lovastatin.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20100101

• Simvastatin protects bladder and renal functions following spinal cord injury in rats.

  Journal of inflammation (London, England) 20100101

• Statins and cognitive functioning in the elderly: a population-based study.

  Journal of Alzheimer's disease : JAD 20100101

• Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis.

  Journal of Alzheimer's disease : JAD 20100101

• Metabolic engineering for production of biorenewable fuels and chemicals: contributions of synthetic biology.

  Journal of biomedicine & biotechnology 20100101

• High-content, image-based screening for drug targets in yeast.

  PloS one 20100101

• Critical appraisal of laropiprant and extended-release niacin combination in the management of mixed dyslipidemias and primary hypercholesterolemia.

  Therapeutics and clinical risk management 20100101

• Phenotypic connections in surprising places.

  Genome biology 20100101

• Cardiovascular dementia - a different perspective.

  The open biochemistry journal 20100101

• Major diet-drug interactions affecting the kinetic characteristics and hypolipidaemic properties of statins.

  Nutricion hospitalaria 20100101

• Toxicology and drug delivery by cucurbit[n]uril type molecular containers.

  PloS one 20100101

• Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.

  Arthritis research & therapy 20100101

• A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes.

  Cellular immunology 20100101

• Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database.

  BMJ (Clinical research ed.) 20100101

• Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum.

  Malaria journal 20100101

• Statin treatment and mortality in bacterial infections--a systematic review and meta-analysis.

  PloS one 20100101

• Optimization of the fermentation process of actinomycete strain hhs.015.

  Journal of biomedicine & biotechnology 20100101

• New and extended-action treatments in the management of ADHD: a critical appraisal of lisdexamfetamine in adults and children.

  Neuropsychiatric disease and treatment 20100101

• The risk for significant creatine kinase elevation with statins.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

• Statins in candidemia: clinical outcomes from a matched cohort study.

  BMC infectious diseases 20100101

• Dynamics of lamin-A processing following precursor accumulation.

  PloS one 20100101

• Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication.

  Molecular systems biology 20100101

• Fenofibric acid: a new fibrate approved for use in combination with statin for the treatment of mixed dyslipidemia.

  Vascular health and risk management 20100101

• Lovastatin protects against experimental plague in mice.

  PloS one 20100101

• Paraoxonase: Its antiatherogenic role in chronic renal failure.

  Indian journal of nephrology 20100101

• Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression.

  PloS one 20100101

• Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study.

  Lipids in health and disease 20100101

• Exenatide: a new promising antidiabetic agent.

  Indian journal of pharmaceutical sciences 20100101

• [With red rice against cholesterol?].

  Duodecim; laaketieteellinen aikakauskirja 20100101

• Characterization of the apoptotic response of human leukemia cells to organosulfur compounds.

  BMC cancer 20100101

• Exobiopolymer production of Ophiocordyceps dipterigena BCC 2073: optimization, production in bioreactor and characterization.

  BMC biotechnology 20100101

• Osteogenic activity of locally applied small molecule drugs in a rat femur defect model.

  Journal of biomedicine & biotechnology 20100101

• Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes.

  Lipids in health and disease 20100101

• Differences in efficacy and safety of pharmaceutical treatments between men and women: an umbrella review.

  PloS one 20100101

• Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations.

  Breast cancer research : BCR 20100101

• Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism.

  BMC biochemistry 20100101

• Activating Transcription Factor 3 regulates in part the enhanced tumour cell cytotoxicity of the histone deacetylase inhibitor M344 and cisplatin in combination.

  Cancer cell international 20100101

• Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors.

  PloS one 20100101

• Chicken model of steroid-induced bone marrow adipogenesis using proteome analysis: a preliminary study.

  Proteome science 20100101

• Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway.

  Journal of experimental & clinical cancer research : CR 20100101

• Analysis of a vascular screening program in a rural community.

  Journal of cardiovascular disease research 20100101

• Plant sterols, marine-derived omega-3 fatty acids and other functional ingredients: a new frontier for treating hyperlipidemia.

  Nutrition & metabolism 20100101

• Statins and clinical outcome of acute ischemic stroke: a systematic review.

  International archives of medicine 20100101

• FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors.

  Molecular cancer 20100101

• Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLs.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20100101

• Benefits of statin therapy and compliance in high risk cardiovascular patients.

  Vascular health and risk management 20100101

• The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males.

  Journal of the International Society of Sports Nutrition 20100101

• Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease.

  Molecular neurodegeneration 20100101

• Drug interaction and pharmacist.

  Journal of young pharmacists : JYP 20100101

• A new fluorescence-based method identifies protein phosphatases regulating lipid droplet metabolism.

  PloS one 20100101

• A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.).

  BMC plant biology 20100101

• Niacin or ezetimibe for patients with, or at risk of coronary heart disease.

  Clinical Medicine Insights. Cardiology 20100101

• The cost effectiveness of statin therapies in Spain in 2010, after the introduction of generics and reference prices.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

• Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston].

  BMC molecular biology 20100101

• Clinical evaluation of Dyslipidemia among type II diabetic patients at Public hospital Penang, Malaysia.

  International archives of medicine 20100101

• [Effect of polymorphisms of cytochrome P450 and apolipoprotein E genes on therapeutic efficacy of statins].

  Kardiologiia 20100101

• [Effect of lovastatin on adhesive and aggregation function of platelets in patients with arterial hypertension and dislipidemia].

  Klinicheskaia meditsina 20100101

• Synergic effect of eicosapentaenoic acid and lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells.

  Lipids in health and disease 20100101

• Combination therapy of statin and ezetimibe for the treatment of familial hypercholesterolemia.

  Vascular health and risk management 20100101

• Low high-density lipoprotein cholesterol: current status and future strategies for management.

  Vascular health and risk management 20100101

• Pitavastatin approved for treatment of primary hypercholesterolemia and combined dyslipidemia.

  Vascular health and risk management 20100101

• Use of hamster as a model to study diet-induced atherosclerosis.

  Nutrition & metabolism 20100101

• A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.

  PloS one 20100101

• Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.

  PloS one 20100101

• Simvastatin impairs murine melanoma growth.

  Lipids in health and disease 20100101

• Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.

  Lipids in health and disease 20100101

• Use of the Joint British Society cardiovascular risk calculator before initiating statins for primary prevention in hospital medicine: experience from a large university teaching hospital.

  International journal of general medicine 20100101

• Combination of niacin extended-release and simvastatin results in a less atherogenic lipid profile than atorvastatin monotherapy.

  Vascular health and risk management 20100101

• Optimal management of familial hypercholesterolemia: treatment and management strategies.

  Vascular health and risk management 20100101

• Pilot study: rapidly cycling hypobaric pressure improves pain after 5 days in adiposis dolorosa.

  Journal of pain research 20100101

• Statins STAT for (over)ventilated patients?

  Critical care (London, England) 20100101

• Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective.

  Drug design, development and therapy 20100101

• Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.

  The open cardiovascular medicine journal 20100101

• Role of bone marrow-derived monocytes/macrophages in the repair of mucosal damage caused by irradiation and/or anticancer drugs in colitis model.

  Mediators of inflammation 20100101

• Controversial data on simvastatin in asthma: What about the rat model?

  Journal of asthma and allergy 20100101

• Vitamin B12 Deficiency due to Chlorofluorocarbon: A Case Report.

  Case reports in medicine 20100101

• Pitavastatin: evidence for its place in treatment of hypercholesterolemia.

  Core evidence 20100101

• Lipid Metabolism and Cardiovascular Risk in HIV-1 Infection and HAART: Present and Future Problems.

  Cholesterol 20100101

• Randomized Trial of a Pharmacist-Delivered Intervention for Improving Lipid-Lowering Medication Adherence among Patients with Coronary Heart Disease.

  Cholesterol 20100101

• [Evidence-based grounds of the efficacy of simvastatin (zocor): 15 years later].

  Terapevticheskii arkhiv 20100101

• Rosuvastatin counteracts vessel arterialisation and sinusoid capillarisation, reduces tumour growth, and prolongs survival in murine hepatocellular carcinoma.

  Gastroenterology research and practice 20100101

• Functional toxicogenomics: mechanism-centered toxicology.

  International journal of molecular sciences 20100101

• Safety and efficacy of laropiprant and extended-release niacin combination in the management of mixed dyslipidemias and primary hypercholesterolemia.

  Drug, healthcare and patient safety 20100101

• Screening of nutrient parameters for mevastatin production by Penicillium citrinum MTCC 1256 under submerged fermentation using the Plackett-Burman design.

  Journal of pharmacy & bioallied sciences 20100101

• Traditional used Plants against Cognitive Decline and Alzheimer Disease.

  Frontiers in pharmacology 20100101

• Policies to enhance prescribing efficiency in europe: findings and future implications.

  Frontiers in pharmacology 20100101

• Cytotoxic evaluation of doxorubicin in combination with simvastatin against human cancer cells.

  Research in pharmaceutical sciences 20100101

• Long-term treatment of patients with HIV-1: the role of atazanavir.

  HIV/AIDS (Auckland, N.Z.) 20100101

• Individualized initiation of statin therapy determined by baseline LDL-C: Are you more likely to achieve goal LDL-C?

  Risk management and healthcare policy 20100101

• Comparing the effects of lovastatin and cornus MAS fruit on fibrinogen level in hypercholesterolemic rabbits.

  ARYA atherosclerosis 20100101

• Iatrogenic Femoral Artery Pseudoaneurysm (REVIEW OF TREATMENT OPTIONS).

  ARYA atherosclerosis 20100101

• Pharmacological management of metabolic syndrome and its lipid complications.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101

• Operons.

  Cellular and molecular life sciences : CMLS 20091201

• Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201

• Identification of mokB involved in monacolin K biosynthesis in Monascus pilosus.

  Biotechnology letters 20091201

• The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro.

  Bone 20091201

• HTS and hit finding in academia--from chemical genomics to drug discovery.

  Drug discovery today 20091201

• Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis.

  British journal of pharmacology 20091201

• Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20091201

• Statins: in the beginning.

  The journal of the Royal College of Physicians of Edinburgh 20091201

• Cooperation between a coenzyme A-independent stand-alone initiation module and an iterative type I polyketide synthase during synthesis of mycobacterial phenolic glycolipids.

  Journal of the American Chemical Society 20091125

• Simvastatin as a potential therapeutic for acute respiratory distress syndrome.

  American journal of respiratory and critical care medicine 20091115

• Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism.

  Virology 20091110

• Compactin production studies using Penicillium brevicompactum under solid-state fermentation conditions.

  Applied biochemistry and biotechnology 20091101

• Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus.

  Journal of neuroscience research 20091101

• Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin.

  Experimental cell research 20091101

• Determination of the extent of phosphopantetheinylation of polyketide synthases expressed in Escherichia coli and Saccharomyces cerevisiae.

  Analytical biochemistry 20091101

• LFA-1 antagonists as agents limiting human immunodeficiency virus type 1 infection and transmission and potentiating the effect of the fusion inhibitor T-20.

  Antimicrobial agents and chemotherapy 20091101

• 7-Difluoromethyl-5,4'-dimethoxygenistein, a novel genistein derivative, has therapeutic effects on atherosclerosis in a rabbit model.

  Journal of cardiovascular pharmacology 20091101

• Impact of fixed-dose and multi-pill combination dyslipidemia therapies on medication adherence and the economic burden of sub-optimal adherence.

  Current medical research and opinion 20091101

• Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins.

  International journal of molecular medicine 20091101

• Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention.

  International journal of oncology 20091101

• Quantitative determination of geranyl diphosphate levels in cultured human cells.

  Lipids 20091101

• A hidden Markov model for single particle tracks quantifies dynamic interactions between LFA-1 and the actin cytoskeleton.

  PLoS computational biology 20091101

• Coronary pressure measurement based decision making for percutaneous coronary intervention.

  Current cardiology reviews 20091101

• Complete reconstitution of a highly reducing iterative polyketide synthase.

  Science (New York, N.Y.) 20091023

• Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine.

  The Journal of biological chemistry 20091016

• Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells.

  Biochemical pharmacology 20091015

• Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment.

  Lipids 20091001

• Statin therapy and risk of developing type 2 diabetes: a meta-analysis.

  Diabetes care 20091001

• Effects of lovastatin on the pharmacokinetics of verapamil and its active metabolite, norverapamil in rats: possible role of P-glycoprotein inhibition by lovastatin.

  Archives of pharmacal research 20091001

• Preventing and managing cardiometabolic risk: the logic for intervention.

  International journal of environmental research and public health 20091001

• Hypolipidemic effects of Monascus-fermented soybean extracts in rats fed a high-fat and -cholesterol diet.

  Journal of agricultural and food chemistry 20090923

• The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells.

  Journal of agricultural and food chemistry 20090923

• [18F]fluorodeoxyglucose positron emission tomography for lung antiinflammatory response evaluation.

  American journal of respiratory and critical care medicine 20090915

• Effects of increasing high-density lipoprotein cholesterol and decreasing low-density lipoprotein cholesterol on the incidence of first acute coronary events (from the Air Force/Texas Coronary Atherosclerosis Prevention Study).

  The American journal of cardiology 20090915

• Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090909

• Survivin plays as a resistant factor against tamoxifen-induced apoptosis in human breast cancer cells.

  Breast cancer research and treatment 20090901

• Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090901

• The use of simvastatin in bone regeneration.

  Medicina oral, patologia oral y cirugia bucal 20090901

• Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20090901

• Ultrasound assisted ionic liquid dispersive liquid phase extraction of lovastatin and simvastatin: a new pretreatment procedure.

  Journal of separation science 20090901

• Inhibition of platelet-rich arterial thrombus in vivo: acute antithrombotic effect of intravenous HMG-CoA reductase therapy.

  Arteriosclerosis, thrombosis, and vascular biology 20090901

• Using basic science to design a clinical trial: baseline characteristics of women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS).

  Journal of cardiovascular translational research 20090901

• Molecular mechanisms underlying the cholesterol-lowering effect of Ginkgo biloba extract in hepatocytes: a comparative study with lovastatin.

  Acta pharmacologica Sinica 20090901

• A simple and sensitive HPLC-UV method for quantitation of lovastatin in human plasma: application to a bioequivalence study.

  Biological & pharmaceutical bulletin 20090901

• REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

  PLoS biology 20090901

• Short term treatment with clarithromycin resulting in colchicine-induced rhabdomyolysis.

  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20090901

• Rhabdomyolysis a result of azithromycin and statins: an unrecognized interaction.

  British journal of clinical pharmacology 20090901

• Control of chondrocyte gene expression by actin dynamics: a novel role of cholesterol/Ror-alpha signalling in endochondral bone growth.

  Journal of cellular and molecular medicine 20090901

• Cloning and bioinformatic analysis of lovastatin biosynthesis regulatory gene lovE.

  Chinese medical journal 20090805

• Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepatocellular carcinoma.

  Cancer chemotherapy and pharmacology 20090801

• Red yeast rice fermentation by selected Monascus sp. with deep-red color, lovastatin production but no citrinin, and effect of temperature-shift cultivation on lovastatin production.

  Applied biochemistry and biotechnology 20090801

• Different differentiation of stroma cells from patients with osteonecrosis: a pilot study.

  Clinical orthopaedics and related research 20090801

• 3-hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation.

  Journal of cellular physiology 20090801

• Safety evaluation of Monascus purpureus red mould rice in albino rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801

• Myelin proteomics: molecular anatomy of an insulating sheath.

  Molecular neurobiology 20090801

• Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors.

  Bioorganic & medicinal chemistry letters 20090801

• Synthesis and evaluation of 1-(benzo[b]thiophen-2-yl)ethanone analogues as novel anti-osteoporosis agents acting on BMP-2 promotor.

  Bioorganic & medicinal chemistry letters 20090801

• OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.

  Journal of molecular medicine (Berlin, Germany) 20090801

• Autocrine amplification loop in statin-induced apoptosis of human melanoma cells.

  British journal of pharmacology 20090801

• High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART).

  Cerebrovascular diseases (Basel, Switzerland) 20090801

• High lovastatin production by Aspergillus terreus in solid-state fermentation on polyurethane foam: an artificial inert support.

  Journal of bioscience and bioengineering 20090801

• No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

  British journal of clinical pharmacology 20090801

• A comparison of pectin, polyphenols, and phytosterols, alone or in combination, to lovastatin for reduction of serum lipids in familial hypercholesterolemic swine.

  Journal of medicinal food 20090801

• Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target.

  Life sciences 20090731

• Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR.

  Journal of neuroscience research 20090701

• Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090701

• Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development.

  Hepatology (Baltimore, Md.) 20090701

• Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells.

  British journal of pharmacology 20090701

• Comparison of common carotid artery intima-media thickness between Brazilian Euro-descendants and Afro-descendants with atherosclerosis risk factors.

  Clinics (Sao Paulo, Brazil) 20090701

• Serum levels of lipoprotein(a) and homocysteine in patients on hemodialysis who take hydroxymethylglutaryl-CoA reductase inhibitors, vitamin B6, and folic acid.

  Iranian journal of kidney diseases 20090701

• Effect of precultural and nutritional parameters on compactin production by solid-state fermentation.

  Journal of microbiology and biotechnology 20090701

• [Determination of lovastatin and its active metabolites in human plasma with high performance liquid chromatography-tandem mass spectrometry].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090701

• Effect of folate supplementation on serum homocysteine and plasma total antioxidant capacity in hypercholesterolemic adults under lovastatin treatment: a double-blind randomized controlled clinical trial.

  Archives of medical research 20090701

• Acyltransferase mediated polyketide release from a fungal megasynthase.

  Journal of the American Chemical Society 20090624

• Cholesterol biosynthesis modulation regulates dengue viral replication.

  Virology 20090620

• Systemic administration of HMG-CoA reductase inhibitor protects the blood-retinal barrier and ameliorates retinal inflammation in type 2 diabetes.

  Experimental eye research 20090615

• Elevated creatine phosphokinase levels associated with linezolid therapy.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090615

• Variability in responsiveness to lovastatin of the primitive CD34+ AML subfraction compared to normal CD34+ cells.

  Annals of hematology 20090601

• High-dose lovastatin decreased basal prostacyclin production in cultured endothelial cells.

  Prostaglandins & other lipid mediators 20090601

• Increased RhoA and RhoB protein accumulation in cultured human trabecular meshwork cells by lovastatin.

  Investigative ophthalmology & visual science 20090601

• MlcR, a zinc cluster activator protein, is able to bind to a single (A/T)CGG site of cognate asymmetric motifs in the ML-236B (compactin) biosynthetic gene cluster.

  Molecular genetics and genomics : MGG 20090601

• Improvement of compactin (ML-236B) production by genetic engineering in compactin high-producing Penicillium citrinum.

  Applied microbiology and biotechnology 20090601

• Statin-induced liver injury involves cross-talk between cholesterol and selenoprotein biosynthetic pathways.

  Molecular pharmacology 20090601

• Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1.

  Experimental biology and medicine (Maywood, N.J.) 20090601

• Acute hepatitis caused by a natural lipid-lowering product: when 'alternative' medicine is no 'alternative' at all.

  Journal of hepatology 20090601

• [Effect of intensive treatment with atorvastatin versus standard doses of statins on the risk of stroke. A meta-analysis from five randomized trials including 25,709 patients].

  Revista de neurologia 20090601

• Impact of apolipoprotein A5 variants on statin treatment efficacy.

  Pharmacogenomics 20090601

• Efflux in fungi: la pièce de résistance.

  PLoS pathogens 20090601

• Safety and efficacy of red yeast rice (Monascus purpureus) as an alternative therapy for hyperlipidemia.

  P & T : a peer-reviewed journal for formulary management 20090601

• Screening and selection of lovastatin hyper-producing mutants of Aspergillus terreus using cyclic mutagenesis.

  Acta microbiologica et immunologica Hungarica 20090601

• Adult reversal of cognitive phenotypes in neurodevelopmental disorders.

  Journal of neurodevelopmental disorders 20090601

• Human caspase 7 is positively controlled by SREBP-1 and SREBP-2.

  The Biochemical journal 20090527

• Comparison of UV and charged aerosol detection approach in pharmaceutical analysis of statins.

  Talanta 20090515

• Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line.

  The Biochemical journal 20090513

• How essential is cholesterol?

  The Biochemical journal 20090513

• Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090512

• Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography.

  Journal of biomechanics 20090511

• Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression.

  Cancer chemotherapy and pharmacology 20090501

• Induction of iodide uptake in transformed thyrocytes: a compound screening in cell lines.

  European journal of nuclear medicine and molecular imaging 20090501

• Digoxin and ouabain increase the synthesis of cholesterol in human liver cells.

  Cellular and molecular life sciences : CMLS 20090501

• d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells.

  Pancreas 20090501

• Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras.

  Oncology reports 20090501

• Complete blockage of the mevalonate pathway results in male gametophyte lethality.

  Journal of experimental botany 20090501

• The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae.

  FEMS yeast research 20090501

• Lovastatin restores the function of endothelial progenitor cells damaged by oxLDL.

  Acta pharmacologica Sinica 20090501

• Physiological, morphological and kinetic aspects of lovastatin biosynthesis by Aspergillus terreus.

  Biotechnology journal 20090501

• Managing toxicities and optimal dosing of targeted drugs in advanced kidney cancer.

  Current oncology (Toronto, Ont.) 20090501

• Asymmetric dimethylarginine (ADMA) and endothelial dysfunction: implications for atherogenesis.

  Clinics (Sao Paulo, Brazil) 20090501

• Trypanosoma cruzi: participation of cholesterol and placental alkaline phosphatase in the host cell invasion.

  Experimental parasitology 20090501

• Heart Disease in Patients with HIV/AIDS-An Emerging Clinical Problem.

  Current cardiology reviews 20090501

• The ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions.

  BMB reports 20090430

• Efficient biotransformations using Escherichia coli with tolC acrAB mutations expressing cytochrome P450 genes.

  Bioscience, biotechnology, and biochemistry 20090423

• Statins for the prevention of dementia.

  The Cochrane database of systematic reviews 20090415

• The g.-762T>C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels.

  Journal of human genetics 20090401

• AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease.

  Clinical science (London, England : 1979) 20090401

• A platform to standardize, store, and visualize proteomics experimental data.

  Acta biochimica et biophysica Sinica 20090401

• Towards prediction of metabolic products of polyketide synthases: an in silico analysis.

  PLoS computational biology 20090401

• Modified local straight-line screening to detect synthetic drugs in adulterated herbal medicines.

  Applied spectroscopy 20090401

• C-reactive protein level following treatment and withdrawal of lovastatin in diabetic nephropathy.

  Iranian journal of kidney diseases 20090401

• HIV entry in macrophages is dependent on intact lipid rafts.

  Virology 20090330

• Lovastatin induces the formation of abnormal myelin-like membrane sheets in primary oligodendrocytes.

  Glia 20090301

• Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats.

  Pharmacology, biochemistry, and behavior 20090301

• Effect of Curcuma kwangsiensis polysaccharides on blood lipid profiles and oxidative stress in high-fat rats.

  International journal of biological macromolecules 20090301

• Molecular beacons can assess changes in expression and 3'-polyadenylation of human eNOS mRNA.

  American journal of physiology. Cell physiology 20090301

• Effects of rutin on lipid profile in hypercholesterolaemic rats.

  Basic & clinical pharmacology & toxicology 20090301

• Rhabdomyolysis caused by a potential sitagliptin-lovastatin interaction.

  Pharmacotherapy 20090301

• Cholesterol-dependent anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway.

  PLoS pathogens 20090301

• Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo.

  Journal of cell communication and signaling 20090301

• The carotenogenesis pathway via the isoprenoid-beta-carotene interference approach in a new strain of Dunaliella salina isolated from Baja California Mexico.

  Marine drugs 20090301

• Mevinolin enhances osteogenic genes (ALP, type I collagen and osteocalcin), CD44, CD47 and CD51 expression during osteogenic differentiation.

  Life sciences 20090227

• Oxysterol activation of phosphatidylcholine synthesis involves CTP:phosphocholine cytidylyltransferase alpha translocation to the nuclear envelope.

  The Biochemical journal 20090215

• [Statin therapy and muscle disorders].

  Orvosi hetilap 20090208

• [Comment from the lipidologic viewpoint].

  Praxis 20090204

• Enhancement of drug solubility in supramolecular and colloidal systems.

  Journal of pharmaceutical sciences 20090201

• Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation.

  Osteoarthritis and cartilage 20090201

• Differential influence of different dietary fatty acids on very low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants.

  Metabolism: clinical and experimental 20090201

• Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?

  Metabolism: clinical and experimental 20090201

• Hematologic parameters, atherosclerotic progression, and prognosis in patients with previous coronary artery bypass grafting (from the Post CABG Trial).

  The American journal of cardiology 20090201

• Lack of efficacy of the statins atorvastatin and lovastatin in rodent mammary carcinogenesis.

  Cancer prevention research (Philadelphia, Pa.) 20090201

• Co-medication of statins and CYP3A4 inhibitors before and after introduction of new reimbursement policy.

  British journal of clinical pharmacology 20090201

• The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: an updated meta-analysis.

  Clinical therapeutics 20090201

• [Local straight line screening method for the detection of Chinese proprietary medicines containing undeclared prescription drugs].

  Guang pu xue yu guang pu fen xi = Guang pu 20090201

• The effect of dyslipidemic drugs on mortality: A meta-analysis.

  Indian journal of pharmacology 20090201

• Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis.

  Glia 20090115

• Cloning of the Rhizomucor miehei 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene and its heterologous expression in Mucor circinelloides.

  Antonie van Leeuwenhoek 20090101

• Aspergillus westerdijkiae polyketide synthase gene 'aoks1' is involved in the biosynthesis of ochratoxin A.

  Fungal genetics and biology : FG & B 20090101

• Does nicotinic acid (niacin) lower blood pressure?

  International journal of clinical practice 20090101

• Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.

  Bioorganic & medicinal chemistry 20090101

• Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus.

  BMC chemical biology 20090101

• The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression.

  PloS one 20090101

• Survey of physician knowledge regarding antiretroviral medications in hospitalized HIV-infected patients.

  Journal of the International AIDS Society 20090101

• Neural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression.

  BMC neuroscience 20090101

• Effects of statins on the secretion of human serum albumin in cultured HepG2 cells.

  Journal of biomedical science 20090101

• Campylobacter jejuni induces transcellular translocation of commensal bacteria via lipid rafts.

  Gut pathogens 20090101

• Fungal type I polyketide synthases.

  Methods in enzymology 20090101

• Neuroprotective effects of statins in an in vitro model of Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20090101

• Pretreatment with lovastatin prevents N-methyl-D-aspartate-induced neurodegeneration in the magnocellular nucleus basalis and behavioral dysfunction.

  Journal of Alzheimer's disease : JAD 20090101

• Chapter 2. From microbial products to novel drugs that target a multitude of disease indications.

  Methods in enzymology 20090101

• The influence of lovastatin on thrombomodulin gene expression in vascular endothelial cells--in vitro study.

  Folia histochemica et cytobiologica 20090101

• Ten-Year Survival in 75-Year-Old Men and Women: Predictive Ability of Total Cholesterol, HDL-C, and LDL-C.

  Current gerontology and geriatrics research 20090101

• Role of atazanavir in the treatment of HIV infection.

  Therapeutics and clinical risk management 20090101

• Efficacy and safety of rosuvastatin in the management of dyslipidemia.

  Vascular health and risk management 20090101

• Prevention of atherosclerosis in patients living with HIV.

  Vascular health and risk management 20090101

• Management of complex lipid abnormalities with a fixed dose combination of simvastatin and extended release niacin.

  Vascular health and risk management 20090101

• Dyslipidemia treatment of patients with diabetes mellitus in a US managed care plan: a retrospective database analysis.

  Cardiovascular diabetology 20090101

• Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?

  The open neurology journal 20090101

• Efficacy, effectiveness and real life goal attainment of statins in managing cardiovascular risk.

  Vascular health and risk management 20090101

• Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors.

  Vascular health and risk management 20090101

• Impact of statins and ACE inhibitors on mortality after COPD exacerbations.

  Respiratory research 20090101

• SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis.

  PloS one 20090101

• Lovastatin enhances the genotoxicity of doxorubicin in Chinese hamster V79 cells via noncovalent DNA binding.

  Drug and chemical toxicology 20090101

• The biosynthesis and accumulation of beta-carotene in Dunaliella salina proceed via the glyceraldehyde 3-phosphate/pyruvate pathway.

  Natural product research 20090101

• Statin use and risk of community acquired pneumonia in older people: population based case-control study.

  BMJ (Clinical research ed.) 20090101

• Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial.

  Trials 20090101

• Effect of HMG-CoA reductase inhibitors on activation of human gammadeltaT cells induced by Mycobacterium tuberculosis antigens.

  Immunopharmacology and immunotoxicology 20090101

• Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?

  Neuropsychiatric disease and treatment 20090101

• A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation.

  PloS one 20090101

• The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials.

  BMJ (Clinical research ed.) 20090101

• Leptin stimulated C-reactive protein production by human coronary artery endothelial cells.

  Journal of vascular research 20090101

• Substance P scavenger enhances antioxidant defenses and prevents prothrombotic effects on the rat lung after acute exposure to oil smoke.

  Journal of biomedical science 20090101

• Associations between statins and COPD: a systematic review.

  BMC pulmonary medicine 20090101

• Statin-induced calcification in human mesenchymal stem cells is cell death related.

  Journal of cellular and molecular medicine 20090101

• Regulation of bile acid and cholesterol metabolism by PPARs.

  PPAR research 20090101

• New options in the treatment of lipid disorders in HIV-infected patients.

  The open AIDS journal 20090101

• Characteristics, management and attainment of lipid target levels in diabetic and cardiac patients enrolled in Disease Management Program versus those in routine care: LUTZ registry.

  BMC public health 20090101

• Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

  Interdisciplinary perspectives on infectious diseases 20090101

• Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir.

  Therapeutics and clinical risk management 20090101

• Utilization of genomic signatures to identify phenotype-specific drugs.

  PloS one 20090101

• Myopathy with concurrent tadalafil and simvastatin.

  Case reports in medicine 20090101

• Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study.

  Breast cancer research : BCR 20090101

• Management of avascular necrosis of femoral head at pre-collapse stage.

  Indian journal of orthopaedics 20090101

• Effects of lovastatin and pentoxyphyllin in nonalcoholic steatohepatitis.

  Hepato-gastroenterology 20090101

• Decreased ubiquinone availability and impaired mitochondrial cytochrome oxidase activity associated with statin treatment.

  Toxicology mechanisms and methods 20090101

• Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action.

  Molecular cancer 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• [Statins in practice of the vascular surgeon and cardiologist].

  Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20090101

• Thinking beyond low-density lipoprotein cholesterol: strategies to further reduce cardiovascular risk.

  Vascular health and risk management 20090101

• Apoptosis of lens epithelial cells induced by high concentration of glucose is associated with a decrease in caveolin-1 levels.

  Molecular vision 20090101

• A 60-year-old man with chronic renal failure and a costal mass: a case report and review of the literature.

  Journal of medical case reports 20090101

• Pleiotropic vasoprotective effects of statins: the chicken or the egg?

  Drug design, development and therapy 20090101

• Increased frequency and nocturia in a middle aged male may not always be due to Benign Prostatic Hypertrophy (BPH): a case report.

  Cases journal 20090101

• Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

  Lipids in health and disease 20090101

• Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.

  PloS one 20090101

• Influenza morbidity and mortality in elderly patients receiving statins: a cohort study.

  PloS one 20090101

• Management of dyslipidemia in children.

  Diabetology & metabolic syndrome 20090101

• [Achievement of blood lipid target levels with Ezetimibe/Simvastatin in patients with atherosclerosis and/or diabetes mellitus--an Austrian observational study].

  Wiener medizinische Wochenschrift (1946) 20090101

• Fatal hemopericardial tamponade due to primary pericardial mesothelioma: a case report.

  Diagnostic pathology 20090101

• Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway.

  BMC cancer 20090101

• Model system for the analysis of cell surface expression of human ABCA1.

  BMC cell biology 20090101

• SP-D counteracts GM-CSF-mediated increase of granuloma formation by alveolar macrophages in lysinuric protein intolerance.

  Orphanet journal of rare diseases 20090101

• The JUPITER and AURORA clinical trials for rosuvastatin in special primary prevention populations: perspectives, outcomes, and consequences.

  Vascular health and risk management 20090101

• Dermatomyositis presenting with rhabdomyolysis and acute renal failure; an uncommon manifestation.

  Annals of Indian Academy of Neurology 20090101

• Lipid abnormalities in streptozotocin-diabetes: Amelioration by Morus indica L. cv Suguna leaves.

  International journal of diabetes in developing countries 20090101

• Increased frequency and nocturia in a middle aged male may not always be due to benign prostatic hypertrophy: a case report.

  Cases journal 20090101

• Lovastatin and fluvastatin reduce viremia and the pro-inflammatory cytokines in the patients with chronic hepatitis C.

  Hepato-gastroenterology 20090101

• Acute coronary syndrome in pregnancy.

  Clinical medicine. Cardiology 20090101

• Targeted therapy in the treatment of malignant gliomas.

  OncoTargets and therapy 20090101

• Epidemiologic characteristics and risk factors for renal cell cancer.

  Clinical epidemiology 20090101

• Raising HDL cholesterol in women.

  International journal of women's health 20090101

• Improving glycemic and cholesterol control through an integrated approach incorporating colesevelam - a clinical perspective.

  Diabetes, metabolic syndrome and obesity : targets and therapy 20090101

• Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin.

  Molecular medicine reports 20090101

• Long-term use of rosuvastatin: a critical risk benefit appraisal and comparison with other antihyperlipidemics.

  Drug, healthcare and patient safety 20090101

• Reconstruction of a bacterial isoprenoid biosynthetic pathway in Saccharomyces cerevisiae.

  FEBS letters 20081210

• Berberine decreases PCSK9 expression in HepG2 cells.

  Atherosclerosis 20081201

• Statin cost-effectiveness comparisons using real-world effectiveness data: formulary implications.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20081201

• Lovastatin inhibits adipogenesis and prevents osteonecrosis in steroid-treated rabbits.

  Joint, bone, spine : revue du rhumatisme 20081201

• Actin cytoskeleton remodeling governs aquaporin-4 localization in astrocytes.

  Glia 20081201

• Interaction between statins and clopidogrel: is there anything clinically relevant?

  QJM : monthly journal of the Association of Physicians 20081201

• Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis.

  Experimental neurology 20081201

• Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state.

  Journal of molecular medicine (Berlin, Germany) 20081201

• Comparative evaluation of the hypolipidemic effects of coconut water and lovastatin in rats fed fat-cholesterol enriched diet.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

• Molecular characterization of the Aspergillus fumigatus NCS-1 homologue, NcsA.

  Molecular genetics and genomics : MGG 20081201

• Myotoxicity of lipid-lowering agents in a teenager with MELAS mutation.

  Pediatric neurology 20081201

• Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer.

  Cancer science 20081201

• Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression.

  Journal of medicinal food 20081201

• Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats.

  Archives of pharmacal research 20081201

• Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques.

  AAPS PharmSciTech 20081201

• Bama miniature pigs (Sus scrofa domestica) as a model for drug evaluation for humans: comparison of in vitro metabolism and in vivo pharmacokinetics of lovastatin.

  Comparative medicine 20081201

• Fifth International Workshop on the CCN Family of Genes: Abstracts and Posters October 18-22, 2008.

  Journal of cell communication and signaling 20081201

• Report on the fifth international workshop on the CCN family of genes.

  Journal of cell communication and signaling 20081201

• Tolerability and effects on lipids of ezetimibe coadministered with pravastatin or simvastatin for twelve months: results from two open-label extension studies in hypercholesterolemic patients.

  Clinical therapeutics 20081201

• [Effects of gamma linolenic acid on atherosclerosis induced by cholesterol-rich diet in rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201

• Systems biology: a therapeutic target for tumor therapy.

  Cancer microenvironment : official journal of the International Cancer Microenvironment Society 20081201

• An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS).

  Neuropsychiatric disease and treatment 20081201

• Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy.

  Vascular health and risk management 20081201

• Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma.

  Biologics : targets & therapy 20081201

• Concomitant use of statins and CYP3A4 inhibitors in administrative claims and electronic medical records databases.

  Journal of clinical lipidology 20081201

• Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients.

  Journal of the American College of Cardiology 20081125

• The influence of statin medications on prostate-specific antigen levels.

  Journal of the National Cancer Institute 20081105

• SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice.

  The Journal of clinical investigation 20081103

• Transdermal lovastatin enhances fracture repair in rats.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20081101

• Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-beta-Smad3 pathway.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081101

• Impact of adherence to statins on chronic heart failure in primary prevention.

  British journal of clinical pharmacology 20081101

• Spatial and temporal analysis of pharmaceutical concentrations in the upper Tennessee River basin.

  Chemosphere 20081101

• Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet.

  International journal of obesity (2005) 20081101

• An evaluation of a data mining signal for amyotrophic lateral sclerosis and statins detected in FDA's spontaneous adverse event reporting system.

  Pharmacoepidemiology and drug safety 20081101

• Pleiotropic effect of lovastatin, with and without cholestyramine, in the post coronary artery bypass graft (Post CABG) trial.

  The American journal of cardiology 20081015

• Lovastatin enhances gefitinib activity in glioblastoma cells irrespective of EGFRvIII and PTEN status.

  Journal of neuro-oncology 20081001

• Lovastatin, but not pravastatin, limits in vitro infection due to Coxiella burnetii.

  The Journal of antimicrobial chemotherapy 20081001

• Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins.

  Diabetes 20081001

• AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells.

  Arteriosclerosis, thrombosis, and vascular biology 20081001

• Statins limit Rickettsia conorii infection in cells.

  International journal of antimicrobial agents 20081001

• A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model.

  Innate immunity 20081001

• A gift from nature: the birth of the statins.

  Nature medicine 20081001

• Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

  Current drug metabolism 20081001

• Renal failure and rhabdomyolysis associated with sitagliptin and simvastatin use.

  Diabetic medicine : a journal of the British Diabetic Association 20081001

• Excess coronary artery disease risk in South Asian immigrants: can dysfunctional high-density lipoprotein explain increased risk?

  Vascular health and risk management 20081001

• The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction.

  Vascular health and risk management 20081001

• Frequency of secondary dyslipidemia in obese children.

  Vascular health and risk management 20081001

• Miscellaneous.

  Indian journal of pharmacology 20081001

• Autonomic nervous system and cardiovascular system.

  Indian journal of pharmacology 20081001

• Lovastatin inhibits TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts.

  Investigative ophthalmology & visual science 20080901

• Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention.

  International journal of cancer 20080901

• Utility of a novel Oatp1b2 knockout mouse model for evaluating the role of Oatp1b2 in the hepatic uptake of model compounds.

  Drug metabolism and disposition: the biological fate of chemicals 20080901

• Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins.

  Arteriosclerosis, thrombosis, and vascular biology 20080901

• Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36.

  Diabetes 20080901

• Identification of the specific sequence recognized by Penicillium citrinum MlcR, a GAL4-type transcriptional activator of ML-236B (compactin) biosynthetic genes.

  Fungal genetics and biology : FG & B 20080901

• BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model.

  International journal of oncology 20080901

• Statins induce regulatory T cell recruitment via a CCL1 dependent pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20080901

• Therapy of X-linked adrenoleukodystrophy.

  Expert review of neurotherapeutics 20080901

• Lipid lowering effect of antioxidant alpha-lipoic Acid in experimental atherosclerosis.

  Journal of clinical biochemistry and nutrition 20080901

• HIV infection in the elderly.

  Clinical interventions in aging 20080901

• Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia.

  Clinical interventions in aging 20080901

• Can HMG Co-A reductase inhibitors ('statins') slow the progression of age-related macular degeneration? The age-related maculopathy statin study (ARMSS).

  Clinical interventions in aging 20080901

• Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy.

  International journal of nanomedicine 20080901

• The relationship between obesity and atherosclerotic progression and prognosis among patients with coronary artery bypass grafts the effect of aggressive statin therapy.

  Journal of the American College of Cardiology 20080819

• Mevinolin, citrinin and pigments of adlay angkak fermented by Monascus sp.

  International journal of food microbiology 20080815

• Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition.

  Bioorganic & medicinal chemistry letters 20080815

• Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death.

  Neuroscience letters 20080808

• Detection of Lipitor counterfeits: a comparison of NIR and Raman spectroscopy in combination with chemometrics.

  Journal of pharmaceutical and biomedical analysis 20080805

• Functional coupling of Gs and CFTR is independent of their association with lipid rafts in epithelial cells.

  Pflugers Archiv : European journal of physiology 20080801

• Cholesterol potentiates beta-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress.

  Neurochemical research 20080801

• Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program.

  Clinical pharmacology and therapeutics 20080801

• Lovastatin effect in rat neuroblasts of the CNS: inhibition of cap-dependent translation.

  Journal of neurochemistry 20080801

• Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin.

  Journal of neurochemistry 20080801

• Effects of statins on high-density lipoproteins: a potential contribution to cardiovascular benefit.

  Cardiovascular drugs and therapy 20080801

• Subclinical atherosclerosis: what it is, what it means and what we can do about it.

  International journal of clinical practice 20080801

• Synthesis, DNA binding, and cytotoxic evaluation of new analogs of diallyldisulfide, an active principle of garlic.

  Bioorganic & medicinal chemistry 20080801

• Lipophilicity and cardiovascular outcome in patients with CHF.

  American heart journal 20080801

• Redispersible, dry emulsion of lovastatin protects against intestinal metabolism and improves bioavailability.

  Acta pharmacologica Sinica 20080801

• Synchronization of the cell cycle using lovastatin.

  Cell cycle (Georgetown, Tex.) 20080801

• The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke.

  International journal of stroke : official journal of the International Stroke Society 20080801

• A practical protocol to measure common carotid artery intima-media thickness.

  Clinics (Sao Paulo, Brazil) 20080801

• Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni.

  Memorias do Instituto Oswaldo Cruz 20080801

• [Lovastatin protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis through activation of PI3K/Akt and ERK1/2 signaling pathways].

  Zhonghua xin xue guan bing za zhi 20080801

• Posaconazole in the management of refractory invasive fungal infections.

  Therapeutics and clinical risk management 20080801

• The Relationship Between HIV Infection and Cardiovascular Disease.

  Current cardiology reviews 20080801

• Cloning and characterization of monacolin K biosynthetic gene cluster from Monascus pilosus.

  Journal of agricultural and food chemistry 20080723

• Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins.

  FEBS letters 20080723

• Solubility of lovastatin in a family of six alcohols: Ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, and 1-octanol.

  International journal of pharmaceutics 20080709

• Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells.

  The Journal of nutritional biochemistry 20080701

• Method for comparing the structures of protein ligand-binding sites and application for predicting protein-drug interactions.

  Proteins 20080701

• Efficacy and safety of disodium ascorbyl phytostanol phosphates in men with moderate dyslipidemia.

  European journal of clinical pharmacology 20080701

• Induction of apoptosis in neurofibromatosis type 1 malignant peripheral nerve sheath tumor cell lines by a combination of novel farnesyl transferase inhibitors and lovastatin.

  The Journal of pharmacology and experimental therapeutics 20080701

• Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect.

  Applied microbiology and biotechnology 20080701

• Novel intermolecular iterative mechanism for biosynthesis of mycoketide catalyzed by a bimodular polyketide synthase.

  PLoS biology 20080701

• Rhabdomyolysis and pancreatitis associated with coadministration of danazol 600 mg/d and lovastatin 40 mg/d.

  Clinical therapeutics 20080701

• Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line.

  Experimental cell research 20080610

• Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.

  The Journal of biological chemistry 20080606

• Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease.

  Journal of neurochemistry 20080601

• Atorvastatin and uptake of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) in human monocyte-macrophages: implications for magnetic resonance imaging.

  Biomaterials 20080601

• Impact of the FcgammaII-receptor on quartz uptake and inflammatory response by alveolar macrophages.

  American journal of physiology. Lung cellular and molecular physiology 20080601

• The comparative effectiveness of rosuvastatin vs. other statins in patients with an increased risk of failure to reach NCEP ATP III goal.

  International journal of clinical practice 20080601

• Efficacy of lipid-lowering medications in patients treated with clozapine: a naturalistic study.

  Journal of clinical psychopharmacology 20080601

• Environmental induction of white-opaque switching in Candida albicans.

  PLoS pathogens 20080601

• Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20080601

• Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical.

  The AAPS journal 20080601

• Atorvastatin and cardiovascular risk in the elderly--patient considerations.

  Clinical interventions in aging 20080601

• [Pleiotropic effects of statins].

  Revista medica de Chile 20080601

• [Advance in the study of compounds inducing the expression of heme oxygenase-1].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080601

• The use of fondaparinux for the treatment of venous thromboembolism in a patient with heparin-induced thombocytopenia and thrombosis caused by heparin flushes.

  Therapeutics and clinical risk management 20080601

• Relative safety profiles of high dose statin regimens.

  Vascular health and risk management 20080601

• Can consumers self-select for appropriate use of an over-the-counter statin? The Self Evaluation of Lovastatin to Enhance Cholesterol Treatment Study.

  The American journal of cardiology 20080515

• Zooplankton chitobiase activity as an endpoint of pharmaceutical effect.

  Archives of environmental contamination and toxicology 20080501

• Determination of lovastatin in human plasma by ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry.

  Biomedical chromatography : BMC 20080501

• Histone modifications and chromatin dynamics: a focus on filamentous fungi.

  FEMS microbiology reviews 20080501

• Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.

  Molecular pharmacology 20080501

• Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts.

  Journal of neurochemistry 20080501

• Human urotensin II induces tissue factor and cellular adhesion molecules expression in human coronary endothelial cells: an emerging role for urotensin II in cardiovascular disease.

  Journal of thrombosis and haemostasis : JTH 20080501

• Lovastatin inhibits formation of AA amyloid.

  Journal of leukocyte biology 20080501

• Therapeutic potential of statins in thyroid proliferative disease.

  Nature clinical practice. Endocrinology & metabolism 20080501

• Lovastatin interferes with the infarct size-limiting effect of ischemic preconditioning and postconditioning in rat hearts.

  American journal of physiology. Heart and circulatory physiology 20080501

• Bioconversion of lovastatin to a novel statin by Amycolatopsis sp.

  Applied microbiology and biotechnology 20080501

• Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance.

  Eukaryotic cell 20080501

• Atorvastatin monotherapy vs. combination therapy in the management of patients with combined hyperlipidemia.

  European journal of internal medicine 20080501

• Lovastatin biosynthetic genes of Aspergillus terreus are expressed differentially in solid-state and in liquid submerged fermentation.

  Applied microbiology and biotechnology 20080501

• Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models.

  Oncology reports 20080501

• [Determination of simvastatin in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry].

  Se pu = Chinese journal of chromatography 20080501

• The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson's disease.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080423

• Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression.

  The Journal of biological chemistry 20080418

• The safety of niacin in the US Food and Drug Administration adverse event reporting database.

  The American journal of cardiology 20080417

• The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells.

  Atherosclerosis 20080401

• Cholesterol modulates cellular TGF-beta responsiveness by altering TGF-beta binding to TGF-beta receptors.

  Journal of cellular physiology 20080401

• Regulation of the PTEN promoter by statins and SREBP.

  Human molecular genetics 20080401

• Intracellular cholesterol modifies the ERAD of glucocerebrosidase in Gaucher disease patients.

  Molecular genetics and metabolism 20080401

• Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake.

  Molecular pharmacology 20080401

• Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma.

  American journal of physiology. Lung cellular and molecular physiology 20080401

• Mechanisms of leukocyte migration across the blood-retina barrier.

  Seminars in immunopathology 20080401

• Differential regulation of neutrophil CD18 integrin function by di- and tri-valent cations: manganese vs. gadolinium.

  Annals of biomedical engineering 20080401

• Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells.

  Liver international : official journal of the International Association for the Study of the Liver 20080401

• Lipid levels and low-density lipoprotein cholesterol goal attainment in diabetic patients: rosuvastatin compared with other statins in usual care.

  Expert opinion on pharmacotherapy 20080401

• Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells.

  The American journal of gastroenterology 20080401

• Statins in esophageal cancer cell lines: promising lead?

  The American journal of gastroenterology 20080401

• Statins and cancer risk.

  The American journal of medicine 20080401

• Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo.

  Cancer biology & therapy 20080401

• Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2.

  Cancer research 20080401

• Biphasic effects of atorvastatin on inflammation.

  Pakistan journal of pharmaceutical sciences 20080401

• [Use of statins in children].

  Anales de pediatria (Barcelona, Spain : 2003) 20080401

• Determination of lovastatin hydroxy acid in female B6C3F1 mouse serum.

  Journal of analytical toxicology 20080401

• A multipronged approach to prostate cancer.

  Cancer biology & therapy 20080401

• Pharmacological topics of bone metabolism: antiresorptive microbial compounds that inhibit osteoclast differentiation, function, and survival.

  Journal of pharmacological sciences 20080401

• [Effect of assorted use of Chinese drugs for detoxifying and activating blood circulation on serum high sensitive C-reactive protein in apolipoprotein E gene knock-out mice].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080401

• Combination therapy in cholesterol reduction: focus on ezetimibe and statins.

  Vascular health and risk management 20080401

• Clinical efficacy and safety of statins in managing cardiovascular risk.

  Vascular health and risk management 20080401

• Preferred drug lists: potential impact on healthcare economics.

  Vascular health and risk management 20080401

• Monascus purpureus Went rice in nephrotic hyperlipidemia.

  Indian journal of nephrology 20080401

• Rapid liquid chromatography-tandem mass spectrometry method for the determination of a broad mixture of pharmaceuticals in surface water.

  Journal of chromatography. A 20080328

• Differences in antitumor effects of various statins on human pancreatic cancer.

  International journal of cancer 20080315

• Increased basolateral sorting of carcinoembryonic antigen in a polarized colon carcinoma cell line after cholesterol depletion-Implications for treatment of inflammatory bowel disease.

  World journal of gastroenterology 20080314

• An improved and fully validated LC-MS/MS method for the simultaneous quantification of simvastatin and simvastatin acid in human plasma.

  Journal of pharmaceutical and biomedical analysis 20080313

• Determination of lovastatin in human plasma by ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study.

  Journal of pharmaceutical and biomedical analysis 20080313

• Inhibition of ABC transporters abolishes antimony resistance in Leishmania Infection.

  Antimicrobial agents and chemotherapy 20080301

• Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes.

  The Journal of pharmacology and experimental therapeutics 20080301

• The Food and Drug Administration and over-the-counter statins: an opportunity lost?

  Journal of clinical hypertension (Greenwich, Conn.) 20080301

• Flexible initial dosing of atorvastatin based upon initial low-density lipoprotein cholesterol levels in type 2 diabetic patients.

  The Korean journal of internal medicine 20080301

• Statins impair antitumor effects of rituximab by inducing conformational changes of CD20.

  PLoS medicine 20080301

• Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathways.

  Journal of Alzheimer's disease : JAD 20080301

• [Prescription patterns for antilipidemic drugs in a group of Colombian patients].

  Revista panamericana de salud publica = Pan American journal of public health 20080301

• [Biosynthesis of simvastatin--a mini-review].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20080301

• Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation.

  Journal of neuroscience methods 20080215

• Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway.

  Biochemical pharmacology 20080215

• Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis.

  Journal of neuro-oncology 20080201

• The economic consequences of noncompliance in cardiovascular disease and related conditions: a literature review.

  International journal of clinical practice 20080201

• Class effects of statins in elderly patients with congestive heart failure: a population-based analysis.

  American heart journal 20080201

• New developments in medulloblastoma treatment: the potential of a cyclopamine-lovastatin combination.

  Expert opinion on investigational drugs 20080201

• Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours.

  Leukemia & lymphoma 20080201

• Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells.

  Biological & pharmaceutical bulletin 20080201

• Pharmacokinetics and bioequivalence study of two tablet formulations of lovastatin in healthy volunteers.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20080201

• Red yeast rice and omega-3 fatty acids for cholesterol management.

  South Dakota medicine : the journal of the South Dakota State Medical Association 20080201

• Update on the use of fibrates: focus on bezafibrate.

  Vascular health and risk management 20080201

• Perioperative use of statins in noncardiac surgery.

  Vascular health and risk management 20080201

• High density lipoprotein cholesterol: an evolving target of therapy in the management of cardiovascular disease.

  Vascular health and risk management 20080201

• The real code of leonardo da vinci.

  Current cardiology reviews 20080201

• Comparing pharmacokinetic and pharmacodynamic profiles in female rats orally exposed to lovastatin by gavage versus diet.

  Chemico-biological interactions 20080130

• The association between statins and cancer incidence in a veterans population.

  Journal of the National Cancer Institute 20080116

• Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors.

  Biochemical pharmacology 20080115

• FDA advisers again reject nonprescription lovastatin.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080115

• Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells.

  Biochemical and biophysical research communications 20080111

• Lovastatin protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt and ERK1/2.

  Journal of cellular biochemistry 20080101

• Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080101

• Hydrophobic but not hydrophilic statins enhance phagocytosis and decrease apoptosis of human peripheral blood cells in vitro.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080101

• Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of jasmonate, ethylene and calcium signaling.

  Planta 20080101

• Screening statins for possible carcinogenic risk: up to 9 years of follow-up of 361,859 recipients.

  Pharmacoepidemiology and drug safety 20080101

• Pancreatic stellate cells: new target in the treatment of chronic pancreatitis.

  Journal of gastroenterology and hepatology 20080101

• Statin use and risk of breast cancer.

  Cancer 20080101

• In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent.

  Lung 20080101

• Lovastatin inhibits oxidized low-density lipoprotein-induced plasminogen activator inhibitor and transforming growth factor-beta1 expression via a decrease in Ras/extracellular signal-regulated kinase activity in mesangial cells.

  Translational research : the journal of laboratory and clinical medicine 20080101

• Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet.

  Metabolism: clinical and experimental 20080101

• Ciglitazone, an agonist of peroxisome proliferator-activated receptor gamma, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin.

  International journal of oncology 20080101

• Effects of lovastatin alone or combined with irradiation on tumor cells in vitro and in vivo.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20080101

• The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells.

  BMC cancer 20080101

• Statin induces apoptosis and cell growth arrest in prostate cancer cells.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080101

• Incidence of adverse events with HMG-CoA reductase inhibitors in liver transplant patients.

  Clinical transplantation 20080101

• Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi.

  Genome biology 20080101

• Cell cycle and cell death are not necessary for appressorium formation and plant infection in the fungal plant pathogen Colletotrichum gloeosporioides.

  BMC biology 20080101

• Peroxisome proliferator activated receptors and lipoprotein metabolism.

  PPAR research 20080101

• Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor.

  BMC evolutionary biology 20080101

• Frequency and clinical relevance of drug interactions with lovastatin and simvastatin: an observational database study.

  Drug safety 20080101

• Does productivity influence priority setting? A case study from the field of CVD prevention.

  Cost effectiveness and resource allocation : C/E 20080101

• [New approaches to the drug prophylaxis of mammary tumor: evaluation of the prophylactic effect of lovastatin and captopril in rats with experimental mammary gland tumors].

  Eksperimental'naia i klinicheskaia farmakologiia 20080101

• Hepatic effects of lovastatin exposure in patients with liver disease: a retrospective cohort study.

  Drug safety 20080101

• The Lipid lowering and Onset of Renal Disease (LORD) Trial: a randomized double blind placebo controlled trial assessing the effect of atorvastatin on the progression of kidney disease.

  BMC nephrology 20080101

• Fosamprenavir or atazanavir once daily boosted with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT.

  AIDS research and therapy 20080101

• Chinese red yeast rice (Monascus purpureus-fermented rice) promotes bone formation.

  Chinese medicine 20080101

• Analysis of Aspergillus nidulans metabolism at the genome-scale.

  BMC genomics 20080101

• Changes in cholesterol kinetics following sugar cane policosanol supplementation: a randomized control trial.

  Lipids in health and disease 20080101

• Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas.

  Molecular cancer 20080101

• Interaction of the HMG-CoA reductase inhibitor lovastatin and nitric oxide in cardiomyocyte cell death.

  Pharmacology 20080101

• A Role for the PPARgamma in Cancer Therapy.

  PPAR research 20080101

• Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.

  Clinical pharmacokinetics 20080101

• Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways.

  PloS one 20080101

• Mitochondria, PPARs, and Cancer: Is Receptor-Independent Action of PPAR Agonists a Key?

  PPAR research 20080101

• Secondary prevention of coronary heart disease in elderly patients following myocardial infarction: are all HMG-CoA reductase inhibitors alike?

  Drugs & aging 20080101

• Modelling neurofibromatosis type 1 tibial dysplasia and its treatment with lovastatin.

  BMC medicine 20080101

• Statins, bone, and neurofibromatosis type 1.

  BMC medicine 20080101

• Yeast cell factories for fine chemical and API production.

  Microbial cell factories 20080101

• 15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases.

  Journal of inflammation (London, England) 20080101

• Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats.

  BMC pharmacology 20080101

• Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells.

  PPAR research 20080101

• Use of rosiglitazone before and after vascular injury in hypercholesterolemic rabbits: Assessment of neointimal formation.

  Thrombosis journal 20080101

• Effects of krill oil on serum lipids of hyperlipidemic rats and human SW480 cells.

  Lipids in health and disease 20080101

• Influence of sodium monoketocholate on the hypolipidemic activity of lovastatin in healthy and diabetic rats.

  European journal of drug metabolism and pharmacokinetics 20080101

• PPARgamma: The Portrait of a Target Ally to Cancer Chemopreventive Agents.

  PPAR research 20080101

• Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells.

  BMC biology 20080101

• Non-healing painful ulcers in a patient with chronic kidney disease and role of sodium thiosulfate: a case report.

  Cases journal 20080101

• Unlocking the power of cross-species genomic analyses: identification of evolutionarily conserved breast cancer networks and validation of preclinical models.

  Breast cancer research : BCR 20080101

• Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20080101

• The prince and the pauper. A tale of anticancer targeted agents.

  Molecular cancer 20080101

• In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.

  BMC bioinformatics 20080101

• Net efficacy adjusted for risk (NEAR): a simple procedure for measuring risk:benefit balance.

  PloS one 20080101

• Implementing shared decision-making in nutrition clinical practice: a theory-based approach and feasibility study.

  Implementation science : IS 20080101

• The effects of lovastatin on conventional medical treatment of lower urinary tract symptoms with finasteride.

  International braz j urol : official journal of the Brazilian Society of Urology 20080101

• Dynamical modeling of the cholesterol regulatory pathway with Boolean networks.

  BMC systems biology 20080101

• Defective rotavirus particle assembly in lovastatin-treated MA104 cells.

  Archives of virology 20080101

• Design of floating bilayer tablets of diltiazem hydrochloride and lovastatin.

  PDA journal of pharmaceutical science and technology 20080101

• Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors.

  PPAR research 20080101

• PPARgamma, PTEN, and the Fight against Cancer.

  PPAR research 20080101

• Clinical Use of PPARgamma Ligands in Cancer.

  PPAR research 20080101

• Oxidative imbalance in nonstimulated X-adrenoleukodystrophy-derived lymphoblasts.

  Developmental neuroscience 20080101

• HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi.

  Studies in mycology 20080101

• Statin treatment, carotid atherosclerotic plaque macrophage infiltration and circulating inflammatory markers.

  The open cardiovascular medicine journal 20080101

• Sphincter of Oddi and its dysfunction.

  Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20080101

• Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry.

  Analytical chemistry insights 20080101

• Microbial production and biomedical applications of lovastatin.

  Indian journal of pharmaceutical sciences 20080101

• Frequency and predictors of tablet splitting in statin prescriptions: a population-based analysis.

  Open medicine : a peer-reviewed, independent, open-access journal 20080101

• A simple and rapid approach for removing citrinin while retaining monacolin K in red mold rice.

  Journal of agricultural and food chemistry 20071226

• The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.

  The Journal of clinical investigation 20071203

• Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants.

  The British journal of nutrition 20071201

• Simultaneous biosynthesis of (+)-geodin by a lovastatin-producing fungus Aspergillus terreus.

  Journal of biotechnology 20071201

• Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells.

  Lipids 20071201

• Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways.

  Plant cell reports 20071201

• P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors.

  Experimental hematology 20071201

• Hypolipidemic and antioxidant effects of ethanolic extract from dried calyx of Hibiscus sabdariffa in alloxan-induced diabetic rats.

  Fundamental & clinical pharmacology 20071201

• The antitumour activities of statins.

  Current oncology (Toronto, Ont.) 20071201

• Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma.

  Molecular cancer therapeutics 20071201

• Understanding practice patterns and low-density lipoprotein cholesterol goal attainment implications of switching patients from simvastatin in a health plan setting.

  The American journal of managed care 20071201

• 3-hydroxy-3-methylglutaryl coenzyme a reductase 1 interacts with NORK and is crucial for nodulation in Medicago truncatula.

  The Plant cell 20071201

• Aliskiren--an orally active renin inhibitor. Review of pharmacology, pharmacodynamics, kinetics, and clinical potential in the treatment of hypertension.

  Vascular health and risk management 20071201

• The antioxidant effect of lovastatin on phagocyte-induced DNA damage: implications for cancer prevention.

  Journal of experimental & clinical cancer research : CR 20071201

• [Protection of vascular endothelial cells from ox-LDL induced injury by protocatechualdehyde].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071201

• Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions.

  Current neuropharmacology 20071201

• Structural elucidation of an unknown Simvastatin by-product in industrial synthesis starting from Lovastatin.

  Journal of pharmaceutical and biomedical analysis 20071130

• The impact of generic reference pricing interventions in the statin market.

  Health policy (Amsterdam, Netherlands) 20071101

• Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid beta-infused rat by repressing amyloid beta accumulation.

  Journal of neuroscience research 20071101

• Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells.

  Endocrinology 20071101

• Lovastatin induces the expression of bradykinin type 2 receptors in cultured human coronary artery endothelial cells.

  Journal of molecular and cellular cardiology 20071101

• Effect of combining viscous fibre with lovastatin on serum lipids in normal human subjects.

  International journal of clinical practice 20071101

• Effects of vitamin E on cholesterol levels of hypercholesterolemic patients receiving statins.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071101

• Cholesterol-lowering drugs and prostate cancer risk: a population-based case-control study.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20071101

• Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro.

  Molecular cancer therapeutics 20071101

• Comparative evaluation of the effects of statins on human stem and cancer cells in vitro.

  Reproductive biomedicine online 20071101

• Antifungal activity of statins against Aspergillus species.

  Medical mycology 20071101

• Titration patterns with rosuvastatin as compared with other statins in clinical practice: a retrospective observational cohort study using an electronic medical record database.

  Clinical therapeutics 20071101

• Comparison of a statin vs. hypolipemic diet on the oxidant status in hemodialyzed patients with chronic renal failure.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071101

• Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis.

  Journal of cell science 20071015

• Activation of the integrated stress response regulates lovastatin-induced apoptosis.

  The Journal of biological chemistry 20071012

• Locally delivered lovastatin nanoparticles enhance fracture healing in rats.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20071001

• Risk of congenital anomalies in pregnant users of statin drugs.

  British journal of clinical pharmacology 20071001

• Salicylic acid-induced taxol production and isopentenyl pyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei.

  Cell biology international 20071001

• Growth hormone (GH) replacement decreases serum total and LDL-cholesterol in hypopituitary patients on maintenance HMG CoA reductase inhibitor (statin) therapy.

  Clinical endocrinology 20071001

• P-glycoprotein has differential effects on the disposition of statin acid and lactone forms in mdr1a/b knockout and wild-type mice.

  Drug metabolism and disposition: the biological fate of chemicals 20071001

• ICAM-1 peptide inhibitors of T-cell adhesion bind to the allosteric site of LFA-1. An NMR characterization.

  Chemical biology & drug design 20071001

• Effectiveness of statins in Medicare-eligible patients and patients < 65 years using clinical practice data.

  International journal of clinical practice 20071001

• The road to LOAD: late-onset Alzheimer's disease and a possible way to block it.

  Expert opinion on therapeutic targets 20071001

• The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway.

  Gastroenterology 20071001

• Life style-related diseases of the digestive system: cell culture system for the screening of anti-hepatitis C virus (HCV) reagents: suppression of HCV replication by statins and synergistic action with interferon.

  Journal of pharmacological sciences 20071001

• A meta-analysis to evaluate the efficacy of statins in children with familial hypercholesterolemia.

  International journal of clinical pharmacology and therapeutics 20071001

• Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.

  Journal of cardiovascular pharmacology 20071001

• The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation.

  Vascular health and risk management 20071001

• Cholesterol lowering for secondary prevention: what statin dose should we use?

  Vascular health and risk management 20071001

• Colesevelam hydrochloride: reducing atherosclerotic coronary heart disease risk factors.

  Vascular health and risk management 20071001

• Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration.

  Toxicology and applied pharmacology 20070915

• Statins reduce amyloid-beta production through inhibition of protein isoprenylation.

  The Journal of biological chemistry 20070914

• Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells.

  European journal of pharmacology 20070910

• Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070901

• A phase I study to assess the safety and activity of topical lovastatin (FP252S) for the prevention of chemotherapy-induced alopecia.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20070901

• Statins prevent cholinesterase inhibitor blockade of sympathetic alpha7-nAChR-mediated currents in rat superior cervical ganglion neurons.

  American journal of physiology. Heart and circulatory physiology 20070901

• The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet.

  Biopharmaceutics & drug disposition 20070901

• Effect of statin and angiotensin-converting enzyme inhibition on structural and hemodynamic alterations in autosomal dominant polycystic kidney disease model.

  American journal of physiology. Renal physiology 20070901

• Effectiveness of rosuvastatin in low-density lipoprotein cholesterol lowering and National Cholesterol Education Program Adult Treatment Panel guideline III LDL-C goal attainment compared to other statins among diabetes mellitus patients: a retrospective study using an electronic medical records dataset in the United States.

  Current medical research and opinion 20070901

• Lovastatin enhances phenylbutyrate-induced MR-visible glycerophosphocholine but not apoptosis in DU145 prostate cells.

  Biochimica et biophysica acta 20070901

• A new perspective on nonprescription statins: an opportunity for patient education and involvement.

  The American journal of cardiology 20070901

• Optimization of production of monacolin K from gamma-irradiated Monascus mutant by use of response surface methodology.

  Journal of medicinal food 20070901

• Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice.

  The American journal of geriatric pharmacotherapy 20070901

• Ask the doctor. I saw a newspaper column that said red yeast rice is a safer, more effective way to treat high cholesterol than statin drugs. Is that true?

  Harvard heart letter : from Harvard Medical School 20070901

• The molecular genetics of breast cancer and targeted therapy.

  Biologics : targets & therapy 20070901

• Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation.

  Veterinary microbiology 20070831

• Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease.

  Neurology 20070828

• Red mold dioscorea has greater hypolipidemic and antiatherosclerotic effect than traditional red mold rice and unfermented dioscorea in hamsters.

  Journal of agricultural and food chemistry 20070822

• Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation.

  Biochemical pharmacology 20070815

• Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition.

  Journal of agricultural and food chemistry 20070808

• Chemotherapy and zoledronate sensitize solid tumour cells to Vgamma9Vdelta2 T cell cytotoxicity.

  Cancer immunology, immunotherapy : CII 20070801

• Statins in elderly patients with acute coronary syndrome: an analysis of dose and class effects in typical practice.

  Heart (British Cardiac Society) 20070801

• Effect of reduced levels of the LDL receptor of Ehrlich ascites tumor cells on cholesterol uptake and cell proliferation: a coculture study with baby hamster kidney cells.

  Cell biology international 20070801

• Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid.

  Drug metabolism and disposition: the biological fate of chemicals 20070801

• Simvastatin inhibits IFN-gamma-induced CD40 gene expression by suppressing STAT-1alpha.

  Journal of leukocyte biology 20070801

• Establishing the benefit of statins in low-to-moderate--risk primary prevention: the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS).

  Atherosclerosis. Supplements 20070801

• On the factors modulating the effect of statins on malignant cell proliferation.

  Cancer investigation 20070801

• Impact of statin dosing intensity on transaminase and creatine kinase.

  The American journal of medicine 20070801

• Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.

  PLoS pathogens 20070801

• Prolonged-release nicotinic acid for the management of dyslipidemia: an update including results from the NAUTILUS study.

  Vascular health and risk management 20070801

• Review of tipranavir in the treatment of drug-resistant HIV.

  Therapeutics and clinical risk management 20070801

• Evaluation of patient care interventions and recommendations by a transitional care pharmacist.

  Therapeutics and clinical risk management 20070801

• Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.

  Journal of the American College of Cardiology 20070731

• Lack of evidence of a clopidogrel-statin interaction in the CHARISMA trial.

  Journal of the American College of Cardiology 20070724

• A macrokinetic modelling of the biosynthesis of lovastatin by Aspergillus terreus.

  Journal of biotechnology 20070715

• Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as farnesyltransferase inhibitors.

  Journal of medicinal chemistry 20070712

• Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer.

  The Journal of biological chemistry 20070706

• Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury.

  Life sciences 20070704

• Esterase inhibition attribute of grapefruit juice leading to a new drug interaction.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

  The Journal of pharmacology and experimental therapeutics 20070701

• Esterase inhibition by grapefruit juice flavonoids leading to a new drug interaction.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma.

  Journal of lipid research 20070701

• Rac1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus.

  FEMS microbiology letters 20070701

• Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells.

  European journal of cell biology 20070701

• Improving simvastatin bioconversion in Escherichia coli by deletion of bioH.

  Metabolic engineering 20070701

• Effects of lactose and glucose on production of itaconic acid and lovastatin by Aspergillus terreus ATCC 20542.

  Journal of bioscience and bioengineering 20070701

• What do medical records tell us about potentially harmful co-prescribing?

  Joint Commission journal on quality and patient safety 20070701

• Chromatography-mass spectrometry methods for the quantitation of statins in biological samples.

  Journal of pharmaceutical and biomedical analysis 20070628

• Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatin therapy.

  Investigational new drugs 20070601

• Modulation of COX-2 expression by statins in human monocytic cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070601

• Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition.

  American journal of respiratory cell and molecular biology 20070601

• Effects of statins on bone mineral density: a meta-analysis of clinical studies.

  Bone 20070601

• Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovB.

  The FEBS journal 20070601

• Potentiated antitumor effects of the combination treatment with statins and pamidronate in vitro and in vivo.

  International journal of oncology 20070601

• German evidence-based guidelines for the treatment of Psoriasis vulgaris (short version).

  Archives of dermatological research 20070601

• Lovastatin effects on bone mineral density in postmenopausal women with type 2 diabetes mellitus.

  Acta diabetologica 20070601

• Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma.

  Molecular cancer therapeutics 20070601

• Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans.

  PLoS pathogens 20070601

• [Experimental study of anti-atherosclerosis potency by lycium seed oil and its possible mechanism].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070601

• Studies on free radicals, antioxidants, and co-factors.

  Clinical interventions in aging 20070601

• Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.

  Blood 20070515

• Interactions between statins and Penicillium chrysogenum antifungal protein (PAF) to inhibit the germination of sporangiospores of different sensitive Zygomycetes.

  FEMS microbiology letters 20070501

• Effects of statins on alpha7 nicotinic receptor, cholinesterase and alpha-form of secreted amyloid precursor peptide in SH-SY5Y cells.

  Neurochemistry international 20070501

• Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity.

  Heart rhythm 20070501

• Effect of HMGCoA reductase inhibitors on cytochrome P450 expression in endothelial cell line.

  Journal of cardiovascular pharmacology 20070501

• In vitro study of lovastatin interactions with amiodarone and with carbon tetrachloride in isolated rat hepatocytes.

  World journal of gastroenterology 20070421

• Beneficial effect of statins in multiple sclerosis: is it dose-dependent?

  Atherosclerosis 20070401

• Partial silencing of a hydroxy-methylglutaryl-CoA reductase-encoding gene in Trichoderma harzianum CECT 2413 results in a lower level of resistance to lovastatin and lower antifungal activity.

  Fungal genetics and biology : FG & B 20070401

• Synthesis and biological evaluation of unprecedented classes of spiro-beta-lactams and azido-beta-lactams as acyl-CoA:cholesterol acyltransferase inhibitors.

  Bioorganic & medicinal chemistry letters 20070401

• Stacking and quantitative analysis of lovastatin in urine samples by the transient moving chemical reaction boundary method in capillary electrophoresis.

  Analytical and bioanalytical chemistry 20070401

• The effect of aggressive versus conventional lipid-lowering therapy on markers of inflammatory and oxidative stress.

  Cardiovascular drugs and therapy 20070401

• Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.

  Nature chemical biology 20070401

• Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo.

  Experimental biology and medicine (Maywood, N.J.) 20070401

• [Lovastatin induction of the redundant gene: implications for therapy of X-linked adrenoleukodystrophy].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20070401

• The potential antioxidant capacity and angiotensin I-converting enzyme inhibitory activity of Monascus-fermented soybean extracts: evaluation of Monascus-fermented soybean extracts as multifunctional food additives.

  Journal of food science 20070401

• Effect of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors and antioxidant vitamins on free radical lipid oxidation in rat liver.

  Bulletin of experimental biology and medicine 20070401

• Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine.

  Veterinary microbiology 20070310

• [The neurobiology of learning difficulties: neurofibromatosis type 1 as a model for researching and treating learning disorders].

  Revista de neurologia 20070302

• Role of microglia in the pathogenesis of osmotic-induced demyelination.

  Experimental neurology 20070301

• Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling.

  The Journal of physiology 20070301

• Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.

  Drug metabolism and disposition: the biological fate of chemicals 20070301

• Treatment of experimental autoimmune uveoretinitis with atorvastatin and lovastatin.

  Experimental eye research 20070301

• Predicting the oxidative metabolism of statins: an application of the MetaSite algorithm.

  Pharmaceutical research 20070301

• High-dose methylprednisolone influences the physiology and virulence of Candida albicans ambiguously and enhances the candidacidal activity of the polyene antibiotic amphotericin B and the superoxide-generating agent menadione.

  FEMS yeast research 20070301

• Lovastatin attenuates nerve injury in an animal model of Guillain-Barré syndrome.

  Journal of neurochemistry 20070301

• Functional analysis of the hepatic HMG-CoA reductase promoter by in vivo electroporation.

  Experimental biology and medicine (Maywood, N.J.) 20070301

• Preparation, characterization, and in vitro and in vivo evaluation of lovastatin solid lipid nanoparticles.

  AAPS PharmSciTech 20070301

• Neuropsychiatric consequences of cardiovascular medications.

  Dialogues in clinical neuroscience 20070301

• C/T conversion alters interleukin-1A promoter function in a human astrocyte cell line.

  Life sciences 20070227

• Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin.

  The Journal of biological chemistry 20070223

• Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.

  Biochemical and biophysical research communications 20070223

• Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation.

  The Journal of biological chemistry 20070216

• Targeting EGF-receptor-signalling in squamous cell carcinomas of the head and neck.

  British journal of cancer 20070212

• Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells.

  Biochemical and biophysical research communications 20070202

• Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling.

  Neuroscience letters 20070202

• Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts.

  The pharmacogenomics journal 20070201

• Effect of a statin on an in vitro model of endometriosis.

  Fertility and sterility 20070201

• Decrease of cholesterol in mouse melanoma causes secretion of lysosomal enzymes.

  Journal of biochemistry 20070201

• Lovastatin insensitive 1, a Novel pentatricopeptide repeat protein, is a potential regulatory factor of isoprenoid biosynthesis in Arabidopsis.

  Plant & cell physiology 20070201

• Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity.

  Annals of surgery 20070201

• The use of statins in postoperative adhesion prevention.

  Annals of surgery 20070201

• c-Jun N-terminal protein kinase signalling pathway mediates lovastatin-induced rat brain neuroblast apoptosis.

  Biochimica et biophysica acta 20070201

• Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system).

  The American journal of cardiology 20070201

• Exenatide effects on statin pharmacokinetics and lipid response.

  International journal of clinical pharmacology and therapeutics 20070201

• Estimating the impact of adding C-reactive protein as a criterion for lipid lowering treatment in the United States.

  Journal of general internal medicine 20070201

• Meta-analysis of drug-induced adverse events associated with intensive-dose statin therapy.

  Clinical therapeutics 20070201

• Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels.

  Vascular health and risk management 20070201

• Lovastatin and cyclopamine combination in medulloblastoma.

  Cancer biology & therapy 20070201

• Production of dihydroisocoumarins in Fusarium verticillioides by swapping ketosynthase domain of the fungal iterative polyketide synthase Fum1p with that of lovastatin diketide synthase.

  Journal of the American Chemical Society 20070110

• Critical role for FoxO3a-dependent regulation of p21CIP1/WAF1 in response to statin signaling in cardiac myocytes.

  Circulation research 20070105

• Quantitative analysis of lovastatin in capsule of Chinese medicine monascus by capillary zone electrophoresis with UV-vis detector.

  Journal of pharmaceutical and biomedical analysis 20070104

• Syntheses of conjugated pyrones for the enzymatic assay of lovastatin nonaketide synthase, an iterative polyketide synthase.

  Organic letters 20070104

• Herpes zoster-associated acute urinary retention: a case report.

  International urogynecology journal and pelvic floor dysfunction 20070101

• Supplementation of the cultivation media with B-group vitamins enhances lovastatin biosynthesis by Aspergillus terreus.

  Journal of biotechnology 20070101

• Phenantroline, lovastatin, and mebendazole do not inhibit oviposition in the murine experimental infection with Angiostrongylus costaricensis.

  Parasitology research 20070101

• Lovastatin inhibits the extracellular-signal-regulated kinase pathway in immortalized rat brain neuroblasts.

  The Biochemical journal 20070101

• In silico prediction of pregnane X receptor activators by machine learning approaches.

  Molecular pharmacology 20070101

• Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology.

  Applied microbiology and biotechnology 20070101

• Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.

  The Journal of pharmacology and experimental therapeutics 20070101

• Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment.

  Molecular pharmacology 20070101

• Influences of lovastatin on membrane ion flow and intracellular signaling in breast cancer cells.

  Cellular & molecular biology letters 20070101

• Therapeutic approach to FSGS in children.

  Pediatric nephrology (Berlin, Germany) 20070101

• Apolipoprotein E genotype affects the response to lipid-lowering therapy in Chinese patients with type 2 diabetes mellitus.

  Diabetes, obesity & metabolism 20070101

• Hedgehog signaling promotes medulloblastoma survival via Bc/II.

  The American journal of pathology 20070101

• Optimal low-density lipoprotein cholesterol lowering--morning versus evening statin administration.

  The Annals of pharmacotherapy 20070101

• Probable statin-induced testicular pain.

  The Annals of pharmacotherapy 20070101

• [Regulatory effect of Chinese herbal compound for detoxifying and activating blood circulation on expression of NF-kappaB and MMP-9 in aorta of apolipoprotein E gene knocked-out mice].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070101

• Cost-effectiveness of medical interventions to prevent cardiovascular disease in a sub-Saharan African country--the case of Tanzania.

  Cost effectiveness and resource allocation : C/E 20070101

• Chemical combination effects predict connectivity in biological systems.

  Molecular systems biology 20070101

• The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases.

  Immunity & ageing : I & A 20070101

• How equitable are GP practice prescribing rates for statins?: an ecological study in four primary care trusts in North West England.

  International journal for equity in health 20070101

• The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention.

  Molecular cancer 20070101

• The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects.

  Lipids in health and disease 20070101

• Risk and predictability of drug interactions in the elderly.

  International review of neurobiology 20070101

• Physicochemical characterization and dissolution study of solid dispersions of Lovastatin with polyethylene glycol 4000 and polyvinylpyrrolidone K30.

  Pharmaceutical development and technology 20070101

• Statins disrupt CCR5 and RANTES expression levels in CD4(+) T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1.

  PloS one 20070101

• Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir.

  Journal of the American Board of Family Medicine : JABFM 20070101

• Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease.

  BMC medicine 20070101

• Mevastatin increases eNO synthase expression and inhibits lipid peroxidation in human endothelial cells.

  Clinical hemorheology and microcirculation 20070101

• Reduction of protein synthesis and statin-induced cardiomyocyte cell death.

  Cardiovascular toxicology 20070101

• General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs.

  Clinical pharmacokinetics 20070101

• HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells.

  Journal of vascular research 20070101

• Should we encourage over-the-counter statins? A population perspective for coronary heart disease prevention.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101

• Regression or reduction in progression of atherosclerosis, and avoidance of coronary events, with lovastatin in patients with or at high risk of cardiovascular disease: a review.

  Clinical drug investigation 20070101

• An integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome data.

  BMC pharmacology 20070101

• The Role of PPARs in Lung Fibrosis.

  PPAR research 20070101

• Determination of pitavastatin in human plasma via HPLC-ESI-MS/MS and subsequent application to a clinical study in healthy Chinese volunteers.

  Clinica chimica acta; international journal of clinical chemistry 20070101

• The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data.

  Genome biology 20070101

• Locally applied Simvastatin improves fracture healing in mice.

  BMC musculoskeletal disorders 20070101

• Monascus rice products.

  Advances in food and nutrition research 20070101

• Dissecting complex transcriptional responses using pathway-level scores based on prior information.

  BMC bioinformatics 20070101

• Increased expression of CD14 in macrophages after inhibition of the cholesterol biosynthetic pathway by lovastatin.

  Molecular medicine (Cambridge, Mass.) 20070101

• Fish-oil esters of plant sterols differ from vegetable-oil sterol esters in triglycerides lowering, carotenoid bioavailability and impact on plasminogen activator inhibitor-1 (PAI-1) concentrations in hypercholesterolemic subjects.

  Lipids in health and disease 20070101

• Medicinal importance of grapefruit juice and its interaction with various drugs.

  Nutrition journal 20070101

• Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line.

  BMC cancer 20070101

• Manipulation of hedgehog signaling in Xenopus by means of embryo microinjection and application of chemical inhibitors.

  Methods in molecular biology (Clifton, N.J.) 20070101

• The Ontario printed educational message (OPEM) trial to narrow the evidence-practice gap with respect to prescribing practices of general and family physicians: a cluster randomized controlled trial, targeting the care of individuals with diabetes and hypertension in Ontario, Canada.

  Implementation science : IS 20070101

• Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: a preliminary report.

  Lipids in health and disease 20070101

• A critical gap between recommended and achieved LDL-cholesterol levels. Results of statin therapy in Slovakia.

  Bratislavske lekarske listy 20070101

• Peroxisome proliferator-activated receptors in lung cancer.

  PPAR research 20070101

• Effect of Coenzyme Q10 and green tea on plasma and liver lipids, platelet aggregation, TBARS production and erythrocyte Na leak in simvastatin treated hypercholesterolmic rats.

  Nutrition research and practice 20070101

• Elevated K-ras activity with cholestyramine and lovastatin, but not konjac mannan or niacin in lung--importance of mouse strain.

  Biochemical pharmacology 20061215

• Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors.

  European journal of pharmacology 20061215

• Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21.

  British journal of cancer 20061204

• Osteogenic gene expression decreases in stromal cells of patients with osteonecrosis.

  Clinical orthopaedics and related research 20061201

• Colchicine and HMG Co-A reductase inhibitors induced myopathy-a case report.

  Neurotoxicology 20061201

• Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide.

  British journal of pharmacology 20061201

• Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway.

  Oncology reports 20061201

• Lovastatin possesses a fungistatic effect against Candida albicans, but does not trigger apoptosis in this opportunistic human pathogen.

  FEMS yeast research 20061201

• Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets.

  Current cancer drug targets 20061201

• Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance.

  Clinical pharmacology and therapeutics 20061201

• Regulation of hepatic cholesterol metabolism in CETP/LDLr mice by cholesterol feeding and by drugs (cholestyramine and lovastatin) that lower plasma cholesterol.

  Clinical and experimental pharmacology & physiology 20061201

• Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypothalamic metastases.

  Thyroid : official journal of the American Thyroid Association 20061201

• Lipid lowering inefficacy of high-dose statin therapy due to concurrent use of phenytoin.

  Southern medical journal 20061201

• Who should receive a statin drug to lower cardiovascular risk? Does the drug and the dose of the drug matter?

  Vascular health and risk management 20061201

• Phenotypic conversion leads to structural and functional changes of smooth muscle sarcolemma.

  Experimental cell research 20061101

• HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway.

  Journal of molecular medicine (Berlin, Germany) 20061101

• Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome.

  The Journal of clinical endocrinology and metabolism 20061101

• Plasma cholesterol is hyperresponsive to statin in ABCG5/ABCG8 transgenic mice.

  Hepatology (Baltimore, Md.) 20061101

• Role of P-glycoprotein in statin drug interactions.

  Pharmacotherapy 20061101

• Statins, fibrates, and melanoma risk: a systematic review and meta-analysis.

  Journal of the National Cancer Institute 20061101

• Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.

  Chemistry & biology 20061101

• Distribution of lovastatin to bone and its effect on bone turnover in rats.

  The Journal of pharmacy and pharmacology 20061101

• Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms.

  The Biochemical journal 20061015

• Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin.

  Applied microbiology and biotechnology 20061001

• Influence of cholesterol and lovastatin on alpha-form of secreted amyloid precursor protein and expression of alpha7 nicotinic receptor on astrocytes.

  Neurochemistry international 20061001

• Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions.

  Pharmacology & therapeutics 20061001

• Neopterin induces pro-atherothrombotic phenotype in human coronary endothelial cells.

  Journal of thrombosis and haemostasis : JTH 20061001

• Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells.

  Molecular reproduction and development 20061001

• The role of geranylgeranylated proteins in human mesangial cell proliferation.

  Kidney international 20061001

• Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway.

  Fertility and sterility 20061001

• Cost efficiency and formulary considerations for statin therapy.

  The American journal of managed care 20061001

• Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia.

  Neuropeptides 20061001

• MUBs, a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation.

  The Journal of biological chemistry 20060915

• An automated blood sampling system to measure lovastatin level in plasma and faeces.

  Biomedical chromatography : BMC 20060901

• The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901

• Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis.

  The American journal of pathology 20060901

• Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.

  The Journal of clinical investigation 20060901

• Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells.

  Molecular cancer therapeutics 20060901

• Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells.

  Purinergic signalling 20060901

• Proteomic analysis of Caco-2 cells treated with monacolin K.

  Journal of agricultural and food chemistry 20060823

• Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation.

  Human molecular genetics 20060815

• Herbicidal effects of statin pharmaceuticals in Lemna gibba.

  Environmental science & technology 20060815

• Roles of endogenously synthesized sterols in the endocytic pathway.

  The Journal of biological chemistry 20060811

• Cholesterol deficiency perturbs actin signaling and glutamate homeostasis in hippocampal astrocytes.

  Brain research 20060809

• Screening of compactin-resistant microorganisms capable of converting compactin to pravastatin.

  Current microbiology 20060801

• Clinical inquiries. Which medications can be split without compromising efficacy and safety?

  The Journal of family practice 20060801

• Effect of red mold rice supplements on serum and meat cholesterol levels of broilers chicken.

  Applied microbiology and biotechnology 20060801

• Statins in the treatment of chronic heart failure: a systematic review.

  PLoS medicine 20060801

• Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer.

  Urologic nursing 20060801

• [Protective effect of effective parts of Zingiber Offecinal on vascular endothelium of the experimental hyperlipidemic rats].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060801

• Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060715

• Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin.

  Journal of molecular biology 20060707

• Inhibitory effects of statins on human monocarboxylate transporter 4.

  International journal of pharmaceutics 20060706

• Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.

  International journal of cancer 20060701

• A comparative study on the antimutagenicity of atorvastatin and lovastatin against directly acting mutagens.

  Cell biology and toxicology 20060701

• Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis.

  Annals of neurology 20060701

• Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.

  Biochimica et biophysica acta 20060701

• Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20060701

• Cyclodextrins but not compactin inhibit the lateral diffusion of membrane proteins independent of cholesterol.

  Traffic (Copenhagen, Denmark) 20060701

• Different anti-HCV profiles of statins and their potential for combination therapy with interferon.

  Hepatology (Baltimore, Md.) 20060701

• Persistence and adherence to cholesterol lowering agents: evidence from Régie de l'Assurance Maladie du Québec data.

  American heart journal 20060701

• Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury.

  Journal of neuropathology and experimental neurology 20060701

• Study on the conversion of three natural statins from lactone forms to their corresponding hydroxy acid forms and their determination in Pu-Erh tea.

  Journal of chromatography. A 20060630

• Peroxisomal cholesterol biosynthesis and Smith-Lemli-Opitz syndrome.

  Biochemical and biophysical research communications 20060623

• Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease.

  Journal of immunology (Baltimore, Md. : 1950) 20060615

• Mitomycin C induces apoptosis via Fas/FasL dependent pathway and suppression of IL-18 in cervical carcinoma cells.

  Cancer letters 20060608

• Effects of the sporulation conditions on the lovastatin production by Aspergillus terreus.

  Bioprocess and biosystems engineering 20060601

• Polyamine depletion and cell cycle manipulation in combination with HSV thymidine kinase/ganciclovir cancer gene therapy.

  International journal of oncology 20060601

• Randomized comparative study of the effects of treatment with once-daily, niacin extended-release/lovastatin and with simvastatin on lipid profile and fibrinolytic parameters in Taiwan.

  The Kaohsiung journal of medical sciences 20060601

• Repression of secondary metabolite production by exogenous cAMP in Monascus.

  Bioscience, biotechnology, and biochemistry 20060601

• Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies.

  Clinical therapeutics 20060601

• Lipoprotein-associated phospholipase A2, vascular inflammation and cardiovascular risk prediction.

  Vascular health and risk management 20060601

• Plant sterols as dietary adjuvants in the reduction of cardiovascular risk: theory and evidence.

  Vascular health and risk management 20060601

• Fenofibrate: a novel formulation (Triglide) in the treatment of lipid disorders: a review.

  International journal of nanomedicine 20060601

• Statin use and breast cancer: prospective results from the Women's Health Initiative.

  Journal of the National Cancer Institute 20060517

• Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone.

  International journal of cancer 20060515

• Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo.

  Biochemical and biophysical research communications 20060512

• Statins and stroke: current clinical practice.

  Stroke 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Effect of statins on platelet PAR-1 thrombin receptor in patients with the metabolic syndrome (from the PAR-1 inhibition by statins [PARIS] study).

  The American journal of cardiology 20060501

• Moderate alcohol consumption and safety of lovastatin and warfarin among men: the post-coronary artery bypass graft trial.

  The American journal of medicine 20060501

• The quantification of monacolin K in some red yeast rice from Fujian province and the comparison of the other product.

  Chemical & pharmaceutical bulletin 20060501

• Effects of the principal nutrients on lovastatin production by Monascus pilosus.

  Bioscience, biotechnology, and biochemistry 20060501

• Is atorvastatin superior to other statins? Analysis of the clinical trials with atorvastatin having cardiovascular endpoints.

  Reviews on recent clinical trials 20060501

• Statin safety and drug interactions: clinical implications.

  The American journal of cardiology 20060417

• Statin safety: a systematic review.

  The American journal of cardiology 20060417

• Proapoptotic and antitumor activities of the HMG-CoA reductase inhibitor, lovastatin, against Dalton's lymphoma ascites tumor in mice.

  Clinica chimica acta; international journal of clinical chemistry 20060401

• Lovastatin and thalidomide have a combined effect on the rate of multiple myeloma cell apoptosis in short term cell cultures.

  European journal of clinical pharmacology 20060401

• The influence of co-treatment with carbamazepine, amiodarone and statins on warfarin metabolism and maintenance dose.

  European journal of clinical pharmacology 20060401

• Effect of rosuvastatin compared with other statins on lipid levels and National Cholesterol Education Program goal attainment for low-density lipoprotein cholesterol in a usual care setting.

  Pharmacotherapy 20060401

• Genetically determined apo B levels and peak LDL density predict angiographic response to intensive lipid-lowering therapy.

  Journal of internal medicine 20060401

• Retrospective review of sex differences in the management of dyslipidemia in coronary heart disease: an analysis of patient data from a Maryland-based health maintenance organization.

  Clinical therapeutics 20060401

• The beneficial in vitro effects of lovastatin and chelerythrine on relaxatory response to acetylcholine in the perfused mesentric bed isolated from diabetic rats.

  European journal of pharmacology 20060327

• Potential impact on cardiovascular public health of over-the-counter statin availability.

  The American journal of cardiology 20060315

• Analysis of five HMG-CoA reductase inhibitors-- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies.

  Biomedical chromatography : BMC 20060301

• Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.

  The Journal of pharmacology and experimental therapeutics 20060301

• Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport.

  Pharmaceutical research 20060301

• HMG-CoA reductase inhibitors induce apoptosis in pericytes.

  Microvascular research 20060301

• Effects of various statins on cytokine-dependent growth and IgE-dependent release of histamine in human mast cells.

  Allergy 20060301

• Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism.

  Cellular microbiology 20060301

• Evidence-based prescribing of statins: a developing world perspective.

  PLoS medicine 20060301

• Exenatide.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060301

• Low high-density lipoprotein cholesterol and cardiovascular disease: risk reduction with statin therapy.

  American heart journal 20060301

• N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• Hydroxymethylglutaryl-CoA reductase inhibitors in older persons with acute myocardial infarction: evidence for an age-statin interaction.

  Journal of the American Geriatrics Society 20060301

• Inhibitory effect of Magnolia officinalis and lovastatin on aortic oxidative stress and apoptosis in hyperlipidemic rabbits.

  Journal of cardiovascular pharmacology 20060301

• Processing of amyloid precursor protein as a biochemical link between atherosclerosis and Alzheimer's disease.

  Cardiovascular & hematological disorders drug targets 20060301

• [Lowering plasma homocysteine with vitamins B6, B12, and folic acid. Effect on lipids concentration in patients with secondary hyperlipoproteinemia type IV, with and without Lovastatina treatment].

  Archivos latinoamericanos de nutricion 20060301

• Complementary therapy to target LDL cholesterol: the role of the ezetimibe/simvastatin combination.

  Vascular health and risk management 20060301

• Evaluation of efficacy and safety of fixed dose lovastatin and niacin(ER) combination in asian Indian dyslipidemic patients: a multicentric study.

  Vascular health and risk management 20060301

• Dietary approaches that delay age-related diseases.

  Clinical interventions in aging 20060301

• Telithromycin in the treatment of acute bacterial sinusitis, acute exacerbations of chronic bronchitis, and community-acquired pneumonia.

  Therapeutics and clinical risk management 20060301

• Formal enantioselective synthesis of (+)-compactin.

  Organic letters 20060216

• Statins induce calcium-dependent mitochondrial permeability transition.

  Toxicology 20060215

• Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone.

  International journal of cancer 20060201

• The prion protein requires cholesterol for cell surface localization.

  Molecular and cellular neurosciences 20060201

• Rho/ROCK pathway as a target of tumor therapy.

  Journal of neuroscience research 20060201

• Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.

  Immunology and cell biology 20060201

• Alcohol consumption, atherosclerotic progression, and prognosis among patients with coronary artery bypass grafts.

  American heart journal 20060201

• The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201

• Lovastatin protects human endothelial cells from killing by ionizing radiation without impairing induction and repair of DNA double-strand breaks.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060201

• Lovastatin reduces apoptosis and downregulates the CD40 expression induced by TNF-alpha in cerebral vascular endothelial cells.

  Current neurovascular research 20060201

• Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro.

  Indian journal of biochemistry & biophysics 20060201

• Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells.

  Biochemical and biophysical research communications 20060120

• Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway.

  Blood 20060115

• Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.

  Cancer research 20060115

• Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies.

  Cancer chemotherapy and pharmacology 20060101

• Erythropoietin receptor signal transduction requires protein geranylgeranylation.

  The Journal of pharmacology and experimental therapeutics 20060101

• HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways.

  Cellular signalling 20060101

• Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts.

  The FEBS journal 20060101

• Statins and osteoporosis: new role for old drugs.

  The Journal of pharmacy and pharmacology 20060101

• Effects of garlic oil on postmenopausal osteoporosis using ovariectomized rats: comparison with the effects of lovastatin and 17beta-estradiol.

  Phytotherapy research : PTR 20060101

• Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro.

  Pharmacology 20060101

• Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line.

  BMC cancer 20060101

• Statin wars following coronary revascularization--evidence-based clinical practice?

  The Canadian journal of cardiology 20060101

• New treatment strategies for multiple myeloma by targeting BCL-2 and the mevalonate pathway.

  Current pharmaceutical design 20060101

• Statin-related adverse events: a meta-analysis.

  Clinical therapeutics 20060101

• Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.

  Molecular cancer 20060101

• Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo.

  BMC biochemistry 20060101

• [Correction of thrombocyte-vascular hemostasis in metabolic syndrome].

  Klinicheskaia meditsina 20060101

• Fluvastatin does not elevate periosteal osteogenesis induce by Moloney sarcoma virus (MSV) in mice.

  Pharmacological reports : PR 20060101

• Guinea pigs: a suitable animal model to study lipoprotein metabolism, atherosclerosis and inflammation.

  Nutrition & metabolism 20060101

• Action of Lovastatin (Mevinolin) on an in vitro model of angiogenesis and its co-culture with malignant melanoma cell lines.

  Cancer cell international 20060101

• Lovastatin production by Pleurotus ostreatus: effects of the C:N ratio.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

• Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia.

  Journal of neuroinflammation 20060101

• Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome.

  Orphanet journal of rare diseases 20060101

• A randomized trial to assess the impact of opinion leader endorsed evidence summaries on the use of secondary prevention strategies in patients with coronary artery disease: the ESP-CAD trial protocol [NCT00175240].

  Implementation science : IS 20060101

• Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20060101

• Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts.

  Arthritis research & therapy 20060101

• Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice.

  Neuromolecular medicine 20060101

• Cost-effectiveness analysis of cholesterol-lowering therapies in Spain.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101

• Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice.

  Journal of AOAC International 20060101

• Comparison between mevinolin and PTH action on MG63 osteoblast-like cells.

  Biomedical sciences instrumentation 20060101

• Adherence and persistence with single-dosage form extended-release niacin/lovastatin compared with statins alone or in combination with extended-release niacin.

  The Annals of pharmacotherapy 20060101

• Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.

  Arthritis research & therapy 20060101

• Safety issues with statin therapy.

  Journal of the American Pharmacists Association : JAPhA 20060101

• Coronary heart disease policy models: a systematic review.

  BMC public health 20060101

• A long-term study of dyslipidemia and dyslipoproteinemia in stable post-renal transplant patients.

  Renal failure 20060101

• Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease.

  Journal of biomedicine & biotechnology 20060101

• Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1.

  Retrovirology 20060101

• Statins, bugs and prophylaxis: intriguing possibilities.

  Critical care (London, England) 20060101

• Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials.

  Chinese medicine 20060101

• Determination by chromatographic methods of selected medicines reducing the level of cholesterol.

  Acta poloniae pharmaceutica 20060101

• Effect of Monascus purpureus-fermented rice on lipidemia and fatty liver in quail.

  Research communications in molecular pathology and pharmacology 20060101

• [A short-term effect of lovastatin on lipoprotein metabolism in patients with cerebrovascular lesions concomitant with diabetes mellitus II type].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• Liver X receptor alpha interferes with SREBP1c-mediated Abcd2 expression. Novel cross-talk in gene regulation.

  The Journal of biological chemistry 20051216

• Implications from the Air Force/Texas Coronary Atherosclerosis Prevention Study for the Adult Treatment Panel III guidelines.

  The American journal of cardiology 20051215

• Statins prevent beta-amyloid inhibition of sympathetic alpha7-nAChR-mediated nitrergic neurogenic dilation in porcine basilar arteries.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20051201

• Lovastatin stimulates p75 TNF receptor (TNFR2) expression in primary human endothelial cells.

  International journal of molecular medicine 20051201

• Plasma clearance of lovastatin versus chinese red yeast rice in healthy volunteers.

  Journal of alternative and complementary medicine (New York, N.Y.) 20051201

• Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results.

  Arquivos de neuro-psiquiatria 20051201

• Extracts of Monascusus purpureus beyond statins--profile of efficacy and safety of the use of extracts of Monascus purpureus.

  Chinese journal of integrative medicine 20051201

• [Fluvastatin-induced dermatomyositis].

  Annales de dermatologie et de venereologie 20051201

• Replication of Coxiella burnetii is inhibited in CHO K-1 cells treated with inhibitors of cholesterol metabolism.

  Annals of the New York Academy of Sciences 20051201

• Optimal lipid modification: the rationale for combination therapy.

  Vascular health and risk management 20051201

• Efficacy and safety of atorvastatin in South Asian patients with dyslipidemia: an open label noncomparative pilot study.

  Vascular health and risk management 20051201

• Are statins being underdosed in clinical practice? Data from TACTICS-TIMI 18.

  Critical pathways in cardiology 20051201

• Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality.

  Therapeutics and clinical risk management 20051201

• INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.

  The EMBO journal 20051116

• Lovastatin stimulates up-regulation of alpha7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the alpha-form of secreted amyloid precursor protein.

  Journal of neuroscience research 20051115

• The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.

  Current biology : CB 20051108

• The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells.

  The Journal of surgical research 20051101

• Pregnancy outcomes after maternal exposure to simvastatin and lovastatin.

  Birth defects research. Part A, Clinical and molecular teratology 20051101

• Optimal goals for statin use in patients with coronary artery disease.

  Current opinion in cardiology 20051101

• PAF-receptor antagonists, lovastatin, and the PTK inhibitor genistein inhibit H2O2 secretion by macrophages cultured on oxidized-LDL matrices.

  Journal of leukocyte biology 20051101

• Experience with statin use in patients with chronic hepatitis C infection.

  The American journal of cardiology 20051101

• X-Hitting: an algorithm for novelty detection and dereplication by UV spectra of complex mixtures of natural products.

  Analytical chemistry 20051101

• Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.

  Cellular and molecular life sciences : CMLS 20051101

• The effect of switching on compliance and persistence: the case of statin treatment.

  The American journal of managed care 20051101

• Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine.

  International journal of clinical pharmacology and therapeutics 20051101

• Safety of statins: effects on muscle and the liver.

  Cleveland Clinic journal of medicine 20051101

• The benefits of statin therapy--what questions remain?

  Clinical cardiology 20051101

• Statins and fibrates for preventing melanoma.

  The Cochrane database of systematic reviews 20051019

• Calmodulin binding to the small GTPase Ral requires isoprenylated Ral.

  Biochemical and biophysical research communications 20051014

• Evaluation of the anti-HIV activity of statins.

  AIDS (London, England) 20051014

• Hypolipidaemic and antioxidant effect of Enicostemma littorale Blume aqueous extract in cholesterol fed rats.

  Journal of ethnopharmacology 20051003

• Cholesterol biosynthesis and the pro-apoptotic effects of the p75 nerve growth factor receptor in PC12 pheochromocytoma cells.

  Brain research. Molecular brain research 20051003

• In vitro effect of statins on cytokine production and mitogen response of human peripheral blood mononuclear cells.

  Clinical immunology (Orlando, Fla.) 20051001

• Persistence and determinants of statin therapy among middle-aged patients free of cardiovascular disease.

  European journal of clinical pharmacology 20051001

• Differential association between statin exposure and elevated levels of creatine kinase.

  The Annals of pharmacotherapy 20051001

• Clinical and economic outcomes of conversion of simvastatin to lovastatin in a group-model health maintenance organization.

  Journal of managed care pharmacy : JMCP 20051001

• Tobacco BY-2 cells expressing fission yeast cdc25 bypass a G2/M block on the cell cycle.

  The Plant journal : for cell and molecular biology 20051001

• The association between RhoB and caspase-2: changes with lovastatin-induced apoptosis.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20051001

• Statins modulate the levels of osteoprotegerin/receptor activator of NFkappaB ligand mRNA in mouse bone-cell cultures.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20051001

• Grape fruit juice-drug interactions.

  Pakistan journal of pharmaceutical sciences 20051001

• [Hypolipidemic treatment under special conditions: posttransplant and/or immunosuppressive therapy].

  Arquivos brasileiros de cardiologia 20051001

• Study on red fermented rice with high concentration of monacolin K and low concentration of citrinin.

  International journal of food microbiology 20050915

• Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.

  Journal of molecular biology 20050909

• Review of primary and secondary prevention trials with lovastatin, pravastatin, and simvastatin.

  The American journal of cardiology 20050905

• Lovastatin inhibits the growth and survival pathway of phosphoinositide 3-kinase/protein kinase B in immortalized rat brain neuroblasts.

  Journal of neurochemistry 20050901

• HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050901

• The pharmacological potential of mushrooms.

  Evidence-based complementary and alternative medicine : eCAM 20050901

• Efficacy and safety of lovastatin therapy in adolescent girls with heterozygous familial hypercholesterolemia.

  Pediatrics 20050901

• Lovastatin reduces nuclear factor kappaB activation induced by C-reactive protein in human vascular endothelial cells.

  Biological & pharmaceutical bulletin 20050901

• Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells.

  British journal of haematology 20050901

• Successful conversion of patients with hypercholesterolemia from a brand name to a generic cholesterol-lowering drug.

  The American journal of managed care 20050901

• Lovastatin suppresses invasiveness of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling.

  Endocrine-related cancer 20050901

• Regulation of connexin expression after balloon injury: possible mechanisms for antiproliferative effect of statins.

  American journal of hypertension 20050901

• Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells.

  British journal of cancer 20050808

• Leukocyte function-associated antigen 1-mediated adhesion stability is dynamically regulated through affinity and valency during bond formation with intercellular adhesion molecule-1.

  The Journal of biological chemistry 20050805

• Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation.

  Molecular and cellular neurosciences 20050801

• Genomic effect of vitamin 'C' and statins within human mononuclear cells involved in atherogenic process.

  European journal of clinical nutrition 20050801

• Lipoprotein-associated phospholipase A2 as a target of therapy.

  Current opinion in lipidology 20050801

• Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8.

  Basic & clinical pharmacology & toxicology 20050801

• The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, lovastatin (statin) ameliorates CCK-induced acute pancreatitis in rats.

  Biological & pharmaceutical bulletin 20050801

• Evolutionary relationships among Aspergillus terreus isolates and their relatives.

  Antonie van Leeuwenhoek 20050801

• Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity.

  European journal of clinical investigation 20050801

• Polar body formation in Spisula oocytes: function of the peripheral aster.

  The Biological bulletin 20050801

• [Effect of Laminaria japonica polysaccharides on lowing serum lipid and anti-atherosclerosis in hyperlipemia quails].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050801

• Natural insights for chemical biologists.

  Nature chemical biology 20050801

• Risks of a nonprescription lovastatin.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050715

• Association between short-term effectiveness of statins and long-term adherence to lipid-lowering therapy.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050715

• Induction of macrophage elastase (MMP-12) gene expression by statins.

  Journal of cellular physiology 20050701

• Direct comparison of dietary portfolio vs statin on C-reactive protein.

  European journal of clinical nutrition 20050701

• Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction.

  Journal of neurochemistry 20050701

• Low high-density lipoprotein cholesterol disorders and cardiovascular risk: contribution of associated low-density lipoprotein subclass abnormalities.

  Current opinion in cardiology 20050701

• Cholesterol levels and statin use in patients with coronary heart disease treated in primary care settings.

  Preventing chronic disease 20050701

• Effects of cholesterol-lowering statins on the aqueous humor outflow pathway.

  Investigative ophthalmology & visual science 20050701

• In vivo and in vitro effects of statins on lymphocytes in patients with Hashimoto's thyroiditis.

  European journal of endocrinology 20050701

• JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050701

• Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly.

  The New England journal of medicine 20050630

• Degradation of HMG-CoA reductase in rat liver is cholesterol and ubiquitin independent.

  FEBS letters 20050606

• Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities.

  Journal of lipid research 20050601

• Statin drugs and congenital anomalies.

  American journal of medical genetics. Part A 20050601

• Relation of progression of coronary artery atherosclerosis to risk of cardiovascular events (from the Monitored Atherosclerosis Regression Study).

  The American journal of cardiology 20050601

• A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin.

  Atherosclerosis 20050601

• The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells.

  Journal of Korean medical science 20050601

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20050601

• 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway.

  Journal of chemical ecology 20050601

• A new paradigm of cardiovascular risk factor modification.

  Vascular health and risk management 20050601

• PKCalpha is involved in phorbol ester TPA-mediated stabilization of p14ARF.

  Biochemical and biophysical research communications 20050520

• Remote asymmetric induction in an intramolecular ionic Diels-Alder reaction: application to the total synthesis of (+)-dihydrocompactin.

  Journal of the American Chemical Society 20050511

• HMG CoA reductase inhibitors (statins) to treat Epstein-Barr virus-driven lymphoma.

  British journal of cancer 20050509

• Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells.

  Carcinogenesis 20050501

• Hepatic uptake of the novel antifungal agent caspofungin.

  Drug metabolism and disposition: the biological fate of chemicals 20050501

• The sterol response element binding protein regulates cyclooxygenase-2 gene expression in endothelial cells.

  Journal of lipid research 20050501

• Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta.

  Arteriosclerosis, thrombosis, and vascular biology 20050501

• Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo.

  Leukemia research 20050501

• Effects of atorvastatin versus other statins on fasting and postprandial C-reactive protein and lipoprotein-associated phospholipase A2 in patients with coronary heart disease versus control subjects.

  The American journal of cardiology 20050501

• Ascorbate depletion: a critical step in nickel carcinogenesis?

  Environmental health perspectives 20050501

• A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial.

  Mayo Clinic proceedings 20050501

• National trends in statin use by coronary heart disease risk category.

  PLoS medicine 20050501

• [Hypothyroidism and lovastatin-induced myositis].

  Anales de medicina interna (Madrid, Spain : 1984) 20050501

• Statins reduce connexin40 and connexin43 expression in atherosclerotic aorta of rabbits.

  International journal of cardiology 20050428

• Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: an evaluation of class effect.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050426

• Frequency of myopathy in patients receiving lovastatin.

  The American journal of cardiology 20050415

• Statins potentiate the IFN-gamma-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells.

  Biochimica et biophysica acta 20050415

• Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

  Drug metabolism and disposition: the biological fate of chemicals 20050401

• Projected coronary heart disease risk benefit with ezetimibe.

  Atherosclerosis 20050401

• Measurement of saturable and non-saturable components of anandamide uptake into P19 embryonic carcinoma cells in the presence of fatty acid-free bovine serum albumin.

  Chemistry and physics of lipids 20050401

• Post-translational processing of beta-secretase in Alzheimer's disease.

  Proteomics 20050401

• The effect of lovastatin and thioridazine on the degradation of cocaine in human serum in vitro.

  Therapeutic drug monitoring 20050401

• Heart failure and statins--why do we need a clinical trial?

  Zeitschrift fur Kardiologie 20050401

• Disruption of lipid rafts causes apoptotic cell death in HaCaT keratinocytes.

  Experimental dermatology 20050401

• [Effects of fosmidomycin and lovastatin treatment on taxol biosynthesis in suspension culture cells of Taxus chinensis].

  Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology 20050401

• Lovastatin-induced apoptosis in human melanoma cell lines.

  Melanoma research 20050401

• Targeted therapy in multiple myeloma.

  Cancer control : journal of the Moffitt Cancer Center 20050401

• A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense.

  American journal of respiratory and critical care medicine 20050315

• The regulation of beta-secretase by cholesterol and statins in Alzheimer's disease.

  Journal of the neurological sciences 20050315

• Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050315

• Pellet morphology, culture rheology and lovastatin production in cultures of Aspergillus terreus.

  Journal of biotechnology 20050302

• Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro.

  Biology of reproduction 20050301

• A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix.

  European journal of cancer (Oxford, England : 1990) 20050301

• FDA advisers vote against nonprescription lovastatin.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050301

• Is atorvastatin more appropriate to use in combination with niacin than simvastatin in patients with the metabolic syndrome?

  American heart journal 20050301

• Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells.

  Journal of experimental & clinical cancer research : CR 20050301

• A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.

  The AAPS journal 20050301

• Ongoing clinical trials of the pleiotropic effects of statins.

  Vascular health and risk management 20050301

• Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.

  Therapeutics and clinical risk management 20050301

• Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction.

  Journal of immunology (Baltimore, Md. : 1950) 20050215

• [The 'healthy' patient with hypercholesterolemia].

  Medizinische Klinik (Munich, Germany : 1983) 20050215

• Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells.

  FEBS letters 20050214

• Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex.

  The Journal of pharmacology and experimental therapeutics 20050201

• Statins as coronary vasodilators in isolated bovine coronary arteries--involvement of PGI2 and NO.

  Prostaglandins, leukotrienes, and essential fatty acids 20050201

• Differential effects of RhoA signaling on anticancer agent-induced cell death.

  Oncology reports 20050201

• Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update.

  Fundamental & clinical pharmacology 20050201

• Existence of a clinically relevant interaction between clopidogrel and HMG-CoA reductase inhibitors? Re-evaluating the evidence.

  Basic & clinical pharmacology & toxicology 20050201

• Gender-specific effects of estrogen receptor alpha gene haplotype on high-density lipoprotein cholesterol response to atorvastatin: interaction with apolipoprotein AI gene polymorphism.

  Atherosclerosis 20050201

• Lovastatin compromises C-reactive protein induced endothelial dysfunction including altered expression of cell adhesion molecules and increased monocyte recruitment.

  Atherosclerosis 20050201

• Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes.

  The American journal of the medical sciences 20050201

• Statins and osteoporosis: a clinical review.

  Pharmacotherapy 20050201

• Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells.

  Analytical biochemistry 20050101

• Factors regulating macrophage endocytosis of nanoparticles: implications for targeted magnetic resonance plaque imaging.

  Atherosclerosis 20050101

• Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha).

  Biochemical pharmacology 20050101

• Examination of 209 drugs for inhibition of cytochrome P450 2C8.

  Journal of clinical pharmacology 20050101

• Rosuvastatin reduces plasma lipids by inhibiting VLDL production and enhancing hepatobiliary lipid excretion in ApoE*3-leiden mice.

  Journal of cardiovascular pharmacology 20050101

• Effect of tadalafil on cytochrome P450 3A4-mediated clearance: studies in vitro and in vivo.

  Clinical pharmacology and therapeutics 20050101

• Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK.

  PLoS medicine 20050101

• Endogenous cytokinin oscillations control cell cycle progression of tobacco BY-2 cells.

  Plant biology (Stuttgart, Germany) 20050101

• Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction.

  International journal of cardiology 20050101

• Changes in lipids over twelve months after initiating protease inhibitor therapy among persons treated for HIV/AIDS.

  Lipids in health and disease 20050101

• Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q(10) levels in ICR mice.

  The British journal of nutrition 20050101

• Parallel capillary electrophoresis for the quantitative screening of fermentation broths containing natural products.

  Metabolic engineering 20050101

• Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?

  Arthritis research & therapy 20050101

• Human macrophages limit oxidation products in low density lipoprotein.

  Lipids in health and disease 20050101

• Cost effectiveness of treating low HDL-cholesterol in the primary prevention of coronary heart disease.

  PharmacoEconomics 20050101

• [Effects of withdrawal of statins on nitric oxide production in vascular endothelial cells].

  Zhonghua nei ke za zhi 20050101

• The effects of cholesterol lowering with simvastatin on cause-specific mortality and on cancer incidence in 20,536 high-risk people: a randomised placebo-controlled trial [ISRCTN48489393].

  BMC medicine 20050101

• Renewed interest in lovastatin following launch of Lovachol.

  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20050101

• Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK.

  Molecular and cellular biochemistry 20050101

• The 'Statinth' wonder of the world: a panacea for all illnesses or a bubble about to burst.

  Journal of negative results in biomedicine 20050101

• Effect of cholesterol lowering and cardiovascular risk factors on the progression of aortoiliac arteriosclerosis: a quantitative cineangiography study.

  Angiology 20050101

• [Protective effects of Lovastatin on early diabetic renal tissue and the possible mechanism].

  Wei sheng yan jiu = Journal of hygiene research 20050101

• Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.

  Clinical pharmacokinetics 20050101

• The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis.

  Arthritis research & therapy 20050101

• Effect of rosuvastatin on outcomes in chronic haemodialysis patients - design and rationale of the AURORA study.

  Current controlled trials in cardiovascular medicine 20050101

• Comparison of rosuvastatin and atorvastatin for lipid lowering in patients with type 2 diabetes mellitus: results from the URANUS study.

  Cardiovascular diabetology 20050101

• [Prevalence of nonmevalonate and mevalonate pathways for isoprenoid biosynthesis among bacteria of different systematic groups].

  Mikrobiologiia 20050101

• Statins research unfinished saga: desirability versus feasibility.

  Cardiovascular diabetology 20050101

• An association study of 43 SNPs in 16 candidate genes with atorvastatin response.

  The pharmacogenomics journal 20050101

• [Isoprenoid pigments in representatives of the family Microbacteriaceae].

  Mikrobiologiia 20050101

• Relationship between lipophilicity of BCS class III and IV drugs and the functional activity of peroral absorption enhancers.

  Farmaco (Societa chimica italiana : 1989) 20050101

• Enzymatic examination of potential interaction between statins or fibrates and consumed Tricholoma equestre.

  Przeglad lekarski 20050101

• Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers.

  Farmaco (Societa chimica italiana : 1989) 20050101

• Time as a variable with niacin extended-release/lovastatin vs. atorvastatin and simvastatin.

  Preventive cardiology 20050101

• Considerations in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation.

  Preventive cardiology 20050101

• Treatment of dyslipidemia with lovastatin and ezetimibe in an adolescent with cholesterol ester storage disease.

  Lipids in health and disease 20050101

• [Impact of dietotherapy with enterosorbent of marine origin on the indices of mineral and lipid metabolism for patients suffering from kidney diseases].

  Voprosy pitaniia 20050101

• Cost-effectiveness of rosuvastatin compared with other statins from a managed care perspective.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20050101

• Pharmacist intervention in safe and effective conversion of brand to generic drugs.

  Journal of managed care pharmacy : JMCP 20050101

• Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.

  Journal of neuroinflammation 20050101

• [Interactions in solution between cyclodextrins and statins].

  Acta pharmaceutica Hungarica 20050101

• Altered mitochondrial function and cholesterol synthesis influences protein synthesis in extended HepG2 spheroid cultures.

  Archives of biochemistry and biophysics 20041215

• The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells.

  Free radical biology & medicine 20041215

• Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins.

  American journal of medical genetics. Part A 20041215

• Statin-associated exacerbation of myasthenia gravis.

  Neurology 20041214

• HMG-CoA reductase inhibitors induce COX-2 gene expression in murine macrophages: role of MAPK cascades and promoter elements for CREB and C/EBPbeta.

  Experimental cell research 20041210

• Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression.

  Journal of lipid research 20041201

• Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux.

  Arteriosclerosis, thrombosis, and vascular biology 20041201

• Niacin therapy in atherosclerosis.

  Current opinion in lipidology 20041201

• Lovastatin potentiates antitumor effects of saquinavir against human lymphoma cells.

  Oncology reports 20041201

• Hypolipidemic drugs can change the composition of rat brain lipids.

  The Tohoku journal of experimental medicine 20041201

• [Effects of lovastatin on renal function and expression of phosphorylating-p38 mitogen-activated protein kinase in experimental diabetic nephropathy in rats].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20041201

• Atazanavir for the treatment of human immunodeficiency virus infection.

  Pharmacotherapy 20041201

• Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults.

  The American journal of medicine 20041201

• Consistency in efficacy and safety of ezetimibe coadministered with statins for treatment of hypercholesterolemia in women and men.

  Journal of women's health (2002) 20041201

• [Therapeutic compliance in the prevention of primary cardiovascular diseases with lovastatine. PRELOVAS study].

  Medicina clinica 20041120

• Modified mutation method for screening low citrinin-producing strains of Monascus purpureus on rice culture.

  Journal of agricultural and food chemistry 20041117

• Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells.

  Journal of cellular biochemistry 20041115

• A Consumer Use Study of Over-The-Counter lovastatin (CUSTOM).

  The American journal of cardiology 20041115

• Over-the-counter statin drug.

  The American journal of cardiology 20041115

• Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia.

  The Journal of biological chemistry 20041112

• Recurrent acute pancreatitis possibly induced by atorvastatin and rosuvastatin. Is statin induced pancreatitis a class effect?

  JOP : Journal of the pancreas 20041110

• Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells.

  Circulation 20041109

• Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo.

  The Journal of biological chemistry 20041105

• Consumer behavior in the setting of over-the-counter statin availability: lessons from the consumer use study of OTC Mevacor.

  The American journal of cardiology 20041104

• Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols.

  Journal of lipid research 20041101

• Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol.

  Arteriosclerosis, thrombosis, and vascular biology 20041101

• Bis[3-(4'-substituted phenyl)prop-2-ene]disulfides as a new class of antihyperlipidemic compounds.

  Bioorganic & medicinal chemistry letters 20041101

• Statin compounds reduce human immunodeficiency virus type 1 replication by preventing the interaction between virion-associated host intercellular adhesion molecule 1 and its natural cell surface ligand LFA-1.

  Journal of virology 20041101

• Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin.

  Cardiovascular research 20041101

• OTC status for low-dose lovastatin would have widespread implications.

  Managed care (Langhorne, Pa.) 20041101

• Lovastatin modulation of microglial activation via suppression of functional CD40 expression.

  Journal of neuroscience research 20041015

• Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism.

  Carcinogenesis 20041001

• Management of hypertriglyceridemia in patients receiving interferon for malignant melanoma.

  The Annals of pharmacotherapy 20041001

• Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.

  Brain research 20041001

• Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits.

  Clinical nutrition (Edinburgh, Scotland) 20041001

• C-reactive protein-induced expression of CD40-CD40L and the effect of lovastatin and fenofibrate on it in human vascular endothelial cells.

  Biological & pharmaceutical bulletin 20041001

• Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis.

  Fertility and sterility 20041001

• Nevirapine and efavirenz elicit different changes in lipid profiles in antiretroviral-therapy-naive patients infected with HIV-1.

  PLoS medicine 20041001

• Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. 1976.

  Atherosclerosis. Supplements 20041001

• Therapeutic effects of ml-236B in primary hypercholesterolemia. 1980.

  Atherosclerosis. Supplements 20041001

• Effects of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase on serum lipoproteins and ubiquinone-10 levels in patients with familial hypercholesterolemia. 1981.

  Atherosclerosis. Supplements 20041001

• Lowering plasma cholesterol by raising ldl receptors. 1981.

  Atherosclerosis. Supplements 20041001

• Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983.

  Atherosclerosis. Supplements 20041001

• Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain.

  Neurochemical research 20041001

• [Study on space flight-mutants of Monascus purpureus using Random Amplified Polymorphic DNA].

  Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering 20041001

• Dietary palmitic acid influences LDL-mediated lymphocyte proliferation differently to other mono- and polyunsaturated fatty acids in rats.

  Diabetes, nutrition & metabolism 20041001

• The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase.

  Blood 20040915

• Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells.

  Blood 20040915

• Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis.

  Cancer research 20040915

• Development of methodologies based on HPLC and Raman spectroscopy for monitoring the stability of lovastatin in solid state in the presence of gallic acid.

  Journal of pharmaceutical and biomedical analysis 20040903

• Identification and chemical profiling of monacolins in red yeast rice using high-performance liquid chromatography with photodiode array detector and mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20040903

• Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38.

  The Journal of investigative dermatology 20040901

• Development of an acetylene black-dihexadecyl hydrogen phosphate composite-modified glassy-carbon electrode, and its application in the determination of lovastatin in dosage drug forms.

  Analytical and bioanalytical chemistry 20040901

• Statins inhibit reoxygenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3beta and transcription factor beta-catenin.

  Journal of molecular and cellular cardiology 20040901

• [Vastatins in atherosclerosis prevention. Current data].

  Arquivos brasileiros de cardiologia 20040901

• Pharmacokinetic interaction between ezetimibe and lovastatin in healthy volunteers.

  Current medical research and opinion 20040901

• Oral administration of pravastatin reduces egg cholesterol but not plasma cholesterol in laying hens.

  Poultry science 20040901

• New decalin derivatives, eujavanoic acids A and B, from Eupenicillium javanicum.

  Journal of natural products 20040901

• Rosuvastatin in the management of hyperlipidemia.

  Clinical therapeutics 20040901

• Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.

  Circulation research 20040820

• Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins.

  Circulation 20040817

• Statins inhibit HIV-1 infection by down-regulating Rho activity.

  The Journal of experimental medicine 20040816

• Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid.

  Carcinogenesis 20040801

• Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin.

  Blood 20040801

• Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors.

  American journal of physiology. Heart and circulatory physiology 20040801

• Chronic mevastatin modulates receptor-dependent vascular contraction in eNOS-deficient mice.

  American journal of physiology. Regulatory, integrative and comparative physiology 20040801

• Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.

  Arteriosclerosis, thrombosis, and vascular biology 20040801

• Cholesterol (and cardiovascular risk) in adolescence.

  Current opinion in pediatrics 20040801

• Safety and compliance with once-daily niacin extended-release/lovastatin as initial therapy in the Impact of Medical Subspecialty on Patient Compliance to Treatment (IMPACT) study.

  The American journal of cardiology 20040801

• Lipid-lowering response to statins is affected by CYP3A5 polymorphism.

  Pharmacogenetics 20040801

• Focal adhesion kinase mediates endothelin-induced cyclin D3 expression in rat cultured astrocytes.

  Journal of neurochemistry 20040801

• [Effects of lovastatin on cell cycle distribution in MCF-7 cells transfected with BRCA1].

  Ai zheng = Aizheng = Chinese journal of cancer 20040801

• The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement.

  Histochemistry and cell biology 20040801

• The multifunctional role of fibroblasts during wound healing in Hirudo medicinalis (Annelida, Hirudinea).

  Biology of the cell 20040801

• Efficacy and safety of ezetimibe coadministered with statins: randomised, placebo-controlled, blinded experience in 2382 patients with primary hypercholesterolemia.

  International journal of clinical practice 20040801

• Lipid rafts mediate the synaptic localization of alpha-synuclein.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040728

• Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis.

  Biochemical and biophysical research communications 20040716

• Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats.

  Bioorganic & medicinal chemistry 20040701

• Regulation of gene expression associated with acute experimental autoimmune encephalomyelitis by Lovastatin.

  Journal of neuroscience research 20040701

• Differential effects of simvastatin on mesangial cells.

  Kidney international 20040701

• Genetically modified mice and their use in developing therapeutic strategies for prostate cancer.

  The Journal of urology 20040701

• Extended-release niacin/lovastatin: the first combination product for dyslipidemia.

  Expert review of cardiovascular therapy 20040701

• Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention.

  Experimental biology and medicine (Maywood, N.J.) 20040701

• Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors.

  Biochemical pharmacology 20040615

• Compactin-a review.

  Applied microbiology and biotechnology 20040601

• Maintenance of G1 checkpoint controls in telomerase-immortalized endothelial cells.

  Cell cycle (Georgetown, Tex.) 20040601

• Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS.

  Analytical biochemistry 20040601

• Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.

  Protein science : a publication of the Protein Society 20040601

• Extended-release niacin for modifying the lipoprotein profile.

  Expert opinion on pharmacotherapy 20040601

• Multisite inhibition by phenylacetate of PC-3 cell growth.

  Anti-cancer drugs 20040601

• Overdependence on the host-an Achilles' heel of HCV?

  Hepatology (Baltimore, Md.) 20040601

• Statins: novel additions to the dermatologic arsenal?

  Experimental dermatology 20040601

• Effects of ezetimibe on the pharmacodynamics and pharmacokinetics of lovastatin.

  Current medical research and opinion 20040601

• [In vitro effects of mevastatin on the proliferation and apoptosis in human multiple myeloma cell line U266].

  Zhongguo shi yan xue ye xue za zhi 20040601

• Metaanalysis of statins and survival in de novo cardiac transplantation.

  Transplantation proceedings 20040601

• The role of maternal toxicity in lovastatin-induced developmental toxicity.

  Birth defects research. Part B, Developmental and reproductive toxicology 20040601

• Molecular basis of ML-236B production in the high-producing mutant No. 41520 of Penicillium citrinum.

  The Journal of general and applied microbiology 20040601

• Efficacy of extended-release niacin with lovastatin for hypercholesterolemia: assessing all reasonable doses with innovative surface graph analysis.

  Archives of internal medicine 20040524

• Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain.

  Bioorganic & medicinal chemistry letters 20040517

• Hydrophilic 7 beta-hydroxy bile acids, lovastatin, and cholestyramine are ineffective in the treatment of cerebrotendinous xanthomatosis.

  Metabolism: clinical and experimental 20040501

• Class-specific pro-apoptotic effect of statins on human vascular endothelial cells.

  Zeitschrift fur Kardiologie 20040501

• Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model.

  Radiation research 20040501

• Statins and liver toxicity: a meta-analysis.

  Pharmacotherapy 20040501

• Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice.

  British journal of cancer 20040419

• Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.

  Biochemical and biophysical research communications 20040409

• Cyclin E deregulation alters the biologic properties of ovarian cancer cells.

  Oncogene 20040408

• Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems.

  British journal of clinical pharmacology 20040401

• Psychological and cognitive function: predictors of adherence with cholesterol lowering treatment.

  Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 20040401

• Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells.

  Journal of neurochemistry 20040401

• Depletion of cellular cholesterol and lipid rafts increases shedding of CD30.

  Journal of immunology (Baltimore, Md. : 1950) 20040401

• LaeA, a regulator of secondary metabolism in Aspergillus spp.

  Eukaryotic cell 20040401

• Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells.

  Biochimica et biophysica acta 20040322

• Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling.

  Biochemical and biophysical research communications 20040312

• Rational elimination of Aspergillus terreus sulochrin production.

  Journal of biotechnology 20040304

• Effects of brassinazole, an inhibitor of brassinosteroid biosynthesis, on light- and dark-grown Chlorella vulgaris.

  Planta 20040301

• Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study.

  Brain : a journal of neurology 20040301

• Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism.

  Arteriosclerosis, thrombosis, and vascular biology 20040301

• Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels.

  The Plant journal : for cell and molecular biology 20040301

• De novo biosynthesis and radiolabeling of mammalian digitalis-like factors.

  Clinical chemistry 20040301

• Eggplant (Solanum melongena) extract does not alter serum lipid levels.

  Arquivos brasileiros de cardiologia 20040301

• Association of dyslipidemia and effects of statins on nonmacrovascular diseases.

  Clinical therapeutics 20040301

• Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition.

  Life sciences 20040213

• Statin use and cancer risk in the General Practice Research Database.

  British journal of cancer 20040209

• Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth.

  The Journal of biological chemistry 20040206

• Hormonal changes with cholesterol reduction: a double-blind pilot study.

  Journal of clinical pharmacy and therapeutics 20040201

• Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040201

• Oral anticoagulant drug interactions with statins: case report of fluvastatin and review of the literature.

  Pharmacotherapy 20040201

• Atorvastatin: gold standard for prophylaxis of myocardial ischemia and stroke - comparison of the clinical benefit of statins on the basis of randomized controlled endpoint studies.

  European journal of medical research 20040126

• Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication.

  Biochemical and biophysical research communications 20040123

• Statins potentiate caspase-3 activity in immortalized murine neurons.

  Neuroscience letters 20040123

• Influence of lipid lowering fibrates on P-glycoprotein activity in vitro.

  Biochemical pharmacology 20040115

• Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression.

  Biochemical pharmacology 20040115

• Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy.

  Journal of immunology (Baltimore, Md. : 1950) 20040115

• Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase.

  Neuroscience letters 20040109

• Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040101

• Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose.

  Plant physiology 20040101

• Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development.

  The Plant cell 20040101

• Differential effects of lipid-lowering agents on human cholinesterases.

  Clinical biochemistry 20040101

• Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer.

  Breast cancer research : BCR 20040101

• Statin therapy in patients with coronary artery disease improves the impaired endothelial progenitor cell differentiation into cardiomyogenic cells.

  Basic research in cardiology 20040101

• Comparisons of effects of statins (atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin) on fasting and postprandial lipoproteins in patients with coronary heart disease versus control subjects.

  The American journal of cardiology 20040101

• Allocation of resources between smoking cessation methods and lovastatin treatment of hypercholesterolaemia: based on cost effectiveness and the social welfare function.

  PharmacoEconomics 20040101

• Lovastatin inhibits its own synthesis in Aspergillus terreus.

  Journal of industrial microbiology & biotechnology 20040101

• Efficacy of once-daily extended-release lovastatin as compared to immediate-release lovastatin in patients with hypercholesterolemia.

  Current medical research and opinion 20040101

• Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.

  Lipids in health and disease 20040101

• [X-linked adrenoleukodystrophy (ALD)].

  Nihon rinsho. Japanese journal of clinical medicine 20040101

• Gene transfer into human hepatoma cells by receptor-associated protein/polylysine conjugates.

  Bioconjugate chemistry 20040101

• Down-regulating effect of nicotine on connexin43 gap junctions in human umbilical vein endothelial cells is attenuated by statins.

  European journal of cell biology 20040101

• Rising statin use and effect on ischemic stroke outcome.

  BMC medicine 20040101

• C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases.

  Medical hypotheses 20040101

• Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation.

  BMC cell biology 20040101

• Effect of Lovastatin on lipid peroxidation and total antioxidant concentrations in hemodialysis patients.

  Lipids in health and disease 20040101

• The influence of statins on the free intracellular calcium concentration in human umbilical vein endothelial cells.

  BMC cardiovascular disorders 20040101

• Assessing compliance of cardiologists with the national cholesterol education program (NCEP) III guidelines in an ambulatory care setting.

  Lipids in health and disease 20040101

• Lichenoid drug eruption with HMG-CoA reductase inhibitors (fluvastatin and lovastatin).

  Acta dermato-venereologica 20040101

• DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells.

  BMC cancer 20040101

• Statins rise cytoplasmic calcium level [Ca2+]i in cultured endothelial cells.

  Polish journal of pharmacology 20040101

• [Idiopathic membranous nephropathy associated with anti-calcineurin toxicity. Prognosis and other immunosuppressive treatments].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20040101

• Effect of Nandrolone Decanoate on serum lipoprotein (a) and its isoforms in hemodialysis patients.

  Lipids in health and disease 20040101

• Cost-effectiveness analysis of simvastatin and lovastatin/extended- release niacin to achieve LDL and HDL goal using NHANES data.

  Journal of managed care pharmacy : JMCP 20040101

• Combinatorial chemoprevention: efficacy of lovostatin and exisulind on the formation and progression of aberrant crypt foci.

  Anticancer research 20040101

• Mevastatin-induced apoptosis and growth suppression in U266 myeloma cells.

  Anticancer research 20040101

• Role of isoprenoids in cytoskeleton integrity and albumin endocytosis by opossum kidney cells.

  Nephron. Experimental nephrology 20040101

• Pharmacokinetic study on lovastatin sustained-release tablet and sustained-release capsule in Beagal dogs.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101

• Low-molecular-weight cyclin E: the missing link between biology and clinical outcome.

  Breast cancer research : BCR 20040101

• Metabolic cholesterol depletion hinders cell-surface trafficking of the nicotinic acetylcholine receptor.

  Neuroscience 20040101

• Interactions between grapefruit juice and cardiovascular drugs.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20040101

• Effect of time of administration on cholesterol-lowering by psyllium: a randomized cross-over study in normocholesterolemic or slightly hypercholesterolemic subjects.

  Nutrition journal 20040101

• [Lovastatin effect on ergosterol production and growth of Tolypocladium inflatum 106].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20040101

• The pivotal role of cholesterol absorption inhibitors in the management of dyslipidemia.

  Lipids in health and disease 20040101

• Influence of lovastatin on BCL-2 and BAX expression by plasma cells and T lymphocytes in short-term cultures of multiple myeloma bone marrow mononuclear cells.

  Polish journal of pharmacology 20040101

• Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana.

  Genome biology 20040101

• The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.

  Genome biology 20040101

• Lipoprotein lipase locus and progression of atherosclerosis in coronary-artery bypass grafts.

  Genetics in medicine : official journal of the American College of Medical Genetics 20040101

• Effect of 3,4-di(OH)-cinnamate synthetic derivative on plasma and hepatic cholesterol level and antioxidant enzyme activities in high cholesterol-fed rats.

  Journal of biochemical and molecular toxicology 20040101

• Cytoskeletal actin degradation induced by lovastatin in cardiomyocytes is mediated through caspase-2.

  Cell biology international 20040101

• The need for a large-scale trial of fibrate therapy in diabetes: the rationale and design of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. [ISRCTN64783481].

  Cardiovascular diabetology 20040101

• [Thrombocytic hemostasis in hypertensive patients with metabolic syndrome and its correction with lovastatin].

  Klinicheskaia meditsina 20040101

• Anti-Plasmodium activity of ceramide analogs.

  Malaria journal 20040101

• Lipid metabolism in zebrafish.

  Methods in cell biology 20040101

• [Mevastatin induced apoptosis in U266 human myeloma cell line].

  Magyar onkologia 20040101

• KGF-induced motility of breast cancer cells is dependent on Grb2 and Erk1,2.

  Clinical & experimental metastasis 20040101

• [Screening of natural compounds with hypolipidemic activity].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20040101

• [Estimation of the efficacy of screened natural hypolipidemic compounds in a model of rabbit hypercholesterolemia].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20040101

• Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells.

  Cancer letters 20031230

• Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation.

  Proceedings of the National Academy of Sciences of the United States of America 20031223

• Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors.

  Toxicology and applied pharmacology 20031215

• Statins induce suppressor of cytokine signaling-3 in macrophages.

  FEBS letters 20031204

• Two derivative spectrophotometric methods for the simultaneous determination of lovastatin combined with three antioxidants.

  Journal of pharmaceutical and biomedical analysis 20031204

• Statin-mediated correction of STAT1 signaling and inducible nitric oxide synthase expression in cystic fibrosis epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20031201

• Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade.

  American journal of physiology. Renal physiology 20031201

• Methyl palmitate: a novel product of the Medfly (Ceratitis capitata) corpus allatum.

  Insect biochemistry and molecular biology 20031201

• Chinese red rice-induced myopathy.

  Southern medical journal 20031201

• [Ezetimibe: from pharmacology to clinical trials].

  Annales d'endocrinologie 20031201

• Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

  British journal of cancer 20031117

• Protein geranylgeranylation is critical for the regulation of survival and proliferation of lymphoma tumor cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20031115

• Inhibition of hydroxymethylglutaryl-coenzyme a reductase reduces Th1 development and promotes Th2 development.

  Circulation research 20031114

• Rosuvastatin in the primary prevention of cardiovascular disease among patients with low levels of low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: rationale and design of the JUPITER trial.

  Circulation 20031111

• Effects of statins on platelet inhibition by a high loading dose of clopidogrel.

  Circulation 20031104

• Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels.

  Blood 20031101

• Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells.

  Journal of cancer research and clinical oncology 20031101

• 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk.

  General and comparative endocrinology 20031101

• Effects of cholesterol-lowering foods versus lovastatin on serum lipids and C-reactive protein.

  Current atherosclerosis reports 20031101

• HMG-CoA reductase inhibition reduces the proinflammatory activation of human vascular smooth muscle cells by the terminal complement factor C5b-9.

  Basic research in cardiology 20031101

• FK506 potentiates NGF-induced neurite outgrowth via the Ras/Raf/MAP kinase pathway.

  British journal of pharmacology 20031101

• Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha.

  Free radical biology & medicine 20031101

• Effect of HMG-CoA reductase inhibitors on reduction of panel reactivity.

  Transplantation proceedings 20031101

• Improvement of monacolin K, gamma-aminobutyric acid and citrinin production ratio as a function of environmental conditions of Monascus purpureus NTU 601.

  Journal of industrial microbiology & biotechnology 20031101

• Cell-cycle gene expression in lovastatin-induced medulloblastoma apoptosis.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20031101

• Bioconversion of compactin into pravastatin by Streptomyces sp.

  Biotechnology letters 20031101

• A multicenter, randomized, double-blind clinical trial comparing the low-density lipoprotein cholesterol-lowering ability of lovastatin 10, 20, and 40 mg/d with fluvastatin 20 and 40 mg/d.

  Clinical therapeutics 20031101

• p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases.

  The Journal of biological chemistry 20031031

• Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells.

  British journal of cancer 20031020

• Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.

  International journal of oncology 20031001

• Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study.

  European heart journal 20031001

• Protective effects of lovastatin on vascular endothelium injured by low density lipoprotein.

  Acta pharmacologica Sinica 20031001

• The bisphosphonate pamidronate is a potent inhibitor of Ewing's sarcoma cell growth in vitro.

  Anti-cancer drugs 20031001

• Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARgamma2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures.

  Bone 20031001

• Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase lower fecundity in the German cockroach: correlation between the effects on fecundity in vivo with the inhibition of enzymatic activity in embryo cells.

  Pest management science 20031001

• The mevalonate synthesis pathway as a therapeutic target in cancer.

  Clinical orthopaedics and related research 20031001

• Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells.

  Atherosclerosis 20031001

• All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells.

  Atherosclerosis 20031001

• Antifungal activity of fluconazole in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicans.

  Medical mycology 20031001

• [Effect of space flight on yield of Monascus purpureus].

  Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering 20031001

• Cholesterol oxidase and the hydroxymethylglutaryl coenzyme A reductase inhibitor mevinolin perturb endocytic trafficking in cultured vascular smooth muscle cells.

  Journal of submicroscopic cytology and pathology 20031001

• Small-molecule cyclin-dependent kinase modulators.

  Oncogene 20030929

• cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase.

  Archives of biochemistry and biophysics 20030915

• Lactonase and lactonizing activities of human serum paraoxonase (PON1) and rabbit serum PON3.

  Biochemical pharmacology 20030915

• Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion.

  Virology 20030915

• Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2).

  The Journal of biological chemistry 20030905

• Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice.

  Neurobiology of aging 20030901

• Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure.

  Journal of immunology (Baltimore, Md. : 1950) 20030901

• Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis.

  Endocrinology 20030901

• Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis.

  Basic research in cardiology 20030901

• Lovastatin induces relaxation and inhibits L-type Ca(2+) current in the rat basilar artery.

  Pharmacology & toxicology 20030901

• Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells.

  Cardiovascular research 20030901

• Statins differ in their ability to block NF-kappaB activation in human blood monocytes.

  International journal of clinical pharmacology and therapeutics 20030901

• What's new in lipid management?

  Pharmacotherapy 20030901

• Inhibition of lovastatin on proliferation and expression of proinflammatory cytokines in cultured human glomerular mesangial cells.

  Chinese medical journal 20030901

• Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease.

  Pharmacopsychiatry 20030901

• Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives.

  Hypertension research : official journal of the Japanese Society of Hypertension 20030901

• Chronic pancreatitis.

  Current opinion in gastroenterology 20030901

• Transport mechanism for lovastatin acid in bovine kidney NBL-1 cells: kinetic evidences imply involvement of monocarboxylate transporter 4.

  International journal of pharmaceutics 20030827

• Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial.

  Circulation 20030826

• Analytical methods for the quantitative determination of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in biological samples.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030815

• Cholesterol deficiency increases the vulnerability of hippocampal glia in primary culture to glutamate-induced excitotoxicity.

  Neurochemistry international 20030801

• [Cholesterol-reducing medications-a new therapeutic option for multiple sclerosis? Statins as immunomodulators].

  Der Nervenarzt 20030801

• [Statin-induced Parkinson's-syndrome. Reader's letter on the article by J. Finsterer in 'Der Nervenarzt' (2003) 74:115-122].

  Der Nervenarzt 20030801

• Treatment with lovastatin, cholestyramine or niacin alters K-ras membrane association in mouse lung in a strain-dependent manner: results in females.

  Biochemical pharmacology 20030801

• Simvastatin.

  Acta crystallographica. Section C, Crystal structure communications 20030801

• HMG-CoA reductase inhibitors induce apoptosis in neointima-derived vascular smooth muscle cells.

  Atherosclerosis 20030801

• Mevastatin suppresses lipopolysaccharide-induced Rac activation in the human monocyte cell line THP-1.

  Surgery 20030801

• Lovastatin causes sensitization of HeLa cells to ionizing radiation-induced apoptosis by the abrogation of G2 blockage.

  International journal of radiation biology 20030801

• Effect of red mold rice supplements on serum and egg yolk cholesterol levels of laying hens.

  Journal of agricultural and food chemistry 20030730

• Identifying the factors and signal pathways necessary for anchorage-independent growth of Ha-ras oncogene-transformed NIH/3T3 cells.

  Life sciences 20030725

• Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin.

  Biochemical and biophysical research communications 20030725

• Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein.

  JAMA 20030723

• Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells.

  The Journal of biological chemistry 20030718

• Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells.

  Molecular vision 20030717

• Osteoblast-derived oxysterol is a migration-inducing factor for human breast cancer cells.

  The Journal of biological chemistry 20030711

• Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin.

  Chemical communications (Cambridge, England) 20030707

• Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells.

  International journal of oncology 20030701

• Mechanism of simvastatin on induction of heat shock protein in osteoblasts.

  Archives of biochemistry and biophysics 20030701

• Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors.

  Nature reviews. Drug discovery 20030701

• Statins sentence thyroid cancer cells to death rho.

  The Journal of clinical endocrinology and metabolism 20030701

• Lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, induces apoptosis and differentiation in human anaplastic thyroid carcinoma cells.

  The Journal of clinical endocrinology and metabolism 20030701

• Therapeutic implications of recent ATP III guidelines and the important role of combination therapy in total dyslipidemia management.

  Current opinion in cardiology 20030701

• Statin-associated memory loss: analysis of 60 case reports and review of the literature.

  Pharmacotherapy 20030701

• [Effect of lovastatin on the expression of IkappaBalpha and cell-cycle regulating protein in MCF-7 cells].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20030701

• Increase in cholesterol and cholesterol oxidation products, and role of cholesterol oxidation products in kainate-induced neuronal injury.

  Brain pathology (Zurich, Switzerland) 20030701

• Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis.

  Lipids 20030701

• [Efficacy and safety of combined statin-fenofibrates therapy compared with monotherapy in patients with mixed hyperlipidemia and high risk of coronary heart disease].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030701

• Biochemical studies on marine fish oil part-I: effects of fish oil and lipid lowering drugs on HDL/LDL cholesterol levels.

  Pakistan journal of pharmaceutical sciences 20030701

• Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis.

  BMJ (Clinical research ed.) 20030628

• Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients.

  Neurology 20030624

• Of cancer and cholesterol: studies elucidate anticancer mechanisms of statins.

  Journal of the National Cancer Institute 20030618

• Monoterpene regulation of Ras and Ras-related protein expression.

  Journal of lipid research 20030601

• Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits.

  Journal of ethnopharmacology 20030601

• Cost effectiveness of statin therapy for the primary prevention of major coronary events in individuals with type 2 diabetes.

  Diabetes care 20030601

• Biosynthetic maturation of the corpus allatum of the female adult medfly, Ceratitis capitata, and its putative control.

  Journal of insect physiology 20030601

• Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance.

  Clinical pharmacology and therapeutics 20030601

• Collision-induced dissociation of the negative ions of simvastatin hydroxy acid and related species.

  Journal of mass spectrometry : JMS 20030601

• Therapeutic potential of lovastatin in multiple sclerosis.

  Journal of neurology 20030601

• Hypolipidemic and anti-atherogenic effects of long-term Cholestin (Monascus purpureus-fermented rice, red yeast rice) in cholesterol fed rabbits.

  The Journal of nutritional biochemistry 20030601

• Current perspectives on statins.

  Journal of the Indian Medical Association 20030601

• Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase.

  The Journal of biological chemistry 20030530

• Activation of insulin-like growth factor II signaling by mutant type p53: physiological implications for potentiation of IGF-II signaling by p53 mutant 249.

  Molecular and cellular endocrinology 20030530

• Determination of cholesterol-lowering statin drugs in aqueous samples using liquid chromatography-electrospray ionization tandem mass spectrometry.

  Journal of chromatography. A 20030523

• Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).

  The Journal of biological chemistry 20030516

• HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes.

  Circulation research 20030516

• Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses.

  Blood 20030501

• Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501

• Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20030501

• Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells.

  Journal of hepatology 20030501

• Treating dyslipidemic patients with lipid-modifying and combination therapies.

  Pharmacotherapy 20030501

• Acute pancreatitis due to pravastatin therapy.

  JOP : Journal of the pancreas 20030501

• Three new drugs for hyperlipidemia.

  Connecticut medicine 20030501

• Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen.

  Cellular immunology 20030501

• Lovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production.

  Cellular immunology 20030501

• Ezetimibe: a novel option for lowering cholesterol.

  Expert review of cardiovascular therapy 20030501

• Inhibition of pancreatic stellate cell activation by the hydroxymethylglutaryl coenzyme A reductase inhibitor lovastatin.

  Biochemical pharmacology 20030415

• Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415

• High-density lipoprotein subpopulations in pathologic conditions.

  The American journal of cardiology 20030403

• Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training.

  American journal of physiology. Heart and circulatory physiology 20030401

• A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.

  Nature genetics 20030401

• Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia.

  The Journal of laboratory and clinical medicine 20030401

• Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease.

  Archives of neurology 20030401

• Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction.

  Molecular and cellular biochemistry 20030401

• Safety and statin therapy: reconsidering the risks and benefits.

  Archives of internal medicine 20030324

• Differential effects of lipid-lowering therapies on stroke prevention: a meta-analysis of randomized trials.

  Archives of internal medicine 20030324

• Mevastatin can cause G1 arrest and induce apoptosis in pulmonary artery smooth muscle cells through a p27Kip1-independent pathway.

  Circulation research 20030321

• Comparison of once-daily, niacin extended-release/lovastatin with standard doses of atorvastatin and simvastatin (the ADvicor Versus Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE]).

  The American journal of cardiology 20030315

• Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata.

  Journal of biotechnology 20030306

• Determination of Simvastatin in human plasma by liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030305

• Three new drugs for hyperlipidemia.

  The Medical letter on drugs and therapeutics 20030303

• Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signaling.

  The Journal of urology 20030301

• Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress.

  Arteriosclerosis, thrombosis, and vascular biology 20030301

• Statin effects on cholesterol micro-domains in brain plasma membranes.

  Biochemical pharmacology 20030301

• Effects of hypolipidemic treatment on serum markers of vascular inflammation in dyslipidemic men.

  Medical science monitor : international medical journal of experimental and clinical research 20030301

• [Effects of lovastatin on proliferation and gap junctional intercellular communication of human breast cancer cell MCF-7].

  Ai zheng = Aizheng = Chinese journal of cancer 20030301

• Treating dyslipidemia with statins: the risk-benefit profile.

  American heart journal 20030301

• Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models.

  Carcinogenesis 20030301

• A dose-ranging study of a new, once-daily, dual-component drug product containing niacin extended-release and lovastatin.

  Clinical cardiology 20030301

• [Determination of total lovastatin in red rice].

  Wei sheng yan jiu = Journal of hygiene research 20030301

• Regulation of osteoclast differentiation by statins.

  Journal of musculoskeletal & neuronal interactions 20030301

• Lovastatin stimulates human vascular smooth muscle cell expression of bone morphogenetic protein-2, a potent inhibitor of low-density lipoprotein-stimulated cell growth.

  Biochemical and biophysical research communications 20030227

• Efficacy and safety of ezetimibe coadministered with lovastatin in primary hypercholesterolemia.

  The American journal of cardiology 20030215

• Inhibition of cdk2 activating phosphorylation by mevastatin.

  The Journal of biological chemistry 20030214

• Mevastatin can increase toxicity in primary AMLs exposed to standard therapeutic agents, but statin efficacy is not simply associated with ras hotspot mutations or overexpression.

  Leukemia research 20030201

• Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.

  Nature biotechnology 20030201

• Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes.

  Journal of neurochemistry 20030201

• Inhibitor studies of isopentenyl pyrophosphate biosynthesis in suspension cultures of the yew Taxus chinensis var. mairei.

  Biotechnology and applied biochemistry 20030201

• Statins can inhibit proliferation of human breast cancer cells in vitro.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030201

• Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.

  Organic & biomolecular chemistry 20030107

• The synaptophysin/synaptobrevin interaction critically depends on the cholesterol content.

  Journal of neurochemistry 20030101

• Cytochrome P450 drug interactions within the HMG-CoA reductase inhibitor class: are they clinically relevant?

  Drug safety 20030101

• Niacin-ER and lovastatin treatment of hypercholesterolemia and mixed dyslipidemia.

  The Annals of pharmacotherapy 20030101

• The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030101

• HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells.

  Arteriosclerosis, thrombosis, and vascular biology 20030101

• Synergistic activation of human LDL receptor expression by SCAP ligand and cytokine oncostatin M.

  Arteriosclerosis, thrombosis, and vascular biology 20030101

• Cerivastatin and atorvastatin inhibit IL-3-dependent differentiation and IgE-mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3.

  Journal of leukocyte biology 20030101

• Ubiquinone does not rescue acute myeloid leukemia cells from growth inhibition by statins.

  Leukemia 20030101

• Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease.

  The European journal of neuroscience 20030101

• The statins as anticancer agents.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030101

• Comparing HMG-CoA reductase inhibitors.

  Clinical cardiology 20030101

• Production of the secondary metabolites gamma-aminobutyric acid and monacolin K by Monascus.

  Journal of industrial microbiology & biotechnology 20030101

• The role of the ubiquitination-proteasome pathway in breast cancer: applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancer.

  Breast cancer research : BCR 20030101

• Effects of policosanol and lovastatin in patients with intermittent claudication: a double-blind comparative pilot study.

  Angiology 20030101

• Cerivastatin: a cellular and molecular drug for the future?

  Cellular and molecular life sciences : CMLS 20030101

• Production and purification of statins from Pleurotus ostreatus (Basidiomycetes) strains.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

• An economic analysis of the Atorvastatin Comparative Cholesterol Efficacy and Safety Study (ACCESS).

  PharmacoEconomics 20030101

• Lovastatin extended release: a review of its use in the management of hypercholesterolaemia.

  Drugs 20030101

• Lopinavir/ritonavir: a review of its use in the management of HIV infection.

  Drugs 20030101

• The role of intracellular cholesterol on the processing of the beta-amyloid precursor protein.

  The journal of nutrition, health & aging 20030101

• Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells.

  Lipids in health and disease 20030101

• Lymphocyte function-associated antigen-1 blockade by statins: molecular basis and biological relevance.

  Endothelium : journal of endothelial cell research 20030101

• Does simvastatin stimulate bone formation in vivo?

  BMC musculoskeletal disorders 20030101

• 4-hydroxycinnamate lowers plasma and hepatic lipids without changing antioxidant enzyme activities.

  Annals of nutrition & metabolism 20030101

• Variable influence of statins on isoprostanes in hyperlipidemia.

  Advances in experimental medicine and biology 20030101

• Melanoma chemoprevention: a role for statins or fibrates?

  American journal of therapeutics 20030101

• Characterization of a non-pigment producing Monascus purpureus mutant strain.

  Antonie van Leeuwenhoek 20030101

• Twice-daily amprenavir 1200 mg versus amprenavir 600 mg/ritonavir 100 mg, in combination with at least 2 other antiretroviral drugs, in HIV-1-infected patients.

  BMC infectious diseases 20030101

• Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin.

  Cell stress & chaperones 20030101

• HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages.

  Journal of biomedical science 20030101

• Potential nontraditional applications of statins.

  The Annals of pharmacotherapy 20030101

• Comparison of the cholesterol-lowering effects and toxicity of D-003 and lovastatin in normocholesterolaemic rabbits.

  Drugs in R&D 20030101

• Microencapsulation of lipid nanoparticles containing lipophilic drug.

  Journal of microencapsulation 20030101

• Effect of statins combined with estradiol on the proliferation of human receptor-positive and receptor-negative breast cancer cells.

  Menopause (New York, N.Y.) 20030101

• HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection.

  BMC cardiovascular disorders 20030101

• HIV protease inhibitors and dyslipidemia.

  AIDS reviews 20030101

• Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions.

  Chemical record (New York, N.Y.) 20030101

• Cholesterol-lowering action of policosanol compares well to that of pravastatin and lovastatin.

  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20030101

• A review of anabolic therapies for osteoporosis.

  Arthritis research & therapy 20030101

• Clinical pharmacokinetics of statins.

  Methods and findings in experimental and clinical pharmacology 20030101

• Behavioral implications of lowering cholesterol levels: a double-blind pilot study.

  Psychosomatics 20030101

• Novel small molecule cyclin-dependent kinases modulators in human clinical trials.

  Cancer biology & therapy 20030101

• Molecular regulation of cholesterol biosynthesis: implications in carcinogenesis.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20030101

• Pharmacological comparison of the statins.

  Arzneimittel-Forschung 20030101

• Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats.

  Journal of medicinal food 20030101

• Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.

  Clinical & experimental metastasis 20030101

• Once-daily niacin extended release/lovastatin combination tablet has more favorable effects on lipoprotein particle size and subclass distribution than atorvastatin and simvastatin.

  Preventive cardiology 20030101

• Weight uniformity of split tablets required by a Veterans Affairs policy.

  Journal of managed care pharmacy : JMCP 20030101

• The safety of over-the-counter niacin. A randomized placebo-controlled trial [ISRCTN18054903].

  BMC clinical pharmacology 20030101

• Ezetimibe: a first-in-class, novel cholesterol absorption inhibitor.

  Cardiovascular drug reviews 20030101

• Statin stimulates bone morphogenetic protein-2, aggrecan, and type 2 collagen gene expression and proteoglycan synthesis in rat chondrocytes.

  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20030101

• Hypergravity-induced changes in gene expression in Arabidopsis hypocotyls.

  Advances in space research : the official journal of the Committee on Space Research (COSPAR) 20030101

• Cholesterol regulates ABCD2 gene expression: implications for X-linked adrenoleukodstrophy.

  Advances in experimental medicine and biology 20030101

• [Screening of natural immunosuppressors by their ability to modify steroid synthesis in hepatocytes].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20030101

• Differences between lovastatin and simvastatin hydrolysis in healthy male and female volunteers:gut hydrolysis of lovastatin is twice that of simvastatin.

  TheScientificWorldJournal 20030101

• Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials.

  BMC family practice 20030101

• [Flotation mass-spectra and surface potential of low density lipoprotein particles of hyperlipidemic patients after forced abolishment of lavostatin treatment].

  Biomeditsinskaia khimiia 20030101

• Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells.

  Experimental & molecular medicine 20021231

• Receptor-dependent regulation of the CYP3A4 gene.

  Toxicology 20021227

• Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins.

  Brain research 20021220

• 2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.

  Journal of medicinal chemistry 20021219

• Chelation-controlled reduction: stereoselective formation of syn-1,3-diols and synthesis of compactin and mevinolin lactone.

  The Journal of organic chemistry 20021213

• Production of lovastatin examined by an integrated approach based on chemometrics and DOSY-NMR.

  Biotechnology and bioengineering 20021205

• Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20021201

• Monocarboxylate transporter mediates uptake of lovastatin acid in rat cultured mesangial cells.

  Journal of pharmaceutical sciences 20021201

• Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway.

  Planta 20021201

• X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha.

  Structure (London, England : 1993) 20021201

• Niacin extended-release/lovastatin: combination therapy for lipid disorders.

  Expert opinion on pharmacotherapy 20021201

• Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms.

  The Journal of investigative dermatology 20021201

• Cerivastatin, a HMG-CoA reductase inhibitor, reduces plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity.

  Japanese journal of pharmacology 20021201

• Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content.

  Plant & cell physiology 20021201

• An examination of the effect of cytochrome P450 drug interactions of hydroxymethylglutaryl-coenzyme A reductase inhibitors on health care utilization: a Canadian population-based study.

  Clinical therapeutics 20021201

• Enzyme inhibitors to increase poly-3-hydroxybutyrate production by transgenic tobacco.

  Bioscience, biotechnology, and biochemistry 20021201

• Toward a role for statins in immunomodulation.

  Molecular interventions 20021201

• [Treatment with statins: further data from the Heart Protection Study].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20021130

• Side effects of statins--prevalence, relevance, consequences.

  Wiener klinische Wochenschrift 20021130

• Statin-induced myositis migrans.

  Wiener klinische Wochenschrift 20021130

• Immunomodulation of experimental autoimmune encephalomyelitis in the Lewis rats by Lovastatin.

  Neuroscience letters 20021129

• Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis.

  The Journal of biological chemistry 20021122

• Combination therapy for combined dyslipidemia.

  The American journal of cardiology 20021120

• Isoprenoids influence expression of Ras and Ras-related proteins.

  Biochemistry 20021119

• The effects of lovastatin and simvastatin on the diurnal periodicity of plasma mevalonate concentrations in patients with heterozygous familial hypercholesterolemia.

  Atherosclerosis 20021101

• Early statin therapy for acute coronary syndromes.

  The Annals of pharmacotherapy 20021101

• In response to Furst et al, 'Possible association of QTc interval prolongation with co-administration of quetiapine and lovastatin'.

  Biological psychiatry 20021101

• Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021101

• Simvastatin improves fracture healing in mice.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021101

• Lipid-lowering therapy after coronary artery bypass grafting: time for more aggressive intervention.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20021101

• Functional analysis of mlcR, a regulatory gene for ML-236B (compactin) biosynthesis in Penicillium citrinum.

  Molecular genetics and genomics : MGG 20021101

• Lovastatin does not accentuate but is rather additive to palmitate-induced apoptosis in cardiomyocytes.

  Prostaglandins, leukotrienes, and essential fatty acids 20021101

• Geranylgeranyl pyrophosphate counteracts the cataractogenic effect of lovastatin on cultured rat lenses.

  Experimental eye research 20021101

• Preclinical pharmacokinetics of statins.

  Methods and findings in experimental and clinical pharmacology 20021101

• Rhabdomyolysis due to red yeast rice (Monascus purpureus) in a renal transplant recipient.

  Transplantation 20021027

• Mutant K-ras oncogene regulates steroidogenesis of normal human adrenocortical cells by the RAF-MEK-MAPK pathway.

  British journal of cancer 20021021

• Cholesterol regulates ABCD2 expression: implications for the therapy of X-linked adrenoleukodystrophy.

  Human molecular genetics 20021015

• Statins as immunomodulators: comparison with interferon-beta 1b in MS.

  Neurology 20021008

• Comparing the effects of five different statins on the HDL subpopulation profiles of coronary heart disease patients.

  Atherosclerosis 20021001

• Potent suppression of proliferation of a10 vascular smooth muscle cells by combined treatment with lovastatin and 3-allylfarnesol, an inhibitor of protein farnesyltransferase.

  The Journal of pharmacology and experimental therapeutics 20021001

• Inhibition of glucose- and calcium-induced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation.

  The Journal of pharmacology and experimental therapeutics 20021001

• A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system.

  The Journal of pharmacology and experimental therapeutics 20021001

• The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide.

  International journal of molecular medicine 20021001

• Rhabdomyolysis with concurrent atorvastatin and diltiazem.

  The Annals of pharmacotherapy 20021001

• Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are able to reduce superoxide anion production by NADPH oxidase in THP-1-derived monocytes.

  Journal of cardiovascular pharmacology 20021001

• Statin-associated myopathy with normal creatine kinase levels.

  Annals of internal medicine 20021001

• Summaries for patients. Muscle abnormalities in four patients taking statins to treat unfavorable cholesterol levels.

  Annals of internal medicine 20021001

• On-line analysis of the (13)CO(2) labeling of leaf isoprene suggests multiple subcellular origins of isoprene precursors.

  Planta 20021001

• Frequency of new coronary events in older persons with peripheral arterial disease and serum low-density lipoprotein cholesterol > or = 125 mg/dl treated with statins versus no lipid-lowering drug.

  The American journal of cardiology 20021001

• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

  Endocrine reviews 20021001

• Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

• Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome.

  Arthritis and rheumatism 20021001

• [Effect of lovastatin on proliferation and extracellular matrix secretion of rat hepatic stellate cells in vitro].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20021001

• Lovastatin alters biliary lipid composition and dissolves gallstones: a long-term study in prairie dogs.

  Digestive diseases and sciences 20021001

• Lovastatin-stimulated superinduction of E-selectin, ICAM-1 and VCAM-1 in TNF-alpha activated human vascular endothelial cells.

  Atherosclerosis 20020901

• Influence of atorvastatin and simvastatin on apolipoprotein B metabolism in moderate combined hyperlipidemic subjects with low VLDL and LDL fractional clearance rates.

  Atherosclerosis 20020901

• Clinical implications of statin event trials.

  Current atherosclerosis reports 20020901

• Mechanisms of NOS2 regulation by Rho GTPase signaling in airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20020901

• Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway.

  Cell death and differentiation 20020901

• The effects of lovastatin on proteasome activities in highly purified rabbit 20 S proteasome preparations and mouse MC3T3-E1 osteoblastic cells.

  Metabolism: clinical and experimental 20020901

• Policosanol safely down-regulates HMG-CoA reductase - potential as a component of the Esselstyn regimen.

  Medical hypotheses 20020901

• Update on the management of dyslipidemia.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020901

• Niacin-based therapy for dyslipidemia: past evidence and future advances.

  The American journal of managed care 20020901

• Effect of increased dosage of the ML-236B (compactin) biosynthetic gene cluster on ML-236B production in Penicillium citrinum.

  Molecular genetics and genomics : MGG 20020901

• Management of dyslipidemia in the primary prevention of coronary heart disease.

  Current opinion in cardiology 20020901

• Cholesterol attenuates the membrane perturbing properties of beta-amyloid peptides.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20020901

• Diabetes and the role of isoprenoid biosynthesis.

  FEBS letters 20020814

• Lovastatin downregulates renal myofibroblast function in vitro.

  Nephron 20020801

• Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin.

  Biochemical pharmacology 20020801

• Pharmacology of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), including rosuvastatin and pitavastatin.

  Journal of clinical pharmacology 20020801

• HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells.

  Clinical science (London, England : 1979) 20020801

• Cholesterol and Alzheimer's disease.

  Biochemical Society transactions 20020801

• Proteome analysis of Aspergillus nidulans reveals proteins associated with the response to the antibiotic concanamycin A, produced by Streptomyces species.

  Molecular genetics and genomics : MGG 20020801

• Determination of lovastatin and simvastatin in pharmaceutical dosage forms by MEKC.

  Journal of pharmaceutical and biomedical analysis 20020720

• Targeting the cell cycle for cancer therapy.

  British journal of cancer 20020715

• Simvastatin, an HMG-CoA reductase inhibitor, induces the synthesis and secretion of apolipoprotein AI in HepG2 cells and primary hamster hepatocytes.

  Atherosclerosis 20020701

• Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas.

  Neoplasia (New York, N.Y.) 20020701

• Long-term prevention of premature coronary atherosclerosis in homozygous familial hypercholesterolemia.

  The Journal of pediatrics 20020701

• The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells.

  Leukemia 20020701

• Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: effects are highly mouse strain dependent.

  Biochemical pharmacology 20020701

• Lovastatin potentiates antitumor activity of doxorubicin in murine melanoma via an apoptosis-dependent mechanism.

  International journal of cancer 20020701

• Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum.

  Molecular genetics and genomics : MGG 20020701

• Lovastatin increases longitudinal bone growth and bone morphogenetic protein-2 levels in the growth plate of Sprague-Dawley rats.

  European journal of pediatrics 20020701

• Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells.

  Biochemical and biophysical research communications 20020628

• The liver and lovastatin.

  The American journal of cardiology 20020615

• By the way, doctor. I read that they're now selling a cheaper version of Mevacor. But I've also heard that Mevacor isn't as effective as the other statins. What do you think?

  Harvard health letter 20020601

• Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects.

  Journal of neuroscience research 20020601

• A clinical and experimental study on the protective effects of jiangzhi tongmai fang on endothelial injury.

  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20020601

• Policosanol: a new treatment for cardiovascular disease?

  Alternative medicine review : a journal of clinical therapeutic 20020601

• P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype.

  Leukemia & lymphoma 20020601

• A randomized, double-blind comparison of cerivastatin and lovastatin for treatment of primary hypercholesterolemia.

  Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 20020601

• Lovastatin induces cell death in cardiomyocytes that is not reversible by coenzyme Q 10.

  Pharmacology & toxicology 20020601

• Comparison of effect of intensive lipid lowering with atorvastatin to less intensive lowering with lovastatin on C-reactive protein in patients with stable angina pectoris and inducible myocardial ischemia.

  The American journal of cardiology 20020515

• Statins and risk of polyneuropathy: a case-control study.

  Neurology 20020514

• Low- and high-density lipoprotein cholesterol and ischemic cerebrovascular disease: the bezafibrate infarction prevention registry.

  Archives of internal medicine 20020513

• Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status.

  The Journal of biological chemistry 20020510

• Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.

  The Journal of biological chemistry 20020503

• Rhabdomyolysis after concomitant use of cyclosporine, simvastatin, gemfibrozil, and itraconazole.

  The Annals of pharmacotherapy 20020501

• Pharmacokinetics of lovastatin extended-release dosage form (Lovastatin XL) in healthy volunteers.

  Biopharmaceutics & drug disposition 20020501

• Immunosuppressive effects of statins.

  Atherosclerosis. Supplements 20020501

• Pharmacological interactions of statins.

  Atherosclerosis. Supplements 20020501

• Diabetic dyslipidemia.

  Atherosclerosis. Supplements 20020501

• The choice of hormone replacement therapy or statin therapy in the treatment of hyperlipidemic postmenopausal women.

  Atherosclerosis. Supplements 20020501

• Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20020501

• Expression of Nedd5, a mammalian septin, in human brain tumors.

  Journal of neuro-oncology 20020501

• Plasma homocysteine concentration, statin therapy, and the risk of first acute coronary events.

  Circulation 20020416

• From the Food and Drug Administration.

  JAMA 20020403

• Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae.

  Atherosclerosis 20020401

• Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens.

  International journal of oncology 20020401

• CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase.

  Blood 20020401

• Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients.

  Frontiers in bioscience : a journal and virtual library 20020401

• Effects of hypocholesterolaemic agents on the expression and activity of 3-hydroxy-3-methylglutaryl-CoA reductase in the fat body of the German cockroach.

  Archives of insect biochemistry and physiology 20020401

• Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs.

  Applied microbiology and biotechnology 20020401

• Withdrawal of statins increases event rates in patients with acute coronary syndromes.

  Circulation 20020326

• Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.

  The Journal of biological chemistry 20020322

• Long-term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia.

  The American journal of cardiology 20020315

• Myopathy and rhabdomyolysis with lipid-lowering drugs.

  Toxicology letters 20020310

• Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases.

  Circulation research 20020308

• Managing dyslipidemia in the high-risk patient.

  The American journal of cardiology 20020307

• Analytical method for monitoring concentrations of cyclosporin and lovastatin in vitro in an everted rat intestinal sac absorption model.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020305

• A novel concept to preserve the beneficial effects of hormone replacement therapy in bilaterally female ovariectomized rats: role of lovastatin therapy.

  Pharmacological research 20020301

• 3-Morpholinosydnonimine hydrochloride induces p53-dependent apoptosis in murine primary neural cells: a critical role for p21(ras)-MAPK-p19(ARF) pathway.

  Nitric oxide : biology and chemistry 20020301

• Effect of colesevelam on lovastatin pharmacokinetics.

  The Annals of pharmacotherapy 20020301

• Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells.

  Carcinogenesis 20020301

• Simvastatin and lovastatin, but not pravastatin, interact with MDR1.

  The Journal of pharmacy and pharmacology 20020301

• Assessment of ADRs associated with lipid-lowering agents recorded in the Department of Internal Medicine, University Hospital, Jena.

  International journal of clinical pharmacology and therapeutics 20020301

• C-reactive protein: from acute phase reactant to cardiovascular disease risk factor.

  MLO: medical laboratory observer 20020301

• [Stimulation of bone formation by anti-hyperlipidemic agent statins and its mechanism of action].

  Nihon rinsho. Japanese journal of clinical medicine 20020301

• HMG-CoA reductase inhibitors reduce interleukin-6 synthesis in human vascular smooth muscle cells.

  Cardiovascular drugs and therapy 20020301

• Antioxidant treatment of therapy-resistant idiopathic membranous nephropathy with probucol: a pilot study.

  Wiener klinische Wochenschrift 20020227

• Potentiating antitumor effects of a combination therapy with lovastatin and butyrate in the Lewis lung carcinoma model in mice.

  International journal of cancer 20020220

• Goals of statin conversion program.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020215

• Therapy and clinical trials.

  Current opinion in lipidology 20020201

• Caveolae and cholesterol distribution in vascular smooth muscle cells of different phenotypes.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20020201

• Comparative pharmacokinetics of lovastatin extended-release tablets and lovastatin immediate-release tablets in humans.

  Journal of clinical pharmacology 20020201

• 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis.

  Gastroenterology 20020201

• Possible association of QTc interval prolongation with co-administration of quetiapine and lovastatin.

  Biological psychiatry 20020201

• Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest.

  Leukemia 20020201

• FDA adverse event reports on statin-associated rhabdomyolysis.

  The Annals of pharmacotherapy 20020201

• The subcellular localization of an unusual rice calmodulin isoform, OsCaM61, depends on its prenylation status.

  Plant molecular biology 20020201

• Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells.

  Lipids 20020201

• Lipid-lowering long-term effects of six different statins in hypercholesterolemic renal transplant patients under cyclosporine immunosuppression.

  Transplantation proceedings 20020201

• Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue.

  Breast cancer research and treatment 20020201

• [Inhibitory effects of lovastatin on the proliferation and cell cycle phase of cultured human glomerular mesangial cells in vitro].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020201

• Dose response, safety, and efficacy of an extended-release formulation of lovastatin in adults with hypercholesterolemia.

  The American journal of cardiology 20020115

• A general assessment of the safety of HMG CoA reductase inhibitors (statins).

  Current atherosclerosis reports 20020101

• Cyclin b1 promoter activity and functional cdk1 complex formation in G1 phase of human breast cancer cells.

  Cell biology international 20020101

• HMG CoA reductase inhibitors affect the fibrinolytic system of human vascular cells in vitro: a comparative study using different statins.

  British journal of pharmacology 20020101

• Cholesterol, essential fatty acids, and suicide.

  Pharmacopsychiatry 20020101

• A multiple-dose pharmacodynamic, safety, and pharmacokinetic comparison of extended- and immediate-release formulations of lovastatin.

  Clinical therapeutics 20020101

• Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli.

  Cellular microbiology 20020101

• Effect of roxithromycin on the pharmacokinetics of lovastatin in volunteers.

  European journal of clinical pharmacology 20020101

• [Schistosoma mansoni: the action of lovastatin on the murine model].

  Revista da Sociedade Brasileira de Medicina Tropical 20020101

• Effect of simvastatin on bone markers in osteopenic women: a placebo-controlled, dose-ranging trial [ISRCTN85429598].

  BMC musculoskeletal disorders 20020101

• Morphologic change and elevation of cortisol secretion in cultured human normal adrenocortical cells caused by mutant p21K-ras protein.

  DNA and cell biology 20020101

• Advicor (niacin extended-release and lovastatin tablets).

  Journal of clinical hypertension (Greenwich, Conn.) 20020101

• The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution.

  BMC pharmacology 20020101

• Lovastatin and extended-release niacin combination product: the first drug combination for the management of hyperlipidemia.

  Heart disease (Hagerstown, Md.) 20020101

• Lovastatin is a potent inhibitor of meningioma cell proliferation: evidence for inhibition of a mitogen associated protein kinase.

  Journal of neuro-oncology 20020101

• Statins as modulators of bone formation.

  Arthritis research 20020101

• Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors.

  Clinical pharmacokinetics 20020101

• Basic fibroblast growth factor mediated growth inhibition in breast cancer cells is independent of ras signaling pathway.

  Oncology reports 20020101

• Synergistic interaction between highly specific cyclooxygenase-2 inhibitor, MF-tricyclic and lovastatin in murine colorectal cancer cell lines.

  Oncology reports 20020101

• Food-drug interactions.

  Drugs 20020101

• The role of statins as potential targets for bone formation.

  Arthritis research 20020101

• Insights into integrin-ligand binding and activation from the first crystal structure.

  Arthritis research 20020101

• [Myopathy due to statins, a dose-dependent effect, and of what kind?].

  Atencion primaria 20020101

• Reappraisal of G1-phase arrest and synchronization by lovastatin.

  Cell biology international 20020101

• Oxidation injury in patients receiving HMG-CoA reductase inhibitors: occurrence in patients without enzyme elevation or myopathy.

  Drug safety 20020101

• [Concentration on Diapak C 16 capsules of lovastatin, mevinolinic acid and other inhibitors of biosynthesis of sterins produced by Penicillium citrinum 89].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20020101

• Mevastatin, an inhibitor of HMG-CoA reductase, induces apoptosis, differentiation and Rap1 expression in HL-60 cells.

  Physiological chemistry and physics and medical NMR 20020101

• Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells.

  Clinical & experimental metastasis 20020101

• Interactions between antiretroviral drugs and drugs used for the therapy of the metabolic complications encountered during HIV infection.

  Clinical pharmacokinetics 20020101

• Benefits and menaces related to the use of statins in patients after renal transplantation.

  Annals of transplantation 20020101

• Statins and menopause.

  Drugs 20020101

• Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL.

  Cell cycle (Georgetown, Tex.) 20020101

• A multidisciplinary program for achieving lipid goals in chronic hemodialysis patients.

  BMC nephrology 20020101

• The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells.

  BMC complementary and alternative medicine 20020101

• The discovery and development of atorvastatin, a potent novel hypolipidemic agent.

  Progress in medicinal chemistry 20020101

• Effects of nicotinic acid and lovastatin in combination with cholestyramine in renal transplant patients.

  Missouri medicine 20020101

• Effect of rice--glycerol complex medium on the production of Lovastatin by Monascus ruber.

  Folia microbiologica 20020101

• Effects of policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia associated with type 2 diabetes mellitus.

  International journal of clinical pharmacology research 20020101

• The eye lens evaluation of the atorvastatin-treated white rat.

  Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20020101

• Effects of a tablet-splitting program in patients taking HMG-CoA reductase inhibitors: analysis of clinical effects, patient satisfaction, compliance, and cost avoidance.

  Journal of managed care pharmacy : JMCP 20020101

• Management of protease inhibitor-associated hyperlipidemia.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101

• Application of oxygen vectors to Aspergillus terreus cultivation.

  Journal of bioscience and bioengineering 20020101

• Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins.

  The Journal of biological chemistry 20011214

• Phosphatidylinositol 3-kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene expression by insulin.

  Experimental cell research 20011210

• Diels-Alderases.

  Chembiochem : a European journal of chemical biology 20011203

• Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits.

  Journal of cardiovascular pharmacology 20011201

• Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells.

  The Biochemical journal 20011201

• Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats.

  Clinica chimica acta; international journal of clinical chemistry 20011201

• Are there potential non-lipid-lowering uses of statins in the kidney?

  Nephron 20011201

• Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells.

  Biochemical pharmacology 20011201

• Alpha tocopheryl succinate, retinoic acid and polar carotenoids enhanced the growth-inhibitory effect of a cholesterol-lowering drug on immortalized and transformed nerve cells in culture.

  Journal of the American College of Nutrition 20011201

• Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS): efficacy and tolerability of long-term treatment with lovastatin in women.

  Journal of women's health & gender-based medicine 20011201

• Comparison of endothelial pleiotropic actions of angiotensin converting enzyme inhibitors and statins.

  Annals of the New York Academy of Sciences 20011201

• Synergistic interaction of lovastatin and paclitaxel in human cancer cells.

  Molecular cancer therapeutics 20011201

• [Effects of lovastatin combined with cyclosporine A on cultured human peripheral blood mononuclear cells proliferation, cytokines expression and cytotoxicity].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20011201

• Impairment by lovastatin of neural relaxation of the rabbit sphincter of Oddi.

  European journal of pharmacology 20011130

• Effect of an aggressive lipid-lowering strategy on progression of atherosclerosis in the left main coronary artery from patients in the post coronary artery bypass graft trial.

  Circulation 20011127

• Regulation of hepatic lanosterol 14 alpha-demethylase gene expression by dietary cholesterol and cholesterol-lowering agents.

  Archives of biochemistry and biophysics 20011115

• Comparative squalene synthase gene expression in mouse liver and testis.

  Archives of biochemistry and biophysics 20011115

• CNS synaptogenesis promoted by glia-derived cholesterol.

  Science (New York, N.Y.) 20011109

• Locking a leukocyte integrin with statins.

  The New England journal of medicine 20011108

• Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes.

  FEBS letters 20011102

• Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits.

  Life sciences 20011102

• Lovastatin-induced apoptosis in thyroid cells: involvement of cytochrome c and lamin B.

  European journal of endocrinology 20011101

• Lovastatin increases nitric oxide synthesis in IL-1 beta-stimulated smooth muscle cells.

  Chinese medical journal 20011101

• Inflammatory mechanisms in atherosclerosis: from laboratory evidence to clinical application.

  Italian heart journal : official journal of the Italian Federation of Cardiology 20011101

• [In vitro effect of lovastatin on NB4 promyelocytic leukemia cells].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20011101

• Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis.

  Circulation 20011030

• The antiinflammatory effects of statins.

  The New England journal of medicine 20011018

• The antiinflammatory effects of statins.

  The New England journal of medicine 20011018

• [Can the action of statins reveal etiology of coronary diseases?].

  Lakartidningen 20011017

• Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis.

  Journal of neuroscience research 20011015

• beta-Oxidation of simvastatin in mouse liver preparations.

  Drug metabolism and disposition: the biological fate of chemicals 20011001

• Hyperlipidaemia and cardiovascular disease.

  Current opinion in lipidology 20011001

• Lovastatin-induced E2F-1 modulation and its effect on prostate cancer cell death.

  Carcinogenesis 20011001

• Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases.

  Investigative ophthalmology & visual science 20011001

• The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs.

  Metabolism: clinical and experimental 20011001

• Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells.

  Journal of lipid research 20011001

• Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control study.

  Arteriosclerosis, thrombosis, and vascular biology 20011001

• Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria.

  Plant physiology 20011001

• [Cholesterol, omega-3 fatty acids, and suicide risk: empirical evidence and pathophysiological hypotheses].

  Fortschritte der Neurologie-Psychiatrie 20011001

• Managed care trends in statin usage.

  Managed care (Langhorne, Pa.) 20011001

• Statins in children. Why and when.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20011001

• Safety and efficacy of treatment of children and adolescents with elevated low density lipoprotein levels with a step two diet or with lovastatin.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20011001

• Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner.

  Atherosclerosis 20010901

• CFTR modulates programmed cell death by decreasing intracellular pH in Chinese hamster lung fibroblasts.

  American journal of physiology. Cell physiology 20010901

• Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer.

  Mutation research 20010901

• Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.

  Leukemia 20010901

• Simvastatin-diltiazem drug interaction resulting in rhabdomyolysis and hepatitis.

  Tennessee medicine : journal of the Tennessee Medical Association 20010901

• Effects of lovastatin and pravastatin on cognitive function in military aircrew.

  Aviation, space, and environmental medicine 20010901

• Smoking diminishes the beneficial effect of statins: observations from the landmark trials.

  Angiology 20010901

• C-reactive protein, coronary risk, and statins.

  Harvard women's health watch 20010901

• Oxidation of lovastatin in the solid state and its stabilization with natural antioxidants.

  Die Pharmazie 20010901

• Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.

  Methods and findings in experimental and clinical pharmacology 20010901

• Statins in the 21st century: end of the simple story?

  Expert opinion on investigational drugs 20010901

• In vitro antitumor activity of cerivastatin, a novel and potent HMG-CoA reductase inhibitor.

  FEBS letters 20010817

• Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells.

  International journal of cancer 20010815

• Achieving and maintaining National Cholesterol Education Program low-density lipoprotein cholesterol goals with five statins.

  The American journal of medicine 20010815

• Interaction of cytosine arabinoside and lovastatin in human leukemia cells.

  Leukemia research 20010801

• The widening role of statins: RAS signal transduction and drug-induced cytotoxicity in human leukemia: a commentary to 'interaction of cytosine arabinoside and lovastatin in human leukemia cells'.

  Leukemia research 20010801

• Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis.

  Journal of neurobiology 20010801

• Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens.

  Experimental eye research 20010801

• Correlation of non-high-density lipoprotein cholesterol with apolipoprotein B: effect of 5 hydroxymethylglutaryl coenzyme A reductase inhibitors on non-high-density lipoprotein cholesterol levels.

  The American journal of cardiology 20010801

• Action of an HMG CoA reductase inhibitor, lovastatin, on apoptosis of untransformed and ts-SV40 transformed human smooth muscle cells derived from saphenous vein.

  Journal of cardiovascular pharmacology 20010801

• Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins).

  British journal of pharmacology 20010801

• Possible relationship between statin use and decreased incidence of dementia: are we ready for a new indication for these drugs?

  Archives of internal medicine 20010801

• Pleiotropic effects of statins: do they matter?

  Current opinion in lipidology 20010801

• By the way, doctor... My brother takes Mevacor and has been told to take the drug at bedtime. But when I started on Lipitor, my doctor said to take the medication at any time of the day. Why the difference?

  Harvard health letter 20010801

• Polyketide biosynthesis: a millennium review.

  Natural product reports 20010801

• Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).

  European journal of clinical pharmacology 20010801

• Carboxyl-methylation of Rab3D in the rat pancreatic acinar tumor cell line AR42J.

  Biochemical and biophysical research communications 20010720

• Coronary artery disease progression assessed by electron-beam computed tomography.

  The American journal of cardiology 20010719

• HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2.

  Carcinogenesis 20010701

• Lipophilic statins augment inducible nitric oxide synthase expression in cytokine-stimulated cardiac myocytes.

  Journal of cardiovascular pharmacology 20010701

• Statins and dementia.

  Archives of neurology 20010701

• Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010701

• Essential fatty acids as possible mediators of the actions of statins.

  Prostaglandins, leukotrienes, and essential fatty acids 20010701

• Statin therapy and stroke prevention.

  Current opinion in cardiology 20010701

• The role of cytochrome P450-mediated drug-drug interactions in determining the safety of statins.

  Expert opinion on pharmacotherapy 20010701

• Treatment of the elderly with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors: focus on drug interactions.

  Journal of cardiovascular pharmacology and therapeutics 20010701

• Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives.

  Biochimica et biophysica acta 20010629

• Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events.

  The New England journal of medicine 20010628

• Statins and the acute-phase response.

  The New England journal of medicine 20010628

• The HDV large-delta antigen fused with GFP remains functional and provides for studying its dynamic distribution.

  Virology 20010620

• Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus.

  Bioorganic & medicinal chemistry letters 20010618

• Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors.

  Cancer research 20010615

• Use of statins and the subsequent development of deep vein thrombosis.

  Archives of internal medicine 20010611

• Compactin enhances osteogenesis in murine embryonic stem cells.

  Biochemical and biophysical research communications 20010608

• Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.

  Nature medicine 20010601

• Effect of lovastatin, an HMG CoA reductase inhibitor, on acute renal allograft rejection.

  Clinical transplantation 20010601

• Low-dose combination therapy with colesevelam hydrochloride and lovastatin effectively decreases low-density lipoprotein cholesterol in patients with primary hypercholesterolemia.

  Clinical cardiology 20010601

• Statin therapy and the prevention of dementia.

  Archives of neurology 20010601

• [Improvement of endothelial function in patients with hypercholesterolemia and normal coronary arteries with lipid-lowering therapy].

  Revista espanola de cardiologia 20010601

• Inhibition of growth of methane-producing bacteria of the ruminant forestomach by hydroxymethylglutaryl-SCoA reductase inhibitors.

  Journal of dairy science 20010601

• Plasmodium falciparum: the lethal effects of tunicamycin and mevastatin on the parasite are not mediated by the inhibition of N-linked oligosaccharide biosynthesis.

  Experimental parasitology 20010601

• Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide.

  The international journal of neuropsychopharmacology 20010601

• HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein.

  Pharmaceutical research 20010601

• Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

  Journal of chromatography. A 20010525

• Regulation of sterol regulatory element-binding proteins in hamster intestine by changes in cholesterol flux.

  The Journal of biological chemistry 20010518

• RhoA is activated during respiratory syncytial virus infection.

  Virology 20010510

• Cholesterol ester accumulation: an immediate consequence of acute in vivo ischemic renal injury.

  Kidney international 20010501

• Can modulation of endothelial nitric oxide synthase explain the vasculoprotective actions of statins?

  Trends in molecular medicine 20010501

• Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TEXCAPS): additional perspectives on tolerability of long-term treatment with lovastatin.

  The American journal of cardiology 20010501

• The combined effects of novel tocotrienols and lovastatin on lipid metabolism in chickens.

  Atherosclerosis 20010501

• Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate.

  Clinical pharmacology and therapeutics 20010501

• Long-term administration of the HMG-CoA reductase inhibitor lovastatin in two patients with cholesteryl ester storage disease.

  International journal of clinical pharmacology and therapeutics 20010501

• Should all patients with cardiovascular disease receive statin therapy?

  The American journal of managed care 20010501

• Statins--similarities and differences.

  The American journal of managed care 20010501

• What do the statin trials tell us?

  The American journal of managed care 20010501

• Revised indications for statin therapies.

  Angiology 20010501

• Statin induced myopathy does not show up in MIBI scintigraphy.

  Nuclear medicine communications 20010501

• The National Service Framework on coronary heart disease: is it sufficiently evidence-based?

  Annals of clinical biochemistry 20010501

• Statins and bone formation.

  Current pharmaceutical design 20010501

• Inhibition of purified pig and human liver retinyl ester hydrolase by pharmacologic agents.

  Lipids 20010501

• [Effect of monascus on improving the hemorheology of rats with high blood lipids].

  Wei sheng yan jiu = Journal of hygiene research 20010501

• Methods for synchronizing cells at specific stages of the cell cycle.

  Current protocols in cell biology 20010501

• Deterioration of the protein kinase C-K(ATP) channel pathway in regulation of coronary flow in hypercholesterolaemic rabbits.

  European journal of pharmacology 20010427

• Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.

  Journal of chromatography. B, Biomedical sciences and applications 20010425

• Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice.

  Neuroreport 20010417

• Assessing the results: phase 1 hyperlipidemia outcomes in 27 health plans.

  The American journal of medicine 20010416

• Statins are magic when you gotta have heart.

  U.S. news & world report 20010416

• The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana.

  The Journal of biological chemistry 20010413

• Cell cycle-related changes in regulatory volume decrease and volume-sensitive chloride conductance in mouse fibroblasts.

  Journal of cellular physiology 20010401

• Comparative study of HMG-CoA reductase inhibitors on fibrinogen.

  Atherosclerosis 20010401

• Antiviral activity of lovastatin against respiratory syncytial virus in vivo and in vitro.

  Antimicrobial agents and chemotherapy 20010401

• Rho GTPases are involved in the regulation of NF-kappaB by genotoxic stress.

  Experimental cell research 20010401

• A new simvastatin (mevinolin)-resistance marker from Haloarcula hispanica and a new Haloferax volcanii strain cured of plasmid pHV2.

  Microbiology (Reading, England) 20010401

• Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.

  Stroke 20010401

• The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptor.

  British journal of pharmacology 20010401

• An analysis of nine proprietary Chinese red yeast rice dietary supplements: implications of variability in chemical profile and contents.

  Journal of alternative and complementary medicine (New York, N.Y.) 20010401

• 3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene.

  Insect biochemistry and molecular biology 20010315

• High apolipoprotein B with low high-density lipoprotein cholesterol and normal plasma triglycerides and cholesterol.

  The American journal of cardiology 20010315

• A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro.

  Drug metabolism and disposition: the biological fate of chemicals 20010301

• HMG-CoA reductase inhibitors and P-glycoprotein modulation.

  British journal of pharmacology 20010301

• Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of human farnesyltransferase, BIM-46228.

  International journal of cancer 20010301

• Lovastatin and phenylacetate induce apoptosis, but not differentiation, in human malignant glioma cells.

  Acta neuropathologica 20010301

• Is a statin a statin?

  International journal of clinical practice 20010301

• [Effect of cholesterol deficiency on the membrane fluidity of Jurkat T lymphocytes].

  Wei sheng yan jiu = Journal of hygiene research 20010301

• Lovastatin blocks basic fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition.

  European journal of cell biology 20010301

• [AFCAPS/TexCAPS [The Air Force/Texas Coronary Atherosclerosis Prevention Study]].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• [Statins do not prevent restenosis after coronary angioplasty: where to go from here?].

  Herz 20010301

• Recent advances in the biosynthetic studies of lovastatin.

  Current opinion in drug discovery & development 20010301

• Role of inhibitors of isoprenylation in proliferation, phenotype and apoptosis of human retinal pigment epithelium.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20010301

• A clinical focus on statins.

  Current opinion in investigational drugs (London, England : 2000) 20010301

• [HMG-CoA reductase inhibitors and sexual dysfunction].

  Anales de medicina interna (Madrid, Spain : 1984) 20010301

• Butyrate-induced differentiation of Caco-2 cells occurs independently from p27.

  Biochemical and biophysical research communications 20010223

• Common hepatic lipase gene promoter variant determines clinical response to intensive lipid-lowering treatment.

  Circulation 20010213

• Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation.

  Molecular pharmacology 20010201

• Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease.

  Cardiovascular research 20010201

• Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions.

  The Biochemical journal 20010201

• Bimonthly update. Therapy and clinical trials.

  Current opinion in lipidology 20010201

• Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition.

  Molecular and cellular neurosciences 20010201

• Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effects of cholesterol, sitosterol, and lovastatin.

  Journal of lipid research 20010201

• Do HMG-CoA reductase inhibitors affect fibrinogen?

  The Annals of pharmacotherapy 20010201

• [Statins: a major therapeutic breakthrough].

  Annales d'endocrinologie 20010201

• [Mechanisms of action of statins and their pleiotropic effects].

  Annales d'endocrinologie 20010201

• [Statins and stroke].

  Annales d'endocrinologie 20010201

• [Kidney and statins].

  Annales d'endocrinologie 20010201

• [Statins and diabetic hyperlipidemia].

  Annales d'endocrinologie 20010201

• [Statins: intervention studies, facts and perspectives].

  Annales d'endocrinologie 20010201

• [Practical questions for the expert].

  Annales d'endocrinologie 20010201

• [Endocrine disease in adrenoleukodystrophy].

  Annales de medecine interne 20010201

• Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia.

  Leukemia & lymphoma 20010201

• Metabolites of Monascus ruber in silages.

  Journal of animal physiology and animal nutrition 20010201

• [The role of HDL in the prevention of cardiovascular events].

  Orvosi hetilap 20010121

• [Metabolic interactions with statins].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20010120

• Heart disease. Rethinking treatments for the heart.

  Time 20010115

• Effective use of statins to prevent coronary heart disease.

  American family physician 20010115

• Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

  Gene 20010110

• Apolipoprotein B versus lipoprotein lipids: vital lessons from the AFCAPS/TexCAPS trial.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20010109

• Statin trials in progress: unanswered questions.

  Current atherosclerosis reports 20010101

• New statins and new doses of older statins.

  Current atherosclerosis reports 20010101

• Statins in children: what do we know and what do we need to do?

  Current atherosclerosis reports 20010101

• The benefits of niacin in atherosclerosis.

  Current atherosclerosis reports 20010101

• Reduction of LDL cholesterol in patients with primary hypercholesterolemia by SCH 48461: results of a multicenter dose-ranging study.

  Journal of clinical pharmacology 20010101

• Molecular effects of HMG-CoA reductase inhibitors on smooth muscle cell proliferation.

  Journal of the American College of Cardiology 20010101

• Fragmentation study of simvastatin and lovastatin using electrospray ionization tandem mass spectrometry.

  Journal of mass spectrometry : JMS 20010101

• Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin.

  The Annals of pharmacotherapy 20010101

• Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010101

• A comparative study of policosanol vs lovastatin on intimal thickening in rabbit cuffed carotid artery.

  Pharmacological research 20010101

• Cholesterol-dependent modulation of tau phosphorylation in cultured neurons.

  Journal of neurochemistry 20010101

• The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer.

  Breast cancer research : BCR 20010101

• Cost effectiveness of HMG-CoA reductase inhibition in Canada.

  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20010101

• Phase II study of high-dose lovastatin in patients with advanced gastric adenocarcinoma.

  Investigational new drugs 20010101

• New OTC drugs and devices 2000: a selective review.

  Journal of the American Pharmaceutical Association (Washington,D.C. : 1996) 20010101

• Liver regeneration after hepatectomy.

  Hepato-gastroenterology 20010101

• Lovastatin controls signal transduction in vascular smooth muscle cells by modulating phosphorylation levels of mevalonate-independent pathways.

  Basic research in cardiology 20010101

• Statin-stimulated nitric oxide release from endothelium.

  Medical science monitor : international medical journal of experimental and clinical research 20010101

• Statin therapy.

  Clinical medicine (London, England) 20010101

• Elevated baseline triglyceride levels modulate effects of HMGCoA reductase inhibitors on plasma lipoproteins.

  Journal of cardiovascular pharmacology and therapeutics 20010101

• [Therapeutic and pleiotropic effects of statins in primary and secondary prevention of atherosclerosis].

  Bulletin de l'Academie nationale de medecine 20010101

• Lipid-lowering medications: what the new guidelines and data mean to women.

  The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 20010101

• [Substantiation of increasing doses of statins in clinical practice].

  Terapevticheskii arkhiv 20010101

• [Effects of pathogenetic therapy on blood cholesterol in patients with glomerulonephritis].

  Terapevticheskii arkhiv 20010101

• Transplanted livers and kidneys for HIV+ people.

  TreatmentUpdate 20010101

• Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy.

  Molecular genetics and metabolism 20010101

• Melanoma.

  The oncologist 20010101

• Atorvastatin: an updated review of its pharmacological properties and use in dyslipidaemia.

  Drugs 20010101

• Using test dose challenges to restore essential therapy in patients with idiopathic anaphylaxis and pharmacophobia: report of a patient with idiopathic anaphylaxis and statin phobia.

  Allergy and asthma proceedings 20010101

• Statins as immunomodulatory drugs.

  Advances in experimental medicine and biology 20010101

• Some nutritional factors influencing mevinolin production by Aspergillus terreus strain.

  Folia microbiologica 20010101

• If LDL-C is the answer...what was the question? What do the data really show?

  Heart disease (Hagerstown, Md.) 20010101

• Colesevelam: a new bile acid sequestrant.

  Heart disease (Hagerstown, Md.) 20010101

• Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone.

  The Journal of eukaryotic microbiology 20010101

• Lovastatin inhibits phenylephrine-induced ERK activation and growth of cardiac.

  Cardiovascular toxicology 20010101

• Colesevelam.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

• Increased lipid peroxidation in a patient with CK-elevation and muscle pain during statin therapy.

  Atherosclerosis 20001101

• Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation.

  The Journal of biological chemistry 20001027

• Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii.

  Antimicrobial agents and chemotherapy 20000601

• Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture.

  Atherosclerosis 20000601

• Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells.

  Biochemical and biophysical research communications 20000519

• Lovastatin potentiates antitumor activity and attenuates cardiotoxicity of doxorubicin in three tumor models in mice.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20000501

• Does vitamin E beneficially affect muscle pains during HMG-Co-enzyme-A-reductase inhibitors without CK-elevation?

  Atherosclerosis 20000301

• Lovastatin inhibits G1/S transition of normal human B-lymphocytes independent of apoptosis.

  Experimental cell research 19991010

• Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac.

  Gastroenterology 19991001

• Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 19990801

• Effect of lipid-lowering strategies on tubular cell biology.

  Kidney international. Supplement 19990701

• Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids.

  The Journal of nutrition 19990401

• Two different types of exercise-induced muscle pain without myopathy and CK-elevation during HMG-Co-enzyme-A-reductase inhibitor treatment.

  Atherosclerosis 19990401

• Polymyalgia, hypersensitivity pneumonitis and other reactions in patients receiving HMG-CoA reductase inhibitors: a report of ten cases.

  Chest 19990301

• Lovastatin-induced apoptosis of human medulloblastoma cell lines in vitro.

  Journal of neuro-oncology 19990301

• Statins and peripheral neuropathy.

  European journal of clinical pharmacology 19990101

• Lovastatin inhibits mesangial cell proliferation via p27Kip1.

  Journal of the American Society of Nephrology : JASN 19981201

• The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.

  Cancer research 19981201

• The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

  The Journal of clinical investigation 19980901

• Peripheral neuropathy and lipid-lowering therapy.

  Southern medical journal 19980701

• Insulin-like growth factor-I promotes multidrug resistance in MCLM colon cancer cells.

  Journal of cellular physiology 19980501

• Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19980401

• Aggressive lipid lowering in postcoronary angioplasty patients with elevated cholesterol (the Lovastatin Restenosis Trial).

  The American journal of cardiology 19980301

• Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats.

  Nutrition (Burbank, Los Angeles County, Calif.) 19980301

• Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome.

  Journal of the American Society of Nephrology : JASN 19980201

• Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells.

  Biochimica et biophysica acta 19971030

• (1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.

  Journal of medicinal chemistry 19970704

• Comparison of bezafibrate and simvastatin in the treatment of dyslipidaemia in patients with NIDDM.

  Diabetic medicine : a journal of the British Diabetic Association 19970701

• Rhabdomyolysis, acute renal failure and hepatopathy induced by lovastatin monotherapy.

  Japanese heart journal 19970701

• Rationale and design features of a clinical trial examining the effects of cholesterol lowering and angiotensin-converting enzyme inhibition on coronary atherosclerosis: Simvastatin/Enalapril Coronary Atherosclerosis Trial (SCAT). SCAT Investigators.

  The Canadian journal of cardiology 19970601

• [Myopathy caused by inhibitors of hydroxymethylglutaryl-coenzyme A reductase].

  Revista de neurologia 19970601

• Polymyositis associated with simvastatin.

  Lancet (London, England) 19970531

• Rhabdomyolysis associated with simvastatin-gemfibrozil therapy.

  Southern medical journal 19970501

• Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity.

  Oncogene 19970123

• Myositis and rhabdomyolysis associated with concurrent use of simvastatin and nefazodone.

  JAMA 19970101

• A head-to-head comparison of the cost effectiveness of HMG-CoA reductase inhibitors and fibrates in different types of primary hyperlipidemia.

  Cardiovascular drugs and therapy 19970101

• Simvastatin-induced myopathy in a patient treated for hypercholesterolemia. Morphological aspects.

  Polish journal of pathology : official journal of the Polish Society of Pathologists 19970101

• Human multidrug-resistant (MRP,p190) myeloid leukemia HL-60/ADR cells in vitro: resistance to the mevalonate pathway inhibitor lovastatin.

  Neoplasma 19970101

• Acute on chronic renal failure induced by simvastatin.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19961101

• Lovastatin-associated dermatomyositis.

  Postgraduate medical journal 19961101

• [Hepatitis due to lovastatin].

  Medicina clinica 19961026

• Myoglobinuric renal failure due to long-standing lovastatin therapy in a patient with pre-existing chronic renal insufficiency.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19961001

• Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells.

  Biochimica et biophysica acta 19960412

• HMG-CoA reductase inhibitor-induced impotence.

  The Annals of pharmacotherapy 19960201

• Fluvastatin in combination with other lipid-lowering agents.

  British journal of clinical practice. Supplement 19960101

• [Terminal myoglobinuric renal failure in lovastatin therapy with pre-existing chronic renal insufficiency].

  Wiener klinische Wochenschrift 19960101

• Lovastatin and peripheral neuropathy.

  American heart journal 19951201

• Enalapril and peripheral neuropathy.

  Journal of the American Geriatrics Society 19951001

• Currently available hypolipidaemic drugs and future therapeutic developments.

  Bailliere's clinical endocrinology and metabolism 19951001

• Lovastatin-induced myopathy in a hypothyroid patient.

  The Journal of family practice 19950901

• Lovastatin-induced hemolytic anemia: not a class-specific reaction.

  The American journal of medicine 19950901

• Depression-induced absenteeism in relation to antihyperlipidemic treatment: a study using GAZEL cohort data.

  Epidemiology (Cambridge, Mass.) 19950501

• Peripheral neuropathy associated with simvastatin.

  Journal of neurology, neurosurgery, and psychiatry 19950501

• [Lovastatin-induced acute cholestatic hepatitis].

  Deutsche medizinische Wochenschrift (1946) 19950224

• In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin.

  Cancer research 19950201

• Fluvastatin in combination with other lipid-lowering agents.

  British journal of clinical practice. Supplement 19941201

• Expanded Clinical Evaluation of Lovastatin (EXCEL) study results: two-year efficacy and safety follow-up.

  The American journal of cardiology 19941001

• Synthesis and biological activity of bile acid-derived HMG-CoA reductase inhibitors. The role of 21-methyl in recognition of HMG-CoA reductase and the ileal bile acid transport system.

  Journal of medicinal chemistry 19940930

• Cytotoxicity of simvastatin to pancreatic adenocarcinoma cells containing mutant ras gene.

  Japanese journal of cancer research : Gann 19940601

• HMG-CoA reductase inhibitor therapy and peripheral neuropathy.

  Annals of internal medicine 19940601

• Sleep disturbance and appetite loss after lovastatin.

  Lancet (London, England) 19940416

• Isoprenoid biosynthesis in rat liver mitochondria. Studies on farnesyl pyrophosphate synthase and trans-prenyltransferase.

  The Journal of biological chemistry 19940225

• Simvastatin-associated dermatomyositis.

  British journal of rheumatology 19940201

• [Porphyria cutanea tarda induced by HMG CoA reductase inhibitors: simvastatin, pravastatin].

  Annales de dermatologie et de venereologie 19940101

• Effect of simvastatin treatment on plasma apolipoproteins and hepatic apolipoprotein mRNA levels in the genetically hypercholesterolemic rat (RICO).

  Life sciences 19940101

• Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors.

  Journal of medicinal chemistry 19931112

• Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.

  Journal of medicinal chemistry 19931112

• HMG-CoA reductase inhibitors: design, synthesis, and biological activity of tetrahydroindazole-substituted 3,5-dihydroxy-6-heptenoic acid sodium salts.

  Journal of medicinal chemistry 19931112

• Unrecognized adverse drug reactions.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 19931101

• Lovastatin-associated sleep and mood disturbances.

  The American journal of medicine 19931101

• Simvastatin inhibits PDGF-induced DNA synthesis in human glomerular mesangial cells.

  Kidney international 19930901

• Rhabdomyolysis and renal failure secondary to combination therapy of hyperlipidemia with lovastatin and gemfibozil.

  Connecticut medicine 19930901

• Experimental lovastatin myopathy.

  Journal of neuropathology and experimental neurology 19930901

• Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.

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  Nederlands tijdschrift voor geneeskunde 19930626

• Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase.

  Biochemical pharmacology 19930609

• Efficacy and tolerability of lovastatin in 3390 women with moderate hypercholesterolemia.

  Annals of internal medicine 19930601

• Lovastatin 5-year safety and efficacy study. Lovastatin Study Groups I through IV.

  Archives of internal medicine 19930510

• The effect of the HMG-CoA reductase inhibitor simvastatin and of cholestyramine on hepatic apolipoprotein mRNA levels in the rat.

  Biochimica et biophysica acta 19930317

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• Depressive symptoms and cholesterol-lowering drugs.

  Lancet (London, England) 19930109

• Influence of specific mutations at the LDL-receptor gene locus on the response to simvastatin therapy in Afrikaner patients with heterozygous familial hypercholesterolaemia.

  Atherosclerosis 19930104

• Effects of anti-hyperlipidaemic agent or dietary protein restriction on progressive renal deterioration in adriamycin-induced nephropathy in rats.

  International urology and nephrology 19930101

• RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent.

  Pharmacology 19930101

• 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs.

  Journal of medicinal chemistry 19921016

• Synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

  Journal of medicinal chemistry 19920904

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  Laryngo- rhino- otologie 19920901

• Possible mechanism and treatment of o,p'DDD-induced hypercholesterolaemia.

  The Quarterly journal of medicine 19920901

• Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.

  Biochimica et biophysica acta 19920709

• Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias.

  The American journal of cardiology 19920701

• Myopathy associated with HMG-CoA reductase inhibitors (HMGRIs) and cyclosporin A: evaluation in a rat model.

  European heart journal 19920701

• Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted- pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones.

  Journal of medicinal chemistry 19920529

• Lovastatin-induced hepatitis.

  Israel journal of medical sciences 19920201

• Transcriptional derepression of the murine Cyp1a-1 gene by mevinolin.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19920106

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  Minerva gastroenterologica e dietologica 19920101

• Lovastatin/gemfibrozil myopathy: a clinical, histochemical, and ultrastructural study.

  European neurology 19920101

• Lack of hypotension with lovastatin and pravastatin.

  Lancet (London, England) 19911123

• Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.

  Journal of medicinal chemistry 19911001

• Gemfibrozil-induced myopathy.

  Archives of internal medicine 19910901

• Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety.

  Journal of medicinal chemistry 19910901

• 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivatives.

  Journal of medicinal chemistry 19910801

• Cholesterol-lowering agent myopathy (CLAM).

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• HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies.

  The Journal of pharmacology and experimental therapeutics 19910601

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  Lancet (London, England) 19910406

• Acute cholestatic hepatitis during simvastatin administration.

  Recenti progressi in medicina 19910401

• Expanded Clinical Evaluation of Lovastatin (EXCEL) study results. I. Efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia.

  Archives of internal medicine 19910101

• Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors.

  Journal of medicinal chemistry 19910101

• Rhabdomyolysis with simvastatin use.

  Nephron 19910101

• Proteinuria as complication of simvastatin treatment.

  Lancet (London, England) 19901208

• Rhabdomyolysis secondary to lovastatin therapy.

  Clinical chemistry 19901201

• Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

  Journal of medicinal chemistry 19901101

• Lovastatin decreases coenzyme Q levels in humans.

  Proceedings of the National Academy of Sciences of the United States of America 19901101

• Inhibitors of hydroxymethylglutaryl coenzyme A reductase for treating hypercholesterolaemia.

  BMJ (Clinical research ed.) 19900929

• Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy.

  JAMA 19900704

• Cholestatic jaundice associated with lovastatin (Mevacor) therapy.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 19900415

• Purification and regulation of mevalonate kinase from rat liver.

  The Journal of biological chemistry 19900205

• Rhabdomyolysis and acute renal failure induced by combination lovastatin and gemfibrozil therapy.

  Annals of internal medicine 19900201

• Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.

  Journal of medicinal chemistry 19900101

• Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles.

  Journal of medicinal chemistry 19900101

• Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids.

  Journal of medicinal chemistry 19900101

• Lovastatin, isoprenes, and myopathy.

  Lancet (London, England) 19891104

• Plasma mevalonate response in lovastatin-related myopathy.

  Lancet (London, England) 19891104

• Transient symptomatic hypotension in patients on simvastatin.

  Lancet (London, England) 19890930

• Treatment of heterozygous familial hypercholesterolemia with lipid-lowering drugs.

  Arteriosclerosis (Dallas, Tex.) 19890101

• Efficacy and long-term adverse effect pattern of lovastatin.

  The American journal of cardiology 19881111

• Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients.

  JAMA 19880708

• Myolysis and acute renal failure in a heart-transplant recipient receiving lovastatin.

  The New England journal of medicine 19880107

• HMG CoA reductase inhibitors. Current clinical experience.

  Drugs 19880101

• Total synthesis and biological evaluation of structural analogues of compactin and dihydromevinolin.

  Journal of medicinal chemistry 19871001

• 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin.

  Journal of medicinal chemistry 19860501

• Activation of rat liver microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase by NADPH. Effects of dietary treatments.

  The Journal of biological chemistry 19851015

• Sources of extramitochondrial corticoidogenic cholesterol in the adrenal cortex.

  Japanese journal of pharmacology 19850601

• Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase.

  Journal of medicinal chemistry 19850401

• Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

  Proceedings of the National Academy of Sciences of the United States of America 19800701

• Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity.

  FEBS letters 19761231