766-55-2 | Imidazo[1,2-b]pyridazine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$8.00	$6.00
5g	95%	in stock	$10.00	$7.00
25g	95%	in stock	$28.00	$19.00
100g	95%	in stock	$108.00	$76.00

Description

• Catalog Number: AB74746
• Chemical Name: Imidazo[1,2-b]pyridazine
• CAS Number: 766-55-2
• Molecular Formula: C6H5N3
• Molecular Weight: 119.1240
• MDL Number: MFCD07782103
• SMILES: c1cnn2c(c1)ncc2

Computed Properties

• Complexity: 105
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 0.3

Literature

• Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.

  Journal of medicinal chemistry 20120412

• Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: exploration of effective compounds in arthritis models.

  Bioorganic & medicinal chemistry letters 20110801

• Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.

  Blood 20110721

• Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism.

  Biochemistry 20110208

• Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: improvement of potency in vitro and in vivo.

  Bioorganic & medicinal chemistry letters 20110201

• Urocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference.

  PloS one 20110101

• Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship.

  Bioorganic & medicinal chemistry letters 20100901

• Inhibitors of PIM-1 kinase: a computational analysis of the binding free energies of a range of imidazo [1,2-b] pyridazines.

  Journal of chemical information and modeling 20100322

• Intra-periaqueductal grey microinjections of an imidazo[1,2-b]pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect.

  Neuropharmacology 20100301

• Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.

  Blood 20091105

• Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.

  Structure (London, England : 1993) 20090311

• T-type channel blocking properties and antiabsence activity of two imidazo[1,2-b]pyridazine derivatives structurally related to indomethacin.

  Neuropharmacology 20090301

• Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20040503