7782-92-5 | Sodium amide (Na(NH2))

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Description

• Catalog Number: AI66070
• Chemical Name: Sodium amide (Na(NH2))
• CAS Number: 7782-92-5
• Molecular Formula: H2NNa
• Molecular Weight: 39.0123
• MDL Number: MFCD00011117
• SMILES: N[Na]

Upstream Synthesis Route

Sodium amide is a versatile and powerful reagent commonly used in chemical synthesis, particularly in organic chemistry. It serves as a strong base due to its ability to deprotonate even very weak acids. This property makes sodium amide a valuable tool in various reactions where a strong base is required to initiate or facilitate a chemical transformation.One key application of sodium amide is in the synthesis of alkyne compounds through deprotonation of terminal alkynes. By utilizing sodium amide as a base, reactions can be driven towards the formation of alkynes, enabling the synthesis of a wide range of organic molecules with unique properties and functions.Additionally, sodium amide is commonly employed in the preparation of carbonyl compounds by reaction with ketones or aldehydes. This reaction, known as the Stieglitz rearrangement, is a powerful synthetic tool for generating important functional groups in organic molecules.Furthermore, sodium amide is utilized in the synthesis of various nitrogen-containing compounds, such as azides and hydrazines. Its strong basicity allows for efficient N-alkylation reactions, providing chemists with a valuable method for the introduction of nitrogen-containing groups into organic structures.Overall, the diverse applications of sodium amide in chemical synthesis highlight its significance as a crucial reagent for the construction of complex organic molecules and the development of novel chemical pathways.