78-98-8 | 2-oxopropanal, 40% in water

Packsize	Purity	Availability	Price	Discounted Price
25g	~40% in H2O	in stock	$7.00	$5.00
100g	~40% in H2O	in stock	$21.00	$15.00

Description

• Catalog Number: AB46970
• Chemical Name: 2-oxopropanal, 40% in water
• CAS Number: 78-98-8
• Molecular Formula: C3H4O2
• Molecular Weight: 72.0627
• MDL Number: MFCD00006960
• SMILES: O=CC(=O)C

Computed Properties

• Complexity: 55.9
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 5
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• XLogP3: -0.4

Literature

• Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury.

  Toxicology letters 20180915

• Limonene protects osteoblasts against methylglyoxal-derived adduct formation by regulating glyoxalase, oxidative stress, and mitochondrial function.

  Chemico-biological interactions 20171225

• Magnolol protects pancreatic β-cells against methylglyoxal-induced cellular dysfunction.

  Chemico-biological interactions 20171101

• Hepatoprotective effect of 7-Hydroxycoumarin against Methyl glyoxal toxicity via activation of Nrf2.

  Chemico-biological interactions 20171001

• Reactive carbonyl compounds impair wound healing by vimentin collapse and loss of the primary cilium.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001

• Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy.

  Reproductive toxicology (Elmsford, N.Y.) 20160701

• Non-enzymatic modifications of prostaglandin H synthase 1 affect bifunctional enzyme activity - Implications for the sensitivity of blood platelets to acetylsalicylic acid.

  Chemico-biological interactions 20160625

• Protective effects of honokiol against methylglyoxal-induced osteoblast damage.

  Chemico-biological interactions 20160125

• Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells.

  Chemico-biological interactions 20151205

• Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity.

  Chemical research in toxicology 20150615

• Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2.

  Chemico-biological interactions 20150605

• Inhibitory effect of apocynin on methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells.

  Journal of applied toxicology : JAT 20150401

• Fatty acids binding to human serum albumin: Changes of reactivity and glycation level of Cysteine-34 free thiol group with methylglyoxal.

  Chemico-biological interactions 20141205

• Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status.

  Journal of bioenergetics and biomembranes 20141001

• Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20140601

• Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?

  Toxins 20140101

• A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia.

  Toxicology and applied pharmacology 20131101

• Resveratrol protects against methylglyoxal-induced apoptosis and disruption of embryonic development in mouse blastocysts.

  Environmental toxicology 20130801

• Glyoxal and methylglyoxal: autoxidation from dihydroxyacetone and polyphenol cytoprotective antioxidant mechanisms.

  Chemico-biological interactions 20130225

• Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats.

  Journal of agricultural and food chemistry 20130213

• A nonradioisotope chemiluminescent assay for evaluation of 2-deoxyglucose uptake in 3T3-L1 adipocytes. Effect of various carbonyls species on insulin action.

  Biochimie 20121201

• Effect of high hydrostatic pressure on antimicrobial activity and quality of Manuka honey.

  Food chemistry 20121201

• Voltammetric detection of the α-dicarbonyl compound: methylglyoxal as a flavoring agent in wine and beer.

  Analytica chimica acta 20121102

• Exogenous selenium pretreatment protects rapeseed seedlings from cadmium-induced oxidative stress by upregulating antioxidant defense and methylglyoxal detoxification systems.

  Biological trace element research 20121101

• Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism.

  Journal of neurochemistry 20121101

• Antioxidant content and activity of the Indian fresh-water pearl mussel in the prevention of arthritis in an experimental animal model.

  The British journal of nutrition 20121028

• Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging.

  The Journal of dermatological treatment 20121001

• Catalase, a target of glycation damage in rat liver mitochondria with aging.

  Biochimica et biophysica acta 20121001

• Carbonyl stress and a combination of astaxanthin/vitamin C induce biochemical changes in human neutrophils.

  Toxicology in vitro : an international journal published in association with BIBRA 20121001

• Targeting the glyoxalase pathway enhances TRAIL efficacy in cancer cells by downregulating the expression of antiapoptotic molecules.

  Molecular cancer therapeutics 20121001

• Whole globe inflation testing of exogenously crosslinked sclera using genipin and methylglyoxal.

  Experimental eye research 20121001

• Development of a method for the determination of advanced glycation end products precursors by liquid chromatography and its application in human urine samples.

  Journal of separation science 20121001

• The glyoxalase pathway in protozoan parasites.

  International journal of medical microbiology : IJMM 20121001

• An initial investigation into the anti-inflammatory activity and antioxidant capacity of alpha-cyclodextrin-complexed Manuka honey.

  Journal of complementary & integrative medicine 20120924

• Resveratrol upregulates Nrf2 expression to attenuate methylglyoxal-induced insulin resistance in Hep G2 cells.

  Journal of agricultural and food chemistry 20120912

• Impaired drug-binding capacities of in vitro and in vivo glycated albumin.

  Biochimie 20120901

• Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus.

  Molecular pharmacology 20120901

• The role of endothelial cell adhesion molecules P-selectin, E-selectin and intercellular adhesion molecule-1 in leucocyte recruitment induced by exogenous methylglyoxal.

  Immunology 20120901

• Anti-glycative and anti-inflammatory effects of protocatechuic acid in brain of mice treated by D-galactose.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• Trapping of methylglyoxal by curcumin in cell-free systems and in human umbilical vein endothelial cells.

  Journal of agricultural and food chemistry 20120822

• Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal.

  Brain research 20120821

• Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies.

  The Journal of biological chemistry 20120817

• Anti-oxidative, anti-glycative and anti-apoptotic effects of oleanolic acid in brain of mice treated by D-galactose.

  European journal of pharmacology 20120815

• Dual effect of methylglyoxal on the intracellular Ca2+ signaling and neurite outgrowth in mouse sensory neurons.

  Cellular and molecular neurobiology 20120801

• Decarboxylation mechanisms in biological system.

  Bioorganic chemistry 20120801

• Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade.

  International journal of oncology 20120801

• Methylglyoxal inhibition of cytosolic ascorbate peroxidase from Nicotiana tabacum.

  Journal of biochemical and molecular toxicology 20120801

• Glycation and insulin resistance: novel mechanisms and unique targets?

  Arteriosclerosis, thrombosis, and vascular biology 20120801

• Reactive carbonyl compounds (RCCs) cause aggregation and dysfunction of fibrinogen.

  Protein & cell 20120801

• Glyoxalase I (GLO1) is up-regulated in pancreatic cancerous tissues compared with related non-cancerous tissues.

  Anticancer research 20120801

• [The biological reaction of inflammation, methylglyoxal of blood plasma, functional and structural alterations in elastic type arteries at the early stage of hypertension disease].

  Klinicheskaia laboratornaia diagnostika 20120801

• Classification and characterization of manuka honeys based on phenolic compounds and methylglyoxal.

  Journal of agricultural and food chemistry 20120725

• Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes.

  Circulation research 20120720

• 1,2-dicarbonyl compounds in commonly consumed foods.

  Journal of agricultural and food chemistry 20120718

• Human DJ-1 and its homologs are novel glyoxalases.

  Human molecular genetics 20120715

• Aristolochic acid-induced accumulation of methylglyoxal and Nε-(carboxymethyl)lysine: an important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy.

  Biochemical and biophysical research communications 20120713

• N-acetylcysteine reduces oxidative stress in sickle cell patients.

  Annals of hematology 20120701

• Identification and quantification of six major α-dicarbonyl process contaminants in high-fructose corn syrup.

  Analytical and bioanalytical chemistry 20120701

• Methylglyoxal-induced stomatal closure accompanied by peroxidase-mediated ROS production in Arabidopsis.

  Journal of plant physiology 20120701

• Ambiguous effect of dendrimer PAMAM G3 on rat heart respiration in a model of an experimental diabetes - Objective causes of laboratory misfortune or unpredictable G3 activity?

  International journal of pharmaceutics 20120701

• Arginine attenuates methylglyoxal- and high glucose-induced endothelial dysfunction and oxidative stress by an endothelial nitric-oxide synthase-independent mechanism.

  The Journal of pharmacology and experimental therapeutics 20120701

• A quick, convenient and economical method for the reliable determination of methylglyoxal in millimolar concentrations: the N-acetyl-L-cysteine assay.

  Analytical and bioanalytical chemistry 20120701

• Tight-binding inhibitors efficiently inactivate both reaction centers of monomeric Plasmodium falciparum glyoxalase 1.

  The FEBS journal 20120701

• Stereospecificity of (1) H, (13) C and (15) N shielding constants in the isomers of methylglyoxal bisdimethylhydrazone: problem with configurational assignment based on (1) H chemical shifts.

  Magnetic resonance in chemistry : MRC 20120701

• Degradation of bacterial DNA by a natural antimicrobial agent with the help of biomimetic membrane system.

  Indian journal of experimental biology 20120701

• Unusually fast 1,6-h shifts of enolic hydrogens in peroxy radicals: formation of the first-generation C2 and C3 carbonyls in the oxidation of isoprene.

  The journal of physical chemistry. A 20120621

• Investigation of aqueous-phase photooxidation of glyoxal and methylglyoxal by aerosol chemical ionization mass spectrometry: observation of hydroxyhydroperoxide formation.

  The journal of physical chemistry. A 20120621

• Laboratory kinetic and mechanistic studies on the OH-initiated oxidation of acetone in aqueous solution.

  The journal of physical chemistry. A 20120621

• Diabetes: Methylglyoxal mediates hyperalgesia in patients with painful diabetic neuropathy.

  Nature reviews. Neurology 20120612

• Flavour chemistry of methylglyoxal and glyoxal.

  Chemical Society reviews 20120607

• Reaction of methacrolein with the hydroxyl radical in air: incorporation of secondary O2 addition into the MACR + OH master equation.

  The journal of physical chemistry. A 20120607

• A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy.

  Amino acids 20120601

• Exogenous collagen cross-linking recovers tendon functional integrity in an experimental model of partial tear.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20120601

• Methylglyoxal-induced modifications of significant honeybee proteinous components in manuka honey: Possible therapeutic implications.

  Fitoterapia 20120601

• Varying amounts of different aldehydes present in the cryoprotectants dimethyl sulphoxide and 1,2-propanediol.

  Cryobiology 20120601

• Mycobacterium tuberculosis Rv0577, a novel TLR2 agonist, induces maturation of dendritic cells and drives Th1 immune response.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120601

• Mitochondrial involvement to methylglyoxal detoxification: D-Lactate/Malate antiporter in Saccharomyces cerevisiae.

  Antonie van Leeuwenhoek 20120601

• Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease.

  Clinical journal of the American Society of Nephrology : CJASN 20120601

• Dke1--structure, dynamics, and function: a theoretical and experimental study elucidating the role of the binding site shape and the hydrogen-bonding network in catalysis.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20120601

• Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.

  Nature medicine 20120601

• Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal.

  The Journal of clinical investigation 20120601

• Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline.

  Frontiers in bioscience (Elite edition) 20120601

• Exploring post-translational arginine modification using chemically synthesized methylglyoxal hydroimidazolones.

  Journal of the American Chemical Society 20120530

• Rapid and sensitive determination of the intermediates of advanced glycation end products in the human nail by ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry.

  Analytical biochemistry 20120515

• Impact of the N-terminal amino acid on the formation of pyrazines from peptides in Maillard model systems.

  Journal of agricultural and food chemistry 20120509

• Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains.

  Psychopharmacology 20120501

• Gliclazide may have an antiapoptotic effect related to its antioxidant properties in human normal and cancer cells.

  Molecular biology reports 20120501

• Methylglyoxal induces hyperpermeability of the blood-retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20120501

• Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity.

  Archives of physiology and biochemistry 20120501

• Methylglyoxal promotes oxidative stress and endothelial dysfunction.

  Pharmacological research 20120501

• The missing link in coenzyme A biosynthesis: PanM (formerly YhhK), a yeast GCN5 acetyltransferase homologue triggers aspartate decarboxylase (PanD) maturation in Salmonella enterica.

  Molecular microbiology 20120501

• Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia.

  Molecular microbiology 20120501

• Optical properties of the products of α-dicarbonyl and amine reactions in simulated cloud droplets.

  Environmental science & technology 20120501

• Short communication: Evidence for methylglyoxal-mediated browning of Parmesan cheese during low temperature storage.

  Journal of dairy science 20120501

• Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT.

  PLoS computational biology 20120501

• Study on the changes of carbonic anhydrase activity in insulin resistance and the effect of methylglyoxal.

  JPMA. The Journal of the Pakistan Medical Association 20120501

• Chromatographic determination of methyl glyoxal in blood plasma as the test for glycotoxicity and accumulation of glycation end-products.

  Bulletin of experimental biology and medicine 20120501

• Discovering protein-based inheritance through yeast genetics.

  The Journal of biological chemistry 20120427

• Inhibition of advanced glycation end product formation by Pu-erh tea ameliorates progression of experimental diabetic nephropathy.

  Journal of agricultural and food chemistry 20120425

• [The role of methylglyoxal metabolism in type-2 diabetes and its complications].

  Orvosi hetilap 20120415

• Cavity closure dynamics of peracetylated β-cyclodextrins in supercritical carbon dioxide.

  The journal of physical chemistry. B 20120405

• Advanced glycation endproducts and their pathogenic roles in neurological disorders.

  Amino acids 20120401

• Advanced glycation endproducts: from precursors to RAGE: round and round we go.

  Amino acids 20120401

• Lipid glycation and protein glycation in diabetes and atherosclerosis.

  Amino acids 20120401

• Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics.

  Amino acids 20120401

• Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome.

  Amino acids 20120401

• Theoretical studies on models of lysine-arginine cross-links derived from α-oxoaldehydes: a new mechanism for glucosepane formation.

  Journal of molecular modeling 20120401

• Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in parkinsonian brains.

  Journal of neural transmission (Vienna, Austria : 1996) 20120401

• Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.

  The Biochemical journal 20120401

• Two alanine aminotranferases link mitochondrial glycolate oxidation to the major photorespiratory pathway in Arabidopsis and rice.

  Journal of experimental botany 20120401

• Physiological and proteomic approaches to address the active role of ozone in kiwifruit post-harvest ripening.

  Journal of experimental botany 20120401

• Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?

  Diabetologia 20120401

• Methylglyoxal, advanced glycation end products and autism: is there a connection?

  Medical hypotheses 20120401

• Structural modifications of human albumin in diabetes.

  Diabetes & metabolism 20120401

• Glutathione peroxidase inhibitory assay for electrophilic pollutants in diesel exhaust and tobacco smoke.

  Analytical and bioanalytical chemistry 20120401

• Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20120401

• Nephrotoxin-induced renal cell injury involving biochemical alterations and its prevention with antioxidant.

  Journal of clinical medicine research 20120401

• Postprandial impairment of flow-mediated dilation and elevated methylglyoxal after simple but not complex carbohydrate consumption in dogs.

  Nutrition research (New York, N.Y.) 20120401

• Comparative DFT study to determine if α-oxoaldehydes are precursors for pentosidine formation.

  The journal of physical chemistry. A 20120322

• A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.

  The EMBO journal 20120321

• Potential of a γ-glutamyl-transpeptidase-stable glutathione analogue against amyloid-β toxicity.

  ACS chemical neuroscience 20120321

• Cathepsins D and L reduce the toxicity of advanced glycation end products.

  Free radical biology & medicine 20120315

• γ-Tocopherol abolishes postprandial increases in plasma methylglyoxal following an oral dose of glucose in healthy, college-aged men.

  The Journal of nutritional biochemistry 20120301

• A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP.

  Journal of neural transmission (Vienna, Austria : 1996) 20120301

• Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology.

  Diabetologia 20120301

• Ni2+-activated glyoxalase I from Escherichia coli: substrate specificity, kinetic isotope effects and evolution within the βαβββ superfamily.

  Journal of inorganic biochemistry 20120301

• Protection from diabetes-induced peripheral sensory neuropathy--a role for elevated glyoxalase I?

  Experimental neurology 20120301

• Use of denuder/filter apparatus to investigate terpene ozonolysis.

  Journal of environmental monitoring : JEM 20120301

• Different response of body weight change according to ketonuria after fasting in the healthy obese.

  Journal of Korean medical science 20120301

• New Zealand kanuka honey has high levels of methylglyoxal and antimicrobial activity.

  Journal of alternative and complementary medicine (New York, N.Y.) 20120301

• Oxidative modification of ferritin induced by methylglyoxal.

  BMB reports 20120301

• Opportunistic parasites among immunosuppressed children in Minia District, Egypt.

  The Korean journal of parasitology 20120301

• Accumulation of argpyrimidine, a methylglyoxal-derived advanced glycation end product, increases apoptosis of lens epithelial cells both in vitro and in vivo.

  Experimental & molecular medicine 20120227

• The overall reaction process of ozone with methacrolein and isoprene in the condensed phase.

  The journal of physical chemistry. A 20120223

• Organocatalytic enantioselective synthesis of 2,3-dihydropyridazines.

  Chemical communications (Cambridge, England) 20120218

• Ellagic acid, a new antiglycating agent: its inhibition of Nϵ-(carboxymethyl)lysine.

  The Biochemical journal 20120215

• Phlorotannins from brown algae (Fucus vesiculosus) inhibited the formation of advanced glycation endproducts by scavenging reactive carbonyls.

  Journal of agricultural and food chemistry 20120208

• Photoexcited tautomerization of vinyl alcohol to acetylaldehyde via a conical intersection from contracted Schrödinger theory.

  Physical chemistry chemical physics : PCCP 20120207

• Effect of coffee filtrate, methylglyoxal, glyoxal, and caffeine on Salmonella typhimurium and S. enteritidis survival in ground chicken breasts.

  Journal of food science 20120201

• pPKCα mediated-HIF-1α activation related to the morphological modifications occurring in neonatal myocardial tissue in response to severe and mild hyperoxia.

  European journal of histochemistry : EJH 20120120

• Formation of early and advanced Maillard reaction products correlates to the ripening of cheese.

  Journal of agricultural and food chemistry 20120118

• Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose.

  Experimental cell research 20120115

• Human aldo-keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells.

  Chemico-biological interactions 20120105

• Epigallocatechin gallate suppresses peritoneal fibrosis in mice.

  Chemico-biological interactions 20120105

• Reduction of glucose uptake through inhibition of hexose transporters and enhancement of their endocytosis by methylglyoxal in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20120102

• 'NEPP' peritoneal dialysis regimen has beneficial effects on plasma CEL and 3-DG, but not pentosidine, CML, and MGO.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20120101

• High levels of IgM against methylglyoxal-modified apolipoprotein B100 are associated with less coronary artery calcification in patients with type 2 diabetes.

  Journal of internal medicine 20120101

• Beneficial effect of traditional chinese medicinal formula danggui-shaoyao-san on advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Long-term methylglyoxal treatment impairs smooth muscle contractility in organ-cultured rat mesenteric artery.

  Pharmacological research 20120101

• Antioxidant and anti-inflammatory effects of exercise in diabetic patients.

  Experimental diabetes research 20120101

• Antibacterial components of honey.

  IUBMB life 20120101

• Cloning and characterization of AKR4C14, a rice aldo-keto reductase, from Thai Jasmine rice.

  The protein journal 20120101

• Regulation of RAGE for attenuating progression of diabetic vascular complications.

  Experimental diabetes research 20120101

• Leukocyte adhesion molecules in diabetic retinopathy.

  Journal of ophthalmology 20120101

• Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy.

  Pharmacological research 20120101

• Chemical and physiological relevance of glucose degradation products in peritoneal dialysis.

  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20120101

• Engineered Trx2p industrial yeast strain protects glycolysis and fermentation proteins from oxidative carbonylation during biomass propagation.

  Microbial cell factories 20120101

• Lignin is linked to ethyl-carbamate formation in ume (Prunus mume) liqueur.

  Bioscience, biotechnology, and biochemistry 20120101

• Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress.

  Experimental diabetes research 20120101

• Long-term survival of hydrated resting eggs from Brachionus plicatilis.

  PloS one 20120101

• Hydroimidazolone modification of the conserved Arg12 in small heat shock proteins: studies on the structure and chaperone function using mutant mimics.

  PloS one 20120101

• Environmental factors affecting the expression of pilAB as well as the proteome and transcriptome of the grass endophyte Azoarcus sp. strain BH72.

  PloS one 20120101

• The role of methylglyoxal-modified proteins in gastric ulcer healing.

  Current medicinal chemistry 20120101

• Astroglial pentose phosphate pathway rates in response to high-glucose environments.

  ASN neuro 20120101

• Markov Chain Ontology Analysis (MCOA).

  BMC bioinformatics 20120101

• Role of the HaHOG1 MAP kinase in response of the conifer root and butt rot pathogen (heterobasidion annosum) to osmotic and oxidative stress [corrected].

  PloS one 20120101

• Hydroxyl radical modification of collagen type II increases its arthritogenicity and immunogenicity.

  PloS one 20120101

• Exploring mechanisms of diabetes-related macrovascular complications: role of methylglyoxal, a metabolite of glucose on regulation of vascular contractility.

  Journal of pharmacological sciences 20120101

• Long term running biphasically improves methylglyoxal-related metabolism, redox homeostasis and neurotrophic support within adult mouse brain cortex.

  PloS one 20120101

• Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats.

  Molecular vision 20120101

• Transcriptome analyses of a salt-tolerant cytokinin-deficient mutant reveal differential regulation of salt stress response by cytokinin deficiency.

  PloS one 20120101

• Protein carbonylation and aggregation precede neuronal apoptosis induced by partial glutathione depletion.

  ASN neuro 20120101

• 17β-Estradiol is required for the sexually dimorphic effects of repeated binge-pattern alcohol exposure on the HPA axis during adolescence.

  PloS one 20120101

• Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization.

  PloS one 20120101

• Optimization of time-course experiments for kinetic model discrimination.

  PloS one 20120101

• Amyloid-β metabolite sensing: biochemical linking of glycation modification and misfolding.

  Journal of Alzheimer's disease : JAD 20120101

• Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells.

  Chemistry Central journal 20120101

• Inhibitory effects of methylglyoxal on light-induced stomatal opening and inward K+ channel activity in Arabidopsis.

  Bioscience, biotechnology, and biochemistry 20120101

• Role of forkhead transcription factors in diabetes-induced oxidative stress.

  Experimental diabetes research 20120101

• Comparative proteomic analysis of early salt stress-responsive proteins in roots of SnRK2 transgenic rice.

  Proteome science 20120101

• Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase.

  PloS one 20120101

• L(+) and D(-) lactate are increased in plasma and urine samples of type 2 diabetes as measured by a simultaneous quantification of L(+) and D(-) lactate by reversed-phase liquid chromatography tandem mass spectrometry.

  Experimental diabetes research 20120101

• Glyoxalase-I is a novel prognosis factor associated with gastric cancer progression.

  PloS one 20120101

• The Complexity of Sporadic Alzheimer's Disease Pathogenesis: The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction.

  International journal of Alzheimer's disease 20120101

• Major phenolic compounds, antioxidant capacity and antidiabetic potential of rice bean (Vigna umbellata L.) in China.

  International journal of molecular sciences 20120101

• Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes.

  International journal of vascular medicine 20120101

• Uptake and accumulation of oxidized low-density lipoprotein during Mycobacterium tuberculosis infection in guinea pigs.

  PloS one 20120101

• Effect of dietary advanced glycation end products on mouse liver.

  PloS one 20120101

• Glutathione homeostasis and functions: potential targets for medical interventions.

  Journal of amino acids 20120101

• Honey's Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition.

  Frontiers in microbiology 20120101

• Metabolomics analysis of Cistus monspeliensis leaf extract on energy metabolism activation in human intestinal cells.

  Journal of biomedicine & biotechnology 20120101

• Destabilization of the outer and inner mitochondrial membranes by core and linker histones.

  PloS one 20120101

• Paraoxonase 1 in chronic kidney failure.

  Journal of lipids 20120101

• Oxygen radical-mediated oxidation reactions of an alanine peptide motif - density functional theory and transition state theory study.

  Chemistry Central journal 20120101

• Transcriptional portrait of Actinobacillus pleuropneumoniae during acute disease--potential strategies for survival and persistence in the host.

  PloS one 20120101

• Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with type 2 diabetes uncontrolled by oral agents.

  Journal of diabetes and its complications 20120101

• Inflammation and the peritoneal membrane: causes and impact on structure and function during peritoneal dialysis.

  Mediators of inflammation 20120101

• Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes.

  PloS one 20120101

• Salmonella enterica: a surprisingly well-adapted intracellular lifestyle.

  Frontiers in microbiology 20120101

• Glyoxal formation and its role in endogenous oxalate synthesis.

  Advances in urology 20120101

• Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages.

  PloS one 20120101

• Aldose reductase, oxidative stress, and diabetic mellitus.

  Frontiers in pharmacology 20120101

• Methylglyoxal mediates adipocyte proliferation by increasing phosphorylation of Akt1.

  PloS one 20120101

• Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Identification of functional differences in metabolic networks using comparative genomics and constraint-based models.

  PloS one 20120101

• Role of operon aaoSo-mutT in antioxidant defense in Streptococcus oligofermentans.

  PloS one 20120101

• Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats.

  Oxidative medicine and cellular longevity 20120101

• Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies.

  Anemia 20120101

• Hyperglycemia increases muscle blood flow and alters endothelial function in adolescents with type 1 diabetes.

  Experimental diabetes research 20120101

• Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells.

  PloS one 20120101

• Purification and properties of S-hydroxymethylglutathione dehydrogenase of Paecilomyces variotii no. 5, a formaldehyde-degrading fungus.

  AMB Express 20120101

• Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney.

  Medical gas research 20120101

• Pathological significance of mitochondrial glycation.

  International journal of cell biology 20120101

• PanM, an acetyl-coenzyme A sensor required for maturation of L-aspartate decarboxylase (PanD).

  mBio 20120101

• A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration.

  PloS one 20120101

• [The role of oxidative processes in augmentation of atherogenity of low density lipoprotein particles].

  Kardiologiia 20120101

• [The influence of glucose on the free radical peroxidation of low density lipoproteins in vitro and in vivo].

  Biomeditsinskaia khimiia 20120101

• Methylglyoxal activates the human transient receptor potential ankyrin 1 channel.

  The Journal of toxicological sciences 20120101

• Aldolase B knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells.

  PloS one 20120101

• Inhibitory effects of hydroxysafflor yellow A on the formation of advanced glycation end products in vitro.

  Biological & pharmaceutical bulletin 20120101

• Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats.

  Journal of pharmacological sciences 20120101

• Inhibition of Advanced Glycation End-Product Formation by Origanum majorana L. In Vitro and in Streptozotocin-Induced Diabetic Rats.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Cleavage of α-dicarbonyl compounds by terpene hydroperoxide.

  Bioscience, biotechnology, and biochemistry 20120101

• Cytoplasmic and nuclear anti-apoptotic roles of αB-crystallin in retinal pigment epithelial cells.

  PloS one 20120101

• Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2.

  PloS one 20120101

• [Nonspecific inflammation and structural changes in the arteries of hypertensive males at high and moderate risk for cardiovascular events].

  Terapevticheskii arkhiv 20120101

• Late-onset running biphasically improves redox balance, energy- and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus.

  PloS one 20120101

• Generation of singlet oxygen by the glyoxal-peroxynitrite system.

  Journal of the American Chemical Society 20111228

• Multistep ultrahigh performance liquid chromatography/tandem mass spectrometry analysis for untargeted quantification of glycating activity and identification of most relevant glycation products.

  Analytical chemistry 20111215

• Chemical modifications of peptides and their impact on food properties.

  Chemical reviews 20111214

• Role of the glyoxalase system in astrocyte-mediated neuroprotection.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20111214

• Selenium-induced up-regulation of the antioxidant defense and methylglyoxal detoxification system reduces salinity-induced damage in rapeseed seedlings.

  Biological trace element research 20111201

• Selenium pretreatment upregulates the antioxidant defense and methylglyoxal detoxification system and confers enhanced tolerance to drought stress in rapeseed seedlings.

  Biological trace element research 20111201

• Development and validation of a selective HPLC-ESI-MS/MS method for the quantification of glyoxal and methylglyoxal in atmospheric aerosols (PM2.5).

  Analytical and bioanalytical chemistry 20111201

• Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome.

  Cardiovascular research 20111201

• The in vitro glycation of human serum albumin in the presence of Zn(II).

  Journal of inorganic biochemistry 20111201

• Protective measures against ultrafiltration failure in peritoneal dialysis patients.

  Clinics (Sao Paulo, Brazil) 20111201

• Cross-linking mechanisms of arginine and lysine with α,β-dicarbonyl compounds in aqueous solution.

  The journal of physical chemistry. A 20111124

• Moderate glycation of serum albumin affects folding, stability, and ligand binding.

  Clinica chimica acta; international journal of clinical chemistry 20111120

• Structural variation in bacterial glyoxalase I enzymes: investigation of the metalloenzyme glyoxalase I from Clostridium acetobutylicum.

  The Journal of biological chemistry 20111104

• Effect of micronutrients on methylglyoxal-mediated in vitro glycation of albumin.

  Biological trace element research 20111101

• Determination of time-dependent accumulation of D-lactate in the streptozotocin-induced diabetic rat kidney by column-switching HPLC with fluorescence detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• Comparison of glycation of glutathione S-transferase by methylglyoxal, glucose or fructose.

  Molecular and cellular biochemistry 20111101

• Association of two glyoxalase I gene polymorphisms with nephropathy and retinopathy in Type 2 diabetes.

  Journal of endocrinological investigation 20111101

• Transgenic potato overproducing L-ascorbic acid resisted an increase in methylglyoxal under salinity stress via maintaining higher reduced glutathione level and glyoxalase enzyme activity.

  Biotechnology letters 20111101

• Differential effects of insulin on peripheral diabetes-related changes in mitochondrial bioenergetics: involvement of advanced glycosylated end products.

  Biochimica et biophysica acta 20111101

• Role of age and uncoupling protein-2 in oxidative stress, RAGE/AGE interaction and inflammatory liver injury.

  Experimental gerontology 20111101

• Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E.

  Diabetologia 20111101

• Manuka honey inhibits cell division in methicillin-resistant Staphylococcus aureus.

  The Journal of antimicrobial chemotherapy 20111101

• Crh, the paralogue of the phosphocarrier protein HPr, controls the methylglyoxal bypass of glycolysis in Bacillus subtilis.

  Molecular microbiology 20111101

• Retinal pericytes inhibit activated T cell proliferation.

  Investigative ophthalmology & visual science 20111101

• Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals.

  Mechanisms of ageing and development 20111101

• [The glucose, glycotoxins and glycation products: the involvement into pathogenesis of microangiopathies, arteriolosclerosis and atherosclerosis].

  Klinicheskaia laboratornaia diagnostika 20111101

• Sensitive determination of glyoxal, methylglyoxal and hydroxyacetaldehyde in environmental water samples by using dansylacetamidooxyamine derivatization and liquid chromatography/fluorescence.

  Analytica chimica acta 20111017

• S-D-lactoylglutathione as a potential state marker for hemolysis.

  Medical hypotheses 20111001

• pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor.

  Biochimica et biophysica acta 20111001

• Fibrin(ogen) may be an important target for methylglyoxal-derived AGE modification in elastic arteries of humans.

  Diabetes & vascular disease research 20111001

• Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man.

  American journal of nephrology 20111001

• A pilot study on the use of serum glyoxalase as a supplemental biomarker to predict malignant cases of the prostate in the PSA range of 4-20 ng/ml.

  The Indian journal of medical research 20111001

• Methylglyoxal induces mitochondria-dependent apoptosis in sarcoma.

  Biochemistry. Biokhimiia 20111001

• Survey of 1,2-dicarbonyl compounds in commercial honey of different floral origin.

  Journal of food science 20111001

• Relationship of methylglyoxal-adduct biogenesis to LDL and triglyceride levels in diabetics.

  Life sciences 20110926

• Quantitative infrared intensity studies of vapor-phase glyoxal, methylglyoxal, and 2,3-butanedione (diacetyl) with vibrational assignments.

  The journal of physical chemistry. A 20110908

• Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells.

  Cell metabolism 20110907

• Meal-induced increases in C-reactive protein, interleukin-6 and tumour necrosis factor α are attenuated by prandial + basal insulin in patients with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20110901

• Methylglyoxal functions as Hill oxidant and stimulates the photoreduction of O(2) at photosystem I: a symptom of plant diabetes.

  Plant, cell & environment 20110901

• Energy metabolism and ageing regulation: metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction.

  Ageing research reviews 20110901

• Quantification of the six major α-dicarbonyl contaminants in peritoneal dialysis fluids by UHPLC/DAD/MSMS.

  Analytical and bioanalytical chemistry 20110901

• Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities.

  The Biochemical journal 20110901

• Differential inhibition/inactivation of mitochondrial complex I implicates its alteration in malignant cells.

  Biochemistry. Biokhimiia 20110901

• Amide bonds to the nitrogen atoms of cysteine and serine as 'weak points' in the backbones of proteins.

  Biochemistry 20110823

• Laboratory investigation on the role of organics in atmospheric nanoparticle growth.

  The journal of physical chemistry. A 20110818

• Dual effects of phloretin and phloridzin on the glycation induced by methylglyoxal in model systems.

  Chemical research in toxicology 20110815

• Taste modulating N-(1-methyl-4-oxoimidazolidin-2-ylidene) α-amino acids formed from creatinine and reducing carbohydrates.

  Journal of agricultural and food chemistry 20110810

• Glycation induction and antiglycation activity of skin care ingredients on living human skin explants.

  International journal of cosmetic science 20110801

• Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity--implications for autism.

  Autism research : official journal of the International Society for Autism Research 20110801

• Absolute configurations and stability of cyclic guanosine mono-adducts with glyoxal and methylglyoxal.

  Chirality 20110801

• Myoglobin-H2O2 catalyzes the oxidation of β-ketoacids to α-dicarbonyls: mechanism and implications in ketosis.

  Free radical biology & medicine 20110801

• Method for monitoring of the protein amino group changes during carbonylation.

  Clinical biochemistry 20110801

• Hsp31 of Escherichia coli K-12 is glyoxalase III.

  Molecular microbiology 20110801

• Cranberry phytochemicals inhibit glycation of human hemoglobin and serum albumin by scavenging reactive carbonyls.

  Food & function 20110801

• Polyamines in aging and disease.

  Aging 20110801

• Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosine.

  Molecular aspects of medicine 20110801

• Preferential recognition of methylglyoxal-modified calf thymus DNA by circulating antibodies in cancer patients.

  Indian journal of biochemistry & biophysics 20110801

• A global perspective of the genetic basis for carbonyl stress resistance.

  G3 (Bethesda, Md.) 20110801

• Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity.

  Journal of medicinal chemistry 20110728

• Diversity of plasmids encoding histidine decarboxylase gene in Tetragenococcus spp. isolated from Japanese fish sauce.

  International journal of food microbiology 20110715

• Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues.

  Biochemistry 20110712

• Carbonyl oxides reactions from geraniol-trans-(3,7-dimethylocta-2,6-dien-1-ol), 6-methyl-5-hepten-2-one, and 6-hydroxy-4-methyl-4-hexenal ozonolysis: kinetics and mechanisms.

  The journal of physical chemistry. A 20110707

• Pars plana vitrectomy for diabetic macular edema. Internal limiting membrane delamination vs posterior hyaloid removal. A prospective randomized trial.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20110701

• The genetic architecture of branched-chain amino acid accumulation in tomato fruits.

  Journal of experimental botany 20110701

• Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer.

  Biochimica et biophysica acta 20110701

• Functional and metabolic effects of adaptive glycerol kinase (GLPK) mutants in Escherichia coli.

  The Journal of biological chemistry 20110701

• Evidence that carbonyl stress by methylglyoxal exposure induces DNA damage and spindle aberrations, affects mitochondrial integrity in mammalian oocytes and contributes to oocyte ageing.

  Human reproduction (Oxford, England) 20110701

• Glycation of LDL by methylglyoxal increases arterial atherogenicity: a possible contributor to increased risk of cardiovascular disease in diabetes.

  Diabetes 20110701

• Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.

  Annals of neurology 20110701

• Distinct synergistic action of piperacillin and methylglyoxal against Pseudomonas aeruginosa.

  Indian journal of experimental biology 20110701

• In silico evidence for gluconeogenesis from fatty acids in humans.

  PLoS computational biology 20110701

• New site(s) of methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism.

  Chemico-biological interactions 20110630

• Catalytic conversion of dihydroxyacetone to lactic acid using metal salts in water.

  ChemSusChem 20110620

• 1,4-Diamino-2-butanone, a wide-spectrum microbicide, yields reactive species by metal-catalyzed oxidation.

  Free radical biology & medicine 20110615

• Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability.

  Human molecular genetics 20110615

• DNA damage induced by endogenous aldehydes: current state of knowledge.

  Mutation research 20110603

• The proglycation effect of caffeic acid leads to the elevation of oxidative stress and inflammation in monocytes, macrophages and vascular endothelial cells.

  The Journal of nutritional biochemistry 20110601

• Genome-wide analysis of rice and Arabidopsis identifies two glyoxalase genes that are highly expressed in abiotic stresses.

  Functional & integrative genomics 20110601

• Metabolic engineering of 1,2-propanediol pathways in Corynebacterium glutamicum.

  Applied microbiology and biotechnology 20110601

• Methylglyoxal and pulmonary hypertension in broiler chickens.

  Poultry science 20110601

• Trait variation in yeast is defined by population history.

  PLoS genetics 20110601

• Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.

  Interdisciplinary toxicology 20110601

• Developing resistance to aflatoxin in maize and cottonseed.

  Toxins 20110601

• Differences in glyoxal and methylglyoxal metabolism determine cellular susceptibility to protein carbonylation and cytotoxicity.

  Chemico-biological interactions 20110530

• Exogenous collagen crosslinking of the intervertebral disc restores joint stability after lumbar posterior decompression surgery.

  Spine 20110520

• Ex vivo detection of histone H1 modified with advanced glycation end products.

  Free radical biology & medicine 20110515

• Denuder sampling techniques for the determination of gas-phase carbonyl compounds: a comparison and characterisation of in situ and ex situ derivatisation methods.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110515

• Differential effects of advanced glycation end-products on renal tubular cell inflammation.

  Nephrology (Carlton, Vic.) 20110501

• Bacterial glyoxalase enzymes.

  Seminars in cell & developmental biology 20110501

• The glyoxalase system of malaria parasites--implications for cell biology and general glyoxalase research.

  Seminars in cell & developmental biology 20110501

• Glyoxalase system in yeasts: structure, function, and physiology.

  Seminars in cell & developmental biology 20110501

• Methylglyoxal metabolism in trypanosomes and leishmania.

  Seminars in cell & developmental biology 20110501

• Glyoxalase in tumourigenesis and multidrug resistance.

  Seminars in cell & developmental biology 20110501

• Glyoxalase in ageing.

  Seminars in cell & developmental biology 20110501

• Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501

• Glyoxalase in diabetes, obesity and related disorders.

  Seminars in cell & developmental biology 20110501

• An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

  European journal of medicinal chemistry 20110501

• Methylglyoxal-infused honey mimics the anti-Staphylococcus aureus biofilm activity of manuka honey: potential implication in chronic rhinosinusitis.

  The Laryngoscope 20110501

• Identification of H₂O₂ as a major antimicrobial component in coffee.

  Food & function 20110501

• Glycated AAV vectors: chemical redirection of viral tissue tropism.

  Bioconjugate chemistry 20110420

• Genistein inhibits advanced glycation end product formation by trapping methylglyoxal.

  Chemical research in toxicology 20110418

• Genotoxicity and immunogenicity of DNA-advanced glycation end products formed by methylglyoxal and lysine in presence of Cu2+.

  Biochemical and biophysical research communications 20110415

• Polyvinylamine-graft-TEMPO adsorbs onto, oxidizes, and covalently bonds to wet cellulose.

  Biomacromolecules 20110411

• Characteristic effects of methylglyoxal and its degraded product formate on viability of human histiocytes: a possible detoxification pathway of methylglyoxal.

  Biochemical and biophysical research communications 20110408

• Reduced glutathione concentrations are not decreased in red blood cells of patients with long term type 1-diabetes.

  Scandinavian journal of clinical and laboratory investigation 20110401

• Aspergillus nidulans transcription factor AtfA interacts with the MAPK SakA to regulate general stress responses, development and spore functions.

  Molecular microbiology 20110401

• Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study.

  Diabetes care 20110401

• The question is, my dear watson, why did the dog not bark?: the joslin 50-year medalist study.

  Diabetes care 20110401

• Efficiency of trapping methylglyoxal by phenols and phenolic acids.

  Journal of food science 20110401

• [Arteriolosclerosis and atherosclerosis. Pathology of the distal and proximal arterial bed. Pathogenesis of diabetic microangiopathy].

  Klinicheskaia laboratornaia diagnostika 20110401

• Mutagenesis and repair induced by the DNA advanced glycation end product N2-1-(carboxyethyl)-2'-deoxyguanosine in human cells.

  Biochemistry 20110329

• Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes.

  Chemico-biological interactions 20110315

• NADPH-dependent reductases involved in the detoxification of reactive carbonyls in plants.

  The Journal of biological chemistry 20110304

• Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy.

  Clinical biochemistry 20110301

• Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice.

  Diabetologia 20110301

• Overproduction of a rice aldo-keto reductase increases oxidative and heat stress tolerance by malondialdehyde and methylglyoxal detoxification.

  Plant molecular biology 20110301

• Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes.

  Diabetes 20110301

• Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.

  Diabetes 20110301

• Enhanced reactivity of Lys182 explains the limited efficacy of biogenic amines in preventing the inactivation of glucose-6-phosphate dehydrogenase by methylglyoxal.

  Bioorganic & medicinal chemistry 20110301

• Cloning and characterization of a glyoxalase I gene from the osmotolerant yeast Candida magnoliae.

  Journal of microbiology and biotechnology 20110301

• Chlorogenic acid inhibits the formation of advanced glycation end products and associated protein cross-linking.

  Archives of pharmacal research 20110301

• A matter of life or death: modeling DNA damage and repair in bacteria.

  Biophysical journal 20110216

• Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress.

  Cellular and molecular life sciences : CMLS 20110201

• Medical-grade honey enriched with antimicrobial peptides has enhanced activity against antibiotic-resistant pathogens.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20110201

• Identification of glycolaldehyde as the key inhibitor of bioethanol fermentation by yeast and genome-wide analysis of its toxicity.

  Biotechnology letters 20110201

• Networks of gene sharing among 329 proteobacterial genomes reveal differences in lateral gene transfer frequency at different phylogenetic depths.

  Molecular biology and evolution 20110201

• Peritoneal clearance and transport of methylglyoxal.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110201

• Formation of nitrogen-containing oligomers by methylglyoxal and amines in simulated evaporating cloud droplets.

  Environmental science & technology 20110201

• HdcB, a novel enzyme catalysing maturation of pyruvoyl-dependent histidine decarboxylase.

  Molecular microbiology 20110201

• Closing the anion gap: contribution of D-lactate to diabetic ketoacidosis.

  Clinica chimica acta; international journal of clinical chemistry 20110130

• Kinetics and mechanism of the glyoxal + HO2 reaction: conversion of HO2 to OH by carbonyls.

  The journal of physical chemistry. A 20110127

• Formation of carcinogenic 4(5)-methylimidazole in Maillard reaction systems.

  Journal of agricultural and food chemistry 20110126

• Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats.

  The Journal of biological chemistry 20110114

• Formation of arginine modifications in a model system of Nα-tert-butoxycarbonyl (Boc)-arginine with methylglyoxal.

  Journal of agricultural and food chemistry 20110112

• Effects of ethyl pyruvate and other α-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion.

  The Journal of surgical research 20110101

• Renal podocyte apoptosis in Zucker diabetic fatty rats: involvement of methylglyoxal-induced oxidative DNA damage.

  Journal of comparative pathology 20110101

• Thermal analysis reveals differential effects of various crosslinkers on bovine annulus fibrosis.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110101

• Optimization of protein crosslinking formulations for the treatment of degenerative disc disease.

  Spine 20110101

• The influence of bicarbonate/lactate-buffered PD fluids on N{ε}-(carboxyethyl)lysine and N{ε}-(carboxymethyl)lysine in peritoneal effluent.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20110101

• Monitoring nonenzymatic glycation of human immunoglobulin G by methylglyoxal and glyoxal: A spectroscopic study.

  Analytical biochemistry 20110101

• YqhD: a broad-substrate range aldehyde reductase with various applications in production of biorenewable fuels and chemicals.

  Applied microbiology and biotechnology 20110101

• Reactive metabolites and AGE/RAGE-mediated cellular dysfunction affect the aging process: a mini-review.

  Gerontology 20110101

• Selection for low or high primary dormancy in Lolium rigidum Gaud seeds results in constitutive differences in stress protein expression and peroxidase activity.

  Journal of experimental botany 20110101

• The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.

  Genetics 20110101

• Diabetic retinopathy: targeting vasoregression.

  Diabetes 20110101

• Proximal tubule cell hypothesis for cardiorenal syndrome in diabetes.

  International journal of nephrology 20110101

• A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture.

  BMC systems biology 20110101

• The role of glyoxalases for sugar stress and aging, with relevance for dyskinesia, anxiety, dementia and Parkinson's disease.

  Aging 20110101

• Proteomics analysis of methylglyoxal-induced neurotoxic effects in SH-SY5Y cells.

  Cell biochemistry and function 20110101

• The glyoxalase system as an example of a cellular maintenance pathway with relevance to aging.

  Aging 20110101

• Group II intron-anchored gene deletion in Clostridium.

  PloS one 20110101

• Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury.

  PloS one 20110101

• A synthetic library of RNA control modules for predictable tuning of gene expression in yeast.

  Molecular systems biology 20110101

• Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.

  PloS one 20110101

• Characterization of proteome alterations in Phanerochaete chrysosporium in response to lead exposure.

  Proteome science 20110101

• Two major medicinal honeys have different mechanisms of bactericidal activity.

  PloS one 20110101

• Role of advanced glycation on aggregation and DNA binding properties of α-synuclein.

  Journal of Alzheimer's disease : JAD 20110101

• Carotid intima-media thickness as a surrogate marker of cardiovascular disease in diabetes.

  Diabetes, metabolic syndrome and obesity : targets and therapy 20110101

• The antibacterial activity of honey derived from Australian flora.

  PloS one 20110101

• Accumulation of renin and imidazolone in peritubular capillary endothelial cells in insulin-resistant hypertensive rats.

  Journal of nephrology 20110101

• Evidence for reductive genome evolution and lateral acquisition of virulence functions in two Corynebacterium pseudotuberculosis strains.

  PloS one 20110101

• Binge-pattern alcohol exposure during puberty induces long-term changes in HPA axis reactivity.

  PloS one 20110101

• Photodynamic treatment induces an apoptotic pathway involving calcium, nitric oxide, p53, p21-activated kinase 2, and c-Jun N-terminal kinase and inactivates survival signal in human umbilical vein endothelial cells.

  International journal of molecular sciences 20110101

• Postmyocardial infarct remodeling and heart failure: potential contributions from pro- and antiaging factors.

  Cardiology research and practice 20110101

• Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features.

  PloS one 20110101

• Strain engineering for improved expression of recombinant proteins in bacteria.

  Microbial cell factories 20110101

• Modification of collagen by 3-deoxyglucosone alters wound healing through differential regulation of p38 MAP kinase.

  PloS one 20110101

• AGE-BSA down-regulates endothelial connexin43 gap junctions.

  BMC cell biology 20110101

• An active site aromatic triad in Escherichia coli DNA Pol IV coordinates cell survival and mutagenesis in different DNA damaging agents.

  PloS one 20110101

• The antioxidative effect of electro-acupuncture in a mouse model of Parkinson's disease.

  PloS one 20110101

• Global analysis of gene expression in response to L-Cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica.

  BMC genomics 20110101

• Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence.

  PloS one 20110101

• Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy.

  Molecular vision 20110101

• The metabolic advantage of tumor cells.

  Molecular cancer 20110101

• Chemical linkage to injected tissues is a distinctive property of oxidized avidin.

  PloS one 20110101

• Global transcriptome response in Lactobacillus sakei during growth on ribose.

  BMC microbiology 20110101

• Intuitive visualization and analysis of multi-omics data and application to Escherichia coli carbon metabolism.

  PloS one 20110101

• Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes.

  PloS one 20110101

• Immortalized adult rodent Schwann cells as in vitro models to study diabetic neuropathy.

  Experimental diabetes research 20110101

• Intermittent high glucose enhances apoptosis in INS-1 cells.

  Experimental diabetes research 20110101

• Vascular homeostasis and angiogenesis determine therapeutic effectiveness in type 2 diabetes.

  International journal of vascular medicine 20110101

• Control of genetically prescribed protein tyrosine kinase activities by environment-linked redox reactions.

  Enzyme research 20110101

• Methylglyoxal-a potential risk factor of manuka honey in healing of diabetic ulcers.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Synergistic use of plant-prokaryote comparative genomics for functional annotations.

  BMC genomics 20110101

• Identification of host genes involved in geminivirus infection using a reverse genetics approach.

  PloS one 20110101

• Insulin glycation by methylglyoxal results in native-like aggregation and inhibition of fibril formation.

  BMC biochemistry 20110101

• Proteomic analysis reveals that iron availability alters the metabolic status of the pathogenic fungus Paracoccidioides brasiliensis.

  PloS one 20110101

• Catabolic regulation analysis of Escherichia coli and its crp, mlc, mgsA, pgi and ptsG mutants.

  Microbial cell factories 20110101

• Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols.

  Molecular vision 20110101

• Protein profiling of human nonpigmented ciliary epithelium cell secretome: the differentiation factors characterization for retinal ganglion cell line.

  Journal of biomedicine & biotechnology 20110101

• NF-κB-inducing kinase increases renal tubule epithelial inflammation associated with diabetes.

  Experimental diabetes research 20110101

• Polymicrobial Sepsis in an Immunocompetent Host due to Self Injection of Urine.

  Journal of global infectious diseases 20110101

• Update on the management of diabetic polyneuropathies.

  Diabetes, metabolic syndrome and obesity : targets and therapy 20110101

• Glucose and its metabolites have distinct effects on the calcium-induced mitochondrial permeability transition.

  Folia biologica 20110101

• Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice.

  Molecular vision 20110101

• Effect of exposure of human monocyte-derived macrophages to high, versus normal, glucose on subsequent lipid accumulation from glycated and acetylated low-density lipoproteins.

  Experimental diabetes research 20110101

• Isoflurane's Effect on Protein Conformation as a Proposed Mechanism for Preconditioning.

  Biochemistry research international 20110101

• Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis.

  PloS one 20110101

• D-ribose induces cellular protein glycation and impairs mouse spatial cognition.

  PloS one 20110101

• Tmem26 is dynamically expressed during palate and limb development but is not required for embryonic survival.

  PloS one 20110101

• Horizontal and vertical growth of S. cerevisiae metabolic network.

  BMC evolutionary biology 20110101

• Different impacts of cardiovascular risk factors on oxidative stress.

  International journal of molecular sciences 20110101

• Cumulative number of cell divisions as a meaningful timescale for adaptive laboratory evolution of Escherichia coli.

  PloS one 20110101

• Beyond genetic factors in familial amyloidotic polyneuropathy: protein glycation and the loss of fibrinogen's chaperone activity.

  PloS one 20110101

• Biological potential of sixteen legumes in China.

  International journal of molecular sciences 20110101

• DNA microarray analysis of the epithelial-mesenchymal transition of mesothelial cells in a rat model of peritoneal dialysis.

  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20110101

• Dehydratase mediated 1-propanol production in metabolically engineered Escherichia coli.

  Microbial cell factories 20110101

• CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.

  PloS one 20110101

• Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal Activity.

  Molecular biology international 20110101

• Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms.

  Journal of toxicology 20110101

• Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy.

  Journal of ophthalmology 20110101

• Endoplasmic reticulum stress pathway-mediated apoptosis in macrophages contributes to the survival of Mycobacterium tuberculosis.

  PloS one 20110101

• Increased renal methylglyoxal formation with down-regulation of PGC-1α-FBPase pathway in cystathionine γ-lyase knockout mice.

  PloS one 20110101

• Modification of lipoprotein(a) by natural dicarbonyls induced their following free radical peroxidation.

  Doklady. Biochemistry and biophysics 20110101

• Osmolarity and glucose differentially regulate aldose reductase activity in cultured mouse podocytes.

  Experimental diabetes research 20110101

• Methylglyoxal: (active agent of manuka honey) in vitro activity against bacterial biofilms.

  International forum of allergy & rhinology 20110101

• Protein modification by dicarbonyl molecular species in neurodegenerative diseases.

  Journal of amino acids 20110101

• Defining the plant peroxisomal proteome: from Arabidopsis to rice.

  Frontiers in plant science 20110101

• The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas.

  Pathobiology of aging & age related diseases 20110101

• Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndrome.

  Toxicology 20101230

• Metabolome analysis revealed increase in S-methylcysteine and phosphatidylisopropanolamine synthesis upon L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica.

  The Journal of biological chemistry 20101210

• Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose.

  British journal of pharmacology 20101201

• Eicosapentaenoic acid restores diabetic tubular injury through regulating oxidative stress and mitochondrial apoptosis.

  American journal of physiology. Renal physiology 20101201

• Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function.

  Diabetes 20101201

• The critical role of S-lactoylglutathione formation during methylglyoxal detoxification in Escherichia coli.

  Molecular microbiology 20101201

• Ketonuria after fasting may be related to the metabolic superiority.

  Journal of Korean medical science 20101201

• Compartmentation of redox metabolism in malaria parasites.

  PLoS pathogens 20101201

• Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan.

  Aging 20101201

• Acid-base disorders in ICU patients.

  Electrolyte & blood pressure : E & BP 20101201

• Dietary advanced glycation end products and aging.

  Nutrients 20101201

• Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution.

  Journal of molecular biology 20101119

• Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10).

  Archives of biochemistry and biophysics 20101115

• Model representation of secondary organic aerosol in CMAQv4.7.

  Environmental science & technology 20101115

• Acetyl radical production by the methylglyoxal-peroxynitrite system: a possible route for L-lysine acetylation.

  Chemical research in toxicology 20101115

• 2-DE based proteomic analysis of Saccharomyces cerevisiae wild and K+ transport-affected mutant (trk1,2) strains at the growth exponential and stationary phases.

  Journal of proteomics 20101110

• Effect of methylglyoxal modification of human α-crystallin on the structure, stability and chaperone function.

  The protein journal 20101101

• Relationship between Pentosidine and Pyridinoline Levels in Human Diabetic Cataract Lenses.

  Journal of clinical biochemistry and nutrition 20101101

• Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies.

  The Journal of biological chemistry 20101029

• Tenuigenin protects cultured hippocampal neurons against methylglyoxal-induced neurotoxicity.

  European journal of pharmacology 20101025

• 3-deoxygalactosone, a 'new' 1,2-dicarbonyl compound in milk products.

  Journal of agricultural and food chemistry 20101013

• Cytotoxic role of methylglyoxal in rat retinal pericytes: Involvement of a nuclear factor-kappaB and inducible nitric oxide synthase pathway.

  Chemico-biological interactions 20101006

• Influence of the microenvironment of thiol groups in low molecular mass thiols and serum albumin on the reaction with methylglyoxal.

  Chemico-biological interactions 20101006

• Advanced glycation end products as biomarkers and gerontotoxins - A basis to explore methylglyoxal-lowering agents for Alzheimer's disease?

  Experimental gerontology 20101001

• Subcellular distribution of glutathione and cysteine in cyanobacteria.

  Protoplasma 20101001

• Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38.

  Molecular nutrition & food research 20101001

• Mitochondrial aldehyde dehydrogenase and cardiac diseases.

  Cardiovascular research 20101001

• Maternally transmitted and food-derived glycotoxins: a factor preconditioning the young to diabetes?

  Diabetes care 20101001

• Proteotoxicity and the contrasting effects of oxaloacetate and glycerol on Caenorhabditis elegans life span: a role for methylglyoxal?

  Rejuvenation research 20101001

• Aldose reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats.

  Aging cell 20101001

• Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I.

  Bioorganic & medicinal chemistry 20101001

• Skin wound healing in diabetic β6 integrin-deficient mice.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20101001

• Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20101001

• Genomic damage in endstage renal disease-contribution of uremic toxins.

  Toxins 20101001

• Formation yields of glyoxal and methylglyoxal from the gas-phase OH radical-initiated reactions of toluene, xylenes, and trimethylbenzenes as a function of NO2 concentration.

  The journal of physical chemistry. A 20100923

• Evidence of reactive aromatics as a major source of peroxy acetyl nitrate over China.

  Environmental science & technology 20100915

• Redox homeostasis, antioxidant defense, and methylglyoxal detoxification as markers for salt tolerance in Pokkali rice.

  Protoplasma 20100901

• A study of D-lactate and extracellular methylglyoxal production in lactate re-utilizing CHO cultures.

  Biotechnology and bioengineering 20100901

• Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis.

  Free radical biology & medicine 20100901

• Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.

  Experimental physiology 20100901

• Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure.

  Hypertension (Dallas, Tex. : 1979) 20100901

• In-cloud multiphase behaviour of acetone in the troposphere: gas uptake, Henry's law equilibrium and aqueous phase photooxidation.

  Chemosphere 20100901

• Multi-parameter detection of diabetes mellitus on multichannel poly(dimethylsiloxane) analytical chips coupled with nanoband microelectrode arrays.

  Electrophoresis 20100901

• Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents.

  Chemical & pharmaceutical bulletin 20100901

• Glyoxal-methylglyoxal cross-reactions in secondary organic aerosol formation.

  Environmental science & technology 20100815

• Comparative proteomic analysis of early-stage soybean seedlings responses to flooding by using gel and gel-free techniques.

  Journal of proteome research 20100806

• Transient inhibition of transforming growth factor-beta1 in human diabetic CD34+ cells enhances vascular reparative functions.

  Diabetes 20100801

• Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity.

  American journal of physiology. Endocrinology and metabolism 20100801

• Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse.

  Diabetes 20100801

• Rapid profiling of a microbial genome using mixtures of barcoded oligonucleotides.

  Nature biotechnology 20100801

• Methylglyoxal content in drinking coffee as a cytotoxic factor.

  Journal of food science 20100801

• O-GlcNAc Modification: Friend or Foe in Diabetic Cardiovascular Disease.

  Korean diabetes journal 20100801

• A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.

  Nature communications 20100801

• Interrelation between malonyl dialdehyde-dependent modification and cholesterol content in low-density lipoproteins.

  Bulletin of experimental biology and medicine 20100801

• A novel capillary electrophoretic method for determining methylglyoxal and glyoxal in urine and water samples.

  Journal of chromatography. A 20100730

• Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment.

  Cell death and differentiation 20100701

• How honey kills bacteria.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100701

• Infusion fluids contain harmful glucose degradation products.

  Intensive care medicine 20100701

• Methylglyoxal-modified collagen promotes myofibroblast differentiation.

  Matrix biology : journal of the International Society for Matrix Biology 20100701

• Characterization of the branched-chain amino acid aminotransferase enzyme family in tomato.

  Plant physiology 20100701

• Glycobiology of the Leishmania parasite and emerging targets for antileishmanial drug discovery.

  Expert opinion on therapeutic targets 20100701

• Fructose and cardiometabolic disorders: the controversy will, and must, continue.

  Clinics (Sao Paulo, Brazil) 20100701

• The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.

  The Plant cell 20100701

• Role of Lys-12 in catalysis by triosephosphate isomerase: a two-part substrate approach.

  Biochemistry 20100629

• KIOM-79 prevents methyglyoxal-induced retinal pericyte apoptosis in vitro and in vivo.

  Journal of ethnopharmacology 20100616

• Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway.

  The Journal of biological chemistry 20100611

• Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption.

  Journal of agricultural and food chemistry 20100609

• Methylglyoxal modulates immune responses: relevance to diabetes.

  Journal of cellular and molecular medicine 20100601

• Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: possible links between diabetes and atherosclerosis.

  Biochimica et biophysica acta 20100601

• Evaluation of dicarbonyls generated in a simulated indoor air environment using an in vitro exposure system.

  Toxicological sciences : an official journal of the Society of Toxicology 20100601

• NAD(+) and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?

  Experimental gerontology 20100601

• Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain.

  Journal of neurochemistry 20100601

• Isoflurane's effect on interfacial dynamics in GAPDH influences methylglyoxal reactivity.

  Archives of biochemistry and biophysics 20100601

• Neuropathy, retinopathy, and glucose-lowering treatments.

  Diabetes care 20100601

• Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine.

  Clinics (Sao Paulo, Brazil) 20100601

• Interaction of methylglyoxal and hydrogen sulfide in rat vascular smooth muscle cells.

  Antioxidants & redox signaling 20100501

• Methylglyoxal activates Gcn2 to phosphorylate eIF2alpha independently of the TOR pathway in Saccharomyces cerevisiae.

  Applied microbiology and biotechnology 20100501

• Glycation of PDGF results in decreased biological activity.

  The international journal of biochemistry & cell biology 20100501

• Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.

  Diabetologia 20100501

• Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of glyoxalase I from Leishmania infantum.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20100501

• Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria.

  The Plant cell 20100501

• Cytoprotection by almond skin extracts or catechins of hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) versus glyoxal or methylglyoxal (carbonylation model).

  Chemico-biological interactions 20100429

• Molecular gastronomy: a new emerging scientific discipline.

  Chemical reviews 20100414

• Lipid peroxidation in relation to ageing and the role of endogenous aldehydes in diabetes and other age-related diseases.

  Ageing research reviews 20100401

• Fructose and moderately high dietary salt-induced hypertension: prevention by a combination of N-acetylcysteine and L-arginine.

  Molecular and cellular biochemistry 20100401

• Modulation of advanced glycation endproduct synthesis by kynurenines in human lens proteins.

  Biochimica et biophysica acta 20100401

• Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin.

  Diabetes 20100401

• Kinetic characterization and comparison of various protein crosslinking reagents for matrix modification.

  Journal of materials science. Materials in medicine 20100401

• Hydroimidazolone modification of human alphaA-crystallin: Effect on the chaperone function and protein refolding ability.

  Biochimica et biophysica acta 20100401

• GLO1 overexpression in human malignant melanoma.

  Melanoma research 20100401

• Methylglyoxal has injurious effects on maturation of mouse oocytes, fertilization, and fetal development, via apoptosis.

  Toxicology letters 20100401

• Protein modification and replicative senescence of WI-38 human embryonic fibroblasts.

  Aging cell 20100401

• Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I.

  Arteriosclerosis, thrombosis, and vascular biology 20100401

• Distinct subcellular localization in the cytosol and apicoplast, unexpected dimerization and inhibition of Plasmodium falciparum glyoxalases.

  Molecular microbiology 20100401

• A matter of degrees: advancing our understanding of acrylamide.

  Environmental health perspectives 20100401

• Identification of adducts formed in the reactions of malonaldehyde-glyoxal and malonaldehyde-methylglyoxal with adenosine and calf thymus DNA.

  Chemistry & biodiversity 20100401

• Discovery and characterization of proteins associated with aflatoxin-resistance: evaluating their potential as breeding markers.

  Toxins 20100401

• Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca(2+) in Saccharomyces cerevisiae.

  The Biochemical journal 20100329

• Analysis, distribution, and dietary exposure of glyoxal and methylglyoxal in cookies and their relationship with other heat-induced contaminants.

  Journal of agricultural and food chemistry 20100310

• Mutagenic potential of DNA glycation: miscoding by (R)- and (S)-N2-(1-carboxyethyl)-2'-deoxyguanosine.

  Biochemistry 20100309

• Effect of reactive-aldehydes on the modification and dysfunction of human serum albumin.

  Journal of pharmaceutical sciences 20100301

• Two dicarbonyl compounds, 3-deoxyglucosone and methylglyoxal, differentially modulate dermal fibroblasts.

  Matrix biology : journal of the International Society for Matrix Biology 20100301

• AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease.

  American journal of physiology. Cell physiology 20100301

• Rutin metabolites: novel inhibitors of nonoxidative advanced glycation end products.

  Free radical biology & medicine 20100301

• Hyperglycemia impairs proteasome function by methylglyoxal.

  Diabetes 20100301

• Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis.

  Biophysical chemistry 20100301

• Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans.

  Eukaryotic cell 20100301

• Inhibition of L-arginine metabolizing enzymes by L-arginine-derived advanced glycation end products.

  Journal of clinical biochemistry and nutrition 20100301

• Oxidative stress and aging: is methylglyoxal the hidden enemy?

  Canadian journal of physiology and pharmacology 20100301

• [Methylglyoxal--a test for impaired biological functions of exotrophy and endoecology, low glucose level in the cytosol and gluconeogenesis from fatty acids (a lecture)].

  Klinicheskaia laboratornaia diagnostika 20100301

• Different experimental approaches in modelling cataractogenesis: An overview of selenite-induced nuclear cataract in rats.

  Interdisciplinary toxicology 20100301

• The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity.

  Cell death & disease 20100301

• Microbial production and applications of 1,2-propanediol.

  Indian journal of microbiology 20100301

• Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice.

  European journal of pharmacology 20100225

• Stilbene glucoside from Polygonum multiflorum Thunb.: a novel natural inhibitor of advanced glycation end product formation by trapping of methylglyoxal.

  Journal of agricultural and food chemistry 20100224

• Formation of pyrazines in Maillard model systems of lysine-containing dipeptides.

  Journal of agricultural and food chemistry 20100224

• Effects of glyoxal or methylglyoxal on the metabolism of amino acids, lactate, glucose and acetate in the cerebral cortex of young and adult rats.

  Brain research 20100222

• Molecular cloning and characterization of a novel glyoxalase I gene TaGly I in wheat (Triticum aestivum L.).

  Molecular biology reports 20100201

• Thioflavin T fluorescence in human serum: correlations with vascular health and cardiovascular risk factors.

  Clinical biochemistry 20100201

• Structural biology of S-adenosylmethionine decarboxylase.

  Amino acids 20100201

• Incretin concepts.

  Diabetes care 20100201

• Glycotoxines, carbonyl stress and relevance to diabetes and its complications.

  Physiological research 20100101

• Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine protection.

  Molecular and cellular biochemistry 20100101

• Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands.

  Diabetes 20100101

• Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells.

  Free radical research 20100101

• Impact of low glucose degradation product bicarbonate/lactate-buffered dialysis solution on the epithelial-mesenchymal transition of peritoneum.

  American journal of nephrology 20100101

• Methylglyoxal induces cellular damage by increasing argpyrimidine accumulation and oxidative DNA damage in human lens epithelial cells.

  Biochemical and biophysical research communications 20100101

• Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats.

  British journal of pharmacology 20100101

• HIF-1alpha dysfunction in diabetes.

  Cell cycle (Georgetown, Tex.) 20100101

• The path to next generation biofuels: successes and challenges in the era of synthetic biology.

  Microbial cell factories 20100101

• The plastid isoform of triose phosphate isomerase is required for the postgerminative transition from heterotrophic to autotrophic growth in Arabidopsis.

  The Plant cell 20100101

• Pyrosequencing of Mytilus galloprovincialis cDNAs: tissue-specific expression patterns.

  PloS one 20100101

• Protein antioxidant response to the stress and the relationship between molecular structure and antioxidant function.

  PloS one 20100101

• Methylglyoxal enhances sodium nitroprusside-induced relaxation in rat aorta.

  Journal of pharmacological sciences 20100101

• The role of glyoxalase system in renal hypoxia.

  Advances in experimental medicine and biology 20100101

• [Glycation of mitochondrial proteins, oxidative stress and aging].

  Revista espanola de geriatria y gerontologia 20100101

• Female reproductive dysfunction during ageing: role of methylglyoxal in the formation of advanced glycation endproducts in ovaries of reproductively-aged mice.

  Journal of biological regulators and homeostatic agents 20100101

• Metabolic engineering of glyoxalase pathway for enhancing stress tolerance in plants.

  Methods in molecular biology (Clifton, N.J.) 20100101

• Buthionine sulfoximine promotes methylglyoxal-induced apoptotic cell death and oxidative stress in endothelial cells.

  Biological & pharmaceutical bulletin 20100101

• OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains.

  BMC systems biology 20100101

• Increased concentration of two different advanced glycation end-products detected by enzyme immunoassays with new monoclonal antibodies in sera of patients with rheumatoid arthritis.

  BMC musculoskeletal disorders 20100101

• Peritoneal adipocytes and their role in inflammation during peritoneal dialysis.

  Mediators of inflammation 20100101

• Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents.

  Journal of oncology 20100101

• Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation.

  PloS one 20100101

• Identification of the primary structure and post-translational modification of rat S-adenosylmethionine decarboxylase.

  Biological & pharmaceutical bulletin 20100101

• Engineering cofactor preference of ketone reducing biocatalysts: A mutagenesis study on a γ-diketone reductase from the yeast Saccharomyces cerevisiae serving as an example.

  International journal of molecular sciences 20100101

• Mitochondrial dysfunction, proteotoxicity, and aging: causes or effects, and the possible impact of NAD+-controlled protein glycation.

  Advances in clinical chemistry 20100101

• Identification of latexin by a proteomic analysis in rat normal articular cartilage.

  Proteome science 20100101

• Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations.

  PloS one 20100101

• Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence.

  BMC genomics 20100101

• Aging, Proteotoxicity, Mitochondria, Glycation, NAD and Carnosine: Possible Inter-Relationships and Resolution of the Oxygen Paradox.

  Frontiers in aging neuroscience 20100101

• Precursor of advanced glycation end products mediates ER-stress-induced caspase-3 activation of human dermal fibroblasts through NAD(P)H oxidase 4.

  PloS one 20100101

• Effect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistance.

  Diabetology & metabolic syndrome 20100101

• Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus.

  Mediators of inflammation 20100101

• Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy.

  Journal of ophthalmology 20100101

• Inhibition of methylglyoxal-mediated protein modification in glyoxalase I overexpressing mouse lenses.

  Journal of ophthalmology 20100101

• The glycobiome of the rumen bacterium Butyrivibrio proteoclasticus B316(T) highlights adaptation to a polysaccharide-rich environment.

  PloS one 20100101

• Redox homeostasis of albumin in relation to alpha-lipoic acid and dihydrolipoic acid.

  Oxidative medicine and cellular longevity 20100101

• Bench-to-bedside review: Glucose and stress conditions in the intensive care unit.

  Critical care (London, England) 20100101

• Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats.

  Molecular vision 20100101

• An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages.

  PloS one 20100101

• Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.

  BMC complementary and alternative medicine 20100101

• Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network.

  Molecular systems biology 20100101

• The ubiquitous conserved glycopeptidase Gcp prevents accumulation of toxic glycated proteins.

  mBio 20100101

• Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes.

  Arthritis research & therapy 20100101

• The genome of Geobacter bemidjiensis, exemplar for the subsurface clade of Geobacter species that predominate in Fe(III)-reducing subsurface environments.

  BMC genomics 20100101

• Methylglyoxal alters the function and stability of critical components of the protein quality control.

  PloS one 20100101

• Elementary mode analysis for the rational design of efficient succinate conversion from glycerol by Escherichia coli.

  Journal of biomedicine & biotechnology 20100101

• Architecture of y-family DNA polymerases relevant to translesion DNA synthesis as revealed in structural and molecular modeling studies.

  Journal of nucleic acids 20100101

• Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence.

  BMC genomics 20100101

• The effects of methylglyoxal on glutathione S-transferase from Nicotiana tabacum.

  Bioscience, biotechnology, and biochemistry 20100101

• Proline and glycinebetaine ameliorated NaCl stress via scavenging of hydrogen peroxide and methylglyoxal but not superoxide or nitric oxide in tobacco cultured cells.

  Bioscience, biotechnology, and biochemistry 20100101

• Molecular mechanisms of persistence of mutualistic bacteria Photorhabdus in the entomopathogenic nematode host.

  PloS one 20100101

• Diagnostic potential of plasma carboxymethyllysine and carboxyethyllysine in multiple sclerosis.

  Journal of neuroinflammation 20100101

• Rat aldose reductase-like protein (AKR1B14) efficiently reduces the lipid peroxidation product 4-oxo-2-nonenal.

  Biological & pharmaceutical bulletin 20100101

• New horizons in research on diabetic complications of the eye: special emphasis on diabetic cataracts and retinopathy.

  Journal of ophthalmology 20100101

• Methylglyoxal augments angiotensin II-induced contraction in rat isolated carotid artery.

  Journal of pharmacological sciences 20100101

• Apoplast proteome reveals that extracellular matrix contributes to multistress response in poplar.

  BMC genomics 20100101

• The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal.

  PloS one 20100101

• TF-centered downstream gene set enrichment analysis: Inference of causal regulators by integrating TF-DNA interactions and protein post-translational modifications information.

  BMC bioinformatics 20100101

• Experimental study of photooxidation products of ethylbenzene.

  Journal of environmental sciences (China) 20100101

• Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.

  The open cardiovascular medicine journal 20100101

• Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy.

  Experimental diabetes research 20100101

• [Methylglyoxal--test for biological dysfunctions of homeostasis and endoecology, low cytosolic glucose level, and gluconeogenesis from fatty acids].

  Terapevticheskii arkhiv 20100101

• Ageing and its implications.

  Journal of oral and maxillofacial pathology : JOMFP 20100101

• A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coli.

  Advances and applications in bioinformatics and chemistry : AABC 20100101

• Role of methylglyoxal in essential hypertension.

  The International journal of angiology : official publication of the International College of Angiology, Inc 20100101

• Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.

  The Journal of biological chemistry 20091211

• Glyoxalase I activity and immunoreactivity in the aging human lens.

  Biogerontology 20091201

• Hyperglycemia and glycation in diabetic complications.

  Antioxidants & redox signaling 20091201

• Food derived carbonyl compounds affect basal and stimulated secretion of interleukin-6 and -8 in Caco-2 cells.

  European journal of nutrition 20091201

• 'Blinding' of AMP-dependent kinase by methylglyoxal: a mechanism that allows perpetuation of hepatic insulin resistance?

  Medical hypotheses 20091201

• Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes.

  Diabetes 20091201

• Triosephosphate isomerase deficiency: new insights into an enigmatic disease.

  Biochimica et biophysica acta 20091201

• Carbonated soft drinks and carbonyl stress burden.

  The Journal of toxicological sciences 20091201

• Methylglyoxal causes dysfunction of thioredoxin and thioredoxin reductase in endothelial cells.

  Journal of pharmacological sciences 20091201

• Generation of a rat monoclonal antibody specific for glyoxalase I.

  Hybridoma (2005) 20091201

• Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20091201

• Profiling of alpha-dicarbonyl content of commercial honeys from different botanical origins: identification of 3,4-dideoxyglucoson-3-ene (3,4-DGE) and related compounds.

  Journal of agricultural and food chemistry 20091125

• Crystalline silica Min-U-Sil 5 induces oxidative stress in human bronchial epithelial cells BEAS-2B by reducing the efficiency of antiglycation and antioxidant enzymatic defenses.

  Chemico-biological interactions 20091110

• Glycation of aspartate aminotransferase by methylglyoxal, effect of hydroxycitric and uric acid.

  Molecular and cellular biochemistry 20091101

• Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue.

  Diabetes 20091101

• C. elegans as model for the study of high glucose- mediated life span reduction.

  Diabetes 20091101

• Antioxidant anti-inflammatory treatment in type 2 diabetes.

  Diabetes care 20091101

• Shifting the disease management paradigm from glucose: what are the pros?

  Diabetes care 20091101

• Effects of precursor concentration and acidic sulfate in aqueous glyoxal-OH radical oxidation and implications for secondary organic aerosol.

  Environmental science & technology 20091101

• Secondary organic aerosol formation by self-reactions of methylglyoxal and glyoxal in evaporating droplets.

  Environmental science & technology 20091101

• 3-(6-Methyl-2-pyrid-yl)-2-phenyl-3,4-dihydro-1,3,2-benzoxaza-phosphinine 2-oxide.

  Acta crystallographica. Section E, Structure reports online 20091101

• [Effects of N-acetylcysteine upon methylglyoxal-induced damage in hippocampal neuronal cells].

  Zhonghua yi xue za zhi 20091027

• Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions.

  Journal of the American Society of Nephrology : JASN 20091001

• Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.

  Hypertension (Dallas, Tex. : 1979) 20091001

• Critical evaluation of toxic versus beneficial effects of methylglyoxal.

  Biochemistry. Biokhimiia 20091001

• Chemical and functional aspects of posttranslational modification of proteins.

  Acta naturae 20091001

• Degradation of glucose: reinvestigation of reactive alpha-Dicarbonyl compounds.

  Journal of agricultural and food chemistry 20090923

• Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway.

  Neuroscience 20090915

• Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways.

  The Journal of biological chemistry 20090911

• Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins.

  Fitoterapia 20090901

• Deletion of methylglyoxal synthase gene (mgsA) increased sugar co-metabolism in ethanol-producing Escherichia coli.

  Biotechnology letters 20090901

• Hyperglycaemia impairs antithrombin secretion: possible contribution to the thrombotic risk of diabetes.

  Thrombosis research 20090901

• Evaluation of the toxicity of stress-related aldehydes to photosynthesis in chloroplasts.

  Planta 20090901

• Methylglyoxal: possible link between hyperglycaemia and immune suppression?

  Trends in endocrinology and metabolism: TEM 20090901

• ATP regulates calcium efflux and growth in E. coli.

  Journal of molecular biology 20090807

• Regio- and chemoselective multiple functionalization of chloropyrazine derivatives. Application to the synthesis of coelenterazine.

  Organic letters 20090806

• Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone.

  Acta ophthalmologica 20090801

• Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women.

  Atherosclerosis 20090801

• Development and validation of an HPLC method to quantify 3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids.

  Biomedical chromatography : BMC 20090801

• Heat shock protein 27 modification is increased in the human diabetic failing heart.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090801

• Oxyanion and tetrahedral intermediate stabilisation by subtilisin: detection of a new tetrahedral adduct.

  Biochimica et biophysica acta 20090801

• Abstracts of the 2008 ISSOL Meeting. August 24-29, 2008. Florence, Italy.

  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20090801

• Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats.

  Journal of hypertension 20090801

• Cytotoxicity of Maillard reaction products determined with a peptide spot library.

  Molecular nutrition & food research 20090801

• Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli.

  Nature chemical biology 20090801

• Nephropathy and other topics.

  Diabetes care 20090801

• Salt stress-induced alterations in the root proteome of barley genotypes with contrasting response towards salinity.

  Journal of experimental botany 20090801

• Organocatalysis with endogenous compounds: towards novel non-enzymatic reactions.

  Bioorganic & medicinal chemistry letters 20090715

• Nickel-based Enzyme Systems.

  The Journal of biological chemistry 20090710

• A fluorescent probe for diacetyl detection.

  Journal of fluorescence 20090701

• Enhanced methylglyoxal formation in the erythrocytes of hemodialyzed patients.

  Metabolism: clinical and experimental 20090701

• Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies.

  Journal of hypertension 20090701

• EPHA2 is associated with age-related cortical cataract in mice and humans.

  PLoS genetics 20090701

• Determination of carbonyl compounds in beer by derivatisation and headspace solid-phase microextraction in combination with gas chromatography and mass spectrometry.

  Journal of chromatography. A 20090626

• Thermodynamics and kinetics of methylglyoxal dimer formation: a computational study.

  The journal of physical chemistry. A 20090625

• KTN (RCK) domains regulate K+ channels and transporters by controlling the dimer-hinge conformation.

  Structure (London, England : 1993) 20090610

• Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in sarcoma-180 bearing mice: involvement of MAP kinase, NF-kappa beta signal transduction pathway.

  Molecular immunology 20090601

• Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells.

  Biochemical pharmacology 20090601

• Characterization and the possible formation mechanism of 2-acetyl-1-pyrroline in aromatic vegetable soybean (Glycine max L.).

  Journal of food science 20090601

• The origin of methylglyoxal in New Zealand manuka (Leptospermum scoparium) honey.

  Carbohydrate research 20090526

• Yields of carbonyl products from gas-phase reactions of fragrance compounds with OH radical and ozone.

  Environmental science & technology 20090515

• Plasma advanced glycation endproduct, methylglyoxal-derived hydroimidazolone is elevated in young, complication-free patients with Type 1 diabetes.

  Clinical biochemistry 20090501

• Specific local cardiovascular changes of Nepsilon-(carboxymethyl)lysine, vascular endothelial growth factor, and Smad2 in the developing embryos coincide with maternal diabetes-induced congenital heart defects.

  Diabetes 20090501

• Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB.

  Molecular and cellular biochemistry 20090501

• Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

  Brain : a journal of neurology 20090501

• Formation of styrene during the Maillard reaction is negligible.

  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090501

• Methylglyoxal, protein binding and biological samples: are we getting the true measure?

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415

• Dicarbonyl-induced accelerated aging in vitro in human skin fibroblasts.

  Biogerontology 20090401

• Inhibition of human muscle-specific enolase by methylglyoxal and irreversible formation of advanced glycation end products.

  Journal of enzyme inhibition and medicinal chemistry 20090401

• Collagen cross-links reduce corneal permeability.

  Investigative ophthalmology & visual science 20090401

• Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats.

  American journal of physiology. Renal physiology 20090401

• 7-O-galloyl-D-sedoheptulose is a novel therapeutic agent against oxidative stress and advanced glycation endproducts in the diabetic kidney.

  Biological & pharmaceutical bulletin 20090401

• Superoxide formation as a result of interaction of L-lysine with dicarbonyl compounds and its possible mechanism.

  Biochemistry. Biokhimiia 20090401

• Impact of methylglyoxal and high glucose co-treatment on human mononuclear cells.

  International journal of molecular sciences 20090401

• Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress.

  Chemico-biological interactions 20090316

• Fructose and carbonyl metabolites as endogenous toxins.

  Chemico-biological interactions 20090316

• Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes.

  Chemico-biological interactions 20090316

• N-Terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation.

  Bioorganic & medicinal chemistry 20090315

• Effect of relative humidity on gas/particle partitioning and aerosol mass yield in the photooxidation of p-xylene.

  Environmental science & technology 20090315

• New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.

  Journal of medicinal chemistry 20090312

• Ultra performance liquid chromatography-mass spectrometric determination of the site specificity of modification of beta-casein by glucose and methylglyoxal.

  Amino acids 20090301

• The modification of alpha-synuclein by dicarbonyl compounds inhibits its fibril-forming process.

  Biochimica et biophysica acta 20090301

• Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease.

  Journal of ocular biology, diseases, and informatics 20090301

• Methylglyoxal induces peritoneal thickening by mesenchymal-like mesothelial cells in rats.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090201

• High-performance liquid chromatographic determination of creatine kinase activity influenced by methylglyoxal.

  Biomedical chromatography : BMC 20090201

• The influence of disinfection on aquatic biodegradable organic carbon formation.

  Water research 20090201

• Role of cysteine residues in the enhancement of chaperone function in methylglyoxal-modified human alpha A-crystallin.

  Molecular and cellular biochemistry 20090201

• Reaction mechanism of the binuclear zinc enzyme glyoxalase II - A theoretical study.

  Journal of inorganic biochemistry 20090201

• Phosphatidylserine decarboxylases, key enzymes of lipid metabolism.

  IUBMB life 20090201

• Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).

  Molecular microbiology 20090201

• Methylglyoxal inhibits smooth muscle contraction in isolated blood vessels.

  Journal of pharmacological sciences 20090201

• Dicarbonyl products of the OH radical-initiated reaction of a series of aromatic hydrocarbons.

  Environmental science & technology 20090201

• A glutathione-specific aldose reductase of Leishmania donovani and its potential implications for methylglyoxal detoxification pathway.

  Gene 20090115

• The formation of argpyrimidine, a methylglyoxal-arginine adduct, in the nucleus of neural cells.

  Biochemical and biophysical research communications 20090109

• Primary atmospheric oxidation mechanism for toluene.

  The journal of physical chemistry. A 20090108

• Exogenous collagen cross-linking reduces scleral permeability: modeling the effects of age-related cross-link accumulation.

  Investigative ophthalmology & visual science 20090101

• A fluorometric high-performance liquid chromatography procedure for simultaneous determination of methylamine and aminoacetone in blood and tissues.

  Analytical biochemistry 20090101

• Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes.

  Molecular and biochemical parasitology 20090101

• A novel mechanism of methylglyoxal cytotoxicity in neuroglial cells.

  Journal of neurochemistry 20090101

• A comparative study of methylglyoxal metabolism in trypanosomatids.

  The FEBS journal 20090101

• [methylglyoxal-induced superoxide anion production in endothelial cells].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090101

• Autothermal catalytic partial oxidation of glycerol to syngas and to non-equilibrium products.

  ChemSusChem 20090101

• Alteration of renal respiratory Complex-III during experimental type-1 diabetes.

  BMC endocrine disorders 20090101

• N(epsilon)-(Carboxymethyl)lysine and Coronary Atherosclerosis-Associated Low Density Lipoprotein Abnormalities in Type 2 Diabetes: Current Status.

  Journal of clinical biochemistry and nutrition 20090101

• Deamidation alters interactions of beta-crystallins in hetero-oligomers.

  Molecular vision 20090101

• Effect of glucose degradation products, glucose-containing dialysate and icodextrin on AQP1 and eNOS expression in cultured endothelial cells.

  Journal of nephrology 20090101

• A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior.

  PloS one 20090101

• Biological effects of electrolyzed water in hemodialysis.

  Nephron. Clinical practice 20090101

• CYP17, GSTP1, PON1 and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case-control study.

  BMC cancer 20090101

• Postprandial hyperglycemia as an etiological factor in vascular failure.

  Cardiovascular diabetology 20090101

• Azathioprine favourably influences the course of malaria.

  Malaria journal 20090101

• NAD+ availability and proteotoxicity.

  Neuromolecular medicine 20090101

• Carnosine and its possible roles in nutrition and health.

  Advances in food and nutrition research 20090101

• Independent inactivation of arginine decarboxylase genes by nonsense and missense mutations led to pseudogene formation in Chlamydia trachomatis serovar L2 and D strains.

  BMC evolutionary biology 20090101

• Association between carotid diameter and the advanced glycation end product N-epsilon-carboxymethyllysine (CML).

  Cardiovascular diabetology 20090101

• Advanced glycation of the Arg-Gly-Asp (RGD) tripeptide motif modulates retinal microvascular endothelial cell dysfunction.

  Molecular vision 20090101

• Genome-wide screen of genes required for caffeine tolerance in fission yeast.

  PloS one 20090101

• Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification.

  PloS one 20090101

• Sugar metabolism, redox balance and oxidative stress response in the respiratory yeast Kluyveromyces lactis.

  Microbial cell factories 20090101

• The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey.

  BMC complementary and alternative medicine 20090101

• The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria.

  PloS one 20090101

• Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study.

  PloS one 20090101

• [Progress in fundamental research: perspectives of cardiology].

  Terapevticheskii arkhiv 20090101

• Cellulosic hydrolysate toxicity and tolerance mechanisms in Escherichia coli.

  Biotechnology for biofuels 20090101

• Urea transport across peritoneal membrane in vitro: influence of protamine sulfate, glyoxal, and methylglyoxal.

  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20090101

• Initial activation of EpCAM cleavage via cell-to-cell contact.

  BMC cancer 20090101

• OXavidin for tissue targeting biotinylated therapeutics.

  Journal of biomedicine & biotechnology 20090101

• Methylglyoxal-derivative advanced glycation endproducts: detection by competitive immunofluorometric assay and quantifying in serum and urine.

  Clinical laboratory 20090101

• Determination of oxidative stress markers and their importance in early diagnosis of uremia-related complications.

  Indian journal of nephrology 20090101

• Oxidative stress and anxiety: relationship and cellular pathways.

  Oxidative medicine and cellular longevity 20090101

• Thermochemistry and kinetics of acetonylperoxy radical isomerisation and decomposition: a quantum chemistry and CVT/SCT approach.

  Physical chemistry chemical physics : PCCP 20081221

• Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase.

  Biochemistry 20081216

• Protein glycation in vivo: functional and structural effects on yeast enolase.

  The Biochemical journal 20081215

• Leptin decreases postprandially in people with type 2 diabetes, an effect reduced by the cooking method.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081201

• Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells.

  American journal of physiology. Cell physiology 20081201

• Degradation of tert-butyl formate and its intermediates by an ozone/UV process.

  Chemosphere 20081201

• Methylglyoxal accumulation by glutathione depletion leads to cell cycle arrest in Dictyostelium.

  Molecular microbiology 20081201

• Alteration in glycerol and metalloid permeability by a single mutation in the extracellular C-loop of Leishmania major aquaglyceroporin LmAQP1.

  Molecular microbiology 20081201

• The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast.

  PLoS genetics 20081201

• Sensitivity modeling study for an ozone occurrence during the 1996 Paso Del Norte Ozone Campaign.

  International journal of environmental research and public health 20081201

• 4-Acetyl-3,3-diethyl-5-hydr-oxy-2-morpholino-2,3-dihydro-1-benzofuran.

  Acta crystallographica. Section E, Structure reports online 20081201

• Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: methylglyoxal attenuates protein synthesis through phosphorylation of eIF2alpha.

  Biochemical and biophysical research communications 20081128

• Modulation of methylglyoxal and glutathione by soybean isoflavones in mild streptozotocin-induced diabetic rats.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20081101

• Activation of macrophages and lymphocytes by methylglyoxal against tumor cells in the host.

  International immunopharmacology 20081101

• Lymphocytes of type 2 diabetic women carry a high load of stable chromosomal aberrations: a novel risk factor for disease-related early death.

  Diabetes 20081101

• Inhibitory effect of vanillic acid on methylglyoxal-mediated glycation in apoptotic Neuro-2A cells.

  Neurotoxicology 20081101

• In vitro nonenzymatic glycation of guanosine 5'-triphosphate by dihydroxyacetone phosphate.

  Analytical and bioanalytical chemistry 20081101

• Advanced glycation end products of DNA: quantification of N2-(1-Carboxyethyl)-2'-deoxyguanosine in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry.

  Chemical research in toxicology 20081101

• Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation.

  Journal of neural transmission (Vienna, Austria : 1996) 20081101

• Advanced glycation of type I collagen and fibronectin modifies periodontal cell behavior.

  Journal of periodontology 20081101

• Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques.

  PLoS neglected tropical diseases 20081101

• Glyoxalase pathway of trypanosomatid parasites: a promising chemotherapeutic target.

  Current drug targets 20081101

• Atmospheric chemistry of acetylacetone.

  Environmental science & technology 20081101

• Enhanced production of 1,2-propanediol by tpi1 deletion in Saccharomyces cerevisiae.

  Journal of microbiology and biotechnology 20081101

• Polymorphonuclear leukocyte injury by methylglyoxal and hydrogen peroxide: a possible pathological role for enhanced oxidative stress in chronic kidney disease.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081001

• RAGE expression in the human peritoneal membrane.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081001

• Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.

  Diabetes 20081001

• Surface chemistry reactions of alpha-terpineol [(R)-2-(4-methyl-3-cyclohexenyl)isopropanol] with ozone and air on a glass and a vinyl tile.

  Indoor air 20081001

• Erythrocyte programmed cell death.

  IUBMB life 20081001

• Apple polyphenols, phloretin and phloridzin: new trapping agents of reactive dicarbonyl species.

  Chemical research in toxicology 20081001

• Expression of Xhdsi-1VOC, a novel member of the vicinal oxygen chelate (VOC) metalloenzyme superfamily, is up-regulated in leaves and roots during desiccation in the resurrection plant Xerophyta humilis (Bak) Dur and Schinz.

  Journal of experimental botany 20081001

• Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress.

  Biochemical Society transactions 20081001

• Protein glycation inhibitors from the fruiting body of Phellinus linteus.

  Biological & pharmaceutical bulletin 20081001

• [Methylglyoxal-induced apoptosis of endothelial cells].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20081001

• Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20081001

• International Diabetes Federation guideline for management of postmeal glucose: a review of recommendations.

  Diabetic medicine : a journal of the British Diabetic Association 20081001

• 3-Eth-oxy-4-hydroxy-benzaldehyde.

  Acta crystallographica. Section E, Structure reports online 20081001

• Antioxidant properties of argpyrimidine.

  European journal of pharmacology 20080928

• Crenarchaeal arginine decarboxylase evolved from an S-adenosylmethionine decarboxylase enzyme.

  The Journal of biological chemistry 20080919

• Capillary gas chromatographic determination of methylglyoxal from serum of diabetic patients by precolumn derivatization with 1,2-diamonopropane.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080915

• A novel derivatization approach for simultaneous determination of glyoxal, methylglyoxal, and 3-deoxyglucosone in plasma by gas chromatography-mass spectrometry.

  Journal of chromatography. A 20080912

• Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy.

  Diabetes 20080901

• Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors.

  Biochemical pharmacology 20080901

• Methylglyoxal production in vascular smooth muscle cells from different metabolic precursors.

  Metabolism: clinical and experimental 20080901

• Aminoacetone, a putative endogenous source of methylglyoxal, causes oxidative stress and death to insulin-producing RINm5f cells.

  Chemical research in toxicology 20080901

• Modulation of insulin action by advanced glycation endproducts: a new player in the field.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20080901

• Formation of 2,5-dimethyl-4-hydroxy-3(2H)-furanone through methylglyoxal: a Maillard reaction intermediate.

  Journal of agricultural and food chemistry 20080827

• Biosynthetic mechanism of 2-acetyl-1-pyrroline and its relationship with Delta1-pyrroline-5-carboxylic acid and methylglyoxal in aromatic rice (Oryza sativa L.) callus.

  Journal of agricultural and food chemistry 20080827

• Telmisartan inhibits methylglyoxal-mediated cell death in human vascular endothelium.

  Biochemical and biophysical research communications 20080822

• Analysis of a 30 kbp plasmid encoding histidine decarboxylase gene in Tetragenococcus halophilus isolated from fish sauce.

  International journal of food microbiology 20080815

• Reagentless amperometric formaldehyde-selective biosensors based on the recombinant yeast formaldehyde dehydrogenase.

  Talanta 20080815

• A practical alternative to chemiluminescence-based detection of nitrogen dioxide: cavity attenuated phase shift spectroscopy.

  Environmental science & technology 20080815

• Identification and monitoring of intermediates and products in the acrylamide pathway using online analysis.

  Journal of agricultural and food chemistry 20080813

• Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells.

  Molecular nutrition & food research 20080801

• A novel nutraceutical property of select sorghum (Sorghum bicolor) brans: inhibition of protein glycation.

  Phytotherapy research : PTR 20080801

• Use of capillary electrophoresis to evaluate protective effects of methylglyoxal scavengers on the activity of creatine kinase.

  Journal of separation science 20080801

• Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms.

  Current genomics 20080801

• Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures.

  Biochemistry 20080722

• Chemical modulation of the chaperone function of human alphaA-crystallin.

  Journal of biochemistry 20080701

• Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures.

  Extremophiles : life under extreme conditions 20080701

• Capillary gas chromatographic determination of methylglyoxal from serum of diabetic patients by precolumn derivatization using meso-stilbenediamine as derivatizing reagent.

  Journal of chromatographic science 20080701

• Feasibility of detection and quantification of gas-phase carbonyls in indoor environments using PFBHA derivatization and solid-phase microextraction (SPME).

  Journal of environmental monitoring : JEM 20080701

• Dietary soy isoflavones increase insulin secretion and prevent the development of diabetic cataracts in streptozotocin-induced diabetic rats.

  Nutrition research (New York, N.Y.) 20080701

• Reduced expression of glyoxalase-1 mRNA in mood disorder patients.

  Neuroscience letters 20080620

• Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases.

  Amino acids 20080601

• Binding of lipoic acid induces conformational change and appearance of a new binding site in methylglyoxal modified serum albumin.

  The protein journal 20080601

• Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I.

  Diabetologia 20080601

• Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification.

  Journal of experimental botany 20080601

• Formate excretion in urine of rats fed dimethylaminoazobenzene-rich diets: the possibility of formate formation from D-lactate.

  Acta medica Okayama 20080601

• Neurodegenerative diseases of the retina and potential for protection and recovery.

  Current neuropharmacology 20080601

• Proline and glycinebetaine enhance antioxidant defense and methylglyoxal detoxification systems and reduce NaCl-induced damage in cultured tobacco cells.

  Journal of plant physiology 20080526

• Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE)-mediated inhibition of endothelial nitric oxide synthase through RAGE activation.

  Clinical journal of the American Society of Nephrology : CJASN 20080501

• Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity.

  The Journal of pharmacology and experimental therapeutics 20080501

• Methylglyoxal increase in uremia with special reference to snakebite-mediated acute renal failure.

  Clinica chimica acta; international journal of clinical chemistry 20080501

• Renal toxicity mediated by glucose degradation products in a rat model of advanced renal failure.

  European journal of clinical investigation 20080501

• Bis(guanylhydrazones) negatively affect in vitro germination of kiwifruit pollen and alter the endogenous polyamine pool.

  Plant biology (Stuttgart, Germany) 20080501

• Structure of isochorismate synthase in complex with magnesium.

  Acta crystallographica. Section D, Biological crystallography 20080501

• The anticonvulsant activity of acetone does not depend upon its metabolites.

  Epilepsia 20080501

• Caffeine induces cell death via activation of apoptotic signal and inactivation of survival signal in human osteoblasts.

  International journal of molecular sciences 20080501

• Biochemical origins of lactaldehyde and hydroxyacetone in Methanocaldococcus jannaschii.

  Biochemistry 20080429

• Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.

  The Journal of biological chemistry 20080418

• The role of methylglyoxal in the non-enzymatic conversion of tryptophan, its methyl ester and tryptamine to 1-acetyl-beta-carbolines.

  Bioorganic & medicinal chemistry 20080415

• Thermal stability of carbonyl radicals. Part II. Reactions of methylglyoxyl and methylglyoxylperoxy radicals at 1 bar in the temperature range 275-311 K.

  Physical chemistry chemical physics : PCCP 20080407

• Enhancing salt tolerance in a crop plant by overexpression of glyoxalase II.

  Transgenic research 20080401

• Methylglyoxal and methylglyoxal-arginine adducts do not directly inhibit endothelial nitric oxide synthase.

  Annals of the New York Academy of Sciences 20080401

• Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl/L-xylulose reductase.

  Annals of the New York Academy of Sciences 20080401

• Usefulness of antibodies for evaluating the biological significance of AGEs.

  Annals of the New York Academy of Sciences 20080401

• Growth of Bradyrhizobium sp. SEMIA 6144 in response to methylglyoxal: role of glutathione.

  Current microbiology 20080401

• Extracellular methylglyoxal toxicity in Saccharomyces cerevisiae: role of glucose and phosphate ions.

  Journal of applied microbiology 20080401

• Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand.

  Molecular nutrition & food research 20080401

• Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects.

  Bioorganic & medicinal chemistry 20080401

• Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.

  Journal of hypertension 20080401

• Rapid analysis of alpha-dicarbonyl compounds by laser desorption/ionization mass spectrometry using 9-(3,4-diaminophenyl)acridine (DAA) as a reactive matrix.

  Rapid communications in mass spectrometry : RCM 20080401

• Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii.

  Acta crystallographica. Section D, Biological crystallography 20080401

• Determination of N epsilon-(carboxymethyl)lysine in foods and related systems.

  Annals of the New York Academy of Sciences 20080401

• Methylglyoxal: its presence in beverages and potential scavengers.

  Annals of the New York Academy of Sciences 20080401

• The other side of the Maillard reaction.

  Annals of the New York Academy of Sciences 20080401

• The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease.

  Annals of the New York Academy of Sciences 20080401

• Isolation and partial characterization of four fluorophores formed by nonenzymatic browning of methylglyoxal and glutamine-derived ammonia.

  Annals of the New York Academy of Sciences 20080401

• Pathophysiological role of the glyoxalase system in renal hypoxic injury.

  Annals of the New York Academy of Sciences 20080401

• Dietary advanced glycation endproducts and oxidative stress: in vivo effects on endothelial function and adipokines.

  Annals of the New York Academy of Sciences 20080401

• Preparation of nucleotide advanced glycation endproducts--imidazopurinone adducts formed by glycation of deoxyguanosine with glyoxal and methylglyoxal.

  Annals of the New York Academy of Sciences 20080401

• Modification of vimentin: a general mechanism of nonenzymatic glycation in human skin.

  Annals of the New York Academy of Sciences 20080401

• Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts.

  Journal of agricultural and food chemistry 20080326

• Formation of pyrazines and a novel pyrrole in Maillard model systems of 1,3-dihydroxyacetone and 2-oxopropanal.

  Journal of agricultural and food chemistry 20080326

• Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody.

  Journal of immunological methods 20080320

• Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey.

  Carbohydrate research 20080317

• Modification of casein by the lipid oxidation product malondialdehyde.

  Journal of agricultural and food chemistry 20080312

• Methylglyoxal and high glucose co-treatment induces apoptosis or necrosis in human umbilical vein endothelial cells.

  Journal of cellular biochemistry 20080301

• Characterization of organosulfates from the photooxidation of isoprene and unsaturated fatty acids in ambient aerosol using liquid chromatography/(-) electrospray ionization mass spectrometry.

  Journal of mass spectrometry : JMS 20080301

• Analysis and biological relevance of advanced glycation end-products of DNA in eukaryotic cells.

  The FEBS journal 20080301

• Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.

  Aging cell 20080301

• Metabolism of halophilic archaea.

  Extremophiles : life under extreme conditions 20080301

• Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy.

  Investigative ophthalmology & visual science 20080301

• Different patterns of in vivo pro-oxidant states in a set of cancer- or aging-related genetic diseases.

  Free radical biology & medicine 20080215

• The tandem of free radicals and methylglyoxal.

  Chemico-biological interactions 20080215

• Methylglyoxal induces prostaglandin E2 production in rat mesangial cells.

  The Kobe journal of medical sciences 20080208

• Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?

  Biogerontology 20080201

• Effect of methylglyoxal modification on stress-induced aggregation of client proteins and their chaperoning by human alphaA-crystallin.

  The Biochemical journal 20080201

• Protein glycation and methylglyoxal metabolism in yeast: finding peptide needles in protein haystacks.

  FEMS yeast research 20080201

• Role of GldA in dihydroxyacetone and methylglyoxal metabolism of Escherichia coli K12.

  FEMS microbiology letters 20080201

• Antiglycation effect of gliclazide on in vitro AGE formation from glucose and methylglyoxal.

  Experimental biology and medicine (Maywood, N.J.) 20080201

• Innovative technologies: Transportation fuels on the table.

  Environmental health perspectives 20080201

• Protective effect of lipoic acid against methylglyoxal-induced oxidative stress in LLC-PK(1) cells.

  Journal of nutritional science and vitaminology 20080201

• Pyridoxamine protects proteins from functional damage by 3-deoxyglucosone: mechanism of action of pyridoxamine.

  Biochemistry 20080122

• Catalysis and structural properties of Leishmania infantum glyoxalase II: trypanothione specificity and phylogeny.

  Biochemistry 20080108

• Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons.

  The international journal of biochemistry & cell biology 20080101

• Effects of advanced glycation end product modification on proximal tubule epithelial cell processing of albumin.

  American journal of nephrology 20080101

• The structural modification of DNA nucleosides by nonenzymatic glycation: an in vitro study based on the reactions of glyoxal and methylglyoxal with 2'-deoxyguanosine.

  Analytical and bioanalytical chemistry 20080101

• AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.

  American journal of physiology. Cell physiology 20080101

• The implausibility of metabolic cycles on the prebiotic Earth.

  PLoS biology 20080101

• Methylglyoxal: its presence and potential scavengers.

  Asia Pacific journal of clinical nutrition 20080101

• Radiolabeling rhesus monkey CD34+ hematopoietic and mesenchymal stem cells with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for microPET imaging.

  Molecular imaging 20080101

• Distribution of glyoxalase I polymorphism among Zuni Indians: the Zuni Kidney Project.

  Journal of diabetes and its complications 20080101

• [Role of methyl glyoxal and glyoxalase in diabetes and tumor growth].

  Voprosy onkologii 20080101

• Special issue on methylglyoxal. Preface.

  Drug metabolism and drug interactions 20080101

• Molecular enzymology of the glyoxalase system.

  Drug metabolism and drug interactions 20080101

• Microbial glyoxalase enzymes: metalloenzymes controlling cellular levels of methylglyoxal.

  Drug metabolism and drug interactions 20080101

• An overview on the role of methylglyoxal and glyoxalases in plants.

  Drug metabolism and drug interactions 20080101

• Methylglyoxal and glucose metabolism: a historical perspective and future avenues for research.

  Drug metabolism and drug interactions 20080101

• Methylglyoxal, diabetes mellitus and diabetic complications.

  Drug metabolism and drug interactions 20080101

• Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease.

  Drug metabolism and drug interactions 20080101

• Free radical generation by methylglyoxal in tissues.

  Drug metabolism and drug interactions 20080101

• A brief critical overview of the biological effects of methylglyoxal and further evaluation of a methylglyoxal-based anticancer formulation in treating cancer patients.

  Drug metabolism and drug interactions 20080101

• Plasma alpha-oxoaldehyde levels in diabetic and nondiabetic chronic kidney disease patients.

  American journal of nephrology 20080101

• Identification of metabolites with anticancer properties by computational metabolomics.

  Molecular cancer 20080101

• Degradation of macromolecular tannic acid by O3/H2O2.

  Water science and technology : a journal of the International Association on Water Pollution Research 20080101

• Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes.

  BMC genetics 20080101

• Structure and properties of transcriptional networks driving selenite stress response in yeasts.

  BMC genomics 20080101

• Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

  PloS one 20080101

• Differential control of Zap1-regulated genes in response to zinc deficiency in Saccharomyces cerevisiae.

  BMC genomics 20080101

• High cell density media for Escherichia coli are generally designed for aerobic cultivations - consequences for large-scale bioprocesses and shake flask cultures.

  Microbial cell factories 20080101

• Morphology of glomerular hematuria is reproduced in vitro by carbonyl stress.

  Nephron. Experimental nephrology 20080101

• Gene expression profiling in hepatic tissue of newly weaned pigs fed pharmacological zinc and phytase supplemented diets.

  BMC genomics 20080101

• The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes.

  Cardiovascular diabetology 20080101

• A novel screening protocol for the isolation of hydrogen producing Chlamydomonas reinhardtii strains.

  BMC plant biology 20080101

• Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity.

  PloS one 20080101

• Hypometabolism as a therapeutic target in Alzheimer's disease.

  BMC neuroscience 20080101

• Experimental confirmation of the dicarbonyl route in the photo-oxidation of toluene and benzene.

  Environmental science & technology 20071215

• Isolation, identification, and quantification of roasted coffee antibacterial compounds.

  Journal of agricultural and food chemistry 20071212

• Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats.

  Molecular and cellular biochemistry 20071201

• High-performance liquid chromatographic determination of glyoxal and methylglyoxal in urine by prederivatization to lumazinic rings using in serial fast scan fluorimetric and diode array detectors.

  Analytical biochemistry 20071201

• Methylglyoxal and other carbohydrate metabolites induce lanthanum-sensitive Ca2+ transients and inhibit growth in E. coli.

  Archives of biochemistry and biophysics 20071201

• Tea polyphenol (-)-epigallocatechin-3-gallate: a new trapping agent of reactive dicarbonyl species.

  Chemical research in toxicology 20071201

• Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.

  Cancer research 20071201

• Mechanisms of epithelial-mesenchymal transition of peritoneal mesothelial cells during peritoneal dialysis.

  Journal of Korean medical science 20071201

• Current concepts in targeted therapies for the pathophysiology of diabetic microvascular complications.

  Vascular health and risk management 20071201

• Therapeutic options and challenges for substances of abuse.

  Dialogues in clinical neuroscience 20071201

• Alteration of glyoxalase genes expression in response to testosterone in LNCaP and PC3 human prostate cancer cells.

  Cancer biology & therapy 20071201

• Modulation of Spc1 stress-activated protein kinase activity by methylglyoxal through inhibition of protein phosphatase in the fission yeast Schizosaccharomyces pombe.

  Biochemical and biophysical research communications 20071130

• Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia.

  Journal of inherited metabolic disease 20071101

• Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes.

  Molecular and cellular biochemistry 20071101

• Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function.

  Kidney international 20071101

• Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus.

  Clinical biochemistry 20071101

• Determination of glyoxal and methylglyoxal in the serum of diabetic patients by MEKC using stilbenediamine as derivatizing reagent.

  Electrophoresis 20071101

• Glycation damage targets glutamate dehydrogenase in the rat liver mitochondrial matrix during aging.

  The FEBS journal 20071101

• DNA damage during glycation of lysine by methylglyoxal: assessment of vitamins in preventing damage.

  Amino acids 20071101

• Effect of solvent type on the degradation of 4-MET.

  Dental materials journal 20071101

• Isolation and determination of alpha-dicarbonyl compounds by RP-HPLC-DAD in green and roasted coffee.

  Journal of agricultural and food chemistry 20071031

• Determination of glyoxal and methylglyoxal in environmental and biological matrices by stir bar sorptive extraction with in-situ derivatization.

  Journal of chromatography. A 20071026

• High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.

  The Journal of biological chemistry 20071019

• Molecular action mechanism against apoptosis by aqueous extract from guava budding leaves elucidated with human umbilical vein endothelial cell (HUVEC) model.

  Journal of agricultural and food chemistry 20071017

• Evaluation of enhanced peritoneum permeability in methylglyoxal-treated rats as a diagnostic method for peritoneal damage.

  Pharmaceutical research 20071001

• Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071001

• Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice.

  American journal of physiology. Renal physiology 20071001

• Oxidative stress biomarkers in four Bloom syndrome (BS) patients and in their parents suggest in vivo redox abnormalities in BS phenotype.

  Clinical biochemistry 20071001

• Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray.

  Oncology reports 20071001

• Identification and determination of alpha-dicarbonyl compounds formed in the degradation of sugars.

  Bioscience, biotechnology, and biochemistry 20071001

• Mechanisms of oxidative modification of low density lipoproteins under conditions of oxidative and carbonyl stress.

  Biochemistry. Biokhimiia 20071001

• Allosteric coupling of two different functional active sites in monomeric Plasmodium falciparum glyoxalase I.

  The Journal of biological chemistry 20070928

• Direct observation of aminyl radical intermediate during single-crystal to single-crystal photoinduced Orton rearrangement.

  The journal of physical chemistry. B 20070906

• Prevention of oxidative damage that contributes to the loss of bioenergetic capacity in ageing skin.

  Experimental gerontology 20070901

• Enzymatic characteristics of an aldo-keto reductase family protein (AKR1C15) and its localization in rat tissues.

  Archives of biochemistry and biophysics 20070901

• Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

  The Journal of pharmacology and experimental therapeutics 20070901

• Evidence for in vivo scavenging by aminoguanidine of formaldehyde produced via semicarbazide-sensitive amine oxidase-mediated deamination.

  The Journal of pharmacology and experimental therapeutics 20070901

• The high-osmolarity glycerol response pathway in the human fungal pathogen Candida glabrata strain ATCC 2001 lacks a signaling branch that operates in baker's yeast.

  Eukaryotic cell 20070901

• Role of N-(carboxymethyl)lysine in the development of ischemic heart disease in type 2 diabetes mellitus.

  Journal of clinical biochemistry and nutrition 20070901

• A thermolyzed diet increases oxidative stress, plasma alpha-aldehydes and colonic inflammation in the rat.

  Chemico-biological interactions 20070830

• A combined experimental and theoretical study of the reaction between methylglyoxal and OH/OD radical: OH regeneration.

  Physical chemistry chemical physics : PCCP 20070821

• Methylglyoxal suppresses TNF-alpha-induced NF-kappaB activation by inhibiting NF-kappaB DNA-binding.

  Biochemical pharmacology 20070815

• Analysis of DNA-bound advanced glycation end-products by LC and mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070801

• Plasma protein advanced glycation end products, carboxymethyl cysteine, and carboxyethyl cysteine, are elevated and related to nephropathy in patients with diabetes.

  Molecular and cellular biochemistry 20070801

• Comparison of results of the CellTiter Blue, the tetrazolium (3-[4,5-dimethylthioazol-2-yl]-2,5-diphenyl tetrazolium bromide), and the lactate dehydrogenase assay applied in brain cells after exposure to advanced glycation endproducts.

  Toxicology in vitro : an international journal published in association with BIBRA 20070801

• Methylglyoxal-induced fibronectin gene expression through Ras-mediated NADPH oxidase activation in renal mesangial cells.

  Nephrology (Carlton, Vic.) 20070801

• Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis.

  Molecular microbiology 20070801

• Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling.

  Genes to cells : devoted to molecular & cellular mechanisms 20070801

• Screening of genes related to methylglyoxal susceptibility.

  Journal of microbiology (Seoul, Korea) 20070801

• Metal ion activation of S-adenosylmethionine decarboxylase reflects cation charge density.

  Biochemistry 20070710

• Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells--protection by carbonyl scavengers.

  Neurobiology of aging 20070701

• Free glutamine as a major precursor of brown products and fluorophores in Maillard reaction systems.

  Amino acids 20070701

• Alpha-oxoaldehydes in haemodialysis solution.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070701

• Reactive oxygen species as a signal in glucose-stimulated insulin secretion.

  Diabetes 20070701

• Isolation, purification and characterization of histidino-threosidine, a novel Maillard reaction protein crosslink from threose, lysine and histidine.

  Archives of biochemistry and biophysics 20070701

• Pyridine nucleotide redox abnormalities in diabetes.

  Antioxidants & redox signaling 20070701

• Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water.

  Hemodialysis international. International Symposium on Home Hemodialysis 20070701

• Delta1-pyrroline-5-carboxylic acid formed by proline dehydrogenase from the Bacillus subtilis ssp. natto expressed in Escherichia coli as a precursor for 2-acetyl-1-pyrroline.

  Journal of agricultural and food chemistry 20070627

• Evaluation of the contact and respiratory sensitization potential of volatile organic compounds generated by simulated indoor air chemistry.

  Toxicological sciences : an official journal of the Society of Toxicology 20070601

• Glutathione levels in blood from ataxia telangiectasia patients suggest in vivo adaptive mechanisms to oxidative stress.

  Clinical biochemistry 20070601

• L-Carnitine inhibits protein glycation in vitro and in vivo: evidence for a role in diabetic management.

  Acta diabetologica 20070601

• Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: role of methylglyoxal.

  American journal of hypertension 20070601

• Simultaneous determination of ketoacids and dicarbonyl compounds, key Maillard intermediates on the generation of aged wine aroma.

  Journal of food science 20070601

• Methylglyoxal and advanced glycation endproducts: new therapeutic horizons?

  Recent patents on cardiovascular drug discovery 20070601

• Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells.

  Biochemical and biophysical research communications 20070525

• Structure-reactivity relationships of flavan-3-ols on product generation in aqueous glucose/glycine model systems.

  Journal of agricultural and food chemistry 20070502

• Methylglyoxal inhibits glycation-mediated loss in chaperone function and synthesis of pentosidine in alpha-crystallin.

  Experimental eye research 20070501

• Advanced glycation endproducts: what is their relevance to diabetic complications?

  Diabetes, obesity & metabolism 20070501

• The conformation of acetylated virginiamycin M1 and virginiamycin M1 in explicit solvents.

  Biochimica et biophysica acta 20070501

• Methyl glyoxal elevation is associated with oxidative stress in rheumatoid arthritis.

  Free radical research 20070501

• Increase of intracellular methylglyoxal levels as a mode of action of retinoids against psoriasis.

  Dermatology online journal 20070501

• The involvement of lipid radical cycles and the adenine nucleotide translocator in neurodegenerative diseases.

  Journal of Alzheimer's disease : JAD 20070501

• Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts.

  European journal of pharmacology 20070430

• The effect of chemical modification of amino acid side-chains on collagen degradation by enzymes.

  Journal of biomedical materials research. Part B, Applied biomaterials 20070401

• Dietary restriction, glycolysis, hormesis and ageing.

  Biogerontology 20070401

• Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20070401

• The sugar model: autocatalytic activity of the triose-ammonia reaction.

  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20070401

• The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.

  Epilepsia 20070401

• Reducing the formation of glucose degradation products in peritoneal dialysis solutions by ultrahigh temperature ohmic heating.

  Molecular nutrition & food research 20070401

• Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20070401

• Aldehydes and disturbance of carbohydrate metabolism: some consequences and possible approaches to its normalization.

  Archives of physiology and biochemistry 20070401

• Complexes of atmospheric alpha-dicarbonyls with water: FTIR matrix isolation and theoretical study.

  The journal of physical chemistry. A 20070329

• 13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes.

  The Journal of biological chemistry 20070316

• Methylglyoxal inhibits the binding step of collagen phagocytosis.

  The Journal of biological chemistry 20070316

• Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation.

  The Journal of biological chemistry 20070309

• Synthesis of 1-piperideine-6-carboxylic acid produced by L-lysine-epsilon-aminotransferase from the Streptomyces clavuligerus gene expressed in Escherichia coli.

  Journal of agricultural and food chemistry 20070307

• Apoptotic signaling in methylglyoxal-treated human osteoblasts involves oxidative stress, c-Jun N-terminal kinase, caspase-3, and p21-activated kinase 2.

  Journal of cellular biochemistry 20070301

• Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme.

  Archives of biochemistry and biophysics 20070301

• The impact of glycation on apolipoprotein A-I structure and its ability to activate lecithin:cholesterol acyltransferase.

  Diabetologia 20070301

• Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages.

  The FEBS journal 20070301

• Advanced glycation endproduct induces ROS accumulation, apoptosis, MAP kinase activation and nuclear O-GlcNAcylation in human cardiac myocytes.

  Life sciences 20070220

• Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.

  Cell 20070209

• Changes in the volatile composition of a semihard ewe milk cheese induced by high-pressure treatment of 300 MPa.

  Journal of agricultural and food chemistry 20070207

• Convenient synthesis of GOLD and MOLD and identification of their oxidation products in vitro and in vivo.

  Amino acids 20070201

• Methylglyoxal-derived beta-carbolines formed from tryptophan and its derivates in the Maillard reaction.

  Amino acids 20070201

• Can ageing be prevented by dietary restriction?

  Mechanisms of ageing and development 20070201

• Icodextrin peritoneal transport in vitro: effect of sodium deoxycholate, glucose, and methylglyoxal.

  Artificial organs 20070201

• Proline organocatalysis as a new tool for the asymmetric synthesis of ulosonic acid precursors.

  Chemical communications (Cambridge, England) 20070107

• Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains.

  Neurobiology of aging 20070101

• The dual face of endogenous alpha-aminoketones: pro-oxidizing metabolic weapons.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070101

• Characterization and functional validation of glyoxalase II from rice.

  Protein expression and purification 20070101

• A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase.

  FEMS yeast research 20070101

• Detection and identification of arginine modifications on methylglyoxal-modified ribonuclease by mass spectrometric analysis.

  Journal of mass spectrometry : JMS 20070101

• Effects of high pressure treatment on volatile profile during ripening of ewe milk cheese.

  Journal of dairy science 20070101

• Agmatine transport into spinal nerve terminals is modulated by polyamine analogs.

  Journal of neurochemistry 20070101

• Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1.

  BMC medical genetics 20070101

• Impact of 3,4-dideoxyglucosone-3-ene (3,4-DGE) on cytotoxicity of acidic heat-sterilized peritoneal dialysis fluid.

  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 20070101

• Effect of aldehydes derived from oxidative deamination and oxidative stress on beta-amyloid aggregation; pathological implications to Alzheimer's disease.

  Journal of neural transmission (Vienna, Austria : 1996) 20070101

• Evaluation of toxicity of the mycotoxin citrinin using yeast ORF DNA microarray and Oligo DNA microarray.

  BMC genomics 20070101

• Selective prediction of interaction sites in protein structures with THEMATICS.

  BMC bioinformatics 20070101

• Beta-D-glucoside utilization by Mycoplasma mycoides subsp. mycoides SC: possible involvement in the control of cytotoxicity towards bovine lung cells.

  BMC microbiology 20070101

• AGEs and methylglyoxal induce apoptosis and expression of Mac-1 on neutrophils resulting in platelet-neutrophil aggregation.

  Thrombosis research 20070101

• Identification of regulatory network topological units coordinating the genome-wide transcriptional response to glucose in Escherichia coli.

  BMC microbiology 20070101

• Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage.

  Novartis Foundation symposium 20070101

• Radical generation by the non-enzymatic reaction of methylglyoxal and hydrogen peroxide.

  Redox report : communications in free radical research 20070101

• Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli.

  Molecular systems biology 20070101

• Oxidative stress and diabetic retinopathy.

  Experimental diabetes research 20070101

• Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes.

  Experimental diabetes research 20070101

• Glucosamine prevents in vitro collagen degradation in chondrocytes by inhibiting advanced lipoxidation reactions and protein oxidation.

  Arthritis research & therapy 20070101

• Role of advanced glycation end products in hypertension and atherosclerosis: therapeutic implications.

  Cell biochemistry and biophysics 20070101

• Factors affecting icodextrin peritoneal transport in vitro.

  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20070101

• Immunohistochemical study of N-epsilon-carboxymethyl lysine (CML) in human brain: relation to vascular dementia.

  BMC neurology 20070101

• Ras activation modulates methylglyoxal-induced mesangial cell apoptosis through superoxide production.

  Renal failure 20070101

• Genome-wide interacting effects of sucrose and herbicide-mediated stress in Arabidopsis thaliana: novel insights into atrazine toxicity and sucrose-induced tolerance.

  BMC genomics 20070101

• Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress.

  Journal of biology 20070101

• Advanced glycation: a novel outlook on atherosclerosis.

  Current pharmaceutical design 20070101

• Cellular signaling and potential new treatment targets in diabetic retinopathy.

  Experimental diabetes research 20070101

• [Crystalline silica can induce oxidative stress by inhibiting glyoxalase system in bronchial epithelial cells].

  Giornale italiano di medicina del lavoro ed ergonomia 20070101

• The role of glucose metabolism and glucose-associated signalling in cancer.

  Perspectives in medicinal chemistry 20070101

• Investigations on the promoting effect of ammonium hydrogencarbonate on the formation of acrylamide in model systems.

  Journal of agricultural and food chemistry 20061227

• Site-selective modifications of arginine residues in human hemoglobin induced by methylglyoxal.

  Biochemistry 20061226

• Heterogeneous reactions of methylglyoxal in acidic media: implications for secondary organic aerosol formation.

  Environmental science & technology 20061215

• Trypanothione-dependent glyoxalase I in Trypanosoma cruzi.

  The Biochemical journal 20061201

• Oxidation of acetylacetone catalyzed by horseradish peroxidase in the absence of hydrogen peroxide.

  Biochimica et biophysica acta 20061201

• Yeast protein glycation in vivo by methylglyoxal. Molecular modification of glycolytic enzymes and heat shock proteins.

  The FEBS journal 20061201

• Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis.

  Journal of neurochemistry 20061201

• Methylglyoxal in food and living organisms.

  Molecular nutrition & food research 20061201

• Trapping reactions of reactive carbonyl species with tea polyphenols in simulated physiological conditions.

  Molecular nutrition & food research 20061201

• Suppression of AGE precursor formation following unilateral ureteral obstruction in mouse kidneys by transgenic expression of alpha-dicarbonyl/L-xylulose reductase.

  Bioscience, biotechnology, and biochemistry 20061201

• Methylglyoxal, oxidative stress, and hypertension.

  Canadian journal of physiology and pharmacology 20061201

• Fructose-induced peroxynitrite production is mediated by methylglyoxal in vascular smooth muscle cells.

  Life sciences 20061125

• Alpha,beta-dicarbonyl reduction by Saccharomyces D-arabinose dehydrogenase.

  Biochimica et biophysica acta 20061101

• Use of solid-phase microextraction to detect and quantify gas-phase dicarbonyls in indoor environments.

  Journal of chromatography. A 20061027

• Oligomer formation in evaporating aqueous glyoxal and methyl glyoxal solutions.

  Environmental science & technology 20061015

• Outside-in trimming of humic substances during ozonation in a membrane contactor.

  Environmental science & technology 20061015

• Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.

  Biochemistry 20061010

• Methylglyoxal bypass identified as source of chiral contamination in l(+) and d(-)-lactate fermentations by recombinant Escherichia coli.

  Biotechnology letters 20061001

• Towards the control and inhibition of glycation-the role of the guanidine reaction center with aldehydic and diketonic dicarbonyls. A mass spectrometry study.

  Journal of mass spectrometry : JMS 20061001

• Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis.

  Cancer letters 20060928

• Epicatechin carbonyl-trapping reactions in aqueous maillard systems: Identification and structural elucidation.

  Journal of agricultural and food chemistry 20060920

• Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.

  The Journal of biological chemistry 20060908

• Cumene peroxide and Fe(2+)-ascorbate-induced lipid peroxidation and effect of phosphoglucose isomerase.

  Molecular and cellular biochemistry 20060901

• Effect of methylglyoxal modification and phosphorylation on the chaperone and anti-apoptotic properties of heat shock protein 27.

  Journal of cellular biochemistry 20060901

• Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols.

  The Biochemical journal 20060901

• Protective effects of curcumin on methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells.

  Acta pharmacologica Sinica 20060901

• Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.

  Diabetes care 20060901

• Gene expression changes related to endocrine function and decline in reproduction in fathead minnow (Pimephales promelas) after dietary methylmercury exposure.

  Environmental health perspectives 20060901

• Protein modification in aging: an update.

  Experimental gerontology 20060901

• Characterization of the glyoxalase I gene from the vascular wilt fungus Verticillium dahliae.

  Canadian journal of microbiology 20060901

• Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanisms.

  Vascular health and risk management 20060901

• Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation.

  Biochimica et biophysica acta 20060801

• Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses.

  Molecular and cellular biochemistry 20060801

• Multiple evidence for an early age pro-oxidant state in Down Syndrome patients.

  Biogerontology 20060801

• Antibodies and Fab fragments protect Cu,Zn-SOD against methylglyoxal-induced inactivation.

  Biochimica et biophysica acta 20060801

• Carbonyl emissions from commercial cooking sources in Hong Kong.

  Journal of the Air & Waste Management Association (1995) 20060801

• Concentrations and source characteristics of airborne carbonyl compounds measured outside urban residences.

  Journal of the Air & Waste Management Association (1995) 20060801

• Structural and functional changes in human insulin induced by methylglyoxal.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060701

• Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification.

  Diabetes 20060701

• Methylglyoxal detoxification by an aldo-keto reductase in the cyanobacterium Synechococcus sp. PCC 7002.

  Microbiology (Reading, England) 20060701

• Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.

  Biochemistry 20060627

• Synthesis and study of controlled release of ibuprofen from the new acrylic type polymers.

  International journal of pharmaceutics 20060619

• Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells.

  Journal of neuroscience research 20060601

• Non-enzymatic model glycation reactions--a comprehensive study of the reactivity of a modified arginine with aldehydic and diketonic dicarbonyl compounds by electrospray mass spectrometry.

  Journal of mass spectrometry : JMS 20060601

• A novel erythrocyte-based immunoassay for simultaneous detection of both antimycobacterial antibody response and mycobacterial antigen in human serum samples of pulmonary tuberculosis and a control group of patients using 'a single probe'.

  FEMS immunology and medical microbiology 20060601

• Mechanism of the OH-initiated oxidation of hydroxyacetone over the temperature range 236-298 K.

  The journal of physical chemistry. A 20060601

• Oxidative modification of human ceruloplasmin by methylglyoxal: an in vitro study.

  Journal of biochemistry and molecular biology 20060531

• Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species.

  Diabetes 20060501

• Does chronic glycolysis accelerate aging? Could this explain how dietary restriction works?

  Annals of the New York Academy of Sciences 20060501

• Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions.

  The Journal of biological chemistry 20060428

• Analytical methods for trace levels of reactive carbonyl compounds formed in lipid peroxidation systems.

  Journal of pharmaceutical and biomedical analysis 20060411

• Effect of site-directed mutagenesis of methylglyoxal-modifiable arginine residues on the structure and chaperone function of human alphaA-crystallin.

  Biochemistry 20060411

• Methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast Schizosaccharomyces pombe.

  The Journal of biological chemistry 20060407

• In vivo assessment of toxicity and pharmacokinetics of methylglyoxal. Augmentation of the curative effect of methylglyoxal on cancer-bearing mice by ascorbic acid and creatine.

  Toxicology and applied pharmacology 20060401

• Hydrazine compounds inhibit glycation of low-density lipoproteins and prevent the in vitro formation of model foam cells from glycolaldehyde-modified low-density lipoproteins.

  Diabetologia 20060401

• A sensitive method for the quantification of acrolein and other volatile carbonyls in ambient air.

  Analytical chemistry 20060401

• Elevated level of methylglyoxal during diabetic ketoacidosis and its recovery phase.

  Diabetes & metabolism 20060401

• Hydroxyalkylation of conjugated nitroalkenes with activated nonenolizable carbonyl compounds.

  Organic letters 20060316

• Stimulation of insulin release by glyceraldehyde may not be similar to glucose.

  Archives of biochemistry and biophysics 20060315

• Formation of amines and aldehydes from parent amino acids during thermal processing of cocoa and model systems: new insights into pathways of the strecker reaction.

  Journal of agricultural and food chemistry 20060308

• Heat-shock protein 27 is a major methylglyoxal-modified protein in endothelial cells.

  FEBS letters 20060306

• A possible regulatory role of 17beta-estradiol and tamoxifen on glyoxalase I and glyoxalase II genes expression in MCF7 and BT20 human breast cancer cells.

  Breast cancer research and treatment 20060301

• The fate of glyoxal and methylglyoxal in peritoneal dialysis.

  Journal of mass spectrometry : JMS 20060301

• Inhibition of apoptosis and reduction of intracellular pH decrease in retinal neural cell cultures by a blocker of carbonic anhydrase.

  Investigative ophthalmology & visual science 20060301

• Carbonyl stress and NMDA receptor activation contribute to methylglyoxal neurotoxicity.

  Free radical biology & medicine 20060301

• The sour side of sweet.

  Science of aging knowledge environment : SAGE KE 20060208

• Antimelanoma activity of apoptogenic carbonyl scavengers.

  The Journal of pharmacology and experimental therapeutics 20060201

• Transgenic tobacco overexpressing glyoxalase pathway enzymes grow and set viable seeds in zinc-spiked soils.

  Plant physiology 20060201

• Reactions of a modified lysine with aldehydic and diketonic dicarbonyl compounds: an electrospray mass spectrometry structure/activity study.

  Journal of mass spectrometry : JMS 20060201

• Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme.

  Molecular microbiology 20060201

• Interaction of Nepsilon(carboxymethyl)lysine- and methylglyoxal-modified albumin with endothelial cells and macrophages. Splice variants of RAGE may limit the responsiveness of human endothelial cells to AGEs.

  Thrombosis and haemostasis 20060201

• Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.

  Cell 20060127

• Methylglyoxal comes of AGE.

  Cell 20060127

• Reaction of HO with hydroxyacetone (HOCH2C(O)CH3): rate coefficients (233-363 K) and mechanism.

  Physical chemistry chemical physics : PCCP 20060114

• Glycation increases human annulus fibrosus stiffness in both experimental measurements and theoretical predictions.

  Journal of biomechanics 20060101

• Characterization of the gene encoding glyoxalase II from Leishmania donovani: a potential target for anti-parasite drugs.

  The Biochemical journal 20060101

• Gender-related differences in advanced glycation endproducts, oxidative stress markers and nitric oxide synthases in rats.

  Kidney international 20060101

• Identification of 4-oxo-2-hexenal and other direct mutagens formed in model lipid peroxidation reactions as dGuo adducts.

  Chemical research in toxicology 20060101

• Time course of specific AGEs during optimised glycaemic control in type 2 diabetes.

  The Netherlands journal of medicine 20060101

• Methylglyoxal downregulates Raf-1 protein through a ubiquitination-mediated mechanism.

  The international journal of biochemistry & cell biology 20060101

• Novel electrochemical approach to enhanced toxicity of 4-oxo-2-nonenal vs. 4-hydroxy-2-nonenal (role of imine): oxidative stress and therapeutic modalities.

  Medical hypotheses 20060101

• Glucose degradation products and the peritoneum--how sweet things can turn bitter.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20060101

• Peritoneal injury by methylglyoxal in peritoneal dialysis.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20060101

• Further testing of antiviral activity of methylglyoxal urgently needed.

  Medical hypotheses 20060101

• Overexpression of glyoxalase system enzymes in human kidney tumor.

  Cancer journal (Sudbury, Mass.) 20060101

• [Oxidative stress and protein glycation in diabetes mellitus].

  Annales de biologie clinique 20060101

• Is methylglyoxal a causative factor for hypertension development?

  Canadian journal of physiology and pharmacology 20060101

• Unmeasured anions in metabolic acidosis: unravelling the mystery.

  Critical care (London, England) 20060101

• Pyridoxamine inhibits maillard reactions in diabetic rat lenses.

  Ophthalmic research 20060101

• Stimulation of suicidal erythrocyte death by methylglyoxal.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• Critical role of methylglyoxal and AGE in mycobacteria-induced macrophage apoptosis and activation.

  PloS one 20060101

• Relationships of Cysteine and Lysine residues with the substrate binding site of the mitochondrial ornithine/citrulline carrier: an inhibition kinetic approach combined with the analysis of the homology structural model.

  Biochimica et biophysica acta 20051210

• Curcumin prevents methylglyoxal-induced oxidative stress and apoptosis in mouse embryonic stem cells and blastocysts.

  Journal of cellular physiology 20051201

• Protein arginine methyltransferases: guardians of the Arg?

  Trends in biochemical sciences 20051201

• Hyperglycemia potentiates carbonyl stress-induced apoptosis in naïve PC-12 cells: relationship to cellular redox and activator protease factor-1 expression.

  Current neurovascular research 20051201

• Methylglyoxal levels in plants under salinity stress are dependent on glyoxalase I and glutathione.

  Biochemical and biophysical research communications 20051111

• Transgenic tobacco plants overexpressing glyoxalase enzymes resist an increase in methylglyoxal and maintain higher reduced glutathione levels under salinity stress.

  FEBS letters 20051107

• The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe.

  The Journal of biological chemistry 20051104

• Characterization of advanced glycation end products: mass changes in correlation to side chain modifications.

  Analytical biochemistry 20051101

• Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress.

  Diabetes 20051101

• [New aspects of diabetes].

  Annales pharmaceutiques francaises 20051101

• Isolation of mutagenic beta-carboline derivatives after nitrite treatment of maillard reaction mixtures and analysis of these compounds from foodstuffs and human urine.

  Bioscience, biotechnology, and biochemistry 20051101

• Mycobacterial mutants with defective control of phagosomal acidification.

  PLoS pathogens 20051101

• A new role of phosphoglucose isomerase. Involvement of the glycolytic enzyme in aldehyde metabolism.

  Biochemistry. Biokhimiia 20051101

• The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of alpha-oxoaldehyde plasma protein adducts in Fischer 344 rats.

  FEBS letters 20051024

• Glycated and oxidized protein degradation products are indicators of fasting and postprandial hyperglycemia in diabetes.

  Diabetes care 20051001

• Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy.

  Diabetes 20051001

• Simultaneous determination of mono- and dicarboxylic acids, omega-Oxo-carboxylic acids, midchain ketocarboxylic acids, and aldehydes in atmospheric aerosol samples.

  Environmental science & technology 20051001

• Identification of DNA adducts of methylglyoxal.

  Chemical research in toxicology 20051001

• A novel HPLC procedure for detection and quantification of aminoacetone, a precursor of methylglyoxal, in biological samples.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

• Gas-phase chemistry of (alpha-terpineol with ozone and OH radical: rate constants and products.

  Environmental science & technology 20050915

• Reaction coordinate analysis for beta-diketone cleavage by the non-heme Fe2+-dependent dioxygenase Dke1.

  Journal of the American Chemical Society 20050907

• Regioselective N-functionalization of tetraazacycloalkanes.

  The Journal of organic chemistry 20050902

• 3,4-di-deoxyglucosone-3-ene promotes leukocyte apoptosis.

  Kidney international 20050901

• Protein glycation in Saccharomyces cerevisiae. Argpyrimidine formation and methylglyoxal catabolism.

  The FEBS journal 20050901

• Hydrogen-bonding patterns in six derivatives of 2,4-dimethylpyrrole.

  Acta crystallographica. Section C, Crystal structure communications 20050901

• Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.

  American journal of physiology. Renal physiology 20050801

• Effect of buformin and metformin on formation of advanced glycation end products by methylglyoxal.

  Clinica chimica acta; international journal of clinical chemistry 20050801

• Vascular methylglyoxal metabolism and the development of hypertension.

  Journal of hypertension 20050801

• Conversion of methylglyoxal to acetol by Escherichia coli aldo-keto reductases.

  Journal of bacteriology 20050801

• Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins.

  Chemical research in toxicology 20050801

• A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.

  PLoS genetics 20050801

• Suppressive effect of trehalose on acrylamide formation from asparagine and reducing saccharides.

  Bioscience, biotechnology, and biochemistry 20050801

• Micellar catalyzed degradation of fenitrothion, an organophosphorus pesticide, in solution and soils.

  Environmental science & technology 20050801

• Model studies on the influence of high hydrostatic pressure on the formation of glycated arginine modifications at elevated temperatures.

  Journal of agricultural and food chemistry 20050713

• Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds.

  Clinical science (London, England : 1979) 20050701

• Effect of methylglyoxal on intracellular calcium levels and viability in renal tubular cells.

  Cellular signalling 20050701

• Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050701

• Ilex paraguariensis extracts inhibit AGE formation more efficiently than green tea.

  Fitoterapia 20050701

• Evaluation of advanced glycation end products and carbonyl compounds in patients with different conditions of oxidative stress.

  Molecular nutrition & food research 20050701

• Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells.

  Diabetes 20050701

• Emergent mechanistic diversity of enzyme-catalysed beta-diketone cleavage.

  The Biochemical journal 20050615

• Tin-catalyzed conversion of trioses to alkyl lactates in alcohol solution.

  Chemical communications (Cambridge, England) 20050607

• D-lactate metabolism in starved Octopus ocellatus.

  Journal of experimental zoology. Part A, Comparative experimental biology 20050601

• Transport and metabolism of D-lactate in Jerusalem artichoke mitochondria.

  Biochimica et biophysica acta 20050601

• Chemistry and biological effects of melanoidins and glyceraldehyde-derived pyridinium as advanced glycation end products.

  Annals of the New York Academy of Sciences 20050601

• Dicarbonyl intermediates in the maillard reaction.

  Annals of the New York Academy of Sciences 20050601

• Formation of alpha-aminoadipic and gamma-glutamic semialdehydes in proteins by the maillard reaction.

  Annals of the New York Academy of Sciences 20050601

• Methylglyoxal can modify GAPDH activity and structure.

  Annals of the New York Academy of Sciences 20050601

• Effect of glucose concentration on formation of AGEs in erythrocytes in vitro.

  Annals of the New York Academy of Sciences 20050601

• Methylglyoxal induces apoptosis through oxidative stress-mediated activation of p38 mitogen-activated protein kinase in rat Schwann cells.

  Annals of the New York Academy of Sciences 20050601

• Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin.

  Annals of the New York Academy of Sciences 20050601

• Assessment of protein function following cross-linking by alpha-dicarbonyls.

  Annals of the New York Academy of Sciences 20050601

• Ketosis leads to increased methylglyoxal production on the Atkins diet.

  Annals of the New York Academy of Sciences 20050601

• Methylglyoxal, glyoxal, and their detoxification in Alzheimer's disease.

  Annals of the New York Academy of Sciences 20050601

• Evaluation of glyoxal and methylglyoxal levels in uremic patients under peritoneal dialysis.

  Annals of the New York Academy of Sciences 20050601

• Application of semiquantitative proteomics techniques to the maillard reaction.

  Annals of the New York Academy of Sciences 20050601

• Peptide mapping of human serum albumin modified minimally by methylglyoxal in vitro and in vivo.

  Annals of the New York Academy of Sciences 20050601

• A common pathway for intracellular reactive oxygen species production by glycoxidative and nitroxidative stress in vascular endothelial cells and smooth muscle cells.

  Annals of the New York Academy of Sciences 20050601

• Genotoxicity of advanced glycation end products: involvement of oxidative stress and of angiotensin II type 1 receptors.

  Annals of the New York Academy of Sciences 20050601

• Advanced glycation end products in human cancer tissues: detection of Nepsilon-(carboxymethyl)lysine and argpyrimidine.

  Annals of the New York Academy of Sciences 20050601

• Advanced glycation end product free adducts are cleared by dialysis.

  Annals of the New York Academy of Sciences 20050601

• High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats.

  Annals of the New York Academy of Sciences 20050601

• Proteins of Thermus thermophilus are resistant to glycation-induced protein precipitation: an evolutionary adaptation to life at extreme temperatures?

  Annals of the New York Academy of Sciences 20050601

• Analysis of Methylglyoxal Metabolism in CHO Cells Grown in Culture.

  Cytotechnology 20050601

• Analysis of methylglyoxal in water and biological matrices by capillary zone electrophoresis with diode array detection.

  Electrophoresis 20050501

• Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation.

  The FEBS journal 20050501

• CD36 is not involved in scavenger receptor-mediated endocytic uptake of glycolaldehyde- and methylglyoxal-modified proteins by liver endothelial cells.

  Journal of biochemistry 20050501

• Curcumin inhibits ROS formation and apoptosis in methylglyoxal-treated human hepatoma G2 cells.

  Annals of the New York Academy of Sciences 20050501

• In vivo prooxidant state in Werner syndrome (WS): results from three WS patients and two WS heterozygotes.

  Free radical research 20050501

• [Ozonolysis of methacrolein and methyl vinyl ketone in aqueous solutions].

  Huan jing ke xue= Huanjing kexue 20050501

• Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes.

  The Journal of biological chemistry 20050401

• Humoral methylglyoxal level reflects glycemic fluctuation.

  Clinical biochemistry 20050401

• Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification.

  Aging cell 20050401

• The HOG MAP kinase pathway is required for the induction of methylglyoxal-responsive genes and determines methylglyoxal resistance in Saccharomyces cerevisiae.

  Molecular microbiology 20050401

• The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode.

  PLoS biology 20050401

• The influence of various substances on the biomechanical behavior of lamina cribrosa and peripapillary sclera.

  Investigative ophthalmology & visual science 20050401

• Aminoacetone induces oxidative modification to human plasma ceruloplasmin.

  Chemical research in toxicology 20050401

• The annotated genome of Wolbachia from the filarial nematode Brugia malayi: what it means for progress in antifilarial medicine.

  PLoS medicine 20050401

• Albumin antioxidant capacity is modified by methylglyoxal.

  Diabetes & metabolism 20050401

• Characterization of advanced glycation end products for biochemical studies: side chain modifications and fluorescence characteristics.

  Analytical biochemistry 20050315

• Unique regulation of glyoxalase I activity during osmotic stress response in the fission yeast Schizosaccharomyces pombe: neither the mRNA nor the protein level of glyoxalase I increase under conditions that enhance its activity.

  Archives of microbiology 20050301

• Metabolic flux analysis of Escherichia coli in glucose-limited continuous culture. II. Dynamic response to famine and feast, activation of the methylglyoxal pathway and oscillatory behaviour.

  Microbiology (Reading, England) 20050301

• Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against inhibition of cardiac mitochondrial respiration by methylglyoxal.

  Molecular and cellular biochemistry 20050301

• Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity.

  The Journal of biological chemistry 20050218

• A H2O2-producing glyoxal oxidase is required for filamentous growth and pathogenicity in Ustilago maydis.

  Molecular genetics and genomics : MGG 20050201

• Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A).

  Diabetologia 20050201

• Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells.

  Diabetologia 20050201

• Diagnosis of cell death induced by methylglyoxal, a metabolite derived from glycolysis, in Saccharomyces cerevisiae.

  FEMS microbiology letters 20050201

• Maintenance of DeltapH by a butanol-tolerant mutant of Clostridium beijerinckii.

  Microbiology (Reading, England) 20050201

• Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy.

  PLoS medicine 20050201

• Argpyrimidine, a methylglyoxal-derived advanced glycation end-product in familial amyloidotic polyneuropathy.

  The Biochemical journal 20050115

• Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells.

  Free radical biology & medicine 20050115

• Methylglyoxal, a metabolite derived from glycolysis, functions as a signal initiator of the high osmolarity glycerol-mitogen-activated protein kinase cascade and calcineurin/Crz1-mediated pathway in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20050107

• The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production.

  Medical hypotheses 20050101

• The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal.

  Neurotoxicity research 20050101

• The pro-oxidant role of methylglyoxal in mesenteric artery smooth muscle cells.

  Canadian journal of physiology and pharmacology 20050101

• Measurement of methylglyoxal in rat tissues by electrospray ionization mass spectrometry and liquid chromatography.

  Journal of pharmacological and toxicological methods 20050101

• The microbial selenoproteome of the Sargasso Sea.

  Genome biology 20050101

• Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts.

  Biological chemistry 20050101

• Prospective randomized study comparing MEMID with a chop-like regimen in elderly patients with aggressive non-Hodgkin's lymphoma.

  Oncology 20050101

• Interaction preferences across protein-protein interfaces of obligatory and non-obligatory components are different.

  BMC structural biology 20050101

• Differential susceptibility of naive and differentiated PC-12 cells to methylglyoxal-induced apoptosis: influence of cellular redox.

  Current neurovascular research 20050101

• Natural history of S-adenosylmethionine-binding proteins.

  BMC structural biology 20050101

• A copper chelating agent suppresses carbonyl stress in diabetic rat lenses.

  Journal of diabetes and its complications 20050101

• [Mechanisms of hyperglycemia development and possible methods of carbohydrate metabolism normalization (review)].

  Terapevticheskii arkhiv 20050101

• Take care in how you store your PD fluids: actual temperature determines the balance between reactive and non-reactive GDPs.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20050101

• The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway.

  Human molecular genetics 20041215

• Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids.

  Journal of lipid research 20041201

• L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20041201

• Spectroscopic studies of methylglyoxal in water and dimethylsulfoxide.

  Bioorganic chemistry 20041201

• Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products.

  Clinical and experimental immunology 20041201

• Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats.

  Kidney international 20041201

• Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis.

  Journal of hepatology 20041201

• Conventional antibody against Nepsilon-(carboxymethyl)lysine (CML) shows cross-reaction to Nepsilon-(carboxyethyl)lysine (CEL): immunochemical quantification of CML with a specific antibody.

  Journal of biochemistry 20041201

• Determination of methylglyoxal in ruminal fluid by high-performance liquid chromatography using fluorometric detection.

  Journal of agricultural and food chemistry 20041117

• Effects of 1,3-butadiene, isoprene, and their photochemical degradation products on human lung cells.

  Environmental health perspectives 20041101

• Gender- and age-related distinctions for the in vivo prooxidant state in Fanconi anaemia patients.

  Carcinogenesis 20041001

• The cytotoxic mechanism of glyoxal involves oxidative stress.

  Biochemical pharmacology 20041001

• Preparation and quantification of methylglyoxal in human plasma using reverse-phase high-performance liquid chromatography.

  Clinical biochemistry 20041001

• Enhanced degradation and decreased stability of eye lens alpha-crystallin upon methylglyoxal modification.

  Experimental eye research 20041001

• Methotrexate inhibits the glyoxalase system in vivo in children with acute lymphoid leukaemia.

  European journal of cancer (Oxford, England : 1990) 20041001

• Degradation of tert-butyl alcohol in dilute aqueous solution by an O3/UV process.

  Environmental science & technology 20041001

• Toxic concentrations of exogenously supplied methylglyoxal in hybridoma cell culture.

  Cytotechnology 20041001

• Mechanism and kinetics of the reaction of OH radicals with glyoxal and methylglyoxal: a quantum chemistry + CVT/SCT approach.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20040920

• Mechanism of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase, a key enzyme in the methanopterin biosynthetic pathway.

  The Journal of biological chemistry 20040917

• Entropy effects on protein hinges: the reaction catalyzed by triosephosphate isomerase.

  Biochemistry 20040914

• Long-term exposure to new peritoneal dialysis solutions: Effects on the peritoneal membrane.

  Kidney international 20040901

• Genomic damage in end-stage renal failure: potential involvement of advanced glycation end products and carbonyl stress.

  Seminars in nephrology 20040901

• Identification of a maize kernel stress-related protein and its effect on aflatoxin accumulation.

  Phytopathology 20040901

• Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase.

  The Journal of biological chemistry 20040806

• Acceleration of nucleophilic attack on an organophosphorothioate neurotoxin, fenitrothion, by reactive counterion cationic micelles. Regioselectivity as a probe of substrate orientation within the micelle.

  Langmuir : the ACS journal of surfaces and colloids 20040803

• Functional characterisation of glyoxalase I from the fungal wheat pathogen Stagonospora nodorum.

  Current genetics 20040801

• N-Terminal pyrazinones: a new class of peptide-bound advanced glycation end-products.

  Amino acids 20040801

• Influence of irradiation and storage on the quality of ready-to-eat turkey breast rolls.

  Poultry science 20040801

• Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells.

  Biochemical and biophysical research communications 20040730

• Hydrothermal upgrading of biomass to biofuel; studies on some monosaccharide model compounds.

  Carbohydrate research 20040712

• Methylglyoxal: a stimulus to neutrophil oxygen radical production in chronic renal failure?

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040701

• Crystal structure of the schiff base intermediate prior to decarboxylation in the catalytic cycle of aspartate alpha-decarboxylase.

  Journal of molecular biology 20040625

• Interaction between methyl glyoxal and ascorbic acid: experimental and theoretical aspects.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040601

• Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes.

  Investigative ophthalmology & visual science 20040601

• Glyoxalase II of African trypanosomes is trypanothione-dependent.

  The Journal of biological chemistry 20040521

• Modulation of collagen proteolysis by chemical modification of amino acid side-chains in acellularized arteries.

  Biomaterials 20040501

• Identification of thermostable glyoxalase I in the fission yeast Schizosaccharomyces pombe.

  Archives of microbiology 20040501

• Methylglyoxal induces oxidative stress-dependent cell injury and up-regulation of interleukin-1beta and nerve growth factor in cultured hippocampal neuronal cells.

  Brain research 20040501

• Endogenous DNA damage in humans: a review of quantitative data.

  Mutagenesis 20040501

• Formation of genotoxic dicarbonyl compounds in dietary oils upon oxidation.

  Lipids 20040501

• Effect of dicarbonyl-induced browning on alpha-crystallin chaperone-like activity: physiological significance and caveats of in vitro aggregation assays.

  The Biochemical journal 20040415

• Mutagenic studies on histidine 98 of methylglyoxal synthase: effects on mechanism and conformational change.

  Biochemistry 20040406

• Involvement of SSAO-mediated deamination in adipose glucose transport and weight gain in obese diabetic KKAy mice.

  American journal of physiology. Endocrinology and metabolism 20040401

• Solid-phase microextraction for flavor analysis in Harari Khat (Catha edulis) stimulant.

  Journal of Zhejiang University. Science 20040401

• In vitro and in vivo models for peritonitis demonstrate unchanged neutrophil migration after exposure to dialysis fluids.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040401

• Tools for metabolic engineering in Escherichia coli: inactivation of panD by a point mutation.

  Analytical biochemistry 20040401

• S-adenosylmethionine decarboxylase degradation by the 26 S proteasome is accelerated by substrate-mediated transamination.

  The Journal of biological chemistry 20040326

• Phorbol 12-myristate 13-acetate protects Jurkat cells from methylglyoxal-induced apoptosis by preventing c-Jun N-terminal kinase-mediated leakage of cytochrome c in an extracellular signal-regulated kinase-dependent manner.

  Molecular pharmacology 20040301

• Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls.

  Chemical research in toxicology 20040301

• Yeast cells display a regulatory mechanism in response to methylglyoxal.

  FEMS yeast research 20040301

• Threonine is the best substrate for D-lactate formation in octopus tentacle.

  Amino acids 20040301

• Two distinct distributions of F-actin are present in the hyphal apex of the oomycete Achlya bisexualis.

  Plant & cell physiology 20040301

• Two separate pathways for d-lactate oxidation by Saccharomyces cerevisiae mitochondria which differ in energy production and carrier involvement.

  Biochimica et biophysica acta 20040215

• Methylglyoxal induces apoptosis mediated by reactive oxygen species in bovine retinal pericytes.

  Journal of Korean medical science 20040201

• Determination of airborne carbonyls: comparison of a thermal desorption/GC method with the standard DNPH/HPLC method.

  Environmental science & technology 20040201

• Determination of urinary glyoxal and methylglyoxal by high-performance liquid chromatography.

  Clinical chemistry and laboratory medicine 20040201

• Glucose toxicity effect and accumulation of methylglyoxal by the periodontal anaerobe Bacteroides forsythus.

  Anaerobe 20040201

• Investigation of metal binding and activation of Escherichia coli glyoxalase I: kinetic, thermodynamic and mutagenesis studies.

  The Biochemical journal 20040115

• Prevention of fructose-induced hypertension by dietary vitamins.

  Clinical biochemistry 20040101

• Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review.

  American journal of epidemiology 20040101

• Inhibition of tumor growth by replacing glutathione with N-acetyl-L-cysteine.

  Medical hypotheses 20040101

• Antioxidant defense in Plasmodium falciparum--data mining of the transcriptome.

  Malaria journal 20040101

• Evidence that high-dose L-arginine may be inappropriate for use by diabetic patients as a prophylactic blocker of methylglyoxal glycation.

  Journal of biomedical science 20040101

• Role of rpoS in the regulation of glyoxalase III in Escherichia coli.

  Acta biochimica Polonica 20040101

• BIOKID: randomized controlled trial comparing bicarbonate and lactate buffer in biocompatible peritoneal dialysis solutions in children [ISRCTN81137991].

  BMC nephrology 20040101

• Glutathione, altruistic metabolite in fungi.

  Advances in microbial physiology 20040101

• Synergistic cytotoxicity of acidity and glucose degradation products in peritoneal dialysis fluid.

  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 20040101

• Estimating genomic coexpression networks using first-order conditional independence.

  Genome biology 20040101

• Detection and determination of glyceraldehyde-derived advanced glycation end product.

  BioFactors (Oxford, England) 20040101

• Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins.

  Investigative ophthalmology & visual science 20031201

• The enzymatic defence against glycation in health, disease and therapeutics: a symposium to examine the concept.

  Biochemical Society transactions 20031201

• Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycation.

  Biochemical Society transactions 20031201

• Alpha-oxoaldehyde metabolism and diabetic complications.

  Biochemical Society transactions 20031201

• Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy.

  Biochemical Society transactions 20031201

• Glyoxalase I inhibitors in cancer chemotherapy.

  Biochemical Society transactions 20031201

• Anti-AGEing defences against Alzheimer's disease.

  Biochemical Society transactions 20031201

• Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus.

  Biochemical Society transactions 20031201

• Bacterial production of methylglyoxal: a survival strategy or death by misadventure?

  Biochemical Society transactions 20031201

• Anti-glycation defences in yeast.

  Biochemical Society transactions 20031201

• Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats.

  Biochemical Society transactions 20031201

• Advanced glycation endproduct precursor alters intracellular amyloid-beta/A beta PP carboxy-terminal fragment aggregation and cytotoxicity.

  Journal of Alzheimer's disease : JAD 20031201

• Oxidative damage of DNA induced by methylglyoxal in vitro.

  Toxicology letters 20031130

• Glucose degradation products (GDP) retard remesothelialization independently of D-glucose concentration.

  Kidney international 20031101

• Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts.

  Archives of biochemistry and biophysics 20031101

• Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice.

  Diabetes 20031101

• Oxidative damage of DNA by the reaction of amino acid with methylglyoxal in the presence of Fe(III).

  International journal of biological macromolecules 20031101

• Scavenging system efficiency is crucial for cell resistance to ROS-mediated methylglyoxal injury.

  Free radical biology & medicine 20031015

• Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency.

  Biochimica et biophysica acta 20031015

• Metabolism, not autoxidation, plays a role in alpha-oxoaldehyde- and reducing sugar-induced erythrocyte GSH depletion: relevance for diabetes mellitus.

  Molecular and cellular biochemistry 20031001

• Aminoacetone induces loss of ferritin ferroxidase and iron uptake activities.

  Free radical research 20031001

• Enhancement of chaperone function of alpha-crystallin by methylglyoxal modification.

  Biochemistry 20030916

• Rapid suppression of mitochondrial permeability transition by methylglyoxal. Role of reversible arginine modification.

  The Journal of biological chemistry 20030912

• Methylglyoxal modifies heat shock protein 27 in glomerular mesangial cells.

  FEBS letters 20030911

• Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes. Formation of modified and oxidized particles.

  European journal of biochemistry 20030901

• Volatile organic compounds in rural atmospheres of central Portugal.

  The Science of the total environment 20030901

• Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20030901

• Metformin inhibition of glycation processes.

  Diabetes & metabolism 20030901

• Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC/MS method.

  Clinical chemistry and laboratory medicine 20030901

• OH radical-initiated reaction of 3-hexene-2,5-dione: formation of methylglyoxal.

  Environmental science & technology 20030801

• Kinetic modelling of Amadori N-(1-deoxy-D-fructos-1-yl)-glycine degradation pathways. Part I--reaction mechanism.

  Carbohydrate research 20030729

• Kinetic modelling of Amadori N-(1-deoxy-D-fructos-1-yl)-glycine degradation pathways. Part II--kinetic analysis.

  Carbohydrate research 20030729

• Mitochondrial phosphatidylserine decarboxylase from higher plants. Functional complementation in yeast, localization in plants, and overexpression in Arabidopsis.

  Plant physiology 20030701

• Protective effect of creatine against inhibition by methylglyoxal of mitochondrial respiration of cardiac cells.

  The Biochemical journal 20030601

• Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice.

  Diabetes 20030601

• The molecular chaperone alpha-crystallin incorporated into red cell ghosts protects membrane Na/K-ATPase against glycation and oxidative stress.

  European journal of biochemistry 20030601

• Identification of N epsilon-(carboxyethyl)lysine, one of the methylglyoxal-derived AGE structures, in glucose-modified protein: mechanism for protein modification by reactive aldehydes.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030505

• Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae.

  Yeast (Chichester, England) 20030430

• Modification and inactivation of human Cu,Zn-superoxide dismutase by methylglyoxal.

  Molecules and cells 20030430

• The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules?

  Life sciences 20030425

• Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal.

  Journal of cellular biochemistry 20030415

• Physiological and pathological implications of semicarbazide-sensitive amine oxidase.

  Biochimica et biophysica acta 20030411

• Oxidative deamination of benzylamine by glycoxidation.

  Bioorganic & medicinal chemistry 20030403

• Glucose degradation products increase apoptosis of human mesothelial cells.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20030401

• Accumulation of methylglyoxal in the gingival crevicular fluid of chronic periodontitis patients.

  Journal of clinical periodontology 20030401

• Glutathione--functions and metabolism in the malarial parasite Plasmodium falciparum.

  Biological chemistry 20030401

• New insights into protein crosslinking via the Maillard reaction: structural requirements, the effect on enzyme function, and predicted efficacy of crosslinking inhibitors as anti-ageing therapeutics.

  Bioorganic & medicinal chemistry 20030320

• The role of dicarbonyl compounds in non-enzymatic crosslinking: a structure-activity study.

  Bioorganic & medicinal chemistry 20030320

• Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant.

  Biochemistry 20030304

• Formation of advanced glycation end products during CAPD.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20030301

• Pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii: crystal structures of the self-cleaved and S53A proenzyme forms.

  Structure (London, England : 1993) 20030301

• Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells.

  Kidney international 20030301

• A practical method to study functional impairment of proteins by glycation and effects of inhibitors using current coagulation/fibrinolysis reagent kits.

  Clinical biochemistry 20030301

• Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii.

  The Biochemical journal 20030201

• Methylglyoxal-induced glycation affects protein topography.

  Archives of biochemistry and biophysics 20030201

• Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes.

  Metabolism: clinical and experimental 20030201

• Up-regulation of aldose reductase by the substrate, methylglyoxal.

  Chemico-biological interactions 20030201

• Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase.

  Chemico-biological interactions 20030201

• Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells.

  Kidney international 20030201

• Identification of the binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185.

  Free radical research 20030201

• DNA damage by carbonyl stress in human skin cells.

  Mutation research 20030128

• A novel aldo-keto reductase from Escherichia coli can increase resistance to methylglyoxal toxicity.

  FEMS microbiology letters 20030121

• Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes.

  Biochimica et biophysica acta 20030120

• Dihydroxyacetone kinases in Saccharomyces cerevisiae are involved in detoxification of dihydroxyacetone.

  The Journal of biological chemistry 20030117

• Methylglyoxal-bovine serum albumin stimulates tumor necrosis factor alpha secretion in RAW 264.7 cells through activation of mitogen-activating protein kinase, nuclear factor kappaB and intracellular reactive oxygen species formation.

  Archives of biochemistry and biophysics 20030115

• Short term feeding of hexadienal to postnatal rats: effects on stomach aldehyde dehydrogenase.

  Toxicology letters 20030113

• Different activity of glyoxalase system enzymes in specimens of Sparus auratus exposed to sublethal copper concentrations.

  Chemico-biological interactions 20030106

• Glucose degradation products in PD fluids: do they disappear from the peritoneal cavity and enter the systemic circulation?

  Kidney international 20030101

• Affinity adsorption of glucose degradation products improves the biocompatibility of conventional peritoneal dialysis fluid.

  Kidney international 20030101

• Improved superoxide-generating system suitable for the assessment of the superoxide-scavenging ability of aqueous extracts of food constituents using ultraweak chemiluminescence.

  Journal of agricultural and food chemistry 20030101

• Excited state complex formation between methyl glyoxal and some aromatic bio-molecules: a fluorescence quenching study.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030101

• An effective derivatization method for quantitative determination of glyoxal and methylglyoxal in plasma samples by gas chromatography/mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20030101

• Single exposure of mesothelial cells to glucose degradation products (GDPs) yields early advanced glycation end-products (AGEs) and a proinflammatory response.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20030101

• Hyper-vascular change and formation of advanced glycation endproducts in the peritoneum caused by methylglyoxal and the effect of an anti-oxidant, sodium sulfite.

  American journal of nephrology 20030101

• [Implication of methylglyoxal in diabetes mellitus].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20030101

• Synthesis and biological activities of turkesterone 11alpha-acyl derivatives.

  Journal of insect science (Online) 20030101

• Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation.

  Biochemistry 20021210

• The botanical extracts of Achyrocline satureoides and Ilex paraguariensis prevent methylglyoxal-induced inhibition of plasminogen and antithrombin III.

  Life sciences 20021206

• Molecular mechanisms of the cross-impact of pathological processes in combined diabetes and cancer. Research and clinical aspects.

  Biochemistry. Biokhimiia 20021201

• Glycated proteins can enhance photooxidative stress in aged and diabetic lenses.

  Free radical research 20021201

• Modulation of heat-shock protein 27 (Hsp27) anti-apoptotic activity by methylglyoxal modification.

  The Journal of biological chemistry 20021129

• Methylglyoxal synthetase, enol-pyruvaldehyde, glutathione and the glyoxalase system.

  Journal of the American Chemical Society 20021106

• Oxidative deamination of lysine residue in plasma protein of diabetic rats. Novel mechanism via the Maillard reaction.

  European journal of biochemistry 20021101

• Possible mechanism for involvement of cysteine in aroma production in wine.

  Journal of agricultural and food chemistry 20021009

• Semicarbazide-sensitive amine oxidase in aortic smooth muscle cells mediates synthesis of a methylglyoxal-AGE: implications for vascular complications in diabetes.

  Biochemical and biophysical research communications 20021004

• Study of a glucose-activated anion-selective channel in rat pancreatic beta-cells.

  Pflugers Archiv : European journal of physiology 20021001

• Concentrations of formaldehyde and other carbonyls in environments affected by incense burning.

  Journal of environmental monitoring : JEM 20021001

• A novel beta-diketone-cleaving enzyme from Acinetobacter johnsonii: acetylacetone 2,3-oxygenase.

  Biochemical and biophysical research communications 20020920

• Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas.

  European journal of cancer (Oxford, England : 1990) 20020901

• Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet.

  Diabetologia 20020901

• Immunolocalization and quantification of advanced glycation end products in retinal neovascular membranes and serum: a possible role in ocular neovascularization.

  Current eye research 20020901

• Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid.

  Kidney international 20020801

• D-Lactate transport and metabolism in rat liver mitochondria.

  The Biochemical journal 20020715

• Inactivation of cellular enzymes by carbonyls and protein-bound glycation/glycoxidation products.

  Archives of biochemistry and biophysics 20020715

• Identification and quantification of major maillard cross-links in human serum albumin and lens protein. Evidence for glucosepane as the dominant compound.

  The Journal of biological chemistry 20020712

• Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal.

  American journal of physiology. Renal physiology 20020701

• Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse.

  Diabetes 20020701

• Methanococcus jannaschii uses a pyruvoyl-dependent arginine decarboxylase in polyamine biosynthesis.

  The Journal of biological chemistry 20020628

• Effects of modifications of alpha-crystallin on its chaperone and other properties.

  The Biochemical journal 20020615

• Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal.

  Archives of biochemistry and biophysics 20020601

• Conversion of Amadori products of the Maillard reaction to N(epsilon)-(carboxymethyl)lysine by short-term heating: possible detection of artifacts by immunohistochemistry.

  Laboratory investigation; a journal of technical methods and pathology 20020601

• New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: formation of imino acid-nucleic base derivatives in water under mild conditions.

  Chemical communications (Cambridge, England) 20020521

• Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes.

  Chemico-biological interactions 20020520

• Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and intrinsic fluorescence.

  The Biochemical journal 20020515

• Ambient air measurement of acrolein and other carbonyls at the Oakland-San Francisco Bay Bridge toll plaza.

  Environmental science & technology 20020515

• Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes.

  Molecular pharmacology 20020501

• Advanced glycation end product precursors impair epidermal growth factor receptor signaling.

  Diabetes 20020501

• A possible regulatory role of glyoxalase I in cell viability of human prostate cancer.

  Urological research 20020501

• Tuning of the optical and electrochemical properties of the primary donor bacteriochlorophylls in the reaction centre from Rhodobacter sphaeroides: spectroscopy and structure.

  Biochimica et biophysica acta 20020422

• Optimization of a mist chamber (Cofer scrubber) for sampling water-soluble organics in air.

  Environmental science & technology 20020415

• Catalysis and stability of triosephosphate isomerase from Trypanosoma brucei with different residues at position 14 of the dimer interface. Characterization of a catalytically competent monomeric enzyme.

  Biochemistry 20020402

• Cellular oxidant stress and advanced glycation endproducts of albumin: caveats of the dichlorofluorescein assay.

  Archives of biochemistry and biophysics 20020401

• Speciated ambient carbonyls in Rio de Janeiro, Brazil.

  Environmental science & technology 20020401

• Qualitative determination of specific protein glycation products by matrix-assisted laser desorption/ionization mass spectrometry Peptide mapping.

  Journal of agricultural and food chemistry 20020327

• Assessment of antibody responses to antigens of Mycobacterium tuberculosis and Cysticercus cellulosae in cerebrospinal fluid of chronic meningitis patients for definitive diagnosis as TBM/NCC by passive hemagglutination and immunoblot assays.

  FEMS immunology and medical microbiology 20020325

• Feasibility of collection and analysis of airborne carbonyls by on-sorbent derivatization and thermal desorption.

  Analytical chemistry 20020315

• Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells.

  Hypertension (Dallas, Tex. : 1979) 20020301

• Effects of thermal denaturation on protein glycation.

  Life sciences 20020301

• Generation of superoxide anions during the reaction of guanidino compounds with methylglyoxal.

  Chemical & pharmaceutical bulletin 20020201

• Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress.

  Biochemical pharmacology 20020201

• Methylglyoxal enhances cisplatin-induced cytotoxicity by activating protein kinase Cdelta.

  The Journal of biological chemistry 20020125

• Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease.

  Free radical biology & medicine 20020101

• Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis.

  Arthritis and rheumatism 20020101

• Glucocorticoids and polyamine inhibitors synergize to kill human leukemic CEM cells.

  Neoplasia (New York, N.Y.) 20020101

• Passive cigarette smoke and the renal glyoxalase system.

  Molecular and cellular biochemistry 20020101

• Comparison between modifications of lens proteins resulted from glycation with methylglyoxal, glyoxal, ascorbic acid, and fructose.

  Journal of biochemical and molecular toxicology 20020101

• Improving 1,3-propanediol production from glycerol in a metabolically engineered Escherichia coli by reducing accumulation of sn-glycerol-3-phosphate.

  Biotechnology progress 20020101

• Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options.

  International review of neurobiology 20020101

• Regulation of the glyoxalase pathway in human brain microvascular endothelium: effects of troglitazone and tertiary butylhydroperoxide.

  Endothelium : journal of endothelial cell research 20020101

• Potential trace metal-organic complexation in the atmosphere.

  TheScientificWorldJournal 20020101

• Role of iron in the interaction of red blood cells with methylglyoxal. Modification of L-arginine by methylglyoxal is catalyzed by iron redox cycling.

  Chemico-biological interactions 20011128

• Glyoxal and methylglyoxal induce lyoxal and methyglyoxal induce aggregation and inactivation of ERK in human endothelial cells.

  Free radical biology & medicine 20011115

• Morphofunctional mitochondrial response to methylglyoxal toxicity in Bufo bufo embryos.

  The international journal of biochemistry & cell biology 20011101

• Prolonged exposure to glucose degradation products impairs viability and function of human peritoneal mesothelial cells.

  Journal of the American Society of Nephrology : JASN 20011101

• Troglitazone selectively inhibits glyoxalase I gene expression.

  Diabetologia 20011101

• Continuous angiotensin II infusion increases tumour: normal blood flow ratio in colo-rectal liver metastases.

  British journal of cancer 20011101

• Immunological detection of a novel advanced glycation end-product.

  Molecular medicine (Cambridge, Mass.) 20011101

• Catalytic mechanism of glyoxalase I: a theoretical study.

  Journal of the American Chemical Society 20011024

• Highly efficient Aerococcus viridans L-alpha-glycerophosphate oxidase production in the presence of H2O2-decomposing agent: purification and kinetic characterization.

  Applied microbiology and biotechnology 20011001

• Plants synthesize ethanolamine by direct decarboxylation of serine using a pyridoxal phosphate enzyme.

  The Journal of biological chemistry 20010921

• Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups.

  Mechanisms of ageing and development 20010915

• Aerobic oxidation of aminoacetone, a threonine catabolite: iron catalysis and coupled iron release from ferritin.

  Chemical research in toxicology 20010901

• Aldehyde and monocyclic aromatic hydrocarbon mixing ratios at an urban site in Las Vegas, Nevada.

  Journal of the Air & Waste Management Association (1995) 20010901

• Polyamine regulation of the rat pro-opiomelanocortin gene expression in AtT-20 cells.

  Journal of neuroendocrinology 20010901

• Inhibitory effects of S-nitrosoglutathione on cell proliferation and DNA synthesis: possible role of glyoxalase I inactivation.

  Chemico-biological interactions 20010831

• Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process.

  Free radical biology & medicine 20010815

• Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant.

  Biochemistry 20010814

• Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010801

• High concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells.

  Current eye research 20010801

• Active site structure and mechanism of human glyoxalase I-an ab initio theoretical study.

  Journal of the American Chemical Society 20010725

• Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells.

  Free radical biology & medicine 20010701

• Accumulation of methylglyoxal in anaerobically grown Escherichia coli and its detoxification by expression of the Pseudomonas putida glyoxalase I gene.

  Metabolic engineering 20010701

• The Saccharomyces cerevisiae aldose reductase is implied in the metabolism of methylglyoxal in response to stress conditions.

  Current genetics 20010701

• In situ analysis of methylglyoxal metabolism in Saccharomyces cerevisiae.

  FEBS letters 20010615

• Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy.

  Biochemistry 20010612

• Cytotoxic action of methylglyoxal on insulin-secreting cells.

  Biochemical pharmacology 20010601

• Evaluation of media and derivatization chemistry for six aldehydes in a passive sampler.

  Environmental science & technology 20010601

• In vitro processing of the proproteins GrdE of protein B of glycine reductase and PrdA of D-proline reductase from Clostridium sticklandii: formation of a pyruvoyl group from a cysteine residue.

  European journal of biochemistry 20010601

• The sugar model: catalytic flow reactor dynamics of pyruvaldehyde synthesis from triose catalyzed by poly-l-lysine contained in a dialyzer.

  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20010601

• Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses.

  Investigative ophthalmology & visual science 20010501

• Genetic and biochemical characterization of a short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus.

  European journal of biochemistry 20010501

• A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I.

  The Journal of biological chemistry 20010406

• The importance of hinge sequence for loop function and catalytic activity in the reaction catalyzed by triosephosphate isomerase.

  Journal of molecular biology 20010406

• Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro.

  Journal of biochemistry 20010401

• alpha-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia.

  Diabetes care 20010401

• Ozone removal in the sampling of parts per billion levels of terpenoid compounds: an evaluation of different scrubber materials.

  Environmental science & technology 20010401

• Sugar-mediated crosslinking of alpha-biotinylated-Lys to cysteamine-agarose support: a method to isolate Maillard Lys-Lys-like crosslinks.

  Applied biochemistry and biotechnology 20010401

• Effect of methylglyoxal on mouse embryogenesis.

  Chang Gung medical journal 20010401

• Protein glycation: creation of catalytic sites for free radical generation.

  Annals of the New York Academy of Sciences 20010401

• 2-Bromoethylamine as a potent selective suicide inhibitor for semicarbazide-sensitive amine oxidase.

  Biochemical pharmacology 20010315

• Chromatographic quantification of argpyrimidine, a methylglyoxal-derived product in tissue proteins: comparison with pentosidine.

  Analytical biochemistry 20010301

• Brief history of glyoxalase I and what we have learned about metal ion-dependent, enzyme-catalyzed isomerizations.

  Archives of biochemistry and biophysics 20010301

• Expression of glyoxalase I and II in normal and breast cancer tissues.

  Breast cancer research and treatment 20010301

• Catalase has a novel protective role against electrophile killing of Xanthomonas.

  Microbiology (Reading, England) 20010201

• A stress-responsive glyoxalase I from the parasitic nematode Onchocerca volvulus.

  The Biochemical journal 20010201

• Low-density lipoprotein (LDL)-induced monocyte-endothelial cell adhesion, soluble cell adhesion molecules, and autoantibodies to oxidized-LDL in chronic renal failure patients on dialysis therapy.

  Metabolism: clinical and experimental 20010201

• Carbohydrate and amino acid degradation pathways in L-methionine/D-[13C] glucose model systems.

  Journal of agricultural and food chemistry 20010201

• Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications.

  Chemico-biological interactions 20010130

• The crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding.

  Chemico-biological interactions 20010130

• Chemistry and pathobiology of advanced glycation end products.

  Contributions to nephrology 20010101

• N(delta)-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine, a novel methylglyoxal-arginine modification in beer.

  Journal of agricultural and food chemistry 20010101

• Microbial formation, biotechnological production and applications of 1,2-propanediol.

  Applied microbiology and biotechnology 20010101

• The sugar model: catalysis by amines and amino acid products.

  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20010101

• Oxidation of albumin is enhanced in the presence of uremic toxins.

  Renal failure 20010101

• Sodium sulfite and N-acetylcysteine: new additives to dialysate for inhibiting formation of glucose degradation products and advanced glycation end-products.

  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20010101

• Non-enzymatic glycosylation of a type I collagen matrix: effects on osteoblastic development and oxidative stress.

  BMC cell biology 20010101

• [Molecular mechanisms of metabolic adaptation in pathological changed liver during toxic hepatitis ].

  Voprosy meditsinskoi khimii 20010101

• AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?

  Biogerontology 20010101

• Early glycated albumin, but not advanced glycated albumin, methylglyoxal, or 3-deoxyglucosone increases the expression of PAI-1 in human peritoneal mesothelial cells.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20010101

• Glucose degradation products in peritoneal dialysis fluids may have both local and systemic effects: a study of residual fluid and mesothelial cells.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20010101

• Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.

  The Biochemical journal 19991015

• Immunological evidence for methylglyoxal-derived modifications in vivo. Determination of antigenic epitopes.

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• Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes.

  Biochemical pharmacology 19970425

• Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 19950101

• The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal.

  European journal of biochemistry 19930215