784-71-4 | 2'-Deoxy-2'-fluorouridine

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$9.00	$6.00
1g	98%	in stock	$13.00	$9.00
5g	98%	in stock	$33.00	$23.00
25g	98%	in stock	$127.00	$89.00
100g	98%	in stock	$504.00	$353.00

Description

• Catalog Number: AB47393
• Chemical Name: 2'-Deoxy-2'-fluorouridine
• CAS Number: 784-71-4
• Molecular Formula: C9H11FN2O5
• Molecular Weight: 246.1924
• MDL Number: MFCD01317293
• SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)F)n1ccc(=O)[nH]c1=O

Computed Properties

• Complexity: 374
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -1

Literature

• Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides.

  Bioorganic & medicinal chemistry 20051215

• Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

  Journal of medicinal chemistry 20050825

• Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.

  Bioorganic & medicinal chemistry 20050301

• Recognition of an unnatural difluorophenyl nucleotide by uracil DNA glycosylase.

  Biochemistry 20041214

• Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041001

• Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-beta-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships.

  Journal of medicinal chemistry 19830201