80418-24-2 | Notoginsenoside R1

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$93.00	$65.00
10mg	≥98%	in stock	$174.00	$122.00
20mg	analytical standard ,≥98% (HPLC)	in stock	$225.00	$158.00

Description

• Catalog Number: AI56611
• Chemical Name: Notoginsenoside R1
• CAS Number: 80418-24-2
• Molecular Formula: C47H80O18
• Molecular Weight: 933.1273
• MDL Number: MFCD00210535
• SMILES: OC[C@H]1O[C@@H](O[C@H]2C[C@]3(C)[C@@H]([C@@]4([C@@H]2C(C)(C)[C@@H](O)CC4)C)C[C@H]([C@H]2[C@@]3(C)CC[C@@H]2[C@@](O[C@@H]2O[C@H](CO)[C@H]([C@@H]([C@H]2O)O)O)(CCC=C(C)C)C)O)[C@@H]([C@H]([C@@H]1O)O)O[C@@H]1OC[C@H]([C@@H]([C@H]1O)O)O

Computed Properties

• Complexity: 1670
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 25
• Heavy Atom Count: 65
• Hydrogen Bond Acceptor Count: 18
• Hydrogen Bond Donor Count: 12
• Rotatable Bond Count: 12
• XLogP3: 1.1

Literature

• Role of Chinese herbal medicinal ingredients in secretion of cytokines by PCV2-induced endothelial cells.

  Journal of immunotoxicology 20160101

• Effects of notoginsenoside R1 on CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 activities in rats by cocktail probe drugs.

  Pharmaceutical biology 20160101

• Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling.

  Biochemical and biophysical research communications 20151016

• Estrogen receptor α mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes.

  Molecular medicine reports 20150701

• Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3.

  British journal of pharmacology 20150201

• Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation.

  The Journal of pharmacology and experimental therapeutics 20150201

• Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation.

  CNS & neurological disorders drug targets 20150101

• Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457.

  International journal of clinical and experimental pathology 20150101

• ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury.

  American journal of physiology. Heart and circulatory physiology 20141215

• Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation.

  International immunopharmacology 20140901

• Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways.

  Free radical research 20140701

• Dissecting active ingredients of Chinese medicine by content-weighted ingredient-target network.

  Molecular bioSystems 20140701

• Notoginsenoside R1-mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: a novel mechanism of Nrf2/ARE signaling activation.

  Free radical research 20140401

• Protective effects of Notoginsenoside R1 on intestinal ischemia-reperfusion injury in rats.

  American journal of physiology. Gastrointestinal and liver physiology 20140101

• Notoginsenoside R1 attenuates atherosclerotic lesions in ApoE deficient mouse model.

  PloS one 20140101

• Notoginsenoside R1 attenuates hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of ERK.

  The American journal of Chinese medicine 20140101

• Protective effects of panax notoginseng saponins on cardiovascular diseases: a comprehensive overview of experimental studies.

  Evidence-based complementary and alternative medicine : eCAM 20140101

• Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation.

  Scientific reports 20140101

• Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice.

  Pharmacognosy magazine 20140101

• Notoginsenoside R1 ameliorates podocyte adhesion under diabetic condition through α3β1 integrin upregulation in vitro and in vivo.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20140101

• Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling.

  British journal of pharmacology 20130401

• The effects of notoginsenoside R₁ on the intestinal absorption of geniposide by the everted rat gut sac model.

  Journal of ethnopharmacology 20120626

• Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen.

  Journal of medicinal food 20120401

• New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1).

  Chemical & pharmaceutical bulletin 20120101

• [In vivo distribution and pharmacokinetics of multiple effective components contained in Panax notoginseng saponins after intratympanic administration].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110701

• [Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].

  Yao xue xue bao = Acta pharmaceutica Sinica 20101101

• Notoginsenoside R1 attenuates renal ischemia-reperfusion injury in rats.

  Shock (Augusta, Ga.) 20100901

• [Study on preparation and quality standard of Xueshuantong Drop Pills].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100801

• Characterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix notoginseng.

  Journal of agricultural and food chemistry 20100512

• [In vitro balanced sustained-release of Panax notoginseng saponins controlled with various matrix materials].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100401

• Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly.

  Journal of neuroscience research 20090701

• Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion.

  World journal of gastroenterology 20080107

• Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells.

  International journal of oncology 20071101

• [Studies on chemical constituents from rhizomes of Panax notoginseng].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071101

• Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery.

  Life sciences 20070719

• Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.

  Journal of natural products 20070701

• [RP-HPLC characteristics of Panax notoginseng].

  Yao xue xue bao = Acta pharmaceutica Sinica 20061101

• [Determination of notoginsenoside R1 and ginsenoside Rg1 in Rupixiao tablets by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060701

• Ginsenoside Re and notoginsenoside R1: Immunologic adjuvants with low haemolytic effect.

  Chemistry & biodiversity 20060701

• Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway.

  Free radical biology & medicine 20060501

• Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction.

  Journal of pharmaceutical and biomedical analysis 20060411

• Notoginsenoside R1 from Panax notoginseng inhibits TNF-alpha-induced PAI-1 production in human aortic smooth muscle cells.

  Vascular pharmacology 20060401

• Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI).

  Chemical & pharmaceutical bulletin 20060401

• [Cell proliferation inhibitive and apoptosis promoting effects of sanchi extract on GES-1 cell after being transformed by MNNG].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050801

• Orthogonal array design in optimizing the extraction efficiency of active constituents from roots of Panax notoginseng.

  Phytotherapy research : PTR 20050801

• [Determination of notoginsenoside R1, ginsenoside Rg1 and Rb1 in Radix Notoginseng and its preparation by HPLC-ELSD].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050101

• Absorption profiles of sanchinoside R1 and ginsenoside Rg1 in the rat intestine.

  European journal of drug metabolism and pharmacokinetics 20050101

• HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies.

  Biomedical chromatography : BMC 20041201

• [Up-regulation of transcription factors NF-E2, c-jun and c-fos of AP-1 family induced by Panax Notoginosides in hematopoietic cells].

  Zhongguo shi yan xue ye xue za zhi 20040201

• [Identification of Panax notoginseng and its preparations by LC/MS].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040201

• [Effects of root rot on saponin content in Panax notoginseng].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040201

• [Effect of Panax notoginsenosides on the proliferation of hematopoietic progenitor cells in mice with immune-mediated aplastic anemia].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20030901

• Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.

  Journal of natural products 20030701

• Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells.

  Journal of natural products 20020901

• Bioactive saponins and glycosides. XIX. Notoginseng (3): immunological adjuvant activity of notoginsenosides and related saponins: structures of notoginsenosides-L, -M, and -N from the roots of Panax notoginseng (Burk.) F. H. Chen.

  Chemical & pharmaceutical bulletin 20011101

• Effect of notoginsenoside R1 on the synthesis of components of the fibrinolytic system in cultured smooth muscle cells of human pulmonary artery.

  Cellular and molecular biology (Noisy-le-Grand, France) 19970601

• Notoginsenoside R1 counteracts endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo.

  Arteriosclerosis, thrombosis, and vascular biology 19970301

• Effect of notoginsenoside R1 on the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells.

  Arteriosclerosis and thrombosis : a journal of vascular biology 19940701