844499-71-4 | A-769662

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$8.00	$6.00
5mg	98%	in stock	$22.00	$16.00
10mg	98%	in stock	$33.00	$23.00
50mg	98%	in stock	$90.00	$63.00

Description

• Catalog Number: AB50666
• Chemical Name: A-769662
• CAS Number: 844499-71-4
• Molecular Formula: C20H12N2O3S
• Molecular Weight: 360.3859
• MDL Number: MFCD11977269
• SMILES: N#Cc1c(=O)[nH]c2c(c1O)c(cs2)c1ccc(cc1)c1ccccc1O

Computed Properties

• Complexity: 647
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: 4.1

Literature

• Effect of A-769662, a direct AMPK activator, on Tlr-4 expression and activity in mice heart tissue.

  Iranian journal of basic medical sciences 20161201

• Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro.

  Neuropharmacology 20160901

• Bavachalcone-induced manganese superoxide dismutase expression through the AMP-activated protein kinase pathway in human endothelial cells.

  Pharmacology 20150101

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Activation of AMP-activated protein kinase inhibits the proliferation of human endothelial cells.

  The Journal of pharmacology and experimental therapeutics 20120901

• Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells.

  The Journal of biological chemistry 20120706

• The ancient drug salicylate directly activates AMP-activated protein kinase.

  Science (New York, N.Y.) 20120518

• AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.

  The Biochemical journal 20120401

• Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells.

  Cell cycle (Georgetown, Tex.) 20120301

• Monitoring metabolites consumption and secretion in cultured cells using ultra-performance liquid chromatography quadrupole-time of flight mass spectrometry (UPLC-Q-ToF-MS).

  Analytical and bioanalytical chemistry 20120101

• 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent.

  The Journal of pharmacology and experimental therapeutics 20111201

• A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.

  Journal of molecular and cellular cardiology 20110701

• Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway.

  The Journal of pharmacology and experimental therapeutics 20110401

• AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells.

  Diabetologia 20110101

• Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.

  Protein expression and purification 20101001

• Stimulation of human and mouse erythrocyte Na(+)-K(+)-2Cl(-) cotransport by osmotic shrinkage does not involve AMP-activated protein kinase, but is associated with STE20/SPS1-related proline/alanine-rich kinase activation.

  The Journal of physiology 20100701

• AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells.

  Biochemical and biophysical research communications 20100604

• Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase.

  Molecular membrane biology 20100401

• Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species.

  Free radical research 20100201

• Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes.

  The Journal of biological chemistry 20100115

• AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase.

  American journal of physiology. Cell physiology 20091201

• A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

  American journal of physiology. Cell physiology 20091001

• Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis.

  Biological & pharmaceutical bulletin 20090601

• AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells.

  American journal of physiology. Cell physiology 20090401

• Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle.

  Endocrinology 20090201

• Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.

  IUBMB life 20090101

• Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

  Chemistry & biology 20081124

• Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

  The Journal of biological chemistry 20071109

• Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

  The Journal of biological chemistry 20071109

• Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

  Cell metabolism 20060601