84687-43-4 | Astragaloside iv

Packsize	Purity	Availability	Price	Discounted Price
100mg	≥ 98% (HPLC)	in stock	$55.00	$38.00
250mg	≥ 98% (HPLC)	in stock	$83.00	$58.00
1g	≥ 98% (HPLC)	in stock	$148.00	$103.00
5g	≥ 98% (HPLC)	in stock	$612.00	$428.00

Description

• Catalog Number: AC32806
• Chemical Name: Astragaloside iv
• CAS Number: 84687-43-4
• Molecular Formula: C41H68O14
• Molecular Weight: 784.9702
• MDL Number: MFCD16036240
• SMILES: OC[C@H]1O[C@@H](O[C@@H]2CC3C4([C@@]5(C2C(C)(C)C(CC5)O[C@@H]2OC[C@H]([C@@H]([C@H]2O)O)O)C4)CC[C@]2([C@@]3(C)C[C@H]([C@@H]2[C@@]2(C)CC[C@H](O2)C(O)(C)C)O)C)[C@@H]([C@H]([C@@H]1O)O)O

Computed Properties

• Complexity: 1460
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 21
• Heavy Atom Count: 55
• Hydrogen Bond Acceptor Count: 14
• Hydrogen Bond Donor Count: 9
• Rotatable Bond Count: 7
• XLogP3: 1.3

Literature

• Astragaloside IV ameliorates acute pancreatitis in rats by inhibiting the activation of nuclear factor-κB.

  International journal of molecular medicine 20150301

• Astragaloside IV attenuates Toll-like receptor 4 expression via NF-κB pathway under high glucose condition in mesenchymal stem cells.

  European journal of pharmacology 20121205

• Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120815

• Effects of astragaloside IV on eosinophil activation induced by house dust mite allergen.

  Molecular medicine reports 20120701

• Astragaloside IV attenuates complement membranous attack complex induced podocyte injury through the MAPK pathway.

  Phytotherapy research : PTR 20120601

• Astragaloside IV inhibits apoptotic cell death in the guinea pig cochlea exposed to impulse noise.

  Acta oto-laryngologica 20120501

• Astragaloside IV prevents MPP⁺-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production.

  Molecular and cellular biochemistry 20120501

• Determination of astragalin and astragaloside content in Radix Astragali using high-performance liquid chromatography coupled with pulsed amperometric detection.

  Journal of chromatography. A 20120406

• Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.

  Journal of ethnopharmacology 20120306

• Topical astragaloside IV-releasing hydrogel improves healing of skin wounds in vivo.

  Biological & pharmaceutical bulletin 20120101

• [Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

• Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo.

  PloS one 20120101

• Astragaloside IV alleviates hypoxia/reoxygenation-induced neonatal rat cardiomyocyte injury via the protein kinase a pathway.

  Pharmacology 20120101

• Therapeutic effects of astragaloside IV on myocardial injuries: multi-target identification and network analysis.

  PloS one 20120101

• Ultrasonic-assisted liquid-liquid extraction and HILIC-ELSD analysis of ginsenoside Rb(1), astragaloside IV and dulcitol in sugar-free 'Fufangfufangteng Heji'.

  Journal of pharmaceutical and biomedical analysis 20111205

• [Immunoregulatory mechanisms of an optimal Chinese herbal monomer compound in mice with allergic rhinitis].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111201

• Astragaloside IV regulates expression of ATP-sensitive potassium channel subunits after ischemia-reperfusion in rat ventricular cardiomyocytes.

  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20111201

• [Effects of astragaloside IV on the expressions of transforming growth factor-β1 and thymic stromal lymphopoietin in a murine model of asthma].

  Zhonghua yi xue za zhi 20111129

• Astragaloside IV attenuates impulse noise-induced trauma in guinea pig.

  Acta oto-laryngologica 20110801

• Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1α accumulation via phosphatidylinositol 3-kinase/Akt pathway.

  The Journal of pharmacology and experimental therapeutics 20110801

• Effect comparison of different formulation of Dang-Gui-Bu-Xu-Tang on myelosuppression mouse.

  Asian Pacific journal of tropical medicine 20110701

• [Determination of astragaloside IV of eight area in Astragali Radix is by HPLC-ELSD internal standard method].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110701

• Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay.

  Sheng li xue bao : [Acta physiologica Sinica] 20110625

• Astragaloside IV protects against ischemia reperfusion in a murine model of orthotopic liver transplantation.

  Transplantation proceedings 20110601

• [Effect of astragaloside against the oxidative damage on endothelial cells].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110601

• Astragaloside IV improves metabolic syndrome and endothelium dysfunction in fructose-fed rats.

  Molecules (Basel, Switzerland) 20110510

• The known immunologically active components of Astragalus account for only a small proportion of the immunological adjuvant activity when combined with conjugate vaccines.

  Planta medica 20110501

• Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy.

  British journal of pharmacology 20110401

• [Simultaneous determination of five glycosides in Aidi injection by RP-HPLC-ELSD].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

• The osteogenetic effect of astragaloside IV with centrifugating pressure on the OCT-1 cells.

  Die Pharmazie 20110101

• [Protective effect of astragalosides on anoxia/reoxygenation injury of hippocampal neuron].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20101101

• Cigarette smoke enhances {beta}-defensin 2 expression in rat airways via nuclear factor-{kappa}B activation.

  The European respiratory journal 20100901

• [Morphological investigation of the protective effect of astragaloside preconditioning against ischemia-reperfusion lung injury in rats].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801

• Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets.

  Fitoterapia 20100701

• Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.

  Planta medica 20100301

• [Study on preventative and curative effects of astragaloside (AST) on mice memory impairment and expression of amyloid precursor protein and beta secretase mRNA induced by dexamethasone].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301

• Effect of astragaloside IV on hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin.

  Phytotherapy research : PTR 20100201

• Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation.

  Biological & pharmaceutical bulletin 20100101

• Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats.

  The American journal of Chinese medicine 20100101

• [Effects of Astragalus injection and its ingredients on proliferation and Akt phosphorylation of breast cancer cell lines].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20091201

• [Inhibitory effect on activated renin-angiotensin system by astragaloside IV in rats with pressure-overload induced cardiac hypertrophy].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

• Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture.

  Neurochemistry international 20091101

• Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products.

  Journal of agricultural and food chemistry 20090909

• Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells.

  Journal of ethnopharmacology 20090421

• Astragaloside IV attenuates hypoxia-induced cardiomyocyte damage in rats by upregulating superoxide dismutase-1 levels.

  Clinical and experimental pharmacology & physiology 20090401

• [Study on the determination method of the astragaloside IV in health food].

  Wei sheng yan jiu = Journal of hygiene research 20090301

• Anti-hepatitis B virus activities of astragaloside IV isolated from radix Astragali.

  Biological & pharmaceutical bulletin 20090101

• Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via alpha3beta1 integrin upregulation and integrin-linked kinase inhibition.

  Biochemical pharmacology 20080915

• Astragaloside IV inhibits proliferation and promotes apoptosis in rat vascular smooth muscle cells under high glucose concentration in vitro.

  Planta medica 20080801

• Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma.

  Canadian journal of physiology and pharmacology 20080701

• [Study on absorption kinetics of astragaloside IV in rats intestines].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701

• Simultaneous determination of calycosin-7-O-beta-D-glucoside, ononin, astragaloside IV, astragaloside I and ferulic acid in rat plasma after oral administration of Danggui Buxue Tang extract for their pharmacokinetic studies by liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080401

• Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide.

  Journal of ethnopharmacology 20080328

• Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca2+ oscillations on hippocampal neurons.

  Acta pharmacologica Sinica 20080101

• Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase.

  Pharmacology 20080101

• [Effects of AST and ASI on metabolism of free radical in senescent rats treated by HC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201

• [Investigation on one-pot extraction of active ingredient group from Yupingfeng powder by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

• Modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside IV in myocardial injury in vivo.

  European journal of pharmacology 20070730

• [Protective effects of Astragaloside and Quercetin on rat myocardial cells after hypoxia].

  Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20070601

• Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings.

  Clinical and experimental pharmacology & physiology 20070101

• [Anti-apoptosis effect of astragaloside on adriamycin induced rat's cardiotoxicity].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20061101

• [The effect of icariin and astragalosid I on the proliferation and differentiation of bone marrow stromal cells].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061001

• Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells.

  Life sciences 20060815

• Simultaneous analysis of seven astragalosides in Radix Astragali and related preparations by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.

  Journal of separation science 20060801

• [Determination of three constituents in Radix Astragali by HPLC-MS].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060801

• Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways.

  Planta medica 20060601

• Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats.

  Canadian journal of physiology and pharmacology 20060601

• [Study on fingerprints of astragalosides injection by HPLC-ELSD].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501

• Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties.

  Journal of agricultural and food chemistry 20060405

• Sensitive and selective liquid chromatography-electrospray ionisation-mass spectrometry analysis of astragaloside-IV in rat plasma.

  Journal of pharmaceutical and biomedical analysis 20060224

• Effects of astragaloside IV on pathogenesis of metabolic syndrome in vitro.

  Acta pharmacologica Sinica 20060201

• Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro.

  Planta medica 20060101

• Absorption enhancement study of astragaloside IV based on its transport mechanism in caco-2 cells.

  European journal of drug metabolism and pharmacokinetics 20060101

• Quantitation of astragaloside IV in rat plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

• Gastroprotective effect of Astragaloside IV: role of prostaglandins, sulfhydryls and nitric oxide.

  The Journal of pharmacy and pharmacology 20050801

• [Study on new extraction technology of astragaloside IV].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050801

• Separation of compounds interacting with liposome membrane in combined prescription of traditional Chinese medicines with immobilized liposome chromatography.

  Journal of pharmaceutical and biomedical analysis 20050615

• Leishmanicidal cycloartane-type triterpene glycosides from Astragalus oleifolius.

  Phytochemistry 20050501

• Effect of astragalosides on intracellular calcium overload in cultured cardiac myocytes of neonatal rats.

  The American journal of Chinese medicine 20050101

• [Studies on chromatography fingerprint of huangqi by HPLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20041101

• [Effect of astrgaloside IV on the long-term consequences of renal ischemia-reperfusion injury in rat].

  Zhonghua yi xue za zhi 20040902

• Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia.

  Neuroscience letters 20040617

• Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression.

  Thrombosis and haemostasis 20031101

• Determination of serum astragaloside in rats fed with Buyanghuanwu dicoction using solidphase extraction, chemical derivatization and fluorospectrophotometry.

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030401

• Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats.

  Acta pharmacologica Sinica 20021001

• Determination of astragaloside IV in Radix astragali (Astragalus membranaceus var. monghulicus) using high-performance liquid chromatography with evaporative light-scattering detection.

  Journal of chromatographic science 20011101

• Antinociceptive effect of astragalosides and its mechanism of action.

  Acta pharmacologica Sinica 20010901