85622-93-1 | 3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide

Packsize	Purity	Availability	Price	Discounted Price
50mg	98%	in stock	$6.00	$4.00
1g	97%	in stock	$26.00	$18.00
5g	97%	in stock	$63.00	$44.00
10g	97%	in stock	$105.00	$74.00
25g	97%	in stock	$180.00	$126.00
100g	97%	in stock	$581.00	$407.00

Description

• Catalog Number: AB50656
• Chemical Name: 3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide
• CAS Number: 85622-93-1
• Molecular Formula: C6H6N6O2
• Molecular Weight: 194.1508
• MDL Number: MFCD00866492
• SMILES: NC(=O)c1ncn2c1nnn(c2=O)C

Computed Properties

• Complexity: 315
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: -1.1

Literature

• Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature.

  Archives of toxicology 20170401

• Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome.

  Oncotarget 20170227

• The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: Summary of the MMS/JEMS-collaborative study across 16 laboratories using 24 chemicals.

  Mutation research 20161115

• OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models.

  International journal of cancer 20161101

• MCM5 as a target of BET inhibitors in thyroid cancer cells.

  Endocrine-related cancer 20160401

• Resveratrol Represses Pokemon Expression in Human Glioma Cells.

  Molecular neurobiology 20160301

• PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway.

  Molecular cancer therapeutics 20151201

• Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM.

  Oncotarget 20151020

• Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy.

  Journal of medicinal chemistry 20150910

• Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft.

  Drug metabolism and disposition: the biological fate of chemicals 20150901

• Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma.

  Toxicology and applied pharmacology 20150715

• Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

  Chemical research in toxicology 20150518

• Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial.

  The Lancet. Oncology 20140901

• The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response.

  Toxicological sciences : an official journal of the Society of Toxicology 20140701

• Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment.

  Toxicology and applied pharmacology 20131215

• Resveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells.

  BMC cancer 20130101

• A phase I study of temozolomide and everolimus (RAD001) in patients with newly diagnosed and progressive glioblastoma either receiving or not receiving enzyme-inducing anticonvulsants: an NCIC CTG study.

  Investigational new drugs 20121201

• Treatment of elderly patients with glioblastoma: from clinical evidence to molecular highlights.

  Cancer treatment reviews 20121201

• Long-term survival in cerebellar glioblastoma multiforme. Case report.

  Journal of neurosurgical sciences 20121201

• MGMT gene promoter methylation as a potent prognostic factor in glioblastoma treated with temozolomide-based chemoradiotherapy: a single-institution study.

  International journal of radiation oncology, biology, physics 20121101

• Phase II trial of radiosurgery to magnetic resonance spectroscopy-defined high-risk tumor volumes in patients with glioblastoma multiforme.

  International journal of radiation oncology, biology, physics 20121101

• Impact of the per-operatory application of GLIADEL wafers (BCNU, carmustine) in combination with temozolomide and radiotherapy in patients with glioblastoma multiforme: efficacy and toxicity.

  Clinical neurology and neurosurgery 20121101

• Phase II trial of hypofractionated IMRT with temozolomide for patients with newly diagnosed glioblastoma multiforme.

  International journal of radiation oncology, biology, physics 20121101

• Olea europaea leaf extract alters microRNA expression in human glioblastoma cells.

  Journal of cancer research and clinical oncology 20121101

• Presentation, management, and outcome of elderly patients with newly-diagnosed anaplastic astrocytoma.

  Journal of neuro-oncology 20121101

• Phase I study of arsenic trioxide and temozolomide in combination with radiation therapy in patients with malignant gliomas.

  Journal of neuro-oncology 20121101

• Diffusion-weighted MR imaging for the differentiation of true progression from pseudoprogression following concomitant radiotherapy with temozolomide in patients with newly diagnosed high-grade gliomas.

  Academic radiology 20121101

• Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents.

  Journal of neurochemistry 20121101

• Chemosensitized radiosurgery for recurrent brain metastases.

  Journal of neuro-oncology 20121101

• Chemotherapy in low-grade gliomas.

  Current opinion in oncology 20121101

• Glioblastoma cell line-derived spheres in serum‑containing medium versus serum-free medium: a comparison of cancer stem cell properties.

  International journal of oncology 20121101

• A single centre study of the treatment of relapsed primary central nervous system lymphoma (PCNSL) with single agent temozolomide.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20121101

• Celecoxib desensitization: continued temozolomide/celecoxib chemotherapy after a celecoxib-induced hypersensitivity reaction.

  Anti-cancer drugs 20121101

• F2A sequence linking MGMT(P140K) and MDR1 in a bicistronic lentiviral vector enables efficient chemoprotection of haematopoietic stem cells.

  Cancer gene therapy 20121101

• A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.

  Pharmacogenetics and genomics 20121101

• Phase I-II study of radiopeptide 177Lu-octreotate in combination with capecitabine and temozolomide in advanced low-grade neuroendocrine tumors.

  Cancer biotherapy & radiopharmaceuticals 20121101

• Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma.

  Cancer letters 20121028

• Enhanced stability and activity of temozolomide in primary glioblastoma multiforme cells with cucurbit[n]uril.

  Chemical communications (Cambridge, England) 20121011

• Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours.

  British journal of cancer 20121009

• NK cell immunotherapy for high-risk neuroblastoma relapse after haploidentical HSCT.

  Pediatric blood & cancer 20121001

• Invasive Mycoleptodiscus fungal cellulitis and myositis.

  Medical mycology 20121001

• Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.

  Cancer 20121001

• A study of clinico-pathological parameters and O⁶-methylguanine DNA methyltransferase (MGMT) promoter methylation status in the prognostication of gliosarcoma.

  Neuropathology : official journal of the Japanese Society of Neuropathology 20121001

• Ex vivo functional analysis, expansion and adoptive transfer of cytomegalovirus-specific T-cells in patients with glioblastoma multiforme.

  Immunology and cell biology 20121001

• Crystal engineering of stable temozolomide cocrystals.

  Chemistry, an Asian journal 20121001

• Side population cells from human melanoma tumors reveal diverse mechanisms for chemoresistance.

  The Journal of investigative dermatology 20121001

• Glioblastoma multiforme imaging: the role of nuclear medicine.

  Current radiopharmaceuticals 20121001

• Change in platelet levels during radiotherapy with concurrent and adjuvant temozolomide for the treatment of glioblastoma: a novel prognostic factor for survival.

  Journal of cancer research and clinical oncology 20121001

• Neuroendocrine tumor disease: an evolving landscape.

  Endocrine-related cancer 20121001

• Steroid-sparing effects of angiotensin-II inhibitors in glioblastoma patients.

  European journal of neurology 20121001

• Chemotherapy and target therapy in the management of adult high- grade gliomas.

  Current cancer drug targets 20121001

• A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma.

  Journal of neuro-oncology 20121001

• Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma.

  Japanese journal of clinical oncology 20121001

• CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.

  Journal of neuro-oncology 20121001

• Therapeutic targeting of VEGF in the treatment of glioblastoma.

  Expert opinion on therapeutic targets 20121001

• ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets.

  Stem cells (Dayton, Ohio) 20121001

• Protracted low dose of oral vinorelbine and temozolomide with whole-brain radiotherapy in the treatment for breast cancer patients with brain metastases.

  Cancer chemotherapy and pharmacology 20121001

• Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells.

  Autophagy 20121001

• Prognosis of patients with multifocal glioblastoma: a case-control study.

  Journal of neurosurgery 20121001

• Beyond ABC: another mechanism of drug resistance in melanoma side population.

  The Journal of investigative dermatology 20121001

• The addition of temozolomide does not change the pattern of progression of glioblastoma multiforme post-radiotherapy.

  Journal of medical imaging and radiation oncology 20121001

• Integrin inhibitor cilengitide for the treatment of glioblastoma: a brief overview of current clinical results.

  Anticancer research 20121001

• The Changes in MGMT Promoter Methylation Status in Initial and Recurrent Glioblastomas.

  Translational oncology 20121001

• BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression.

  Cell death & disease 20121001

• O(6) -methylguanine-DNA methyltransferase (MGMT) promoter methylation and low MGMT-encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery followed by radiotherapy with concomitant and adjuvant temozolomide.

  Cancer 20120915

• Sequence-dependent synergistic inhibition of human glioma cell lines by combined temozolomide and miR-21 inhibitor gene therapy.

  Molecular pharmaceutics 20120904

• Pituitary blastoma: a unique embryonal tumor.

  Pituitary 20120901

• Anti-VEGF therapy in pituitary carcinoma.

  Pituitary 20120901

• MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations.

  International journal of cancer 20120901

• Temozolomide responsiveness in aggressive corticotroph tumours: a case report and review of the literature.

  Pituitary 20120901

• Patterns of imaging failures in glioblastoma patients treated with chemoradiation: a retrospective study.

  Medical oncology (Northwood, London, England) 20120901

• Improving prognosis of glioblastoma in the 21st century: who has benefited most?

  Cancer 20120901

• A clinical review of treatment outcomes in glioblastoma multiforme--the validation in a non-trial population of the results of a randomised Phase III clinical trial: has a more radical approach improved survival?

  The British journal of radiology 20120901

• Glioblastoma: clinical characteristics, prognostic factors and survival in 492 patients.

  Clinical neurology and neurosurgery 20120901

• AZ64 inhibits TrkB and enhances the efficacy of chemotherapy and local radiation in neuroblastoma xenografts.

  Cancer chemotherapy and pharmacology 20120901

• Temozolomide or bevacizumab for spinal cord high-grade gliomas.

  Journal of neuro-oncology 20120901

• Radiotherapy and concomitant temozolomide may improve survival of elderly patients with glioblastoma.

  Journal of neuro-oncology 20120901

• Knockdown of CDK6 enhances glioma sensitivity to chemotherapy.

  Oncology reports 20120901

• Procarbazine, carmustine, and vincristine (PBV) for chemotherapy pre-treated patients with recurrent glioblastoma: a single-institution analysis.

  Journal of neuro-oncology 20120901

• Loss of TP53 expression in immortalized choroid plexus epithelial cells results in increased resistance to anticancer agents.

  Journal of neuro-oncology 20120901

• Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide.

  Journal of neuro-oncology 20120901

• Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells.

  Oncology reports 20120901

• An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120901

• p68 RNA helicase promotes glioma cell proliferation in vitro and in vivo via direct regulation of NF-κB transcription factor p50.

  Neuro-oncology 20120901

• A population-based study on the effect of temozolomide in the treatment of glioblastoma multiforme.

  Neuro-oncology 20120901

• Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial.

  The Lancet. Oncology 20120901

• Glioblastoma therapy in the elderly: one age does not fit all.

  The Lancet. Oncology 20120901

• Overexpression of WW domain-containing oxidoreductase WOX1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120901

• New treatment options with cytotoxic agents in neuroendocrine tumours.

  Targeted oncology 20120901

• Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma.

  American journal of clinical pathology 20120901

• Hypofractionated radiotherapy for glioblastoma: strategy for poor-risk patients or hope for the future?

  The British journal of radiology 20120901

• Temozolomide for relapsed primary CNS lymphoma.

  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20120901

• A review of dose-dense temozolomide alone and in combination with bevacizumab in patients with first relapse of glioblastoma.

  Anticancer research 20120901

• [Use of angioneogenesis inhibitor monoclonal antibody following standard therapy in recurrent or progressive glioblastoma multiforme].

  Magyar onkologia 20120901

• Non-uniform response to temozolomide therapy in a pituitary gonadotroph adenoma.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20120901

• Constitutive Expression of MAP Kinase Phosphatase-1 Confers Multi-drug Resistance in Human Glioblastoma Cells.

  Cancer research and treatment : official journal of Korean Cancer Association 20120901

• Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice.

  Neuro-oncology 20120901

• Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatments.

  Neuro-oncology 20120901

• A restricted cell population propagates glioblastoma growth after chemotherapy.

  Nature 20120823

• Cancer: Resolving the stem-cell debate.

  Nature 20120823

• Prospective study of bevacizumab plus temozolomide in patients with advanced neuroendocrine tumors.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120820

• Differential effects of the glycolysis inhibitor 2-deoxy-D-glucose on the activity of pro-apoptotic agents in metastatic melanoma cells, and induction of a cytoprotective autophagic response.

  International journal of cancer 20120815

• Potentiation of etoposide and temozolomide cytotoxicity by curcumin and turmeric force™ in brain tumor cell lines.

  Journal of complementary & integrative medicine 20120810

• O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems.

  Biochimica et biophysica acta 20120801

• Cilengitide in bevacizumab-refractory high-grade glioma: two case reports and critical review of the literature.

  Anti-cancer drugs 20120801

• A multicenter prospective observational study of the conformity of temozolomide prescriptions in France.

  Pharmacoepidemiology and drug safety 20120801

• Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas.

  The American journal of surgical pathology 20120801

• Treatment-related toxicities in tumor-bearing cats treated with temozolomide alone or in combination with doxorubicin: a pilot assessment.

  Journal of feline medicine and surgery 20120801

• Efficacy of clinically relevant temozolomide dosing schemes in glioblastoma cancer stem cell lines.

  Journal of neuro-oncology 20120801

• Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model.

  Biomaterials 20120801

• Phase II trial of temozolomide for leptomeningeal metastases in patients with solid tumors.

  Journal of neuro-oncology 20120801

• Predictive value of the MGMT promoter methylation status in metastatic melanoma patients receiving first-line temozolomide plus bevacizumab in the trial SAKK 50/07.

  Oncology reports 20120801

• In vivo selection of autologous MGMT gene-modified cells following reduced-intensity conditioning with BCNU and temozolomide in the dog model.

  Cancer gene therapy 20120801

• Waiting times before initiation of radiotherapy might not affect outcomes for patients with glioblastoma: a French retrospective analysis of patients treated in the era of concomitant temozolomide and radiotherapy.

  Journal of neuro-oncology 20120801

• Anaplastic glioma.

  Current treatment options in neurology 20120801

• Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120801

• Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent glioblastoma.

  Acta neurochirurgica 20120801

• Quantitative proteomic analysis and functional studies reveal that nucleophosmin is involved in cell death in glioblastoma cell line transfected with siRNA.

  Proteomics 20120801

• Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer.

  Bioorganic & medicinal chemistry 20120801

• Recent innovations in the management of low-grade gliomas.

  Current treatment options in neurology 20120801

• N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents.

  Cell research 20120801

• N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis.

  European journal of medicinal chemistry 20120801

• Does neurologic deterioration help to differentiate between pseudoprogression and true disease progression in newly diagnosed glioblastoma multiforme?

  Current oncology (Toronto, Ont.) 20120801

• Bevacizumab as first-line therapy for glioblastoma.

  Future oncology (London, England) 20120801

• Role for cytotoxic chemotherapy in patients with recurrent glioblastoma progressing on bevacizumab: a retrospective case series.

  Expert review of neurotherapeutics 20120801

• Temozolomide during and after Radiotherapy for Newly Diagnosed Glioblastomas : A Prospective Multicenter Study of Korean Patients.

  Journal of Korean Neurosurgical Society 20120801

• Late and prolonged pseudoprogression in glioblastoma after treatment with lomustine and temozolomide.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720

• Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro.

  Oncogene 20120719

• In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines.

  International journal of cancer 20120715

• Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma.

  Cancer research 20120715

• Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120715

• Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents.

  International journal of cancer 20120701

• Effects of chemotherapeutics on organotypic corticostriatal slice cultures identified by a panel of fluorescent and immunohistochemical markers.

  Neurotoxicity research 20120701

• Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments.

  Journal of cellular biochemistry 20120701

• Key concepts in glioblastoma therapy.

  Journal of neurology, neurosurgery, and psychiatry 20120701

• Treatment of a solid tumor using engineered drug-resistant immunocompetent cells and cytotoxic chemotherapy.

  Human gene therapy 20120701

• Impact of antiepileptic drugs on thrombocytopenia in glioblastoma patients treated with standard chemoradiotherapy.

  Journal of neuro-oncology 20120701

• Bevacizumab is an active agent for recurrent high-grade glioma, but do we need randomized controlled trials?

  Anti-cancer drugs 20120701

• Results of phase I study of a multi-modality treatment for newly diagnosed glioblastoma multiforme using local implantation of concurrent BCNU wafers and permanent I-125 seeds followed by fractionated radiation and temozolomide chemotherapy.

  Journal of neuro-oncology 20120701

• Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma.

  International journal of pharmaceutics 20120701

• Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms.

  Molecular medicine reports 20120701

• Cerebral ganglioneuroblastoma of adult onset: two patients and a review of the literature.

  Clinical neurology and neurosurgery 20120701

• Fatal pneumonia associated with temozolomide therapy in patients with malignant glioma.

  Japanese journal of clinical oncology 20120701

• Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway.

  CNS neuroscience & therapeutics 20120701

• Drug-induced cholestatic hepatitis: how late can it occur even after the cessation of the culpable drug?

  Neuro-oncology 20120701

• Prognosis of pediatric high-grade gliomas with temozolomide treatment: a retrospective, multicenter study.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20120701

• Treatment of elderly patients with glioblastoma.

  The Lancet. Oncology 20120701

• Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.

  The Lancet. Oncology 20120701

• New substituted 4H-chromenes as anticancer agents.

  Bioorganic & medicinal chemistry letters 20120701

• Bevacizumab plus irinotecan in recurrent malignant glioma shows high overall survival in a multicenter retrospective pooled series of the Spanish Neuro-Oncology Research Group (GEINO).

  Anti-cancer drugs 20120701

• The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas.

  Cancer chemotherapy and pharmacology 20120701

• Assessment of treatment response in patients with glioblastoma using O-(2-18F-fluoroethyl)-L-tyrosine PET in comparison to MRI.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120701

• FET-PET assessed recurrence pattern after radio-chemotherapy in newly diagnosed patients with glioblastoma is influenced by MGMT methylation status.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20120701

• Potential usefulness of radiosensitizers in glioblastoma.

  Neurosurgery clinics of North America 20120701

• MicroRNA-21 inhibition enhances in vitro chemosensitivity of temozolomide-resistant glioblastoma cells.

  Anticancer research 20120701

• New molecularly targeted therapies for glioblastoma multiforme.

  Anticancer research 20120701

• Chemotherapy-associated steatohepatitis with temozolomide and dexamethasone.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20120701

• Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones.

  Biochemical pharmacology 20120615

• Pseudoprogression in patients with glioblastoma multiforme after concurrent radiotherapy and temozolomide.

  American journal of clinical oncology 20120601

• MRI and thallium-201 SPECT in the prediction of survival in glioma.

  Neuroradiology 20120601

• Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis.

  International journal of clinical oncology 20120601

• Temozolomide plus radiotherapy for glioblastoma in a Canadian province: efficacy versus effectiveness and the impact of O6-methylguanine-DNA-methyltransferase promoter methylation.

  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20120601

• Effect of valproic acid on the outcome of glioblastoma multiforme.

  British journal of neurosurgery 20120601

• Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial.

  Acta neuropathologica 20120601

• Factors affecting the cerebral network in brain tumor patients.

  Journal of neuro-oncology 20120601

• Cognition and resective surgery for diffuse infiltrative glioma: an overview.

  Journal of neuro-oncology 20120601

• Temozolomide in the management of dopamine agonist-resistant prolactinomas.

  Clinical endocrinology 20120601

• Pituitary carcinomas and aggressive pituitary tumours: merits and pitfalls of temozolomide treatment.

  Clinical endocrinology 20120601

• Resveratrol reverses temozolomide resistance by downregulation of MGMT in T98G glioblastoma cells by the NF-κB-dependent pathway.

  Oncology reports 20120601

• Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system.

  Biomaterials 20120601

• A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine.

  European journal of endocrinology 20120601

• Pancreatic neuroendocrine and carcinoid tumors: what's new, what's old, and what's different?

  Current oncology reports 20120601

• Temozolomide dosing regimens for glioma patients.

  Current neurology and neuroscience reports 20120601

• SSBP2 variants are associated with survival in glioblastoma patients.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120601

• Long-term control of a MEN1 prolactin secreting pituitary carcinoma after temozolomide treatment.

  Annales d'endocrinologie 20120601

• MicroRNA-21 inhibitor sensitizes human glioblastoma U251 stem cells to chemotherapeutic drug temozolomide.

  Journal of molecular neuroscience : MN 20120601

• STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression.

  Molecular cancer therapeutics 20120601

• Radiotherapy and temozolomide in anaplastic astrocytoma: a retrospective multicenter study by the Central Nervous System Study Group of AIRO (Italian Association of Radiation Oncology).

  Neuro-oncology 20120601

• miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression.

  Neuro-oncology 20120601

• Initial treatment patterns over time for anaplastic oligodendroglial tumors.

  Neuro-oncology 20120601

• Combination hyperbaric oxygen and temozolomide therapy in C6 rat glioma model.

  Acta cirurgica brasileira 20120601

• Systemic therapy for advanced pancreatic neuroendocrine tumors: an update.

  Journal of the National Comprehensive Cancer Network : JNCCN 20120601

• Management of glioblastoma in the elderly.

  Clinical advances in hematology & oncology : H&O 20120601

• Challenges in drug delivery to tumors of the central nervous system: an overview of pharmacological and surgical considerations.

  Advanced drug delivery reviews 20120515

• Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma.

  International journal of radiation oncology, biology, physics 20120501

• Whole abdominopelvic intensity-modulated radiation therapy for desmoplastic small round cell tumor after surgery.

  International journal of radiation oncology, biology, physics 20120501

• An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing.

  Journal of neuro-oncology 20120501

• Recent advances in the molecular understanding of glioblastoma.

  Journal of neuro-oncology 20120501

• Prognostic significance of MRP5 immunohistochemical expression in glioblastoma.

  Cancer chemotherapy and pharmacology 20120501

• Prospective cohort study of radiotherapy with concomitant and adjuvant temozolomide chemotherapy for glioblastoma patients with no or minimal residual enhancing tumor load after surgery.

  Journal of neuro-oncology 20120501

• CXCL12 mediates apoptosis resistance in rat C6 glioma cells.

  Oncology reports 20120501

• Marked response of gliomatosis cerebri to temozolomide and whole brain radiotherapy.

  Clinical neurology and neurosurgery 20120501

• Myc proteins in brain tumor development and maintenance.

  Upsala journal of medical sciences 20120501

• Extended adjuvant temozolomide for treatment of newly diagnosed glioblastoma multiforme.

  Journal of neuro-oncology 20120501

• The effects of temozolomide delivered by prolonged intracerebral microinfusion against the rat brainstem GBM allograft model.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20120501

• Severe sustained cholestatic hepatitis following temozolomide in a patient with glioblastoma multiforme: case study and review of data from the FDA adverse event reporting system.

  Neuro-oncology 20120501

• Dose dense 1 week on/1 week off temozolomide in recurrent glioma: a retrospective study.

  Journal of neuro-oncology 20120501

• Successful pregnancy and delivery after concomitant temozolomide and radiotherapy treatment of glioblastoma multiforme.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20120501

• Treatment-related myelodysplasia in patients with primary brain tumors.

  Neuro-oncology 20120501

• In vitro evaluation of combined temozolomide and radiotherapy using X  rays and high-linear energy transfer radiation for glioblastoma.

  Radiation research 20120501

• Neural stem cells: brain building blocks and beyond.

  Upsala journal of medical sciences 20120501

• Glioblastoma--a moving target.

  Upsala journal of medical sciences 20120501

• Possible differentiation of cerebral glioblastoma into pleomorphic xanthoastrocytoma: an unusual case in an infant.

  Journal of neurosurgery. Pediatrics 20120501

• Phase 2 trial design in neuro-oncology revisited: a report from the RANO group.

  The Lancet. Oncology 20120501

• [Genetic alterations and biomarkers for glioma].

  Brain and nerve = Shinkei kenkyu no shinpo 20120501

• Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation.

  PLoS biology 20120501

• Molecular mechanisms of temozolomide resistance in glioblastoma multiforme.

  Expert review of anticancer therapy 20120501

• Radiation necrosis of a high-grade glioma.

  Medicine and health, Rhode Island 20120501

• Adult glioblastoma multiforme survival in the temozolomide era: a population-based analysis of Surveillance, Epidemiology, and End Results registries.

  Cancer 20120415

• 3'-5' phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo.

  The Biochemical journal 20120415

• Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.

  Journal of medicinal chemistry 20120412

• A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial.

  Investigational new drugs 20120401

• Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas.

  International journal of radiation oncology, biology, physics 20120401

• The concepts, diagnosis and management of early imaging changes after therapy for glioblastomas.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20120401

• Cerebellar gliomatosis in a toddler: case report of a challenging condition and review of the literature.

  Journal of child neurology 20120401

• Glioblastoma survival in the United States before and during the temozolomide era.

  Journal of neuro-oncology 20120401

• Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study.

  Journal of neuro-oncology 20120401

• Spinal cord glioneuronal tumor with neuropil-like islands with 1p/19q deletion in an adult with low-grade cerebral oligodendroglioma.

  Journal of neuro-oncology 20120401

• High levels of cellular proliferation predict pseudoprogression in glioblastoma patients.

  International journal of oncology 20120401

• Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor.

  Journal of neuro-oncology 20120401

• Hypofractionated radiotherapy with or without concurrent temozolomide in elderly patients with glioblastoma multiforme: a review of ten-year single institutional experience.

  Journal of neuro-oncology 20120401

• Going past the data for temozolomide.

  Cancer chemotherapy and pharmacology 20120401

• Complete remission after bevacizumab plus temozolomide in a patient with recurrent glioblastoma multiforme.

  Acta oncologica (Stockholm, Sweden) 20120401

• Temozolomide for pediatric high-grade gliomas.

  Current neurology and neuroscience reports 20120401

• Responsive fluorescent Bi(2)O(3)@PVA hybrid nanogels for temperature-sensing, dual-modal imaging, and drug delivery.

  Biomaterials 20120401

• PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma.

  Cancer research 20120401

• Phase I study of terameprocol in patients with recurrent high-grade glioma.

  Neuro-oncology 20120401

• Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.

  Neuro-oncology 20120401

• Pseudoprogression and treatment effect.

  Neurosurgery clinics of North America 20120401

• Alternative chemotherapeutic agents: nitrosoureas, cisplatin, irinotecan.

  Neurosurgery clinics of North America 20120401

• Temozolomide and other potential agents for the treatment of glioblastoma multiforme.

  Neurosurgery clinics of North America 20120401

• Superselective intra-arterial cerebral infusion of novel agents after blood-brain disruption for the treatment of recurrent glioblastoma multiforme: a technical case series.

  Neurosurgery clinics of North America 20120401

• The role of avastin in the management of recurrent glioblastoma.

  Neurosurgery clinics of North America 20120401

• Temozolomide-associated bronchiolitis obliterans organizing pneumonia successfully treated with high-dose corticosteroid.

  Journal of Korean medical science 20120401

• Decreased expression of the augmenter of liver regeneration results in increased apoptosis and oxidative damage in human-derived glioma cells.

  Cell death & disease 20120401

• Radiotherapy with concurrent or sequential temozolomide in elderly patients with glioblastoma multiforme.

  Journal of medical imaging and radiation oncology 20120401

• Treatment of nonfunctioning pituitary adenomas: what were the contributions of the last 10 years? A critical view.

  Annales d'endocrinologie 20120401

• Matrix metalloproteinase-2 and -9 in glioblastoma: a trio of old drugs-captopril, disulfiram and nelfinavir-are inhibitors with potential as adjunctive treatments in glioblastoma.

  Archives of medical research 20120401

• Temozolomide in aggressive pituitary adenomas and carcinomas.

  Clinics (Sao Paulo, Brazil) 20120401

• Phase II study of concurrent radiation therapy, temozolomide, and bevacizumab followed by bevacizumab/everolimus as first-line treatment for patients with glioblastoma.

  Clinical advances in hematology & oncology : H&O 20120401

• Helping patients make the best decision regarding duration of temozolomide chemotherapy treatment.

  Continuum (Minneapolis, Minn.) 20120401

• Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control.

  Cell cycle (Georgetown, Tex.) 20120315

• Oxaphosphinanes: new therapeutic perspectives for glioblastoma.

  Journal of medicinal chemistry 20120308

• Failure of temozolomide and conventional doses of pegvisomant to attain biochemical control in a severe case of acromegaly.

  Pituitary 20120301

• Response to temozolomide and bevacizumab in a patient with poorly differentiated neuroendocrine carcinoma.

  Medical oncology (Northwood, London, England) 20120301

• Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas.

  International journal of cancer 20120301

• Bevacizumab and daily temozolomide for recurrent glioblastoma.

  Cancer 20120301

• New targeted therapies in pituitary carcinoma resistant to temozolomide.

  Pituitary 20120301

• O⁶-methylguanine-DNA methyltransferase promoter methylation in 45 primary central nervous system lymphomas: quantitative assessment of methylation and response to temozolomide treatment.

  Journal of neuro-oncology 20120301

• Protein alterations associated with temozolomide resistance in subclones of human glioblastoma cell lines.

  Journal of neuro-oncology 20120301

• Improved survival time trends for glioblastoma using the SEER 17 population-based registries.

  Journal of neuro-oncology 20120301

• Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation.

  Journal of neuro-oncology 20120301

• Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status.

  Oncology reports 20120301

• Therapeutical doses of temozolomide do not impair the function of dendritic cells and CD8+ T cells.

  International journal of oncology 20120301

• Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma.

  Neuro-oncology 20120301

• Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells.

  Journal of cancer research and clinical oncology 20120301

• Anti-angiogenic approaches to malignant gliomas.

  Current cancer drug targets 20120301

• Patterns of care and survival for patients with glioblastoma multiforme diagnosed during 2006.

  Neuro-oncology 20120301

• Targeted therapy for brain tumours: role of PARP inhibitors.

  Current cancer drug targets 20120301

• Functional diffusion maps (fDMs) evaluated before and after radiochemotherapy predict progression-free and overall survival in newly diagnosed glioblastoma.

  Neuro-oncology 20120301

• A phase I study of LY317615 (enzastaurin) and temozolomide in patients with gliomas (EORTC trial 26054).

  Neuro-oncology 20120301

• Murine models and cell lines for the investigation of pheochromocytoma: applications for future therapies?

  Endocrine pathology 20120301

• Pituitary carcinoma recurrent to the lumbar intradural extramedullary space: case report.

  The journal of spinal cord medicine 20120301

• Adult brainstem gliomas.

  The oncologist 20120301

• Twice-daily dosing of temozolomide in combination with fotemustine for the treatment of patients with refractory glioblastoma.

  Anticancer research 20120301

• The expression of p-STAT3 in stage IV melanoma: risk of CNS metastasis and survival.

  Oncotarget 20120301

• Extraneural metastasis of glioblastoma multiforme presenting as an unusual neck mass.

  Journal of Korean Neurosurgical Society 20120301

• Autophagy and cancer.

  Experimental & molecular medicine 20120227

• The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models.

  British journal of cancer 20120227

• Progression-free and overall survival in patients with relapsed/refractory germ cell tumors treated with single-agent chemotherapy: endpoints for clinical trial design.

  Cancer 20120215

• Phase II trial of temozolomide in patients with relapsed sensitive or refractory small cell lung cancer, with assessment of methylguanine-DNA methyltransferase as a potential biomarker.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120215

• Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120215

• Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas.

  Oncogene 20120209

• A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme.

  International journal of radiation oncology, biology, physics 20120201

• Retrospective comparison of chemoradiotherapy followed by adjuvant chemotherapy, with or without prior gliadel implantation (carmustine) after initial surgery in patients with newly diagnosed high-grade gliomas.

  International journal of radiation oncology, biology, physics 20120201

• Phase I clinical trial assessing temozolomide and tamoxifen with concomitant radiotherapy for treatment of high-grade glioma.

  International journal of radiation oncology, biology, physics 20120201

• First-line temozolomide combined with bevacizumab in metastatic melanoma: a multicentre phase II trial (SAKK 50/07).

  Annals of oncology : official journal of the European Society for Medical Oncology 20120201

• O-6-methylguanine-DNA methyltransferase (MGMT) immunohistochemical expression in pituitary corticotroph adenomas.

  Neurosurgery 20120201

• A phase I study of bortezomib and temozolomide in patients with advanced solid tumors.

  Cancer chemotherapy and pharmacology 20120201

• A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study.

  Journal of neuro-oncology 20120201

• New treatment strategies in advanced neuroendocrine tumours.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20120201

• Efficacy and toxicity of CyberKnife re-irradiation and 'dose dense' temozolomide for recurrent gliomas.

  Acta neurochirurgica 20120201

• Prognostic factors and survival in a prospective cohort of patients with high-grade glioma treated with carmustine wafers or temozolomide on an intention-to-treat basis.

  Acta neurochirurgica 20120201

• IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma.

  Cancer science 20120201

• Avastin: more questions than answers. .

  Journal of neurosurgery 20120201

• A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma.

  Journal of neurosurgery 20120201

• LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway.

  Molecular medicine reports 20120201

• Outcome, quality of life and cognitive function of patients with brain metastases from non-small cell lung cancer treated with whole brain radiotherapy combined with gefitinib or temozolomide. A randomised phase II trial of the Swiss Group for Clinical Cancer Research (SAKK 70/03).

  European journal of cancer (Oxford, England : 1990) 20120201

• Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI.

  Biomaterials 20120201

• Gastroenteropancreatic neuroendocrine tumors: new insights in the diagnosis and therapy.

  Endocrine 20120201

• Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor.

  Molecular cancer therapeutics 20120201

• Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.

  Nature genetics 20120201

• Reoxygenation of glioblastoma multiforme treated with fractionated radiotherapy concomitant with temozolomide: changes defined by 18F-fluoromisonidazole positron emission tomography: two case reports.

  Japanese journal of clinical oncology 20120201

• Low-dosage metronomic chemotherapy and angiogenesis: topoisomerase inhibitors irinotecan and mitoxantrone stimulate VEGF-A-mediated angiogenesis.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20120201

• Radiotherapy with and without temozolomide in elderly patients with glioblastoma.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20120201

• Combination treatment with metronomic temozolomide, bevacizumab and long-acting octreotide for malignant neuroendocrine tumours.

  Endocrine-related cancer 20120201

• [Retrospective analysis of 24 recurrent glioblastoma after chemoradiation and treated with nitrosoureas or irinotecan and bevacizumab].

  Bulletin du cancer 20120201

• Whole-brain irradiation with concomitant daily fixed-dose temozolomide for brain metastases treatment: a randomised phase II trial.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20120201

• [Analyses of IDH1 mutation and MGMT promoter methylation status for 5 cases of long-term survivors with glioblastoma].

  No shinkei geka. Neurological surgery 20120201

• [Comparison of two regimens of postoperative concurrent chemoradiotherapy in adult patients with grade III-IV cerebral gliomas].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120201

• Glioblastoma following radiosurgery for meningioma.

  Journal of Korean Neurosurgical Society 20120201

• Polymodal therapy for high grade gliomas: a case report of favourable outcomes following intraoperative radiation therapy.

  The Medical journal of Malaysia 20120201

• PARP-1 protein expression in glioblastoma multiforme.

  European journal of histochemistry : EJH 20120120

• TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells.

  International journal of cancer 20120115

• Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120115

• Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy.

  Free radical biology & medicine 20120115

• Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120115

• Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.

  Journal of the National Cancer Institute 20120104

• Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.

  The Journal of clinical investigation 20120103

• Developing and paying for medicines for orphan indications in oncology: utilitarian regulation vs equitable care?

  British journal of cancer 20120103

• Enhancing melanoma treatment with resveratrol.

  The Journal of surgical research 20120101

• Irradiation and bevacizumab in high-grade glioma retreatment settings.

  International journal of radiation oncology, biology, physics 20120101

• Phase I dose escalation trial of vandetanib with fractionated radiosurgery in patients with recurrent malignant gliomas.

  International journal of radiation oncology, biology, physics 20120101

• Addition of bevacizumab to standard radiation therapy and daily temozolomide is associated with minimal toxicity in newly diagnosed glioblastoma multiforme.

  International journal of radiation oncology, biology, physics 20120101

• Hematologic adverse events associated with temozolomide.

  Cancer chemotherapy and pharmacology 20120101

• Salvage treatment with temozolomide in refractory or relapsed primary central nervous system lymphoma and assessment of the MGMT status.

  Journal of neuro-oncology 20120101

• Prolonged temozolomide for treatment of glioblastoma: preliminary clinical results and prognostic value of p53 overexpression.

  Journal of neuro-oncology 20120101

• Intravenous administration of temozolomide as a useful alternative over oral treatment with temozolomide capsules in patients with gliomas.

  Journal of neuro-oncology 20120101

• Combination of neoadjuvant chemotherapy followed by surgical resection as a new strategy for WHO grade II gliomas: a study of cognitive status and quality of life.

  Journal of neuro-oncology 20120101

• Antiangiogenic therapy for patients with recurrent and newly diagnosed malignant gliomas.

  Journal of oncology 20120101

• Anaplastic ependymoma simulating glioblastoma in the cerebrum of an adult.

  Brain tumor pathology 20120101

• Type 2 diabetes mellitus and obesity are independent risk factors for poor outcome in patients with high-grade glioma.

  Journal of neuro-oncology 20120101

• Subcutaneous tumor seeding after biopsy in gliomatosis cerebri.

  Journal of neuro-oncology 20120101

• Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma.

  Journal of neuro-oncology 20120101

• Temozolomide in relapsed pediatric brain tumors: 14 cases from a single center.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20120101

• MicroRNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis.

  International journal of oncology 20120101

• Chemoresistance to temozolomide in human glioma cell line U251 is associated with increased activity of O6-methylguanine-DNA methyltransferase and can be overcome by metronomic temozolomide regimen.

  Cell biochemistry and biophysics 20120101

• The Role of PTEN in Tumor Angiogenesis.

  Journal of oncology 20120101

• Tetraarsenic Hexoxide Induces Beclin-1-Induced Autophagic Cell Death as well as Caspase-Dependent Apoptosis in U937 Human Leukemic Cells.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Novel medical therapies of recurrent and metastatic gastroenteropancreatic neuroendocrine tumors.

  Digestive diseases and sciences 20120101

• Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents.

  Pigment cell & melanoma research 20120101

• New criteria for analyzing the statistical relationships between biological parameters and therapeutic responses of xenografted tumor models.

  Contemporary clinical trials 20120101

• Low-dose fractionated radiotherapy and concomitant chemotherapy in glioblastoma multiforme with poor prognosis: a feasibility study.

  Neuro-oncology 20120101

• Ipilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma?

  Dermatology research and practice 20120101

• Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome.

  Biomaterials 20120101

• Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs).

  Gut 20120101

• Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemia.

  American journal of hematology 20120101

• Concurrent temozolomide and dose-escalated intensity-modulated radiation therapy in newly diagnosed glioblastoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120101

• Basal breast cancer: a complex and deadly molecular subtype.

  Current molecular medicine 20120101

• Biomarkers as key contributors in treating malignant melanoma metastases.

  Dermatology research and practice 20120101

• Evolving drug targets in DNA base excision repair for cancer therapy.

  Current molecular pharmacology 20120101

• Overview of base excision repair biochemistry.

  Current molecular pharmacology 20120101

• Temozolomide: mechanisms of action, repair and resistance.

  Current molecular pharmacology 20120101

• Bevacizumab in glioblastoma multiforme.

  Expert review of anticancer therapy 20120101

• Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug.

  Journal of biomedicine & biotechnology 20120101

• Fluctuation of systemic immunity in melanoma and implications for timing of therapy.

  Frontiers in bioscience (Elite edition) 20120101

• Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging.

  International journal of medical sciences 20120101

• Volumetric and MGMT parameters in glioblastoma patients: survival analysis.

  BMC cancer 20120101

• Targeting the Cellular Signaling: BRAF Inhibition and Beyond for the Treatment of Metastatic Malignant Melanoma.

  Dermatology research and practice 20120101

• Successful treatment of leptomeningeal gliomatosis of pilomyxoid astrocytoma after failed frontline chemotherapy.

  The neurologist 20120101

• Neurological complications of chemotherapy to the central nervous system.

  Handbook of clinical neurology 20120101

• Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1.

  Journal of translational medicine 20120101

• Ovarian cancer: opportunity for targeted therapy.

  Journal of oncology 20120101

• Glucosylceramide synthase protects glioblastoma cells against autophagic and apoptotic death induced by temozolomide and Paclitaxel.

  Cancer investigation 20120101

• Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.

  Cell death & disease 20120101

• Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.

  PloS one 20120101

• A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis.

  PLoS computational biology 20120101

• Eosinophils in glioblastoma biology.

  Journal of neuroinflammation 20120101

• Aflibercept in the treatment of metastatic colorectal cancer.

  Clinical Medicine Insights. Oncology 20120101

• Novel treatments for metastatic cutaneous melanoma and the management of emergent toxicities.

  Clinical Medicine Insights. Oncology 20120101

• Prediction of glioblastoma multiform response to bevacizumab treatment using multi-parametric MRI.

  PloS one 20120101

• Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.

  PloS one 20120101

• Methylation status of O6-methylguanine-DNA-methyl transferase promoter region in non-small-cell lung cancer patients with brain metastasis.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20120101

• Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas.

  Diagnostic pathology 20120101

• Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy.

  Theranostics 20120101

• Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models.

  Oncotarget 20120101

• Status quo--standard-of-care medical and radiation therapy for glioblastoma.

  Cancer journal (Sudbury, Mass.) 20120101

• Neuroimaging: diagnosis and response assessment in glioblastoma.

  Cancer journal (Sudbury, Mass.) 20120101

• Monoclonal antibodies and Fc fragments for treating solid tumors.

  Biologics : targets & therapy 20120101

• Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China.

  PloS one 20120101

• Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.

  PloS one 20120101

• Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer.

  International journal of breast cancer 20120101

• Neoplastic cells are a rare component in human glioblastoma microvasculature.

  Oncotarget 20120101

• The effect of temozolomide/poly(lactide-co-glycolide) (PLGA)/nano-hydroxyapatite microspheres on glioma U87 cells behavior.

  International journal of molecular sciences 20120101

• Modulation of tumor tolerance in primary central nervous system malignancies.

  Clinical & developmental immunology 20120101

• Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells.

  Stem cell research & therapy 20120101

• Current management and novel agents for malignant melanoma.

  Journal of hematology & oncology 20120101

• Sendai virus-based liposomes enable targeted cytosolic delivery of nanoparticles in brain tumor-derived cells.

  Journal of nanobiotechnology 20120101

• The monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab, in the treatment of melanoma.

  Cancer management and research 20120101

• Treatment Options in Cushing's Disease.

  Clinical Medicine Insights. Oncology 20120101

• Implementing preclinical study findings to protocol design: translational studies with alloreactive CTL for gliomas.

  American journal of translational research 20120101

• Cord blood stem cells inhibit epidermal growth factor receptor translocation to mitochondria in glioblastoma.

  PloS one 20120101

• A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.

  PloS one 20120101

• Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.

  PloS one 20120101

• Therapy for metastatic melanoma: the past, present, and future.

  BMC medicine 20120101

• Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.

  PloS one 20120101

• MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR.

  Journal of translational medicine 20120101

• Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment.

  PloS one 20120101

• Iodine-125 brachytherapy for brain tumours--a review.

  Radiation oncology (London, England) 20120101

• Toxin-based targeted therapy for malignant brain tumors.

  Clinical & developmental immunology 20120101

• β-Catenin Signalling in Glioblastoma Multiforme and Glioma-Initiating Cells.

  Chemotherapy research and practice 20120101

• Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours.

  Chemotherapy research and practice 20120101

• Detection of 1p19q deletion by real-time comparative quantitative PCR.

  Biomarker insights 20120101

• In vitro and in vivo studies on gelatin-siloxane nanoparticles conjugated with SynB peptide to increase drug delivery to the brain.

  International journal of nanomedicine 20120101

• Nanomedicine: towards development of patient-friendly drug-delivery systems for oncological applications.

  International journal of nanomedicine 20120101

• The limitations of locus specific methylation qualification and quantification in clinical material.

  Frontiers in genetics 20120101

• Intra-arterial delivery of bevacizumab after blood-brain barrier disruption for the treatment of recurrent glioblastoma: progression-free survival and overall survival.

  World neurosurgery 20120101

• RGD-conjugated gold nanorods induce radiosensitization in melanoma cancer cells by downregulating α(v)β₃ expression.

  International journal of nanomedicine 20120101

• PTEN as a prognostic and predictive marker in postoperative radiotherapy for squamous cell cancer of the head and neck.

  PloS one 20120101

• Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine.

  OncoTargets and therapy 20120101

• Targeted agents for the treatment of metastatic melanoma.

  OncoTargets and therapy 20120101

• Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.

  Frontiers in pharmacology 20120101

• Pediatric cerebellar hemorrhagic glioblastoma multiforme.

  The open neuroimaging journal 20120101

• Low levels of Human Cytomegalovirus Infection in Glioblastoma multiforme associates with patient survival; -a case-control study.

  Herpesviridae 20120101

• Co-deletion of chromosome 1p/19q and IDH1/2 mutation in glioma subsets of brain tumors in Chinese patients.

  PloS one 20120101

• Topical application of activity-based probes for visualization of brain tumor tissue.

  PloS one 20120101

• Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma.

  PloS one 20120101

• The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond.

  TheScientificWorldJournal 20120101

• NF-κB as potential target in the treatment of melanoma.

  Journal of translational medicine 20120101

• Proton and carbon ion radiotherapy for primary brain tumors delivered with active raster scanning at the Heidelberg Ion Therapy Center (HIT): early treatment results and study concepts.

  Radiation oncology (London, England) 20120101

• Efficacy and tolerability of lapatinib in the management of breast cancer.

  Breast cancer : basic and clinical research 20120101

• Comparison of intensity modulated radiotherapy (IMRT) with intensity modulated particle therapy (IMPT) using fixed beams or an ion gantry for the treatment of patients with skull base meningiomas.

  Radiation oncology (London, England) 20120101

• Classification, molecular characterization, and the significance of pten alteration in leiomyosarcoma.

  Sarcoma 20120101

• Atypical, invasive, recurring Crooke cell adenoma of the pituitary.

  Hormones (Athens, Greece) 20120101

• Association between a Primitive Brain Tumor and Cerebral Aspergillosis.

  Case reports in medicine 20120101

• Use of a deformable atlas to identify cryptic critical structures in the treatment of glioblastoma multiforme.

  PloS one 20120101

• Glioblastoma multiforme: novel therapeutic approaches.

  ISRN neurology 20120101

• Monitoring of patients treated with particle therapy using positron-emission-tomography (PET): the MIRANDA study.

  BMC cancer 20120101

• Cellular-based immunotherapies for patients with glioblastoma multiforme.

  Clinical & developmental immunology 20120101

• Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era.

  PloS one 20120101

• Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival.

  Molecular cancer 20120101

• An observational study of the first experience with bevacizumab for the treatment of patients with recurrent high-grade glioma in two belgian university hospitals.

  Journal of oncology 20120101

• Akt: a double-edged sword in cell proliferation and genome stability.

  Journal of oncology 20120101

• Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients.

  PloS one 20120101

• Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death.

  PloS one 20120101

• In vitro and in vivo antagonism of a G protein-coupled receptor (S1P3) with a novel blocking monoclonal antibody.

  PloS one 20120101

• CD24 expression as a marker for predicting clinical outcome in human gliomas.

  Journal of biomedicine & biotechnology 20120101

• Targeting costimulatory molecules to improve antitumor immunity.

  Journal of biomedicine & biotechnology 20120101

• The ketogenic diet as a treatment paradigm for diverse neurological disorders.

  Frontiers in pharmacology 20120101

• Subgroup economic analysis for glioblastoma in a health resource-limited setting.

  PloS one 20120101

• Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization In Vitro.

  Journal of Cancer 20120101

• Contribution of low-molecular weight heparin addition to concomitant chemoradiotherapy in the treatment of glioblastoma multiforme.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20120101

• Treatment of liver metastases in patients with neuroendocrine tumors of gastroesophageal and pancreatic origin.

  International journal of hepatology 20120101

• A multimodal approach to the management of neuroendocrine tumour liver metastases.

  International journal of hepatology 20120101

• A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma.

  PloS one 20120101

• The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries.

  Journal of signal transduction 20120101

• miRNAs expression analysis in paired fresh/frozen and dissected formalin fixed and paraffin embedded glioblastoma using real-time pCR.

  PloS one 20120101

• Novel therapies in glioblastoma.

  Neurology research international 20120101

• The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas.

  Neurology research international 20120101

• Current trends in targeted therapies for glioblastoma multiforme.

  Neurology research international 20120101

• Survival outcome and neurotoxicity in patients of high-grade gliomas treated with conformal radiation and temozolamide.

  Journal of cancer research and therapeutics 20120101

• Cell cycle gene networks are associated with melanoma prognosis.

  PloS one 20120101

• Characterizing mutational heterogeneity in a glioblastoma patient with double recurrence.

  PloS one 20120101

• Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials.

  PloS one 20120101

• DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma.

  PloS one 20120101

• Metronomic chemotherapy with the COMBAT regimen in advanced pediatric malignancies: a multicenter experience.

  Oncology 20120101

• Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase.

  PloS one 20120101

• Cellular host responses to gliomas.

  PloS one 20120101

• Effect of angiogenesis inhibitor bevacizumab on survival in patients with cancer: a meta-analysis of the published literature.

  PloS one 20120101

• Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of aberrant cell cycle diseases: an update.

  TheScientificWorldJournal 20120101

• Long-term survival after gamma knife radiosurgery in a case of recurrent glioblastoma multiforme: a case report and review of the literature.

  Case reports in medicine 20120101

• Desmoplastic small round cell tumor: current management and recent findings.

  Sarcoma 20120101

• Methotrexate induced lung injury in a patient with primary CNS lymphoma: a case report.

  Mediterranean journal of hematology and infectious diseases 20120101

• Identification of t(1;19)(q12;p13) and ploidy changes in an ependymosarcoma: a cytogenetic evaluation.

  Clinical neuropathology 20120101

• The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma.

  PloS one 20120101

• Solitary fibrous tumors and so-called hemangiopericytoma.

  Sarcoma 20120101

• Deficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-κB and upregulation of IL-1Ra in melanoma model.

  PloS one 20120101

• Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells.

  PloS one 20120101

• The role of radiation therapy in the management of metastatic melanoma in the brain.

  International journal of surgical oncology 20120101

• A retrospective pooled analysis of response patterns and risk factors in recurrent malignant glioma patients receiving a nitrosourea-based chemotherapy.

  Journal of translational medicine 20120101

• Galectin-1, a gene preferentially expressed at the tumor margin, promotes glioblastoma cell invasion.

  Molecular cancer 20120101

• The social environment and neurogenesis in the adult Mammalian brain.

  Frontiers in human neuroscience 20120101

• Paratesticular desmoplastic small round cell tumour: an unusual tumour with an unusual fusion; cytogenetic and molecular genetic analysis combining RT-PCR and COBRA-FISH.

  Clinical sarcoma research 20120101

• Comprehensive analysis of published phase I/II clinical trials between 1990-2010 in osteosarcoma and Ewing sarcoma confirms limited outcomes and need for translational investment.

  Clinical sarcoma research 20120101

• Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours.

  Clinical sarcoma research 20120101

• Prognostic significance of concomitant radiotherapy in newly diagnosed glioblastoma multiforme: a multivariate analysis of 116 patients.

  Annals of Saudi medicine 20120101

• GABA-A channel subunit expression in human glioma correlates with tumor histology and clinical outcome.

  PloS one 20120101

• Identification of novel human damage response proteins targeted through yeast orthology.

  PloS one 20120101

• Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles.

  International journal of nanomedicine 20120101

• Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival.

  PloS one 20120101

• Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model.

  PloS one 20120101

• Recent medical management of glioblastoma.

  Advances in experimental medicine and biology 20120101

• Primary glioblastoma multiforme of medulla oblongata: Case report and review of literature.

  Asian journal of neurosurgery 20120101

• Template-cut: a pattern-based segmentation paradigm.

  Scientific reports 20120101

• Methylation-mediated molecular dysregulation in clinical oral malignancy.

  Journal of oncology 20120101

• Radiotherapy and erlotinib combined: review of the preclinical and clinical evidence.

  Frontiers in oncology 20120101

• The genomic and proteomic content of cancer cell-derived exosomes.

  Frontiers in oncology 20120101

• Current and emerging pharmacotherapies for primary CNS lymphoma.

  Clinical Medicine Insights. Oncology 20120101

• Preoperative FDG-PET/CT Is an Important Tool in the Management of Patients with Thick (T4) Melanoma.

  Dermatology research and practice 20120101

• Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cells.

  PloS one 20120101

• Therapeutic strategies based on polymeric microparticles.

  Journal of biomedicine & biotechnology 20120101

• Melanoma chemotherapy leads to the selection of ABCB5-expressing cells.

  PloS one 20120101

• Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies.

  Anemia 20120101

• Doxorubicin-mediated radiosensitivity in multicellular spheroids from a lung cancer cell line is enhanced by composite micelle encapsulation.

  International journal of nanomedicine 20120101

• The synergistic effects of DNA-targeted chemotherapeutics and histone deacetylase inhibitors as therapeutic strategies for cancer treatment.

  Current medicinal chemistry 20120101

• Nucleic acids in human glioma treatment: innovative approaches and recent results.

  Journal of signal transduction 20120101

• Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells.

  Journal of biomedicine & biotechnology 20120101

• Metformin: an emerging new therapeutic option for targeting cancer stem cells and metastasis.

  Journal of oncology 20120101

• EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth.

  PloS one 20120101

• Long term experience in high grade glial tumors with temozolomide.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20120101

• Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells.

  PloS one 20120101

• Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Sensitization of glioma cells by X-linked inhibitor of apoptosis protein knockdown.

  Oncology 20120101

• Human monocytes undergo excessive apoptosis following temozolomide activating the ATM/ATR pathway while dendritic cells and macrophages are resistant.

  PloS one 20120101

• Beyond Genetics in Glioma Pathways: The Ever-Increasing Crosstalk between Epigenomic and Genomic Events.

  Journal of signal transduction 20120101

• Strategies to improve the killing of tumors using temozolomide: targeting the DNA repair protein MGMT.

  Current medicinal chemistry 20120101

• Active home-based cancer treatment.

  Journal of multidisciplinary healthcare 20120101

• Immunosignaturing can detect products from molecular markers in brain cancer.

  PloS one 20120101

• Temozolomide combined with radiotherapy in the treatment of recurrent cranial meningioma previously treated with multiple surgical resections and two sessions of radiosurgery: a case report and literature review.

  Tumori 20120101

• Radiosurgery for high-grade glioma.

  Surgical neurology international 20120101

• O6-Methylguanine-methyltransferase (MGMT) promoter methylation status in glioma stem-like cells is correlated to temozolomide sensitivity under differentiation-promoting conditions.

  International journal of molecular sciences 20120101

• Interdisciplinary treatment of glioblastoma: analysis of prognostic factors and treatment results in unselected patients.

  Neoplasma 20120101

• Stem cell based glioblastoma gene therapy.

  Neoplasma 20120101

• Novel nonclassical antifolate, 2-[N-(2´-Hydroxyethyl)amino]methyl-3H-quinazolin-4-one, with a potent antineoplastic activity toward leukemia cells.

  Neoplasma 20120101

• [Temodal--an alkylating cytostatic agent. Effectiveness in patients with malignant gliomas].

  Voprosy onkologii 20120101

• The synergistic therapeutic effect of temozolomide and hyperbaric oxygen on glioma U251 cell lines is accompanied by alterations in vascular endothelial growth factor and multidrug resistance-associated protein-1 levels.

  The Journal of international medical research 20120101

• Combining stereotactic radiosurgery and systemic therapy for brain metastases: a potential role for temozolomide.

  Frontiers in oncology 20120101

• The strategy for enhancing temozolomide against malignant glioma.

  Frontiers in oncology 20120101

• [Treatment for volume upgrading of the low-grade supratentorial glioma after the subtotal neurosurgical resection].

  Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20120101

• Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor.

  Pediatric neurosurgery 20120101

• Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.

  PloS one 20120101

• Management Strategies for Aggressive Cushing's Syndrome: From Macroadenomas to Ectopics.

  Journal of oncology 20120101

• Temozolomide as second or third line treatment of patients with neuroendocrine carcinomas.

  TheScientificWorldJournal 20120101

• Fasting enhances the response of glioma to chemo- and radiotherapy.

  PloS one 20120101

• Survival over 6 years in a patient with brain metastases from melanoma treated with temozolomide.

  BMJ case reports 20120101

• A simplified approach for the molecular classification of glioblastomas.

  PloS one 20120101

• Long-term survival in metastatic malignant melanoma: ipilimumab followed by vemurafenib in a patient with brain metastasis.

  Internal medicine (Tokyo, Japan) 20120101

• Stereotactic intracranial implantation and in vivo bioluminescent imaging of tumor xenografts in a mouse model system of glioblastoma multiforme.

  Journal of visualized experiments : JoVE 20120101

• Management of cytomegalovirus infection in a patient with malignant glioma treated with temozolomide and steroids.

  Internal medicine (Tokyo, Japan) 20120101

• Clinical neuropathology practice guide 06-2012: MGMT testing in elderly glioblastoma patients--yes, but how?

  Clinical neuropathology 20120101

• Hypofractionated Radiotherapy and Stereotactic Boost with Concurrent and Adjuvant Temozolamide for Glioblastoma in Good Performance Status Elderly Patients - Early Results of a Phase II Trial.

  Frontiers in oncology 20120101

• A case of nonfunctioning pituitary carcinoma that responded to temozolomide treatment.

  Case reports in endocrinology 20120101

• Angiogenic potential of the cerebrospinal fluid (CSF) of patients with high-grade gliomas measured with the chick embryo chorioallantoic membrane assay (CAM).

  Biological research 20120101

• Rapid desensitization with temozolomide in patients with delayed maculopapular rash.

  Journal of investigational allergology & clinical immunology 20120101

• Anti-cancer drugs elicit re-expression of UDP-glucuronosyltransferases in melanoma cells.

  PloS one 20120101

• Polifeprosan 20, 3.85% carmustine slow-release wafer in malignant glioma: evidence for role in era of standard adjuvant temozolomide.

  Core evidence 20120101

• Integrins and p53 pathways in glioblastoma resistance to temozolomide.

  Frontiers in oncology 20120101

• Noscapine inhibits tumor growth in TMZ-resistant gliomas.

  Cancer letters 20111222

• Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells.

  Melanoma research 20111201

• Temozolomide (Temodar®) and capecitabine (Xeloda®) treatment of an aggressive corticotroph pituitary tumor.

  Pituitary 20111201

• Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C.

  Investigational new drugs 20111201

• A phase I trial of tipifarnib with radiation therapy, with and without temozolomide, for patients with newly diagnosed glioblastoma.

  International journal of radiation oncology, biology, physics 20111201

• MGMT immunoexpression in adamantinomatous craniopharyngiomas.

  Pituitary 20111201

• Grand rounds at the National Institutes of Health: HDAC inhibitors as radiation modifiers, from bench to clinic.

  Journal of cellular and molecular medicine 20111201

• The status of Tsukuba BNCT trial: BPA-based boron neutron capture therapy combined with X-ray irradiation.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20111201

• Phase II clinical study of boron neutron capture therapy combined with X-ray radiotherapy/temozolomide in patients with newly diagnosed glioblastoma multiforme--study design and current status report.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20111201

• Primary CNS lymphoma other than DLBCL: a descriptive analysis of clinical features and treatment outcomes.

  Annals of hematology 20111201

• Boron neutron capture therapy for newly diagnosed glioblastoma multiforme: an assessment of clinical potential.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20111201

• Primary gliosarcoma--clinical experience from a regional cancer centre in north India.

  British journal of neurosurgery 20111201

• Leptomeningeal dissemination of anaplastic glioma: prolonged survival in two patients treated with temozolomide.

  Journal of neuro-oncology 20111201

• A phase I trial of the farnesyl transferase inhibitor, SCH 66336, with temozolomide for patients with malignant glioma.

  Journal of neuro-oncology 20111201

• O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry.

  Biochimica et biophysica acta 20111201

• Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma.

  Neuro-oncology 20111201

• Communicating hydrocephalus following surgery and adjuvant radiochemotherapy for glioblastoma.

  Journal of neurosurgery 20111201

• Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin.

  Journal of neurosurgery 20111201

• MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis.

  Stem cells (Dayton, Ohio) 20111201

• Reirradiation and concomitant metronomic temozolomide: an efficient combination for local control in medulloblastoma disease?

  Journal of pediatric hematology/oncology 20111201

• Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.

  Nature 20111201

• Towards personalized therapy for patients with glioblastoma.

  Expert review of anticancer therapy 20111201

• Prognostic impact of hemoglobin level and other factors in patients with high-grade gliomas treated with postoperative radiochemotherapy and sequential chemotherapy based on temozolomide: a 10-year experience at a single institution.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20111201

• Early post-treatment pseudo-progression amongst glioblastoma multiforme patients treated with radiotherapy and temozolomide: a retrospective analysis.

  Journal of medical imaging and radiation oncology 20111201

• Pilot study of a pediatric metronomic 4-drug regimen.

  Oncotarget 20111201

• Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma.

  Cell death & disease 20111201

• PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.

  Oncotarget 20111201

• IL-13Rα2-Targeted Therapy Escapees: Biologic and Therapeutic Implications.

  Translational oncology 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Retrospective study of patients with brain metastases from melanoma receiving concurrent whole-brain radiation and temozolomide.

  Anticancer research 20111201

• Expression of EGFRvIII in glioblastoma: prognostic significance revisited.

  Neoplasia (New York, N.Y.) 20111201

• Galectin-1 as an oncotarget in gliomas and melanomas.

  Oncotarget 20111201

• Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies.

  Genes & cancer 20111201

• [Dacarbazine, a chemotherapeutic against metastatic melanoma and a reference drug for new treatment modalities].

  Postepy higieny i medycyny doswiadczalnej (Online) 20111123

• Phase I trial of hypofractionated intensity-modulated radiotherapy with temozolomide chemotherapy for patients with newly diagnosed glioblastoma multiforme.

  International journal of radiation oncology, biology, physics 20111115

• A hypermethylated phenotype is a better predictor of survival than MGMT methylation in anaplastic oligodendroglial brain tumors: a report from EORTC study 26951.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20111115

• Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control.

  Cancer research 20111115

• Veliparib plus temozolomide in metastatic melanoma trends toward increased PFS but results are not statistically significant.

  Oncology (Williston Park, N.Y.) 20111115

• HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A.

  International journal of cancer 20111101

• Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?

  British journal of pharmacology 20111101

• Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor.

  Cancer 20111101

• Cediranib enhances control of wild type EGFR and EGFRvIII-expressing gliomas through potentiating temozolomide, but not through radiosensitization: implications for the clinic.

  Journal of neuro-oncology 20111101

• Assessment of MGMT promoter methylation status in pleomorphic xanthoastrocytoma.

  Journal of neuro-oncology 20111101

• Complete response induced by fotemustine given as single agent in a patient with primary central nervous system non-Hodgkin aggressive lymphoma relapsed after high-dose chemotherapy and autologous stem cell support.

  Leukemia & lymphoma 20111101

• Leptomeningeal melanomatosis: stabilization of disease due to radiation, temozolomide and intrathecal liposomal cytarabine.

  Acta oncologica (Stockholm, Sweden) 20111101

• Using different schedules of Temozolomide to treat low grade gliomas: systematic review of their efficacy and toxicity.

  Journal of neuro-oncology 20111101

• MGMT promoter gene methylation in pediatric glioblastoma: analysis using MS-MLPA.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20111101

• Phase 2 trial of temozolomide and pegylated liposomal doxorubicin in the treatment of patients with glioblastoma multiforme following concurrent radiotherapy and chemotherapy.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20111101

• A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat.

  Acta neuropathologica 20111101

• Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways.

  Oncology reports 20111101

• Membrane-active host defense peptides--challenges and perspectives for the development of novel anticancer drugs.

  Chemistry and physics of lipids 20111101

• Conditional probability of survival in patients with newly diagnosed glioblastoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111101

• Loco-regional treatments in first-diagnosis glioblastoma: literature review on association between Stupp protocol and Gliadel.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20111101

• Rechallenge with temozolomide in recurrent glioma.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20111101

• Lecture: fotemustine in brain tumors.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20111101

• Infections in neuro-oncology.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20111101

• Combination therapy with rituximab and temozolomide for recurrent and refractory primary central nervous system lymphoma.

  Yonsei medical journal 20111101

• Radiochemotherapy with temozolomide for patients with glioblastoma. Prognostic factors and long-term outcome of unselected patients from a single institution.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20111101

• Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.

  Oncotarget 20111101

• The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy.

  Therapeutic advances in medical oncology 20111101

• Cell death forms and HSP70 expression in U87 cells after ionizing radiation and/or chemotherapy.

  Anticancer research 20111101

• Prolonged administration of temozolomide in adult patients with anaplastic glioma.

  Anticancer research 20111101

• [Efficacy and safety of 3-dimensional conformal radiotherapy combined with temozolomide for glioma].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20111101

• De novo aneurysm after treatment of glioblastoma.

  Journal of Korean Neurosurgical Society 20111101

• [Clinical trial updates for malignant brain tumors].

  Rinsho shinkeigaku = Clinical neurology 20111101

• Secondary gliosarcoma after the treatment of primary glioblastoma multiforme.

  North American journal of medical sciences 20111101

• A rare case of an aldosterone secreting metastatic adrenocortical carcinoma and papillary thyroid carcinoma in a 31-year-old male.

  Rare tumors 20111021

• Clinical effect of temozolomide-based chemotherapy in poorly differentiated endocrine carcinoma after progression on first-line chemotherapy.

  Cancer 20111015

• Poly(methyl malate) nanoparticles: formation, degradation, and encapsulation of anticancer drugs.

  Macromolecular bioscience 20111010

• North Central Cancer Treatment Group Phase I trial N057K of everolimus (RAD001) and temozolomide in combination with radiation therapy in patients with newly diagnosed glioblastoma multiforme.

  International journal of radiation oncology, biology, physics 20111001

• Induction of autophagy in temozolomide treated malignant gliomas.

  Neuropathology : official journal of the Japanese Society of Neuropathology 20111001

• Prognostic impact of CD133 mRNA expression in 48 glioblastoma patients treated with concomitant radiochemotherapy: a prospective patient cohort at a single institution.

  Annals of surgical oncology 20111001

• Aggressive pituitary tumours: the role of temozolomide and the assessment of MGMT status.

  European journal of clinical investigation 20111001

• Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer.

  The Journal of investigative dermatology 20111001

• Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma.

  Biomaterials 20111001

• Temozolomide decreases invasion of glioma stem cells by down-regulating TGF-β2.

  Oncology reports 20111001

• Phase II clinical trial evaluating docetaxel, vinorelbine and GM-CSF in stage IV melanoma.

  Cancer chemotherapy and pharmacology 20111001

• RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo.

  Neuro-oncology 20111001

• MGMT immunoexpression in growth hormone-secreting pituitary adenomas and its correlation with Ki-67 labeling index and cytokeratin distribution pattern.

  Endocrine 20111001

• Is surgery at progression a prognostic marker for improved 6-month progression-free survival or overall survival for patients with recurrent glioblastoma?

  Neuro-oncology 20111001

• Advances in tenascin-C biology.

  Cellular and molecular life sciences : CMLS 20111001

• Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma.

  Acta neuropathologica 20111001

• [Glioblastoma in the elderly].

  Revue neurologique 20111001

• Bevacizumab-induced reversible posterior leukoencephalopathy syndrome and successful retreatment in a patient with glioblastoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111001

• Down-regulation of EGFR prolonged cell growth of glioma but did not increase the sensitivity to temozolomide.

  Anticancer research 20111001

• Primary central nervous system lymphoma presenting as Parinaud syndrome.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20111001

• American Society of Clinical Oncology 2011 CNS tumors update.

  Expert review of anticancer therapy 20111001

• Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma.

  Clinics (Sao Paulo, Brazil) 20111001

• Pediatric suprasellar lesions.

  Journal of pediatric neurosciences 20111001

• Management of posterior fossa gliomas in children.

  Journal of pediatric neurosciences 20111001

• Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?

  International journal of environmental research and public health 20111001

• Early-stage progress on glioma vaccines.

  Journal of the National Cancer Institute 20110921

• Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110920

• Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma.

  Neurology 20110920

• Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.

  Blood 20110915

• Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats.

  Medical oncology (Northwood, London, England) 20110901

• Favorable prognosis in patients with high-grade glioma with radiation necrosis: the University of Colorado reoperation series.

  International journal of radiation oncology, biology, physics 20110901

• Genetic variations in VEGF and VEGFR2 and glioblastoma outcome.

  Journal of neuro-oncology 20110901

• Dural venous sinus thrombosis in anaplastic astrocytoma following concurrent temozolomide and focal brain radiotherapy plus bevacizumab.

  Journal of neuro-oncology 20110901

• Combined chemotherapy with temozolomide and fotemustine in recurrent glioblastoma patients.

  Journal of neuro-oncology 20110901

• Characterization of a human tumorsphere glioma orthotopic model using magnetic resonance imaging.

  Journal of neuro-oncology 20110901

• MGMT promoter methylation and immunoexpression in aggressive pituitary adenomas and carcinomas.

  Journal of neuro-oncology 20110901

• Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor Group.

  Annals of oncology : official journal of the European Society for Medical Oncology 20110901

• A multicenter phase I trial of combination therapy with interferon-β and temozolomide for high-grade gliomas (INTEGRA study): the final report.

  Journal of neuro-oncology 20110901

• Leptomeningeal disease in oligodendroglial tumors: a population-based study.

  Journal of neuro-oncology 20110901

• Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas: a prospective single-arm monocentric phase-II study (RNOP-05).

  Journal of neuro-oncology 20110901

• Treatment of pituitary neoplasms with temozolomide: A review.

  Cancer 20110901

• Tissue concentration of systemically administered antineoplastic agents in human brain tumors.

  Journal of neuro-oncology 20110901

• Impact of therapy on quality of life, neurocognitive function and their correlates in glioblastoma multiforme: a review.

  Journal of neuro-oncology 20110901

• Temozolomide may induce therapy-related acute lymphoblastic leukaemia.

  British journal of haematology 20110901

• Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress.

  Angiogenesis 20110901

• Effect of temozolomide on cell viability in gonadotroph adenoma cell lines.

  Oncology reports 20110901

• Treatment of glioblastoma in 'elderly' patients.

  Current treatment options in oncology 20110901

• YB-1 dependent virotherapy in combination with temozolomide as a multimodal therapy approach to eradicate malignant glioma.

  International journal of cancer 20110901

• Multicenter phase II trial of temozolomide in mycosis fungoides/sezary syndrome: correlation with O⁶-methylguanine-DNA methyltransferase and mismatch repair proteins.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110901

• The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival.

  Neurological research 20110901

• Gene expression profiles predicting the response to IFN-β and a combination of temozolomide and IFN-β in malignant gliomas.

  International journal of oncology 20110901

• Antitumor compound testing in glioblastoma organotypic brain cultures.

  Journal of biomolecular screening 20110901

• In regard McDonald et al., to Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma (Int J Radiat Oncol Biol Phys 2011;79:130-136).

  International journal of radiation oncology, biology, physics 20110901

• Prolonged survival when temozolomide is added to accelerated radiotherapy for glioblastoma multiforme.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20110901

• Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions.

  Cell death & disease 20110901

• Second primary glioblastoma multiforme following autologous hematopoietic stem cell transplantation in a patient with acute myelogenous leukemia.

  Cancer research and treatment : official journal of Korean Cancer Association 20110901

• Temozolomide induced liver injury.

  Acta neurologica Belgica 20110901

• [Safety and efficacy of three-dimensional conformal radiotherapy combined with temozolomide in treatment of diffuse brainstem gliomas].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110901

• 3-D conformal radiotherapy with concomitant and adjuvant temozolomide for patients with glioblastoma multiforme and evaluation of prognostic factors.

  Radiology and oncology 20110901

• Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110815

• Rare phenomenon: liver metastases from glioblastoma multiforme.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110810

• Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy.

  Journal of neuro-oncology 20110801

• Longitudinal MRI evidence for decreased survival among periventricular glioblastoma.

  Journal of neuro-oncology 20110801

• Cisplatin and temozolomide combination in the treatment of leptomeningeal carcinomatosis from ethmoid sinus intestinal-type adenocarcinoma.

  Journal of neuro-oncology 20110801

• Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era.

  Journal of neuro-oncology 20110801

• Spinal cord anaplastic oligodendroglioma with 1p deletion: report of a relapsing case treated with temozolomide.

  Journal of neuro-oncology 20110801

• Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas.

  Journal of neuro-oncology 20110801

• The sequential use of carmustine wafers (Gliadel®) and post-operative radiotherapy with concomitant temozolomide followed by adjuvant temozolomide: a clinical review.

  British journal of neurosurgery 20110801

• Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.

  International journal of cancer 20110801

• Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide.

  European journal of obstetrics, gynecology, and reproductive biology 20110801

• Primary brain tumors in the elderly population.

  Current treatment options in neurology 20110801

• High-grade gliomas.

  Current treatment options in neurology 20110801

• Combined use of anticancer drugs and an inhibitor of multiple drug resistance-associated protein-1 increases sensitivity and decreases survival of glioblastoma multiforme cells in vitro.

  Neurochemical research 20110801

• Treatment outcomes for patients with glioblastoma multiforme and a low Karnofsky Performance Scale score on presentation to a tertiary care institution. Clinical article.

  Journal of neurosurgery 20110801

• Seizure control: a secondary benefit of chemotherapeutic temozolomide in brain cancer patients.

  Epilepsy research 20110801

• Immunotherapy for glioblastoma: the devil is in the details.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110801

• Temozolomide in elderly patients with newly diagnosed glioblastoma and poor performance status: an ANOCEF phase II trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110801

• A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo.

  Neuro-oncology 20110801

• Determination of temozolomide in serum and brain tumor with micellar electrokinetic capillary chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110801

• Towards tailored therapy of glioblastoma multiforme.

  Journal of chemotherapy (Florence, Italy) 20110801

• Mouse models to interrogate the implications of the differentiation status in the ontogeny of gliomas.

  Oncotarget 20110801

• The NFκB pathway: a therapeutic target in glioblastoma.

  Oncotarget 20110801

• Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines.

  British journal of cancer 20110726

• Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2.

  The Journal of biological chemistry 20110722

• Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110715

• Response to radiation in renal medullary carcinoma.

  Rare tumors 20110711

• Enhancing adherence to capecitabine chemotherapy by means of multidisciplinary pharmaceutical care.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110701

• Temozolomide during and after radiation therapy for WHO grade III gliomas: preliminary report of a prospective multicenter study.

  Journal of neuro-oncology 20110701

• Efficacy of protracted dose-dense temozolomide in patients with recurrent high-grade glioma.

  Journal of neuro-oncology 20110701

• Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen.

  Journal of neuro-oncology 20110701

• Fractionated stereotactic reirradiation and concurrent temozolomide in patients with recurrent glioblastoma.

  Journal of neuro-oncology 20110701

• Radiotherapy followed by adjuvant temozolomide with or without neoadjuvant ACNU-CDDP chemotherapy in newly diagnosed glioblastomas: a prospective randomized controlled multicenter phase III trial.

  Journal of neuro-oncology 20110701

• PI3Kinase signaling in glioblastoma.

  Journal of neuro-oncology 20110701

• Therapeutic strategies for advanced neuroendocrine carcinomas of jejunum/ileum and pancreatic origin.

  Gut 20110701

• Therapy of aggressive pituitary tumors.

  Expert opinion on pharmacotherapy 20110701

• MGMT promoter methylation and temozolomide response in choroid plexus carcinoma.

  Brain tumor pathology 20110701

• Eckol suppresses maintenance of stemness and malignancies in glioma stem-like cells.

  Toxicology and applied pharmacology 20110701

• Combining temozolomide with other antitumor drugs and target-based agents in the treatment of brain metastases: an unending quest or chasing a chimera?

  Expert opinion on investigational drugs 20110701

• Chemosensitization of glioblastoma cells by the histone deacetylase inhibitor MS275.

  Anti-cancer drugs 20110701

• Telomerase peptide vaccination combined with temozolomide: a clinical trial in stage IV melanoma patients.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110701

• Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: final results of a randomised phase III study (EORTC 18032).

  European journal of cancer (Oxford, England : 1990) 20110701

• Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110701

• Glioblastoma: patterns of recurrence and efficacy of salvage treatments.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20110701

• Melanoma-associated retinopathy: a presenting sign of metastatic disease.

  Journal of the American Academy of Dermatology 20110701

• Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

  Nature medicine 20110701

• Pancreatic endocrine tumors: a report on a patient treated with sorafenib.

  Journal of Korean medical science 20110701

• A case of intracranial malignant fibrous histiocytoma.

  Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110701

• Advances in malignant glioma drug discovery.

  Expert opinion on drug discovery 20110701

• Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.

  Cancer research 20110615

• The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110615

• How fine a slice: treatment of newly diagnosed glioblastoma with an epidermal growth factor receptor variant III peptide vaccine.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110610

• Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas.

  British journal of cancer 20110607

• Implementation of neuro-oncology service reconfiguration in accordance with NICE guidance provides enhanced clinical care for patients with glioblastoma multiforme.

  British journal of cancer 20110607

• Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy.

  British journal of cancer 20110607

• Central nervous system failure in melanoma patients: results of a randomised, multicentre phase 3 study of temozolomide- and dacarbazine- based regimens.

  British journal of cancer 20110607

• Delayed repair of radiation induced clustered DNA damage: friend or foe?

  Mutation research 20110603

• Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951.

  Journal of neuro-oncology 20110601

• Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.

  Journal of neuro-oncology 20110601

• Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells.

  Journal of neuro-oncology 20110601

• Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme.

  Journal of neuro-oncology 20110601

• Correlation of MRI sequences to assess progressive glioblastoma multiforme treated with bevacizumab.

  Journal of neuro-oncology 20110601

• Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy.

  Journal of neuro-oncology 20110601

• Quantitative analysis of O6-methylguanine DNA methyltransferase (MGMT) promoter methylation in patients with low-grade gliomas.

  Journal of neuro-oncology 20110601

• Favorable outcome in the elderly cohort treated by concomitant temozolomide radiochemotherapy in a multicentric phase II safety study of 5-ALA.

  Journal of neuro-oncology 20110601

• Testing new regimens in patients with advanced soft tissue sarcoma: analysis of publications from the last 10 years.

  Annals of oncology : official journal of the European Society for Medical Oncology 20110601

• Advances in MRI assessment of gliomas and response to anti-VEGF therapy.

  Current neurology and neuroscience reports 20110601

• Impact of temozolomide chemotherapy on seizure frequency in patients with low-grade gliomas.

  Journal of neurosurgery 20110601

• Treatment of glioblastoma multiforme with radiotherapy and concomitant and adjuvant temozolomide: translation of randomised controlled trial evidence into routine clinical practice.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20110601

• DNA repair: the culprit for tumor-initiating cell survival?

  Cancer metastasis reviews 20110601

• SMART syndrome: a late reversible complication after radiation therapy for brain tumours.

  Journal of neurology 20110601

• A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma: case report.

  Neurosurgery 20110601

• [Benefit of a prolonged adjuvant treatment with temozolomide for the management of patients with glioblastoma].

  Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20110601

• The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy.

  Oncology reports 20110601

• Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens: DNA damage accumulation contribution.

  Melanoma research 20110601

• Cytoreductive surgery of glioblastoma as the key to successful adjuvant therapies: new arguments in an old discussion.

  Acta neurochirurgica 20110601

• A retrospective survey of patients with malignant gliomas treated in the neuro-oncological care system under the Universal National Health Insurance program in Taiwan.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20110601

• Temozolomide and pituitary adenoma.

  Journal of neurosurgery 20110601

• Management of cutaneous metastases using electrochemotherapy.

  Acta oncologica (Stockholm, Sweden) 20110601

• Overall survival and extent of surgery in adult versus elderly glioblastoma patients: A population based retrospective study.

  Wiener klinische Wochenschrift 20110601

• Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging.

  Journal of magnetic resonance imaging : JMRI 20110601

• Successful desensitization with temozolomide.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20110601

• Glioblastoma multiforme: enhancing survival and quality of life.

  Clinical journal of oncology nursing 20110601

• JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARγ Activation.

  Translational oncology 20110601

• Pathway inhibition: emerging molecular targets for treating glioblastoma.

  Neuro-oncology 20110601

• International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors.

  Neuro-oncology 20110601

• Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors.

  Current medicinal chemistry 20110601

• Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761.

  Neoplasia (New York, N.Y.) 20110601

• [Cutaneous neutrophils infiltrates. Case 4. Pseudo-tumoral cutaneous alternariosis].

  Annales de pathologie 20110601

• Development of glioblastoma cell lines expressing red fluorescence for non-invasive live imaging of intracranial tumors.

  Anticancer research 20110601

• [Problems of chemotherapy for glioma].

  Gan to kagaku ryoho. Cancer & chemotherapy 20110601

• Metabolism and brain cancer.

  Clinics (Sao Paulo, Brazil) 20110601

• Phase I/II trial of cilengitide with cetuximab, cisplatin and 5-fluorouracil in recurrent and/or metastatic squamous cell cancer of the head and neck: findings of the phase I part.

  British journal of cancer 20110524

• Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.

  Proceedings of the National Academy of Sciences of the United States of America 20110524

• Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110515

• Comparison of corticotropin-releasing factor, dexamethasone, and temozolomide: treatment efficacy and toxicity in U87 and C6 intracranial gliomas.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110515

• KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells.

  Biochemical pharmacology 20110515

• Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system.

  Journal of the National Cancer Institute 20110504

• Palonosetron for the prevention of chemotherapy-induced nausea and vomiting in glioblastoma patients treated with temozolomide: a phase II study.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110501

• Prognostic value of early [18F]fluoroethyltyrosine positron emission tomography after radiochemotherapy in glioblastoma multiforme.

  International journal of radiation oncology, biology, physics 20110501

• A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma.

  Journal of neuro-oncology 20110501

• Hepatic encephalopathy after treatment with temozolomide.

  Journal of neuro-oncology 20110501

• Feasibility study of 21-day-on/7-day-off temozolomide in children with brain tumors.

  Journal of neuro-oncology 20110501

• Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma.

  Journal of neuro-oncology 20110501

• Treatment of follicular non-Hodgkin's lymphoma with or without rituximab: cost-effectiveness and value of information based on a 5-year follow-up.

  Annals of oncology : official journal of the European Society for Medical Oncology 20110501

• Immature and absolute platelet count changes and thrombocytopenia in malignant glioma.

  European journal of clinical investigation 20110501

• Dopamine agonist-resistant prolactinomas.

  Journal of neurosurgery 20110501

• The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma.

  European journal of cancer (Oxford, England : 1990) 20110501

• A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts.

  Acta neuropathologica 20110501

• Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells.

  Neuro-oncology 20110501

• N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.

  Neuro-oncology 20110501

• Temozolomide-induced modification of the CXC chemokine network in experimental gliomas.

  International journal of oncology 20110501

• Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells.

  International journal of radiation biology 20110501

• An algorithm for chemotherapy treatment of recurrent glioma patients after temozolomide failure in the general oncology setting.

  Cancer chemotherapy and pharmacology 20110501

• Prognostic impact of postoperative, pre-irradiation (18)F-fluoroethyl-l-tyrosine uptake in glioblastoma patients treated with radiochemotherapy.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20110501

• Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation chemotherapy.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20110501

• Considering temozolomide as a novel potential treatment for esophageal cancer.

  Cancer 20110501

• PARP inhibitors stumble in breast cancer.

  Nature biotechnology 20110501

• NRAS-mutant melanoma: response to chemotherapy.

  Archives of dermatology 20110501

• The effect of PTEN on proliferation and drug-, and radiosensitivity in malignant glioma cells.

  Anticancer research 20110501

• [News on melanoma from the 2010 Dermatology Days in Paris].

  Annales de dermatologie et de venereologie 20110501

• Early toxicity predicts long-term survival in high-grade glioma.

  British journal of cancer 20110426

• Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter: A multicenter study.

  Cancer 20110415

• Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110415

• A pilot study of hypofractionated radiation therapy with temozolomide for adults with glioblastoma multiforme.

  Journal of neuro-oncology 20110401

• Determination of the methylation status of MGMT in different regions within glioblastoma multiforme.

  Journal of neuro-oncology 20110401

• Combination of 6-thioguanine, capecitabine, and celecoxib with temozolomide or lomustine for recurrent high-grade glioma.

  Journal of neuro-oncology 20110401

• Kitten-transmitted Bordetella bronchiseptica infection in a patient receiving temozolomide for glioblastoma.

  Journal of neuro-oncology 20110401

• Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide.

  Journal of neuro-oncology 20110401

• Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells.

  Journal of cellular physiology 20110401

• Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide.

  Journal of neurology, neurosurgery, and psychiatry 20110401

• Temozolomide-based dry powder formulations for lung tumor-related inhalation treatment.

  Pharmaceutical research 20110401

• The combi-targeting concept: mechanism of action of the pleiotropic combi-molecule RB24 and discovery of a novel cell signaling-based combination principle.

  Cellular signalling 20110401

• Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model.

  Biomaterials 20110401

• Response to temozolomide in patients with metastatic colorectal cancer with loss of MGMT expression: a new approach in the era of personalized medicine?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110401

• Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide.

  Neuro-oncology 20110401

• O6-methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma.

  Brain tumor pathology 20110401

• Immune modulation effects of concomitant temozolomide and radiation therapy on peripheral blood mononuclear cells in patients with glioblastoma multiforme.

  Neuro-oncology 20110401

• Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group.

  Neuro-oncology 20110401

• The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110401

• AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme.

  Advances in therapy 20110401

• Temozolomide modifies caveolin-1 expression in experimental malignant gliomas in vitro and in vivo.

  Translational oncology 20110401

• Factors influencing the response to high dose methotrexate-based vincristine and procarbazine combination chemotherapy for primary central nervous system lymphoma.

  Journal of Korean medical science 20110401

• Glioblastoma: changing expectations?

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110401

• Response to nimotuzumab in a child with a progressive diffuse intrinsic pontine glioma.

  Pediatrics international : official journal of the Japan Pediatric Society 20110401

• Atypical teratoid/rhabdoid tumors in adults: a case report and treatment-focused review.

  Journal of clinical medicine research 20110401

• Spinal intradural extraosseous Ewing's sarcoma.

  Rare tumors 20110330

• Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy.

  Neurology 20110329

• Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models.

  Cancer letters 20110328

• A novel approach to overcome temozolomide resistance in glioma and melanoma: Inactivation of MGMT by gene therapy.

  Biochemical and biophysical research communications 20110318

• Chemotherapy wafers for high grade glioma.

  The Cochrane database of systematic reviews 20110316

• Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair.

  Cancer research 20110315

• Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs.

  Cancer chemotherapy and pharmacology 20110301

• Factors involved in maintaining prolonged functional independence following supratentorial glioblastoma resection. Clinical article.

  Journal of neurosurgery 20110301

• Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma.

  Journal of neuro-oncology 20110301

• Pseudoprogression in patients with malignant gliomas treated with concurrent temozolomide and radiotherapy: potential role of p53.

  Journal of neuro-oncology 20110301

• Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. Clinical article.

  Journal of neurosurgery 20110301

• Temozolomide for corticotroph pituitary adenomas refractory to standard therapy.

  Pituitary 20110301

• High-dose carboplatin-irinotecan-temozolomide: treatment option for neuroblastoma resistant to topotecan.

  Pediatric blood & cancer 20110301

• Advances in translational research in neuro-oncology.

  Archives of neurology 20110301

• Bevacizumab and irinotecan in the treatment of children with recurrent/refractory medulloblastoma.

  Pediatric blood & cancer 20110301

• Advances in translational research provide a rationale for clinical re-evaluation of high-dose radiotherapy for glioblastoma.

  Medical hypotheses 20110301

• Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma.

  Neuro-oncology 20110301

• Use of Bevacizumab for neurological complications during initial treatment of malignant gliomas.

  Neurologia (Barcelona, Spain) 20110301

• Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome.

  Epigenetics 20110301

• Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticles to glioma via intravenous administration.

  Biomaterials 20110301

• Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study.

  Acta neurochirurgica 20110301

• BTECH: a platform to integrate genomic, transcriptomic and epigenomic alterations in brain tumors.

  Neuroinformatics 20110301

• Intramedullary PNET of the spine: long-term survival after combined modality therapy and subsequent relapse.

  Journal of pediatric hematology/oncology 20110301

• MGMT is a molecular determinant for potency of the DNA-EGFR-combi-molecule ZRS1.

  Molecular cancer research : MCR 20110301

• EGFR gene overexpression retained in an invasive xenograft model by solid orthotopic transplantation of human glioblastoma multiforme into nude mice.

  Cancer investigation 20110301

• A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.

  British journal of cancer 20110301

• Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group.

  Neuro-oncology 20110301

• Controversies in the adjuvant therapy of high-grade gliomas.

  The oncologist 20110301

• Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation.

  Journal of molecular medicine (Berlin, Germany) 20110301

• Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.

  Oncotarget 20110301

• Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies.

  Future oncology (London, England) 20110301

• [MGMT analysis in gliomas].

  Bulletin du cancer 20110301

• Safety and feasibility of the adjunct of local chemotherapy with biodegradable carmustine (BCNU) wafers to the standard multimodal approach to high grade gliomas at first diagnosis.

  Journal of neurosurgical sciences 20110301

• Vascular co-option in lung cancer metastatic to the eye after treatment with bevacizumab.

  Journal of ophthalmic inflammation and infection 20110301

• [A case of primary diffuse leptomeningeal gliomatosis, clinically indistinguishable from metastatic meningeal carcinomatosis].

  Rinsho shinkeigaku = Clinical neurology 20110301

• Response to temozolomide in supratentorial multifocal recurrence of malignant ependymoma.

  Anticancer research 20110301

• [Nimotuzumab in combination with chemotherapy for patients with malignant gliomas].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110301

• [Pituitary carcinoma].

  Nihon rinsho. Japanese journal of clinical medicine 20110301

• Monitoring radiographic brain tumor progression.

  Toxins 20110301

• STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: a potential for targeted therapy?

  International journal of cancer 20110215

• Gene expression profiling of gliomas: merging genomic and histopathological classification for personalised therapy.

  British journal of cancer 20110215

• Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines.

  British journal of cancer 20110215

• Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells.

  Bioscience reports 20110201

• Temozolomide-induced inhibition of pituitary adenoma cells.

  Journal of neurosurgery 20110201

• Up-front temozolomide in elderly patients with anaplastic oligodendroglioma and oligoastrocytoma.

  Journal of neuro-oncology 20110201

• Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors.

  Journal of neuro-oncology 20110201

• MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.

  Journal of neuro-oncology 20110201

• Treatment of pituitary neoplasms with temozolomide: a review.

  Cancer 20110201

• siRNA knockdown of ribonucleotide reductase inhibits melanoma cell line proliferation alone or synergistically with temozolomide.

  The Journal of investigative dermatology 20110201

• Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells.

  International journal of radiation biology 20110201

• Usefulness of MS-MLPA for detection of MGMT promoter methylation in the evaluation of pseudoprogression in glioblastoma patients.

  Neuro-oncology 20110201

• Patient profiling for treatment toxicity: potential use of clinical and genomic factors.

  Current oncology reports 20110201

• In vivo imaging of early stage apoptosis by measuring real-time caspase-3/7 activation.

  Apoptosis : an international journal on programmed cell death 20110201

• Targeting BRAF for patients with melanoma.

  British journal of cancer 20110201

• The correlation between promoter methylation status and the expression level of O6-methylguanine-DNA methyltransferase in recurrent glioma.

  Japanese journal of clinical oncology 20110201

• First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.

  Neuro-oncology 20110201

• Case of atypical teratoid/rhabdoid tumor in an adult, with long survival.

  Brain tumor pathology 20110201

• APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo.

  Neuro-oncology 20110201

• The use and effectiveness of temozolomide in children with central nervous system tumours: a survey from the Canadian Paediatric Brain Tumour Consortium.

  Current oncology (Toronto, Ont.) 20110201

• Bevacizumab as a treatment option for radiation-induced cerebral necrosis.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20110201

• Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts.

  Cell death & disease 20110201

• The emerging role of the thrombin receptor (PAR-1) in melanoma metastasis--a possible therapeutic target.

  Oncotarget 20110201

• Patterns of failure for glioblastoma multiforme following concurrent radiation and temozolomide.

  Journal of medical imaging and radiation oncology 20110201

• Phase I trial of a personalized peptide vaccine for patients positive for human leukocyte antigen--A24 with recurrent or progressive glioblastoma multiforme.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110120

• First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.

  Cancer 20110115

• Phase II study of irinotecan and temozolomide in children with relapsed or refractory neuroblastoma: a Children's Oncology Group study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110110

• Taming glioblastoma by targeting angiogenesis: 3 years later.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110110

• Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110110

• [Comparison of MGMT and ERCC₂ expression in temozolomide for the treatment of malignant glioma drug resistance and their genetic relationship].

  Zhonghua yi xue za zhi 20110104

• Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma.

  International journal of radiation oncology, biology, physics 20110101

• Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma.

  Journal of neuro-oncology 20110101

• Temozolomide for malignant primary spinal cord glioma: an experience of six cases and a literature review.

  Journal of neuro-oncology 20110101

• Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study.

  Journal of neuro-oncology 20110101

• Trabectedin in the treatment of metastatic soft tissue sarcoma: cost-effectiveness, cost-utility and value of information.

  Annals of oncology : official journal of the European Society for Medical Oncology 20110101

• Multiple primary cranio-spinal tumours in a 13-year-old female with neurofibromatosis type 2 management strategy.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20110101

• Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients.

  Annals of surgical oncology 20110101

• A clinicopathological and molecular analysis of glioblastoma multiforme with long-term survival.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20110101

• High-dose cyclophosphamide-irinotecan-vincristine for primary refractory neuroblastoma.

  European journal of cancer (Oxford, England : 1990) 20110101

• Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients.

  Anti-cancer drugs 20110101

• Growth Inhibition and Induction of Apoptosis in SHG-44 Glioma Cells by Chinese Medicine Formula 'Pingliu Keli'.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy.

  Molecular medicine (Cambridge, Mass.) 20110101

• High-field iMRI in glioblastoma surgery: improvement of resection radicality and survival for the patient?

  Acta neurochirurgica. Supplement 20110101

• Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion.

  Neuro-oncology 20110101

• Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study.

  Neuro-oncology 20110101

• Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma.

  Neuro-oncology 20110101

• Down-regulation of O6-methylguanine-DNA methyl transferase enhances the effect of temozolomide in melanoma cells.

  Medical hypotheses 20110101

• Targeted Therapy of Ewing's Sarcoma.

  Sarcoma 20110101

• MGMT promoter methylation in pediatric high-grade gliomas.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20110101

• Radiographic patterns of relapse in glioblastoma.

  Journal of neuro-oncology 20110101

• Evaluation of the anticancer activities of two fungal polycyclic ethanones, alternethanoxins A and B, and two of their derivatives.

  International journal of oncology 20110101

• Placenta growth factor induces melanoma resistance to temozolomide through a mechanism that involves the activation of the transcription factor NF-κB.

  International journal of oncology 20110101

• Synergistic therapeutic effects of cytokine-induced killer cells and temozolomide against glioblastoma.

  Oncology reports 20110101

• Regional treatment strategies for in-transit melanoma metastasis.

  Surgical oncology clinics of North America 20110101

• Current therapeutic approaches in metastatic and recurrent ewing sarcoma.

  Sarcoma 20110101

• Transferrin-appended PEGylated nanoparticles for temozolomide delivery to brain: in vitro characterisation.

  Journal of microencapsulation 20110101

• [Drug therapy of patients with recurrent glioblastoma: is there any evidence?].

  Wiener medizinische Wochenschrift (1946) 20110101

• Targeting angiogenesis in childhood sarcomas.

  Sarcoma 20110101

• Neurosurgical treatment of breast cancer metastases to the neurocranium.

  Pathology research international 20110101

• Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors.

  Journal of oncology 20110101

• Systematic review of medical treatment in melanoma: current status and future prospects.

  The oncologist 20110101

• Antiangiogenic agents in the treatment of recurrent or newly diagnosed glioblastoma: analysis of single-agent and combined modality approaches.

  Radiation oncology (London, England) 20110101

• A combined preclinical therapy of cannabinoids and temozolomide against glioma.

  Molecular cancer therapeutics 20110101

• Anti-retinal pigment epithelium antibodies in acute exudative polymorphous vitelliform maculopathy: a new hypothesis about disease pathogenesis.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20110101

• INI1 immunohistochemical expression in glioblastoma: correlation with MGMT gene promoter methylation status and patient survival.

  Pathology 20110101

• Exploiting the complexity of the genome and transcriptome using pharmacogenomics towards personalized medicine.

  Genome biology 20110101

• Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response.

  Radiation oncology (London, England) 20110101

• Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.

  PloS one 20110101

• Receptor tyrosine kinases as therapeutic targets in rhabdomyosarcoma.

  Sarcoma 20110101

• Blood-brain barrier integrity and breast cancer metastasis to the brain.

  Pathology research international 20110101

• TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro.

  PloS one 20110101

• Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma.

  PloS one 20110101

• A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples.

  BMC medical genomics 20110101

• O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction.

  BMC cancer 20110101

• Pathogenesis, diagnosis and management of primary melanoma of the colon.

  World journal of surgical oncology 20110101

• Treatment of Parkinson's disease: nanostructured sol-gel silica-dopamine reservoirs for controlled drug release in the central nervous system.

  International journal of nanomedicine 20110101

• Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors.

  PloS one 20110101

• A novel method for volumetric MRI response assessment of enhancing brain tumors.

  PloS one 20110101

• DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer.

  PloS one 20110101

• [Pseudoprogression or pseudoresponse: a challenge for the diagnostic imaging in Glioblastoma multiforme].

  Wiener medizinische Wochenschrift (1946) 20110101

• Sodium ion channel mutations in glioblastoma patients correlate with shorter survival.

  Molecular cancer 20110101

• GRP78/BiP modulation of GRP78/BiP in altering sensitivity to chemotherapy.

  Methods in enzymology 20110101

• Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy.

  PloS one 20110101

• Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury.

  PloS one 20110101

• Unfolded protein response in cancer: the physician's perspective.

  Journal of hematology & oncology 20110101

• O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation.

  PloS one 20110101

• Sensitivity to cisplatin in primary cell lines derived from human glioma correlates with levels of EGR-1 expression.

  Cancer cell international 20110101

• Validation of the new Graded Prognostic Assessment scale for brain metastases: a multicenter prospective study.

  Radiation oncology (London, England) 20110101

• EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis.

  Molecular cancer 20110101

• A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion.

  PloS one 20110101

• Future perspectives in melanoma research. Meeting report from the 'Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010'.

  Journal of translational medicine 20110101

• Radiation-induced astrocytoma with rapid malignant transformation: case report.

  Neurologia medico-chirurgica 20110101

• Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles.

  International journal of nanomedicine 20110101

• Regulation of glioblastoma progression by cord blood stem cells is mediated by downregulation of cyclin D1.

  PloS one 20110101

• Quantitative model for efficient temporal targeting of tumor cells and neovasculature.

  Computational and mathematical methods in medicine 20110101

• Computational modeling of tumor response to vascular-targeting therapies--part I: validation.

  Computational and mathematical methods in medicine 20110101

• Combined treatment of uveal melanoma liver metastases.

  European journal of medical research 20110101

• Differential analysis of glioblastoma multiforme proteome by a 2D-DIGE approach.

  Proteome science 20110101

• An effective personalized approach to a rare tumor: prolonged survival in metastatic pancreatic acinar cell carcinoma based on genetic analysis and cell line development.

  Journal of Cancer 20110101

• Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C™), doxorubicin (Caelyx®) or vincristine.

  BMC cancer 20110101

• Collagen triple helix repeat containing 1 promotes melanoma cell adhesion and survival.

  Journal of cutaneous medicine and surgery 20110101

• A melanoma molecular disease model.

  PloS one 20110101

• Influence of caloric restriction on constitutive expression of NF-κB in an experimental mouse astrocytoma.

  PloS one 20110101

• O6 -methylguanine DNA methyltransferase gene promoter methylation in high-grade gliomas: a review of current status.

  Neurology India 20110101

• Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme.

  PloS one 20110101

• A ten-microRNA expression signature predicts survival in glioblastoma.

  PloS one 20110101

• Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect.

  Perspectives in medicinal chemistry 20110101

• Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma.

  Journal of neuroinflammation 20110101

• Tumor suppressor gene-based nanotherapy: from test tube to the clinic.

  Journal of drug delivery 20110101

• Targeted morphoproteomic profiling of Ewing's sarcoma treated with insulin-like growth factor 1 receptor (IGF1R) inhibitors: response/resistance signatures.

  PloS one 20110101

• The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo.

  Radiation oncology (London, England) 20110101

• Achievement of three year remission with bevacizumab and irinotecan in recurrent glioblastoma multiforme: a case report.

  Clinical Medicine Insights. Oncology 20110101

• Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer.

  Molecular cancer 20110101

• Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.

  Journal of hematology & oncology 20110101

• Camptothecin-based regimens for treatment of ewing sarcoma: past studies and future directions.

  Sarcoma 20110101

• The validation of the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30) in pre-operative patients with brain tumor in China.

  BMC medical research methodology 20110101

• Pathological changes after autologous formalin-fixed tumor vaccine therapy combined with temozolomide for glioblastoma - three case reports - .

  Neurologia medico-chirurgica 20110101

• Delayed but Complete Response following Oral Temozolomide Treatment in Melanoma Leptomeningeal Carcinomatosis.

  Case reports in oncology 20110101

• Medication safety of five oral chemotherapies: a proactive risk assessment.

  Journal of oncology practice 20110101

• Long-term survival with primary glioblastoma multiforme: a clinical study in bulgarian patients.

  Case reports in oncology 20110101

• Autologous peripheral blood mononuclear cell recognition of autologous proliferating tumor cells in the context of a patient-specific vaccine trial.

  Journal of biomedicine & biotechnology 20110101

• Integrin targeted therapeutics.

  Theranostics 20110101

• Metastatic malignant melanoma presenting as an appendiceal mucocele.

  Journal of oncology 20110101

• The beneficial effects of physical activity on impaired adult neurogenesis and cognitive performance.

  Frontiers in neuroscience 20110101

• Preclinical testing of erlotinib in a transgenic alveolar rhabdomyosarcoma mouse model.

  Sarcoma 20110101

• High-dose chemotherapy with autologous hematopoietic stem-cell rescue for pediatric brain tumor patients: a single institution experience from UCLA.

  Journal of transplantation 20110101

• Review of the 25th annual scientific meeting of the International Society for Biological Therapy of Cancer.

  Journal of translational medicine 20110101

• Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells.

  BMC cancer 20110101

• Multiple courses of stereotactic re-irradiation in recurrent oligodendroglioma: a case report.

  Journal of medical case reports 20110101

• FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.

  PloS one 20110101

• Oncogene addiction in gliomas: implications for molecular targeted therapy.

  Journal of experimental & clinical cancer research : CR 20110101

• Another cause of pancytopenia in a patient receiving temozolomide.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20110101

• Concordance of self-reported and medical chart information on cancer diagnosis and treatment.

  BMC medical research methodology 20110101

• Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells.

  Molecular cancer 20110101

• Extracranial propagation of glioblastoma with extension to pterygomaxillar fossa.

  World journal of surgical oncology 20110101

• STAT6 expression in glioblastoma promotes invasive growth.

  BMC cancer 20110101

• Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells.

  Molecular cancer 20110101

• Kinetic studies of the effects of Temodal and quercetin on astrocytoma cells.

  Pharmacological reports : PR 20110101

• The Clinical Value of PET with Amino Acid Tracers for Gliomas WHO Grade II.

  International journal of molecular imaging 20110101

• Bevacizumab for the treatment of recurrent glioblastoma.

  Clinical Medicine Insights. Oncology 20110101

• Novel diagnostic and therapeutic approaches to malignant glioma.

  Swiss medical weekly 20110101

• Interpreting clinical assays for histone deacetylase inhibitors.

  Cancer management and research 20110101

• MicroRNAs Regulate Key Effector Pathways of Senescence.

  Journal of aging research 20110101

• Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation.

  PloS one 20110101

• A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells.

  Molecular cancer 20110101

• [Multimodal treatment of glioblastoma multiforme: results of 86 consecutive patients diagnosed in period 2003-2009].

  Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20110101

• Transport processes of radiopharmaceuticals and -modulators.

  Radiation oncology (London, England) 20110101

• Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival.

  BMC medical genomics 20110101

• Epigenetic changes in cancer.

  F1000 biology reports 20110101

• Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma.

  Pathology research international 20110101

• Delayed cell death associated with mitotic catastrophe in γ-irradiated stem-like glioma cells.

  Radiation oncology (London, England) 20110101

• Evolving diagnostic and treatment strategies for pancreatic neuroendocrine tumors.

  Journal of hematology & oncology 20110101

• Application of hyperthermia induced by superparamagnetic iron oxide nanoparticles in glioma treatment.

  International journal of nanomedicine 20110101

• Cancer stem cells and malignant gliomas. From pathophysiology to targeted molecular therapy.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• Concomitant temozolomide and radiotherapy versus radiotherapy alone for treatment of newly diagnosed glioblastoma multiforme.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• Serum granulocyte colony-stimulating factor levels in gliomas.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells.

  PloS one 20110101

• Identification of novel SNPs in glioblastoma using targeted resequencing.

  PloS one 20110101

• Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis.

  German medical science : GMS e-journal 20110101

• MMP-2 siRNA inhibits radiation-enhanced invasiveness in glioma cells.

  PloS one 20110101

• Statistical quantification of methylation levels by next-generation sequencing.

  PloS one 20110101

• Treatment of HIV-related primary central nervous system lymphoma with AZT high dose, HAART, interleukin-2 and foscarnet in three patients.

  European journal of medical research 20110101

• Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair.

  Oncology 20110101

• Aggressive silent corticotroph adenoma progressing to pituitary carcinoma: the role of temozolomide therapy.

  Hormones (Athens, Greece) 20110101

• The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner.

  PloS one 20110101

• Brief report: phase II multicenter study of temozolomide in patients with cisplatin-resistant germ cell tumors.

  Oncology 20110101

• Antiproliferative effects of Tubi-bee propolis in glioblastoma cell lines.

  Genetics and molecular biology 20110101

• Induction of immune mediators in glioma and prostate cancer cells by non-lethal photodynamic therapy.

  PloS one 20110101

• Enhancement of the click chemistry for the inverse Diels Alder technology by functionalization of amide-based monomers.

  International journal of medical sciences 20110101

• The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.

  Molecular cancer 20110101

• Absence of common somatic alterations in genes on 1p and 19q in oligodendrogliomas.

  PloS one 20110101

• Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.

  Journal of biomedicine & biotechnology 20110101

• Metformin plus temozolomide-based chemotherapy as adjuvant treatment for WHO grade III and IV malignant gliomas.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects.

  BMC cancer 20110101

• Primary meningeal rhabdomyosarcoma.

  Sarcoma 20110101

• Uveal melanoma.

  Journal of skin cancer 20110101

• Teratoma with malignant transformation: a case report with pathological, cytogenetic, and immunohistochemistry analysis.

  Sarcoma 20110101

• Application of Benchtop-magnetic resonance imaging in a nude mouse tumor model.

  Journal of experimental & clinical cancer research : CR 20110101

• Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.

  BMC cancer 20110101

• Ifosfamide, carboplatin and etoposide in recurrent malignant glioma.

  Oncology 20110101

• Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft.

  Journal of translational medicine 20110101

• [Significant regression of glioblastoma with low level of Mgmt gene expression following radiotherapy].

  Voprosy onkologii 20110101

• Drug therapy for hereditary cancers.

  Hereditary cancer in clinical practice 20110101

• Extracranial skeletal metastasis in anaplastic oligodendroglioma: case report and review of the literature.

  The Journal of international medical research 20110101

• Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells.

  PloS one 20110101

• The role of integrins in glioma biology and anti-glioma therapies.

  Current pharmaceutical design 20110101

• Why is there a lack of consensus on molecular subgroups of glioblastoma? Understanding the nature of biological and statistical variability in glioblastoma expression data.

  PloS one 20110101

• Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.

  PloS one 20110101

• The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma.

  PloS one 20110101

• Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?

  ASN neuro 20110101

• Efficacy of gamma knife radiosurgery for small-volume recurrent malignant gliomas after initial radical resection.

  World neurosurgery 20110101

• Adjuvant temozolomide chemotherapy for treatment of papillary tumor of the pineal region.

  World neurosurgery 20110101

• Method for novel anti-cancer drug development using tumor explants of surgical specimens.

  Journal of visualized experiments : JoVE 20110101

• Patient specification quality assurance for glioblastoma multiforme brain tumors treated with intensity modulated radiation therapy.

  International journal of medical sciences 20110101

• β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance.

  PloS one 20110101

• Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.

  Chinese medicine 20110101

• Management options in triple-negative breast cancer.

  Breast cancer : basic and clinical research 20110101

• Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres.

  Journal of oncology 20110101

• Molecular characteristics of pediatric non-ependymal, non‑pilocytic gliomas associated with resistance to temozolomide.

  Molecular medicine reports 20110101

• Molecular bases of cutaneous and uveal melanomas.

  Pathology research international 20110101

• Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer?

  Breast cancer research : BCR 20110101

• BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells.

  PloS one 20110101

• Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.

  BMC cancer 20110101

• Formulation and evaluation of solid lipid nanoparticles of ramipril.

  Journal of young pharmacists : JYP 20110101

• The combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53.

  PloS one 20110101

• Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review.

  Frontiers in pharmacology 20110101

• Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?

  Radiation oncology (London, England) 20110101

• Cetuximab augments cytotoxicity with poly (adp-ribose) polymerase inhibition in head and neck cancer.

  PloS one 20110101

• Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma.

  PloS one 20110101

• CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway.

  PloS one 20110101

• Electrochemotherapy with cisplatin enhances local control after surgical ablation of fibrosarcoma in cats: an approach to improve the therapeutic index of highly toxic chemotherapy drugs.

  Journal of translational medicine 20110101

• A spinal cord astrocytoma and its concurrent osteoblastic metastases at the time of the initial diagnosis: a case report and literature review.

  Korean journal of radiology 20110101

• Acquisition of chemoresistance in gliomas is associated with increased mitochondrial coupling and decreased ROS production.

  PloS one 20110101

• Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms.

  PloS one 20110101

• Evaluation of early imaging response criteria in glioblastoma multiforme.

  Radiation oncology (London, England) 20110101

• Future of radiation therapy for malignant melanoma in an era of newer, more effective biological agents.

  OncoTargets and therapy 20110101

• Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12.

  PloS one 20110101

• Diagnostic utility of IDH1- and p53-mutation analysis in secondary gliosarcoma.

  Clinical neuropathology 20110101

• Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells.

  PloS one 20110101

• MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes.

  Lipids in health and disease 20110101

• Platinum resistance in breast and ovarian cancer cell lines.

  Journal of experimental & clinical cancer research : CR 20110101

• A simple guide screw method for intracranial xenograft studies in mice.

  Journal of visualized experiments : JoVE 20110101

• Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells.

  Radiation oncology (London, England) 20110101

• Fibronectin matrix assembly suppresses dispersal of glioblastoma cells.

  PloS one 20110101

• The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.

  PloS one 20110101

• The challenges of managing glioblastoma multiforme in developing countries: a trade-off between cost and quality of care.

  Hematology/oncology and stem cell therapy 20110101

• Outcomes of patients with metastatic melanoma treated with molecularly targeted agents in phase I clinical trials.

  Oncology 20110101

• Chemoresistance of glioblastoma cancer stem cells--much more complex than expected.

  Molecular cancer 20110101

• Preoperative Visual Loss is the Main Cause of Irreversible Poor Vision in Children with a Brain Tumor.

  Frontiers in neurology 20110101

• Radiogenomic mapping of edema/cellular invasion MRI-phenotypes in glioblastoma multiforme.

  PloS one 20110101

• Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor.

  Molecular cancer 20110101

• Temozolomide-related infections: review of the literature.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• Treatment of liver metastases in patients with neuroendocrine tumors: a comprehensive review.

  International journal of hepatology 20110101

• Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study.

  PloS one 20110101

• Toxicity after radiochemotherapy for glioblastoma using temozolomide--a retrospective evaluation.

  Radiation oncology (London, England) 20110101

• Response to intrathecal infusions of Depocyt® in secondary diffuse leptomeningeal gliomatosis. A case report.

  In vivo (Athens, Greece) 20110101

• Long survival of primary diffuse leptomeningeal gliomatosis following radiotherapy and temozolomide: case report and literature review.

  European journal of medical research 20110101

• Reactivation of hepatitis B virus after glioblastoma treatment with temozolomide--case report.

  Neurologia medico-chirurgica 20110101

• Evolving evidence implicates cytomegalovirus as a promoter of malignant glioma pathogenesis.

  Herpesviridae 20110101

• Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells.

  BMC cancer 20110101

• Invasion is not an independent prognostic factor in high-grade glioma.

  Journal of cancer research and therapeutics 20110101

• The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival.

  PloS one 20110101

• Sensitization of glioma cells to tamoxifen-induced apoptosis by Pl3-kinase inhibitor through the GSK-3β/β-catenin signaling pathway.

  PloS one 20110101

• Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice.

  Bone marrow research 20110101

• Ocular melanoma: Keep your eyes open for late brain metastases.

  Surgical neurology international 20110101

• Mitochondrial peroxiredoxin III is a potential target for cancer therapy.

  International journal of molecular sciences 20110101

• Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.

  PloS one 20110101

• Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr.

  Radiation oncology (London, England) 20110101

• Anti-CTLA4 monoclonal antibodies: the past and the future in clinical application.

  Journal of translational medicine 20110101

• Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.

  Clinical Medicine Insights. Oncology 20110101

• Clinical use of the low-molecular-weight heparins in cancer patients: focus on the improved patient outcomes.

  Thrombosis 20110101

• Surgical brain metastases: management and outcome related to prognostic indexes: a critical review of a ten-year series.

  ISRN surgery 20110101

• Cerebral melanoma metastases: a critical review on diagnostic methods and therapeutic options.

  ISRN surgery 20110101

• [Issues around diffuse glioma].

  Nederlands tijdschrift voor geneeskunde 20110101

• Innovative Therapies against Human Glioblastoma Multiforme.

  ISRN oncology 20110101

• Albendazole sensitizes cancer cells to ionizing radiation.

  Radiation oncology (London, England) 20110101

• Nanostructured Pt(NH(3))(4)Cl(2)/SiO(2) for nanomedicine: catalytic degradation of DNA in cancer cells.

  Nano reviews 20110101

• Uptake and intracellular traffic of siRNA dendriplexes in glioblastoma cells and macrophages.

  International journal of nanomedicine 20110101

• Diffusion MR Imaging of the Brain in Patients with Cancer.

  International journal of molecular imaging 20110101

• The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications.

  TheScientificWorldJournal 20110101

• The therapeutic potential of inhibitors of the signal transducer and activator of transcription 3 for central nervous system malignancies.

  Surgical neurology international 20110101

• A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates.

  Scientia pharmaceutica 20110101

• Intraventricular glioneuronal tumor with disseminated lesions at diagnosis--a case report.

  Diagnostic pathology 20110101

• Postoperative deterioration in health related quality of life as predictor for survival in patients with glioblastoma: a prospective study.

  PloS one 20110101

• An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.

  PloS one 20110101

• BRAF in Melanoma: Pathogenesis, Diagnosis, Inhibition, and Resistance.

  Journal of skin cancer 20110101

• Spinal radiosurgery--efficacy and safety after prior conventional radiotherapy.

  Radiation oncology (London, England) 20110101

• Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide.

  BMC cancer 20110101

• Morphometic analysis of TCGA glioblastoma multiforme.

  BMC bioinformatics 20110101

• Radiotherapy and 'new' drugs-new side effects?

  Radiation oncology (London, England) 20110101

• The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia.

  Stem cells international 20110101

• Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment.

  Clinical & developmental immunology 20110101

• The immune response to tumors as a tool toward immunotherapy.

  Clinical & developmental immunology 20110101

• Skull base metastases from a malignant solitary fibrous tumor of the liver. A case report and literature review.

  Diagnostic pathology 20110101

• Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.

  PloS one 20110101

• Theranostic cRGD-BioShuttle Constructs Containing Temozolomide- and Cy7 For NIR-Imaging and Therapy.

  Theranostics 20110101

• Evaluation of cancer stem cell migration using compartmentalizing microfluidic devices and live cell imaging.

  Journal of visualized experiments : JoVE 20110101

• Two cases of cerebral sinus venous thrombosis following chemotherapy for non-seminomatous germ cell tumor.

  Case reports in oncology 20110101

• Adjuvant therapy: melanoma.

  Journal of skin cancer 20110101

• Radioembolization in the treatment of neuroendocrine tumor metastases to the liver.

  International journal of hepatology 20110101

• [Brain metastasis in breast cancer].

  Voprosy onkologii 20110101

• Neurosurgery concepts.

  Surgical neurology international 20110101

• Profile of ipilimumab and its role in the treatment of metastatic melanoma.

  Drug design, development and therapy 20110101

• Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A.

  International journal of molecular sciences 20110101

• Emerging roles of glycogen synthase kinase 3 in the treatment of brain tumors.

  Frontiers in molecular neuroscience 20110101

• The state of research into children with cancer across Europe: new policies for a new decade.

  Ecancermedicalscience 20110101

• Typical bronchial carcinoid metastasizing to the brain: a case presentation.

  Case reports in oncology 20110101

• The prospective role of plant products in radiotherapy of cancer: a current overview.

  Frontiers in pharmacology 20110101

• Cisplatin tumor biodistribution and efficacy after intratumoral injection of a biodegradable extended release implant.

  Chemotherapy research and practice 20110101

• New agents targeting angiogenesis in glioblastoma.

  Chemotherapy research and practice 20110101

• Autophagy: friend or foe in breast cancer development, progression, and treatment.

  International journal of breast cancer 20110101

• Bevacizumab improves quality of life in patients with recurrent glioblastoma.

  Chemotherapy research and practice 20110101

• Triple-negative breast cancer: adjuvant therapeutic options.

  Chemotherapy research and practice 20110101

• Glioma Indian scenario: Is there a human leucocyte antigen association?

  Journal of natural science, biology, and medicine 20110101

• Ion channels in glioblastoma.

  ISRN neurology 20110101

• Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery.

  Frontiers in immunology 20110101

• Integration of Principles of Systems Biology and Radiation Biology: Toward Development of in silico Models to Optimize IUdR-Mediated Radiosensitization of DNA Mismatch Repair Deficient (Damage Tolerant) Human Cancers.

  Frontiers in oncology 20110101

• Frontiers in cancer endocrinology.

  Frontiers in endocrinology 20110101

• Combined modality approaches in the management of adult glioblastoma.

  Frontiers in oncology 20110101

• Post-transcriptional regulation of O(6)-methylguanine-DNA methyltransferase MGMT in glioblastomas.

  Cancer biomarkers : section A of Disease markers 20110101

• CXCR4-positive subset of glioma is enriched for cancer stem cells.

  Oncology research 20110101

• Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.

  The Journal of biological chemistry 20101224

• Synthesis and antitumor activity of 3-methyl-4-oxo-3,4-dihydroimidazo [5,1-d][1,2,3,5]tetrazine-8-carboxylates and -carboxamides.

  Molecules (Basel, Switzerland) 20101220

• Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.

  The Journal of biological chemistry 20101217

• Non-stem cell origin for oligodendroglioma.

  Cancer cell 20101214

• Brain metastases from melanoma: is there a role for concurrent temozolomide in addition to whole brain radiation therapy?

  American journal of clinical oncology 20101201

• Tonsillar pseudotumor: complications of chronically-administered temozolomide.

  Journal of neuro-oncology 20101201

• Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma.

  Journal of neuro-oncology 20101201

• Nitrosourea-based chemotherapy for low grade gliomas failing initial treatment with temozolomide.

  Journal of neuro-oncology 20101201

• Receptor activation and inhibition in cellular response to chemotherapeutic combinational mimicries: the concept of divergent targeting.

  Journal of neuro-oncology 20101201

• Autophagy and tumorigenesis.

  Seminars in immunopathology 20101201

• Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children's Oncology Group.

  Pediatric blood & cancer 20101201

• Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma.

  European journal of cancer (Oxford, England : 1990) 20101201

• A multi-centre Canadian pilot study of metronomic temozolomide combined with radiotherapy for newly diagnosed paediatric brainstem glioma.

  European journal of cancer (Oxford, England : 1990) 20101201

• MGMT immunoexpression in aggressive pituitary adenoma and carcinoma.

  Pituitary 20101201

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Postoperative radiotherapy and concomitant temozolomide for elderly patients with glioblastoma.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20101201

• Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20101201

• [Glioblastoma incident studies from May 2006 to May 2007 in Angers and Nice, France].

  Neuro-Chirurgie 20101201

• Salvage therapy with temozolomide in patients with aggressive or metastatic pituitary adenomas: experience in six cases.

  European journal of endocrinology 20101201

• Unsuccessful high dose IL-2 therapy followed immediately by near continuous low dose temozolomide can result in rapid durable complete and near-complete remissions in metastatic melanoma.

  Cancer biology & therapy 20101201

• Malignant melanoma as a target malignancy for the study of the anti-metastatic properties of the heparins.

  Cancer metastasis reviews 20101201

• Temozolomide for adult brain stem glioblastoma: case report of a long-term survivor.

  The International journal of neuroscience 20101201

• Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20101201

• [Chemotherapy and targeted treatments in glioblastomas].

  Neuro-Chirurgie 20101201

• Glioblastoma: synergy of growth promotion between CCL5 and NK-1R can be thwarted by blocking CCL5 with miraviroc, an FDA approved anti-HIV drug and blocking NK-1R with aprepitant, an FDA approved anti-nausea drug.

  Journal of clinical pharmacy and therapeutics 20101201

• Low immunohistochemical expression of MGMT in ACTH secreting pituitary tumors of patients with Nelson syndrome.

  Endocrine pathology 20101201

• O6-methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: first Indian report with review of challenges for use in customized treatment.

  Neurosurgery 20101201

• FDA accelerated approval benefits glioblastoma.

  The Lancet. Oncology 20101201

• The tumor-immune microenvironment and response to radiation therapy.

  Journal of mammary gland biology and neoplasia 20101201

• Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation.

  Anti-cancer agents in medicinal chemistry 20101201

• AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers.

  Oncotarget 20101201

• miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis.

  Oncotarget 20101201

• Pseudoprogression following concurrent temozolomide and radiotherapy in a patient with glioblastoma: findings on functional imaging techniques.

  Fukuoka igaku zasshi = Hukuoka acta medica 20101201

• DecisionDx-GBM Gene Expression Assay for Prognostic Testing in Glioblastoma Multiform.

  PLoS currents 20101126

• What role should cilengitide have in the treatment of glioblastoma?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101120

• Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme.

  International journal of cancer 20101115

• Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma.

  International journal of radiation oncology, biology, physics 20101115

• Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risks.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20101115

• MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature.

  Cancer research 20101115

• [Carcinoid tumors].

  Orvosi hetilap 20101114

• Phase II trial of sagopilone, a novel epothilone analog in metastatic melanoma.

  British journal of cancer 20101109

• Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies.

  British journal of cancer 20101109

• Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.

  British journal of cancer 20101109

• Long-term adjuvant administration of temozolomide in patients with glioblastoma multiforme: experience of a single institution.

  Journal of cancer research and clinical oncology 20101101

• A prospective study of temozolomide plus thalidomide during and after radiation therapy for pediatric diffuse pontine gliomas: preliminary results of the Korean Society for Pediatric Neuro-Oncology study.

  Journal of neuro-oncology 20101101

• Temozolomide delivery to tumor cells by a multifunctional nano vehicle based on poly(β-L-malic acid).

  Pharmaceutical research 20101101

• Phase I/II dose escalation trial of concurrent temozolomide and whole brain radiation therapy for multiple brain metastasis.

  Journal of neuro-oncology 20101101

• Expression of CD74 in high grade gliomas: a potential role in temozolomide resistance.

  Journal of neuro-oncology 20101101

• KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells.

  Brain pathology (Zurich, Switzerland) 20101101

• SOM230 (pasireotide) and temozolomide achieve sustained control of tumour progression and ACTH secretion in pituitary carcinoma with widespread metastases.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20101101

• Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells.

  Gene therapy 20101101

• Phase I study of temozolomide combined with oral etoposide in children with recurrent or progressive medulloblastoma.

  European journal of cancer (Oxford, England : 1990) 20101101

• Management of ErbB2-positive breast cancer: insights from preclinical and clinical studies with lapatinib.

  Japanese journal of clinical oncology 20101101

• Can high-dose fotemustine reverse MGMT resistance in glioblastoma multiforme?

  Journal of neuro-oncology 20101101

• Mouse models of cancers: opportunities to address heterogeneity of human cancer and evaluate therapeutic strategies.

  Journal of molecular medicine (Berlin, Germany) 20101101

• MGMT gene promoter methylation in pediatric glioblastomas.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20101101

• The use of temozolomide for the treatment of malignant tumors: clinical evidence and molecular mechanisms of action.

  Recent patents on anti-cancer drug discovery 20101101

• Rash in four patients with brain tumor-related epilepsy in monotherapy with oxcarbazepine, during radiotherapy.

  Journal of neurology 20101101

• Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.

  Biochemical pharmacology 20101101

• Molecular diagnostics of gliomas: state of the art.

  Acta neuropathologica 20101101

• Targeting poly(ADP-ribose) polymerase activity for cancer therapy.

  Cellular and molecular life sciences : CMLS 20101101

• A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma.

  Neuro-oncology 20101101

• Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.

  Molecular pharmacology 20101101

• Small molecule inhibitors of DNA repair nuclease activities of APE1.

  Cellular and molecular life sciences : CMLS 20101101

• Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101101

• Prolonged survival of a patient with cervical intramedullary glioblastoma multiforme treated with total resection, radiation therapy, and temozolomide.

  Anti-cancer drugs 20101101

• Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101101

• Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.

  Archives of toxicology 20101101

• [Unknown gonadotoxicity chemotherapy and preservation of fertility: example of Temozolomide].

  Gynecologie, obstetrique & fertilite 20101101

• Neuro-oncology, a decade of temozolomide and beyond.

  Expert review of anticancer therapy 20101101

• [Malignant gliomas].

  Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20101101

• Human health risk assessment of pharmaceuticals in water: issues and challenges ahead.

  International journal of environmental research and public health 20101101

• Biodegradable microfibers deliver the antitumor drug temozolomide to glioma C6 cells in vitro.

  Die Pharmazie 20101101

• Temozolomide: Expanding its role in brain cancer.

  Drugs of today (Barcelona, Spain : 1998) 20101101

• Topoisomerase I inhibitors in the treatment of primary CNS malignancies: an update on recent trends.

  Anti-cancer agents in medicinal chemistry 20101101

• Targeted toxins in brain tumor therapy.

  Toxins 20101101

• Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres.

  Cancer letters 20101028

• miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells.

  Cancer letters 20101028

• Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models.

  British journal of cancer 20101026

• IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.

  Neurology 20101026

• Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101020

• How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine.

  British journal of cancer 20101012

• Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation.

  British journal of cancer 20101012

• Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line.

  Chemico-biological interactions 20101006

• Simultaneous integrated boost intensity-modulated radiotherapy in patients with high-grade gliomas.

  International journal of radiation oncology, biology, physics 20101001

• Leptomeningeal gliomatosis as the initial presentation of gliomatosis cerebri.

  Journal of neuro-oncology 20101001

• Steroid requirements during radiotherapy for malignant gliomas.

  Journal of neuro-oncology 20101001

• Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update.

  Journal of neuro-oncology 20101001

• The expression of mismatch repair proteins MLH1, MSH2 and MSH6 correlates with the Ki67 proliferation index and survival in patients with recurrent glioblastoma.

  Neurological research 20101001

• Intracerebral hemorrhage secondary to thrombocytopenia in a patient treated with temozolomide.

  Clinical neurology and neurosurgery 20101001

• Prolonged response without prolonged chemotherapy: a lesson from PCV chemotherapy in low-grade gliomas.

  Neuro-oncology 20101001

• Experimental approaches for the treatment of malignant gliomas.

  Pharmacology & therapeutics 20101001

• Phase I study of topotecan in combination with temozolomide (TOTEM) in relapsed or refractory paediatric solid tumours.

  European journal of cancer (Oxford, England : 1990) 20101001

• A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma.

  Neuro-oncology 20101001

• Radiation induced early necrosis in patients with malignant gliomas receiving temozolomide.

  Clinical neurology and neurosurgery 20101001

• Core-shell hybrid nanogels for integration of optical temperature-sensing, targeted tumor cell imaging, and combined chemo-photothermal treatment.

  Biomaterials 20101001

• Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: a French multicenter experience.

  The Journal of clinical endocrinology and metabolism 20101001

• Nelson's syndrome.

  European journal of endocrinology 20101001

• First-line treatment of malignant glioma with carmustine implants followed by concomitant radiochemotherapy: a multicenter experience.

  Neurosurgical review 20101001

• Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult glioma.

  Cancer research 20101001

• Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy.

  Oncology reports 20101001

• In vitro novel combinations of psychotropics and anti-cancer modalities in U87 human glioblastoma cells.

  International journal of oncology 20101001

• Ewing's sarcoma.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101001

• Leptomeningeal metastases from small cell lung cancer responsive to temozolomide therapy.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20101001

• Oncolytic adenoviruses for the treatment of brain tumors.

  Current opinion in molecular therapeutics 20101001

• Temozolomide: therapeutic limitations in the treatment of adult high-grade gliomas.

  Expert review of neurotherapeutics 20101001

• Single-arm phase II study of conformal radiation therapy and temozolomide plus fractionated stereotactic conformal boost in high-grade gliomas: final report.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20101001

• Brain metastasis in melanoma: clinical activity of CTLA-4 antibody therapy.

  Seminars in oncology 20101001

• An activating transcription factor 5-mediated survival pathway as a target for cancer therapy?

  Oncotarget 20101001

• Pediatric primary intramedullary spinal cord glioblastoma.

  Rare tumors 20100930

• Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.

  Oncogene 20100923

• MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity.

  Brain research 20100917

• MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome.

  British journal of cancer 20100907

• Combination of temozolomide with immunocytokine F16-IL2 for the treatment of glioblastoma.

  British journal of cancer 20100907

• Prognostic and predictive value of p53 in low MGMT expressing glioblastoma treated with surgery, radiation and adjuvant temozolomide chemotherapy.

  Neurological research 20100901

• alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells.

  International journal of cancer 20100901

• Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma.

  International journal of radiation oncology, biology, physics 20100901

• Integration of autologous dendritic cell-based immunotherapy in the primary treatment for patients with newly diagnosed glioblastoma multiforme: a pilot study.

  Journal of neuro-oncology 20100901

• MGMT immunoexpression in silent subtype 3 pituitary adenomas: possible therapeutic implications.

  Endocrine pathology 20100901

• Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme.

  Neuro-oncology 20100901

• Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.

  The Journal of pharmacology and experimental therapeutics 20100901

• Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas.

  Cancer gene therapy 20100901

• Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide.

  Neuro-oncology 20100901

• Temozolomide (Temodar).

  AJNR. American journal of neuroradiology 20100901

• Comment on 'Non-surgical treatment of hormone-secreting pituitary tumors'.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100901

• Brain tumor stem cells as therapeutic targets in models of glioma.

  Yonsei medical journal 20100901

• Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician's perspective.

  Acta neuropathologica 20100901

• Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation.

  Pediatric blood & cancer 20100901

• American Association for Cancer Research Genetics and Biology of Brain Cancers 2009, December 13-15, 2009, San Diego, CA.

  Journal of neuro-oncology 20100901

• Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence.

  Cancer research 20100901

• Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression.

  Neoplasia (New York, N.Y.) 20100901

• Urticarial hypersensitivity reaction caused by temozolomide.

  Journal of drugs in dermatology : JDD 20100901

• Positron emission tomography/computed tomography: use for initial staging of malignant melanoma.

  International journal of dermatology 20100901

• Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?

  Future oncology (London, England) 20100901

• Glioblastoma multiforme in childhood: a case report.

  Clinics (Sao Paulo, Brazil) 20100901

• Clinical significance of molecular biomarkers in glioblastoma.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20100901

• Effect of alternative temozolomide schedules on glioblastoma O(6)-methylguanine-DNA methyltransferase activity and survival.

  British journal of cancer 20100810

• Current treatment strategies for brain metastasis and complications from therapeutic techniques: a review of current literature.

  American journal of clinical oncology 20100801

• Trans-sodium crocetinate enhancing survival and glioma response on magnetic resonance imaging to radiation and temozolomide.

  Journal of neurosurgery 20100801

• Up-front temozolomide in elderly patients with glioblastoma.

  Journal of neuro-oncology 20100801

• Bevacizumab and dose-intense temozolomide in recurrent high-grade glioma.

  Annals of oncology : official journal of the European Society for Medical Oncology 20100801

• Phase II trial of neoadjuvant temozolomide in resectable melanoma patients.

  Annals of oncology : official journal of the European Society for Medical Oncology 20100801

• MGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib.

  Neuro-oncology 20100801

• Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma.

  Annals of surgical oncology 20100801

• Genetic variations in EGF and EGFR and glioblastoma outcome.

  Neuro-oncology 20100801

• Role of temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: experience at a single institution.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20100801

• O(6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma.

  International journal of clinical oncology 20100801

• A Phase II study of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of glioblastoma multiforme.

  Journal of neurosurgery 20100801

• Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall.

  Acta neuropathologica 20100801

• mTOR signaling in glioblastoma: lessons learned from bench to bedside.

  Neuro-oncology 20100801

• DNA ligase IV is a potential molecular target in ACNU sensitivity.

  Cancer science 20100801

• Changes in relative cerebral blood volume 1 month after radiation-temozolomide therapy can help predict overall survival in patients with glioblastoma.

  Radiology 20100801

• Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiforme.

  Cancer 20100801

• Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastoma xenografts.

  The Tohoku journal of experimental medicine 20100801

• Influence of iMRI-guidance on the extent of resection and survival of patients with glioblastoma multiforme.

  Technology in cancer research & treatment 20100801

• [Neurological complications of neurooncological therapy].

  Der Nervenarzt 20100801

• [Anaplastic glioma. Neuropathology, molecular diagnostics and current study concepts].

  Der Nervenarzt 20100801

• Patterns of care and survival in a retrospective analysis of 1059 patients with glioblastoma multiforme treated between 2002 and 2007: a multicenter study by the Central Nervous System Study Group of Airo (italian Association of Radiation Oncology).

  Neurosurgery 20100801

• Long-term outcomes in children with glioblastoma.

  Journal of neurosurgery. Pediatrics 20100801

• Rational use of anticancer drugs and patient lawsuits in the state of São Paulo, Southeastern Brazil.

  Revista de saude publica 20100801

• Aplastic anemia with concurrent temozolomide treatment in a patient with glioblastoma multiforme.

  Current oncology (Toronto, Ont.) 20100801

• Malignant progression of a pleomorphic xanthoastrocytoma in a child.

  Neuropediatrics 20100801

• Aplastic anemia as a cause of death in a patient with glioblastoma multiforme treated with temozolomide.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20100801

• Pegylated IFN-α sensitizes melanoma cells to chemotherapy and causes premature senescence in endothelial cells by IRF-1 mediated signaling.

  Cell death & disease 20100801

• TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy.

  British journal of cancer 20100727

• Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide.

  International journal of radiation oncology, biology, physics 20100701

• Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy: a single institution cohort.

  Journal of neuro-oncology 20100701

• Treatment and outcome of children with relapsed ependymoma: a multi-institutional retrospective analysis.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20100701

• The DNA methylome of glioblastoma multiforme.

  Neurobiology of disease 20100701

• Can hsp90alpha-targeted siRNA combined with TMZ be a future therapy for glioma?

  Cancer investigation 20100701

• Far-distant metastases along the CSF pathway of glioblastoma multiforme during continuous low-dose chemotherapy with temozolomide and celecoxib.

  Neurosurgical review 20100701

• Oncological patterns of care and outcome for 952 patients with newly diagnosed glioblastoma in 2004.

  Neuro-oncology 20100701

• Sensitivity to temozolomide in brain tumor initiating cells.

  Neuro-oncology 20100701

• Extended phase I evaluation of vincristine, irinotecan, temozolomide, and antibiotic in children with refractory solid tumors.

  Pediatric blood & cancer 20100701

• Carmustine wafers (Gliadel) plus concomitant temozolomide therapy after resection of malignant astrocytoma: growing evidence for safety and efficacy.

  Annals of surgical oncology 20100701

• Biodegradable carmustine wafers (Gliadel) alone or in combination with chemoradiotherapy: the French experience.

  Annals of surgical oncology 20100701

• New drugs in neuroendocrine tumors: rising of new therapeutic philosophies?

  Current opinion in oncology 20100701

• Stratifying osteosarcoma: minimizing and maximizing therapy.

  Current oncology reports 20100701

• Initial experience involving treatment and retreatment with carmustine wafers in combination with oral temozolomide: long-term survival in a child with relapsed glioblastoma multiforme.

  Journal of pediatric hematology/oncology 20100701

• PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

  Cancer research 20100701

• Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival.

  Journal of neuropathology and experimental neurology 20100701

• Long-term survival in patients with metastatic melanoma treated with DTIC or temozolomide.

  The oncologist 20100701

• Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy.

  Molecular cancer therapeutics 20100701

• The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma.

  Molecular cancer research : MCR 20100701

• Boron neutron capture therapy for newly diagnosed glioblastoma multiforme: an assessment of clinical potential.

  The British journal of radiology 20100701

• Analysis and stability study of temozolomide using capillary electrophoresis.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100701

• Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

  Oncotarget 20100701

• Newly diagnosed high-grade gliomas.

  Current treatment options in neurology 20100701

• Recurrent high-grade glioma.

  Current treatment options in neurology 20100701

• [Pituitary adenomas--where is the treatment heading at the beginning of the 21st century?].

  Vnitrni lekarstvi 20100701

• Capecitabine and temozolomide: design, implementation, and preliminary outcomes from a pilot project to ensure safe prescribing of oral chemotherapy.

  Journal of oncology practice 20100701

• Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma.

  Neuroscience 20100630

• Gliosarcoma: a study of four cases.

  Rare tumors 20100630

• Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide.

  British journal of cancer 20100629

• Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100615

• Dose-dense temozolomide regimens: antitumor activity, toxicity, and immunomodulatory effects.

  Cancer 20100615

• Recurrent pituitary ependymoma: a complex clinical problem.

  Pituitary 20100601

• O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers.

  Lung cancer (Amsterdam, Netherlands) 20100601

• Concurrent temozolomide and radiation, a reasonable option for elderly patients with glioblastoma multiforme?

  American journal of clinical oncology 20100601

• Systematic analysis of the antiproliferative effects of novel and standard anticancer agents in rhabdoid tumor cell lines.

  Anti-cancer drugs 20100601

• Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: a phase I study.

  Neuro-oncology 20100601

• Impact of splenectomy on thrombocytopenia, chemotherapy, and survival in patients with unresectable pancreatic cancer.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20100601

• Gene expression profiling predicts response to temozolomide in malignant gliomas.

  International journal of oncology 20100601

• Prognostic value of MGMT promoter methylation in glioblastoma patients treated with temozolomide-based chemoradiation: a Portuguese multicentre study.

  Oncology reports 20100601

• Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100601

• Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent.

  Current cancer drug targets 20100601

• Phase I study of temozolomide and laromustine (VNP40101M) in patients with relapsed or refractory leukemia.

  Clinical lymphoma, myeloma & leukemia 20100601

• Prolonged survival for patients with newly diagnosed, inoperable glioblastoma with 3-times daily ultrafractionated radiation therapy.

  Neuro-oncology 20100601

• Targeted therapies in renal cell cancer: recent developments in imaging.

  Targeted oncology 20100601

• The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases.

  Current genomics 20100601

• Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100515

• Prospective evaluation of radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma.

  International journal of radiation oncology, biology, physics 20100501

• A phase I dose-escalation study (ISIDE-BT-1) of accelerated IMRT with temozolomide in patients with glioblastoma.

  International journal of radiation oncology, biology, physics 20100501

• A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiforme.

  Journal of neurosurgery 20100501

• Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patients.

  Journal of neurosurgery 20100501

• Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status.

  Journal of neuro-oncology 20100501

• Prognostic value of O6-methylguanine-DNA methyltransferase status in glioblastoma patients, assessed by five different methods.

  Journal of neuro-oncology 20100501

• Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination.

  Journal of neuro-oncology 20100501

• Compartmental intrathecal radioimmunotherapy: results for treatment for metastatic CNS neuroblastoma.

  Journal of neuro-oncology 20100501

• A case of primary leptomeningeal gliomatosis confined to the spinal cord.

  Journal of neuro-oncology 20100501

• Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue.

  Journal of neuro-oncology 20100501

• High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system.

  Journal of neuro-oncology 20100501

• Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme.

  Journal of neuro-oncology 20100501

• The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound.

  Pharmacological research 20100501

• Cordectomy as final treatment option for diffuse intramedullary malignant glioma using 5-ALA fluorescence-guided resection.

  Clinical neurology and neurosurgery 20100501

• Loss of 1p, 19q, and 10q heterozygosity prospectively predicts prognosis of oligodendroglial tumors--towards individualized tumor treatment?

  Neuro-oncology 20100501

• Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma.

  Stem cells (Dayton, Ohio) 20100501

• Effects of concomitant temozolomide and radiation therapies on WT1-specific T-cells in malignant glioma.

  Japanese journal of clinical oncology 20100501

• Parametric response map as an imaging biomarker to distinguish progression from pseudoprogression in high-grade glioma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100501

• Changes of the O6-methylguanine-DNA methyltransferase promoter methylation and MGMT protein expression after adjuvant treatment in glioblastoma.

  Oncology reports 20100501

• Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20100501

• A phase II trial of primary temozolomide in patients with grade III oligodendroglial brain tumors.

  Neuro-oncology 20100501

• Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial.

  Neuro-oncology 20100501

• Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity.

  Molecular cancer therapeutics 20100501

• Management of low-grade glioma.

  Current neurology and neuroscience reports 20100501

• Pseudoprogression after radiotherapy with concurrent temozolomide in a child with anaplastic astrocytoma.

  Pediatric hematology and oncology 20100501

• Malignant transformation of an optic pathway glioma without prior radiation therapy.

  Journal of neurosurgery. Pediatrics 20100501

• Whole-brain radiation therapy plus concomitant temozolomide for the treatment of brain metastases from non-small-cell lung cancer: a randomized, open-label phase II study.

  Clinical lung cancer 20100501

• Paternalism in practice: informing patients about expensive unsubsidised drugs.

  Journal of medical ethics 20100501

• Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression.

  Molecular cancer therapeutics 20100501

• High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

  Annals of oncology : official journal of the European Society for Medical Oncology 20100501

• From then to now: lessons from developments in our understanding of the pituitary gland.

  The Ulster medical journal 20100501

• Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.

  Journal of medicinal chemistry 20100422

• Therapy for recurrent high-grade gliomas: does continuous dose-intense temozolomide have a role?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100420

• Phase II trial of continuous dose-intense temozolomide in recurrent malignant glioma: RESCUE study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100420

• Commentary on Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial (Lancet Oncol. 2009;10:459-466).

  Cancer 20100415

• Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts.

  Cancer research 20100415

• Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100415

• Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100415

• The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects.

  Cancer research 20100415

• Determinants of survival in patients with brain metastases from cutaneous melanoma.

  British journal of cancer 20100413

• Immunotherapy of pediatric brain tumor patients should include an immunoprevention strategy: a medical hypothesis paper.

  Journal of neuro-oncology 20100401

• Phase I trial of two schedules of vincristine, oral irinotecan, and temozolomide (VOIT) for children with relapsed or refractory solid tumors: a Children's Oncology Group phase I consortium study.

  Pediatric blood & cancer 20100401

• Temozolomide and cisplatin combination in naive patients with metastatic cutaneous melanoma: results of a phase II multicenter trial.

  Melanoma research 20100401

• In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery.

  Biomaterials 20100401

• The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma.

  Acta neuropathologica 20100401

• Myasthenia gravis developing in a patient with CNS lymphoma.

  International journal of hematology 20100401

• An international validation study of the EORTC brain cancer module (EORTC QLQ-BN20) for assessing health-related quality of life and symptoms in brain cancer patients.

  European journal of cancer (Oxford, England : 1990) 20100401

• PARP inhibition: PARP1 and beyond.

  Nature reviews. Cancer 20100401

• A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.

  Cancer research 20100401

• Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines.

  Neuro-oncology 20100401

• Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing.

  Neuro-oncology 20100401

• Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells.

  Neuro-oncology 20100401

• Transferrin receptor 2 is frequently and highly expressed in glioblastomas.

  Translational oncology 20100401

• Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.

  Molecular cancer therapeutics 20100401

• Recent advances in combined modality therapy.

  The oncologist 20100401

• Flow cytometric analysis for the mechanism of the new antineoplastic agent temozolomide in glioma cells.

  Brain tumor pathology 20100401

• Pharmacogenetic application in personalized cancer treatment.

  Acta medica Indonesiana 20100401

• Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases.

  Neurosurgical review 20100401

• Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours.

  British journal of cancer 20100330

• Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis.

  British journal of cancer 20100330

• In vivo assessment of temozolomide local delivery for lung cancer inhalation therapy.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100318

• Neuroendocrine tumors of the pancreas: what's new. Highlights from the '2010 ASCO Gastrointestinal Cancers Symposium'. Orlando, FL, USA. January 22-24, 2010.

  JOP : Journal of the pancreas 20100305

• [Glioblastoma multiforme--new hope due to modern therapeutical approaches].

  Praxis 20100303

• Evaluation of the exposure equivalence of oral versus intravenous temozolomide.

  Cancer chemotherapy and pharmacology 20100301

• Radiotherapy and concomitant temozolomide during the first and last weeks in high grade gliomas: long-term analysis of a phase II study.

  Journal of neuro-oncology 20100301

• Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival.

  Journal of neuro-oncology 20100301

• Cognitive functioning in glioblastoma patients during radiotherapy and temozolomide treatment: initial findings.

  Journal of neuro-oncology 20100301

• Dose-dense temozolomide regimen for the treatment of brain metastases from melanoma, breast cancer, or lung cancer not amenable to surgery or radiosurgery: a multicenter phase II study.

  Annals of oncology : official journal of the European Society for Medical Oncology 20100301

• Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O(6)-methylguanine-DNA methyltransferase(P140K).

  Gene therapy 20100301

• Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients.

  Cancer 20100301

• Comment on 'Opportunistic cytomegalovirus infection in a patient receiving temozolomide for treatment of malignant glioma'.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100301

• Temozolomide and MGMT forever?

  Neuro-oncology 20100301

• Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice.

  Neuro-oncology 20100301

• Six-month progression-free survival as an alternative primary efficacy endpoint to overall survival in newly diagnosed glioblastoma patients receiving temozolomide.

  Neuro-oncology 20100301

• O(6)-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications.

  Neuro-oncology 20100301

• Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma.

  Neuro-oncology 20100301

• Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies.

  Neuro-oncology 20100301

• Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model.

  Neurosurgery 20100301

• Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100301

• Patent watch.

  Nature reviews. Drug discovery 20100301

• The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway.

  Journal of cell communication and signaling 20100301

• Recent advances in therapy for glioblastoma.

  Archives of neurology 20100301

• Bevacizumab for malignant gliomas.

  Archives of neurology 20100301

• A phase 1 trial of ABT-510 concurrent with standard chemoradiation for patients with newly diagnosed glioblastoma.

  Archives of neurology 20100301

• Amelioration of symptoms and reduction of VIP levels after hepatic artery chemoembolization in a patient with sandostatin resistant VIPoma.

  The Yale journal of biology and medicine 20100301

• Effectiveness of temozolomide treatment used at the same time with radiotherapy and adjuvant temozolomide; concomitant therapy of glioblastoma multiforme: multivariate analysis and other prognostic factors.

  Journal of neurosurgical sciences 20100301

• The role of cytotoxic drugs in the treatment of central nervous system gliomas.

  Acta neurologica Belgica 20100301

• Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.

  The Journal of biological chemistry 20100219

• Treatment options for small cell lung cancer - do we have more choice?

  British journal of cancer 20100216

• A mathematical model of brain tumour response to radiotherapy and chemotherapy considering radiobiological aspects.

  Journal of theoretical biology 20100207

• Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity.

  Journal of neuro-oncology 20100201

• Different molecular patterns in glioblastoma multiforme subtypes upon recurrence.

  Journal of neuro-oncology 20100201

• Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone.

  Journal of neuro-oncology 20100201

• Extended-schedule dose-dense temozolomide in refractory gliomas.

  Journal of neuro-oncology 20100201

• Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide.

  Journal of neuro-oncology 20100201

• MGMT as a potential stratification marker in relapsed high-grade glioma of children: the HIT-GBM experience.

  Pediatric blood & cancer 20100201

• Protein tyrosine phosphatases in glioma biology.

  Acta neuropathologica 20100201

• The clinical efficacy of combination of docetaxel and temozolomide in previously treated patients with stage IV melanoma.

  Melanoma research 20100201

• O-methylguanine-DNA methyltransferase immunoexpression in a double pituitary adenoma: case report.

  Neurosurgery 20100201

• Interleukin-29 binds to melanoma cells inducing Jak-STAT signal transduction and apoptosis.

  Molecular cancer therapeutics 20100201

• Mitogen-activated protein/extracellular signal-regulated kinase kinase inhibition results in biphasic alteration of epidermal homeostasis with keratinocytic apoptosis and pigmentation disorders.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100201

• Medical oncology: treatment and management of malignant gliomas.

  Nature reviews. Clinical oncology 20100201

• Patient-tailored, imaging-guided, long-term temozolomide chemotherapy in patients with glioblastoma.

  Molecular imaging 20100201

• Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma.

  Neuro-oncology 20100201

• The timing of cranial radiation in elderly patients with newly diagnosed glioblastoma multiforme.

  Neuro-oncology 20100201

• Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells.

  Translational oncology 20100201

• Targeting A20 decreases glioma stem cell survival and tumor growth.

  PLoS biology 20100201

• [Treatment of clinically nonfunctioning pituitary adenomas].

  Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100201

• Effects of interleukin-1 receptor antagonist and chemotherapy on host-tumor interactions in established melanoma.

  Anticancer research 20100201

• Bevacizumab is active as a single agent against recurrent malignant gliomas.

  Anticancer research 20100201

• Clinical features, management and outcomes of high-grade glioma patients in Ramathibodi Hospital.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100201

• The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells.

  Toxicology 20100131

• Phase 2 trial of combination thalidomide plus temozolomide in patients with metastatic malignant melanoma: Southwest Oncology Group S0508.

  Cancer 20100115

• Galectins and gliomas.

  Brain pathology (Zurich, Switzerland) 20100101

• Inhibition of 90-kD heat shock protein potentiates the cytotoxicity of chemotherapeutic agents in human glioma cells.

  Journal of neurosurgery 20100101

• [11C]-L-methionine positron emission tomography in the management of children and young adults with brain tumors.

  Journal of neuro-oncology 20100101

• Primary brain T-cell lymphoma of the lymphoblastic type presenting as altered mental status.

  Acta neurochirurgica 20100101

• Effectiveness of temozolomide for primary glioblastoma multiforme in routine clinical practice.

  Journal of neuro-oncology 20100101

• A human brainstem glioma xenograft model enabled for bioluminescence imaging.

  Journal of neuro-oncology 20100101

• Salvage therapy with single agent bevacizumab for recurrent glioblastoma.

  Journal of neuro-oncology 20100101

• Comparing neuropsychological tasks to optimize brief cognitive batteries for brain tumor clinical trials.

  Journal of neuro-oncology 20100101

• Glioblastoma in elderly patients: safety and efficacy of adjuvant radiotherapy with concomitant temozolomide.

  Archives of gerontology and geriatrics 20100101

• Volumetry of [(11)C]-methionine PET uptake and MRI contrast enhancement in patients with recurrent glioblastoma multiforme.

  European journal of nuclear medicine and molecular imaging 20100101

• Rapid response to therapy of neurocutaneous melanosis with leptomeningeal melanoma.

  Pediatric blood & cancer 20100101

• Recurrent glioblastoma of childhood treated with bevacizumab: case report and molecular features.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20100101

• Phase II study of fixed dose rate gemcitabine as radiosensitizer for newly diagnosed glioblastoma multiforme.

  Cancer chemotherapy and pharmacology 20100101

• Inter- and intrapatients comparison of WHO grade II glioma kinetics before and after surgical resection.

  Neurosurgical review 20100101

• Concomitant or adjuvant temozolomide with whole-brain irradiation for brain metastases: a meta-analysis.

  Anti-cancer drugs 20100101

• Oral atovaquone for the treatment of severe Pneumocystis jirovecii pneumonia in a patient with glucose-6-phosphate dehydrogenase deficiency.

  Scandinavian journal of infectious diseases 20100101

• Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma model.

  Clinical and vaccine immunology : CVI 20100101

• Engineered drug-resistant immunocompetent cells enhance tumor cell killing during a chemotherapy challenge.

  Biochemical and biophysical research communications 20100101

• EORTC study 26041-22041: phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma.

  European journal of cancer (Oxford, England : 1990) 20100101

• The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics.

  Journal of neuro-oncology 20100101

• The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline.

  Journal of neuro-oncology 20100101

• The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline.

  Journal of neuro-oncology 20100101

• The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline.

  Journal of neuro-oncology 20100101

• Intra-arterial chemotherapy with osmotic blood-brain barrier disruption for aggressive oligodendroglial tumors: results of a phase I study.

  Neurosurgery 20100101

• A phase I trial of bortezomib with temozolomide in patients with advanced melanoma: toxicities, antitumor effects, and modulation of therapeutic targets.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100101

• Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.

  Cancer research 20100101

• Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges.

  Journal of oncology 20100101

• The Diels-Alder-reaction with inverse-electron-demand, a very efficient versatile click-reaction concept for proper ligation of variable molecular partners.

  International journal of medical sciences 20100101

• The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100101

• The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer.

  Journal of oncology 20100101

• Residual gammaH2AX foci as an indication of lethal DNA lesions.

  BMC cancer 20100101

• Esthesioneuroblastoma (Olfactory Neuroblastoma) with Ectopic ACTH Syndrome: a multidisciplinary case presentation from the Joan Karnell cancer center of Pennsylvania Hospital.

  The oncologist 20100101

• Intravenously administered alphavirus vector VA7 eradicates orthotopic human glioma xenografts in nude mice.

  PloS one 20100101

• Long-term temozolomide treatment induces marked amino metabolism modifications and an increase in TMZ sensitivity in Hs683 oligodendroglioma cells.

  Neoplasia (New York, N.Y.) 20100101

• (-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma.

  Breast cancer research : BCR 20100101

• Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker.

  Molecular cancer 20100101

• A phase II trial of the epothilone B analog ixabepilone (BMS-247550) in patients with metastatic melanoma.

  PloS one 20100101

• Is there a place for radiotherapy in low-grade gliomas?

  Advances and technical standards in neurosurgery 20100101

• Evaluation of adenovirus capsid labeling versus transgene expression.

  Virology journal 20100101

• Bevacizumab: in previously treated glioblastoma.

  Drugs 20100101

• Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas.

  Radiation oncology (London, England) 20100101

• Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model.

  BMC cancer 20100101

• BCNU for recurrent glioblastoma multiforme: efficacy, toxicity and prognostic factors.

  BMC cancer 20100101

• U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line.

  PLoS genetics 20100101

• Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20100101

• A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI.

  Radiation oncology (London, England) 20100101

• From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.

  Journal of hematology & oncology 20100101

• O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients.

  Neuro-oncology 20100101

• Osteopontin regulates human glioma cell invasiveness and tumor growth in mice.

  Neuro-oncology 20100101

• Noninvasive detection of temozolomide in brain tumor xenografts by magnetic resonance spectroscopy.

  Neuro-oncology 20100101

• Incorporating BCNU wafers into malignant glioma treatment: European case studies.

  Clinical drug investigation 20100101

• Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference.

  BMC cancer 20100101

• Increased phosphorylation of vimentin in noninfiltrative meningiomas.

  PloS one 20100101

• Pseudoprogression following chemoradiotherapy for glioblastoma multiforme.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20100101

• Activated CD4+ T cells enhance radiation effect through the cooperation of interferon-gamma and TNF-alpha.

  BMC cancer 20100101

• A patient with metastatic melanoma presenting with gastrointestinal perforation after dacarbazine infusion: a case report.

  Journal of medical case reports 20100101

• CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors.

  BMC cancer 20100101

• BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.

  Journal of oncology 20100101

• Current therapeutic paradigms in glioblastoma.

  Reviews on recent clinical trials 20100101

• Polysialic acid neural cell adhesion molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines.

  BMC cancer 20100101

• Improved killing of human high-grade glioma cells by combining ionizing radiation with oncolytic parvovirus H-1 infection.

  Journal of biomedicine & biotechnology 20100101

• Temozolomide-induced myelodysplasia.

  Advances in hematology 20100101

• A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy.

  Molecular cancer 20100101

• MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients.

  Neoplasma 20100101

• Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications.

  Oncology 20100101

• Progress on antiangiogenic therapy for patients with malignant glioma.

  Journal of oncology 20100101

• Postoperative chemo-radiotherapy with temodal in patients with glioblastoma multiforme--survival rates and prognostic factors.

  Folia medica 20100101

• Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy.

  Molecular cancer 20100101

• The bright and the dark sides of DNA repair in stem cells.

  Journal of biomedicine & biotechnology 20100101

• Melanoma: a model for testing new agents in combination therapies.

  Journal of translational medicine 20100101

• Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report.

  Nutrition & metabolism 20100101

• Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma.

  Journal of oncology 20100101

• Molecular therapeutic targets for glioma angiogenesis.

  Journal of oncology 20100101

• Astrocytes derived from trisomic human embryonic stem cells express markers of astrocytic cancer cells and premalignant stem-like progenitors.

  BMC medical genomics 20100101

• Advances in the treatment of malignant gliomas.

  Current oncology reports 20100101

• Noncutaneous malignant melanoma: a prognostic model from a retrospective multicenter study.

  BMC cancer 20100101

• Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.

  PloS one 20100101

• Short-term radiotherapy followed by adjuvant chemotherapy in poor-prognosis patients with glioblastoma.

  Tumori 20100101

• Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications.

  Journal of carcinogenesis 20100101

• Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma.

  CA: a cancer journal for clinicians 20100101

• Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents.

  Journal of oncology 20100101

• Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms.

  Breast cancer research : BCR 20100101

• Forecasting drug utilization and expenditure in a metropolitan health region.

  BMC health services research 20100101

• Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma.

  BMC cancer 20100101

• Preoperative chemotherapy for infiltrative low-grade oligoastrocytoma: a useful strategy to maximize surgical resection -case report-.

  Neurologia medico-chirurgica 20100101

• Glioblastoma detected at the initial stage in its developmental process -case report-.

  Neurologia medico-chirurgica 20100101

• Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics.

  Molecular cancer 20100101

• Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors.

  PloS one 20100101

• Effects of bevacizumab plus irinotecan on response and survival in patients with recurrent malignant glioma: a systematic review and survival-gain analysis.

  BMC cancer 20100101

• Carmustine and methotrexate in combination after whole brain radiation therapy in breast cancer patients presenting with brain metastases: a retrospective study.

  BMC cancer 20100101

• CyberKnife enhanced conventionally fractionated chemoradiation for high grade glioma in close proximity to critical structures.

  Journal of hematology & oncology 20100101

• Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy.

  Molecular cancer 20100101

• T cells enhance stem-like properties and conditional malignancy in gliomas.

  PloS one 20100101

• Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies.

  Journal of translational medicine 20100101

• Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73.

  BMC cancer 20100101

• Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial.

  PloS one 20100101

• Health-related quality of life in glioma patients in China.

  BMC cancer 20100101

• Gain of a 500-fold sensitivity on an intravital MR contrast agent based on an endohedral gadolinium-cluster-fullerene-conjugate: a new chance in cancer diagnostics.

  International journal of medical sciences 20100101

• Hemorrhagic cystitis in a patient receiving docetaxel for prostate cancer.

  Clinical Medicine Insights. Oncology 20100101

• ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro.

  Molecular cancer 20100101

• A case of relapsed medulloblastoma treated with intensity-modulated radiotherapy and temozolomide.

  Tumori 20100101

• Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells.

  BMC cancer 20100101

• Mycobacterium bovis-BCG vaccination induces specific pulmonary transcriptome biosignatures in mice.

  PloS one 20100101

• Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells.

  PloS one 20100101

• CTLA-4 blockade: therapeutic potential in cancer treatments.

  OncoTargets and therapy 20100101

• New treatment options in the management of glioblastoma multiforme: a focus on bevacizumab.

  OncoTargets and therapy 20100101

• Anti-angiogenesis therapies: their potential in cancer management.

  OncoTargets and therapy 20100101

• Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry.

  International journal of medical sciences 20100101

• MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN.

  BMC cancer 20100101

• Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.

  Journal of oncology 20100101

• Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032.

  Journal of translational medicine 20100101

• Decreasing glioma recurrence through adjuvant cancer stem cell inhibition.

  Biologics : targets & therapy 20100101

• Angiogenesis and progression in human melanoma.

  Dermatology research and practice 20100101

• Establishing intracranial brain tumor xenografts with subsequent analysis of tumor growth and response to therapy using bioluminescence imaging.

  Journal of visualized experiments : JoVE 20100101

• Mesenchymal migration as a therapeutic target in glioblastoma.

  Journal of oncology 20100101

• Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma.

  BMC cancer 20100101

• Personalized therapies in the cancer 'omics' era.

  Molecular cancer 20100101

• Oxidative stress and DNA methylation in prostate cancer.

  Obstetrics and gynecology international 20100101

• Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability.

  Genome integrity 20100101

• [Side effects of temozolomide treatment in patient with glioblastoma multiforme--case study].

  Przeglad lekarski 20100101

• Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct.

  Journal of neuroinflammation 20100101

• Impact of adjuvant chemotherapy for gliomatosis cerebri.

  BMC cancer 20100101

• Targeted Therapy Database (TTD): a model to match patient's molecular profile with current knowledge on cancer biology.

  PloS one 20100101

• Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-alpha 2b treatment.

  Journal of translational medicine 20100101

• Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report.

  Journal of medical case reports 20100101

• Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas.

  BMC cancer 20100101

• Low peripheral lymphocyte count before focal radiotherapy plus concomitant temozolomide predicts severe lymphopenia during malignant glioma treatment.

  Neurologia medico-chirurgica 20100101

• Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report.

  Neurologia medico-chirurgica 20100101

• Pituitary carcinoma diagnosed on fine needle aspiration: Report of a case and review of pathogenesis.

  CytoJournal 20100101

• MRP3: a molecular target for human glioblastoma multiforme immunotherapy.

  BMC cancer 20100101

• Herpesvirus vectors for therapy of brain tumors.

  The open virology journal 20100101

• Coordination of glioblastoma cell motility by PKCι.

  Molecular cancer 20100101

• Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial.

  BMC cancer 20100101

• Determining and interpreting correlations in lipidomic networks found in glioblastoma cells.

  BMC systems biology 20100101

• An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients.

  Molecular cancer 20100101

• Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues.

  Cancer cell international 20100101

• The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma.

  Nutrition & metabolism 20100101

• The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas.

  PloS one 20100101

• The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas.

  BMC cancer 20100101

• Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability.

  PloS one 20100101

• Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma.

  PloS one 20100101

• Temozolomide in malignant glioma.

  OncoTargets and therapy 20100101

• Hemorrhagic cystitis: A challenge to the urologist.

  Indian journal of urology : IJU : journal of the Urological Society of India 20100101

• Standard therapy for glioblastoma--a review of where we are.

  Neurologia medico-chirurgica 20100101

• Bilateral posterior RION after concomitant radiochemotherapy with temozolomide in a patient with glioblastoma multiforme: a case report.

  BMC cancer 20100101

• A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv 'Click Chemistry' targeted to αvβ3 integrin for therapy.

  International journal of medical sciences 20100101

• Chemotherapy in Ewing's sarcoma.

  Indian journal of orthopaedics 20100101

• A comparison of ARMS and DNA sequencing for mutation analysis in clinical biopsy samples.

  Journal of experimental & clinical cancer research : CR 20100101

• Randomised phase I/II study to evaluate carbon ion radiotherapy versus fractionated stereotactic radiotherapy in patients with recurrent or progressive gliomas: the CINDERELLA trial.

  BMC cancer 20100101

• Nano to micro delivery systems: targeting angiogenesis in brain tumors.

  Journal of angiogenesis research 20100101

• Unexpected high response rate to traditional therapy after dendritic cell-based vaccine in advanced melanoma: update of clinical outcome and subgroup analysis.

  Clinical & developmental immunology 20100101

• Development of a Novel Fluorescence Assay Based on the Use of the Thrombin-Binding Aptamer for the Detection of O-Alkylguanine-DNA Alkyltransferase Activity.

  Journal of nucleic acids 20100101

• FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors.

  Molecular cancer 20100101

• Cellular and vaccine therapeutic approaches for gliomas.

  Journal of translational medicine 20100101

• PARP inhibitors in BRCA1/BRCA2 germline mutation carriers with ovarian and breast cancer.

  F1000 biology reports 20100101

• Overview of cellular immunotherapy for patients with glioblastoma.

  Clinical & developmental immunology 20100101

• Targeting the osteosarcoma cancer stem cell.

  Journal of orthopaedic surgery and research 20100101

• Treatment options for patients with triple-negative breast cancer.

  Journal of hematology & oncology 20100101

• Expression of O-Alkylguanine-DNA Alkyltransferase in Normal and Malignant Bladder Tissue of Egyptian Patients.

  Journal of nucleic acids 20100101

• Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepilone.

  Breast cancer research : BCR 20100101

• HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression.

  BMC cancer 20100101

• Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc.

  BMC cancer 20100101

• Temozolomide-induced shrinkage of a pituitary carcinoma causing Cushing's disease--report of a case and literature review.

  TheScientificWorldJournal 20100101

• External irradiation models for intracranial 9L glioma studies.

  Journal of experimental & clinical cancer research : CR 20100101

• Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype.

  PloS one 20100101

• Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: the MARCIE trial.

  BMC cancer 20100101

• Conversion of a molecular classifier obtained by gene expression profiling into a classifier based on real-time PCR: a prognosis predictor for gliomas.

  BMC medical genomics 20100101

• Comparative expression pattern of Matrix-Metalloproteinases in human glioblastoma cell-lines and primary cultures.

  BMC research notes 20100101

• High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study.

  Journal of translational medicine 20100101

• Neck dissection and post-operative chemotherapy with dimethyl triazeno imidazole carboxamide and cisplatin protocol are useful for oral mucosal melanoma.

  BMC cancer 20100101

• The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation.

  Radiation oncology (London, England) 20100101

• Patient-oriented gene set analysis for cancer mutation data.

  Genome biology 20100101

• DNA damage induced by alkylating agents and repair pathways.

  Journal of nucleic acids 20100101

• Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation.

  PloS one 20100101

• DNA methylation in glioblastoma: impact on gene expression and clinical outcome.

  BMC genomics 20100101

• GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma.

  European journal of medical research 20100101

• Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB.

  PloS one 20100101

• c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.

  Molecular cancer 20100101

• Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003--a single institution's experience.

  Radiation oncology (London, England) 20100101

• Role of bevacizumab therapy in the management of glioblastoma.

  Cancer management and research 20100101

• Treatment of cutaneous melanoma: current approaches and future prospects.

  Cancer management and research 20100101

• Epigenomics in cancer management.

  Cancer management and research 20100101

• Anaplastic pleomorphic xanthoastrocytoma with a component of anaplastic astrocytoma presenting as skull base tumor followed by downward extracranial extension. Case report.

  Neurologia medico-chirurgica 20100101

• A phase II trial of sorafenib in metastatic melanoma with tissue correlates.

  PloS one 20100101

• Youngest case of third ventricular anaplastic neurocytoma.

  Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology 20100101

• An unusual case of aplastic anemia caused by temozolomide.

  Case reports in medicine 20100101

• Arsenic trioxide sensitizes cancer stem cells to chemoradiotherapy. A new approach in the treatment of inoperable glioblastoma multiforme.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20100101

• Establishment of prognostic models for astrocytic and oligodendroglial brain tumors with standardized quantification of marker gene expression and clinical variables.

  Biomarker insights 20100101

• UK Guidelines for the Management of Bone Sarcomas.

  Sarcoma 20100101

• Treatment of glioblastoma in elderly patients: an overview of current treatments and future perspective.

  Tumori 20100101

• Chemopotentiation by ultrafractionated radiotherapy in glioblastoma resistant to conventional therapy.

  Tumori 20100101

• [New therapeutic options in therapy of glioblastoma multiforme].

  Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20100101

• Impact of the DNA methyltransferases expression on the methylation status of apoptosis-associated genes in glioblastoma multiforme.

  Cell death & disease 20100101

• Immunotherapy of brain cancers: the past, the present, and future directions.

  Clinical & developmental immunology 20100101

• Treating glioblastoma multiforme with electrical fields.

  World neurosurgery 20100101

• Tardy spinal cord tumor following avulsive brachial plexus injury: coincidental or causal?

  World neurosurgery 20100101

• Supratentorial glioblastoma multiforme with spinal metastases.

  Journal of craniovertebral junction & spine 20100101

• Alterations in gene expression profiles correlated with cisplatin cytotoxicity in the glioma U343 cell line.

  Genetics and molecular biology 20100101

• Advances in the treatment of gastroenteropancreatic neuroendocrine tumors.

  Clinical and experimental gastroenterology 20100101

• Hybrid micro-/nanogels for optical sensing and intracellular imaging.

  Nano reviews 20100101

• The role of funding and policies on innovation in cancer drug development.

  Ecancermedicalscience 20100101

• High-quality genomic DNA extraction from formalin-fixed and paraffin-embedded samples deparaffinized using mineral oil.

  Analytical biochemistry 20091215

• Alveolar rhabdomyosarcoma of the extremity and nodal metastasis: Is the in-transit lymphatic system at risk?

  Pediatric blood & cancer 20091215

• Primary leptomeningeal anaplastic oligodendroglioma with a 1p36-19q13 deletion: report of a unique case successfully treated with Temozolomide.

  Journal of the neurological sciences 20091215

• Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma.

  British journal of cancer 20091215

• Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.

  British journal of cancer 20091215

• Anaplastic glioma: how to prognosticate outcome and choose a treatment strategy. [corrected].

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210

• MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210

• NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210

• Risk analysis of severe myelotoxicity with temozolomide: the effects of clinical and genetic factors.

  Neuro-oncology 20091201

• Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro.

  Neuro-oncology 20091201

• Combined multiple surgical intervention and chemotherapy for multicentric WHO grade II glioma : a long-term follow-up study.

  Acta neurochirurgica 20091201

• Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors.

  Cancer chemotherapy and pharmacology 20091201

• Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells.

  Journal of neuro-oncology 20091201

• Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy.

  Journal of neuro-oncology 20091201

• Neurological outcome of long-term glioblastoma survivors.

  Journal of neuro-oncology 20091201

• Irinotecan and temozolomide for Ewing sarcoma: the Memorial Sloan-Kettering experience.

  Pediatric blood & cancer 20091201

• High-grade glioma mouse models and their applicability for preclinical testing.

  Cancer treatment reviews 20091201

• Classification and management of anaplastic gliomas.

  Current opinion in neurology 20091201

• Treatment of recurrent high-grade gliomas.

  Current opinion in neurology 20091201

• Combining drugs and radiotherapy: from the bench to the bedside.

  Current opinion in neurology 20091201

• Pseudoprogression and pseudoresponse in the treatment of gliomas.

  Current opinion in neurology 20091201

• Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091201

• A novel use of temozolomide in a patient with malignant prolactinoma.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20091201

• Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent.

  International journal of radiation oncology, biology, physics 20091201

• Celastrol synergistically enhances temozolomide cytotoxicity in melanoma cells.

  Molecular cancer research : MCR 20091201

• ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20091201

• Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase.

  Molecular cancer therapeutics 20091201

• A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.

  Molecular cancer research : MCR 20091201

• Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents.

  Anticancer research 20091201

• Neoplastic meningitis from breast cancer: feasibility and activity of long-term intrathecal liposomal Ara-C combined with dose-dense temozolomide.

  Anticancer research 20091201

• Therapeutic windows.

  Molecular interventions 20091201

• Redox-related antimelanoma activity of ATN-224.

  Melanoma research 20091201

• IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide.

  Neurology 20091124

• Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study.

  British journal of cancer 20091117

• Bevacizumab for recurrent ependymoma.

  Neurology 20091117

• Antiangiogenesis in recurrent glioblastoma: proof of principle.

  Neurology international 20091116

• Results of a multicenter, randomized, double-blind, dose-evaluating phase 2/3 study of lenalidomide in the treatment of metastatic malignant melanoma.

  Cancer 20091115

• The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20091115

• Current data and strategy in glioblastoma multiforme.

  Journal of medicine and life 20091115

• Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.

  Journal of medicinal chemistry 20091112

• Primary malignant melanoma of the vagina.

  Archives of gynecology and obstetrics 20091101

• Preoperative intensity-modulated radiotherapy combined with temozolomide for locally advanced soft-tissue sarcoma.

  International journal of radiation oncology, biology, physics 20091101

• Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition.

  Cancer chemotherapy and pharmacology 20091101

• Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience.

  Journal of neuro-oncology 20091101

• Screening of anti-glioma effects induced by sigma-1 receptor ligands: potential new use for old anti-psychiatric medicines.

  European journal of cancer (Oxford, England : 1990) 20091101

• Efficacy of temozolomide as adjuvant chemotherapy after postsurgical radiotherapy alone for glioblastomas.

  Clinical neurology and neurosurgery 20091101

• Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.

  Bioorganic & medicinal chemistry 20091101

• New advances that enable identification of glioblastoma recurrence.

  Nature reviews. Clinical oncology 20091101

• The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas.

  Neurosurgery 20091101

• Prognostic significance of molecular markers and extent of resection in primary glioblastoma patients.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20091101

• Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repair.

  Nuclear medicine and biology 20091101

• Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme.

  Expert review of anticancer therapy 20091101

• FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme.

  The oncologist 20091101

• The importance of tumor volume in the prognosis of patients with glioblastoma: comparison of computerized volumetry and geometric models.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20091101

• Glioblastoma multiforme associated with klinefelter syndrome.

  Neurologia medico-chirurgica 20091101

• Anti-glioma therapy with temozolomide and status of the DNA-repair gene MGMT.

  Anticancer research 20091101

• Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development.

  Biochemistry 20091027

• NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma.

  British journal of cancer 20091020

• Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling.

  Cancer letters 20091018

• Temozolomide for recurrent intracranial supratentorial platinum-refractory ependymoma.

  Cancer 20091015

• Enhancement of cancer chemotherapy by simultaneously altering cell cycle progression and DNA-damage defenses through global modification of the serine/threonine phospho-proteome.

  Cell cycle (Georgetown, Tex.) 20091015

• Design and modification of EGF4KDEL 7Mut, a novel bispecific ligand-directed toxin, with decreased immunogenicity and potent anti-mesothelioma activity.

  British journal of cancer 20091006

• DNA ligase IV as a new molecular target for temozolomide.

  Biochemical and biophysical research communications 20091002

• Pseudoprogression after radiotherapy with concurrent temozolomide for high-grade glioma: clinical observations and working recommendations.

  Surgical neurology 20091001

• Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model.

  Cancer immunology, immunotherapy : CII 20091001

• Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.

  Neuro-oncology 20091001

• CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma.

  Cancer gene therapy 20091001

• Early metabolic responses in temozolomide treated low-grade glioma patients.

  Journal of neuro-oncology 20091001

• Glioma-associated endothelial cells are chemoresistant to temozolomide.

  Journal of neuro-oncology 20091001

• Non-Hodgkin lymphoma following temozolomide.

  Pediatric blood & cancer 20091001

• The prognostic role of Beclin 1 protein expression in high-grade gliomas.

  Autophagy 20091001

• Management of glioblastoma multiforme in HIV patients: a case series and review of published studies.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20091001

• High incidence of low O(6)-methylguanine DNA methyltransferase expression in invasive macroadenomas of Cushing's disease.

  European journal of endocrinology 20091001

• A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.

  Cancer chemotherapy and pharmacology 20091001

• Clinical outcome of concomitant chemoradiotherapy followed by adjuvant temozolomide therapy for glioblastaomas: single-center experience.

  Clinical neurology and neurosurgery 20091001

• The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.

  Molecular pharmacology 20091001

• Temozolomide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy.

  European journal of endocrinology 20091001

• Insights into pharmacotherapy of malignant glioma in adults.

  Expert opinion on pharmacotherapy 20091001

• Neurological adverse effects caused by cytotoxic and targeted therapies.

  Nature reviews. Clinical oncology 20091001

• Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumors.

  Oncology reports 20091001

• Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model.

  Cancer biology & therapy 20091001

• Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians.

  Pharmacogenetics and genomics 20091001

• Rituximab maintenance therapy in central nervous system lymphoma?

  Leukemia & lymphoma 20091001

• Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.

  Radiation research 20091001

• Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?

  Clinical cancer research : an official journal of the American Association for Cancer Research 20091001

• Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways.

  Molecular cancer research : MCR 20091001

• Supratentorial, extraventricular choroid plexus carcinoma in an adult: case report.

  Neurosurgery 20091001

• p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor.

  Anticancer research 20091001

• Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis.

  Anticancer research 20091001

• A phase II study of cisplatin and temozolomide in heavily pre-treated patients with temozolomide-refractory high-grade malignant glioma.

  Anticancer research 20091001

• [Medical management of primary central nervous system lymphoma refractory or resistant to standard of care treatment].

  Brain and nerve = Shinkei kenkyu no shinpo 20091001

• Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas.

  British journal of cancer 20090915

• Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).

  Cancer chemotherapy and pharmacology 20090901

• The sodium pump alpha1 sub-unit: a disease progression-related target for metastatic melanoma treatment.

  Journal of cellular and molecular medicine 20090901

• Carbonate and carbamate derivatives of 4-demethylpenclomedine as novel anticancer agents.

  Cancer chemotherapy and pharmacology 20090901

• Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy.

  Journal of cancer research and clinical oncology 20090901

• Primary leptomeningeal oligodendrogliomatosis.

  Journal of neuro-oncology 20090901

• Use of FDA approved methamphetamine to allow adjunctive use of methylnaltrexone to mediate core anti-growth factor signaling effects in glioblastoma.

  Journal of neuro-oncology 20090901

• Disseminated strongyloidiasis complicating glioblastoma therapy: a case report.

  Journal of neuro-oncology 20090901

• Delivery of temozolomide to the tumor bed via biodegradable gel matrices in a novel model of intracranial glioma with resection.

  Journal of neuro-oncology 20090901

• Cytomegalovirus associated colonic pseudotumor: a consequence of iatrogenic immunosuppression in a patient with primary brain tumor receiving radiation and temozolomide.

  Journal of neuro-oncology 20090901

• Combined radio- and chemotherapy of brain tumours in adult patients.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20090901

• Clinical utility of temozolomide in the treatment of malignant paraganglioma: a preliminary report.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090901

• Combined modality treatment of newly diagnosed glioblastoma multiforme in a regional neurosurgical centre.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090901

• Temozolomide in malignant gliomas: current use and future targets.

  Cancer chemotherapy and pharmacology 20090901

• Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090901

• In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma.

  European journal of cancer (Oxford, England : 1990) 20090901

• A rare case of aplastic anemia caused by temozolomide.

  Southern medical journal 20090901

• Treatment of malignant pheochromocytoma.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090901

• Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.

  International journal of radiation oncology, biology, physics 20090901

• Glioblastoma masquerading as a hypertensive putaminal hemorrhage: a diagnostic pitfall.

  Neurologia medico-chirurgica 20090901

• Population-based study of pseudoprogression after chemoradiotherapy in GBM.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20090901

• Recurrent PNET with MGMT methylation responds to temozolomide.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20090901

• [Pituitary carcinomas and aggressive adenomas: an overview and new therapeutic options].

  Annales d'endocrinologie 20090901

• Six year survival after prolonged temozolomide treatment in a 30-year-old patient with glioblastoma.

  Acta neurologica Belgica 20090901

• Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model.

  Cancer letters 20090818

• Two phase II trials of temozolomide with interferon-alpha2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme.

  British journal of cancer 20090818

• Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090810

• Societal preference values for advanced melanoma health states in the United Kingdom and Australia.

  British journal of cancer 20090804

• MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea.

  British journal of cancer 20090804

• [A multicenter randomized controlled study of temozolomide in 97 patients with malignant brain glioma].

  Zhonghua yi xue za zhi 20090804

• Low O6-methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours.

  Clinical endocrinology 20090801

• Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology?

  Journal of neuro-oncology 20090801

• Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy. Laboratory investigation.

  Journal of neurosurgery 20090801

• Cisplatinum and BCNU chemotherapy in primary glioblastoma patients.

  Journal of neuro-oncology 20090801

• Effect of adding temozolomide to radiation therapy on the incidence of pseudo-progression.

  Journal of neuro-oncology 20090801

• Pseudoprogression in boron neutron capture therapy for malignant gliomas and meningiomas.

  Neuro-oncology 20090801

• Low-grade gliomas.

  Current treatment options in oncology 20090801

• The role of chemotherapy for pure and mixed anaplastic oligodendroglial tumors.

  Current treatment options in oncology 20090801

• IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era.

  International journal of cancer 20090801

• Cancer cell death by design: apoptosis, autophagy and glioma virotherapy.

  Autophagy 20090801

• A phase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma.

  Cancer investigation 20090801

• Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy.

  Cancer 20090801

• Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status.

  Cancer 20090801

• Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine.

  Melanoma research 20090801

• Small molecules and targeted therapies in distant metastatic disease.

  Annals of oncology : official journal of the European Society for Medical Oncology 20090801

• Immunotherapy of distant metastatic disease.

  Annals of oncology : official journal of the European Society for Medical Oncology 20090801

• Comment re: Temozolomide preferentially depletes cancer stem cells.

  Cancer research 20090801

• Prolonged cell cycle response of HeLa cells to low-level alkylation exposure.

  Cancer research 20090801

• Diagnosis and management of leptomeningeal disease.

  Clinical journal of oncology nursing 20090801

• Hypersensitivity pneumonitis associated with temozolomide.

  The European respiratory journal 20090801

• Perioperative high-dose-rate brachytherapy in the treatment of recurrent malignant gliomas.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20090801

• Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines.

  Anticancer research 20090801

• First experiences with low-dose anti-angiogenic treatment in gliomatosis cerebri with signs of angiogenic activity.

  Anticancer research 20090801

• Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.

  Molecular cancer therapeutics 20090801

• [Recent trends in the pathophysiology and treatment of pituitary adenomas].

  Brain and nerve = Shinkei kenkyu no shinpo 20090801

• Radiotherapy for metastatic brain tumors.

  International journal of clinical oncology 20090801

• Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines.

  British journal of cancer 20090721

• MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090715

• Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy.

  British journal of cancer 20090707

• High-dose radiotherapy to 78 Gy with or without temozolomide for high grade gliomas.

  Journal of neuro-oncology 20090701

• Imaging biological activity of a glioblastoma treated with an individual patient-tailored, experimental therapy regimen.

  Journal of neuro-oncology 20090701

• Multiple intracranial melanoma metastases: case report and review of the literature.

  Journal of neuro-oncology 20090701

• Cerebral astroblastoma: analysis of six cases and critical review of treatment options.

  Journal of neuro-oncology 20090701

• Interferon-beta, MCNU, and conventional radiotherapy for pediatric patients with brainstem glioma.

  Pediatric blood & cancer 20090701

• Initial clinical experience with frameless optically guided stereotactic radiosurgery/radiotherapy in pediatric patients.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20090701

• Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.

  Cancer 20090701

• The safety of temozolomide in the treatment of malignancies.

  Expert opinion on drug safety 20090701

• New insights into the hemangiopericytoma/solitary fibrous tumor spectrum of tumors.

  Current opinion in oncology 20090701

• Functional and metabolic magnetic resonance imaging and positron emission tomography for tumor volume definition in high-grade gliomas.

  Seminars in radiation oncology 20090701

• In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.

  The Journal of clinical investigation 20090701

• Effect of IFN-beta on human glioma cell lines with temozolomide resistance.

  International journal of oncology 20090701

• Glioblastoma multiforme.

  Current treatment options in neurology 20090701

• Treatment of spinal cord tumors.

  Current treatment options in neurology 20090701

• Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells.

  Molecular cancer therapeutics 20090701

• FEN1 is overexpressed in testis, lung and brain tumors.

  Anticancer research 20090701

• Pseudoprogression and MGMT status in glioblastoma patients: implications in clinical practice.

  Anticancer research 20090701

• [Clinicopathological diagnosis of gliomas by genotype analysis].

  Brain and nerve = Shinkei kenkyu no shinpo 20090701

• [Treatment of glioma with temozolomide].

  Brain and nerve = Shinkei kenkyu no shinpo 20090701

• Glioblastoma stem cells resistant to temozolomide-induced autophagy.

  Chinese medical journal 20090605

• Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro.

  Chinese medical journal 20090605

• [Atypical pseudotumoral neuromeningeal cryptococcosis in an immunocompromised patient treated for pontine glioma. Case report and literature review].

  Neuro-Chirurgie 20090601

• Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts.

  Neuro-oncology 20090601

• Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model.

  Neuro-oncology 20090601

• Phase I study of the combination of docetaxel, temozolomide and cisplatin in patients with metastatic melanoma.

  Cancer chemotherapy and pharmacology 20090601

• Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.

  The Journal of investigative dermatology 20090601

• Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies.

  International journal of radiation oncology, biology, physics 20090601

• Extended exposure to alkylator chemotherapy: delayed appearance of myelodysplasia.

  Journal of neuro-oncology 20090601

• Disposition of temozolomide in a patient with glioblastoma multiforme after gastric bypass surgery.

  Journal of neuro-oncology 20090601

• Anti-proliferative effect of the gastrin-release peptide receptor antagonist RC-3095 plus temozolomide in experimental glioblastoma models.

  Journal of neuro-oncology 20090601

• Radiological progression of cerebral metastases after radiosurgery: assessment of perfusion MRI for differentiating between necrosis and recurrence.

  Journal of neurology 20090601

• Long-term use of temozolomide: could you use temozolomide safely for life in gliomas?

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090601

• Concurrent radiotherapy: fotemustine combination for newly diagnosed malignant glioma patients, a phase II study.

  Cancer chemotherapy and pharmacology 20090601

• p15 promoter methylation - a novel prognostic marker in glioblastoma patients.

  International journal of oncology 20090601

• Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma.

  Melanoma research 20090601

• The history and future of chemotherapy for melanoma.

  Hematology/oncology clinics of North America 20090601

• Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.

  Molecular cancer research : MCR 20090601

• Novel therapeutics for melanoma.

  Expert review of anticancer therapy 20090601

• Cost-effectiveness of temozolomide for the treatment of newly diagnosed glioblastoma multiforme.

  Expert review of pharmacoeconomics & outcomes research 20090601

• A network of conserved damage survival pathways revealed by a genomic RNAi screen.

  PLoS genetics 20090601

• Spinal cord oligodendroglioma with 1p and 19q deletions presenting with cerebral oligodendrogliomatosis.

  Journal of neurosurgery. Spine 20090601

• Cell cycle effects and increased adduct formation by temozolomide enhance the effect of cytotoxic and targeted agents in lung cancer cell lines.

  Journal of chemotherapy (Florence, Italy) 20090601

• [Central nervous system glioma. Multi-drug chemotherapy including temozolomide].

  Gan to kagaku ryoho. Cancer & chemotherapy 20090601

• [Detection of O6-methylguanine-DNA methyltransferase promoter methylation in chemotherapy for glioma].

  Ai zheng = Aizheng = Chinese journal of cancer 20090601

• Mapping the literature: role of trabectedin as a new chemotherapy option in advanced pretreated soft tissue sarcoma.

  Drugs of today (Barcelona, Spain : 1998) 20090601

• Cerebellar glioblastoma in the elderly--case report.

  Acta clinica Croatica 20090601

• Molecular markers of tumor progression in melanoma.

  Current genomics 20090601

• The outcomes of concomitant radiation plus temozolomide followed by adjuvant temozolomide for newly diagnosed high grade gliomas: the preliminary results of single center prospective study.

  Journal of the Egyptian National Cancer Institute 20090601

• Dose escalation methods in phase I cancer clinical trials.

  Journal of the National Cancer Institute 20090520

• Molecular classification of solid tumours: towards pathway-driven therapeutics.

  British journal of cancer 20090519

• The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2.

  Biochemical pharmacology 20090515

• EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma.

  Cancer research 20090515

• Folate supplementation limits the aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and proliferation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090515

• Bevacizumab and irinotecan for recurrent oligodendroglial tumors.

  Neurology 20090505

• Efficacy of temozolomide for recurrent embryonal brain tumors in children.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20090501

• Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: tumour progression or radionecrosis?

  Clinical neurology and neurosurgery 20090501

• Rechallenge with temozolomide in patients with recurrent gliomas.

  Journal of neurology 20090501

• Occipital ganglio-neuroblastoma in an adult.

  Acta neurochirurgica 20090501

• Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.

  The Lancet. Oncology 20090501

• The combination topotecan, temozolomide and dexamethasone associated with radiotherapy as treatment of central nervous system myeloma relapse.

  International journal of hematology 20090501

• Progress in the treatment of neuroendocrine tumors.

  Current oncology reports 20090501

• Antifolate activity of pyrimethamine enhances temozolomide-induced cytotoxicity in melanoma cells.

  Molecular cancer research : MCR 20090501

• Treatment options for recurrent glioblastoma: pitfalls and future trends.

  Expert review of anticancer therapy 20090501

• [Prescription guidebook for temozolomide usage in brain tumors].

  Bulletin du cancer 20090501

• Structural adaptation and heterogeneity of normal and tumor microvascular networks.

  PLoS computational biology 20090501

• Methodological approaches in application of synthetic lethality screening towards anticancer therapy.

  British journal of cancer 20090421

• A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma.

  British journal of cancer 20090421

• O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib.

  British journal of cancer 20090421

• Temozolomide with radiation therapy in high grade brain gliomas: pharmaceuticals considerations and efficacy; a review article.

  Molecules (Basel, Switzerland) 20090416

• Bevacizumab for recurrent alkylator-refractory anaplastic oligodendroglioma.

  Cancer 20090415

• Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo.

  British journal of cancer 20090407

• RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs.

  Brain pathology (Zurich, Switzerland) 20090401

• Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells.

  Neuro-oncology 20090401

• Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131.

  Neuro-oncology 20090401

• Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases.

  Neuro-oncology 20090401

• Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma--analysis of O6-methylguanine-DNA methyltransferase status.

  Journal of neuro-oncology 20090401

• Possible leukemogenic potential of temozolomide.

  Pediatric blood & cancer 20090401

• Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.

  NeuroImage 20090401

• Opportunistic cytomegalovirus infection in a patient receiving temozolomide for treatment of malignant glioma.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090401

• NHERF-1: modulator of glioblastoma cell migration and invasion.

  Neoplasia (New York, N.Y.) 20090401

• Hypersensitivity pneumonitis associated with the use of temozolomide.

  The European respiratory journal 20090401

• BNIP3 (Bcl-2 19 kDa interacting protein) acts as transcriptional repressor of apoptosis-inducing factor expression preventing cell death in human malignant gliomas.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401

• Use of temozolomide in aggressive pituitary tumors: case report.

  Neurosurgery 20090401

• [Prognostic and predictive factors for gliomas in adults].

  Bulletin du cancer 20090401

• Synchronous tonsil, gallbladder, and cardiac metastases without any other visceral metastases of malignant melanoma.

  Onkologie 20090401

• Recent clinical and pathophysiological advances in non-functioning pituitary adenomas.

  Hormone research 20090401

• Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies.

  British journal of cancer 20090324

• Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090315

• Phase I trial of oral irinotecan and temozolomide for children with relapsed high-risk neuroblastoma: a new approach to neuroblastoma therapy consortium study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090310

• Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma: correlation With MGMT promoter methylation status.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090310

• Long-term survival of patients with glioblastoma treated with radiotherapy and lomustine plus temozolomide.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090310

• Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090310

• Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090310

• Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo.

  British journal of cancer 20090310

• The side story of stem-like glioma cells.

  Cell stem cell 20090306

• PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.

  Cell stem cell 20090306

• Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways.

  Purinergic signalling 20090301

• Association of preoperative depression and survival after resection of malignant brain astrocytoma.

  Surgical neurology 20090301

• Tuberculosis in a patient on temozolomide: a case report.

  Journal of neuro-oncology 20090301

• ACNU-based chemotherapy for recurrent glioma in the temozolomide era.

  Journal of neuro-oncology 20090301

• Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model.

  Journal of neuro-oncology 20090301

• Temozolomide single-agent chemotherapy for newly diagnosed anaplastic oligodendroglioma.

  Journal of neuro-oncology 20090301

• A multi-institutional phase II study on second-line Fotemustine chemotherapy in recurrent glioblastoma.

  Journal of neuro-oncology 20090301

• Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme.

  Journal of neurosurgery 20090301

• Exophytic giant cell glioblastoma of the medulla oblongata.

  Journal of neurosurgery 20090301

• Association between hyperglycemia and survival in patients with newly diagnosed glioblastoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090301

• O(6)-methylguanine DNA methyltransferase immunoexpression in nonfunctioning pituitary adenomas: are progressive tumors potential candidates for temozolomide treatment?

  Cancer 20090301

• Differential effect of imatinib and synergism of combination treatment with chemotherapeutic agents in malignant glioma cells.

  Basic & clinical pharmacology & toxicology 20090301

• Inverse-electron-demand Diels-Alder reaction as a highly efficient chemoselective ligation procedure: synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells.

  Journal of peptide science : an official publication of the European Peptide Society 20090301

• Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells.

  Cancer research 20090301

• [Evaluation of stability of temozolomide in solutions after opening the capsule].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090301

• Management of temozolomide toxicity by nurse practitioners in neuro-oncology.

  Oncology nursing forum 20090301

• Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy.

  Molecular cancer therapeutics 20090301

• Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide.

  Cancer biology & therapy 20090301

• [Bilateral thalamic glioma in an adult: a case report and review of the literature].

  No shinkei geka. Neurological surgery 20090301

• [Association of radiotherapy and chemotherapy-targeted therapies in glioblastomas].

  Bulletin du cancer 20090301

• [Biological basis of chemo-radiotherapy associations].

  Bulletin du cancer 20090301

• [Predictive molecular pathological testing in the diagnosis of high-grade tumors of glial origin].

  Magyar onkologia 20090301

• [Research and therapeutic trials on gliomas].

  Soins; la revue de reference infirmiere 20090301

• Efficacy of temozolomide treatment in patients with high-grade glioma.

  Anticancer research 20090301

• Primary CNS lymphoma.

  Therapeutic advances in neurological disorders 20090301

• The context and potential of epigenetics in oncology.

  British journal of cancer 20090224

• Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090215

• Integrating BRAF/MEK inhibitors into combination therapy for melanoma.

  British journal of cancer 20090210

• Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells.

  Biochemical and biophysical research communications 20090206

• Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture.

  Investigational new drugs 20090201

• Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis.

  International journal of radiation oncology, biology, physics 20090201

• Topotecan enhances immune clearance of gliomas.

  Cancer immunology, immunotherapy : CII 20090201

• Quality of life in low-grade glioma patients receiving temozolomide.

  Neuro-oncology 20090201

• New (alternative) temozolomide regimens for the treatment of glioma.

  Neuro-oncology 20090201

• Experience with irinotecan for the treatment of malignant glioma.

  Neuro-oncology 20090201

• The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.

  Neuro-oncology 20090201

• Association of 11C-methionine PET uptake with site of failure after concurrent temozolomide and radiation for primary glioblastoma multiforme.

  International journal of radiation oncology, biology, physics 20090201

• Concomitant (without adjuvant) temozolomide and radiation to treat glioblastoma: a retrospective study.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20090201

• Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090201

• A color-coded orthotopic nude-mouse treatment model of brain-metastatic paralyzing spinal cord cancer that induces angiogenesis and neurogenesis.

  Cell proliferation 20090201

• Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines.

  Molecular cancer therapeutics 20090201

• Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma.

  Cell cycle (Georgetown, Tex.) 20090201

• Oligodendrogliomas: molecular biology and treatment.

  The oncologist 20090201

• Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090201

• Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma.

  Molecular cancer therapeutics 20090201

• Editorial: on the road to multi-modal and pluri-disciplinary treatment of glioblastomas.

  Acta neurochirurgica 20090201

• p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal.

  Molecular cancer research : MCR 20090201

• Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines.

  International journal of radiation biology 20090201

• Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.

  British journal of cancer 20090127

• A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer.

  British journal of cancer 20090127

• Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.

  Journal of medicinal chemistry 20090122

• [Microsurgical strategies of glioma located in lateral fissure area].

  Zhonghua yi xue za zhi 20090120

• Genomic and molecular profiling predicts response to temozolomide in melanoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090115

• In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090115

• Activation of KATP channels increases anticancer drug delivery to brain tumors and survival.

  European journal of pharmacology 20090114

• Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases.

  Brain pathology (Zurich, Switzerland) 20090101

• A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients.

  Annals of oncology : official journal of the European Society for Medical Oncology 20090101

• Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting alpha 3 integrin.

  European journal of nuclear medicine and molecular imaging 20090101

• Hypofractionated radiotherapy followed by adjuvant chemotherapy with temozolomide in elderly patients with glioblastoma.

  Journal of neuro-oncology 20090101

• Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors.

  Journal of neuro-oncology 20090101

• Comparative analysis of temozolomide (TMZ) versus 1,3-bis (2-chloroethyl)-1 nitrosourea (BCNU) in newly diagnosed glioblastoma multiforme (GBM) patients.

  Journal of neuro-oncology 20090101

• Bone marrow transplantation for severe aplastic anemia secondary to temozolomide.

  Journal of neuro-oncology 20090101

• Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.

  DNA repair 20090101

• Cryopreservation of neurospheres derived from human glioblastoma multiforme.

  Stem cells (Dayton, Ohio) 20090101

• Independent association of extent of resection with survival in patients with malignant brain astrocytoma.

  Journal of neurosurgery 20090101

• MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma.

  European journal of cancer (Oxford, England : 1990) 20090101

• Absence of MGMT promoter methylation in endometrial cancer.

  Gynecologic oncology 20090101

• Treatment of Nelson's syndrome with temozolomide.

  European journal of endocrinology 20090101

• Management of aggressive pituitary adenomas: current treatment strategies.

  Pituitary 20090101

• Genetically engineered mouse models of brain cancer and the promise of preclinical testing.

  Brain pathology (Zurich, Switzerland) 20090101

• [Diagnostic and treatment delays do not modify the treatment outcome of patients with multiform glioblastoma].

  Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20090101

• A new model for prediction of drug distribution in tumor and normal tissues: pharmacokinetics of temozolomide in glioma patients.

  Cancer research 20090101

• Phase II study of protracted daily temozolomide for low-grade gliomas in adults.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090101

• O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090101

• Whole brain radiotherapy with radiosensitizer for brain metastases.

  Journal of experimental & clinical cancer research : CR 20090101

• Chemotherapeutic treatment efficacy and sensitivity are increased by adjuvant alternating electric fields (TTFields).

  BMC medical physics 20090101

• Continuous administration of daily low-dose temozolomide in pretreated patients with advanced non-small cell lung cancer: a phase II study.

  Oncology 20090101

• HMGB1 mediates endogenous TLR2 activation and brain tumor regression.

  PLoS medicine 20090101

• Recent approaches to improve the antitumor efficacy of temozolomide.

  Current medicinal chemistry 20090101

• Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells.

  Journal of translational medicine 20090101

• Encountering and advancing through antiangiogenesis therapy for gliomas.

  Current pharmaceutical design 20090101

• Nodular melanoma presenting with rapid progression and widespread metastases: a case report.

  Journal of medical case reports 20090101

• Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation.

  BMC genomics 20090101

• Modulation of the efficacy of temozolomide and dacarbazine melanoma treatment by DNA-repair factors in vivo and in vitro.

  International journal of clinical pharmacology and therapeutics 20090101

• The potential role and application of PARP inhibitors in cancer treatment.

  British medical bulletin 20090101

• Localized BCNU chemotherapy and the multimodal management of malignant glioma.

  Current medical research and opinion 20090101

• The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.

  PloS one 20090101

• Autophagy pathways in glioblastoma.

  Methods in enzymology 20090101

• Nimustine (ACNU) plus teniposide (VM26) in recurrent glioblastoma.

  Oncology 20090101

• Brain metastasis from an unknown primary, or primary brain tumour? A diagnostic dilemma.

  Current oncology (Toronto, Ont.) 20090101

• Multiple pilomatricomas and gliomatosis cerebri--a new association?

  Pediatric dermatology 20090101

• Loss of heterozygosity of TRIM3 in malignant gliomas.

  BMC cancer 20090101

• A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells.

  Journal of neuroinflammation 20090101

• Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors.

  PloS one 20090101

• Stereotactic radiosurgery for glioblastoma: retrospective analysis.

  Radiation oncology (London, England) 20090101

• Radiation therapy.

  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20090101

• Other experimental therapies for glioma.

  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20090101

• Molecular neuropathology of gliomas.

  International journal of molecular sciences 20090101

• Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation.

  BMC cancer 20090101

• Current concepts and newer developments in the treatment of malignant gliomas.

  Indian journal of cancer 20090101

• Evidence-based adjuvant therapy for gliomas: current concepts and newer developments.

  Indian journal of cancer 20090101

• PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.

  PloS one 20090101

• ACTH-producing carcinoma of the pituitary with refractory Cushing's Disease and hepatic metastases: a case report and review of the literature.

  World journal of surgical oncology 20090101

• Effects of fotemustine or dacarbasine on a melanoma cell line pretreated with therapeutic proton irradiation.

  Journal of experimental & clinical cancer research : CR 20090101

• Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.

  PloS one 20090101

• Present and potential future adjuvant issues in high-grade astrocytic glioma treatment.

  Advances and technical standards in neurosurgery 20090101

• Breast cancer therapy for BRCA1 carriers: moving towards platinum standard?

  Hereditary cancer in clinical practice 20090101

• Current concepts in stereotactic radiosurgery - a neurosurgical and radiooncological point of view.

  European journal of medical research 20090101

• Preradiation chemotherapy with ACNU-CDDP in patients with newly diagnosed glioblastoma: a retrospective analysis.

  Chemotherapy 20090101

• Primary diffuse leptomeningeal gliomatosis.

  European neurology 20090101

• The role side effects play in the choice of antiepileptic therapy in brain tumor-related epilepsy: a comparative study on traditional antiepileptic drugs versus oxcarbazepine.

  Journal of experimental & clinical cancer research : CR 20090101

• Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies.

  PloS one 20090101

• CTLA4 blockade increases Th17 cells in patients with metastatic melanoma.

  Journal of translational medicine 20090101

• Management of malignant melanoma: best practices.

  Journal of cutaneous medicine and surgery 20090101

• Temozolomide and cisplatin in relapsed/refractory acute leukemia.

  Journal of hematology & oncology 20090101

• Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

  PloS one 20090101

• Stevens-Johnson Syndrome and toxic epidermal necrolysis overlap due to oral temozolomide and cranial radiotherapy.

  American journal of clinical dermatology 20090101

• High specificity of quantitative methylation-specific PCR analysis for MGMT promoter hypermethylation detection in gliomas.

  Journal of biomedicine & biotechnology 20090101

• Temozolomide: a safe and effective treatment for malignant digestive endocrine tumors.

  Neuroendocrinology 20090101

• Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment.

  PloS one 20090101

• Modulation of angiogenic and inflammatory response in glioblastoma by hypoxia.

  PloS one 20090101

• KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?

  BMC cancer 20090101

• Outcome of newly diagnosed glioblastoma patients treated by radiotherapy plus concomitant and adjuvant temozolomide: a long-term analysis.

  Tumori 20090101

• Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations.

  Journal of translational medicine 20090101

• Retrospective analysis of treatment outcome in 315 patients with oligodendroglial brain tumors.

  BMC neurology 20090101

• Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy.

  PloS one 20090101

• Vorinostat in solid and hematologic malignancies.

  Journal of hematology & oncology 20090101

• Genomic advances and their impact on clinical trial design.

  Genome medicine 20090101

• ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside.

  Journal of hematology & oncology 20090101

• Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma.

  BMC cancer 20090101

• Prognostic factors other than the performance status and age for glioblastoma multiforme: a single-institution experience.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20090101

• Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.

  PloS one 20090101

• MGMT promoter hypermethylation in a series of 104 glioblastomas.

  Cancer genomics & proteomics 20090101

• Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy.

  PloS one 20090101

• Diffuse anorectal melanoma; review of the current diagnostic and treatment aspects based on a case report.

  World journal of surgical oncology 20090101

• Three-dimensional conformal radiotherapy, temozolomide chemotherapy, and high-dose fractionated stereotactic boost in a protocol-driven, postoperative treatment schedule for high-grade gliomas.

  Tumori 20090101

• Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy.

  Molecular cancer 20090101

• Current available therapies and future directions in the treatment of malignant gliomas.

  Biologics : targets & therapy 20090101

• Long-term pegylated interferon-alpha and its potential in the treatment of melanoma.

  Biologics : targets & therapy 20090101

• Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors.

  Journal of translational medicine 20090101

• RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study.

  BMC cancer 20090101

• Transcriptome and proteome analyses of adaptive responses to methyl methanesulfonate in Escherichia coli K-12 and ada mutant strains.

  BMC microbiology 20090101

• Recent advances in systemic therapy. When HER2 is not the target: advances in the treatment of HER2-negative metastatic breast cancer.

  Breast cancer research : BCR 20090101

• Transcriptional control of Flt3 ligand targeted by fluorouracil-induced Egr-1 promoter in hematopoietic damage.

  Journal of biomedical science 20090101

• Current use and potential role of bevacizumab in the treatment of gastrointestinal cancers.

  Biologics : targets & therapy 20090101

• Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells.

  Molecular cancer 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays.

  Genome biology 20090101

• Immunological considerations of modern animal models of malignant primary brain tumors.

  Journal of translational medicine 20090101

• Do neurooncological patients and their significant others agree on quality of life ratings?

  Health and quality of life outcomes 20090101

• Intralesional lymphokine-activated killer cells as adjuvant therapy for primary glioblastoma.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20090101

• GSK3beta regulates differentiation and growth arrest in glioblastoma.

  PloS one 20090101

• Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells.

  Radiation oncology (London, England) 20090101

• Gliomatosis cerebri type II: two case reports.

  Journal of medical case reports 20090101

• Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults.

  BMC cancer 20090101

• Insights into gliomagenesis: systems biology unravels key pathways.

  Genome medicine 20090101

• Therapy-related myelodysplastic syndrome/acute myeloid leukemia after treatment with temozolomide in a patient with glioblastoma multiforme.

  Annals of clinical and laboratory science 20090101

• Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte oncology network.

  BMC cancer 20090101

• Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection.

  PloS one 20090101

• Management of advanced stage uterine sarcomas: a bone of contention.

  European journal of gynaecological oncology 20090101

• Preparation and the influencing factors of timozolomide liposomes.

  Artificial cells, blood substitutes, and immobilization biotechnology 20090101

• yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients.

  Journal of translational medicine 20090101

• Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.

  PloS one 20090101

• Integrated-boost IMRT or 3-D-CRT using FET-PET based auto-contoured target volume delineation for glioblastoma multiforme--a dosimetric comparison.

  Radiation oncology (London, England) 20090101

• Metastatic Melanoma presenting 24 years after surgical resection: a case report and review of the literature.

  Cases journal 20090101

• High-resolution flow cytometry: a suitable tool for monitoring aneuploid prostate cancer cells after TMZ and TMZ-BioShuttle treatment.

  International journal of medical sciences 20090101

• [Glioblastoma treatment in 2010].

  Revue medicale de Bruxelles 20090101

• Introduction of hypermatrix and operator notation into a discrete mathematics simulation model of malignant tumour response to therapeutic schemes in vivo. Some operator properties.

  Cancer informatics 20090101

• Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme.

  BMC cancer 20090101

• Recursive partitioning analysis of prognostic factors in WHO grade III glioma patients treated with radiotherapy or radiotherapy plus chemotherapy.

  BMC cancer 20090101

• Effect of temozolomide in a patient with recurring oncocytic gonadotrophic pituitary adenoma.

  Hormones (Athens, Greece) 20090101

• Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma.

  PloS one 20090101

• Targeted therapy in melanoma.

  Biologics : targets & therapy 20090101

• Antiangiogenic therapy in the treatment of recurrent medulloblastoma in the adult: case report and review of the literature.

  Journal of oncology 20090101

• Potential Role of Thymosin-alpha1 Adjuvant Therapy for Glioblastoma.

  Journal of oncology 20090101

• A small interference RNA screen revealed proteasome inhibition as strategy for glioblastoma therapy.

  Clinical neurosurgery 20090101

• In Silico Enhanced Restriction Enzyme Based Methylation Analysis of the Human Glioblastoma Genome Using Agilent 244K CpG Island Microarrays.

  Frontiers in neuroscience 20090101

• Malignant gastrointestinal melanoma with an unknown primary.

  Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology 20090101

• Role of palliative radiotherapy in brain metastases.

  Indian journal of palliative care 20090101

• Targeted therapy in the treatment of malignant gliomas.

  OncoTargets and therapy 20090101

• Palliative Benefits of the Multimodality Approach in the Re-treatment of Recurrent Malignant Glioma: Two Case Reports.

  Indian journal of palliative care 20090101

• Temozolomide: The evidence for its therapeutic efficacy in malignant astrocytomas.

  Core evidence 20090101

• New therapies for recurrent glioblastomas.

  F1000 medicine reports 20090101

• Treated choroidal melanoma with late metastases to the contralateral orbit.

  Clinical medicine. Pathology 20090101

• Critical appraisal of temozolomide formulations in the treatment of primary brain tumors: patient considerations.

  Cancer management and research 20090101

• Gene therapy in thalassemia and hemoglobinopathies.

  Mediterranean journal of hematology and infectious diseases 20090101

• Salvage therapy with temozolomide for recurrent or progressive high-grade gliomas refractory to ACNU [1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride].

  Molecular medicine reports 20090101

• Current management of metastatic melanoma.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081215

• p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts.

  Cancer research 20081215

• Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081215

• Stemming cancer: functional genomics of cancer stem cells in solid tumors.

  Stem cell reviews 20081201

• Phase I trial of weekly docetaxel and daily temozolomide in patients with metastatic disease.

  Investigational new drugs 20081201

• Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy.

  European journal of radiology 20081201

• A novel tool to analyze MRI recurrence patterns in glioblastoma.

  Neuro-oncology 20081201

• Dose-intensity temozolomide after concurrent chemoradiotherapy in operated high-grade gliomas.

  Journal of neuro-oncology 20081201

• Development of an O(6)-alkylguanine-DNA alkyltransferase assay based on covalent transfer of the benzyl moiety from [benzene-3H]O(6)-benzylguanine to the protein.

  Analytical biochemistry 20081201

• Silencing DNA methyltransferase (DNMT) enhances glioma chemosensitivity.

  Oligonucleotides 20081201

• Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib.

  Nature clinical practice. Oncology 20081201

• Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20081201

• Differential effects of imatinib mesylate against uveal melanoma in vitro and in vivo.

  Melanoma research 20081201

• Radiochemotherapy in patients with primary glioblastoma comparing two temozolomide dose regimens: is the survival really so impressive?: in regard to Combs et al. (Int J Radiat Oncol Biol Phys 2008;71:999-1005).

  International journal of radiation oncology, biology, physics 20081201

• Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081201

• Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081201

• Combining bevacizumab with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model.

  Neoplasia (New York, N.Y.) 20081201

• Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.

  Molecular cancer therapeutics 20081201

• IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression.

  Molecular cancer therapeutics 20081201

• Radiotherapy followed by adjuvant temozolomide treatment of malignant glioma.

  Surgical neurology 20081201

• Pituitary carcinoma presenting with multiple metastases: case report.

  Journal of child neurology 20081201

• Prospective trial of gross-total resection with Gliadel wafers followed by early postoperative Gamma Knife radiosurgery and conformal fractionated radiotherapy as the initial treatment for patients with radiographically suspected, newly diagnosed glioblastoma multiforme.

  Journal of neurosurgery 20081201

• Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide.

  Acta neurologica Belgica 20081201

• Systems biology: a therapeutic target for tumor therapy.

  Cancer microenvironment : official journal of the International Cancer Microenvironment Society 20081201

• Rituximab in the treatment of non-Hodgkin's lymphoma.

  Biologics : targets & therapy 20081201

• Therapeutic vaccines for malignant brain tumors.

  Biologics : targets & therapy 20081201

• Novel microtubule-targeting agents - the epothilones.

  Biologics : targets & therapy 20081201

• Proapoptotic receptor agonists, targeted radionuclide therapy, and the treatment of central nervous system malignancies: in regard to Fiveash et Al. (Int J Radiat Oncol Biol Phys 2008;71:507-516).

  International journal of radiation oncology, biology, physics 20081115

• Antitumor efficacy testing in rodents.

  Journal of the National Cancer Institute 20081105

• Temozolomide treatment does not affect topiramate and oxcarbazepine plasma concentrations in chronically treated patients with brain tumor-related epilepsy.

  Journal of neuro-oncology 20081101

• Enhanced antitumor effect of combined-modality treatment using convection-enhanced delivery of hydrophilic nitrosourea with irradiation or systemic administration of temozolomide in intracranial brain tumor xenografts.

  Neurological research 20081101

• Disseminated salmonellosis in a patient treated with temozolomide.

  The Journal of infection 20081101

• Therapeutic efficacy of a herpes simplex virus with radiation or temozolomide for intracranial glioblastoma after convection-enhanced delivery.

  Molecular therapy : the journal of the American Society of Gene Therapy 20081101

• Phase 2 trial of temozolomide using protracted low-dose and whole-brain radiotherapy for nonsmall cell lung cancer and breast cancer patients with brain metastases.

  Cancer 20081101

• Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma).

  Expert opinion on investigational drugs 20081101

• Safety profile of carmustine wafers in malignant glioma: a review of controlled trials and a decade of clinical experience.

  Current medical research and opinion 20081101

• Characterization of a side population of astrocytoma cells in response to temozolomide.

  Journal of neurosurgery 20081101

• Pathway targets to explore in the treatment of non-small cell lung cancer.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20081101

• Association between response to primary treatments and MGMT status in glioblastoma.

  Expert review of anticancer therapy 20081101

• Treatment-related myelodysplastic syndrome after temozolomide use in a child: first report.

  Journal of pediatric hematology/oncology 20081101

• Methylation status of MGMT gene promoter in meningiomas.

  Cancer genetics and cytogenetics 20081101

• Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide.

  Molecular cancer therapeutics 20081101

• Erythropoietin augments survival of glioma cells after radiation and temozolomide.

  International journal of radiation oncology, biology, physics 20081101

• Randomized study of postoperative radiotherapy and simultaneous temozolomide without adjuvant chemotherapy for glioblastoma.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20081101

• Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor.

  PLoS biology 20081101

• 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

  Journal of medicinal chemistry 20081023

• Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20081020

• An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors.

  Analytical biochemistry 20081015

• Temozolomide rechallenge in recurrent malignant glioma by using a continuous temozolomide schedule: the 'rescue' approach.

  Cancer 20081015

• Temozolomide, thalidomide, and whole brain radiation therapy for patients with brain metastasis from metastatic melanoma: a phase II Cytokine Working Group study.

  Cancer 20081015

• DNA repair enzyme expression and differential response to temozolomide in a patient with both glioblastoma and metastatic pancreatic neuroendocrine tumor.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20081010

• Temozolomide for high grade glioma.

  The Cochrane database of systematic reviews 20081008

• Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker?

  British journal of cancer 20081007

• DNA repair and cancer stem-like cells--potential partners in glioma drug resistance?

  Cancer treatment reviews 20081001

• Recurrent metastatic neuroblastoma followed by myelodysplastic syndrome: possible leukemogenic role of temozolomide.

  Pediatric blood & cancer 20081001

• A phase 2 trial of sequential temozolomide chemotherapy followed by high-dose interleukin 2 immunotherapy for metastatic melanoma.

  Cancer 20081001

• Current clinical and research approaches to optimizing regional chemotherapy: novel strategies generated through a better understanding of drug pharmacokinetics, drug resistance, and the development of clinically relevant animal models.

  Surgical oncology clinics of North America 20081001

• Effects, in an in-vivo model system, of 1,2,3,4-tetrahydroisoquinoline on glioma.

  Anti-cancer drugs 20081001

• Feasibility of using bevacizumab with radiation therapy and temozolomide in newly diagnosed high-grade glioma.

  International journal of radiation oncology, biology, physics 20081001

• PARP inhibitors and cancer therapy - early results and potential applications.

  The British journal of radiology 20081001

• A multicenter phase I trial of interferon-beta and temozolomide combination therapy for high-grade gliomas (INTEGRA Study).

  Japanese journal of clinical oncology 20081001

• Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.

  Molecular cancer research : MCR 20081001

• Designer therapies for glioblastoma multiforme.

  Annals of the New York Academy of Sciences 20081001

• Quality of life in brain metastases radiation trials: a literature review.

  Current oncology (Toronto, Ont.) 20081001

• Engineering of clinical glioma treatment: prediction of pro-invasive molecular events in treated gliomas.

  Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 20081001

• [Orthogonal experiments for optimizing the formulation and preparation conditions of temozolomide solid lipid nanoparticles].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20081001

• The outcomes of concomitant chemoradiotherapy followed by adjuvant chemotherapy with temozolomide for newly diagnosed high grade gliomas : the preliminary results of single center prospective study.

  Journal of Korean Neurosurgical Society 20081001

• Survival from brain tumours in England and Wales up to 2001.

  British journal of cancer 20080923

• Non-Hodgkin's lymphoma in patients with glioma treated with temozolomide.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080920

• The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling.

  Oncogene 20080904

• Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

  British journal of cancer 20080902

• Phase II trial of imatinib mesylate in patients with metastatic melanoma.

  British journal of cancer 20080902

• Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas.

  Surgical neurology 20080901

• Temozolomide three weeks on and one week off as first line therapy for patients with recurrent or progressive low grade gliomas.

  Journal of neuro-oncology 20080901

• Relationship of glioblastoma multiforme to the lateral ventricles predicts survival following tumor resection.

  Journal of neuro-oncology 20080901

• A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis.

  Journal of neuro-oncology 20080901

• Radiochemotherapy with temozolomide as re-irradiation using high precision fractionated stereotactic radiotherapy (FSRT) in patients with recurrent gliomas.

  Journal of neuro-oncology 20080901

• CPT-11 for recurrent temozolomide-refractory 1p19q co-deleted anaplastic oligodendroglioma.

  Journal of neuro-oncology 20080901

• Infrequent promoter methylation of the MGMT gene in liver metastases from uveal melanoma.

  International journal of cancer 20080901

• Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells.

  Gene therapy 20080901

• Temozolomide for recurrent low-grade spinal cord gliomas in adults.

  Cancer 20080901

• Frequently asked questions in the medical management of high-grade glioma: a short guide with practical answers.

  Annals of oncology : official journal of the European Society for Medical Oncology 20080901

• Low-grade glioma: a challenge in therapeutic options: the role of radiotherapy.

  Annals of oncology : official journal of the European Society for Medical Oncology 20080901

• [Alveolo-interstitial pneumonia due to Temozolamide].

  Revue des maladies respiratoires 20080901

• Invasive tumor cells and prognosis in a selected population of patients with glioblastoma multiforme.

  Cancer 20080815

• The development of xenograft glioblastoma implants in nude mice brain.

  Journal of medicine and life 20080815

• Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20080801

• Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability.

  International journal of radiation oncology, biology, physics 20080801

• Glioblastoma in adults.

  Critical reviews in oncology/hematology 20080801

• Comparative evaluation of radiochemotherapy with temozolomide versus standard-of-care postoperative radiation alone in patients with WHO grade III astrocytic tumors.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20080801

• Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme.

  Journal of neuro-oncology 20080801

• Low grade astrocytoma presenting with visual loss.

  Journal of neuro-oncology 20080801

• Cryptococcal meningitis in patients with glioma: a report of two cases.

  Journal of neuro-oncology 20080801

• Multifocal glioblastoma multiforme with synchronous spontaneous hemorrhage: case report.

  Journal of neuro-oncology 20080801

• Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide.

  Molecular pharmacology 20080801

• Phase I safety study of escalating doses of atrasentan in adults with recurrent malignant glioma.

  Neuro-oncology 20080801

• A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhood.

  Neuro-oncology 20080801

• Mechanisms of disease: temozolomide and glioblastoma--look to the future.

  Nature clinical practice. Oncology 20080801

• Concurrent radiotherapy with temozolomide followed by adjuvant temozolomide and cis-retinoic acid in children with diffuse intrinsic pontine glioma.

  Neuro-oncology 20080801

• Different initial steps of apoptosis induced by two types of antineoplastic drugs.

  Biochemical pharmacology 20080801

• Increased survivin expression confers chemoresistance to tumor-associated endothelial cells.

  The American journal of pathology 20080801

• Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080801

• Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells.

  Cancer research 20080801

• [Glioblastoma multiforme developing separately from the initial lesion 9 years after successful treatment for gliomatosis cerebri: a case report].

  No shinkei geka. Neurological surgery 20080801

• Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells.

  Molecular cancer research : MCR 20080801

• Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol.

  Archivum immunologiae et therapiae experimentalis 20080801

• The economic impact on families when a child is diagnosed with cancer.

  Current oncology (Toronto, Ont.) 20080801

• Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas.

  Neurosurgery 20080801

• Optimizing radiotherapy of brain tumours by a combination of temozolomide & lonidamine.

  The Indian journal of medical research 20080801

• In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

  British journal of cancer 20080722

• Radiochemotherapy in patients with primary glioblastoma comparing two temozolomide dose regimens.

  International journal of radiation oncology, biology, physics 20080715

• Incidence of early pseudo-progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomide.

  Cancer 20080715

• Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.

  Bioorganic & medicinal chemistry 20080715

• Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.

  Bioorganic & medicinal chemistry letters 20080715

• Temozolomide preferentially depletes cancer stem cells in glioblastoma.

  Cancer research 20080715

• Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis.

  British journal of cancer 20080708

• Polymorphs and polymorphic cocrystals of temozolomide.

  Chemistry, an Asian journal 20080707

• Temozolomide in combination with fotemustine in patients with metastatic melanoma.

  Cancer chemotherapy and pharmacology 20080701

• Two metachronous tumors induced by radiation therapy: case report and review of the literature.

  Journal of neuro-oncology 20080701

• A retrospective study of the safety of BCNU wafers with concurrent temozolomide and radiotherapy and adjuvant temozolomide for newly diagnosed glioblastoma patients.

  Journal of neuro-oncology 20080701

• Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature.

  Brain pathology (Zurich, Switzerland) 20080701

• AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition.

  Molecular pharmacology 20080701

• Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance.

  Molecular pharmacology 20080701

• Second-line chemotherapy with fotemustine in temozolomide-pretreated patients with relapsing glioblastoma: a single institution experience.

  Anti-cancer drugs 20080701

• Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma.

  The Journal of molecular diagnostics : JMD 20080701

• Individual adjuvant therapy for malignant gliomas based on O6-methylguanine-DNA methyltransferase messenger RNA quantitation by real-time reverse-transcription polymerase chain-reaction.

  Oncology reports 20080701

• Low-grade gliomas in adults.

  Current treatment options in neurology 20080701

• Glioblastoma multiforme.

  Current treatment options in neurology 20080701

• Anaplastic oligodendroglioma.

  Current treatment options in neurology 20080701

• Metastatic melanoma: scientific rationale for sorafenib treatment and clinical results.

  Onkologie 20080701

• Impact of p53 status to response of temozolomide in low MGMT expression glioblastomas: preliminary results.

  Neurological research 20080701

• Major Advances in the Treatment of Cancer: What does a Non-Oncologist need to know?

  Sultan Qaboos University medical journal 20080701

• Stem cell-related 'self-renewal' signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080620

• Prognostic molecular markers with no impact on decision-making: the paradox of gliomas based on a prospective study.

  British journal of cancer 20080603

• Oligodendroglioma.

  Critical reviews in oncology/hematology 20080601

• Evidence of galectin-1 involvement in glioma chemoresistance.

  Toxicology and applied pharmacology 20080601

• Complete response after one cycle of temozolomide in an elderly patient with glioblastoma and poor performance status.

  Journal of neuro-oncology 20080601

• Safety and pharmacokinetics of dose-intensive imatinib mesylate plus temozolomide: phase 1 trial in adults with malignant glioma.

  Neuro-oncology 20080601

• Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults.

  Neuro-oncology 20080601

• FDG-PET imaging for the evaluation of antiglioma agents in a rat model.

  Neuro-oncology 20080601

• Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity.

  European journal of cancer (Oxford, England : 1990) 20080601

• Enhancement of glioma radiotherapy and chemotherapy response with targeted antibody therapy against death receptor 5.

  International journal of radiation oncology, biology, physics 20080601

• Management of malignant glioma--quo vadis?

  Onkologie 20080601

• Temozolomide in newly diagnosed malignant gliomas: administered concomitantly with radiotherapy, and thereafter as consolidation treatment.

  Onkologie 20080601

• The role of temozolomide in newly-diagnosed glioblastoma multiforme.

  British journal of neurosurgery 20080601

• [Current topics of treatment for glioma and mechanism of drug resistance].

  Gan to kagaku ryoho. Cancer & chemotherapy 20080601

• Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance.

  Biologics : targets & therapy 20080601

• A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.

  British journal of cancer 20080520

• Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment.

  Cancer research 20080515

• Phase II study of extended-dose temozolomide in patients with melanoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080510

• Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study.

  Cancer chemotherapy and pharmacology 20080501

• Up-regulation of vimentin expression in low-density malignant glioma cells as immediate and late effects under irradiation and temozolomide treatment.

  Amino acids 20080501

• Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model.

  Journal of neuro-oncology 20080501

• The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastoma.

  Journal of neuro-oncology 20080501

• Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients.

  Journal of neuro-oncology 20080501

• Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients.

  Journal of neuro-oncology 20080501

• Solid lipid nanoparticles of temozolomide: potential reduction of cardial and nephric toxicity.

  International journal of pharmaceutics 20080501

• Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3.

  Autophagy 20080501

• The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study.

  Journal of neuro-oncology 20080501

• Treatment of recurrent glioblastoma: can local delivery of mitoxantrone improve survival?

  Journal of neuro-oncology 20080501

• Salvage chemotherapy with CPT-11 for recurrent temozolomide-refractory anaplastic astrocytoma.

  Cancer 20080501

• Focus on FOCIS: interleukin 2 treatment associated autoimmunity.

  Clinical immunology (Orlando, Fla.) 20080501

• Knocking down galectin 1 in human hs683 glioblastoma cells impairs both angiogenesis and endoplasmic reticulum stress responses.

  Journal of neuropathology and experimental neurology 20080501

• Modulatory effects of acetazolomide and dexamethasone on temozolomide-mediated apoptosis in human glioblastoma T98G and U87MG cells.

  Cancer investigation 20080501

• MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080501

• Temozolomide-mediated radiosensitization of human glioma cells in a zebrafish embryonic system.

  Cancer research 20080501

• Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas.

  The Lancet. Oncology 20080501

• Adjuvant temozolomide: how long and how much?

  Expert review of anticancer therapy 20080501

• Combi-targeting concept: an optimized single-molecule dual-targeting model for the treatment of chronic myelogenous leukemia.

  Molecular cancer therapeutics 20080501

• [On the occasion of my retirement as head of the Neurochirurgische Universitätsklinik Zürich--changing aspects of treatment modality in modern neurosurgery and of neuroscience research. Presentation of our experience and historical backgrounds].

  Brain and nerve = Shinkei kenkyu no shinpo 20080501

• When temozolomide alone fails: adding procarbazine in salvage therapy of glioma.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20080501

• A pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients.

  British journal of cancer 20080422

• Noninvasive imaging of apoptosis and its application in cancer therapeutics.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080415

• Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.

  Cancer cell 20080408

• A combination of IFN-beta and temozolomide in human glioma xenograft models: implication of p53-mediated MGMT downregulation.

  Cancer chemotherapy and pharmacology 20080401

• Salvage chemotherapy with procarbazine and fotemustine combination in the treatment of temozolomide treated recurrent glioblastoma patients.

  Journal of neuro-oncology 20080401

• An orthotopic skull base model of malignant meningioma.

  Brain pathology (Zurich, Switzerland) 20080401

• Temozolomide plus pegylated interferon alfa-2b as first-line treatment for stage IV melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group (DeCOG).

  Annals of oncology : official journal of the European Society for Medical Oncology 20080401

• Brain and leptomeningeal metastases from cutaneous melanoma: survival outcomes based on clinical features.

  Neuro-oncology 20080401

• A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost.

  Neuro-oncology 20080401

• Temozolomide associated with PEG-interferon in patients with metastatic melanoma: a multicenter prospective phase I/II study.

  Melanoma research 20080401

• Phase II trial of arsenic trioxide and ascorbic acid with temozolomide in patients with metastatic melanoma with or without central nervous system metastases.

  Melanoma research 20080401

• The integrin antagonist cilengitide increases the antitumor activity of temozolomide against malignant melanoma.

  Oncology reports 20080401

• Translational research in glioblastoma multiforme: molecular criteria for patient selection.

  Future oncology (London, England) 20080401

• [Genetic diagnoses and individualized treatment of gliomas].

  No shinkei geka. Neurological surgery 20080401

• Anaplastic astrocytomas: biology and treatment.

  Expert review of neurotherapeutics 20080401

• A rare case of melanoma recurring as subcutaneous metastatic melanoma with overlying ecchymoses.

  Archives of dermatology 20080401

• A multivariate analysis of patients with glioma: a treatment outcome and prognostic factor for survival.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080401

• Cerebellar glioblastoma multiforme in an adult.

  Journal of Korean Neurosurgical Society 20080401

• Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patients.

  International journal of radiation oncology, biology, physics 20080315

• MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome.

  International journal of cancer 20080315

• Cost-effectiveness of temozolomide for the treatment of newly diagnosed glioblastoma multiforme: a report from the EORTC 26981/22981 NCI-C CE3 Intergroup Study.

  Cancer 20080315

• Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma.

  Pediatric blood & cancer 20080301

• A phase II trial of vinorelbine and intensive temozolomide for patients with recurrent or progressive brain metastases.

  Journal of neuro-oncology 20080301

• Fixed dose-rate gemcitabine as radiosensitizer for newly diagnosed glioblastoma: a dose-finding study.

  Journal of neuro-oncology 20080301

• Variation of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma.

  Journal of neuro-oncology 20080301

• Multi-institutional phase II study of temozolomide administered twice daily in the treatment of recurrent high-grade gliomas.

  Cancer 20080301

• Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.

  Pharmacotherapy 20080301

• An investigation of boron neutron capture therapy for recurrent glioblastoma multiforme.

  Acta neurologica Scandinavica 20080301

• Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080301

• Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma.

  Cancer research 20080301

• Emerging drugs for malignant glioma.

  Expert opinion on emerging drugs 20080301

• [Report of the 10th Annual Meeting of the Chinese society of Clinical Oncology].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080301

• [Temozolomide: Temodal].

  Gan to kagaku ryoho. Cancer & chemotherapy 20080301

• Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies.

  Expert review of anticancer therapy 20080301

• Glioblastoma in a patient with a hereditary cancer syndrome.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20080301

• [The sodium pump could constitute a new target to combat glioblastomas].

  Bulletin du cancer 20080301

• Recent advances in blood-brain barrier disruption as a CNS delivery strategy.

  The AAPS journal 20080301

• Clinical uses of GM-CSF, a critical appraisal and update.

  Biologics : targets & therapy 20080301

• Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080220

• Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri.

  Neurology 20080219

• Clinical pharmacology of cancer therapies in older adults.

  British journal of cancer 20080212

• MGMT immunoexpression predicts responsiveness of pituitary tumors to temozolomide therapy.

  Acta neuropathologica 20080201

• Defining the standard of care for high-grade glioma--a NICE deal for patients.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20080201

• In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomide.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080201

• Targeting the epidermal growth factor receptor in high-grade astrocytomas.

  Current treatment options in oncology 20080201

• [Chemotherapy for brain tumors in adult patients].

  Der Nervenarzt 20080201

• [Recent advances in chemotherapy for malignant gliomas].

  No shinkei geka. Neurological surgery 20080201

• Natural history and management of brainstem gliomas in adults. A retrospective Italian study.

  Journal of neurology 20080201

• Midline glioblastoma multiforme with bilateral symmetric cysts.

  Journal of Korean Neurosurgical Society 20080201

• Epigenetic silencing of telomerase and a non-alkylating agent as a novel therapeutic approach for glioma.

  Brain research 20080110

• Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy.

  Cancer immunology, immunotherapy : CII 20080101

• Predictors of distant brain recurrence for patients with newly diagnosed brain metastases treated with stereotactic radiosurgery alone.

  International journal of radiation oncology, biology, physics 20080101

• Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma.

  Neuro-oncology 20080101

• Pilot trial of the rate of response, safety, and tolerability of temozolomide and oral VP-16 in patients with recurrent or treatment-induced malignant central nervous system tumors.

  Surgical neurology 20080101

• Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study.

  Neuro-oncology 20080101

• Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3.

  The Lancet. Oncology 20080101

• Cannabinoids as potential new therapy for the treatment of gliomas.

  Expert review of neurotherapeutics 20080101

• Temozolomide and resistant glioma cells.

  Journal of neurosurgery 20080101

• Nomograms as clinicobiological predictors of survival in glioblastoma.

  The Lancet. Oncology 20080101

• Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas.

  Cerebrospinal fluid research 20080101

• Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization.

  Molecular cancer therapeutics 20080101

• Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma.

  PLoS medicine 20080101

• Incorporating molecular tools into early-stage clinical trials.

  PLoS medicine 20080101

• Induction of gliosarcoma and atypical meningioma 13 years after radiotherapy of residual pilocytic astrocytoma in childhood.

  Pediatric neurosurgery 20080101

• [Treatment of marignant brain tumor: today and tomorrow].

  No shinkei geka. Neurological surgery 20080101

• [Molecular genetic analysis for malignant gliomas: clinical implications and future directions].

  No shinkei geka. Neurological surgery 20080101

• Overcoming therapeutic resistance in malignant gliomas: current practices and future directions.

  Cancer treatment and research 20080101

• Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.

  Retrovirology 20080101

• Astroblastoma with rhabdoid features and favorable long-term outcome: report of a case with a 12-year follow-up.

  Pathology, research and practice 20080101

• A multicenter cohort study of dose-dense temozolomide (21 of 28 days) for the treatment of recurrent anaplastic astrocytoma or oligoastrocytoma.

  Cancer investigation 20080101

• An integrative genomic and epigenomic approach for the study of transcriptional regulation.

  PloS one 20080101

• Advanced cutaneous malignant melanoma: a systematic review of economic and quality-of-life studies.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080101

• Dihydroartemisinin potentiates the cytotoxic effect of temozolomide in rat C6 glioma cells.

  Pharmacology 20080101

• Morphologically and immunohistochemically undifferentiated gastric neoplasia in a patient with multiple metastatic malignant melanomas: a case report.

  Journal of medical case reports 20080101

• Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma.

  Journal of translational medicine 20080101

• Extra central nervous system metastases from cerebral glioblastoma multiforme in elderly patients. Clinico-pathological remarks on our series of seven cases and critical review of the literature.

  Tumori 20080101

• Increased seroreactivity to glioma-expressed antigen 2 in brain tumor patients under radiation.

  PloS one 20080101

• Highly proliferative neuroendocrine carcinoma - influence of radiotherapy fractionation on tumor response.

  Radiation oncology (London, England) 20080101

• A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors.

  Cancer cell international 20080101

• Congenital glioblastoma multiforme: case report and review of the literature.

  Pediatric neurosurgery 20080101

• PPARgamma in Neuroblastoma.

  PPAR research 20080101

• Fibrin sealant does not decrease seroma output or time to drain removal following inguino-femoral lymph node dissection in melanoma patients: a randomized controlled trial (NCT00506311).

  World journal of surgical oncology 20080101

• [Therapeutic strategies for the management of gliomas].

  Revue neurologique 20080101

• Outpatient and home chemotherapy with novel local control strategies in desmoplastic small round cell tumor.

  Sarcoma 20080101

• A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier.

  PloS one 20080101

• PPARgamma and MEK Interactions in Cancer.

  PPAR research 20080101

• A phase II study of thalidomide in patients with brain metastases from malignant melanoma.

  Acta oncologica (Stockholm, Sweden) 20080101

• Effects of palliative treatment with temozolomide in patients with high-grade gliomas.

  Neurologia i neurochirurgia polska 20080101

• Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study.

  BMC cancer 20080101

• Cytotoxic and apoptotic effects of bortezomib and gefitinib compared to alkylating agents on human glioblastoma cells.

  Journal of experimental therapeutics & oncology 20080101

• [Multivariate analysis of prognostic factors and survival in patients with 'glioblastoma multiforme'].

  La Clinica terapeutica 20080101

• TMZ-BioShuttle--a reformulated temozolomide.

  International journal of medical sciences 20080101

• Neuropsychological testing and biomarkers in the management of brain metastases.

  Radiation oncology (London, England) 20080101

• Aggressive papillary glioneuronal tumor: case report and literature review.

  Clinical neuropathology 20080101

• Concomitant radiochemotherapy in a patient with multiple sclerosis and glioblastoma.

  Clinical neuropathology 20080101

• The prognostic value of nestin expression in newly diagnosed glioblastoma: report from the Radiation Therapy Oncology Group.

  Radiation oncology (London, England) 20080101

• Gliosarcomas in the elderly: analysis of 7 cases and clinico-pathological remarks.

  Tumori 20080101

• Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines.

  Journal of translational medicine 20080101

• Short-term effective treatment of CNS metastasis of sarcomatoid renal cell carcinoma with temozolomide and pegylated liposomal doxorubicin: A case report.

  Cases journal 20080101

• Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age.

  BMC medical genomics 20080101

• Case report on a patient with neurofibromatosis type 1 and a frontal cystic glioblastoma.

  Neurologia i neurochirurgia polska 20080101

• Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma.

  Journal of experimental & clinical cancer research : CR 20080101

• Radiotherapy-related tiredness in patients with glioblastoma multiforme (GBM).

  Asian Pacific journal of cancer prevention : APJCP 20080101

• Discovery of DNA methylation markers in cervical cancer using relaxation ranking.

  BMC medical genomics 20080101

• Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet.

  Nutrition & metabolism 20080101

• The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo.

  Anticancer research 20080101

• Phase II Study of Temozolomide and Thalidomide in Patients with Unresectable or Metastatic Leiomyosarcoma.

  Sarcoma 20080101

• A highly invasive human glioblastoma pre-clinical model for testing therapeutics.

  Journal of translational medicine 20080101

• Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells.

  Journal of translational medicine 20080101

• [(18)F]Fluoroethyltyrosine- positron emission tomography-guided radiotherapy for high-grade glioma.

  Radiation oncology (London, England) 20080101

• Carboplatin and oral cyclophosphamide combination after temozolomide failure in malignant gliomas.

  Tumori 20080101

• Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway.

  Journal of experimental & clinical cancer research : CR 20080101

• Clinical Use of PPARgamma Ligands in Cancer.

  PPAR research 20080101

• Aspergillus terreus brain abscess mimicking tumor progression in a patient with treated glioblastoma multiforme.

  Clinical neuropathology 20080101

• MSH6 inactivation and emergent temozolomide resistance in human glioblastomas.

  Clinical neurosurgery 20080101

• Reinduction of bevacizumab in combination with pegylated liposomal Doxorubicin in a patient with recurrent glioblastoma multiforme who progressed on bevacizumab/irinotecan.

  Journal of oncology 20080101

• Disappearance of gadolinium enhancement in a chemoresistant astrocytoma of the tectum after high-dose interferon beta.

  Tumori 20080101

• Stat3 expression and its correlation with proliferation and apoptosis/autophagy in gliomas.

  Journal of oncology 20080101

• Delayed diagnosis of brain tumor in a patient with flexor spasms and spastic foot drop.

  Annals of Indian Academy of Neurology 20080101

• Treatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistry.

  Drug design, development and therapy 20080101

• [Efficiency of radiation or chemoradiation therapy for diffusely growing brainstem tumors in children].

  Vestnik rentgenologii i radiologii 20080101

• Rechallenge with temozolomide with different scheduling is effective in recurrent malignant gliomas.

  Molecular medicine reports 20080101

• Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma-a critical review.

  Clinical medicine. Oncology 20080101

• A Single Institution's Experience with Bevacizumab in Combination with Cytotoxic Chemotherapy in Progressive Malignant Glioma.

  Clinical medicine. Oncology 20080101

• 2007 EORTC-NCI-ASCO annual meeting: molecular markers in cancer.

  Ecancermedicalscience 20080101

• A phase II study of thalidomide and temozolomide in patients with brain metastases from malignant melanoma: lymphopenia correlates with response.

  Ecancermedicalscience 20080101

• Primary central nervous system lymphomas: salvage treatment after failure to high-dose methotrexate.

  Cancer letters 20071218

• Combining adenoviral oncolysis with temozolomide improves cell killing of melanoma cells.

  International journal of cancer 20071215

• Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter.

  Cancer research 20071215

• Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks.

  Cancer research 20071215

• Enhanced antitumour immunity by combined use of temozolomide and TAT-survivin pulsed dendritic cells in a murine glioma.

  Immunology 20071201

• Temozolomide and radiation in low-grade and anaplastic gliomas: temoradiation.

  Cancer investigation 20071201

• Editorial: what is new in the treatment of gliomas?

  Current opinion in neurology 20071201

• Incorporating molecular tools into clinical trials and treatment for gliomas?

  Current opinion in neurology 20071201

• Management of glioblastoma.

  Expert opinion on pharmacotherapy 20071201

• Postoperative radiotherapy of glioblastoma multiforme: analysis and critical assessment of different treatment strategies and predictive factors.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20071201

• Phase I study of temozolomide and irinotecan for recurrent malignant gliomas in patients receiving enzyme-inducing antiepileptic drugs: a north american brain tumor consortium study.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20071201

• Diffusion tensor imaging and chemical shift imaging assessment of heterogeneity in low grade glioma under temozolomide chemotherapy.

  Cancer investigation 20071201

• Acquired hypopigmentation (leukoderma) as a presenting feature of metastatic amelanotic melanoma with brain involvement.

  Archives of neurology 20071201

• Encouraging experience of concomitant Temozolomide with radiotherapy followed by adjuvant Temozolomide in newly diagnosed glioblastoma multiforme: single institution experience.

  British journal of neurosurgery 20071201

• Prognostic significance of O6-methylguanine-DNA methyltransferase protein expression in patients with recurrent glioblastoma treated with temozolomide.

  Japanese journal of clinical oncology 20071201

• Clinical course of high-grade glioma patients with a 'biopsy-only' surgical approach: a need for individualised treatment.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20071201

• Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas.

  The oncologist 20071201

• Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide.

  Therapeutics and clinical risk management 20071201

• Topotecan: An evolving option in the treatment of relapsed small cell lung cancer.

  Therapeutics and clinical risk management 20071201

• The RAS/mitogen activated protein (MAP) kinase pathway in melanoma biology and therapeutics.

  Biologics : targets & therapy 20071201

• Cisplatin, gemcitabine, and treosulfan in relapsed stage IV cutaneous malignant melanoma patients.

  British journal of cancer 20071119

• Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines.

  International journal of radiation oncology, biology, physics 20071115

• Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20071115

• AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20071115

• Temozolomide induces senescence but not apoptosis in human melanoma cells.

  British journal of cancer 20071105

• O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines.

  Cancer chemotherapy and pharmacology 20071101

• Prolonged and severe myelosuppression in two patients after low-dose temozolomide treatment- case study and review of literature.

  Journal of neuro-oncology 20071101

• Temozolomide in pediatric low-grade glioma.

  Pediatric blood & cancer 20071101

• Diffuse glioma growth: a guerilla war.

  Acta neuropathologica 20071101

• Marked response to a cisplatin/docetaxel/temozolomide combination in a heavily pretreated patient with metastatic large cell neuroendocrine lung carcinoma.

  Anti-cancer drugs 20071101

• Temozolomide and methotrexate for primary central nervous system lymphoma in the elderly.

  Journal of neuro-oncology 20071101

• Molecular targeted therapies and chemotherapy in malignant gliomas.

  Current opinion in oncology 20071101

• Molecular genetic markers as predictors of response to chemotherapy in gliomas.

  Current opinion in oncology 20071101

• Combined effect of 2-5A-linked antisense against telomerase RNA and conventional therapies on human malignant glioma cells in vitro and in vivo.

  International journal of oncology 20071101

• Diagnosis and treatment of high-grade astrocytoma.

  Neurologic clinics 20071101

• Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071101

• The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation.

  Health technology assessment (Winchester, England) 20071101

• Adjuvant chemotherapy for adults with malignant glioma: a systematic review.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20071101

• Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results.

  Neurosurgery 20071101

• Radiotherapy and radiosensitizers in the treatment of glioblastoma multiforme.

  Clinical advances in hematology & oncology : H&O 20071101

• [The effect of oxygenation on the biological behaviour of tumours].

  Orvosi hetilap 20071028

• Potential biochemical therapy of glioma cancer.

  Biochemical and biophysical research communications 20071019

• The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

  Cancer research 20071015

• Adenovirally delivered tumor necrosis factor-alpha improves the antiglioma efficacy of concomitant radiation and temozolomide therapy.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20071015

• Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model.

  Cancer chemotherapy and pharmacology 20071001

• Galectin-1 knockdown increases sensitivity to temozolomide in a B16F10 mouse metastatic melanoma model.

  The Journal of investigative dermatology 20071001

• Unexpected case of aplastic anemia in a patient with glioblastoma multiforme treated with Temozolomide.

  Journal of neuro-oncology 20071001

• Patients receiving standard-dose temozolomide therapy are at risk of Pneumocystis carinii pneumonia.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20071001

• MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas.

  Laboratory investigation; a journal of technical methods and pathology 20071001

• Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.

  Cancer 20071001

• What approach will lead to cure of glioblastoma multiforme? In regard to Barani et al. (Int J Radiat Oncol Biol Phys 2007;68:324-333) and Jones and Sanghera (Int J Radiat Oncol Biol Phys 2007;68:441-448).

  International journal of radiation oncology, biology, physics 20071001

• Triazene compounds: mechanism of action and related DNA repair systems.

  Pharmacological research 20071001

• Pharmacokinetic study of temozolomide on a daily-for-5-days schedule in Japanese patients with relapsed malignant gliomas: first study in Asians.

  International journal of clinical oncology 20071001

• O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells.

  Molecular cancer therapeutics 20071001

• Gliadel wafers in the treatment of malignant glioma: a systematic review.

  Current oncology (Toronto, Ont.) 20071001

• Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas.

  Therapeutics and clinical risk management 20071001

• Biochemotherapy of metastatic melanoma in patients with or without recently diagnosed brain metastases.

  Cancer 20070915

• Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070915

• Use of molecular biomarkers for predicting the response to radiotherapy with or without chemotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070910

• Chemoradiotherapy in malignant glioma: standard of care and future directions.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070910

• Durable response of a radiation-induced, high-grade cerebellar glioma to temozolomide.

  Journal of neuro-oncology 20070901

• [What type of adjuvant chemotherapy should be proposed for the initial treatment of glioblastoma?].

  Presse medicale (Paris, France : 1983) 20070901

• Change in expression of MGMT during maturation of human monocytes into dendritic cells.

  DNA repair 20070901

• Defining the standard of care for high-grade glioma--a NICE deal for UK patients?

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20070901

• Impact of combination therapy with repeat surgery and temozolomide for recurrent or progressive glioblastoma multiforme: a prospective trial.

  Surgical neurology 20070901

• [Role of MGMT and clinical applications in brain tumours].

  Bulletin du cancer 20070901

• [A practical guide for the management of gliomas].

  Bulletin du cancer 20070901

• Temozolomide treatment of an adult with a relapsing medulloblastoma.

  Cancer investigation 20070901

• Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy.

  Journal of neurosurgery 20070901

• Temozolomide for the treatment of metastatic melanoma: a systematic review.

  The oncologist 20070901

• Chemotherapy and delivery in the treatment of primary brain tumors.

  Current clinical pharmacology 20070901

• Diagnosis and management of primary intraocular lymphoma: an update.

  Clinical ophthalmology (Auckland, N.Z.) 20070901

• The neuro-steroid, 3beta androstene 17alpha diol exhibits potent cytotoxic effects on human malignant glioma and lymphoma cells through different programmed cell death pathways.

  British journal of cancer 20070828

• Targeting HER proteins in cancer therapy and the role of the non-target HER3.

  British journal of cancer 20070820

• Efficacy of temozolomide or dacarbazine in combination with an anthracycline for rescue chemotherapy in dogs with lymphoma.

  Journal of the American Veterinary Medical Association 20070815

• The fallacy of single-agent chemotherapy for cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810

• The prognostic value of health-related quality-of-life data in predicting survival in glioblastoma cancer patients: results from an international randomised phase III EORTC Brain Tumour and Radiation Oncology Groups, and NCIC Clinical Trials Group study.

  British journal of cancer 20070806

• Temozolomide in glioblastoma: results of administration at first relapse and in newly diagnosed cases. Is still proposable an alternative schedule to concomitant protocol?

  Journal of neuro-oncology 20070801

• Chemical radiosensitizers for use in radiotherapy.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20070801

• O6-methylguanine-DNA-methyltransferase (MGMT) gene therapy targeting haematopoietic stem cells: studies addressing safety issues.

  DNA repair 20070801

• Novel role of triazenes in haematological malignancies: pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia.

  DNA repair 20070801

• Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo.

  Cancer gene therapy 20070801

• Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070801

• The economics of temozolomide in brain cancer.

  Expert opinion on pharmacotherapy 20070801

• The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity.

  Molecular cancer therapeutics 20070801

• Continuous hyperthermic peritoneal perfusion for desmoplastic small round cell tumor.

  Journal of pediatric surgery 20070801

• Efficacy of temozolomide is correlated with 1p loss and methylation of the deoxyribonucleic acid repair gene MGMT in malignant gliomas.

  Neurologia medico-chirurgica 20070801

• Predicting human tumor drug concentrations from a preclinical pharmacokinetic model of temozolomide brain disposition.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070715

• Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.

  Cancer research 20070715

• Prophylactic radiotherapy for glioblastoma in the elderly.

  The New England journal of medicine 20070712

• Salvage therapy for primary central nervous system lymphoma with (90)Y-Ibritumomab and Temozolomide.

  Journal of neuro-oncology 20070701

• Pulsed reduced dose-rate radiotherapy: case report : a novel re-treatment strategy in the management of recurrent glioblastoma multiforme.

  Journal of neuro-oncology 20070701

• Melanoma of the anus disguised as hemorrhoids: surgical management illustrated by a case report.

  Digestive diseases and sciences 20070701

• Survey of treatment recommendations for anaplastic oligodendroglioma.

  Neuro-oncology 20070701

• Anaplastic astrocytoma in adults.

  Critical reviews in oncology/hematology 20070701

• Comparison of herpes simplex virus- and conditionally replicative adenovirus-based vectors for glioblastoma treatment.

  Cancer gene therapy 20070701

• In vitro responsiveness of glioma cell lines to multimodality treatment with radiotherapy, temozolomide, and epidermal growth factor receptor inhibition with cetuximab.

  International journal of radiation oncology, biology, physics 20070701

• Inhibition of Aurora-B function increases formation of multinucleated cells in p53 gene deficient cells and enhances anti-tumor effect of temozolomide in human glioma cells.

  Journal of neuro-oncology 20070701

• Radiochemotherapy for brain metastasis: how to define a role for temozolomide.

  Onkologie 20070701

• Phase II study of temozolomide and concomitant whole-brain radiotherapy in patients with brain metastases from solid tumors.

  Onkologie 20070701

• Lessons learned in the development of targeted therapy for malignant gliomas.

  Molecular cancer therapeutics 20070701

• Primary central nervous system lymphoma treated with rituximab plus temozolomide in a second line schedule.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20070701

• Tremelimumab (CP-675,206), a cytotoxic T lymphocyte associated antigen 4 blocking monoclonal antibody in clinical development for patients with cancer.

  The oncologist 20070701

• New chemotherapy options for the treatment of malignant gliomas.

  Anti-cancer drugs 20070701

• Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070620

• Mathematical modeling of brain tumors: effects of radiotherapy and chemotherapy.

  Physics in medicine and biology 20070607

• Estimation of radiobiologic parameters and equivalent radiation dose of cytotoxic chemotherapy in malignant glioma.

  International journal of radiation oncology, biology, physics 20070601

• Temozolomide-associated organizing pneumonitis.

  Mayo Clinic proceedings 20070601

• Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models.

  Cancer biology & therapy 20070601

• A phase I study of thalidomide, capecitabine and temozolomide in advanced cancer.

  Cancer biology & therapy 20070601

• Canadian recommendations for the treatment of glioblastoma multiforme.

  Current oncology (Toronto, Ont.) 20070601

• Selective lymphopenia and opportunistic infections in neuroendocrine tumor patients receiving temozolomide.

  Cancer investigation 20070601

• Microemulsions as topical delivery vehicles for the anti-melanoma prodrug, temozolomide hexyl ester (TMZA-HE).

  The Journal of pharmacy and pharmacology 20070601

• Chemotherapy and role of the proliferation marker Ki-67 in digestive neuroendocrine tumors.

  Endocrine-related cancer 20070601

• Hemorrhagic cystitis in a patient receiving conventional doses of dacarbazine for metastatic malignant melanoma: case report and review of the literature.

  Clinical therapeutics 20070601

• Metastatic medulloblastoma in an adult; treatment with temozolomide.

  Acta neurologica Belgica 20070601

• Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors.

  Therapeutics and clinical risk management 20070601

• Temozolomide for low-grade gliomas: predictive impact of 1p/19q loss on response and outcome.

  Neurology 20070522

• Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070515

• Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070515

• Toxicity and efficacy of protracted low dose temozolomide for the treatment of low grade gliomas.

  Journal of neuro-oncology 20070501

• Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.

  Carcinogenesis 20070501

• Malignant transformation of conus medullaris ganglioglioma: case report.

  Journal of neuro-oncology 20070501

• The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents.

  Journal of molecular medicine (Berlin, Germany) 20070501

• A small proportion of glioblastoma patients are probably eligible for concomitant/adjuvant temozolomide.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20070501

• Dynamic history of low-grade gliomas before and after temozolomide treatment.

  Annals of neurology 20070501

• Successful treatment of leptomeningeal disease in colorectal cancer with a regimen of bevacizumab, temozolomide, and irinotecan.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070501

• ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070501

• Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.

  Cancer research 20070501

• Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.

  Molecular cancer therapeutics 20070501

• Extracranial relapse of an anaplastic oligodendroglioma in an adolescent: case report and review of the literature.

  Journal of pediatric hematology/oncology 20070501

• [Chemotherapy for malignant gliomas].

  No shinkei geka. Neurological surgery 20070501

• Adjuvant therapy in glioblastomas: false steps and real advances.

  Expert review of anticancer therapy 20070501

• Complete response to temozolomide treatment in an elderly patient with recurrent primary central nervous system lymphoma--case report.

  Neurologia medico-chirurgica 20070501

• 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs.

  Neoplasia (New York, N.Y.) 20070501

• Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report.

  Journal of neurosurgery. Spine 20070501

• Improved median survival for glioblastoma multiforme following introduction of adjuvant temozolomide chemotherapy.

  Annals of the Academy of Medicine, Singapore 20070501

• Salvage chemotherapy in progressive high-grade astrocytoma.

  Annals of the Academy of Medicine, Singapore 20070501

• Cross-priming by temozolomide enhances antitumor immunity of dendritic cell vaccination in murine brain tumor model.

  Vaccine 20070430

• Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.

  British journal of cancer 20070423

• Methylguanine methyltransferase testing in glioblastoma: when and how?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070420

• Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070420

• Does high-dose carmustine increase overall survival in supratentorial high-grade malignant glioma? An EBMT retrospective study.

  International journal of cancer 20070415

• Fatal reactivation of hepatitis B with temozolomide.

  The New England journal of medicine 20070412

• Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.

  British journal of cancer 20070410

• Taming a mutinous mutant: an errant receptor becomes a prime cancer target.

  Journal of the National Cancer Institute 20070404

• MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma.

  Pediatric blood & cancer 20070401

• A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma.

  Journal of neuro-oncology 20070401

• Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency.

  DNA repair 20070401

• A phase II study of temozolomide therapy for poor-risk patients aged >or=60 years with acute myeloid leukemia: low levels of MGMT predict for response.

  Leukemia 20070401

• Preclinical pharmacokinetic and pharmacodynamic evaluation of metronomic and conventional temozolomide dosing regimens.

  The Journal of pharmacology and experimental therapeutics 20070401

• The inhibition of proliferation and migration of glioma spheroids exposed to temozolomide is less than additive if combined with irradiation.

  Oncology reports 20070401

• Temozolomide in children with progressive low-grade glioma.

  Neuro-oncology 20070401

• [Glioma therapy up-date].

  Neurologia (Barcelona, Spain) 20070401

• Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070401

• MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival.

  Molecular cancer therapeutics 20070401

• Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells.

  Journal of neurosurgery 20070401

• Temozolomide as salvage treatment in primary brain lymphomas.

  British journal of cancer 20070326

• Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma.

  British journal of cancer 20070326

• Hepatitis B reactivation during glioblastoma treatment with temozolomide: a cautionary note.

  Neurology 20070320

• Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma.

  Journal of neuro-oncology 20070301

• DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells.

  Cell death and differentiation 20070301

• Local recurrence and distant metastasis of supratentorial primitive neuro-ectodermal tumor in an adult patient successfully treated with intensive induction chemotherapy and maintenance temozolomide.

  Journal of neuro-oncology 20070301

• Local intracerebral administration of O(6)-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma.

  Journal of neuro-oncology 20070301

• Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours.

  Apoptosis : an international journal on programmed cell death 20070301

• Current topics in melanoma.

  Current opinion in oncology 20070301

• Prognosis factors of survival time in patients with glioblastoma multiforme: a multivariate analysis of 340 patients.

  Acta neurochirurgica 20070301

• Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070301

• Fatal outcome related to carmustine implants in glioblastoma multiforme.

  Acta neurochirurgica 20070301

• Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

  Molecular cancer therapeutics 20070301

• Motexafin gadolinium injection for the treatment of brain metastases in patients with non-small cell lung cancer.

  International journal of nanomedicine 20070301

• Safety and feasibility of long-term temozolomide treatment in patients with high-grade glioma.

  Neurology 20070227

• A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells.

  British journal of cancer 20070226

• Interleukin-6 gene amplification and shortened survival in glioblastoma patients.

  British journal of cancer 20070212

• Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma.

  Pediatric blood & cancer 20070201

• Phase II study with the combination of gemcitabine and DTIC in patients with advanced soft tissue sarcomas.

  Cancer chemotherapy and pharmacology 20070201

• Temozolomide/PLGA microparticles and antitumor activity against glioma C6 cancer cells in vitro.

  International journal of pharmaceutics 20070201

• Administration of temozolomide during and after radiotherapy for newly diagnosed high-grade gliomas excluding glioblastoma multiforme.

  Journal of neuro-oncology 20070201

• A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme.

  Journal of neuro-oncology 20070201

• Ganglioglioma occurring with glioblastoma multiforme: separate lesions or the same lesion?

  Clinical neurology and neurosurgery 20070201

• Combined effect of temozolomide and hyperthermia on human melanoma cell growth and O6-methylguanine-DNA methyltransferase activity.

  International journal of oncology 20070201

• Motexafin gadolinium in the treatment of brain metastases.

  Expert opinion on pharmacotherapy 20070201

• American Society of Hematology--48th Annual Meeting and Exposition. Therapeutic approaches for hematological cancers. 9-12 December 2006 Orlando, FL, USA.

  IDrugs : the investigational drugs journal 20070201

• [Molecular pharmacology on DNA methylating agent temozolomide].

  No shinkei geka. Neurological surgery 20070201

• Single-agent interleukin-2 in the treatment of metastatic melanoma.

  Current oncology (Toronto, Ont.) 20070201

• Temozolomide for the treatment of metastatic melanoma.

  Current oncology (Toronto, Ont.) 20070201

• [Temozolomide, an oral chemotherapeutic agent with potential severe toxicity].

  Nederlands tijdschrift voor geneeskunde 20070127

• HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity.

  Current biology : CB 20070123

• A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma.

  British journal of cancer 20070115

• Temozolomide in advanced malignant melanoma with small brain metastases: can we withhold cranial irradiation?

  Cancer 20070115

• O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells.

  Cancer research 20070115

• Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

  Oncogene 20070111

• Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: Morphological findings.

  Human pathology 20070101

• Non-sufficient cell cycle control as possible clue for the resistance of human malignant glioma cells to clinically relevant treatment conditions.

  Amino acids 20070101

• The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas.

  Neuro-oncology 20070101

• Interindividual differences in anticancer drug cytotoxicity in primary human glioblastoma cells.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20070101

• Therapeutic advances for glioblastoma multiforme: current status and future prospects.

  Current oncology reports 20070101

• Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070101

• New [1,2,4]triazolo[4,3-c]quinazoline enhances cisplatin- and temozolomide-induced growth inhibition and apoptosis in HL-60 cells.

  Neoplasma 20070101

• Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.

  Cancer research 20070101

• Genetic aberrations in gliomatosis cerebri.

  Neurosurgery 20070101

• Concomitant treatment of brain metastasis with whole brain radiotherapy [WBRT] and temozolomide [TMZ] is active and improves quality of life.

  BMC cancer 20070101

• Temozolomide in the treatment of an invasive prolactinoma resistant to dopamine agonists.

  Pituitary 20070101

• MGMT methylation status: the advent of stratified therapy in glioblastoma?

  Disease markers 20070101

• Therapeutic advances in the treatment of brain metastases.

  Clinical advances in hematology & oncology : H&O 20070101

• Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications.

  Molecular cancer 20070101

• Efficacy of different regimens of adjuvant radiochemotherapy for treatment of glioblastoma.

  Tumori 20070101

• A phase I study of cisplatin, temozolomide and thalidomide in patients with malignant brain tumors.

  Anticancer research 20070101

• Temozolomide and thalidomide in the treatment of glioblastoma multiforme.

  Anticancer research 20070101

• Successful treatment of palmar-plantar erythrodysesthesia possibly due to temozolomide with dexamethasone.

  Journal of postgraduate medicine 20070101

• O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies.

  Molecular cancer 20070101

• Impact of phase II trials with progression-free survival as end-points on survival-based phase III studies in patients with anaplastic gliomas.

  BMC cancer 20070101

• Loss of NOTCH2 positively predicts survival in subgroups of human glial brain tumors.

  PloS one 20070101

• Pulmonary atypical carcinoid tumor with metastatic involvement of the pituitary gland causing functional hypopituitarism.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20070101

• Delirium likely caused by interaction between phenytoin and temozolomide.

  Psychosomatics 20070101

• Standard fractionation intensity modulated radiation therapy (IMRT) of primary and recurrent glioblastoma multiforme.

  Radiation oncology (London, England) 20070101

• Prognostic implication of clinical and pathologic features in patients with glioblastoma multiforme treated with concomitant radiation plus temozolomide.

  Tumori 20070101

• Epidermal growth factor receptor serum levels and prognostic value in malignant gliomas.

  Tumori 20070101

• Medical treatment and other combination regimens.

  Tumori 20070101

• Medical treatment of uveal melanoma.

  Tumori 20070101

• Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocytoma.

  World journal of surgical oncology 20070101

• Combination therapy with thalidomide, temozolomide and tamoxifen improves quality of life in patients with malignant astrocytomas.

  Anticancer research 20070101

• Analysis of long-term survivors of glioblastoma multiforme in a single institution with aggressive local retreatment protocol.

  Anticancer research 20070101

• Clinical impact of adjuvant chemotherapy in glioblastoma multiforme : a meta-analysis.

  CNS drugs 20070101

• Radiotherapeutic alternatives for previously irradiated recurrent gliomas.

  BMC cancer 20070101

• Oblimersen: Augmerosen, BCL-2 antisense oligonucleotide - Genta, G 3139, GC 3139, oblimersen sodium.

  Drugs in R&D 20070101

• Metronomic chemotherapy dosing-schedules with estramustine and temozolomide act synergistically with anti-VEGFR-2 antibody to cause inhibition of human umbilical venous endothelial cell growth.

  Acta oncologica (Stockholm, Sweden) 20070101

• Experimental iodine-125 seed irradiation of intracerebral brain tumors in nude mice.

  Radiation oncology (London, England) 20070101

• Mechanisms operative in the antitumor activity of temozolomide in glioblastoma multiforme.

  Cancer journal (Sudbury, Mass.) 20070101

• Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study.

  Arthritis research & therapy 20070101

• The attitudes of brain cancer patients and their caregivers towards death and dying: a qualitative study.

  BMC palliative care 20070101

• Chemoradiotherapy in high-grade gliomas.

  Tumori 20070101

• Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas.

  Journal of translational medicine 20070101

• Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma.

  Journal of translational medicine 20070101

• A rare case of malignant glioma suspected to have arisen from a cavernous sinus.

  Brain tumor pathology 20070101

• Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer.

  BMC cancer 20070101

• Pegylated liposomal doxorubicin in recurrent malignant glioma: analysis of a case series.

  Oncology 20070101

• Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.

  Oncology 20070101

• [Glioblastomas are resistant to apoptosis but less resistant to the autophagic process].

  Bulletin et memoires de l'Academie royale de medecine de Belgique 20070101

• [Analysis of selected undesirable effects of cytostatic drugs in treatment of the central nervous system tumours in children. Preliminary report].

  Medycyna wieku rozwojowego 20070101

• Targeted brain tumor treatment-current perspectives.

  Drug target insights 20070101

• Therapeutic options for recurrent high-grade glioma in adult patients: recent advances.

  Critical reviews in oncology/hematology 20061201

• Temozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group.

  Annals of oncology : official journal of the European Society for Medical Oncology 20061201

• Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies.

  European journal of cancer (Oxford, England : 1990) 20061201

• Glioblastoma in the elderly: current and future trends.

  Critical reviews in oncology/hematology 20061201

• Potentiation of antiglioma effect with combined temozolomide and interferon-beta.

  Oncology reports 20061201

• Chemotherapy and the treatment of brain metastases.

  Hematology/oncology clinics of North America 20061201

• [Temozolomide in the treatment of recurrent malignant glioma].

  No shinkei geka. Neurological surgery 20061201

• [Individualized chemotherapy based on drug sensitivity and resistance assay and MGMT protein expression for patients with malignant glioma--analysis of 42 cases].

  Ai zheng = Aizheng = Chinese journal of cancer 20061201

• MGMT methylation: a marker of response to temozolomide in low-grade gliomas.

  Annals of neurology 20061201

• [Recent advances in the medical treatment of glioma-temozolomide].

  No to shinkei = Brain and nerve 20061201

• Focus on Fotemustine.

  Journal of experimental & clinical cancer research : CR 20061201

• Gliosarcoma with infratemporal fossa extension. Case report.

  Journal of neurosurgery 20061201

• Multiple gangliogliomas of the optic pathway.

  British journal of neurosurgery 20061201

• New methods for direct delivery of chemotherapy for treating brain tumors.

  The Yale journal of biology and medicine 20061201

• Skin delivery potency and antitumor activities of temozolomide ester prodrugs.

  Cancer letters 20061128

• Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms.

  British journal of cancer 20061120

• Phase II study of temozolomide in relapsed or refractory high-risk neuroblastoma: a joint Société Française des Cancers de l'Enfant and United Kingdom Children Cancer Study Group-New Agents Group Study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061120

• Irinotecan plus temozolomide for relapsed or refractory neuroblastoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061120

• [Gliomas in adults: primary non-surgical treatment].

  Ugeskrift for laeger 20061120

• Chemotherapy for primary central nervous system lymphoma.

  Neurosurgical focus 20061115

• Temozolomide 3 weeks on and 1 week off as first-line therapy for recurrent glioblastoma: phase II study from gruppo italiano cooperativo di neuro-oncologia (GICNO).

  British journal of cancer 20061106

• A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas.

  British journal of cancer 20061106

• Simulating chemotherapeutic schemes in the individualized treatment context: the paradigm of glioblastoma multiforme treated by temozolomide in vivo.

  Computers in biology and medicine 20061101

• Radical surgery after chemotherapy: a new therapeutic strategy to envision in grade II glioma.

  Journal of neuro-oncology 20061101

• In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo.

  Journal of hepatology 20061101

• A pilot study of metronomic temozolomide treatment in patients with recurrent temozolomide-refractory glioblastoma.

  Oncology reports 20061101

• Should concomitant and adjuvant treatment with temozolomide be used as standard therapy in patients with anaplastic glioma?

  Critical reviews in oncology/hematology 20061101

• Chemotherapeutic options for primary brain tumors.

  Current treatment options in oncology 20061101

• Predictive and prognostic markers in human glioblastomas.

  Current treatment options in oncology 20061101

• The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity.

  Molecular cancer therapeutics 20061101

• Glioma therapy in adults.

  The neurologist 20061101

• Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas.

  Expert review of anticancer therapy 20061101

• [Cerebral tumours in the adult. A real increase].

  La Revue du praticien 20061031

• [Pattern of care of high-grade gliomas].

  La Revue du praticien 20061031

• Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs.

  Oncogene 20061026

• Phase II study of temozolomide and thalidomide in patients with metastatic melanoma in the brain: high rate of thromboembolic events (CALGB 500102).

  Cancer 20061015

• Correlations between O6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061010

• Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas.

  British journal of cancer 20061009

• Fatty acid synthase: a novel target for antiglioma therapy.

  British journal of cancer 20061009

• Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status.

  Journal of neuro-oncology 20061001

• Complications of a temozolomide overdose: a case report.

  Journal of neuro-oncology 20061001

• Radiotherapy plus concomitant and adjuvant temozolomide for leptomeningeal pilomyxoid astrocytoma: a case study.

  Journal of neuro-oncology 20061001

• Adding concomitant and adjuvant temozolomide to radiotherapy does not reduce health-related quality of life in people with glioblastoma.

  Cancer treatment reviews 20061001

• Early change in glucose metabolic rate measured using FDG-PET in patients with high-grade glioma predicts response to temozolomide but not temozolomide plus radiotherapy.

  International journal of radiation oncology, biology, physics 20061001

• 1p/19q loss within oligodendroglioma is predictive for response to first line temozolomide but not to salvage treatment.

  European journal of cancer (Oxford, England : 1990) 20061001

• Cerebral blood volume, genotype and chemosensitivity in oligodendroglial tumours.

  Neuroradiology 20061001

• A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system.

  International journal of oncology 20061001

• Antitumour effects of temozolomide in a man with a large, invasive prolactin-producing pituitary neoplasm.

  Clinical endocrinology 20061001

• Dose-intensified bi-weekly temozolomide in patients with asymptomatic brain metastases from malignant melanoma: a phase II DeCOG/ADO study.

  Annals of oncology : official journal of the European Society for Medical Oncology 20061001

• Long-term response of pituitary carcinoma to temozolomide. Report of two cases.

  Journal of neurosurgery 20061001

• Spanish co-operative group of Medical Neuro-oncology (GENOM).

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20061001

• Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060920

• Phase I study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinoma.

  Cancer 20060915

• A phase II study of extended dose temozolomide and thalidomide in previously treated patients with metastatic melanoma.

  Journal of cancer research and clinical oncology 20060901

• Phase II trial of temozolomide and cisplatin followed by whole brain radiotherapy in non-small-cell lung cancer patients with brain metastases: a GLOT-GFPC study.

  Annals of oncology : official journal of the European Society for Medical Oncology 20060901

• Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12.

  Brain : a journal of neurology 20060901

• Temozolomide treatment for newly diagnosed anaplastic oligodendrogliomas: a clinical efficacy trial.

  Journal of neuro-oncology 20060901

• Safety and pharmacokinetics of temozolomide using a dose-escalation, metronomic schedule in recurrent paediatric brain tumours.

  European journal of cancer (Oxford, England : 1990) 20060901

• Radiotherapy and sequential temozolomide compared with radiotherapy with concomitant and sequential temozolomide in the treatment of newly diagnosed glioblastoma multiforme.

  Anti-cancer drugs 20060901

• [Efficacy and safety of monotherapy with temozolomide in patients with anaplastic astrocytoma at first relapse--a phase II clinical study].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060901

• Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line.

  Molecular cancer therapeutics 20060901

• Angiogenesis in cancer.

  Vascular health and risk management 20060901

• Temozolomide as prophylaxis for brain metastasis in non-small cell lung cancer.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20060901

• Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential.

  International journal of nanomedicine 20060901

• Current status of clinical trials for glioblastoma.

  Reviews on recent clinical trials 20060901

• Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide.

  Cancer letters 20060808

• Is protracted low-dose temozolomide feasible in glioma patients?

  Neurology 20060808

• Pro-invasive gene regulating effect of irradiation and combined temozolomide-radiation treatment on surviving human malignant glioma cells.

  European journal of pharmacology 20060807

• Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy.

  Current opinion in pharmacology 20060801

• Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060801

• Alternating chemo-immunotherapy with temozolomide and low-dose interleukin-2 in patients with metastatic melanoma.

  Melanoma research 20060801

• Phase II multicentre study of temozolomide in combination with interferon alpha-2b in metastatic malignant melanoma.

  Melanoma research 20060801

• MR-guided laser-induced interstitial thermotherapy of recurrent glioblastoma multiforme: preliminary results in 16 patients.

  European journal of radiology 20060801

• Temozolomide chemotherapy in patients with recurrent malignant gliomas.

  Journal of Korean medical science 20060801

• Metastatic spinal cord compression: the hidden danger.

  Nature clinical practice. Oncology 20060801

• In vitro drug response and molecular markers associated with drug resistance in malignant gliomas.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060801

• Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060801

• Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060801

• Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress.

  Molecular cancer research : MCR 20060801

• A spatiotemporal, patient individualized simulation model of solid tumor response to chemotherapy in vivo: the paradigm of glioblastoma multiforme treated by temozolomide.

  IEEE transactions on bio-medical engineering 20060801

• Temozolomide: a milestone in neuro-oncology and beyond?

  Expert review of anticancer therapy 20060801

• Cerebral metastases--a therapeutic update.

  Nature clinical practice. Neurology 20060801

• A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.

  British journal of cancer 20060717

• Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177.

  International journal of radiation oncology, biology, physics 20060715

• Temozolomide and oral VP-16 for children and young adults with recurrent or treatment-induced malignant gliomas.

  Pediatric blood & cancer 20060701

• Temozolomide in resistant or relapsed pediatric solid tumors.

  Pediatric blood & cancer 20060701

• Role of temozolomide in pediatric brain tumors.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20060701

• Vinorelbine combined with a protracted course of temozolomide for recurrent brain metastases: a phase I trial.

  Journal of neuro-oncology 20060701

• Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma.

  Neuro-oncology 20060701

• Treatment-related myelodysplasia/AML in a patient with a history of breast cancer and an oligodendroglioma treated with temozolomide: case study and review of the literature.

  Neuro-oncology 20060701

• Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas.

  Oncology reports 20060701

• Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature.

  Surgical neurology 20060701

• [Glioma].

  Nihon rinsho. Japanese journal of clinical medicine 20060701

• Combined biodifferentiating and antiangiogenic oral metronomic therapy is feasible and effective in relapsed solid tumors in children: single-center pilot study.

  Onkologie 20060701

• Overall and progression-free survival in metastatic melanoma: analysis of a single-institution database.

  Cancer control : journal of the Moffitt Cancer Center 20060701

• Temozolomide treatment of refractory epilepsy in a patient with an oligodendroglioma.

  Epilepsia 20060701

• The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice.

  Molecular cancer therapeutics 20060701

• Novel therapeutic approaches in pediatric and young adult sarcomas.

  Current oncology reports 20060701

• Protein expression in experimental malignant glioma varies over time and is altered by radiotherapy treatment.

  British journal of cancer 20060619

• Temozolomide in metastatic breast cancer (MBC): a phase II trial of the National Cancer Institute of Canada - Clinical Trials Group (NCIC-CTG).

  Annals of oncology : official journal of the European Society for Medical Oncology 20060601

• Phase II study of temozolomide plus pegylated interferon-alpha-2b for metastatic melanoma.

  Cancer 20060601

• Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.

  Cancer treatment reviews 20060601

• Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060601

• Temozolomide: a novel treatment for pituitary carcinoma.

  The Lancet. Oncology 20060601

• Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.

  Nature clinical practice. Oncology 20060601

• Gliomatosis cerebri treatment in 11 elderly patients.

  Journal of experimental & clinical cancer research : CR 20060601

• Chemotherapy for malignant gliomas.

  Wiener medizinische Wochenschrift (1946) 20060601

• Re-evaluation of the cost effectiveness of temozolomide for malignant gliomas in British Columbia.

  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20060601

• Autophagy: is it cancer's friend or foe?

  Science (New York, N.Y.) 20060526

• Surgery, radiotherapy and temozolomide in treating high-grade gliomas.

  Frontiers in bioscience : a journal and virtual library 20060501

• Use of 11C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomas.

  European journal of nuclear medicine and molecular imaging 20060501

• Antiangiogenic agent, thalidomide increases the antitumor effect of single high dose irradiation (gamma knife radiosurgery) in the rat orthotopic glioma model.

  Oncology reports 20060501

• Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review).

  International journal of oncology 20060501

• Is current therapy of malignant gliomas beneficial for patients? Proteomics evidence of shifts in glioma cells expression patterns under clinically relevant treatment conditions.

  Proteomics 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Differential effects of HOXB4 on nonhuman primate short- and long-term repopulating cells.

  PLoS medicine 20060501

• Pontine atypical neurocytoma: case report.

  Neurosurgery 20060501

• Aplastic anaemia in patient with glioblastoma multiforme treated with temozolomide.

  The Lancet. Oncology 20060501

• Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275.

  Molecular cancer therapeutics 20060501

• The role of chemotherapy in the treatment of malignant astrocytomas.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20060501

• Present and potential future issues in glioblastoma treatment.

  Expert review of anticancer therapy 20060501

• Cardiac metastasis from uterine leiomyosarcoma.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20060501

• [Phototoxicity of dacarbazine (Deticene) not reinduced by temozolomide (Temodal)].

  Annales de dermatologie et de venereologie 20060501

• Radiation therapy in the management of brain metastases from renal cell carcinoma.

  Oncology (Williston Park, N.Y.) 20060501

• [Temozolomide--a new antitumor preparation in the treatment of central nervous system malignant tumors].

  Georgian medical news 20060501

• Temozolomide for recurrent or progressive high-grade malignant glioma: results of an Austrian multicenter observational study.

  Wiener klinische Wochenschrift 20060501

• The safety of the temozolomide in patients with malignant glioma.

  Current drug safety 20060501

• Epigenetics as a mechanism driving polygenic clinical drug resistance.

  British journal of cancer 20060424

• Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression.

  Cancer 20060415

• A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.

  Cancer research 20060415

• Treatment options for glioblastoma.

  Neurosurgical focus 20060415

• Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.

  Neurosurgical focus 20060415

• Management of malignant glioma: steady progress with multimodal approaches.

  Neurosurgical focus 20060415

• New trends in the medical management of glioblastoma multiforme: the role of temozolomide chemotherapy.

  Neurosurgical focus 20060415

• Autophagy, the Trojan horse to combat glioblastomas.

  Neurosurgical focus 20060415

• Higher dosing of temozolomide? Regression of an anaplastic oligoastrocytoma over more than three years.

  Journal of neuro-oncology 20060401

• O6-(4-bromothenyl)guanine (PaTrin-2), a novel inhibitor of O6-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro.

  Pharmacological research 20060401

• Noninvasive 1H/13C magnetic resonance spectroscopic imaging of the intratumoral distribution of temozolomide.

  Magnetic resonance in medicine 20060401

• Mutagenic potential of temozolomide in bone marrow cells in vivo.

  Blood 20060401

• Altered expression of alpha-dystroglycan subunit in human gliomas.

  Cancer biology & therapy 20060401

• Whole brain irradiation and temozolomide based chemotherapy in melanoma brain metastases.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20060401

• Experimental designs for phase I and phase I/II dose-finding studies.

  British journal of cancer 20060313

• Current strategies in treatment of oligodendroglioma: evolution of molecular signatures of response.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060310

• Recent advances in the treatment of malignant astrocytoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060310

• More from PHARMAC on temozolomide: feedback needed.

  The New Zealand medical journal 20060310

• O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C.

  Toxicology and applied pharmacology 20060301

• Perfusion and diffusion MRI of glioblastoma progression in a four-year prospective temozolomide clinical trial.

  International journal of radiation oncology, biology, physics 20060301

• Phase II trial of temozolomide in children with recurrent high-grade glioma.

  Journal of neuro-oncology 20060301

• Recent developments in the use of chemotherapy in brain tumours.

  European journal of cancer (Oxford, England : 1990) 20060301

• Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060301

• Oral regimen for metastatic neuroendocrine tumours.

  The Lancet. Oncology 20060301

• Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzylguanine.

  Molecular cancer therapeutics 20060301

• [Management of malignant gliomas diagnosed during pregnancy].

  Revue neurologique 20060301

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060301

• Phase II trial of temozolomide and irinotecan as second-line treatment for advanced non-small cell lung cancer.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20060301

• Is protracted low-dose temozolomide feasible in glioma patients?

  Neurology 20060214

• Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children.

  Journal of neuro-oncology 20060201

• Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients.

  Acta neurochirurgica 20060201

• A new approach to modeling covariate effects and individualization in population pharmacokinetics-pharmacodynamics.

  Journal of pharmacokinetics and pharmacodynamics 20060201

• O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.

  Journal of neurochemistry 20060201

• Chemotherapy for glioblastoma multiforme (GBM).

  Surgical neurology 20060201

• Biochemotherapy with temozolomide, cisplatin, vinblastine, subcutaneous interleukin-2 and interferon-alpha in patients with metastatic melanoma.

  Melanoma research 20060201

• A biochemotherapy regimen with concurrent administration of cisplatin, vinblastine, temozolomide (Temodal), interferon-alfa and interleukin-2 for metastatic melanoma: a phase II study.

  Melanoma research 20060201

• A case report of a recurrent intracranial ependymoma treated with temozolomide in remission 10 years after completing chemotherapy.

  American journal of clinical oncology 20060201

• Glioblastoma--more questions than answers?

  Nature clinical practice. Oncology 20060201

• BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060201

• Changing paradigms--an update on the multidisciplinary management of malignant glioma.

  The oncologist 20060201

• Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060120

• Combination of paclitaxel and carboplatin as second-line therapy for patients with metastatic melanoma.

  Cancer 20060115

• Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060110

• Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.

  Journal of the National Cancer Institute 20060104

• Phase II study of temozolomide plus pegylated liposomal doxorubicin in the treatment of brain metastases from solid tumours.

  Cancer chemotherapy and pharmacology 20060101

• The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine.

  The journal of gene medicine 20060101

• Temozolomide with or without radiotherapy in melanoma with unresectable brain metastases.

  Journal of neuro-oncology 20060101

• Phase I study of temozolomide and lomustine in the treatment of high grade malignant glioma.

  Frontiers in bioscience : a journal and virtual library 20060101

• Salvage chemotherapy with cyclophosphamide for recurrent temozolomide-refractory anaplastic astrocytoma.

  Cancer 20060101

• Combination treatment with temozolomide and thalidomide inhibits tumor growth and angiogenesis in an orthotopic glioma model.

  International journal of oncology 20060101

• Combination celecoxib and temozolomide in C6 rat glioma orthotopic model.

  Oncology reports 20060101

• Phase II study of two-weekly temozolomide in patients with high-grade gliomas.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20060101

• Novel radiation-enhancing agents in malignant gliomas.

  Seminars in radiation oncology 20060101

• Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060101

• Gefitinib response of erlotinib-refractory lung cancer involving meninges--role of EGFR mutation.

  Nature clinical practice. Oncology 20060101

• Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.

  Molecular cancer therapeutics 20060101

• Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma.

  Neuro-oncology 20060101

• A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668].

  BMC cancer 20060101

• [Update on cerebral tumors].

  Bulletin du cancer 20060101

• Advances in the treatment of primary brain tumors: dawn of a new era?

  Current oncology reports 20060101

• The evolution of chemoradiation for glioblastoma: a modern success story.

  Current oncology reports 20060101

• Primary malignant melanoma of the lung: a case report and review of the literature.

  Clinical lung cancer 20060101

• Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo.

  Molecular cancer 20060101

• Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol.

  BMC cancer 20060101

• Treatments for astrocytic tumors in children: current and emerging strategies.

  Paediatric drugs 20060101

• Integration of chemotherapy into current treatment strategies for brain metastases from solid tumors.

  Radiation oncology (London, England) 20060101

• High-grade gliomas: results in patients treated with adjuvant radiotherapy alone and with adjuvant radio-chemotherapy.

  Anticancer research 20060101

• Primitive neuroectodermal tumor (PNET) of the brain diagnosed during pregnancy.

  Anticancer research 20060101

• Primary and metastatic brain tumors.

  Forum (Genoa, Italy) 20060101

• PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?

  International journal of medical sciences 20060101

• Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells.

  BMC complementary and alternative medicine 20060101

• In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model.

  BMC cancer 20060101

• Temozolomide and radiotherapy as first-line treatment of high-grade gliomas.

  Tumori 20060101

• Glioblastoma multiforme with oligodendroglial component (GBMO): favorable outcome after post-operative radiotherapy and chemotherapy with nimustine (ACNU) and teniposide (VM26).

  BMC cancer 20060101

• Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.

  Molecular cancer 20060101

• A comparative study on the cost of new antibiotics and drugs of other therapeutic categories.

  PloS one 20060101

• [Results of radical removal of malignant cerebral gliomas, by using computer-assisted navigation, followed by adjuvant therapy].

  Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 20060101

• [Usefulness of the antisense and triplex anti-IGF-1 techniques for postoperative cellular gene therapy of malignant gliomas expressing IGF-1].

  Neurologia i neurochirurgia polska 20060101

• A phase II clinical study on relapsed malignant gliomas treated with electro-hyperthermia.

  In vivo (Athens, Greece) 20060101

• Post-operative combined radiation and chemotherapy with temozolomide and irinotecan in patients with high-grade astrocytic tumors. A phase II study with biomarker evaluation.

  Anticancer research 20060101

• Extensive local and systemic therapy in extraneural metastasized glioblastoma multiforme.

  Anticancer research 20060101

• Concomitant radiochemotherapy with temozolomide in non-selected patients with newly diagnosed high-grade gliomas.

  Anticancer research 20060101

• Phase II Trial of Doxorubicin Plus Escalated High-Dose Ifosfamide in Patients With Advanced Soft Tissue Sarcomas of the Adult: A Study of the Spanish Group for Research on Sarcomas (GEIS).

  Sarcoma 20060101

• [Chemotherapy registry quality in Andalusian hospital pharmacy departments].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20060101

• [Treatment results of children and adolescents with brain stem tumours. Own experiences].

  Medycyna wieku rozwojowego 20060101

• Oncolytic herpes simplex virus mutants exhibit enhanced replication in glioma cells evading temozolomide chemotherapy through deoxyribonucleic acid repair.

  Clinical neurosurgery 20060101

• Brain metastasis--evidence based management.

  Journal of cancer research and therapeutics 20060101

• Combined modality treatment of glioblastoma multiforme: the role of temozolomide.

  Reviews on recent clinical trials 20060101

• Spotlight on cancer informatics.

  Cancer informatics 20060101

• Applying a 4D multiscale in vivo tumor growth model to the exploration of radiotherapy scheduling: the effects of weekend treatment gaps and p53 gene status on the response of fast growing solid tumors.

  Cancer informatics 20060101

• Predictive utility of circulating methylated DNA in serum of melanoma patients receiving biochemotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051220

• Evidence, economics, and emotions: the case for temozolomide.

  The New Zealand medical journal 20051216

• PHARMAC's response on temozolomide and funding costly medicines that prolong life shortly.

  The New Zealand medical journal 20051216

• Low-dose outpatient chemobiotherapy with temozolomide, granulocyte-macrophage colony stimulating factor, interferon-alpha2b, and recombinant interleukin-2 for the treatment of metastatic melanoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051210

• Temozolomide in combination with interferon-alfa versus temozolomide alone in patients with advanced metastatic melanoma: a randomized, phase III, multicenter study from the Dermatologic Cooperative Oncology Group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051210

• The treatment of high grade gliomas and diffuse intrinsic pontine tumors of childhood and adolescence: a historical - and futuristic - perspective.

  Journal of neuro-oncology 20051201

• Salvage temozolomide for prior temozolomide responders.

  Cancer 20051201

• Treatment of astrocytomas.

  Current opinion in neurology 20051201

• Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide.

  European journal of cancer (Oxford, England : 1990) 20051201

• Temozolomide in combination with cisplatin in patients with metastatic melanoma: a phase II trial.

  Melanoma research 20051201

• Health-related quality of life in patients with glioblastoma: a randomised controlled trial.

  The Lancet. Oncology 20051201

• Temozolomide in the treatment of recurrent malignant glioma in Chinese patients.

  Hong Kong medical journal = Xianggang yi xue za zhi 20051201

• Hematopoietic stem cell transduction and amplification in large animal models.

  Human gene therapy 20051201

• [Concomitant radiotherapy with chemotherapy in patients with glioblastoma].

  Bulletin du cancer 20051201

• Extended continuous oral temozolomide in patients with progressive metastatic renal cell carcinoma not responding to interferon alpha 2b.

  Journal of chemotherapy (Florence, Italy) 20051201

• Temozolomide: a milestone in the pharmacotherapy of brain tumors.

  Future oncology (London, England) 20051201

• Drug Insight: temozolomide as a treatment for malignant glioma--impact of a recent trial.

  Nature clinical practice. Neurology 20051201

• Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase.

  Cancer research 20051115

• O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.

  British journal of cancer 20051114

• Relapse of primary CNS lymphoma after more than 10 years in complete remission.

  Journal of neurology 20051101

• Oral temozolomide in heavily pre-treated brain metastases from non-small cell lung cancer: phase II study.

  Lung cancer (Amsterdam, Netherlands) 20051101

• Postoperative radiotherapy and chemotherapy in the management of oligodendroglioma: single institutional review of 88 patients.

  Journal of neuro-oncology 20051101

• A Phase I trial of protracted oral fixed-dose temozolomide.

  Cancer 20051101

• Organ- and treatment-specific local response rates to systemic and local treatment modalities in stage IV melanoma.

  The British journal of dermatology 20051101

• Current strategies in whole-brain radiation therapy for brain metastases.

  Neurosurgery 20051101

• Chemotherapy in brain metastases.

  Neurosurgery 20051101

• Current treatment paradigms for the management of patients with brain metastases.

  Neurosurgery 20051101

• Adding temozolomide to radiotherapy prolongs survival in people with glioblastoma.

  Cancer treatment reviews 20051101

• Avoiding glucocorticoid administration in a neurooncological case.

  Cancer biology & therapy 20051101

• Emerging targeted treatments for malignant glioma.

  Expert opinion on emerging drugs 20051101

• Systemic temozolomide combined with loco-regional mitoxantrone in treating recurrent glioblastoma.

  Journal of neuro-oncology 20051101

• 10 questions about temozolomide and the treatment of brain tumors.

  The neurologist 20051101

• A congenital brain tumor associated with assisted in vitro fertilization. Case report.

  Journal of neurosurgery 20051101

• Phase I study of O6-benzylguanine and temozolomide administered daily for 5 days to pediatric patients with solid tumors.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051020

• A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: a study by the Spanish Group for Research on Sarcomas.

  Cancer 20051015

• Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051015

• [Standards and new developments in the chemotherapy of glioblastomas].

  Deutsche medizinische Wochenschrift (1946) 20051007

• Secondary Ph+ acute lymphoblastic leukemia after temozolomide.

  Annals of hematology 20051001

• Phase I trial of irinotecan plus temozolomide in adults with recurrent malignant glioma.

  Cancer 20051001

• Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy.

  International journal of radiation oncology, biology, physics 20051001

• Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051001

• A low rate of central nervous system progression in a phase II trial of outpatient chemobiologic therapy with cisplatin, temozolomide, interleukin-2, and interferon alfa 2-B for metastatic malignant melanoma.

  American journal of clinical oncology 20051001

• Food and Drug Administration Drug approval summary: temozolomide plus radiation therapy for the treatment of newly diagnosed glioblastoma multiforme.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

• Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment.

  Neoplasia (New York, N.Y.) 20051001

• A retrospective study of biochemotherapy for metastatic melanoma: the importance of dose intensity.

  Cancer biotherapy & radiopharmaceuticals 20051001

• Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies.

  British journal of cancer 20050905

• Recent advances in conventional-dose salvage chemotherapy in patients with cisplatin-resistant or refractory testicular germ cell tumors.

  European urology 20050901

• [Radiotherapy for glioblastomas: from radiobiology to concomitant chemotherapy].

  Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20050901

• IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide.

  Cancer research 20050901

• Phase II trial of temozolomide in patients with pretreated cutaneous T-cell lymphoma.

  Haematologica 20050901

• Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma.

  Molecular cancer therapeutics 20050901

• Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.

  Molecular cancer therapeutics 20050901

• Inactivation of p53 sensitizes astrocytic glioma cells to BCNU and temozolomide, but not cisplatin.

  Journal of neuro-oncology 20050901

• [Role of extracellular matrix degradation enzyme for glioma invasion].

  Nihon rinsho. Japanese journal of clinical medicine 20050901

• [Chemotherapy for gliomas in children].

  Nihon rinsho. Japanese journal of clinical medicine 20050901

• [Treatment of malignant gliomas in the elderly].

  Nihon rinsho. Japanese journal of clinical medicine 20050901

• [Chemotherapy for brain metastases].

  Nihon rinsho. Japanese journal of clinical medicine 20050901

• The role of chemotherapy in the treatment of low-grade glioma. A review of the literature.

  Acta neurologica Belgica 20050901

• Efficiency, quality and bureaucracy: not always in the same bag!!

  European journal of cancer (Oxford, England : 1990) 20050901

• Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide.

  International journal of cancer 20050820

• Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo.

  Cancer research 20050815

• Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy.

  Oncogene 20050804

• Generation of an immortalized human endothelial cell line as a model of neovascular proliferating endothelial cells to assess chemosensitivity to anticancer drugs.

  International journal of oncology 20050801

• Brain metastases in metastatic non-small cell lung cancer responding to single-agent gefitinib: a case report.

  Anti-cancer drugs 20050801

• Cardiac metastasis of melanoma.

  Melanoma research 20050801

• Osseous metastasis of pineoblastoma: a case report and review of the literature.

  Journal of neuro-oncology 20050801

• Gliosarcomas: analysis of 11 cases do two subtypes exist?

  Journal of neuro-oncology 20050801

• HER1/EGFR tyrosine kinase inhibitors for the treatment of glioblastoma multiforme.

  Journal of neuro-oncology 20050801

• Author comments on drug-dispensing change.

  Clinical journal of oncology nursing 20050801

• [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle].

  Wiener medizinische Wochenschrift (1946) 20050801

• The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death.

  Cancer research 20050715

• Low-grade primary meningeal lymphoma: case report and review of the literature.

  Neurosurgical review 20050701

• Temozolomide in combination with BCNU before and after radiotherapy in patients with inoperable newly diagnosed glioblastoma multiforme.

  Annals of oncology : official journal of the European Society for Medical Oncology 20050701

• Chemopotentiation by PARP inhibitors in cancer therapy.

  Pharmacological research 20050701

• Clinical perspectives of PARP inhibitors.

  Pharmacological research 20050701

• Temozolomide in uterine leiomyosarcomas.

  Gynecologic oncology 20050701

• Artificial tumor model suitable for monitoring 31P and 13C NMR spectroscopic changes during chemotherapy-induced apoptosis in human glioma cells.

  Magnetic resonance in medicine 20050701

• Temozolomide-induced partial response in a patient with primary diffuse leptomeningeal gliomatosis.

  Journal of neuro-oncology 20050701

• Radiotherapy plus adjuvant temozolomide for the treatment of glioblastoma--a paradigm shift.

  Nature clinical practice. Oncology 20050701

• Use of magnetic resonance imaging to assess blood-brain/blood-glioma barrier opening during conformal radiotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050620

• How lymphotoxic is dose-intensified temozolomide? The glioblastoma experience.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050620

• [Temozolomide in patients with a glioblastoma multiforme: new developments].

  Nederlands tijdschrift voor geneeskunde 20050618

• [Favourable result for temozolomide in recurrent high-grade glioma].

  Nederlands tijdschrift voor geneeskunde 20050618

• Temozolomide plus thalidomide in patients with brain metastases from melanoma: a phase II study.

  Cancer 20050615

• Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib.

  Journal of the National Cancer Institute 20050615

• Treatment of brain tumors.

  The New England journal of medicine 20050602

• Treatment of brain tumors.

  The New England journal of medicine 20050602

• Management of pilocytic astrocytoma with diffuse leptomeningeal spread: two cases and review of the literature.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20050601

• Temozolomide and cisplatin versus temozolomide in patients with advanced melanoma: a randomized phase II study of the Hellenic Cooperative Oncology Group.

  Annals of oncology : official journal of the European Society for Medical Oncology 20050601

• Engineering 3-alkyltriazenes to block bcr-abl kinase: a novel strategy for the therapy of advanced bcr-abl expressing leukemias.

  Leukemia research 20050601

• Neoadjuvant phase II multicentre study of new agents in patients with malignant glioma after minimal surgery. Report of a cohort of 187 patients treated with temozolomide.

  Annals of oncology : official journal of the European Society for Medical Oncology 20050601

• Temozolomide combined with irradiation as postoperative treatment of primary glioblastoma multiforme. Phase I/II study.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20050601

• Role of novel targeted therapies in the clinic.

  British journal of cancer 20050601

• Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence.

  Cancer research 20050601

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Maintenance of fertility following treatment with temozolomide for a high grade astrocytoma.

  Journal of neuro-oncology 20050601

• Modeling antitumor activity in xenograft tumor treatment.

  Biometrical journal. Biometrische Zeitschrift 20050601

• Effects of cisplatin on olfactory function in cancer patients.

  British journal of cancer 20050509

• Development of a pharmacokinetic limited sampling model for temozolomide and its active metabolite MTIC.

  Cancer chemotherapy and pharmacology 20050501

• Treatment of brain metastases from melanoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050501

• Concomitant chemoradiotherapy followed by adjuvant temozolomide improves survival in glioblastoma multiforme.

  Current neurology and neuroscience reports 20050501

• Optimal role of temozolomide in the treatment of malignant gliomas.

  Current neurology and neuroscience reports 20050501

• Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050501

• Treatment of metastatic malignant melanoma.

  Current treatment options in oncology 20050501

• Local drug delivery in recurrent malignant gliomas.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20050501

• Temozolomide and radiation for aggressive pediatric central nervous system malignancies.

  Journal of pediatric hematology/oncology 20050501

• P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy.

  Journal of neuro-oncology 20050501

• Can a rational design for metronomic chemotherapy dosing be devised?

  British journal of cancer 20050425

• Dexamethasone decreases temozolomide-induced apoptosis in human gliobastoma T98G cells.

  Glia 20050415

• Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.

  Cancer research 20050415

• Cerebrospinal fluid-disseminated meningioma.

  Cancer 20050401

• Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050401

• O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050401

• A phase II study of concurrent temozolomide and cis-retinoic acid with radiation for adult patients with newly diagnosed supratentorial glioblastoma.

  International journal of radiation oncology, biology, physics 20050401

• Cost of temozolomide therapy and global care for recurrent malignant gliomas followed until death.

  Neuro-oncology 20050401

• Adjuvant chemotherapy in the treatment of high grade gliomas.

  Cancer treatment reviews 20050401

• [Highly quality-controlled radiation therapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050401

• Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts.

  Journal of neurosurgery 20050401

• [New place of the chemotherapy in gliomas].

  Bulletin du cancer 20050401

• Does addition of temozolomide to whole brain radiotherapy improve outcome in patients with brain metastases?

  Nature clinical practice. Oncology 20050401

• Phase I study of temozolomide plus paclitaxel in patients with advanced malignant melanoma and associated in vitro investigations.

  British journal of cancer 20050328

• PARP inhibitors for cancer therapy.

  Expert reviews in molecular medicine 20050315

• Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

  The New England journal of medicine 20050310

• MGMT gene silencing and benefit from temozolomide in glioblastoma.

  The New England journal of medicine 20050310

• Chemotherapy for brain tumors--a new beginning.

  The New England journal of medicine 20050310

• Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide.

  Neurology 20050308

• Temozolomide in the treatment of solid tumours: current results and rationale for dosing/scheduling.

  Critical reviews in oncology/hematology 20050301

• Expression of ABC-1 transporter is elevated in human glioma cells under irradiation and temozolomide treatment.

  Amino acids 20050301

• Efficacy and toxicity of postoperative temozolomide radiochemotherapy in malignant glioma.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20050301

• Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy.

  Blood 20050201

• Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors.

  International journal of oncology 20050201

• Normal values of serum S-100B predict prolonged survival for stage IV melanoma patients.

  European journal of cancer (Oxford, England : 1990) 20050201

• Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma.

  Journal of neuro-oncology 20050201

• Successful treatment of a chemoresistant tumor with temozolomide in an adult patient: report of a recurrent intracranial mesenchymal chondrosarcoma.

  Journal of neuro-oncology 20050201

• [Gliomatosis cerebri].

  Revue neurologique 20050201

• The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors.

  Bioorganic & medicinal chemistry letters 20050117

• Repeated-measures models with constrained parameters for incomplete data in tumour xenograft experiments.

  Statistics in medicine 20050115

• Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme.

  Journal of cancer research and clinical oncology 20050101

• Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98).

  Cancer 20050101

• Neuro-oncology: the growing role of chemotherapy in glioma.

  The Lancet. Neurology 20050101

• Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial.

  International journal of radiation oncology, biology, physics 20050101

• Research news and notes.

  Surgical neurology 20050101

• Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: case study.

  Neuro-oncology 20050101

• Temozolomide (TMZ) combined with cisplatin (CDDP) in patients with brain metastases from solid tumors: a Hellenic Cooperative Oncology Group (HeCOG) Phase II study.

  Journal of neuro-oncology 20050101

• Cerebral metastases of malignant melanoma: contemporary treatment modalities and survival outcome.

  Neoplasma 20050101

• Clinical practice guideline on the optimal radiotherapeutic management of brain metastases.

  BMC cancer 20050101

• Response to temozolomide in second-line treatment of recurrent nonsmall cell lung carcinoma: case report.

  Cancer investigation 20050101

• Benefit of temozolomide compared to procarbazine in treatment of glioblastoma multiforme at first relapse: effect on neurological functioning, performance status, and health related quality of life.

  Cancer investigation 20050101

• Temozolomide and cisplatin in avdanced malignant melanoma.

  Anticancer research 20050101

• Hypofractionated stereotactic re-irradiation: treatment option in recurrent malignant glioma.

  BMC cancer 20050101

• Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma.

  Medical hypotheses 20050101

• Cancer cell adaptation to chemotherapy.

  BMC cancer 20050101

• Economic evaluation of temozolomide in the treatment of recurrent glioblastoma multiforme.

  PharmacoEconomics 20050101

• A phase II study of biochemotherapy for advanced melanoma incorporating temozolomide, decrescendo interleukin-2 and GM-CSF.

  Cancer investigation 20050101

• Disseminated primary diffuse leptomeningeal gliomatosis: a case report with liquid based and conventional smear cytology.

  CytoJournal 20050101

• Targeting energy metabolism in brain cancer: review and hypothesis.

  Nutrition & metabolism 20050101

• Epigenetics of cervical cancer. An overview and therapeutic perspectives.

  Molecular cancer 20050101

• New drug extends lives of brain cancer patients.

  FDA consumer 20050101

• Long-term disease-free survival in advanced melanomas treated with nitrosoureas: mechanisms and new perspectives.

  BMC cancer 20050101

• Treatment of unresectable glioblastoma multiforme.

  Anticancer research 20050101

• Glioblastoma multiforme treated by the chemotherapeutic agent temozolomide in vivo: a 4D simulation model of the tumor response.

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20050101

• Synthesis and antitumor activity of methyltriazene prodrugs simultaneously releasing DNA-methylating agents and the antiresistance drug O(6)-benzylguanine.

  Journal of medicinal chemistry 20041230

• Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly population.

  Cancer 20041215

• Immunochemotherapy with rituximab and temozolomide for central nervous system lymphomas.

  Cancer 20041215

• The combi-targeting concept: dissection of the binary mechanism of action of the combi-triazene SMA41 in vitro and antitumor activity in vivo.

  The Journal of pharmacology and experimental therapeutics 20041201

• Advances in the biology and treatment of oligodendrogliomas.

  Current opinion in neurology 20041201

• The piperidine nitroxide Tempol potentiates the cytotoxic effects of temozolomide in human glioblastoma cells.

  International journal of oncology 20041201

• Second-line chemotherapy with irinotecan plus carmustine in glioblastoma recurrent or progressive after first-line temozolomide chemotherapy: a phase II study of the Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20041201

• Biochemotherapy in patients with advanced vulvovaginal mucosal melanoma.

  Melanoma research 20041201

• Pharmacokinetic model-predicted anticancer drug concentrations in human tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041201

• Response of low-grade oligodendroglial tumors to temozolomide.

  Journal of neuro-oncology 20041201

• Phase II study of temozolomide and cisplatin as primary treatment prior to radiotherapy in newly diagnosed glioblastoma multiforme patients with measurable disease. A study of the Spanish Medical Neuro-Oncology Group (GENOM).

  Journal of neuro-oncology 20041201

• Temozolomide chemotherapy of patients with recurrent anaplastic astrocytomas and glioblastomas.

  Ideggyogyaszati szemle 20041120

• Alkylation damage in DNA and RNA--repair mechanisms and medical significance.

  DNA repair 20041102

• Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with nonconjugated inhibitors and effect on fotemustine and temozolomide-induced cell death.

  The Journal of pharmacology and experimental therapeutics 20041101

• Recurrent spinal ependymoma showing partial remission under Imatimib.

  Acta neurochirurgica 20041101

• Can we afford to add chemotherapy to radiotherapy for glioblastoma multiforme? Cost-identification analysis of concomitant and adjuvant treatment with temozolomide until patient death.

  Cancer 20041101

• Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study.

  British journal of cancer 20041101

• Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4.

  Molecular therapy : the journal of the American Society of Gene Therapy 20041101

• Temozolomide is a novel regional infusion agent for the treatment of advanced extremity melanoma.

  American journal of surgery 20041101

• Hierarchical models for tumor xenograft experiments in drug development.

  Journal of biopharmaceutical statistics 20041101

• Making inferences about projected completors in longitudinal studies.

  Journal of biopharmaceutical statistics 20041101

• Recent advances in primary CNS lymphoma.

  Current opinion in oncology 20041101

• Innovative therapy for patients with brain metastases: oral treatments.

  Journal of chemotherapy (Florence, Italy) 20041101

• How effective is BCNU in recurrent glioblastoma in the modern era? A phase II trial.

  Neurology 20041012

• Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme.

  International journal of radiation oncology, biology, physics 20041001

• The role of taxanes in the treatment of metastatic melanoma.

  Melanoma research 20041001

• Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft model.

  Cancer research 20041001

• Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase.

  Molecular cancer therapeutics 20041001

• Diagnosis and management of oligodendroglioma.

  Seminars in oncology 20041001

• Temozolomide for the treatment of recurrent supratentorial glioma: results of a compassionate use program in Belgium.

  Journal of neuro-oncology 20041001

• Intracranial metastatic esthesioneuroblastoma responsive to temozolomide.

  Journal of neuro-oncology 20041001

• Phase II study of concurrent continuous Temozolomide (TMZ) and Tamoxifen (TMX) for recurrent malignant astrocytic gliomas.

  Journal of neuro-oncology 20041001

• New (1-deaza)purine derivatives via efficient C-2 nitration of the (1-deaza)purine ring.

  Nucleosides, nucleotides & nucleic acids 20041001

• Management of metastatic cutaneous melanoma.

  Oncology (Williston Park, N.Y.) 20041001

• Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma.

  Cancer research 20040915

• Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide.

  Neurology 20040914

• Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas.

  Neurology 20040914

• Phase II trial of carboplatin and etoposide for patients with recurrent high-grade glioma.

  British journal of cancer 20040913

• Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.

  British journal of cancer 20040913

• Sustained antiproliferative mechanisms by RB24, a targeted precursor of multiple inhibitors of epidermal growth factor receptor and a DNA alkylating agent in the A431 epidermal carcinoma of the vulva cell line.

  British journal of cancer 20040913

• Treatment of advanced melanoma with temozolomide: I.

  Current oncology reports 20040901

• Treatment of advanced melanoma with temozolomide: II.

  Current oncology reports 20040901

• DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system.

  Molecular pharmacology 20040901

• Combined treatment of glioblastoma patients with locoregional pre-targeted 90Y-biotin radioimmunotherapy and temozolomide.

  The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... 20040901

• Current therapies for glioblastoma.

  Clinical advances in hematology & oncology : H&O 20040901

• A prognostic index that predicts outcome following palliative whole brain radiotherapy for patients with metastatic malignant melanoma.

  British journal of cancer 20040831

• Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.

  Neurology 20040810

• Temozolomide in paediatric high-grade glioma: a key for combination therapy?

  British journal of cancer 20040802

• Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040801

• CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040801

• Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.

  Molecular cancer therapeutics 20040801

• The effect of temozolomide-based chemotherapy in patients with cerebral metastases from melanoma.

  Melanoma research 20040801

• Temozolomide and interferon-alpha in metastatic melanoma: a phase II study of the Italian Melanoma Intergroup.

  Melanoma research 20040801

• Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide.

  Human gene therapy 20040801

• Gliomatosis cerebri: better definition, better treatment.

  Neurology 20040727

• Initial chemotherapy in gliomatosis cerebri.

  Neurology 20040727

• Chemotherapy as initial treatment in gliomatosis cerebri: results with temozolomide.

  Neurology 20040727

• Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors.

  International journal of radiation oncology, biology, physics 20040715

• Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma.

  Cancer research 20040715

• Immunochemotherapy with rituximab and temozolomide for central nervous system lymphomas.

  Cancer 20040701

• Distinct responses of xenografted gliomas to different alkylating agents are related to histology and genetic alterations.

  Cancer research 20040701

• Immediate postoperative radiotherapy or 'watch and wait' in the management of adult low-grade glioma?

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20040701

• Salvage chemotherapy with temozolomide in primary CNS lymphomas: preliminary results of a phase II trial.

  European journal of cancer (Oxford, England : 1990) 20040701

• Quality assurance of the EORTC 26981/22981; NCIC CE3 intergroup trial on radiotherapy with or without temozolomide for newly-diagnosed glioblastoma multiforme: the individual case review.

  European journal of cancer (Oxford, England : 1990) 20040701

• Temozolomide and interferon alpha 2b in metastatic melanoma stage IV.

  The British journal of dermatology 20040701

• Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.

  Neuro-oncology 20040701

• One week on/one week off: a novel active regimen of temozolomide for recurrent glioblastoma.

  Neurology 20040608

• Prolonged schedule of temozolomide (Temodal) plus liposomal doxorubicin (Caelyx) in advanced solid cancers.

  Anti-cancer drugs 20040601

• Temozolomide for the treatment of brain metastases associated with metastatic melanoma: a phase II study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040601

• Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040601

• In vitro antitumour activity of resveratrol in human melanoma cells sensitive or resistant to temozolomide.

  Melanoma research 20040601

• A phase II evaluation of Temozolomide in patients with recurrent epithelial ovarian cancer.

  Gynecologic oncology 20040601

• Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide.

  Journal of neurosurgery 20040601

• Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway.

  Current opinion in investigational drugs (London, England : 2000) 20040601

• Current and future trials of the EORTC brain tumor group.

  Onkologie 20040601

• Evaluation of temozolomide in patients with myelodysplastic syndrome.

  Leukemia & lymphoma 20040601

• Long-term outcome of oligodendrogliomas.

  Neurology 20040525

• Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.

  Bioorganic & medicinal chemistry letters 20040517

• Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations.

  Cancer 20040515

• Modeling antitumor activity by using a non-linear mixed-effects model.

  Mathematical biosciences 20040501

• BCNU as second line therapy for recurrent high-grade glioma previously treated with Temozolomide.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20040501

• Dacarbazine but not temozolomide induces phototoxic dermatitis in patients with malignant melanoma.

  Journal of the American Academy of Dermatology 20040501

• First-line chemotherapy with cisplatin plus fractionated temozolomide in recurrent glioblastoma multiforme: a phase II study of the Gruppo Italiano Cooperativo di Neuro-Oncologia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040501

• Irinotecan-induced interstitial pneumonia.

  The Lancet. Oncology 20040501

• Ifosfamide/carboplatin/etoposide (ICE) as front-line, topotecan/cyclophosphamide as second-line and oral temozolomide as third-line treatment for advanced neuroblastoma over one year of age.

  Acta paediatrica (Oslo, Norway : 1992). Supplement 20040501

• Transient local response and persistent tumor control in a child with recurrent malignant glioma: treatment with combination therapy including dendritic cell therapy. Case report.

  Journal of neurosurgery 20040501

• Disposition and pharmacokinetics of temozolomide in rat.

  Xenobiotica; the fate of foreign compounds in biological systems 20040501

• Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma: a North American Brain Tumor Consortium Trial.

  Cancer 20040415

• Temozolomide for treatment-resistant recurrent meningioma.

  Neurology 20040413

• Unusual and severe symptomatic impairment of neutrophil function after one cycle of temozolomide in patients with malignant glioma.

  Annals of hematology 20040401

• Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells.

  Cell death and differentiation 20040401

• Phase II trial of temozolomide in patients with cisplatin-refractory germ cell tumors.

  Investigational new drugs 20040401

• Biochemotherapy in patients with metastatic anorectal mucosal melanoma.

  Cancer 20040401

• Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors. Case report with histological and molecular differentiation of the tumors and review of the literature.

  Journal of neurosurgery 20040401

• Survival and prognostic factors in patients with brain metastases from malignant melanoma.

  Onkologie 20040401

• Complete response of multiple melanoma brain metastases after treatment with temozolomide.

  Onkologie 20040401

• [Survival analysis following the addition of temozolomide to surgery and radiotherapy in patients with glioblastoma multiforme].

  Neurocirugia (Asturias, Spain) 20040401

• [Temozolomide in patients with melanoma brain metastases treated with whole brain irradiation].

  Medicina clinica 20040327

• Salvage chemotherapy with cyclophosphamide for recurrent, temozolomide-refractory glioblastoma multiforme.

  Cancer 20040315

• Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040315

• Primary cultures of microglial cells for testing toxicity of anticancer drugs.

  Toxicology letters 20040314

• Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1.

  British journal of pharmacology 20040301

• A randomized phase I and pharmacological trial of sequences of 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide in patients with advanced solid neoplasms.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040301

• Management of brain metastases in patients with melanoma.

  Current opinion in oncology 20040301

• Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy.

  British journal of cancer 20040223

• Selective CD4+ lymphopenia in melanoma patients treated with temozolomide: a toxicity with therapeutic implications.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040215

• Temozolomide for melanoma: new toxicities and new opportunities.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040215

• Temozolomide in the treatment of recurrent malignant glioma.

  Cancer 20040201

• Temozolomide in combination with irinotecan for treatment of recurrent malignant glioma.

  American journal of clinical oncology 20040201

• Phase I trial of temozolomide and protracted irinotecan in pediatric patients with refractory solid tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040201

• Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040201

• Dual repair modulation reverses Temozolomide resistance in vitro.

  Molecular cancer therapeutics 20040201

• Metastatic malignant melanoma presenting as a cavernous sinus syndrome.

  Journal of neurology 20040201

• Chemotherapy of anaplastic oligodendroglial tumours.

  Expert opinion on pharmacotherapy 20040201

• Bony metastases of anaplastic oligodendroglioma respond to temozolomide.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20040201

• [Therapy of malignant melanoma at the stage of distant metastasis].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20040201

• Temozolomide as prophylaxis for melanoma brain metastases.

  Melanoma research 20040201

• Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

  Oncogene 20040115

• Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.

  Oncogene 20040108

• Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

  Journal of the National Cancer Institute 20040107

• Dose-dense regimen of temozolomide given every other week in patients with primary central nervous system tumors.

  Annals of oncology : official journal of the European Society for Medical Oncology 20040101

• Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers.

  Investigational new drugs 20040101

• Temozolomide in patients with advanced cancer: phase I and pharmacokinetic study.

  Pharmacotherapy 20040101

• Volume of residual disease as a predictor of outcome in adult patients with recurrent supratentorial glioblastomas multiforme who are undergoing chemotherapy.

  Journal of neurosurgery 20040101

• The role of topotecan in the treatment of brain metastases.

  The oncologist 20040101

• Phase 2 study of BCNU and temozolomide for recurrent glioblastoma multiforme: North American Brain Tumor Consortium study.

  Neuro-oncology 20040101

• Phase 2 study of temozolomide and Caelyx in patients with recurrent glioblastoma multiforme.

  Neuro-oncology 20040101

• A phase II trial of temozolomide and IFN-alpha in patients with advanced renal cell carcinoma.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20040101

• Phase II trial of cisplatin plus temozolomide, in recurrent and progressive malignant glioma patients.

  Journal of neuro-oncology 20040101

• Temozolomide as first-line agent in treating high-grade gliomas: phase II study.

  Journal of neuro-oncology 20040101

• Combined thalidomide and temozolomide treatment in patients with glioblastoma multiforme.

  Journal of neuro-oncology 20040101

• The effect of sequential radiochemotherapy in preirradiated malignant gliomas in a phase II study.

  Journal of neuro-oncology 20040101

• Effect of association of temozolomide with other chemotherapic agents on cell growth inhibition in glioma cell lines.

  Oncology research 20040101

• Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone.

  Anticancer research 20040101

• Temozolomide treatment in glioma--experiences in two university hospitals in Finland.

  Acta oncologica (Stockholm, Sweden) 20040101

• Role of DNA mismatch repair in apoptotic responses to therapeutic agents.

  Environmental and molecular mutagenesis 20040101

• Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities.

  Molecular cancer 20040101

• Clinical response following adjuvant Temozolomide in a patient with primary cerebral lymphoma.

  Anticancer research 20040101

• A two-arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas.

  Cancer 20031215

• Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors.

  Cancer chemotherapy and pharmacology 20031201

• Pharmacokinetics of temozolomide given three times a day in pediatric and adult patients.

  Cancer chemotherapy and pharmacology 20031201

• Response to low dose temozolomide in radiation induced gliomatosis cerebri.

  Medical and pediatric oncology 20031201

• Promises and controversies in the management of low-grade glioma.

  Annals of oncology : official journal of the European Society for Medical Oncology 20031201

• Phase II study of primary temozolomide chemotherapy in patients with WHO grade II gliomas.

  Annals of oncology : official journal of the European Society for Medical Oncology 20031201

• Temozolomide chemotherapy for progressive low-grade glioma: clinical benefits and radiological response.

  Annals of oncology : official journal of the European Society for Medical Oncology 20031201

• Carboplatin and teniposide as third-line chemotherapy in patients with recurrent oligodendroglioma or oligoastrocytoma: a phase II study.

  Annals of oncology : official journal of the European Society for Medical Oncology 20031201

• Novel chemotherapeutic agents for the treatment of glioblastoma multiforme.

  Expert opinion on investigational drugs 20031201

• Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines.

  British journal of cancer 20031201

• Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide.

  Journal of neurosurgery 20031201

• State-of-the-art treatment of high-grade brain tumors.

  Seminars in oncology 20031201

• Benefits of adjuvant chemotherapy in high-grade gliomas.

  Seminars in oncology 20031201

• Can chemotherapy replace radiotherapy in low-grade gliomas? Time for randomized studies.

  Seminars in oncology 20031201

• The treatment of elderly patients with high-grade gliomas.

  Seminars in oncology 20031201

• Should radiotherapy be standard therapy for brain tumors in the elderly? Cons.

  Seminars in oncology 20031201

• The European Organisation for Research and Treatment of Cancer strategy for new drug development in brain tumors.

  Seminars in oncology 20031201

• New approach in delivering chemotherapy: locoregional treatment for recurrent glioblastoma (rGBM).

  Journal of experimental & clinical cancer research : CR 20031201

• A phase I (tumour site-specific) study of carboplatin and temozolomide in patients with advanced melanoma.

  British journal of cancer 20031117

• Phase II trial of intralesional therapy with interleukin-2 in soft-tissue melanoma metastases.

  British journal of cancer 20031103

• A mechanistic mathematical model of temozolomide myelosuppression in children with high-grade gliomas.

  Mathematical biosciences 20031101

• Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis.

  Surgical neurology 20031101

• A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma.

  Cancer 20031101

• Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20031101

• Temozolomide: realizing the promise and potential.

  Current opinion in oncology 20031101

• Gliomatosis cerebri: clinical, neurochemical and neuroradiological response to temozolomide administration.

  Magnetic resonance imaging 20031101

• Bibliography. Current world literature. Therapeutic modalities.

  Current opinion in oncology 20031101

• O6-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma.

  British journal of cancer 20031020

• MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine.

  Oncogene 20031016

• Response of recurrent anaplastic ependymoma to a combination of tamoxifen and isotretinoin.

  Neurology 20031014

• Synthesis of pyrimidinopyridine-triazene conjugates targeted to abl tyrosine kinase.

  Bioorganic & medicinal chemistry letters 20031006

• Temozolomide: too early for definitive conclusions.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031001

• The role of chemotherapy in brain metastases.

  European journal of cancer (Oxford, England : 1990) 20031001

• Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts.

  Molecular cancer therapeutics 20031001

• A first feasibility study of temozolomide for Japanese patients with recurrent anaplastic astrocytoma and glioblastoma multiforme.

  International journal of clinical oncology 20031001

• Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.

  DNA repair 20030918

• Repopulating defect of mismatch repair-deficient hematopoietic stem cells.

  Blood 20030901

• Role of mismatch repair in the induction of chromosomal aberrations and sister chromatid exchanges in cells treated with different chemotherapeutic agents.

  Cancer chemotherapy and pharmacology 20030901

• Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide.

  British journal of cancer 20030901

• Phase II study of temozolomide plus thalidomide for the treatment of metastatic melanoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030901

• Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030901

• Treatment of glioblastoma multiforme in the elderly in functionally non-critical areas. Clinical remarks on 22 patients.

  Journal of experimental & clinical cancer research : CR 20030901

• Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.

  British journal of cancer 20030804

• Summary version of the Standards, Options and Recommendations for the management of adult patients with intracranial glioma (2002).

  British journal of cancer 20030801

• Inhibition of angiogenesis by non-toxic doses of temozolomide.

  Anti-cancer drugs 20030801

• Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas.

  British journal of cancer 20030721

• Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells.

  Blood 20030715

• Experimental design and sample size determination for testing synergism in drug combination studies based on uniform measures.

  Statistics in medicine 20030715

• Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells.

  Cancer chemotherapy and pharmacology 20030701

• Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030701

• Randomized phase II study of temozolomide given every 8 hours or daily with either interferon alfa-2b or thalidomide in metastatic malignant melanoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030701

• Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030701

• Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.

  Molecular cancer therapeutics 20030701

• Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030615

• Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models.

  The Journal of pharmacology and experimental therapeutics 20030601

• Temozolomide in patients with advanced non-small cell lung cancer with and without brain metastases. a phase II study of the EORTC Lung Cancer Group (08965).

  European journal of cancer (Oxford, England : 1990) 20030601

• Phase II evaluation of temozolomide in metastatic choroidal melanoma.

  Melanoma research 20030601

• Formation of DNA adducts and induction of lacI mutations in Big Blue Rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric brain tumors.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030601

• Pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of azolotetrazines with potent antitumor activity.

  Bioorganic & medicinal chemistry 20030529

• Metabolic activation of temozolomide measured in vivo using positron emission tomography.

  Cancer research 20030515

• Irinotecan in the treatment of glioma patients: current and future studies of the North Central Cancer Treatment Group.

  Cancer 20030501

• The emerging role of irinotecan (CPT-11) in the treatment of malignant glioma in brain tumors.

  Cancer 20030501

• Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas.

  Cancer 20030501

• Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas.

  Journal of pediatric hematology/oncology 20030501

• Irinotecan: promising activity in the treatment of malignant glioma.

  Oncology (Williston Park, N.Y.) 20030501

• Phase I. Trial of irinotecan and temozolomide in patients with solid tumors.

  Oncology (Williston Park, N.Y.) 20030501

• Phase I study of temozolomide and escalating doses of oral etoposide for adults with recurrent malignant glioma.

  Cancer 20030415

• Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules.

  British journal of cancer 20030407

• Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972.

  Annals of oncology : official journal of the European Society for Medical Oncology 20030401

• Recent developments in the molecular characterization and treatment of oligodendroglial tumors.

  Neuro-oncology 20030401

• O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030401

• Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor.

  Molecular cancer therapeutics 20030401

• Radiochemotherapy of malignant glioma in adults. Clinical experiences.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030401

• DNA repair enzymes and cytotoxic effects of temozolomide: comparative studies between tumor cells and normal cells of the immune system.

  Journal of chemotherapy (Florence, Italy) 20030401

• Treatment of brain metastases: a short review of current therapies and the emerging role of temozolomide.

  Clinical advances in hematology & oncology : H&O 20030401

• Interobserver variability in the radiological assessment of response to chemotherapy in glioma.

  Neurology 20030311

• Atypical presentation and progression of glioblastoma multiforme in a 6-year-old girl: multidisciplinary case report.

  Journal of pediatric hematology/oncology 20030301

• Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity.

  Journal of neurosurgery 20030301

• Survival with dacarbazine and fotemustine in newly diagnosed glioblastoma multiforme.

  British journal of cancer 20030224

• Phase II trial of temozolomide in patients with progressive low-grade glioma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030215

• Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids.

  British journal of cancer 20030210

• [Interstitial boost and altered fractionation as novel approaches to dose escalation in the radiotherapy of glioblastoma multiforme].

  Orvosi hetilap 20030202

• The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin.

  The Journal of pharmacology and experimental therapeutics 20030201

• A prospective study on glioblastoma in the elderly.

  Cancer 20030201

• Plasma and cerebrospinal fluid pharmacokinetics of intravenous temozolomide in non-human primates.

  Journal of neuro-oncology 20030201

• Impact of chromosome 1p status in response of oligodendroglioma to temozolomide: preliminary results.

  Journal of neuro-oncology 20030201

• Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFN alpha in patients with metastatic melanoma.

  British journal of cancer 20030127

• Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.

  Journal of medicinal chemistry 20030116

• [Treatment of melanoma].

  Presse medicale (Paris, France : 1983) 20030111

• Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.

  Molecular pharmacology 20030101

• Temozolomide in combination with interferon alpha-2b in patients with metastatic melanoma: a phase I dose-escalation study.

  Cancer 20030101

• Use of temozolomide with other cytotoxic chemotherapy in the treatment of patients with recurrent brain metastases from lung cancer.

  The oncologist 20030101

• Pharmacokinetics of radiolabelled anticancer drugs for positron emission tomography.

  Current pharmaceutical design 20030101

• Advances in molecular therapies in patients with brain tumors.

  Cancer control : journal of the Moffitt Cancer Center 20030101

• Current chemotherapy for glioblastoma.

  Cancer journal (Sudbury, Mass.) 20030101

• Survival of patients with recurrent malignant glioma treated with temozolomide: a retrospective observational study.

  Drugs in R&D 20030101

• Pharmacology of oral chemotherapy agents.

  Clinical journal of oncology nursing 20030101

• Medication sheets for patients. Oral chemotherapy.

  Clinical journal of oncology nursing 20030101

• Guidelines for the treatment of oligodendroglioma: an evidence-based medicine approach.

  Forum (Genoa, Italy) 20030101

• New drugs and combinations for malignant glioma.

  Forum (Genoa, Italy) 20030101

• Health-related quality of life in patients with advanced metastatic melanoma: results of a randomized phase III study comparing temozolomide with dacarbazine.

  Cancer investigation 20030101

• Quality of life, at what cost?

  Cancer investigation 20030101

• Temozolomide in radio-chemotherapy combined treatment for newly-diagnosed glioblastoma multiforme: phase II clinical trial.

  Anticancer research 20030101

• Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001.

  Journal of the National Cancer Institute 20021218

• Temozolomide in malignant gliomas of childhood: a United Kingdom Children's Cancer Study Group and French Society for Pediatric Oncology Intergroup Study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20021215

• Immunophenotypical markers, ultrastructure and chemosensitivity profile of metastatic melanoma cells.

  Cancer letters 20021205

• Antitumor imidazotetrazines. 40. Radiosyntheses of [4-11C-carbonyl]- and [3-N-11C-methyl]-8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (temozolomide) for positron emission tomography (PET) studies.

  Journal of medicinal chemistry 20021205

• Antitumor imidazotetrazines. 41. Conjugation of the antitumor agents mitozolomide and temozolomide to peptides and lexitropsins bearing DNA major and minor groove-binding structural motifs.

  Journal of medicinal chemistry 20021205

• Recurrent malignant glioma in adults.

  Current treatment options in oncology 20021201

• Developing therapeutic pharmaceuticals for the treatment of soft-tissue sarcomas.

  Expert opinion on investigational drugs 20021201

• New drugs for the treatment of cancer, 1990-2001.

  The Israel Medical Association journal : IMAJ 20021201

• Temozolomide and cisplatin in the treatment of leptomeningeal metastatic involvement from melanoma: a case report.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20021201

• [Complete response of cerebral metastasic melanoma after a combined treatment of radiotherapy and temozolomide].

  Medicina clinica 20021130

• Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.

  Journal of medicinal chemistry 20021107

• Oral cancer treatment: developments in chemotherapy and beyond.

  British journal of cancer 20021021

• Treatment of paediatric pontine glioma with oral trophosphamide and etoposide.

  British journal of cancer 20021021

• Treatment of disseminated ocular melanoma with sequential fotemustine, interferon alpha, and interleukin 2.

  British journal of cancer 20021007

• Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.

  Glia 20021001

• [Temozolomide as therapeutic option for patients with metastatic melanoma and poor prognosis].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20021001

• A phase II study of temozolomide in patients with newly diagnosed supratentorial malignant glioma before radiation therapy.

  Neuro-oncology 20021001

• Treatment of leptomeningeal relapse of medulloblastoma with temozolomide.

  Journal of pediatric hematology/oncology 20021001

• A phase II pilot trial of concurrent biochemotherapy with cisplatin, vinblastine, temozolomide, interleukin 2, and IFN-alpha 2B in patients with metastatic melanoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20021001

• Chemotherapy for the treatment of metastatic brain tumors.

  Expert review of anticancer therapy 20021001

• Advances in diagnosis and management of oligodendroglioma.

  Expert review of anticancer therapy 20021001

• Hemorrhagic cystitis as an unexpected adverse reaction to temozolomide: case report.

  American journal of clinical oncology 20021001

• Systemic chemotherapy for the treatment of metastatic melanoma.

  Seminars in oncology 20021001

• The treatment of brain metastases from malignant melanoma.

  Seminars in oncology 20021001

• Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells.

  Cancer gene therapy 20020901

• Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020901

• Small-sample inference for incomplete longitudinal data with truncation and censoring in tumor xenograft models.

  Biometrics 20020901

• Base excision repair as a therapeutic target in colon cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020901

• The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020901

• Case report: a patient with primary CNS lymphoma treated with temozolomide to complete response.

  Journal of neuro-oncology 20020901

• O6-benzylguanine-mediated enhancement of chemotherapy.

  Molecular cancer therapeutics 20020901

• Weekly gemcitabine plus Epirubicin as effective chemotherapy for advanced pancreatic cancer: a multicenter phase II study.

  British journal of cancer 20020827

• Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model.

  International journal of cancer 20020810

• Phase I study of temozolomide in relapsed/refractory acute leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020801

• Multifaceted resistance of gliomas to temozolomide.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020801

• A phase II trial of oral temozolomide in patients with metastatic renal cell cancer.

  Cancer chemotherapy and pharmacology 20020801

• Evaluation of the efficiency of chemotherapy in in vivo orthotopic models of human glioma cells with and without 1p19q deletions and in C6 rat orthotopic allografts serving for the evaluation of surgery combined with chemotherapy.

  Cancer 20020801

• Treatment of newly diagnosed glioblastoma multiforme.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020715

• Promising survival and concomitant radiation plus temozolomide followed by adjuvant temozolomide.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020715

• Pharmacological strategies to increase the antitumor activity of methylating agents.

  Current medicinal chemistry 20020701

• Temozolomide-induced flare in high-grade gliomas: a new clinical entity.

  Internal medicine journal 20020701

• Heterogeneity of O6-alkylguanine DNA-alkyltransferase expression in human breast tumours.

  British journal of cancer 20020605

• Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.

  Cancer research 20020601

• Temozolomide plus thalidomide in patients with advanced melanoma: results of a dose-finding trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020601

• First-line therapy with temozolomide induces regression of primary CNS lymphoma.

  Neurology 20020528

• [Treatment of recidive malignant gliomas with temozolomide].

  Orvosi hetilap 20020526

• Clinical relevance of MGMT in the treatment of cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020501

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20020501

• Temozolomide as second-line chemotherapy for relapsed gliomas.

  Journal of neuro-oncology 20020501

• Temozolomide in non-small-cell lung cancer: preliminary results of a phase II trial in previously treated patients.

  Clinical lung cancer 20020501

• Cancer Research UK procedures in manufacture and toxicology of radiotracers intended for pre-phase I positron emission tomography studies in cancer patients.

  British journal of cancer 20020408

• Photodynamic therapy of DNA mismatch repair-deficient and -proficient tumour cells.

  British journal of cancer 20020408

• Effect of temozolomide on central nervous system relapse in patients with advanced melanoma.

  Melanoma research 20020401

• Temozolomide and whole brain irradiation in melanoma metastatic to the brain: a phase II trial of the Cytokine Working Group.

  Journal of cancer research and clinical oncology 20020401

• A phase II EORTC study of temozolomide in patients with malignant pleural mesothelioma.

  European journal of cancer (Oxford, England : 1990) 20020401

• Biochemical changes associated with a multidrug-resistant phenotype of a human glioma cell line with temozolomide-acquired resistance.

  Biochemical pharmacology 20020401

• Synthesis and antibacterial activity of dual-action agents of a beta-lactam antibiotic with cytotoxic agent mitozolomide or temozolomide.

  European journal of medicinal chemistry 20020401

• The use of temozolomide in recurrent malignant gliomas.

  Cancer treatment reviews 20020401

• Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site.

  Blood 20020315

• Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase.

  Cancer research 20020315

• Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020301

• Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020301

• NICE verdict on Temozolomide: where next?

  British journal of cancer 20020212

• A rapid and systematic review of the effectiveness of temozolomide for the treatment of recurrent malignant glioma.

  British journal of cancer 20020212

• Temozolomide in combination with docetaxel in patients with advanced melanoma: a phase II study of the Hellenic Cooperative Oncology Group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020115

• A phase II study of extended low-dose temozolomide in recurrent malignant gliomas.

  Neuro-oncology 20020101

• Pharmacokinetic considerations of oral chemotherapy in elderly patients with cancer.

  Drugs & aging 20020101

• Temozolomide in glioblastoma multiforme of the elderly.

  Tumori 20020101

• Combined radiotherapy and temozolomide in patients with recurrent high grade glioma.

  Tumori 20020101

• Concomitant radiotherapy and metronomic temozolomide in pediatric high-risk brain tumors.

  Neoplasma 20020101

• Temozolomide in patients with glioblastoma at second relapse after first line nitrosourea-procarbazine failure: a phase II study.

  Oncology 20020101

• Temozolomide in second-line treatment after prior nitrosurea-based chemotherapy in glioblastoma multiforme: experience from a Portuguese institution.

  International journal of clinical pharmacology research 20020101

• [Treatment of anaplastic astrocytomas and glioblastomas in children by the use of temozolomide (TMZ)].

  Voprosy onkologii 20020101

• Search of antimicrobial activity of selected non-antibiotic drugs.

  Acta poloniae pharmaceutica 20020101

• Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011201

• Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.

  Journal of neuro-oncology 20011201

• Low-grade gliomas.

  Current treatment options in oncology 20011201

• Adults with newly diagnosed high-grade gliomas.

  Current treatment options in oncology 20011201

• Possible efficacy of temozolomide in a patient with gliomatosis cerebri.

  Neurology 20011127

• New strategy developments in brain tumor therapy.

  Current pharmaceutical design 20011101

• Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas.

  Neuro-oncology 20011001

• Targeting DNA mismatch repair for radiosensitization.

  Seminars in radiation oncology 20011001

• Treatment of metastatic melanoma in the brain with temozolomide and thalidomide.

  The Lancet. Oncology 20011001

• New perspectives for the diagnosis and treatment of oligodendroglioma.

  Expert review of anticancer therapy 20011001

• Temozolomide enhances herpes simplex virus thymidine kinase/ganciclovir therapy of malignant glioma.

  Cancer gene therapy 20010901

• Current and future developments in the use of temozolomide for the treatment of brain tumours.

  The Lancet. Oncology 20010901

• Treatment of brain metastases of malignant melanoma with temozolomide.

  The New England journal of medicine 20010823

• Adenovirally-mediated transfer of E2F-1 potentiates chemosensitivity of human glioma cells to temozolomide and BCNU.

  International journal of oncology 20010801

• hMSH3 overexpression and cellular response to cytotoxic anticancer agents.

  Carcinogenesis 20010801

• Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.

  Cancer research 20010801

• Temozolomide: the effect of once- and twice-a-day dosing on tumor tissue levels of the DNA repair protein O(6)-alkylguanine-DNA-alkyltransferase.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010801

• Temozolomide for recurrent high-grade glioma.

  Seminars in oncology 20010801

• Chemotherapy for the treatment of oligodendroglial tumors.

  Seminars in oncology 20010801

• New approaches for temozolomide therapy: use in newly diagnosed glioma.

  Seminars in oncology 20010801

• Temozolomide in combination with other cytotoxic agents.

  Seminars in oncology 20010801

• Temozolomide for treating brain metastases.

  Seminars in oncology 20010801

• Future directions for temozolomide therapy.

  Seminars in oncology 20010801

• Temozolomide chemotherapy in recurrent oligodendroglioma.

  Neurology 20010724

• Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470.

  Cancer research 20010715

• CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release.

  Oncogene 20010712

• An Australian experience with temozolomide for the treatment of recurrent high grade gliomas.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20010701

• Kinetics of neutrophil production in normal and neutropenic animals during the response to filgrastim (r-metHu G-CSF) or filgrastim SD/01 (PEG-r-metHu G-CSF).

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010701

• Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolites of penclomedine.

  Cancer chemotherapy and pharmacology 20010701

• Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.

  European journal of haematology 20010701

• A phase II trial of temozolomide for patients with recurrent or progressive brain metastases.

  Journal of neuro-oncology 20010701

• Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines.

  International journal of oncology 20010601

• Metastatic melanoma.

  Current treatment options in oncology 20010601

• Temozolomide: a novel oral alkylating agent.

  Expert review of anticancer therapy 20010601

• Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice.

  Cancer research 20010515

• Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells.

  Mutation research 20010510

• Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010501

• Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010501

• Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells.

  Cell death and differentiation 20010501

• Inducible nitric oxide synthase neutralizes carbamoylating potential of 1,3-bis(2-chloroethyl)-1-nitrosourea in c6 glioma cells.

  The Journal of pharmacology and experimental therapeutics 20010401

• Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components.

  Cancer chemotherapy and pharmacology 20010401

• Design of a chimeric 3-methyl-1,2,3-triazene with mixed receptor tyrosine kinase and DNA damaging properties: a novel tumor targeting strategy.

  The Journal of pharmacology and experimental therapeutics 20010301

• Development and application of a sensitive and rapid immunoassay for the quantitation of N7-methyldeoxyguanosine in DNA samples.

  Chemical research in toxicology 20010301

• p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

  Cancer research 20010301

• Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells.

  Gene therapy 20010301

• Atypical teratoid/rhabdoid tumors in adult patients: case report and review of the literature.

  Journal of neuro-oncology 20010301

• Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010201

• Phase II study of temozolomide in heavily pretreated cancer patients with brain metastases.

  Annals of oncology : official journal of the European Society for Medical Oncology 20010201

• Temozolomide as a second-line systemic regimen in recurrent high-grade glioma: a phase II study.

  Annals of oncology : official journal of the European Society for Medical Oncology 20010201

• Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse.

  Annals of oncology : official journal of the European Society for Medical Oncology 20010201

• Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector.

  Molecular therapy : the journal of the American Society of Gene Therapy 20010101

• High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma.

  Journal of pharmaceutical and biomedical analysis 20010101

• Combined treatment with high-dose methotrexate, vincristine and procarbazine, without intrathecal chemotherapy, followed by consolidation radiotherapy for primary central nervous system lymphoma in immunocompetent patients.

  Oncology 20010101

• Thalidomide as an anti-angiogenic agent in relapsed gliomas.

  Journal of neuro-oncology 20010101

• The effectiveness and cost-effectiveness of temozolomide for the treatment of recurrent malignant glioma: a rapid and systematic review.

  Health technology assessment (Winchester, England) 20010101

• Mapping therapeutic response in a patient with malignant glioma.

  Journal of computer assisted tomography 20010101

• Late recurrence of a primitive neuro-ectodermal tumor.

  Oncology 20010101

• Controversies in the management of brain metastases: the role of chemotherapy.

  Forum (Genoa, Italy) 20010101

• Therapeutic management of refractory or relapsed primary central nervous system lymphomas.

  Annals of hematology 20010101

• Temozolomide (Temodar).

  Clinical journal of oncology nursing 20010101

• Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.

  Cancer research 20001001

• Temozolomide and treatment of malignant glioma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20000701

• Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20000701

• Temozolomide in malignant gliomas.

  Seminars in oncology 20000601

• Phase II study of temozolomide in patients with relapsing high grade glioma and poor performance status.

  Medical oncology (Northwood, London, England) 20000501

• In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.

  Carcinogenesis 20000401

• Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20000101

• Tetrazepinones are equally cytotoxic to Mer+ and Mer- human tumor cell lines.

  The Journal of pharmacology and experimental therapeutics 19990201

• Cisplatin increases sensitivity of human leukemic blasts to triazene compounds.

  Journal of chemotherapy (Florence, Italy) 19950601

• Temozolomide treatment for aggressive pituitary tumors: correlation of clinical outcome with O(6)-methylguanine methyltransferase (MGMT) promoter methylation and expression.

  The Journal of clinical endocrinology and metabolism