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Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR.
Chemico-biological interactions 20180801
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Vosaroxin induces mitochondrial dysfunction and apoptosis in cervical cancer HeLa cells: Involvement of AMPK/Sirt3/HIF-1 pathway.
Chemico-biological interactions 20180625
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Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase.
Chemico-biological interactions 20180601
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Traditional herbal medicine-derived sulforaphene promotes mitophagic cell death in lymphoma cells through CRM1-mediated p62/SQSTM1 accumulation and AMPK activation.
Chemico-biological interactions 20180201
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Baicalin protects AML-12 cells from lipotoxicity via the suppression of ER stress and TXNIP/NLRP3 inflammasome activation.
Chemico-biological interactions 20171225
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4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.
Toxicology letters 20170205
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Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats.
Archives of toxicology 20170101
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Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox(ukn) and STOP-Tox(ukk) tests.
Archives of toxicology 20170101
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Vagal nerve stimulation improves mitochondrial dynamics via an M(3) receptor/CaMKKβ/AMPK pathway in isoproterenol-induced myocardial ischaemia.
Journal of cellular and molecular medicine 20170101
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Effect of A-769662, a direct AMPK activator, on Tlr-4 expression and activity in mice heart tissue.
Iranian journal of basic medical sciences 20161201
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From the Cover: Autophagy Induction Contributes to Cadmium Toxicity in Mesenchymal Stem Cells via AMPK/FOXO3a/BECN1 Signaling.
Toxicological sciences : an official journal of the Society of Toxicology 20161101
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Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes.
Toxicology 20160831
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Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.
Molecular oncology 20160601
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Quercetin oppositely regulates insulin-mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation.
Molecular nutrition & food research 20160301
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Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway.
Phytotherapy research : PTR 20160301
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Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation.
Annals of the rheumatic diseases 20160201
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Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK.
Journal of neuroinflammation 20160101
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Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation.
Autophagy 20160101
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Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.
Chemico-biological interactions 20151005
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Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK.
Molecular and cellular endocrinology 20150905
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Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway.
Molecular nutrition & food research 20150801
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Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1.
International journal of obesity (2005) 20150601
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A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression.
Experimental hematology 20150501
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Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis.
Toxicology 20150102
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Biologically active, high levels of interleukin-22 inhibit hepatic gluconeogenesis but do not affect obesity and its metabolic consequences.
Cell & bioscience 20150101
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Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells.
Cell death & disease 20141201
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Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling.
European journal of pain (London, England) 20141101
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Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.
Pharmacological research 20141101
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AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1.
The FEBS journal 20141001
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Resveratrol prevents AngII-induced hypertension via AMPK activation and RhoA/ROCK suppression in mice.
Hypertension research : official journal of the Japanese Society of Hypertension 20140901
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Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent.
Journal of medicinal chemistry 20140522
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Quercetin differently regulates insulin-mediated glucose transporter 4 translocation under basal and inflammatory conditions in adipocytes.
Molecular nutrition & food research 20140501
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Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.
British journal of pharmacology 20140501
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Inhibitory effects of resveratrol on foam cell formation are mediated through monocyte chemotactic protein-1 and lipid metabolism-related proteins.
International journal of molecular medicine 20140501
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Resveratrol down-regulates a glutamate-induced tissue plasminogen activator via Erk and AMPK/mTOR pathways in rat primary cortical neurons.
Food & function 20140501
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The role of AMP-activated protein kinase in quercetin-induced apoptosis of HL-60 cells.
Acta biochimica et biophysica Sinica 20140501
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Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140301
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Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1.
Journal of lipid research 20140301
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Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes.
Toxicology and applied pharmacology 20140115
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A high-throughput screen for teratogens using human pluripotent stem cells.
Toxicological sciences : an official journal of the Society of Toxicology 20140101
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Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Archives of pharmacal research 20140101
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Salidroside stimulates osteoblast differentiation through BMP signaling pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20131201
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Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway.
Autophagy 20131201
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Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
The Biochemical journal 20130901
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S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.
The Journal of nutritional biochemistry 20130801
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Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters 20130801
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Autophagic cell death induced by resveratrol depends on the Ca(2+)/AMPK/mTOR pathway in A549 cells.
Biochemical pharmacology 20130715
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Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.
Bioorganic & medicinal chemistry letters 20130601
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Reversal of P-glycoprotein-mediated multidrug resistance is induced by mollugin in MCF-7/adriamycin cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology 20130515
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A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
The Biochemical journal 20130415
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Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells.
Toxicology and applied pharmacology 20130301
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p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells.
Toxicology and applied pharmacology 20130215
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Resveratrol pre-treatment reduces early inflammatory responses induced by status epilepticus via mTOR signaling.
Brain research 20130125
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Quercetin but not quercitrin ameliorates tumor necrosis factor-alpha-induced insulin resistance in C2C12 skeletal muscle cells.
Biological & pharmaceutical bulletin 20130101
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ULK1 plays a critical role in AMPK-mediated myocardial autophagy and contractile dysfunction following acute alcohol challenge.
Current pharmaceutical design 20130101
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BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells.
PloS one 20130101
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Potent vasodilation effect of amurensin G is mediated through the phosphorylation of endothelial nitric oxide synthase.
Biochemical pharmacology 20121201
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AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells.
Journal of surgical oncology 20121101
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Acute exposure to resveratrol inhibits AMPK activity in human skeletal muscle cells.
Diabetologia 20121101
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AMP-activated protein kinase upregulates glucose uptake in thyroid PCCL3 cells independent of thyrotropin.
Thyroid : official journal of the American Thyroid Association 20121001
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Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.
American journal of physiology. Gastrointestinal and liver physiology 20120915
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The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis.
The Journal of biological chemistry 20120824
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AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase.
Journal of cellular physiology 20120801
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Involvement of AMP-activated protein kinase in thrombin-stimulated interleukin 6 synthesis in osteoblasts.
Journal of molecular endocrinology 20120801
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The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism.
Molecular endocrinology (Baltimore, Md.) 20120701
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Effects of the AMP-activated protein kinase inhibitor compound C on the postconditioned rat heart.
The journal of physiological sciences : JPS 20120701
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AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.
Circulation research 20120427
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BMP signaling is responsible for serum-induced Id2 expression.
Biochemical and biophysical research communications 20120406
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Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP-activated protein kinase.
Journal of cellular physiology 20120401
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The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα.
Pharmaceutical biology 20120401
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Bone morphogenetic protein (BMP) signaling regulates mitotic checkpoint protein levels in human breast cancer cells.
Cellular signalling 20120401
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Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells.
Molecular medicine reports 20120401
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Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation.
European journal of immunology 20120301
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Alternol exerts prostate-selective antitumor effects through modulations of the AMPK signaling pathway.
The Prostate 20120201
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Role of AMP-activated protein kinase in α-lipoic acid-induced vasodilatation in spontaneously hypertensive rats.
American journal of hypertension 20120201
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Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells.
Chemico-biological interactions 20120105
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The adenosine derivative 2',3',5'-tri-O-acetyl-N6-(3-hydroxylaniline) adenosine activates AMPK and regulates lipid metabolism in vitro and in vivo.
Life sciences 20120102
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AMP-activated protein kinase regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts: involvement of mitogen-activated protein kinases.
Life sciences 20120102
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Prunus yedoensis Matsum. stimulates glucose uptake in L6 rat skeletal muscle cells by activating AMP-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.
Natural product research 20120101
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BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm.
Developmental biology 20120101
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Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK.
PloS one 20120101
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Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells.
PloS one 20120101
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AMP-activated protein kinase plays an important evolutionary conserved role in the regulation of glucose metabolism in fish skeletal muscle cells.
PloS one 20120101
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Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes.
PloS one 20120101
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Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
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Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling.
PloS one 20120101
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Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells.
PloS one 20120101
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Metformin stimulates FGF21 expression in primary hepatocytes.
Experimental diabetes research 20120101
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Glomerular endothelial PI3 kinase-α couples to VEGFR2, but is not required for eNOS activation.
American journal of physiology. Renal physiology 20111201
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AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation.
American journal of physiology. Renal physiology 20111201
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The specificities of small molecule inhibitors of the TGFß and BMP pathways.
Cellular signalling 20111101
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Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo.
Atherosclerosis 20111101
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Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway.
Genes to cells : devoted to molecular & cellular mechanisms 20111101
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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nature biotechnology 20111101
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Supplementation of pyruvate prevents palmitate-induced impairment of glucose uptake in C2 myotubes.
Molecular and cellular endocrinology 20111015
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Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway.
European journal of pharmacology 20111001
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Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors.
ACS chemical biology 20110916
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Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells.
Toxicology and applied pharmacology 20110915
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Acute rosiglitazone treatment is cardioprotective against ischemia-reperfusion injury by modulating AMPK, Akt, and JNK signaling in nondiabetic mice.
American journal of physiology. Heart and circulatory physiology 20110901
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Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells.
Anatomy & cell biology 20110901
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Compound C stimulates heme oxygenase-1 gene expression via the Nrf2-ARE pathway to preserve human endothelial cell survival.
Biochemical pharmacology 20110815
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Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways.
Chemical Society reviews 20110814
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AICAR and Compound C regulate food intake independently of AMP-activated protein kinase in lines of chickens selected for high or low body weight.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20110801
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Ischemia-induced stimulation of Na-K-Cl cotransport in cerebral microvascular endothelial cells involves AMP kinase.
American journal of physiology. Cell physiology 20110801
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Compound C inhibits vascular smooth muscle cell proliferation and migration in an AMP-activated protein kinase-independent fashion.
The Journal of pharmacology and experimental therapeutics 20110801
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Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease.
Neuro-Signals 20110801
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Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells.
American journal of respiratory cell and molecular biology 20110701
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Simulated microgravity promoted differentiation of bipotential murine oval liver stem cells by modulating BMP4/Notch1 signaling.
Journal of cellular biochemistry 20110701
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Post-stroke hypothermia provides neuroprotection through inhibition of AMP-activated protein kinase.
Journal of neurotrauma 20110701
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Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-κB modulation in HepG2 hepatocarcinoma cells.
International journal of molecular medicine 20110701
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Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell.
Journal of cellular physiology 20110701
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Berberine acutely activates the glucose transport activity of GLUT1.
Biochimie 20110701
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Identification of new inhibitors of protein kinase R guided by statistical modeling.
Bioorganic & medicinal chemistry letters 20110701
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Adiponectin protects rat hippocampal neurons against excitotoxicity.
Age (Dordrecht, Netherlands) 20110601
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Inhibition of AMPK-associated autophagy enhances caffeic acid phenethyl ester-induced cell death in C6 glioma cells.
Planta medica 20110601
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Novel role of AMP-activated protein kinase signaling in cigarette smoke induction of IL-8 in human lung epithelial cells and lung inflammation in mice.
Free radical biology & medicine 20110601
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Possible functions of Dpp in gastropod shell formation and shell coiling.
Development genes and evolution 20110601
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Bezafibrate enhances proliferation and differentiation of osteoblastic MC3T3-E1 cells via AMPK and eNOS activation.
Acta pharmacologica Sinica 20110501
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Cinnamaldehyde prevents adipocyte differentiation and adipogenesis via regulation of peroxisome proliferator-activated receptor-γ (PPARγ) and AMP-activated protein kinase (AMPK) pathways.
Journal of agricultural and food chemistry 20110427
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Dorsomorphin promotes human embryonic stem cell self-renewal.
Angewandte Chemie (International ed. in English) 20110404
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Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation.
Metabolism: clinical and experimental 20110401
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Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice.
British journal of pharmacology 20110401
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Smad signaling determines chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells: inhibition of Smad1/5/8P prevents terminal differentiation and calcification.
Tissue engineering. Part A 20110401
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Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway.
The Journal of pharmacology and experimental therapeutics 20110401
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Leptin controls ketone body utilization in hypothalamic neuron.
Neuroscience letters 20110303
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BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells.
Cell death and differentiation 20110201
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Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation.
Cardiovascular research 20110201
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Metformin decreases GnRH- and activin-induced gonadotropin secretion in rat pituitary cells: potential involvement of adenosine 5' monophosphate-activated protein kinase (PRKA).
Biology of reproduction 20110201
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Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells.
Journal of neuroscience research 20110201
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Up-regulation of adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinase signaling pathways and DsbA-L.
The Journal of biological chemistry 20110107
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Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.
Autophagy 20110101
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Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival.
American journal of physiology. Heart and circulatory physiology 20110101
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Detection of signaling effector-complexes downstream of bmp4 using PLA, a proximity ligation assay.
Journal of visualized experiments : JoVE 20110101
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Biomechanical forces exert anabolic effects on osteoblasts by activation of SMAD 1/5/8 through type 1 BMP receptor.
Biorheology 20110101
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The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK.
PloS one 20110101
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meso-Dihydroguaiaretic acid inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.
Biological & pharmaceutical bulletin 20110101
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Potentiation of neuronal insulin signaling and glucose uptake by resveratrol: the involvement of AMPK.
Pharmacological reports : PR 20110101
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Small molecule promoted feeder free and adherent differentiation of functional neurons from human embryonic and induced pluripotent stem cells.
Journal of stem cells 20110101
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Astrocyte elevated gene-1 induces protective autophagy.
Proceedings of the National Academy of Sciences of the United States of America 20101221
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Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase.
American journal of physiology. Cell physiology 20101201
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Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability.
Experimental eye research 20101201
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The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity.
Bioorganic & medicinal chemistry letters 20101115
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AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition.
Cellular signalling 20101101
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Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.
The international journal of biochemistry & cell biology 20101101
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AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts.
Bone 20101101
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A role for AMPK in increased insulin action after serum starvation.
American journal of physiology. Cell physiology 20101101
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Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice.
Biochemical and biophysical research communications 20101008
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Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARα dependent mechanism.
The American journal of pathology 20101001
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High-efficiency induction of neural conversion in human ESCs and human induced pluripotent stem cells with a single chemical inhibitor of transforming growth factor beta superfamily receptors.
Stem cells (Dayton, Ohio) 20101001
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Role of AMPK throughout meiotic maturation in the mouse oocyte: evidence for promotion of polar body formation and suppression of premature activation.
Molecular reproduction and development 20101001
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Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
International journal of radiation oncology, biology, physics 20100901
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Intersegmental vessel formation in zebrafish: requirement for VEGF but not BMP signalling revealed by selective and non-selective BMP antagonists.
British journal of pharmacology 20100901
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Identification of early requirements for preplacodal ectoderm and sensory organ development.
PLoS genetics 20100901
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Rosiglitazone inhibits monocyte/macrophage adhesion through de novo adiponectin production in human monocytes.
Journal of cellular biochemistry 20100815
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AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha and nuclear respiratory factor 1 expression in rat visual cortical neurons.
Neuroscience 20100811
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Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1.
Experimental cell research 20100801
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A pharmacological activator of AMP-activated protein kinase protects hypoxic neurons in a concentration-dependent manner.
Neurochemical research 20100801
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AMPK enhances the expression of pancreatic duodenal homeobox-1 via PPARalpha, but not PPARgamma, in rat insulinoma cell line INS-1.
Acta pharmacologica Sinica 20100801
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The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells.
Journal of medicinal food 20100801
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[Genetic basis for skeletal disease. Establishment of novel treatments for fibrodysplasia ossificans progressiva (FOP)].
Clinical calcium 20100801
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Inhibition of AMP-activated protein kinase pathway sensitizes human leukemia K562 cells to nontoxic concentration of doxorubicin.
Molecular and cellular biochemistry 20100701
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Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction.
Arteriosclerosis, thrombosis, and vascular biology 20100701
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SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK).
Cancer biology & therapy 20100701
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Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro.
Acta pharmacologica Sinica 20100701
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Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion.
Arteriosclerosis, thrombosis, and vascular biology 20100601
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Metformin-induced regulation of the intestinal D-glucose transporters.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100601
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Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Arteriosclerosis, thrombosis, and vascular biology 20100501
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AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.
The Journal of biological chemistry 20100319
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Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.
Oncogene 20100318
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BMP Inhibition with dorsomorphin limits adipogenic potential of preadipocytes.
The Journal of veterinary medical science 20100301
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In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.
ACS chemical biology 20100219
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Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.
Journal of agricultural and food chemistry 20100210
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Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype.
Cardiovascular research 20100201
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Expression and role of adiponectin receptor 1 in lipopolysaccharide-induced proliferation of cultured rat adventitial fibroblasts.
Cell biology international 20100201
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BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway.
Journal of cellular biochemistry 20100201
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Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia.
Naunyn-Schmiedeberg's archives of pharmacology 20100201
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Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction.
Cardiovascular drugs and therapy 20100201
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Beta-adrenergic-AMPK pathway phosphorylates acetyl-CoA carboxylase in a high-epinephrine rat model, SPORTS.
Obesity (Silver Spring, Md.) 20100101
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Bone morphogenetic protein receptors and signal transduction.
Journal of biochemistry 20100101
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AICAR (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures.
Neurotoxicology 20100101
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Ambivalent effects of compound C (dorsomorphin) on inflammatory response in LPS-stimulated rat primary microglial cultures.
Naunyn-Schmiedeberg's archives of pharmacology 20100101
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The novel function of nesfatin-1: anti-hyperglycemia.
Biochemical and biophysical research communications 20100101
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Suppression effects of AICAR on insulin secretion involved in peroxisome proliferator-activated receptor gamma changes in INS-1 cells.
Journal of endocrinological investigation 20100101
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Metabolic regulation of neuronal plasticity by the energy sensor AMPK.
PloS one 20100101
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The role of hypothalamic AMP-activated protein kinase in ovariectomy-induced obesity in rats.
Menopause (New York, N.Y.) 20100101
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The zebrafish embryo as a model for assessing off-target drug effects.
Disease models & mechanisms 20100101
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Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures.
Pharmacological reports : PR 20100101
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Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells.
Atherosclerosis 20091201
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AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.
Journal of lipid research 20091201
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AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase.
American journal of physiology. Cell physiology 20091201
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Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes.
FEBS letters 20091119
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Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-alpha signaling pathway.
European journal of pharmacology 20091012
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Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway.
Molecular pharmacology 20091001
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Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin.
Cell host & microbe 20090917
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Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner.
Hepatology (Baltimore, Md.) 20090901
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Central AMPK contributes to sleep homeostasis in mice.
Neuropharmacology 20090901
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Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes.
Clinical science (London, England : 1979) 20090814
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The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis.
Proceedings of the National Academy of Sciences of the United States of America 20090804
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Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.
Endocrinology 20090801
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AMPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism.
American journal of physiology. Endocrinology and metabolism 20090801
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Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway.
Annals of the New York Academy of Sciences 20090801
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Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells.
Annals of the New York Academy of Sciences 20090801
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Regulation of visceral and subcutaneous adipocyte lipolysis by acute AICAR-induced AMPK activation.
Obesity (Silver Spring, Md.) 20090701
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AMP-activated protein kinase influences metabolic remodeling in H9c2 cells hypertrophied by arginine vasopressin.
American journal of physiology. Heart and circulatory physiology 20090601
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AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
Biochemical pharmacology 20090601
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Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.
Circulation 20090519
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Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose.
American journal of physiology. Endocrinology and metabolism 20090501
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Regulation of erythrocyte survival by AMP-activated protein kinase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090401
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AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin.
Experimental & molecular medicine 20090331
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Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva.
The Journal of biological chemistry 20090313
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AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D.
The Journal of biological chemistry 20090306
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Regulation of Cl(-) secretion by AMPK in vivo.
Pflugers Archiv : European journal of physiology 20090301
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AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633.
Circulation research 20090227
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Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
Biochemical and biophysical research communications 20090227
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Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase.
The Journal of biological chemistry 20090116
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Applications of small molecule BMP inhibitors in physiology and disease.
Cytokine & growth factor reviews 20090101
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A unique mutation of ALK2, G356D, found in a patient with fibrodysplasia ossificans progressiva is a moderately activated BMP type I receptor.
Biochemical and biophysical research communications 20081219
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Differential regulation of AMP-activated kinase and AKT kinase in response to oxygen availability in crucian carp (Carassius carassius).
American journal of physiology. Regulatory, integrative and comparative physiology 20081201
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AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells.
Oncology reports 20081201
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BMP type I receptor inhibition reduces heterotopic [corrected] ossification.
Nature medicine 20081201
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Triiodothyronine (T3) stimulates food intake via enhanced hypothalamic AMP-activated kinase activity.
Regulatory peptides 20081129
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Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells.
Biochemical and biophysical research communications 20081121
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Compound C inhibits clonal expansion of preadipocytes by increasing p21 level irrespectively of AMPK inhibition.
Archives of biochemistry and biophysics 20081101
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AMP-activated protein kinase and hypoxic pulmonary vasoconstriction.
European journal of pharmacology 20081024
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AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells.
Arteriosclerosis, thrombosis, and vascular biology 20081001
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Effects of an AMP-activated protein kinase inhibitor, compound C, on adipogenic differentiation of 3T3-L1 cells.
Biological & pharmaceutical bulletin 20080901
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In vitro metformin anti-neoplastic activity in epithelial ovarian cancer.
Gynecologic oncology 20080801
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Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.
Bioorganic & medicinal chemistry letters 20080801
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Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.
The Journal of biological chemistry 20080606
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Activation of AMP-activated protein kinase, inhibition of pyruvate dehydrogenase activity, and redistribution of substrate partitioning mediate the acute insulin-sensitizing effects of troglitazone in skeletal muscle cells.
Journal of cellular physiology 20080501
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Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation.
Molecular and cellular endocrinology 20080326
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AMP-activated protein kinase phosphorylates transcription factors of the CREB family.
Journal of applied physiology (Bethesda, Md. : 1985) 20080201
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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.
Nature chemical biology 20080101
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Small-molecule dissection of BMP signaling.
Nature chemical biology 20080101
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Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK.
BMC immunology 20080101
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Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.
PloS one 20080101
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The selectivity of protein kinase inhibitors: a further update.
The Biochemical journal 20071215
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Compound C inhibits hypoxic activation of HIF-1 independent of AMPK.
FEBS letters 20071211
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The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia.
Cardiovascular research 20071201
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Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line.
American journal of physiology. Endocrinology and metabolism 20071201
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Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism.
Arteriosclerosis, thrombosis, and vascular biology 20071201
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Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling.
American journal of physiology. Endocrinology and metabolism 20071201
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Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress.
The Journal of biological chemistry 20070914
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Possible role of 5'AMP-activated protein kinase in the metformin-mediated arrest of bovine oocytes at the germinal vesicle stage during in vitro maturation.
Biology of reproduction 20070901
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Resveratrol stimulates AMP kinase activity in neurons.
Proceedings of the National Academy of Sciences of the United States of America 20070424
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Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway.
Cancer letters 20070308
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Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation.
American journal of physiology. Cell physiology 20070101
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The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis.
Experimental physiology 20070101
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Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity.
Diabetologia 20070101
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AMP-activated protein kinase and the regulation of autophagic proteolysis.
The Journal of biological chemistry 20061117
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Role of AMP-activated protein kinase in mechanism of metformin action.
The Journal of clinical investigation 20011015
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Noncanonical BMP signaling regulates cyclooxygenase-2 transcription.
Molecular endocrinology (Baltimore, Md.)