86770-67-4 | Ethanol,2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$10.00	$7.00
5g	97%	in stock	$98.00	$68.00
10g	97%	in stock	$193.00	$135.00
25g	97%	in stock	$465.00	$325.00

Description

• Catalog Number: AC23114
• Chemical Name: Ethanol,2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-
• CAS Number: 86770-67-4
• Molecular Formula: C8H17N3O4
• Molecular Weight: 219.23828000000003
• MDL Number: MFCD03701128
• SMILES: OCCOCCOCCOCCN=[N+]=[N-]

Upstream Synthesis Route

The upstream synthesis route for Ethanol,2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-, which is essentially a tetraethylene glycol derivative with an azido functional group, can be described in the following steps:

1. Starting with Tetraethylene Glycol: The synthesis begins with tetraethylene glycol, a readily available compound.

2. Activation of the Terminal Hydroxyl Groups: The hydroxyl groups at the end of the tetraethylene glycol molecule are activated to make them more reactive. This is typically done by converting them to a leaving group, such as a tosylate (p-toluenesulfonyl) using tosyl chloride in the presence of a base such as pyridine.

3. Nucleophilic Substitution with Sodium Azide: The activated tosylate groups then undergo nucleophilic substitution with sodium azide (NaN3). This step replaces the leaving group with the azido group, yielding the desired azidoethoxy functionalized compound.

4. Purification: The resulting azido compound may require purification, typically through column chromatography, to achieve the desired level of purity.

Throughout the synthesis, it is important to maintain anhydrous and aprotic conditions to prevent side reactions and degradation of the azide group. The reaction steps should be carried out under inert atmosphere conditions, usually using nitrogen or argon, to prevent exposure to potentially reactive atmospheric substances. Moreover, due to the potentially explosive nature of azides, especially in their pure form, care must be taken to perform the synthesis in small batches, using proper safety protocols and equipment.