869288-64-2 | PF-573228

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$42.00	$29.00
5mg	95%	in stock	$129.00	$90.00
10mg	95%	in stock	$218.00	$153.00
50mg	95%	in stock	$299.00	$209.00
100mg	95%	in stock	$593.00	$415.00
250mg	95%	in stock	$1,176.00	$823.00

Description

• Catalog Number: AC13997
• Chemical Name: PF-573228
• CAS Number: 869288-64-2
• Molecular Formula: C22H20F3N5O3S
• Molecular Weight: 491.4861
• MDL Number: MFCD11519967
• SMILES: O=C1CCc2c(N1)ccc(c2)Nc1ncc(c(n1)NCc1cccc(c1)S(=O)(=O)C)C(F)(F)F

Computed Properties

• Complexity: 822
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 6
• XLogP3: 3.2

Literature

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  Toxicology 20170601

• Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells.

  Toxicology and applied pharmacology 20160101

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts.

  American journal of physiology. Cell physiology 20121101

• Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy.

  Molecular cancer therapeutics 20120201

• Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.

  Cellular immunology 20120101

• Focal adhesion kinase inhibitors are potent anti-angiogenic agents.

  Molecular oncology 20111201

• Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228.

  Life sciences 20111107

• Effect of focal adhesion kinase on the regulation of realignment and tenogenic differentiation of human mesenchymal stem cells by mechanical stretch.

  Connective tissue research 20111001

• Both AT₁ and AT₂ receptors mediate proliferation and migration of porcine vascular smooth muscle cells.

  American journal of physiology. Heart and circulatory physiology 20110901

• Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110720

• Oxidative stress-induced degradation of thioredoxin-1 and apoptosis is inhibited by thioredoxin-1-actin interaction in endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20110301

• Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

  Breast cancer research and treatment 20110201

• DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.

  Oncogene 20101202

• Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes.

  Journal of neurochemistry 20101001

• Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts.

  Cellular signalling 20091201

• Characterization of a novel focal adhesion kinase inhibitor in human platelets.

  Biochemical and biophysical research communications 20091106

• Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.

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• Cellular characterization of a novel focal adhesion kinase inhibitor.

  The Journal of biological chemistry 20070518