883290-81-1 | 4-[(Carboxymethyl)(methyl)amino]benzoic acid

Packsize	Purity	Availability	Price	Discounted Price
1mg		2 weeks	$105.00	$73.00
2mg		2 weeks	$123.00	$86.00
3mg		2 weeks	$149.00	$105.00
5mg		2 weeks	$168.00	$118.00
10mg		2 weeks	$193.00	$135.00

Description

• Catalog Number: AV18523
• Chemical Name: 4-[(Carboxymethyl)(methyl)amino]benzoic acid
• CAS Number: 883290-81-1
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.1986
• MDL Number: MFCD01014170
• SMILES: OC(=O)CN(c1ccc(cc1)C(=O)O)C

Computed Properties

• Complexity: 246
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 1.2

Literature

• Experience-dependent switch in sign and mechanisms for plasticity in layer 4 of primary visual cortex.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120801

• Suppressive effect of preconditioning low-frequency stimulation on subsequent induction of long-term potentiation by high frequency stimulation in hippocampal CA3 neurons.

  Brain research 20120417

• Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.

  PLoS biology 20120201

• Synapse- and subtype-specific modulation of synaptic transmission by nicotinic acetylcholine receptors in the ventrobasal thalamus.

  Neuroscience research 20110301

• Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110201

• Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats.

  Aging cell 20101001

• Involvement of inositol-1,4,5-trisphosphate receptors in the bidirectional synaptic plasticity induced in hippocampal CA1 neurons by 1-10 Hz low-frequency stimulation.

  Neuroscience 20100630

• Assessment of different induction protocols to elicit long-term depression (LTD) in the rat visual cortex in vivo.

  Brain research 20100308

• Noradrenergic control of associative synaptic plasticity by selective modulation of instructive signals.

  Neuron 20090416

• Role of glutamate transporters in corticostriatal synaptic transmission.

  Neuroscience 20090218

• The role of different glutamate receptors in the mediation of glutamate-evoked excitation of red nucleus neurons after simulated microgravity in rat.

  Neuroscience letters 20081231

• GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses.

  Nature neuroscience 20081201

• Activation of group I metabotropic glutamate receptors induces long-term depression in the hippocampal CA1 region of adult rats in vitro.

  Neuroscience research 20080901

• An analysis of the stimulus requirements for setting the molecular switch reveals a lower threshold for metaplasticity than synaptic plasticity.

  Neuropharmacology 20080901

• The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs.

  Neuropharmacology 20080901

• Serum differentially modifies the transcription and translation of NMDAR subunits in retinal neurons.

  Neurochemical research 20080801

• N-acetyl-L-aspartate activates hippocampal CA3 neurons in rodent slice preparations.

  Brain research bulletin 20080328

• Role of spinal metabotropic glutamate receptors in regulation of lower urinary tract function in the decerebrate unanesthetized rat.

  Neuroscience letters 20070608

• Glutamate pretreatment affects Ca2+ signaling in processes of astrocyte pairs.

  Journal of neurochemistry 20070101

• Unique regulation of long term potentiation in the rat ventral hippocampus.

  Hippocampus 20070101

• Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses.

  Journal of neurophysiology 20061201

• Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats.

  Brain research bulletin 20061016

• Disinhibition of the cardiac limb of the arterial baroreflex in rat: a role for metabotropic glutamate receptors in the nucleus tractus solitarii.

  The Journal of physiology 20060915

• Activation of adenosine A2A receptors alters postsynaptic currents and depolarizes neurons of the supraoptic nucleus.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060801

• Chemoreflex sympathoexcitation was not altered by the antagonism of glutamate receptors in the commissural nucleus tractus solitarii in the working heart-brainstem preparation of rats.

  Experimental physiology 20060501

• Olfactory nerve stimulation-evoked mGluR1 slow potentials, oscillations, and calcium signaling in mouse olfactory bulb mitral cells.

  Journal of neurophysiology 20060501

• Sustained activation of metabotropic glutamate receptor 5 and protein tyrosine phosphatases mediate the expression of (S)-3,5-dihydroxyphenylglycine-induced long-term depression in the hippocampal CA1 region.

  Journal of neurochemistry 20060101

• Long-term modulation of electrical synapses in the mammalian thalamus.

  Science (New York, N.Y.) 20051216

• Metabotropic glutamate receptor agonists modify the pyloric output of the crustacean stomatogastric ganglion.

  Brain research 20051116

• Involvement of IP3 receptors in LTP and LTD induction in guinea pig hippocampal CA1 neurons.

  Learning & memory (Cold Spring Harbor, N.Y.) 20051101

• Dissection of bidirectional synaptic plasticity into saturable unidirectional processes.

  Journal of neurophysiology 20050801

• Anteroventral third ventricular N-methyl-D-aspartate receptors, but not metabotropic glutamate receptors are involved in hemorrhagic AVP secretion.

  Brain research bulletin 20050715

• Substrate-induced modulation of glutamate uptake in human platelets.

  British journal of pharmacology 20050701

• Propionic and methylmalonic acids increase cAMP levels in slices of cerebral cortex of young rats via adrenergic and glutamatergic mechanisms.

  Biochimica et biophysica acta 20050610

• Immunocytochemical and pharmacological characterization of metabotropic glutamate receptors of the vestibular end organs in the frog.

  Hearing research 20050601

• Stromal cell-derived factor-1alpha directly modulates voltage-dependent currents of the action potential in mammalian neuronal cells.

  Journal of neurochemistry 20050501

• Long-term depression at olfactory nerve synapses.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050427

• Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050302

• Local calcium transients regulate the spontaneous motility of dendritic filopodia.

  Nature neuroscience 20050301

• Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat.

  Brain research 20041119

• Bi-directional plasticity and age-dependent long-term depression at mouse CA3-CA1 hippocampal synapses.

  Neuroscience letters 20040826

• AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms.

  The European journal of neuroscience 20040501

• In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.

  Journal of neurochemistry 20040301

• NMDA receptor expression and roles in human articular chondrocyte mechanotransduction.

  Biorheology 20040101

• Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201

• Dynamics of Ca(2+) and Na(+) in the dendrites of mouse cerebellar Purkinje cells evoked by parallel fibre stimulation.

  The European journal of neuroscience 20031101

• Hydroxyl radicals release in rat striatum involves metabotropic glutamate receptors.

  Brain research bulletin 20030830

• Cooperativity between activation of metabotropic glutamate receptors and NMDA receptors in the induction of LTP in hippocampal CA1 neurons.

  Neuroscience research 20030801

• Synaptically activated Ca2+ waves in layer 2/3 and layer 5 rat neocortical pyramidal neurons.

  The Journal of physiology 20030601

• Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone inputs to LHC of carp retina.

  Brain research bulletin 20030415

• Role of L-glutamate in systemic AVP-induced hypothermia.

  Journal of applied physiology (Bethesda, Md. : 1985) 20030101

• Dual modulation of gabaergic transmission by metabotropic glutamate receptors in rat ventral tegmental area.

  Neuroscience 20030101