887936-68-7 | BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$25.00	$18.00
5mg	97%	in stock	$53.00	$37.00

Description

• Catalog Number: AI69052
• Chemical Name: BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-
• CAS Number: 887936-68-7
• Molecular Formula: C24H28N4O4
• Molecular Weight: 436.5035
• MDL Number: MFCD18206792
• SMILES: COc1cccc(c1)C(=O)Nc1ccc(c(c1)c1ccnn1C)OCCN1CCOCC1

Computed Properties

• Complexity: 588
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 8
• XLogP3: 2.3

Literature

• Serotonin antagonism improves platelet inhibition in clopidogrel low-responders after coronary stent placement: an in vitro pilot study.

  PloS one 20120101

• Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis.

  Journal of medicinal chemistry 20100610

• Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis.

  Journal of thrombosis and haemostasis : JTH 20100201

• APD791, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology.

  The Journal of pharmacology and experimental therapeutics 20091001