89796-99-6 | 2-[(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$16.00	$11.00
5g	98%	in stock	$25.00	$17.00
25g	98%	in stock	$33.00	$23.00
100g	98%	in stock	$75.00	$52.00
500g	98%	in stock	$314.00	$220.00

Description

• Catalog Number: AB70373
• Chemical Name: 2-[(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic acid
• CAS Number: 89796-99-6
• Molecular Formula: C16H13Cl2NO4
• Molecular Weight: 354.18471999999997
• MDL Number: MFCD00864296
• SMILES: OC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl

Computed Properties

• Complexity: 411
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 7
• XLogP3: 4.3

Literature

• Improved Pharmacokinetics of Aceclofenac Immediate Release Tablets Incorporating its Inclusion Complex with Hydroxypropyl-β-Cyclodextrin.

  Scientia pharmaceutica 20150101

• Topical delivery of aceclofenac: challenges and promises of novel drug delivery systems.

  BioMed research international 20140101

• Comparison of gastrointestinal safety and tolerability of aceclofenac with diclofenac: a multicenter, randomized, double-blind study in patients with knee osteoarthritis.

  Current medical research and opinion 20130701

• Electrospun zein/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole.

  International journal of pharmaceutics 20121115

• Development and validation of packed column supercritical fluid chromatographic technique for quantification of chlorzoxazone, paracetamol and aceclofenac in their individual and combined dosage forms.

  Journal of chromatographic science 20121001

• Preparation and in vitro in vivo evaluation of aceclofenac loaded alginate microspheres: an investigation of effects of polymer using multiple comparison analysis.

  Current drug delivery 20120901

• Formulation development and optimization of bilayer tablets of aceclofenac.

  Expert opinion on drug delivery 20120901

• Quantitative determination of aceclofenac and its three major metabolites in rat plasma by HPLC-MS/MS.

  Journal of separation science 20120901

• Effect of particle size on the dissolution behaviors of poorly water-soluble drugs.

  Archives of pharmacal research 20120701

• Prescription of and adherence to non-steroidal anti-inflammatory drugs and gastroprotective agents in at-risk gastrointestinal patients.

  The American journal of gastroenterology 20120501

• Flow Cytometry-Assisted Basophil Activation Test as a Safe Diagnostic Tool for Aspirin/NSAID Hypersenstivity.

  Allergy, asthma & immunology research 20120501

• Rheological studies on solid lipid nanoparticle based carbopol gels of aceclofenac.

  Colloids and surfaces. B, Biointerfaces 20120401

• Non-steroidal anti-inflammatory drugs and gastroprotection with proton pump inhibitors: a focus on ketoprofen/omeprazole.

  Clinical drug investigation 20120401

• Effect of aceclofenac on pharmacokinetic of phenytoin.

  Pakistan journal of pharmaceutical sciences 20120401

• Diffusion of counterfeit drugs in developing countries and stability of galenics stored for months under different conditions of temperature and relative humidity.

  Croatian medical journal 20120401

• Development and characterization of zein-based microcarrier system for sustained delivery of aceclofenac sodium.

  AAPS PharmSciTech 20120301

• Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.

  The Cochrane database of systematic reviews 20120215

• The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID).

  Clinical rheumatology 20120201

• Pharmacokinetics of a new once-daily controlled-release formulation of aceclofenac in Korean healthy subjects compared with immediate-release aceclofenac and the effect of food: a randomized, open-label, three-period, crossover, single-centre study.

  Clinical drug investigation 20120201

• Content uniformity in granules for aceclofenac controlled release (CR) tablets determined using near-infrared spectroscopy and wide area illumination (WAI) Raman spectroscopy.

  Archives of pharmacal research 20120201

• Psychiatric symptoms of patients with primary mitochondrial DNA disorders.

  Behavioral and brain functions : BBF 20120101

• Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study.

  PloS one 20120101

• Influence of the flexible liposomes on the skin deposition of a hydrophilic model drug, carboxyfluorescein: dependency on their composition.

  TheScientificWorldJournal 20120101

• Sensitive spectrophotometric determination of aceclofenac following azo dye formation with 4-carboxyl-2,6-dinitrobenzene diazonium ion.

  Acta poloniae pharmaceutica 20120101

• Efficacy and tolerability of fixed-dose combination of dexketoprofen and dicyclomine injection in acute renal colic.

  Pain research and treatment 20120101

• Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide.

  International journal of nanomedicine 20120101

• Application of HPLC for the simultaneous determination of aceclofenac, paracetamol and tramadol hydrochloride in pharmaceutical dosage form.

  Scientia pharmaceutica 20120101

• Nanostructured Lipid Carriers (NLC)-Based Gel for the Topical Delivery of Aceclofenac: Preparation, Characterization, and In Vivo Evaluation.

  Scientia pharmaceutica 20120101

• To evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain.

  Journal of the Indian Medical Association 20120101

• The efficacy of pre-operative oral medication of paracetamol, ibuprofen, and aceclofenac on the success of maxillary infiltration anesthesia in patients with irreversible pulpitis: A double-blind, randomized controlled clinical trial.

  Journal of conservative dentistry : JCD 20120101

• Drug-induced Sweet's syndrome by aceclofenac.

  Cutaneous and ocular toxicology 20111201

• Mixed micelle formation with hydrophobic and hydrophilic Pluronic block copolymers: implications for controlled and targeted drug delivery.

  Colloids and surfaces. B, Biointerfaces 20111201

• Annular leukocytoclastic vasculitis in a patient with ulcerative colitis.

  Annals of dermatology 20111201

• Aceclofenac delivery by microencapsulation using LBL self-assembly for delayed release.

  Pakistan journal of pharmaceutical sciences 20111001

• Multiple fibromas of tendon sheath: unusual presentation.

  Annals of dermatology 20110901

• Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol.

  Journal of Korean medical science 20110801

• Evaluation and modeling of the eutectic composition of various drug-polyethylene glycol solid dispersions.

  Pharmaceutical development and technology 20110601

• The impact of fentanyl matrix on pain and function in spinal disorder-related chronic pain: an open label trial in Korea.

  Asian spine journal 20110601

• Randomized double blind comparative study on the efficacy of Ibuprofen and aceclofenac in controlling post-operative sequelae after third molar surgery.

  Journal of maxillofacial and oral surgery 20110601

• Efficacy and safety of aceclofenac-cr and aceclofenac in the treatment of knee osteoarthritis: a 6-week, comparative, randomized, multicentric, double-blind study.

  The journal of pain : official journal of the American Pain Society 20110501

• Prescription pattern of NSAIDs and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients in clinical practice in Korea.

  Journal of Korean medical science 20110401

• ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis.

  Annals of the rheumatic diseases 20110201

• Glycerogelatin-based ocular inserts of aceclofenac: physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation.

  Drug delivery 20110101

• Screening of conditions controlling spectrophotometric sequential injection analysis.

  Chemistry Central journal 20110101

• Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study.

  Arthritis research & therapy 20110101

• Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

  BMC neurology 20110101

• Formulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres.

  International journal of nanomedicine 20110101

• [The efficiency of aceclofenac in acute vertebrogenic compression-ischemic syndrome].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis.

  Arthritis research & therapy 20110101

• Dissolution behavior of β-cyclodextrin molecular inclusion complexes of aceclofenac.

  Journal of pharmacy & bioallied sciences 20110101

• Spectrophotometric determination of tizanidine and orphenadrine via ion pair complex formation using eosin Y.

  Chemistry Central journal 20110101

• Stability indicating HPLC determination of risperidone in bulk drug and pharmaceutical formulations.

  International journal of analytical chemistry 20110101

• Gingival veneer: Mask the unesthetic.

  Journal of Indian Society of Periodontology 20110101

• Formulation and evaluation of aceclofenac mouth-dissolving tablet.

  Journal of advanced pharmaceutical technology & research 20110101

• Development and evaluation of aceclofenac-loaded mucoadhesive microcapsules.

  Journal of advanced pharmaceutical technology & research 20110101

• Solubility and dissolution enhancement of etoricoxib by solid dispersion technique using sugar carriers.

  ISRN pharmaceutics 20110101

• Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form.

  Indian journal of pharmaceutical sciences 20110101

• Preparation and gamma scintigraphic evaluation of colon specific pellets of ketoprofen prepared by powder layering technology.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

• Solubility of aceclofenac in polyamidoamine dendrimer solutions.

  International journal of pharmaceutical investigation 20110101

• Heterotopic ossifications after arthroscopic management of femoroacetabular impingement: the role of NSAID prophylaxis.

  Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20101201

• Aceclofenac topical dosage forms: in vitro and in vivo characterization.

  Acta pharmaceutica (Zagreb, Croatia) 20101201

• Pulsed radiofrequency lesioning for treatment of chronic breast neuropathic pain after breast reduction -A case report-.

  Korean journal of anesthesiology 20101201

• Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

  Healthcare informatics research 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats.

  Current drug delivery 20101001

• Formulation and evaluation of chitosan microspheres of aceclofenac for colon-targeted drug delivery.

  Biopharmaceutics & drug disposition 20101001

• Efficacy and safety of aceclofenac and drotaverine fixed-dose combination in the treatment of primary dysmenorrhoea: a double-blind, double-dummy, randomized comparative study with aceclofenac.

  European journal of obstetrics, gynecology, and reproductive biology 20100901

• Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis.

  Acta pharmaceutica (Zagreb, Croatia) 20100901

• Evaluation of the microstructure of semicrystalline solid dispersions.

  Molecular pharmaceutics 20100802

• Physicochemical principles of controlled release solid dispersion containing a poorly water-soluble drug.

  Therapeutic delivery 20100701

• Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding.

  Arthritis and rheumatism 20100601

• [Aceclofenac-induced acute cholestatic lesion].

  Gastroenterologia y hepatologia 20100501

• A review of the gastrointestinal safety data--a gastroenterologist's perspective.

  Rheumatology (Oxford, England) 20100501

• Hypertrophic cranial pachymeningitis induced by long-term administration of nonsteroidal antiinflammatory drugs.

  The Annals of pharmacotherapy 20100401

• Calcium alginate cross-linked polymeric microbeads for oral sustained drug delivery in arthritis.

  Drug discoveries & therapeutics 20100401

• Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting.

  Journal of Korean medical science 20100301

• Development and characterization of enteric-coated immediate-release pellets of aceclofenac by extrusion/spheronization technique using kappa-carrageenan as a pelletizing agent.

  AAPS PharmSciTech 20100301

• Design, synthesis, hydrolysis kinetics and phamacodynamic profiles of histidine and alanine conjugates of aceclofenac.

  Acta pharmaceutica (Zagreb, Croatia) 20100301

• Improvement of water solubility and in vitro dissolution rate of aceclofenac by complexation with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.

  Pharmaceutical development and technology 20100101

• Formulation and evaluation of floating, pulsatile, multiparticulates using pH-dependent swellable polymers.

  Pharmaceutical development and technology 20100101

• In vitro dissolution profile comparison of an anti-migraine combinational drug in dosage form.

  Se pu = Chinese journal of chromatography 20100101

• Sulfonamides of 2-[(2,6-dichlorophenyl)amino]phenyl acetoxyacetic acid and their antibacterial studies.

  Acta poloniae pharmaceutica 20100101

• Role of amino acid infusion in delayed recovery from neuromuscular blockers.

  Indian journal of anaesthesia 20100101

• Chitosan microspheres of aceclofenac: in vitro and in vivo evaluation.

  Pharmaceutical development and technology 20100101

• Fabrication and Evaluation of Bi-layer Tablet Containing Conventional Paracetamol and Modified Release Diclofenac Sodium.

  Indian journal of pharmaceutical sciences 20100101

• New spectrophotometric estimation of ornidazole tablets employing urea as a hydrotropic solubilizing additive.

  Indian journal of pharmaceutical sciences 20100101

• Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream.

  International journal of nanomedicine 20100101

• Microencapsulation: an acclaimed novel drug-delivery system for NSAIDs in arthritis.

  Critical reviews in therapeutic drug carrier systems 20100101

• Preparation and in vivo evaluation of indomethacin loaded true nanoemulsions.

  Scientia pharmaceutica 20100101

• Visible spectrophotometric estimation of diacerein in bulk and pharmaceutical dosage forms.

  Journal of young pharmacists : JYP 20100101

• Assessment of dissolution profile of marketed aceclofenac formulations.

  Journal of young pharmacists : JYP 20100101

• Development and evaluation of pharmacosomes of aceclofenac.

  Indian journal of pharmaceutical sciences 20100101

• Preparation and Characterization of Ethosomes for Topical delivery of Aceclofenac.

  Indian journal of pharmaceutical sciences 20100101

• Novel application of hydrotropic solubilizing additives in the estimation of aspirin in tablets.

  Indian journal of pharmaceutical sciences 20100101

• Risk of Upper Gastrointestinal Bleeding in a Cohort of New Users of Low-Dose ASA for Secondary Prevention of Cardiovascular Outcomes.

  Frontiers in pharmacology 20100101

• Ridge augmentation and root coverage using acellular dermal matrix: a case report.

  Dental research journal 20100101

• A novel method for quantitative determination of aceclofenac in bulk drug and tablets using sodium salicylate as a hydrotropic solubilizing agent.

  Journal of advanced pharmaceutical technology & research 20100101

• Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone.

  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20091201

• A case of tuberculous arthritis following the use of etanercept.

  The Korean journal of internal medicine 20091201

• Almotriptan efficacy in migraine with allodynia: a critique of Schoenen et al.

  Cephalalgia : an international journal of headache 20091001

• Preparation and characterization of spray-dried mucoadhesive microspheres of aceclofenac.

  Drug development and industrial pharmacy 20091001

• Photoallergic contact dermatitis due to diclofenac with cross-reaction to aceclofenac: two case reports.

  Contact dermatitis 20091001

• Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care.

  Methods and findings in experimental and clinical pharmacology 20091001

• Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations.

  Acta pharmaceutica (Zagreb, Croatia) 20090901

• Preparation and characterization of co-grinded mixtures of aceclofenac and neusilin US2 for dissolution enhancement of aceclofenac.

  AAPS PharmSciTech 20090601

• Dissolution-modulating mechanism of alkalizers and polymers in a nanoemulsifying solid dispersion containing ionizable and poorly water-soluble drug.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090501

• Simultaneous HPLC-UV determination of rhein and aceclofenac in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415

• A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up.

  Expert opinion on pharmacotherapy 20090401

• Product development studies of amino acid conjugate of Aceclofenac.

  Current drug delivery 20090401

• Multiparticulate drug delivery system of aceclofenac: development and in vitro studies.

  Drug development and industrial pharmacy 20090201

• Trace analysis of polar pharmaceuticals in wastewater by LC-MS-MS: comparison of membrane bioreactor and activated sludge systems.

  Journal of chromatographic science 20090101

• Development and evaluation of a time-specific pulsatile-release tablet of aceclofenac: a solution for morning pain in rheumatoid arthritis.

  Methods and findings in experimental and clinical pharmacology 20090101

• Aceclofenac organogels: in vitro and in vivo characterization.

  Current drug delivery 20090101

• Single dose oral aceclofenac for postoperative pain in adults.

  The Cochrane database of systematic reviews 20090101

• [Consumption of oral analgesics and dosage forms in elderly patients: population-based study].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101

• Stability indicating HPLC method for simultaneous determination of mephenesin and diclofenac diethylamine.

  Indian journal of pharmaceutical sciences 20090101

• Topical delivery of flurbiprofen from pluronic lecithin organogel.

  Indian journal of pharmaceutical sciences 20090101

• The effects of aceclofenac and nabumetone in osteoarthritis.

  JNMA; journal of the Nepal Medical Association 20090101

• Quantitative estimation of naproxen in tablets using Ibuprofen sodium as hydrotropic agent.

  Indian journal of pharmaceutical sciences 20090101

• Co-crystals: a novel approach to modify physicochemical properties of active pharmaceutical ingredients.

  Indian journal of pharmaceutical sciences 20090101

• Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis.

  Osteoarthritis and cartilage 20081201

• Current migraine management - patient acceptability and future approaches.

  Neuropsychiatric disease and treatment 20081201

• First evidence for occurrence of hydroxylated human metabolites of diclofenac and aceclofenac in wastewater using QqLIT-MS and QqTOF-MS.

  Analytical chemistry 20081101

• Preparation and, in vitro, preclinical and clinical studies of aceclofenac spherical agglomerates.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081001

• Vesicular aceclofenac systems: a comparative study between liposomes and niosomes.

  Journal of microencapsulation 20081001

• Almotriptan and its combination with aceclofenac for migraine attacks: a study of efficacy and the influence of auto-evaluated brush allodynia.

  Cephalalgia : an international journal of headache 20081001

• Clinical pharmacology.

  Indian journal of pharmacology 20081001

• Chondroprotective Potential of Fruit Extracts of Phyllanthus emblica in Osteoarthritis.

  Evidence-based complementary and alternative medicine : eCAM 20080901

• Simultaneous determination of aceclofenac, paracetamol, and chlorzoxazone by RP-HPLC in pharmaceutical dosage form.

  Journal of chromatographic science 20080801

• Skin permeation mechanism of aceclofenac using novel nanoemulsion formulation.

  Die Pharmazie 20080801

• Evaluation of SLS: APG mixed surfactant systems as carrier for solid dispersion.

  AAPS PharmSciTech 20080601

• Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: in vitro and in vivo studies.

  AAPS PharmSciTech 20080601

• PARFLEX--a very useful drug for management of surgical pain.

  Journal of the Indian Medical Association 20080601

• Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene.

  International journal of cancer 20080415

• Prescribing pattern of drugs in the treatment of osteoarthritis in Italian general practice: the effect of rofecoxib withdrawal.

  Arthritis and rheumatism 20080415

• Bioequivalence and pharmacokinetic evaluation of two branded formulations of aceclofenac 100 mg: a single-dose, randomized, open-label, two-period crossover comparison in healthy Korean adult volunteers.

  Clinical therapeutics 20080401

• Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs.

  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20080301

• Lipospheres as carriers for topical delivery of aceclofenac: preparation, characterization and in vivo evaluation.

  AAPS PharmSciTech 20080301

• Enhancement of dissolution rate and bioavailability of aceclofenac: a chitosan-based solvent change approach.

  International journal of pharmaceutics 20080227

• Two cases of acute leukopenia induced by colchicine with concurrent immunosuppressants use in Behçet's disease.

  Yonsei medical journal 20080227

• Simultaneous determination of aceclofenac and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20080213

• Mathematical evaluation of similarity factor using various weighing approaches on aceclofenac marketed formulations by model-independent method.

  Die Pharmazie 20080101

• A simple and sensitive stability-indicating RP-HPLC assay method for the determination of aceclofenac.

  Journal of chromatographic science 20080101

• Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion.

  Journal of nanobiotechnology 20080101

• Development of fast dispersible aceclofenac tablets: effect of functionality of superdisintegrants.

  Indian journal of pharmaceutical sciences 20080101

• Formulation Development and in vitro Characterization of Proliposomes for Topical Delivery of Aceclofenac.

  Indian journal of pharmaceutical sciences 20080101

• Formulation and evaluation of gelatin micropellets of aceclofenac: effect of process variables on encapsulation efficiency, particle size and drug release.

  Indian journal of pharmaceutical sciences 20080101

• Analysis of bulk sample of salicylic Acid by application of hydrotropic solubilization method.

  Indian journal of pharmaceutical sciences 20080101

• Estimation of paracetamol and aceclofenac in tablet formulation by ratio spectra derivative spectroscopy.

  Indian journal of pharmaceutical sciences 20080101

• Aceclofenac vs paracetamol in the management of symptomatic osteoarthritis of the knee: a double-blind 6-week randomized controlled trial.

  Osteoarthritis and cartilage 20070801

• [After taking non-steroidal anti-inflammatory agents. What is the cause of the 'blue spot?' ].

  MMW Fortschritte der Medizin 20070719

• Improved bioavailability of aceclofenac from spherical agglomerates: development, in vitro and preclinical studies.

  Pakistan journal of pharmaceutical sciences 20070701

• Nanoemulsions as vehicles for transdermal delivery of aceclofenac.

  AAPS PharmSciTech 20070601

• Incidence of spontaneous notifications of adverse reactions with aceclofenac, meloxicam, and rofecoxib during the first year after marketing in the United Kingdom.

  Therapeutics and clinical risk management 20070601

• Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.

  Chemico-biological interactions 20070520

• Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry--do they comply with FDA recommendations?

  Chemico-biological interactions 20070520

• In vitro effects of non-steroidal anti-inflammatory drugs on cytokine, prostanoid and matrix metalloproteinase production by interface membranes from loose hip or knee endoprostheses.

  Osteoarthritis and cartilage 20070501

• Fixed drug eruption due to aceclofenac.

  Contact dermatitis 20070501

• Traditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: a drug-drug interaction?

  PLoS medicine 20070501

• Photodegradation and in vitro phototoxicity of aceclofenac.

  Die Pharmazie 20070501

• Influence of amorphous cyclodextrin derivatives on aceclofenac release from directly compressible tablets.

  Die Pharmazie 20070401

• Comparison of Prevention of NSAID-Induced Gastrointestinal Complications by Rebamipide and Misoprostol: A Randomized, Multicenter, Controlled Trial-STORM STUDY.

  Journal of clinical biochemistry and nutrition 20070301

• High-performance liquid chromatography and pharmacokinetics of aceclofenac in rats.

  Analytica chimica acta 20070227

• Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac.

  Archives of pharmacal research 20070201

• Immunomodulatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) at the clinically available doses.

  Archives of pharmacal research 20070101

• The efficacy and safety of aceclofenac versus placebo and naproxen in women with primary dysmenorrhoea.

  European journal of obstetrics, gynecology, and reproductive biology 20061201

• Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations.

  Gut 20061201

• Allergic contact dermatitis due to aceclofenac.

  Contact dermatitis 20061201

• Consumption costs of inappropriate medicines estimated from bulk purchase data: The example of NSAids in Guatemala.

  International journal of clinical pharmacology and therapeutics 20061101

• Topical delivery of aceclofenac from lecithin organogels: preformulation study.

  Current drug delivery 20061001

• Generalized pustular psoriasis precipitated by aceclofenac.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20060901

• [A case of complete regression of hepatocellular carcinoma during administration of COX-2 inhibitor].

  The Korean journal of hepatology 20060901

• Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac.

  Annals of the rheumatic diseases 20060801

• Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems.

  Fundamental & clinical pharmacology 20060801

• Analgesic efficacy of aceclofenac after surgical extraction of impacted lower third molars.

  International journal of oral and maxillofacial surgery 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Efficacy and safety of aceclofenac in the treatment of osteoarthritis: a randomized double-blind comparative clinical trial versus diclofenac - an Indian experience.

  Current medical research and opinion 20060501

• Anaphylactic reaction after aceclofenac intake.

  Allergy 20060401

• Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study.

  Arthritis research & therapy 20060101

• Effect of processing variables on micro particulate system of aceclofenac.

  Pakistan journal of pharmaceutical sciences 20060101

• [Clinical pharmacogenomics for CYP2C8 and CYP2C9: general concepts and application to the use of NSAIDs].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20060101

• Evaluation of bioequivalence of two formulations containing 100 milligrams of aceclofenac.

  Drug development and industrial pharmacy 20060101

• Physicochemical characterization and dissolution enhancement of aceclofenac-hydroxypropyl beta-cyclodextrin binary systems.

  PDA journal of pharmaceutical science and technology 20060101

• Trials of clear aceclofenac-loaded soft capsules with accelerated oral absorption in human subjects.

  International journal of pharmaceutics 20050930

• Formulation of microemulsion systems for transdermal delivery of aceclofenac.

  Archives of pharmacal research 20050901

• Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.

  Biochemical pharmacology 20050701

• Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes.

  Archives of dermatology 20050701

• Separation of aceclofenac and diclofenac in human plasma by free zone capillary electrophoresis using N-methyl-D-glucamine as an effective electrolyte additive.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050301

• [Aceclofenac (aertal) in rheumatological practice].

  Terapevticheskii arkhiv 20050101

• Manipulative therapy and/or NSAIDs for acute low back pain: design of a randomized controlled trial [ACTRN012605000036617].

  BMC musculoskeletal disorders 20050101

• Long-term use of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction in the general population.

  BMC medicine 20050101

• Stability of response characteristics of a Delphi panel: application of bootstrap data expansion.

  BMC medical research methodology 20050101

• Comparative efficacy of aceclofenac and etoricoxib in post extraction pain control: randomized control trial.

  Indian journal of dental research : official publication of Indian Society for Dental Research 20050101

• Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene.

  Biochemical and biophysical research communications 20041224

• [Function of non-steroids in dentistry and oral surgery. A favourable experiences with aceclofenac].

  Fogorvosi szemle 20041201

• Polarographic behaviour of Aceclofenac, Tenoxicam and Droxicam in a methanol-water mixture.

  Journal of pharmaceutical and biomedical analysis 20040921

• Pain and osteoarthritis: new drugs and mechanisms.

  Current opinion in rheumatology 20040901

• Risk of breast cancer among users of aspirin and other anti-inflammatory drugs.

  British journal of cancer 20040802

• Aceclofenac in the management of inflammatory pain.

  Expert opinion on pharmacotherapy 20040601

• Drug metabolism by cultured human hepatocytes: how far are we from the in vivo reality?

  Alternatives to laboratory animals : ATLA 20040601

• [Determination of aceclofenac in human plasma by reversed-phase high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20040501

• Bioequivalence evaluation of two brands of aceclofenac 100 mg tablets (Aceclofar and Bristaflam) in healthy human volunteers.

  Biopharmaceutics & drug disposition 20040401

• Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents.

  Drug safety 20040101

• Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac.

  Clinical pharmacology and therapeutics 20030901

• [Intramuscular aceclofenac and necrosis at the point of injection with fatal outcome].

  Atencion primaria 20030630

• Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20030601

• A double-blind, multicentre, randomised clinical trial comparing the efficacy and tolerability of aceclofenac with diclofenac resinate in patients with acute low back pain.

  Clinical rheumatology 20030501

• [Exudative erythema multiforme with transition to a toxic epidermal necrolysis after taking aceclofenac (Beofenac)].

  Deutsche medizinische Wochenschrift (1946) 20030307

• Stability indicating methods for the determination of aceclofenac.

  Farmaco (Societa chimica italiana : 1989) 20030201

• Management pattern for patients with osteoarthritis treated with traditional non-steroidal anti-inflammatory drugs in Spain prior to introduction of Coxibs.

  Current medical research and opinion 20030101

• [Acid coxibs, NO donors, cytokine inhibitors. New beginnings against rheumatism].

  MMW Fortschritte der Medizin 20021128

• Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs.

  The Journal of biological chemistry 20021011

• Preparation and evaluation of aceclofenac microemulsion for transdermal delivery system.

  Archives of pharmacal research 20020801

• Dose-effect relationships of nonsteroidal anti-inflammatory drugs: a literature review.

  Clinical therapeutics 20020801

• Regulation by reactive oxygen species of interleukin-1beta, nitric oxide and prostaglandin E(2) production by human chondrocytes.

  Osteoarthritis and cartilage 20020701

• Do NSAIDs affect the progression of osteoarthritis?

  Inflammation 20020601

• Stability-indicating spectrophotometric and densitometric methods for determination of aceclofenac.

  Drug development and industrial pharmacy 20020501

• Metabolism of human articular chondrocytes cultured in alginate beads. Longterm effects of interleukin 1beta and nonsteroidal antiinflammatory drugs.

  The Journal of rheumatology 20020401

• Determination of aceclofenac in bulk and pharmaceutical formulations.

  Journal of pharmaceutical and biomedical analysis 20020101

• Comparative incidence of upper gastrointestinal bleeding associated with individual non-steroidal anti-inflammatory drugs.

  Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20020101

• Patient and physician satisfaction with aceclofenac: results of the European Observational Cohort Study (experience with aceclofenac for inflammatory pain in daily practice). Aceclofenac is the treatment of choice for patients and physicians in the management of inflammatory pain.

  Current medical research and opinion 20020101

• Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.

  The Journal of rheumatology 20011201

• [Toxic hepatitis caused by aceclofenac].

  Revista clinica espanola 20011001

• Photoallergic contact dermatitis from aceclofenac.

  Contact dermatitis 20010901

• In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010801

• [What is the role of aceclofenac in the therapeutic arsenal against chronic osteoarthritis pathologies?].

  Revue medicale de Liege 20010701

• Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro.

  Journal of hand surgery (Edinburgh, Scotland) 20010601

• In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs).

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010501

• Bioequivalence of two aceclofenac tablet formulations after a single oral dose to healthy male Korean volunteers.

  International journal of clinical pharmacology and therapeutics 20010201

• Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor.

  Journal of hepatology 20010101

• Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations.

  BMC clinical pharmacology 20010101

• Aceclofenac: a reappraisal of its use in the management of pain and rheumatic disease.

  Drugs 20010101

• Iatrogenic cost factors incorporating mild and moderate adverse events in the economic comparison of aceclofenac and other NSAIDs.

  PharmacoEconomics 20010101

• Hypersensitivity vasculitis related to aceclofenac.

  British journal of rheumatology 19970401

• Aceclofenac. A review of its pharmacodynamic properties and therapeutic potential in the treatment of rheumatic disorders and in pain management.

  Drugs 19960701

• Aceclofenac, a new nonsteroidal antiinflammatory drug, decreases the expression and function of some adhesion molecules on human neutrophils.

  The Journal of rheumatology 19960401

• The efficacy and tolerability of aceclofenac compared to indomethacin in patients with rheumatoid arthritis.

  Rheumatology international 19960101

• Leukocytoclastic vasculitis and hemoptysis after treatment with aceclofenac.

  The Annals of pharmacotherapy 19951101

• [NSAID-induced hepatotoxicity: aceclofenac and diclofenac].

  Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 19950601

• [Aceclofenac and mental confusion].

  Atencion primaria 19940415

• [Vasculitis from hypersensitivity and aceclofenac].

  Medicina clinica 19930703